locus-tag	class	description
ABCA12_0002	COG0592	DNA-directed DNA polymerase activity
ABCA12_0004	COG0187	DNA topoisomerase II activity
ABCA12_0006	COG0586	Pfam SNARE associated Golgi protein
ABCA12_0007	COG0488	(ABC) transporter
ABCA12_0015	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ABCA12_0016	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ABCA12_0022	COG0733	neurotransmitter:sodium symporter activity
ABCA12_0029	COG2233	PERMEase
ABCA12_0031	COG1309	transcriptional regulator
ABCA12_0032	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ABCA12_0038	COG2814	Major facilitator Superfamily
ABCA12_0039	COG0656	L-ascorbic acid biosynthetic process
ABCA12_0040	COG0583	DNA-binding transcription factor activity
ABCA12_0042	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ABCA12_0043	COG1064	alcohol dehydrogenase
ABCA12_0044	COG2818	Glycosylase
ABCA12_0046	COG0739	heme binding
ABCA12_0049	COG5487	UPF0391 membrane protein
ABCA12_0050	COG2983	Belongs to the UPF0260 family
ABCA12_0051	COG2133	pyrroloquinoline quinone binding
ABCA12_0053	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ABCA12_0057	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ABCA12_0059	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ABCA12_0060	COG1335	isochorismatase
ABCA12_0063	COG4372	Transposase
ABCA12_0079	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ABCA12_0081	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ABCA12_0082	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ABCA12_0083	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ABCA12_0087	COG3830	Belongs to the UPF0237 family
ABCA12_0087	COG0560	Phosphoserine phosphatase
ABCA12_0096	COG0583	DNA-binding transcription factor activity
ABCA12_0103	COG0534	Mate efflux family protein
ABCA12_0104	COG0436	Aminotransferase
ABCA12_0106	COG2733	membrane
ABCA12_0109	COG2918	glutathione biosynthetic process
ABCA12_0112	COG1388	LysM domain
ABCA12_0112	COG1705	Flagellar rod assembly protein muramidase FlgJ
ABCA12_0118	COG3150	esterase
ABCA12_0121	COG0534	Mate efflux family protein
ABCA12_0129	COG1247	-acetyltransferase
ABCA12_0140	COG0708	Exodeoxyribonuclease III
ABCA12_0152	COG1846	Transcriptional regulator
ABCA12_0153	COG0386	Belongs to the glutathione peroxidase family
ABCA12_0154	COG0189	ligase activity
ABCA12_0158	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ABCA12_0160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ABCA12_0167	COG2119	membrane
ABCA12_0168	COG4774	siderophore transport
ABCA12_0169	COG0426	domain, Protein
ABCA12_0169	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ABCA12_0173	COG0259	pyridoxamine-phosphate oxidase activity
ABCA12_0174	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ABCA12_0179	COG1902	pentaerythritol trinitrate reductase activity
ABCA12_0180	COG1519	Transferase
ABCA12_0181	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ABCA12_0182	COG0668	transmembrane transport
ABCA12_0184	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ABCA12_0185	COG1335	isochorismatase
ABCA12_0194	COG1309	transcriptional regulator
ABCA12_0195	COG1028	Short-chain dehydrogenase reductase Sdr
ABCA12_0195	COG3321	synthase
ABCA12_0195	COG0604	alcohol dehydrogenase
ABCA12_0197	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ABCA12_0199	COG2814	Major facilitator Superfamily
ABCA12_0200	COG0629	single-stranded DNA binding
ABCA12_0201	COG1113	amino acid transport
ABCA12_0203	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ABCA12_0204	COG1012	belongs to the aldehyde dehydrogenase family
ABCA12_0206	COG1335	isochorismatase
ABCA12_0208	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ABCA12_0213	COG3293	Transposase
ABCA12_0242	COG0305	Participates in initiation and elongation during chromosome replication
ABCA12_0250	COG0582	viral genome integration into host DNA
ABCA12_0258	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ABCA12_0262	COG2329	Antibiotic biosynthesis monooxygenase
ABCA12_0264	COG1396	sequence-specific DNA binding
ABCA12_0265	COG0659	secondary active sulfate transmembrane transporter activity
ABCA12_0269	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ABCA12_0273	COG0427	acetyl-CoA hydrolase
ABCA12_0283	COG0477	Major facilitator Superfamily
ABCA12_0284	COG0789	Transcriptional regulator
ABCA12_0285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ABCA12_0285	COG3320	Male sterility
ABCA12_0286	COG4221	oxidoreductase activity
ABCA12_0288	COG0488	(ABC) transporter
ABCA12_0303	COG0833	amino acid
ABCA12_0306	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ABCA12_0307	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ABCA12_0311	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ABCA12_0312	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ABCA12_0315	COG2226	methyltransferase
ABCA12_0325	COG0070	glutamate synthase
ABCA12_0325	COG0069	glutamate synthase activity
ABCA12_0325	COG0067	glutamate synthase
ABCA12_0326	COG0493	'glutamate synthase
ABCA12_0327	COG4372	Transposase
ABCA12_0330	COG1704	LemA family
ABCA12_0331	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ABCA12_0342	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ABCA12_0344	COG0194	GDP metabolic process
ABCA12_0345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ABCA12_0350	COG4969	Belongs to the N-Me-Phe pilin family
ABCA12_0360	COG4372	Transposase
ABCA12_0362	COG0228	four-way junction DNA binding
ABCA12_0363	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ABCA12_0365	COG0335	large ribosomal subunit rRNA binding
ABCA12_0366	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ABCA12_0367	COG5380	lipid catabolic process
ABCA12_0368	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ABCA12_0372	COG5006	permease, DMT superfamily
ABCA12_0373	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ABCA12_0374	COG0277	FAD linked oxidase domain protein
ABCA12_0378	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ABCA12_0379	COG2249	NAD(P)H dehydrogenase (quinone) activity
ABCA12_0383	COG1289	transmembrane transporter activity
ABCA12_0384	COG2032	superoxide dismutase activity
ABCA12_0385	COG0628	permease
ABCA12_0386	COG1192	Involved in chromosome partitioning
ABCA12_0388	COG2226	methyltransferase
ABCA12_0391	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ABCA12_0407	COG0471	metal ion transport
ABCA12_0409	COG0617	tRNA 3'-terminal CCA addition
ABCA12_0409	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ABCA12_0409	COG0517	IMP dehydrogenase activity
ABCA12_0410	COG1983	PspC domain protein
ABCA12_0412	COG1960	acyl-CoA dehydrogenase activity
ABCA12_0415	COG0408	coproporphyrinogen oxidase activity
ABCA12_0419	COG0513	Belongs to the DEAD box helicase family
ABCA12_0421	COG3293	Transposase
ABCA12_0422	COG1127	ABC transporter
ABCA12_0423	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ABCA12_0424	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ABCA12_0425	COG2854	intermembrane phospholipid transfer
ABCA12_0428	COG0598	Magnesium transport protein CorA
ABCA12_0431	COG1040	competence protein
ABCA12_0432	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ABCA12_0435	COG2937	Belongs to the GPAT DAPAT family
ABCA12_0436	COG1946	Acyl-CoA thioesterase
ABCA12_0437	COG1301	dicarboxylic acid transport
ABCA12_0440	COG1959	2 iron, 2 sulfur cluster binding
ABCA12_0442	COG0433	COG0433 Predicted ATPase
ABCA12_0446	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ABCA12_0450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ABCA12_0455	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ABCA12_0460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ABCA12_0463	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ABCA12_0476	COG1960	acyl-CoA dehydrogenase activity
ABCA12_0477	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ABCA12_0487	COG0697	spore germination
ABCA12_0490	COG0339	signal peptide processing
ABCA12_0492	COG0557	exoribonuclease II activity
ABCA12_0501	COG1295	ribonuclease BN
ABCA12_0509	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ABCA12_0515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ABCA12_0515	COG2813	Specifically methylates the guanine in position
ABCA12_0517	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ABCA12_0519	COG4774	siderophore transport
ABCA12_0521	COG0740	serine-type endopeptidase activity
ABCA12_0525	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ABCA12_0525	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ABCA12_0528	COG0857	belongs to the CobB CobQ family
ABCA12_0528	COG0280	phosphate acetyltransferase
ABCA12_0529	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ABCA12_0531	COG2267	carboxylic ester hydrolase activity
ABCA12_0534	COG0793	Belongs to the peptidase S41A family
ABCA12_0539	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ABCA12_0542	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ABCA12_0543	COG1408	metallophosphoesterase
ABCA12_0545	COG2199	diguanylate cyclase activity
ABCA12_0552	COG1607	acyl-coa hydrolase
ABCA12_0558	COG1666	GTP binding
ABCA12_0562	COG2350	Protein conserved in bacteria
ABCA12_0564	COG0613	PHP domain protein
ABCA12_0565	COG3781	membrane
ABCA12_0566	COG2003	Belongs to the UPF0758 family
ABCA12_0567	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ABCA12_0574	COG1162	GTPase activity
ABCA12_0575	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ABCA12_0580	COG1538	Outer membrane efflux protein
ABCA12_0581	COG0577	efflux transmembrane transporter activity
ABCA12_0581	COG1136	(ABC) transporter
ABCA12_0582	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ABCA12_0584	COG1466	dna polymerase III delta subunit
ABCA12_0588	COG0028	Belongs to the TPP enzyme family
ABCA12_0589	COG0440	acetolactate synthase activity
ABCA12_0590	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ABCA12_0595	COG0640	Transcriptional regulator
ABCA12_0597	COG0798	PFAM Bile acid sodium symporter
ABCA12_0598	COG0431	NADPH-dependent FMN reductase
ABCA12_0601	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ABCA12_0603	COG0726	polysaccharide deacetylase
ABCA12_0604	COG0084	hydrolase, TatD family'
ABCA12_0607	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ABCA12_0609	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ABCA12_0622	COG3152	Membrane
ABCA12_0633	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ABCA12_0638	COG2814	Major facilitator Superfamily
ABCA12_0645	COG0300	oxidoreductase activity
ABCA12_0646	COG0004	ammonium transporteR
ABCA12_0649	COG3622	Belongs to the hyi family
ABCA12_0650	COG2084	Dehydrogenase
ABCA12_0651	COG1024	Enoyl-CoA hydratase
ABCA12_0652	COG5002	protein histidine kinase activity
ABCA12_0652	COG0784	Response regulator, receiver
ABCA12_0652	COG2205	protein histidine kinase activity
ABCA12_0656	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ABCA12_0658	COG3956	TIGRFAM MazG family protein
ABCA12_0659	COG1555	photosystem II stabilization
ABCA12_0660	COG0617	tRNA 3'-terminal CCA addition
ABCA12_0661	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ABCA12_0666	COG3028	Belongs to the UPF0307 family
ABCA12_0667	COG0318	PFAM AMP-dependent synthetase and ligase
ABCA12_0671	COG0625	glutathione transferase activity
ABCA12_0673	COG1238	metal cluster binding
ABCA12_0680	COG0072	phenylalanine-tRNA ligase activity
ABCA12_0685	COG0248	Ppx GppA phosphatase
ABCA12_0687	COG0037	tRNA processing
ABCA12_0690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ABCA12_0690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ABCA12_0695	COG1764	response to oxidative stress
ABCA12_0697	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ABCA12_0704	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ABCA12_0705	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ABCA12_0706	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ABCA12_0716	COG0494	nUDIX hydrolase
ABCA12_0719	COG1968	undecaprenyl-diphosphatase activity
ABCA12_0724	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ABCA12_0726	COG2132	Multicopper oxidase
ABCA12_0732	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ABCA12_0733	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ABCA12_0739	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ABCA12_0740	COG1063	alcohol dehydrogenase
ABCA12_0744	COG1309	transcriptional regulator
ABCA12_0745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ABCA12_0748	COG2814	Major facilitator Superfamily
ABCA12_0762	COG0484	heat shock protein binding
ABCA12_0763	COG2801	Transposase and inactivated derivatives
ABCA12_0770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ABCA12_0773	COG0745	RESPONSE REGULATOR receiver
ABCA12_0774	COG2205	protein histidine kinase activity
ABCA12_0776	COG3706	GGDEF domain
ABCA12_0777	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ABCA12_0779	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ABCA12_0779	COG0649	NAD binding
ABCA12_0781	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ABCA12_0784	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ABCA12_0787	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ABCA12_0788	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ABCA12_0792	COG4372	Transposase
ABCA12_0795	COG1278	Cold shock
ABCA12_0796	COG0583	DNA-binding transcription factor activity
ABCA12_0797	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ABCA12_0800	COG0668	transmembrane transport
ABCA12_0802	COG2081	HI0933 family
ABCA12_0804	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ABCA12_0810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ABCA12_0812	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ABCA12_0812	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ABCA12_0817	COG0489	protein tyrosine kinase activity
ABCA12_0827	COG4636	protein conserved in cyanobacteria
ABCA12_0830	COG4372	Transposase
ABCA12_0831	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ABCA12_0833	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ABCA12_0838	COG0730	response to heat
ABCA12_0840	COG1196	nuclear chromosome segregation
ABCA12_0842	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ABCA12_0846	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ABCA12_0847	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ABCA12_0847	COG2226	methyltransferase
ABCA12_0847	COG0596	Alpha beta hydrolase
ABCA12_0850	COG4106	trans-aconitate 2-methyltransferase activity
ABCA12_0864	COG0601	transmembrane transport
ABCA12_0869	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ABCA12_0870	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ABCA12_0872	COG0009	L-threonylcarbamoyladenylate synthase
ABCA12_0873	COG3101	peptidyl-lysine hydroxylation
ABCA12_0874	COG1399	metal-binding, possibly nucleic acid-binding protein
ABCA12_0875	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ABCA12_0879	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ABCA12_0880	COG1652	LysM domain
ABCA12_0881	COG0352	thiamine-phosphate diphosphorylase activity
ABCA12_0881	COG0351	phosphomethylpyrimidine kinase
ABCA12_0881	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ABCA12_0883	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ABCA12_0892	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ABCA12_0894	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ABCA12_0899	COG0564	pseudouridine synthase activity
ABCA12_0905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ABCA12_0905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ABCA12_0912	COG1981	membrane
ABCA12_0916	COG0049	tRNA binding
ABCA12_0918	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ABCA12_0921	COG0456	acetyltransferase
ABCA12_0923	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ABCA12_0924	COG0500	methyltransferase
ABCA12_0925	COG0492	ferredoxin-NADP+ reductase activity
ABCA12_0926	COG1674	ftsk spoiiie
ABCA12_0927	COG1280	lysine exporter protein (LysE YggA)
ABCA12_0929	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ABCA12_0931	COG0850	regulation of cytokinetic process
ABCA12_0933	COG0204	Acyl-transferase
ABCA12_0934	COG2885	chlorophyll binding
ABCA12_0935	COG0210	DNA helicase
ABCA12_0936	COG0756	dUTP diphosphatase activity
ABCA12_0937	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ABCA12_0940	COG0121	glutamine amidotransferase
ABCA12_0944	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ABCA12_0950	COG0420	3'-5' exonuclease activity
ABCA12_0962	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ABCA12_0965	COG1566	PFAM secretion protein HlyD family protein
ABCA12_0966	COG2814	Major facilitator Superfamily
ABCA12_0968	COG0789	Transcriptional regulator
ABCA12_0969	COG2217	Heavy metal translocating P-type atpase
ABCA12_0970	COG0629	single-stranded DNA binding
ABCA12_0978	COG0582	viral genome integration into host DNA
ABCA12_0984	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ABCA12_0985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ABCA12_0987	COG1012	belongs to the aldehyde dehydrogenase family
ABCA12_0991	COG0833	amino acid
ABCA12_0994	COG4372	Transposase
ABCA12_0995	COG3040	lipid binding
ABCA12_0996	COG3046	protein related to deoxyribodipyrimidine photolyase
ABCA12_0997	COG0725	ABC transporter, periplasmic molybdate-binding protein
ABCA12_0998	COG4149	molybdate abc transporter
ABCA12_1001	COG1230	cation diffusion facilitator family transporter
ABCA12_1003	COG4521	taurine ABC transporter
ABCA12_1004	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ABCA12_1005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ABCA12_1006	COG2175	clavaminate synthase activity
ABCA12_1007	COG0589	response to stress
ABCA12_1011	COG0242	peptide deformylase activity
ABCA12_1012	COG2852	Protein conserved in bacteria
ABCA12_1015	COG0306	phosphate transporter
ABCA12_1016	COG3293	Transposase
ABCA12_1019	COG1115	amino acid carrier protein
ABCA12_1020	COG1113	amino acid transport
ABCA12_1022	COG0019	diaminopimelate decarboxylase activity
ABCA12_1023	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ABCA12_1035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ABCA12_1040	COG1671	Belongs to the UPF0178 family
ABCA12_1043	COG4591	ABC-type transport system involved in lipoprotein release permease component
ABCA12_1044	COG1136	(ABC) transporter
ABCA12_1046	COG2333	competence protein COMEC
ABCA12_1046	COG0658	competence protein
ABCA12_1048	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ABCA12_1048	COG0616	signal peptide processing
ABCA12_1050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ABCA12_1052	COG0628	permease
ABCA12_1053	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ABCA12_1059	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ABCA12_1063	COG0823	Involved in the tonB-independent uptake of proteins
ABCA12_1067	COG0824	Thioesterase
ABCA12_1072	COG0047	phosphoribosylformylglycinamidine synthase activity
ABCA12_1072	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ABCA12_1073	COG2814	Major facilitator Superfamily
ABCA12_1078	COG3323	Protein of unknown function (DUF1653)
ABCA12_1078	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ABCA12_1079	COG0778	Nitroreductase
ABCA12_1080	COG1024	Enoyl-CoA hydratase
ABCA12_1081	COG1056	cytidyltransferase-related domain
ABCA12_1081	COG1051	belongs to the nudix hydrolase family
ABCA12_1084	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ABCA12_1087	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ABCA12_1088	COG0602	queuosine metabolic process
ABCA12_1091	COG0583	DNA-binding transcription factor activity
ABCA12_1092	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ABCA12_1093	COG4208	sulfate ABC transporter
ABCA12_1094	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ABCA12_1096	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ABCA12_1097	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ABCA12_1098	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ABCA12_1101	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ABCA12_1103	COG0481	GTPase activity
ABCA12_1106	COG0571	ribonuclease III activity
ABCA12_1107	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ABCA12_1110	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ABCA12_1113	COG0436	Aminotransferase
ABCA12_1118	COG0556	nucleotide-excision repair
ABCA12_1130	COG0583	DNA-binding transcription factor activity
ABCA12_1131	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ABCA12_1132	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ABCA12_1133	COG1773	rubredoxin
ABCA12_1135	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ABCA12_1138	COG0175	sulfate reduction
ABCA12_1141	COG0222	ribosome binding
ABCA12_1142	COG1253	flavin adenine dinucleotide binding
ABCA12_1147	COG0517	IMP dehydrogenase activity
ABCA12_1147	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ABCA12_1148	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ABCA12_1150	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ABCA12_1151	COG1137	ATPase activity
ABCA12_1155	COG1538	Outer membrane efflux protein
ABCA12_1158	COG1739	Uncharacterized protein family UPF0029
ABCA12_1159	COG0110	maltose O-acetyltransferase activity
ABCA12_1163	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ABCA12_1165	COG3293	Transposase
ABCA12_1171	COG1840	ABC-type Fe3 transport system, periplasmic component
ABCA12_1172	COG3842	ATPase activity
ABCA12_1174	COG1253	flavin adenine dinucleotide binding
ABCA12_1175	COG0772	Belongs to the SEDS family
ABCA12_1178	COG0772	Belongs to the SEDS family
ABCA12_1182	COG5002	protein histidine kinase activity
ABCA12_1185	COG2351	hydroxyisourate hydrolase activity
ABCA12_1188	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ABCA12_1189	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ABCA12_1197	COG4783	chaperone-mediated protein folding
ABCA12_1200	COG1610	YqeY-like protein
ABCA12_1204	COG0697	spore germination
ABCA12_1208	COG2815	serine threonine protein kinase
ABCA12_1208	COG0515	serine threonine protein kinase
ABCA12_1209	COG1414	Transcriptional regulator
ABCA12_1214	COG1028	Short-chain dehydrogenase reductase Sdr
ABCA12_1218	COG0028	Belongs to the TPP enzyme family
ABCA12_1226	COG0482	sulfurtransferase activity
ABCA12_1229	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ABCA12_1230	COG1686	Belongs to the peptidase S11 family
ABCA12_1237	COG1067	ATP-dependent peptidase activity
ABCA12_1245	COG1509	lysine 2,3-aminomutase activity
ABCA12_1246	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ABCA12_1247	COG1966	Carbon starvation protein
ABCA12_1248	COG2879	small protein
ABCA12_1249	COG0714	Associated with various cellular activities
ABCA12_1259	COG1741	Belongs to the pirin family
ABCA12_1261	COG0446	pyridine nucleotide-disulphide oxidoreductase
ABCA12_1261	COG1902	pentaerythritol trinitrate reductase activity
ABCA12_1269	COG1960	acyl-CoA dehydrogenase activity
ABCA12_1277	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ABCA12_1279	COG4106	trans-aconitate 2-methyltransferase activity
ABCA12_1280	COG0642	Histidine kinase
ABCA12_1281	COG0745	RESPONSE REGULATOR receiver
ABCA12_1286	COG2351	hydroxyisourate hydrolase activity
ABCA12_1291	COG3293	Transposase
ABCA12_1293	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ABCA12_1298	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
ABCA12_1300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ABCA12_1301	COG1116	anion transmembrane transporter activity
ABCA12_1303	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ABCA12_1309	COG2188	Transcriptional regulator
ABCA12_1315	COG0010	Belongs to the arginase family
ABCA12_1316	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ABCA12_1320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ABCA12_1325	COG1309	transcriptional regulator
ABCA12_1329	COG2072	flavoprotein involved in K transport
ABCA12_1330	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ABCA12_1331	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ABCA12_1332	COG1984	allophanate hydrolase subunit 2
ABCA12_1333	COG4770	biotin carboxylase activity
ABCA12_1334	COG0501	Belongs to the peptidase M48B family
ABCA12_1336	COG1765	OsmC-like protein
ABCA12_1346	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ABCA12_1350	COG3634	alkyl hydroperoxide reductase activity
ABCA12_1353	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ABCA12_1357	COG1643	Atp-dependent helicase
ABCA12_1361	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ABCA12_1362	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ABCA12_1366	COG2951	lytic endotransglycosylase activity
ABCA12_1367	COG0772	Belongs to the SEDS family
ABCA12_1370	COG0842	Transport permease protein
ABCA12_1371	COG1131	(ABC) transporter
ABCA12_1377	COG2801	Transposase and inactivated derivatives
ABCA12_1380	COG3177	Filamentation induced by cAMP protein fic
ABCA12_1382	COG2186	Transcriptional regulator
ABCA12_1384	COG0277	FAD linked oxidase domain protein
ABCA12_1388	COG4221	oxidoreductase activity
ABCA12_1389	COG0583	DNA-binding transcription factor activity
ABCA12_1390	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ABCA12_1394	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ABCA12_1396	COG1979	alcohol dehydrogenase
ABCA12_1399	COG1309	transcriptional regulator
ABCA12_1403	COG2801	Transposase and inactivated derivatives
ABCA12_1405	COG3293	Transposase
ABCA12_1415	COG3539	Fimbrial protein
ABCA12_1416	COG3293	Transposase
ABCA12_1421	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ABCA12_1421	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ABCA12_1424	COG1278	Cold shock
ABCA12_1432	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ABCA12_1433	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ABCA12_1435	COG2353	YceI-like domain
ABCA12_1437	COG3811	Belongs to the UPF0386 family
ABCA12_1438	COG0590	tRNA wobble adenosine to inosine editing
ABCA12_1440	COG3698	Phosphodiester glycosidase
ABCA12_1442	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ABCA12_1444	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ABCA12_1444	COG0506	proline dehydrogenase activity
ABCA12_1444	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ABCA12_1446	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ABCA12_1450	COG1132	(ABC) transporter
ABCA12_1453	COG0668	transmembrane transport
ABCA12_1454	COG3122	Protein conserved in bacteria
ABCA12_1463	COG2850	peptidyl-arginine hydroxylation
ABCA12_1464	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ABCA12_1465	COG0824	Thioesterase
ABCA12_1466	COG1454	alcohol dehydrogenase
ABCA12_1467	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ABCA12_1474	COG0069	glutamate synthase activity
ABCA12_1478	COG0625	glutathione transferase activity
ABCA12_1480	COG1113	amino acid transport
ABCA12_1481	COG2814	Major facilitator Superfamily
ABCA12_1487	COG1116	anion transmembrane transporter activity
ABCA12_1487	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ABCA12_1489	COG2223	nitrite transmembrane transporter activity
ABCA12_1490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ABCA12_1490	COG2146	nitrite reductase [NAD(P)H] activity
ABCA12_1491	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ABCA12_1492	COG0243	molybdopterin cofactor binding
ABCA12_1497	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ABCA12_1501	COG0521	Mo-molybdopterin cofactor biosynthetic process
ABCA12_1501	COG0315	cyclic pyranopterin monophosphate synthase activity
ABCA12_1502	COG0303	'Molybdopterin
ABCA12_1518	COG2204	response regulator
ABCA12_1519	COG3852	Histidine kinase
ABCA12_1522	COG0233	cytoplasmic translational termination
ABCA12_1523	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ABCA12_1524	COG0575	Belongs to the CDS family
ABCA12_1529	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ABCA12_1531	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ABCA12_1532	COG2207	Transcriptional regulator
ABCA12_1533	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ABCA12_1535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ABCA12_1536	COG1960	acyl-CoA dehydrogenase activity
ABCA12_1537	COG1960	acyl-CoA dehydrogenase activity
ABCA12_1540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ABCA12_1546	COG2223	nitrite transmembrane transporter activity
ABCA12_1549	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ABCA12_1552	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ABCA12_1560	COG4771	TonB-dependent receptor
ABCA12_1563	COG0730	response to heat
ABCA12_1567	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ABCA12_1572	COG0537	adenosine 5'-monophosphoramidase activity
ABCA12_1578	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ABCA12_1582	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ABCA12_1584	COG0133	tryptophan synthase activity
ABCA12_1587	COG3706	GGDEF domain
ABCA12_1596	COG3293	Transposase
ABCA12_1600	COG2801	Transposase and inactivated derivatives
ABCA12_1602	COG1401	restriction endodeoxyribonuclease activity
ABCA12_1603	COG4628	conserved protein (DUF2132)
ABCA12_1607	COG0730	response to heat
ABCA12_1608	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ABCA12_1613	COG0583	DNA-binding transcription factor activity
ABCA12_1617	COG2814	Major facilitator Superfamily
ABCA12_1620	COG0318	PFAM AMP-dependent synthetase and ligase
ABCA12_1621	COG1309	transcriptional regulator
ABCA12_1622	COG1960	acyl-CoA dehydrogenase activity
ABCA12_1625	COG1024	Enoyl-CoA hydratase
ABCA12_1626	COG4770	biotin carboxylase activity
ABCA12_1628	COG0583	DNA-binding transcription factor activity
ABCA12_1633	COG4372	Transposase
ABCA12_1635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ABCA12_1637	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ABCA12_1638	COG0864	Transcriptional regulator
ABCA12_1640	COG1196	nuclear chromosome segregation
ABCA12_1641	COG0439	Biotin carboxylase
ABCA12_1644	COG1522	sequence-specific DNA binding
ABCA12_1651	COG1944	ATP diphosphatase activity
ABCA12_1653	COG0583	DNA-binding transcription factor activity
ABCA12_1654	COG4948	Mandelate Racemase Muconate Lactonizing
ABCA12_1655	COG4829	muconolactone delta-isomerase
ABCA12_1657	COG4638	Rieske (2fe-2S)
ABCA12_1658	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ABCA12_1659	COG0633	Ferredoxin
ABCA12_1659	COG0543	2 iron, 2 sulfur cluster binding
ABCA12_1660	COG1028	Short-chain dehydrogenase reductase Sdr
ABCA12_1661	COG3135	benzoate transporter
ABCA12_1662	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ABCA12_1663	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ABCA12_1664	COG0183	Belongs to the thiolase family
ABCA12_1665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ABCA12_1668	COG2814	Major facilitator Superfamily
ABCA12_1670	COG1454	alcohol dehydrogenase
ABCA12_1674	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ABCA12_1676	COG1063	alcohol dehydrogenase
ABCA12_1677	COG2207	Transcriptional regulator
ABCA12_1679	COG1802	Transcriptional regulator
ABCA12_1682	COG2801	Transposase and inactivated derivatives
ABCA12_1690	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ABCA12_1691	COG0148	phosphopyruvate hydratase activity
ABCA12_1700	COG0446	pyridine nucleotide-disulphide oxidoreductase
ABCA12_1700	COG1902	pentaerythritol trinitrate reductase activity
ABCA12_1702	COG2267	carboxylic ester hydrolase activity
ABCA12_1704	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ABCA12_1705	COG0488	(ABC) transporter
ABCA12_1707	COG0542	response to heat
ABCA12_1709	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ABCA12_1714	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ABCA12_1715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ABCA12_1716	COG0569	domain protein
ABCA12_1717	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ABCA12_1721	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ABCA12_1726	COG1294	oxidase, subunit
ABCA12_1730	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ABCA12_1733	COG0552	protein localization to endoplasmic reticulum
ABCA12_1738	COG0517	IMP dehydrogenase activity
ABCA12_1738	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ABCA12_1739	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ABCA12_1740	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ABCA12_1742	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ABCA12_1743	COG0583	DNA-binding transcription factor activity
ABCA12_1744	COG0024	Methionine aminopeptidase
ABCA12_1751	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ABCA12_1752	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ABCA12_1760	COG4372	Transposase
ABCA12_1762	COG0776	regulation of translation
ABCA12_1777	COG0084	hydrolase, TatD family'
ABCA12_1781	COG1663	tetraacyldisaccharide 4'-kinase activity
ABCA12_1782	COG1132	(ABC) transporter
ABCA12_1784	COG0811	peptide transport
ABCA12_1785	COG1475	DNA binding
ABCA12_1786	COG1192	Involved in chromosome partitioning
ABCA12_1788	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ABCA12_1789	COG3178	'Phosphotransferase
ABCA12_1791	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ABCA12_1793	COG0513	Belongs to the DEAD box helicase family
ABCA12_1807	COG4650	regulator
ABCA12_1808	COG1234	tRNA 3'-trailer cleavage
ABCA12_1809	COG1234	tRNA 3'-trailer cleavage
ABCA12_1810	COG1690	Belongs to the RtcB family
ABCA12_1814	COG2195	Cleaves the N-terminal amino acid of tripeptides
ABCA12_1818	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ABCA12_1820	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ABCA12_1824	COG1960	acyl-CoA dehydrogenase activity
ABCA12_1836	COG3139	Protein of unknown function (DUF1315)
ABCA12_1837	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ABCA12_1838	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ABCA12_1840	COG0494	nUDIX hydrolase
ABCA12_1842	COG0642	Histidine kinase
ABCA12_1844	COG2205	protein histidine kinase activity
ABCA12_1844	COG0784	Response regulator, receiver
ABCA12_1846	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ABCA12_1850	COG1720	tRNA m6t6A37 methyltransferase activity
ABCA12_1854	COG3293	Transposase
ABCA12_1856	COG0583	DNA-binding transcription factor activity
ABCA12_1857	COG2814	Major facilitator Superfamily
ABCA12_1858	COG3647	Membrane
ABCA12_1861	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ABCA12_1869	COG0729	surface antigen
ABCA12_1874	COG3293	Transposase
ABCA12_1877	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ABCA12_1880	COG2801	Transposase and inactivated derivatives
ABCA12_1883	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ABCA12_1886	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ABCA12_1889	COG2808	Putative FMN-binding domain
ABCA12_1892	COG4682	membrane
ABCA12_1895	COG0826	peptidase U32
ABCA12_1896	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ABCA12_1902	COG2801	Transposase and inactivated derivatives
ABCA12_1904	COG2963	transposase activity
ABCA12_1906	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ABCA12_1913	COG4372	Transposase
ABCA12_1925	COG1560	Kdo2-lipid A biosynthetic process
ABCA12_1930	COG0204	Acyl-transferase
ABCA12_1937	COG1464	Belongs to the NlpA lipoprotein family
ABCA12_1938	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ABCA12_1939	COG2011	ABC-type metal ion transport system permease component
ABCA12_1940	COG0012	GTP binding
ABCA12_1943	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ABCA12_1953	COG0386	Belongs to the glutathione peroxidase family
ABCA12_1955	COG0436	Aminotransferase
ABCA12_1963	COG2267	carboxylic ester hydrolase activity
ABCA12_1964	COG3634	alkyl hydroperoxide reductase activity
ABCA12_1974	COG1286	toxin biosynthetic process
ABCA12_1980	COG0778	Nitroreductase
ABCA12_1985	COG0424	maF-like protein
ABCA12_1988	COG2801	Transposase and inactivated derivatives
ABCA12_1993	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ABCA12_1994	COG2030	dehydratase
ABCA12_1999	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ABCA12_2000	COG0702	epimerase
ABCA12_2001	COG0268	Binds directly to 16S ribosomal RNA
ABCA12_2006	COG1011	Hydrolase
ABCA12_2007	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ABCA12_2009	COG2137	regulation of response to DNA damage stimulus
ABCA12_2011	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ABCA12_2017	COG0822	iron-sulfur transferase activity
ABCA12_2018	COG0316	Belongs to the HesB IscA family
ABCA12_2024	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ABCA12_2027	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ABCA12_2029	COG3135	benzoate transporter
ABCA12_2030	COG0475	glutathione-regulated potassium exporter activity
ABCA12_2030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ABCA12_2031	COG1714	RDD family
ABCA12_2033	COG1760	l-serine dehydratase
ABCA12_2034	COG0308	aminopeptidase N
ABCA12_2045	COG3409	Peptidoglycan-binding domain 1 protein
ABCA12_2045	COG3501	Rhs element vgr protein
ABCA12_2047	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ABCA12_2051	COG0519	Catalyzes the synthesis of GMP from XMP
ABCA12_2051	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ABCA12_2059	COG0697	spore germination
ABCA12_2060	COG1923	regulation of RNA biosynthetic process
ABCA12_2062	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ABCA12_2063	COG0802	atpase or kinase
ABCA12_2065	COG0564	pseudouridine synthase activity
ABCA12_2071	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ABCA12_2076	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ABCA12_2077	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ABCA12_2078	COG1845	cytochrome c oxidase, subunit III
ABCA12_2079	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ABCA12_2086	COG0305	Participates in initiation and elongation during chromosome replication
ABCA12_2087	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ABCA12_2089	COG1305	Transglutaminase-like
ABCA12_2091	COG2308	Evidence 4 Homologs of previously reported genes of
ABCA12_2093	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ABCA12_2096	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ABCA12_2098	COG0527	aspartate kinase activity
ABCA12_2100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ABCA12_2103	COG3038	cytochrome b561
ABCA12_2104	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ABCA12_2105	COG2252	PERMEase
ABCA12_2117	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ABCA12_2118	COG0138	bifunctional purine biosynthesis protein purh
ABCA12_2119	COG0151	Belongs to the GarS family
ABCA12_2121	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ABCA12_2122	COG2011	ABC-type metal ion transport system permease component
ABCA12_2127	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ABCA12_2129	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ABCA12_2131	COG0281	malic enzyme
ABCA12_2131	COG0280	phosphate acetyltransferase
ABCA12_2134	COG0052	Belongs to the universal ribosomal protein uS2 family
ABCA12_2135	COG0024	Methionine aminopeptidase
ABCA12_2137	COG2223	nitrite transmembrane transporter activity
ABCA12_2139	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ABCA12_2140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ABCA12_2141	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ABCA12_2145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ABCA12_2146	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ABCA12_2147	COG3161	chorismate lyase activity
ABCA12_2148	COG0174	glutamine synthetase
ABCA12_2149	COG0512	Glutamine amidotransferase of anthranilate synthase
ABCA12_2150	COG1823	symporter activity
ABCA12_2151	COG3217	Mosc domain protein beta barrel domain protein
ABCA12_2151	COG0633	Ferredoxin
ABCA12_2154	COG3293	Transposase
ABCA12_2157	COG0302	gtp cyclohydrolase
ABCA12_2163	COG3739	integral membrane protein
ABCA12_2169	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ABCA12_2172	COG4172	Belongs to the ABC transporter superfamily
ABCA12_2173	COG4239	(ABC) transporter, permease
ABCA12_2174	COG4174	ABC transporter (Permease)
ABCA12_2175	COG4166	transmembrane transport
ABCA12_2176	COG0741	lytic transglycosylase activity
ABCA12_2176	COG1388	LysM domain
ABCA12_2177	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ABCA12_2189	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ABCA12_2190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ABCA12_2191	COG0006	proline dipeptidase activity
ABCA12_2197	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ABCA12_2201	COG0714	Associated with various cellular activities
ABCA12_2207	COG2801	Transposase and inactivated derivatives
ABCA12_2211	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ABCA12_2214	COG3384	dioxygenase
ABCA12_2216	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ABCA12_2217	COG2878	Part of a membrane complex involved in electron transport
ABCA12_2218	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ABCA12_2223	COG0768	penicillin binding
ABCA12_2224	COG0742	ribosomal rna small subunit methyltransferase
ABCA12_2231	COG0616	signal peptide processing
ABCA12_2233	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ABCA12_2235	COG0573	inorganic phosphate transmembrane transporter activity
ABCA12_2238	COG0076	glutamate decarboxylase activity
ABCA12_2239	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ABCA12_2241	COG1309	transcriptional regulator
ABCA12_2245	COG1309	transcriptional regulator
ABCA12_2248	COG0783	Belongs to the Dps family
ABCA12_2251	COG0564	pseudouridine synthase activity
ABCA12_2253	COG0352	thiamine-phosphate diphosphorylase activity
ABCA12_2259	COG1203	CRISPR-associated helicase, Cas3
ABCA12_2268	COG0612	Peptidase, M16
ABCA12_2269	COG0384	phenazine biosynthesis protein PhzF
ABCA12_2271	COG1187	pseudouridine synthase activity
ABCA12_2275	COG1686	Belongs to the peptidase S11 family
ABCA12_2276	COG1252	NADH dehydrogenase
ABCA12_2278	COG0415	Belongs to the DNA photolyase family
ABCA12_2282	COG1271	oxidase subunit
ABCA12_2284	COG1294	oxidase, subunit
ABCA12_2286	COG2070	2-Nitropropane dioxygenase
ABCA12_2289	COG0457	Tetratricopeptide repeat
ABCA12_2289	COG0705	Rhomboid family
ABCA12_2291	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ABCA12_2292	COG4181	ATPase activity
ABCA12_2294	COG0288	reversible hydration of carbon dioxide
ABCA12_2297	COG4771	TonB-dependent receptor
ABCA12_2298	COG4771	TonB-dependent receptor
ABCA12_2301	COG3293	Transposase
ABCA12_2304	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ABCA12_2311	COG1597	lipid kinase activity
ABCA12_2312	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ABCA12_2315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ABCA12_2317	COG2388	GCN5-related N-acetyl-transferase
ABCA12_2322	COG1215	transferase activity, transferring glycosyl groups
ABCA12_2323	COG1649	PFAM Uncharacterised BCR, COG1649
ABCA12_2323	COG0726	polysaccharide deacetylase
ABCA12_2326	COG4681	YaeQ
ABCA12_2327	COG0523	cobalamin synthesis protein
ABCA12_2329	COG1607	acyl-coa hydrolase
ABCA12_2335	COG0583	DNA-binding transcription factor activity
ABCA12_2338	COG0582	viral genome integration into host DNA
ABCA12_2343	COG2814	Major facilitator Superfamily
ABCA12_2360	COG3311	Transcriptional regulator
ABCA12_2364	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ABCA12_2369	COG2132	Multicopper oxidase
ABCA12_2372	COG2205	protein histidine kinase activity
ABCA12_2373	COG2217	Heavy metal translocating P-type atpase
ABCA12_2377	COG2184	nucleotidyltransferase activity
ABCA12_2384	COG0789	Transcriptional regulator
ABCA12_2393	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ABCA12_2394	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ABCA12_2397	COG0741	lytic transglycosylase activity
ABCA12_2398	COG0501	Belongs to the peptidase M48B family
ABCA12_2400	COG2239	Acts as a magnesium transporter
ABCA12_2402	COG2194	sulfuric ester hydrolase activity
ABCA12_2403	COG0584	glycerophosphoryl diester phosphodiesterase
ABCA12_2408	COG2304	oxidoreductase activity
ABCA12_2409	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ABCA12_2410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ABCA12_2415	COG0505	Belongs to the CarA family
ABCA12_2420	COG0589	response to stress
ABCA12_2425	COG4372	Transposase
ABCA12_2428	COG0025	NhaP-type Na H and K H
ABCA12_2429	COG2321	neutral zinc metallopeptidase
ABCA12_2430	COG2354	Protein conserved in bacteria
ABCA12_2432	COG1585	Membrane protein implicated in regulation of membrane protease activity
ABCA12_2433	COG2268	Band 7 protein
ABCA12_2436	COG0154	amidase activity
ABCA12_2438	COG2268	Band 7 protein
ABCA12_2442	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ABCA12_2445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ABCA12_2446	COG1053	succinate dehydrogenase
ABCA12_2447	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ABCA12_2448	COG2009	succinate dehydrogenase
ABCA12_2454	COG1054	Belongs to the UPF0176 family
ABCA12_2455	COG0586	Pfam SNARE associated Golgi protein
ABCA12_2466	COG0321	lipoyl(octanoyl) transferase activity
ABCA12_2469	COG0531	amino acid
ABCA12_2472	COG1733	regulation of RNA biosynthetic process
ABCA12_2473	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ABCA12_2474	COG1648	precorrin-2 dehydrogenase activity
ABCA12_2474	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ABCA12_2477	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ABCA12_2483	COG0671	phosphoesterase, PA-phosphatase related
ABCA12_2484	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ABCA12_2487	COG1538	Outer membrane efflux protein
ABCA12_2488	COG0393	Putative heavy-metal-binding
ABCA12_2489	COG0393	Putative heavy-metal-binding
ABCA12_2491	COG1028	Short-chain dehydrogenase reductase Sdr
ABCA12_2493	COG0525	valine-tRNA ligase activity
ABCA12_2495	COG0004	ammonium transporteR
ABCA12_2498	COG0642	Histidine kinase
ABCA12_2499	COG0745	RESPONSE REGULATOR receiver
ABCA12_2500	COG2194	sulfuric ester hydrolase activity
ABCA12_2505	COG1752	Esterase of the alpha-beta hydrolase superfamily
ABCA12_2508	COG2814	Major facilitator Superfamily
ABCA12_2509	COG0142	geranyltranstransferase activity
ABCA12_2511	COG1113	amino acid transport
ABCA12_2512	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ABCA12_2513	COG0210	DNA helicase
ABCA12_2515	COG0174	glutamine synthetase
ABCA12_2516	COG0671	phosphoesterase, PA-phosphatase related
ABCA12_2518	COG2851	Citrate transporter
ABCA12_2524	COG0745	RESPONSE REGULATOR receiver
ABCA12_2525	COG2205	protein histidine kinase activity
ABCA12_2526	COG2205	protein histidine kinase activity
ABCA12_2528	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ABCA12_2529	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ABCA12_2530	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ABCA12_2533	COG0560	Phosphoserine phosphatase
ABCA12_2535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ABCA12_2537	COG1530	ribonuclease E activity
ABCA12_2538	COG0424	maF-like protein
ABCA12_2540	COG1792	Involved in formation and maintenance of cell shape
ABCA12_2541	COG1077	Cell shape determining protein MreB Mrl
ABCA12_2542	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ABCA12_2544	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ABCA12_2549	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ABCA12_2557	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
ABCA12_2558	COG1752	Esterase of the alpha-beta hydrolase superfamily
ABCA12_2559	COG1115	amino acid carrier protein
ABCA12_2564	COG2814	Major facilitator Superfamily
ABCA12_2565	COG1289	transmembrane transporter activity
ABCA12_2571	COG1376	ErfK ybiS ycfS ynhG family protein
ABCA12_2572	COG2832	Protein of unknown function (DUF454)
ABCA12_2574	COG5510	response to toxic substance
ABCA12_2577	COG2198	Histidine kinase
ABCA12_2577	COG0643	Histidine kinase
ABCA12_2577	COG0643	Histidine kinase
ABCA12_2577	COG2198	Histidine kinase
ABCA12_2578	COG0840	transmembrane signaling receptor activity
ABCA12_2584	COG3422	double-strand break repair
ABCA12_2585	COG2824	Alkylphosphonate utilization operon protein PhnA
ABCA12_2586	COG3189	MarR family transcriptional regulator
ABCA12_2588	COG0354	folic acid binding
ABCA12_2590	COG4772	TonB-dependent receptor
ABCA12_2592	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ABCA12_2595	COG1217	gtp-binding protein TYPA
ABCA12_2596	COG2233	PERMEase
ABCA12_2598	COG0833	amino acid
ABCA12_2599	COG1690	Belongs to the RtcB family
ABCA12_2603	COG0183	Belongs to the thiolase family
ABCA12_2607	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ABCA12_2610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABCA12_2611	COG2207	Transcriptional regulator
ABCA12_2614	COG0183	Belongs to the thiolase family
ABCA12_2621	COG1272	protein, Hemolysin III
ABCA12_2622	COG0477	Major facilitator Superfamily
ABCA12_2626	COG0450	alkyl hydroperoxide reductase
ABCA12_2631	COG0285	dihydrofolate synthase activity
ABCA12_2642	COG4206	TonB-dependent receptor
ABCA12_2643	COG2096	Adenosyltransferase
ABCA12_2647	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ABCA12_2650	COG0745	RESPONSE REGULATOR receiver
ABCA12_2651	COG2205	protein histidine kinase activity
ABCA12_2653	COG1960	acyl-CoA dehydrogenase activity
ABCA12_2654	COG1960	acyl-CoA dehydrogenase activity
ABCA12_2668	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ABCA12_2676	COG0438	transferase activity, transferring glycosyl groups
ABCA12_2680	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ABCA12_2681	COG2205	protein histidine kinase activity
ABCA12_2681	COG0784	Response regulator, receiver
ABCA12_2682	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ABCA12_2686	COG1862	Preprotein translocase
ABCA12_2702	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ABCA12_2703	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ABCA12_2704	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ABCA12_2707	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ABCA12_2708	COG0625	glutathione transferase activity
ABCA12_2709	COG2969	positive regulation of protein catabolic process
ABCA12_2718	COG3293	Transposase
ABCA12_2725	COG1960	acyl-CoA dehydrogenase activity
ABCA12_2726	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ABCA12_2729	COG1309	transcriptional regulator
ABCA12_2731	COG1960	acyl-CoA dehydrogenase activity
ABCA12_2732	COG1960	acyl-CoA dehydrogenase activity
ABCA12_2733	COG1960	acyl-CoA dehydrogenase activity
ABCA12_2738	COG1183	phosphatidylcholine synthase activity
ABCA12_2739	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ABCA12_2745	COG1196	nuclear chromosome segregation
ABCA12_2745	COG0741	lytic transglycosylase activity
ABCA12_2745	COG0739	heme binding
ABCA12_2747	COG1702	phosphate starvation-inducible protein PhoH
ABCA12_2751	COG4773	Receptor
ABCA12_2764	COG0788	formyltetrahydrofolate deformylase activity
ABCA12_2769	COG4651	solute:proton antiporter activity
ABCA12_2769	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ABCA12_2773	COG0724	RNA recognition motif
ABCA12_2774	COG0210	DNA helicase
ABCA12_2781	COG2900	Belongs to the SlyX family
ABCA12_2782	COG0488	(ABC) transporter
ABCA12_2784	COG1560	Kdo2-lipid A biosynthetic process
ABCA12_2795	COG0473	3-isopropylmalate dehydrogenase activity
ABCA12_2800	COG0583	DNA-binding transcription factor activity
ABCA12_2805	COG0494	nUDIX hydrolase
ABCA12_2809	COG3011	Protein conserved in bacteria
ABCA12_2812	COG0583	DNA-binding transcription factor activity
ABCA12_2817	COG1530	ribonuclease E activity
ABCA12_2818	COG0318	PFAM AMP-dependent synthetase and ligase
ABCA12_2820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ABCA12_2824	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ABCA12_2833	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ABCA12_2836	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ABCA12_2836	COG0493	'glutamate synthase
ABCA12_2840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ABCA12_2844	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ABCA12_2846	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
ABCA12_2846	COG0644	oxidoreductase
ABCA12_2848	COG1595	DNA-templated transcription, initiation
ABCA12_2850	COG3220	belongs to the UPF0276 family
ABCA12_2853	COG1279	arginine transmembrane transporter activity
ABCA12_2854	COG0425	Belongs to the sulfur carrier protein TusA family
ABCA12_2855	COG4535	Mg2 and Co2 transporter CorC
ABCA12_2860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ABCA12_2862	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ABCA12_2865	COG0789	Transcriptional regulator
ABCA12_2866	COG0598	Magnesium transport protein CorA
ABCA12_2867	COG1185	polyribonucleotide nucleotidyltransferase activity
ABCA12_2868	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ABCA12_2869	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ABCA12_2870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ABCA12_2873	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ABCA12_2878	COG2226	methyltransferase
ABCA12_2880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ABCA12_2883	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ABCA12_2886	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ABCA12_2889	COG2111	Na H antiporter
ABCA12_2889	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ABCA12_2890	COG1006	Multisubunit Na H antiporter MnhC subunit
ABCA12_2891	COG0651	ATP synthesis coupled electron transport
ABCA12_2892	COG1863	multisubunit Na H antiporter MnhE subunit
ABCA12_2893	COG2212	antiporter activity
ABCA12_2894	COG1320	monovalent cation:proton antiporter activity
ABCA12_2895	COG4372	Transposase
ABCA12_2898	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ABCA12_2900	COG0195	Participates in both transcription termination and antitermination
ABCA12_2907	COG0237	dephospho-CoA kinase activity
ABCA12_2909	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ABCA12_2911	COG0497	DNA recombination
ABCA12_2913	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ABCA12_2918	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ABCA12_2924	COG3706	GGDEF domain
ABCA12_2931	COG1132	(ABC) transporter
ABCA12_2935	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ABCA12_2938	COG0326	Molecular chaperone. Has ATPase activity
ABCA12_2941	COG2056	Na+-H+ antiporter family
ABCA12_2950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ABCA12_2953	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ABCA12_2955	COG0546	phosphoglycolate phosphatase activity
ABCA12_2956	COG1716	ATPase activity
ABCA12_2966	COG0181	hydroxymethylbilane synthase activity
ABCA12_2968	COG3275	phosphorelay sensor kinase activity
ABCA12_2975	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ABCA12_2976	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ABCA12_2977	COG0772	Belongs to the SEDS family
ABCA12_2982	COG4974	Belongs to the 'phage' integrase family
ABCA12_2983	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ABCA12_2985	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ABCA12_2989	COG2197	response regulator
ABCA12_2993	COG0793	Belongs to the peptidase S41A family
ABCA12_2994	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ABCA12_2995	COG0795	lipopolysaccharide-transporting ATPase activity
ABCA12_2996	COG0795	lipopolysaccharide-transporting ATPase activity
ABCA12_3003	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ABCA12_3003	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ABCA12_3005	COG0004	ammonium transporteR
ABCA12_3006	COG0347	Belongs to the P(II) protein family
ABCA12_3012	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ABCA12_3015	COG0318	PFAM AMP-dependent synthetase and ligase
ABCA12_3017	COG2860	membrane
ABCA12_3019	COG1253	flavin adenine dinucleotide binding
ABCA12_3022	COG2814	Major facilitator Superfamily
ABCA12_3025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ABCA12_3026	COG0745	RESPONSE REGULATOR receiver
ABCA12_3027	COG2205	protein histidine kinase activity
ABCA12_3028	COG4452	Inner membrane protein CreD
ABCA12_3033	COG2814	Major facilitator Superfamily
ABCA12_3034	COG2814	Major facilitator Superfamily
ABCA12_3038	COG0655	NAD(P)H dehydrogenase (quinone) activity
ABCA12_3042	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ABCA12_3043	COG1283	sodium-dependent phosphate transmembrane transporter activity
ABCA12_3044	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ABCA12_3048	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ABCA12_3049	COG3162	membrane
ABCA12_3050	COG2205	protein histidine kinase activity
ABCA12_3050	COG0784	Response regulator, receiver
ABCA12_3055	COG1652	LysM domain
ABCA12_3056	COG0758	DNA mediated transformation
ABCA12_3059	COG1309	transcriptional regulator
ABCA12_3063	COG0386	Belongs to the glutathione peroxidase family
ABCA12_3067	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ABCA12_3075	COG0803	Belongs to the bacterial solute-binding protein 9 family
ABCA12_3077	COG1121	(ABC) transporter
ABCA12_3078	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ABCA12_3079	COG1280	lysine exporter protein (LysE YggA)
ABCA12_3080	COG2837	iron assimilation
ABCA12_3082	COG0281	malic enzyme
ABCA12_3090	COG0519	Catalyzes the synthesis of GMP from XMP
ABCA12_3090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ABCA12_3091	COG4399	Belongs to the UPF0754 family
ABCA12_3096	COG0586	Pfam SNARE associated Golgi protein
ABCA12_3099	COG1192	Involved in chromosome partitioning
ABCA12_3101	COG0271	Belongs to the BolA IbaG family
ABCA12_3106	COG3756	Protein conserved in bacteria
ABCA12_3109	COG0494	nUDIX hydrolase
ABCA12_3119	COG3550	peptidyl-serine autophosphorylation
ABCA12_3120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ABCA12_3130	COG4372	Transposase
ABCA12_3131	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ABCA12_3139	COG0477	Major facilitator Superfamily
ABCA12_3140	COG1024	Enoyl-CoA hydratase
ABCA12_3141	COG1024	Enoyl-CoA hydratase
ABCA12_3142	COG1960	acyl-CoA dehydrogenase activity
ABCA12_3143	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ABCA12_3147	COG1113	amino acid transport
ABCA12_3148	COG0251	oxidation-reduction process
ABCA12_3155	COG0564	pseudouridine synthase activity
ABCA12_3165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ABCA12_3168	COG1802	Transcriptional regulator
ABCA12_3169	COG1448	Aminotransferase
ABCA12_3170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ABCA12_3171	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ABCA12_3174	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ABCA12_3177	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ABCA12_3183	COG0438	transferase activity, transferring glycosyl groups
ABCA12_3187	COG0438	transferase activity, transferring glycosyl groups
ABCA12_3191	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ABCA12_3192	COG1596	polysaccharide export
ABCA12_3196	COG0545	Peptidyl-prolyl cis-trans isomerase
ABCA12_3198	COG3023	N-Acetylmuramoyl-L-alanine amidase
ABCA12_3201	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ABCA12_3208	COG0546	phosphoglycolate phosphatase activity
ABCA12_3209	COG1028	Short-chain dehydrogenase reductase Sdr
ABCA12_3211	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ABCA12_3211	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ABCA12_3212	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ABCA12_3213	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ABCA12_3214	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ABCA12_3215	COG1116	anion transmembrane transporter activity
ABCA12_3216	COG1309	transcriptional regulator
ABCA12_3219	COG0196	riboflavin kinase activity
ABCA12_3220	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ABCA12_3222	COG1047	Peptidyl-prolyl cis-trans
ABCA12_3224	COG0653	protein targeting
ABCA12_3227	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ABCA12_3228	COG0657	acetylesterase activity
ABCA12_3231	COG0583	DNA-binding transcription factor activity
ABCA12_3233	COG0443	Heat shock 70 kDa protein
ABCA12_3234	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ABCA12_3242	COG2951	lytic endotransglycosylase activity
ABCA12_3243	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ABCA12_3247	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ABCA12_3251	COG1960	acyl-CoA dehydrogenase activity
ABCA12_3252	COG0583	DNA-binding transcription factor activity
ABCA12_3255	COG0861	Integral membrane protein TerC family
ABCA12_3257	COG0754	glutathionylspermidine amidase activity
ABCA12_3259	COG0402	S-adenosylhomocysteine deaminase activity
ABCA12_3266	COG0706	membrane insertase activity