locus-tag	class	description
H2677_00025	COG0187	DNA topoisomerase II activity
H2677_00035	COG0586	Pfam SNARE associated Golgi protein
H2677_00040	COG0488	(ABC) transporter
H2677_00075	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H2677_00080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H2677_00125	COG1012	belongs to the aldehyde dehydrogenase family
H2677_00130	COG0733	neurotransmitter:sodium symporter activity
H2677_00165	COG0583	DNA-binding transcription factor activity
H2677_00170	COG1028	Short-chain dehydrogenase reductase Sdr
H2677_00175	COG2233	PERMEase
H2677_00185	COG1309	transcriptional regulator
H2677_00190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2677_00220	COG2814	Major facilitator Superfamily
H2677_00225	COG0656	L-ascorbic acid biosynthetic process
H2677_00230	COG0583	DNA-binding transcription factor activity
H2677_00240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2677_00245	COG1064	alcohol dehydrogenase
H2677_00250	COG2818	Glycosylase
H2677_00260	COG0739	heme binding
H2677_00275	COG5487	UPF0391 membrane protein
H2677_00280	COG2983	Belongs to the UPF0260 family
H2677_00285	COG2133	pyrroloquinoline quinone binding
H2677_00295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H2677_00310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H2677_00320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2677_00325	COG1335	isochorismatase
H2677_00340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H2677_00350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H2677_00355	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H2677_00360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H2677_00380	COG0560	Phosphoserine phosphatase
H2677_00380	COG3830	Belongs to the UPF0237 family
H2677_00425	COG0583	DNA-binding transcription factor activity
H2677_00460	COG0534	Mate efflux family protein
H2677_00465	COG0436	Aminotransferase
H2677_00475	COG2733	membrane
H2677_00490	COG2918	glutathione biosynthetic process
H2677_00530	COG3150	esterase
H2677_00545	COG0534	Mate efflux family protein
H2677_00580	COG1247	-acetyltransferase
H2677_00630	COG1393	Belongs to the ArsC family
H2677_00635	COG0708	Exodeoxyribonuclease III
H2677_00670	COG0386	Belongs to the glutathione peroxidase family
H2677_00675	COG0189	ligase activity
H2677_00695	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H2677_00705	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H2677_00740	COG2119	membrane
H2677_00745	COG4774	siderophore transport
H2677_00750	COG0426	domain, Protein
H2677_00750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2677_00770	COG0259	pyridoxamine-phosphate oxidase activity
H2677_00775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H2677_00800	COG1902	pentaerythritol trinitrate reductase activity
H2677_00805	COG1519	Transferase
H2677_00810	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H2677_00815	COG0668	transmembrane transport
H2677_00825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2677_00830	COG1335	isochorismatase
H2677_00870	COG1309	transcriptional regulator
H2677_00875	COG0604	alcohol dehydrogenase
H2677_00875	COG3321	synthase
H2677_00875	COG1028	Short-chain dehydrogenase reductase Sdr
H2677_00885	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H2677_00895	COG2814	Major facilitator Superfamily
H2677_00900	COG0629	single-stranded DNA binding
H2677_00905	COG1113	amino acid transport
H2677_00915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H2677_00920	COG1012	belongs to the aldehyde dehydrogenase family
H2677_00930	COG1335	isochorismatase
H2677_00940	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H2677_01005	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H2677_01025	COG2329	Antibiotic biosynthesis monooxygenase
H2677_01035	COG1396	sequence-specific DNA binding
H2677_01055	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H2677_01085	COG0427	acetyl-CoA hydrolase
H2677_01130	COG0477	Major facilitator Superfamily
H2677_01135	COG0789	Transcriptional regulator
H2677_01140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2677_01140	COG3320	Male sterility
H2677_01145	COG4221	oxidoreductase activity
H2677_01155	COG0488	(ABC) transporter
H2677_01235	COG0833	amino acid
H2677_01260	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H2677_01280	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H2677_01285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H2677_01295	COG2226	methyltransferase
H2677_01345	COG0070	glutamate synthase
H2677_01345	COG0069	glutamate synthase activity
H2677_01345	COG0067	glutamate synthase
H2677_01350	COG0493	'glutamate synthase
H2677_01360	COG1704	LemA family
H2677_01365	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H2677_01375	COG4969	Belongs to the N-Me-Phe pilin family
H2677_01385	COG3307	-O-antigen
H2677_01390	COG3307	-O-antigen
H2677_01410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2677_01420	COG0194	GDP metabolic process
H2677_01425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H2677_01465	COG0228	four-way junction DNA binding
H2677_01470	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H2677_01480	COG0335	large ribosomal subunit rRNA binding
H2677_01485	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H2677_01490	COG5380	lipid catabolic process
H2677_01495	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H2677_01515	COG5006	permease, DMT superfamily
H2677_01520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H2677_01525	COG0277	FAD linked oxidase domain protein
H2677_01545	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H2677_01550	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2677_01570	COG1289	transmembrane transporter activity
H2677_01575	COG2032	superoxide dismutase activity
H2677_01580	COG0628	permease
H2677_01585	COG1192	Involved in chromosome partitioning
H2677_01595	COG2226	methyltransferase
H2677_01615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H2677_01635	COG1404	Belongs to the peptidase S8 family
H2677_01645	COG2072	flavoprotein involved in K transport
H2677_01690	COG0471	metal ion transport
H2677_01700	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H2677_01700	COG0517	IMP dehydrogenase activity
H2677_01700	COG0617	tRNA 3'-terminal CCA addition
H2677_01705	COG1983	PspC domain protein
H2677_01715	COG1960	acyl-CoA dehydrogenase activity
H2677_01730	COG0408	coproporphyrinogen oxidase activity
H2677_01750	COG0513	Belongs to the DEAD box helicase family
H2677_01760	COG1127	ABC transporter
H2677_01765	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H2677_01770	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H2677_01775	COG2854	intermembrane phospholipid transfer
H2677_01790	COG0598	Magnesium transport protein CorA
H2677_01805	COG1040	competence protein
H2677_01810	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H2677_01825	COG2937	Belongs to the GPAT DAPAT family
H2677_01830	COG1946	Acyl-CoA thioesterase
H2677_01835	COG1301	dicarboxylic acid transport
H2677_01850	COG1959	2 iron, 2 sulfur cluster binding
H2677_01860	COG0433	COG0433 Predicted ATPase
H2677_01865	COG0626	cystathionine gamma-synthase activity
H2677_01880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H2677_01900	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H2677_01925	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H2677_01950	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H2677_01965	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H2677_02030	COG1960	acyl-CoA dehydrogenase activity
H2677_02035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H2677_02070	COG0697	spore germination
H2677_02085	COG0339	signal peptide processing
H2677_02095	COG0557	exoribonuclease II activity
H2677_02130	COG0179	Fumarylacetoacetate (FAA) hydrolase
H2677_02150	COG1295	ribonuclease BN
H2677_02180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H2677_02205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2677_02205	COG2813	Specifically methylates the guanine in position
H2677_02215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2677_02225	COG4774	siderophore transport
H2677_02235	COG0740	serine-type endopeptidase activity
H2677_02255	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H2677_02255	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H2677_02270	COG0280	phosphate acetyltransferase
H2677_02270	COG0857	belongs to the CobB CobQ family
H2677_02275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H2677_02285	COG2267	carboxylic ester hydrolase activity
H2677_02300	COG0793	Belongs to the peptidase S41A family
H2677_02325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H2677_02335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2677_02340	COG1408	metallophosphoesterase
H2677_02350	COG2199	diguanylate cyclase activity
H2677_02410	COG1607	acyl-coa hydrolase
H2677_02415	COG1956	GAF domain-containing protein
H2677_02430	COG1666	GTP binding
H2677_02450	COG2350	Protein conserved in bacteria
H2677_02460	COG0613	PHP domain protein
H2677_02465	COG3781	membrane
H2677_02470	COG2003	Belongs to the UPF0758 family
H2677_02475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H2677_02510	COG1162	GTPase activity
H2677_02515	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H2677_02535	COG1538	Outer membrane efflux protein
H2677_02540	COG1136	(ABC) transporter
H2677_02540	COG0577	efflux transmembrane transporter activity
H2677_02545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2677_02555	COG1466	dna polymerase III delta subunit
H2677_02575	COG0028	Belongs to the TPP enzyme family
H2677_02580	COG0440	acetolactate synthase activity
H2677_02595	COG3243	poly(R)-hydroxyalkanoic acid synthase
H2677_02605	COG0640	Transcriptional regulator
H2677_02615	COG0798	PFAM Bile acid sodium symporter
H2677_02620	COG0431	NADPH-dependent FMN reductase
H2677_02635	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H2677_02645	COG0726	polysaccharide deacetylase
H2677_02650	COG0084	hydrolase, TatD family'
H2677_02665	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H2677_02675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H2677_02770	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H2677_02795	COG2814	Major facilitator Superfamily
H2677_02825	COG0300	oxidoreductase activity
H2677_02830	COG0004	ammonium transporteR
H2677_02845	COG3622	Belongs to the hyi family
H2677_02850	COG2084	Dehydrogenase
H2677_02855	COG1024	Enoyl-CoA hydratase
H2677_02860	COG5002	protein histidine kinase activity
H2677_02860	COG2205	protein histidine kinase activity
H2677_02860	COG0784	Response regulator, receiver
H2677_02880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2677_02890	COG3956	TIGRFAM MazG family protein
H2677_02895	COG1555	photosystem II stabilization
H2677_02900	COG0617	tRNA 3'-terminal CCA addition
H2677_02905	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H2677_02930	COG3028	Belongs to the UPF0307 family
H2677_02935	COG0318	PFAM AMP-dependent synthetase and ligase
H2677_02955	COG0625	glutathione transferase activity
H2677_02965	COG1238	metal cluster binding
H2677_03000	COG0072	phenylalanine-tRNA ligase activity
H2677_03025	COG0248	Ppx GppA phosphatase
H2677_03035	COG0037	tRNA processing
H2677_03050	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H2677_03050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H2677_03075	COG1764	response to oxidative stress
H2677_03085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2677_03145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H2677_03150	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H2677_03155	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H2677_03220	COG1968	undecaprenyl-diphosphatase activity
H2677_03245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H2677_03255	COG2132	Multicopper oxidase
H2677_03285	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H2677_03290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H2677_03340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H2677_03355	COG1063	alcohol dehydrogenase
H2677_03375	COG1309	transcriptional regulator
H2677_03380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H2677_03395	COG2814	Major facilitator Superfamily
H2677_03405	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2677_03420	COG0745	RESPONSE REGULATOR receiver
H2677_03425	COG2205	protein histidine kinase activity
H2677_03435	COG3706	GGDEF domain
H2677_03440	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2677_03450	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2677_03450	COG0649	NAD binding
H2677_03460	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H2677_03475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2677_03490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2677_03495	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2677_03515	COG1278	Cold shock
H2677_03520	COG0583	DNA-binding transcription factor activity
H2677_03525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2677_03540	COG0668	transmembrane transport
H2677_03550	COG2081	HI0933 family
H2677_03560	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H2677_03590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2677_03600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2677_03600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2677_03625	COG0489	protein tyrosine kinase activity
H2677_03655	COG0644	oxidoreductase
H2677_03690	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H2677_03710	COG0730	response to heat
H2677_03720	COG1196	nuclear chromosome segregation
H2677_03730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H2677_03745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H2677_03755	COG0596	Alpha beta hydrolase
H2677_03755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2677_03755	COG2226	methyltransferase
H2677_03770	COG4106	trans-aconitate 2-methyltransferase activity
H2677_03815	COG4166	transmembrane transport
H2677_03840	COG4172	Belongs to the ABC transporter superfamily
H2677_03850	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H2677_03855	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H2677_03865	COG0009	L-threonylcarbamoyladenylate synthase
H2677_03870	COG3101	peptidyl-lysine hydroxylation
H2677_03875	COG1399	metal-binding, possibly nucleic acid-binding protein
H2677_03880	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H2677_03900	COG1652	LysM domain
H2677_03905	COG0351	phosphomethylpyrimidine kinase
H2677_03905	COG0352	thiamine-phosphate diphosphorylase activity
H2677_03905	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H2677_03915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H2677_03950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H2677_03980	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H2677_04005	COG0564	pseudouridine synthase activity
H2677_04030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H2677_04055	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H2677_04055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2677_04070	COG1981	membrane
H2677_04090	COG0049	tRNA binding
H2677_04100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H2677_04115	COG0456	acetyltransferase
H2677_04125	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H2677_04130	COG0500	methyltransferase
H2677_04135	COG0492	ferredoxin-NADP+ reductase activity
H2677_04140	COG1674	ftsk spoiiie
H2677_04145	COG1280	lysine exporter protein (LysE YggA)
H2677_04155	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H2677_04165	COG0850	regulation of cytokinetic process
H2677_04175	COG0204	Acyl-transferase
H2677_04180	COG2885	chlorophyll binding
H2677_04185	COG0210	DNA helicase
H2677_04190	COG0756	dUTP diphosphatase activity
H2677_04195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2677_04210	COG0121	glutamine amidotransferase
H2677_04230	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H2677_04260	COG0420	3'-5' exonuclease activity
H2677_04295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2677_04310	COG1566	PFAM secretion protein HlyD family protein
H2677_04315	COG2814	Major facilitator Superfamily
H2677_04325	COG0789	Transcriptional regulator
H2677_04330	COG2217	Heavy metal translocating P-type atpase
H2677_04365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2677_04370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H2677_04380	COG1012	belongs to the aldehyde dehydrogenase family
H2677_04395	COG0833	amino acid
H2677_04400	COG3040	lipid binding
H2677_04410	COG3046	protein related to deoxyribodipyrimidine photolyase
H2677_04520	COG0725	ABC transporter, periplasmic molybdate-binding protein
H2677_04525	COG4149	molybdate abc transporter
H2677_04540	COG1230	cation diffusion facilitator family transporter
H2677_04550	COG4521	taurine ABC transporter
H2677_04555	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H2677_04560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2677_04565	COG2175	clavaminate synthase activity
H2677_04570	COG0589	response to stress
H2677_04590	COG0242	peptide deformylase activity
H2677_04615	COG0306	phosphate transporter
H2677_04630	COG1115	amino acid carrier protein
H2677_04635	COG1113	amino acid transport
H2677_04645	COG0019	diaminopimelate decarboxylase activity
H2677_04650	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H2677_04660	COG1280	lysine exporter protein (LysE YggA)
H2677_04690	COG0842	Transport permease protein
H2677_04725	COG1671	Belongs to the UPF0178 family
H2677_04740	COG4591	ABC-type transport system involved in lipoprotein release permease component
H2677_04745	COG1136	(ABC) transporter
H2677_04750	COG0658	competence protein
H2677_04750	COG2333	competence protein COMEC
H2677_04760	COG0616	signal peptide processing
H2677_04760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H2677_04770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H2677_04780	COG0628	permease
H2677_04785	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H2677_04815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2677_04835	COG0823	Involved in the tonB-independent uptake of proteins
H2677_04855	COG0824	Thioesterase
H2677_04890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H2677_04890	COG0047	phosphoribosylformylglycinamidine synthase activity
H2677_04895	COG2814	Major facilitator Superfamily
H2677_04905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H2677_04905	COG3323	Protein of unknown function (DUF1653)
H2677_04910	COG0778	Nitroreductase
H2677_04915	COG1024	Enoyl-CoA hydratase
H2677_04920	COG1051	belongs to the nudix hydrolase family
H2677_04920	COG1056	cytidyltransferase-related domain
H2677_04930	COG0625	glutathione transferase activity
H2677_04935	COG1942	4-Oxalocrotonate Tautomerase
H2677_04955	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H2677_04970	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H2677_04975	COG0602	queuosine metabolic process
H2677_04990	COG0583	DNA-binding transcription factor activity
H2677_04995	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H2677_05000	COG4208	sulfate ABC transporter
H2677_05005	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H2677_05015	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H2677_05020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2677_05025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H2677_05040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2677_05050	COG0481	GTPase activity
H2677_05065	COG0571	ribonuclease III activity
H2677_05070	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H2677_05085	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H2677_05105	COG0436	Aminotransferase
H2677_05130	COG0556	nucleotide-excision repair
H2677_05185	COG0583	DNA-binding transcription factor activity
H2677_05190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2677_05195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2677_05200	COG1773	rubredoxin
H2677_05210	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H2677_05220	COG0175	sulfate reduction
H2677_05240	COG0222	ribosome binding
H2677_05245	COG1253	flavin adenine dinucleotide binding
H2677_05260	COG3015	lipoprotein NlpE involved in copper resistance
H2677_05275	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H2677_05275	COG0517	IMP dehydrogenase activity
H2677_05280	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H2677_05290	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H2677_05295	COG1137	ATPase activity
H2677_05300	COG1538	Outer membrane efflux protein
H2677_05315	COG1739	Uncharacterized protein family UPF0029
H2677_05320	COG0110	maltose O-acetyltransferase activity
H2677_05340	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H2677_05350	COG0582	viral genome integration into host DNA
H2677_05395	COG1222	aaa ATPase
H2677_05435	COG3152	Membrane
H2677_05470	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H2677_05475	COG2826	transposase and inactivated derivatives, IS30 family
H2677_05500	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H2677_05515	COG1840	ABC-type Fe3 transport system, periplasmic component
H2677_05520	COG3842	ATPase activity
H2677_05530	COG1253	flavin adenine dinucleotide binding
H2677_05535	COG0772	Belongs to the SEDS family
H2677_05555	COG5002	protein histidine kinase activity
H2677_05570	COG2351	hydroxyisourate hydrolase activity
H2677_05585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H2677_05590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2677_05625	COG4783	chaperone-mediated protein folding
H2677_05640	COG1610	YqeY-like protein
H2677_05660	COG0697	spore germination
H2677_05680	COG2815	serine threonine protein kinase
H2677_05680	COG0515	serine threonine protein kinase
H2677_05705	COG1414	Transcriptional regulator
H2677_05725	COG1028	Short-chain dehydrogenase reductase Sdr
H2677_05740	COG2271	Major facilitator Superfamily
H2677_05755	COG1028	Short-chain dehydrogenase reductase Sdr
H2677_05770	COG0028	Belongs to the TPP enzyme family
H2677_05815	COG0482	sulfurtransferase activity
H2677_05830	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H2677_05835	COG1686	Belongs to the peptidase S11 family
H2677_05860	COG0583	DNA-binding transcription factor activity
H2677_05865	COG1067	ATP-dependent peptidase activity
H2677_05890	COG1028	Short-chain dehydrogenase reductase Sdr
H2677_05910	COG1509	lysine 2,3-aminomutase activity
H2677_05915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H2677_05920	COG1966	Carbon starvation protein
H2677_05925	COG2879	small protein
H2677_05930	COG0714	Associated with various cellular activities
H2677_06010	COG2197	response regulator
H2677_06025	COG2267	carboxylic ester hydrolase activity
H2677_06050	COG0463	Glycosyl transferase, family 2
H2677_06055	COG4585	Histidine kinase
H2677_06060	COG2197	response regulator
H2677_06095	COG1741	Belongs to the pirin family
H2677_06105	COG1902	pentaerythritol trinitrate reductase activity
H2677_06105	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2677_06115	COG2207	Transcriptional regulator
H2677_06130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2677_06135	COG0183	Belongs to the thiolase family
H2677_06140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H2677_06145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H2677_06155	COG4829	muconolactone delta-isomerase
H2677_06160	COG4948	Mandelate Racemase Muconate Lactonizing
H2677_06165	COG0543	2 iron, 2 sulfur cluster binding
H2677_06165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2677_06170	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H2677_06175	COG4638	Rieske (2fe-2S)
H2677_06205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H2677_06210	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H2677_06210	COG4451	ribulose bisphosphate carboxylase, small
H2677_06215	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H2677_06220	COG1469	GTP cyclohydrolase I activity
H2677_06235	COG0523	cobalamin synthesis protein
H2677_06240	COG1960	acyl-CoA dehydrogenase activity
H2677_06280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H2677_06290	COG4106	trans-aconitate 2-methyltransferase activity
H2677_06295	COG0642	Histidine kinase
H2677_06300	COG0745	RESPONSE REGULATOR receiver
H2677_06325	COG2985	domain, Protein
H2677_06385	COG2351	hydroxyisourate hydrolase activity
H2677_06390	COG2233	PERMEase
H2677_06400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2677_06430	COG0583	DNA-binding transcription factor activity
H2677_06440	COG2188	Transcriptional regulator
H2677_06470	COG0010	Belongs to the arginase family
H2677_06475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2677_06480	COG1028	Short-chain dehydrogenase reductase Sdr
H2677_06495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2677_06525	COG0243	molybdopterin cofactor binding
H2677_06530	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H2677_06535	COG1309	transcriptional regulator
H2677_06555	COG2072	flavoprotein involved in K transport
H2677_06560	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H2677_06565	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H2677_06570	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H2677_06575	COG4770	biotin carboxylase activity
H2677_06580	COG0501	Belongs to the peptidase M48B family
H2677_06590	COG1765	OsmC-like protein
H2677_06640	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H2677_06680	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2677_06700	COG1643	Atp-dependent helicase
H2677_06715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H2677_06720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2677_06740	COG2951	lytic endotransglycosylase activity
H2677_06745	COG0772	Belongs to the SEDS family
H2677_06760	COG0842	Transport permease protein
H2677_06765	COG1131	(ABC) transporter
H2677_06770	COG0583	DNA-binding transcription factor activity
H2677_06780	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H2677_06790	COG3659	wide pore channel activity
H2677_06845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H2677_06850	COG0826	peptidase U32
H2677_06860	COG4682	membrane
H2677_06875	COG2808	Putative FMN-binding domain
H2677_06890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H2677_06895	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2677_06905	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H2677_06930	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H2677_06960	COG0729	surface antigen
H2677_06990	COG0471	metal ion transport
H2677_06995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H2677_07005	COG3647	Membrane
H2677_07010	COG2814	Major facilitator Superfamily
H2677_07015	COG0583	DNA-binding transcription factor activity
H2677_07040	COG1720	tRNA m6t6A37 methyltransferase activity
H2677_07050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H2677_07065	COG0642	Histidine kinase
H2677_07075	COG0494	nUDIX hydrolase
H2677_07085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2677_07090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H2677_07095	COG3139	Protein of unknown function (DUF1315)
H2677_07120	COG1960	acyl-CoA dehydrogenase activity
H2677_07135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H2677_07145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H2677_07150	COG2195	Cleaves the N-terminal amino acid of tripeptides
H2677_07170	COG1690	Belongs to the RtcB family
H2677_07175	COG1234	tRNA 3'-trailer cleavage
H2677_07180	COG4650	regulator
H2677_07245	COG0513	Belongs to the DEAD box helicase family
H2677_07255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2677_07265	COG3178	'Phosphotransferase
H2677_07270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H2677_07280	COG1192	Involved in chromosome partitioning
H2677_07285	COG1475	DNA binding
H2677_07290	COG0811	peptide transport
H2677_07300	COG1132	(ABC) transporter
H2677_07305	COG1663	tetraacyldisaccharide 4'-kinase activity
H2677_07325	COG0084	hydrolase, TatD family'
H2677_07390	COG0776	regulation of translation
H2677_07425	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H2677_07430	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H2677_07465	COG0024	Methionine aminopeptidase
H2677_07470	COG0583	DNA-binding transcription factor activity
H2677_07475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2677_07485	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H2677_07490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H2677_07495	COG0517	IMP dehydrogenase activity
H2677_07495	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H2677_07520	COG0552	protein localization to endoplasmic reticulum
H2677_07530	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H2677_07545	COG4890	Cyd operon protein YbgT
H2677_07550	COG1294	oxidase, subunit
H2677_07575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2677_07595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H2677_07600	COG0569	domain protein
H2677_07605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H2677_07610	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H2677_07635	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H2677_07640	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H2677_07645	COG0542	response to heat
H2677_07655	COG0488	(ABC) transporter
H2677_07660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H2677_07665	COG2267	carboxylic ester hydrolase activity
H2677_07675	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2677_07675	COG1902	pentaerythritol trinitrate reductase activity
H2677_07715	COG0148	phosphopyruvate hydratase activity
H2677_07720	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H2677_07760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2677_07765	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H2677_07780	COG1802	Transcriptional regulator
H2677_07785	COG2207	Transcriptional regulator
H2677_07790	COG1063	alcohol dehydrogenase
H2677_07800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H2677_07820	COG1454	alcohol dehydrogenase
H2677_07830	COG2814	Major facilitator Superfamily
H2677_07835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2677_07840	COG0183	Belongs to the thiolase family
H2677_07845	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H2677_07850	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H2677_07855	COG3135	benzoate transporter
H2677_07860	COG1028	Short-chain dehydrogenase reductase Sdr
H2677_07865	COG0633	Ferredoxin
H2677_07865	COG0543	2 iron, 2 sulfur cluster binding
H2677_07870	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H2677_07875	COG4638	Rieske (2fe-2S)
H2677_07885	COG4829	muconolactone delta-isomerase
H2677_07890	COG4948	Mandelate Racemase Muconate Lactonizing
H2677_07895	COG0583	DNA-binding transcription factor activity
H2677_07900	COG3618	amidohydrolase
H2677_07905	COG1944	ATP diphosphatase activity
H2677_07915	COG4221	oxidoreductase activity
H2677_07930	COG0439	Biotin carboxylase
H2677_07935	COG0864	Transcriptional regulator
H2677_07940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2677_07950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2677_07970	COG0583	DNA-binding transcription factor activity
H2677_07980	COG4770	biotin carboxylase activity
H2677_07985	COG1024	Enoyl-CoA hydratase
H2677_07990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H2677_07995	COG1960	acyl-CoA dehydrogenase activity
H2677_08000	COG1309	transcriptional regulator
H2677_08005	COG0318	PFAM AMP-dependent synthetase and ligase
H2677_08020	COG2814	Major facilitator Superfamily
H2677_08025	COG0183	Belongs to the thiolase family
H2677_08040	COG0583	DNA-binding transcription factor activity
H2677_08065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2677_08070	COG0730	response to heat
H2677_08090	COG4628	conserved protein (DUF2132)
H2677_08110	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2677_08120	COG3706	GGDEF domain
H2677_08135	COG0133	tryptophan synthase activity
H2677_08145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2677_08165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H2677_08195	COG0537	adenosine 5'-monophosphoramidase activity
H2677_08220	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2677_08230	COG0730	response to heat
H2677_08250	COG4771	TonB-dependent receptor
H2677_08265	COG0406	alpha-ribazole phosphatase activity
H2677_08270	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H2677_08285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2677_08300	COG2814	Major facilitator Superfamily
H2677_08330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H2677_08345	COG1960	acyl-CoA dehydrogenase activity
H2677_08350	COG1960	acyl-CoA dehydrogenase activity
H2677_08355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2677_08360	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2677_08365	COG2207	Transcriptional regulator
H2677_08370	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2677_08405	COG0575	Belongs to the CDS family
H2677_08410	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H2677_08415	COG0233	cytoplasmic translational termination
H2677_08430	COG3852	Histidine kinase
H2677_08435	COG2204	response regulator
H2677_08505	COG0697	spore germination
H2677_08510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2677_08520	COG0303	'Molybdopterin
H2677_08525	COG0315	cyclic pyranopterin monophosphate synthase activity
H2677_08525	COG0521	Mo-molybdopterin cofactor biosynthetic process
H2677_08540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H2677_08545	COG0243	molybdopterin cofactor binding
H2677_08560	COG0243	molybdopterin cofactor binding
H2677_08565	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2677_08570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2677_08575	COG2223	nitrite transmembrane transporter activity
H2677_08585	COG1116	anion transmembrane transporter activity
H2677_08585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2677_08615	COG2814	Major facilitator Superfamily
H2677_08620	COG1113	amino acid transport
H2677_08630	COG0625	glutathione transferase activity
H2677_08650	COG0069	glutamate synthase activity
H2677_08685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H2677_08690	COG1454	alcohol dehydrogenase
H2677_08695	COG0824	Thioesterase
H2677_08700	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H2677_08705	COG2850	peptidyl-arginine hydroxylation
H2677_08750	COG3122	Protein conserved in bacteria
H2677_08755	COG0668	transmembrane transport
H2677_08770	COG1132	(ABC) transporter
H2677_08790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2677_08800	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H2677_08800	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H2677_08800	COG0506	proline dehydrogenase activity
H2677_08805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H2677_08815	COG3698	Phosphodiester glycosidase
H2677_08825	COG0590	tRNA wobble adenosine to inosine editing
H2677_08830	COG3811	Belongs to the UPF0386 family
H2677_08840	COG2353	YceI-like domain
H2677_08850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H2677_08855	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H2677_08885	COG1278	Cold shock
H2677_08905	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H2677_08905	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H2677_08930	COG3539	Fimbrial protein
H2677_08960	COG0582	viral genome integration into host DNA
H2677_08990	COG0582	viral genome integration into host DNA
H2677_09020	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H2677_09030	COG1674	ftsk spoiiie
H2677_09140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H2677_09145	COG0753	catalase activity
H2677_09150	COG1560	Kdo2-lipid A biosynthetic process
H2677_09205	COG1464	Belongs to the NlpA lipoprotein family
H2677_09210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H2677_09215	COG2011	ABC-type metal ion transport system permease component
H2677_09220	COG0012	GTP binding
H2677_09235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H2677_09280	COG0386	Belongs to the glutathione peroxidase family
H2677_09290	COG0436	Aminotransferase
H2677_09325	COG2267	carboxylic ester hydrolase activity
H2677_09330	COG3634	alkyl hydroperoxide reductase activity
H2677_09380	COG1286	toxin biosynthetic process
H2677_09410	COG0778	Nitroreductase
H2677_09435	COG0424	maF-like protein
H2677_09470	COG2030	dehydratase
H2677_09480	COG0183	Belongs to the thiolase family
H2677_09495	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H2677_09500	COG0702	epimerase
H2677_09505	COG0268	Binds directly to 16S ribosomal RNA
H2677_09525	COG1011	Hydrolase
H2677_09530	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H2677_09540	COG2137	regulation of response to DNA damage stimulus
H2677_09555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2677_09585	COG0822	iron-sulfur transferase activity
H2677_09590	COG0316	Belongs to the HesB IscA family
H2677_09620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H2677_09645	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H2677_09655	COG3135	benzoate transporter
H2677_09660	COG0475	glutathione-regulated potassium exporter activity
H2677_09660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2677_09675	COG1760	l-serine dehydratase
H2677_09680	COG0308	aminopeptidase N
H2677_09715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2677_09725	COG0531	amino acid
H2677_09730	COG4303	Ethanolamine ammonia lyase large subunit
H2677_09735	COG4302	ethanolamine ammonia-lyase activity
H2677_09745	COG0519	Catalyzes the synthesis of GMP from XMP
H2677_09745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2677_09750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2677_09760	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2677_09765	COG0778	Nitroreductase
H2677_09770	COG0697	spore germination
H2677_09775	COG1923	regulation of RNA biosynthetic process
H2677_09785	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H2677_09790	COG0802	atpase or kinase
H2677_09825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2677_09850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H2677_09855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2677_09860	COG1845	cytochrome c oxidase, subunit III
H2677_09865	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H2677_09900	COG0305	Participates in initiation and elongation during chromosome replication
H2677_09905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H2677_09915	COG1305	Transglutaminase-like
H2677_09925	COG2308	Evidence 4 Homologs of previously reported genes of
H2677_09935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H2677_09950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H2677_09975	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H2677_09980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2677_10020	COG2755	lipolytic protein G-D-S-L family
H2677_10020	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H2677_10105	COG3566	protein conserved in bacteria
H2677_10115	COG2369	cell adhesion
H2677_10120	COG3567	Phage-associated protein, HI1409 family
H2677_10125	COG5410	chromosome segregation
H2677_10160	COG1484	DNA-dependent DNA replication
H2677_10180	COG3620	sequence-specific DNA binding
H2677_10230	COG0527	aspartate kinase activity
H2677_10240	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H2677_10255	COG3038	cytochrome b561
H2677_10260	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H2677_10265	COG2252	PERMEase
H2677_10320	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H2677_10325	COG0138	bifunctional purine biosynthesis protein purh
H2677_10330	COG0151	Belongs to the GarS family
H2677_10340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H2677_10345	COG2011	ABC-type metal ion transport system permease component
H2677_10370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H2677_10380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H2677_10390	COG0280	phosphate acetyltransferase
H2677_10390	COG0281	malic enzyme
H2677_10405	COG0052	Belongs to the universal ribosomal protein uS2 family
H2677_10410	COG0024	Methionine aminopeptidase
H2677_10420	COG2223	nitrite transmembrane transporter activity
H2677_10430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2677_10435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H2677_10440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H2677_10475	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H2677_10480	COG3161	chorismate lyase activity
H2677_10485	COG0174	glutamine synthetase
H2677_10490	COG0512	Glutamine amidotransferase of anthranilate synthase
H2677_10495	COG1823	symporter activity
H2677_10500	COG0633	Ferredoxin
H2677_10500	COG3217	Mosc domain protein beta barrel domain protein
H2677_10525	COG0302	gtp cyclohydrolase
H2677_10545	COG3739	integral membrane protein
H2677_10560	COG5001	Diguanylate cyclase
H2677_10560	COG4251	negative regulation of phosphorylation
H2677_10560	COG2203	Gaf domain
H2677_10560	COG3706	GGDEF domain
H2677_10570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H2677_10590	COG4172	Belongs to the ABC transporter superfamily
H2677_10595	COG4239	(ABC) transporter, permease
H2677_10600	COG4174	ABC transporter (Permease)
H2677_10605	COG4166	transmembrane transport
H2677_10610	COG0741	lytic transglycosylase activity
H2677_10610	COG1388	LysM domain
H2677_10615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H2677_10670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2677_10675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2677_10680	COG0006	proline dipeptidase activity
H2677_10715	COG3552	Protein containing von Willebrand factor type A (VWA) domain
H2677_10725	COG0714	Associated with various cellular activities
H2677_10730	COG3831	ATPase activity
H2677_10745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H2677_10760	COG3384	dioxygenase
H2677_10770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2677_10775	COG2878	Part of a membrane complex involved in electron transport
H2677_10780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H2677_10805	COG0768	penicillin binding
H2677_10810	COG0742	ribosomal rna small subunit methyltransferase
H2677_10835	COG0616	signal peptide processing
H2677_10840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H2677_10850	COG0573	inorganic phosphate transmembrane transporter activity
H2677_10865	COG0076	glutamate decarboxylase activity
H2677_10870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H2677_10880	COG1309	transcriptional regulator
H2677_10900	COG1309	transcriptional regulator
H2677_10910	COG0783	Belongs to the Dps family
H2677_10920	COG0564	pseudouridine synthase activity
H2677_10930	COG0352	thiamine-phosphate diphosphorylase activity
H2677_10940	COG3025	triphosphatase activity
H2677_10960	COG0612	Peptidase, M16
H2677_10975	COG1187	pseudouridine synthase activity
H2677_10995	COG1686	Belongs to the peptidase S11 family
H2677_11000	COG1252	NADH dehydrogenase
H2677_11010	COG0415	Belongs to the DNA photolyase family
H2677_11025	COG1215	transferase activity, transferring glycosyl groups
H2677_11060	COG1271	oxidase subunit
H2677_11065	COG1294	oxidase, subunit
H2677_11070	COG2070	2-Nitropropane dioxygenase
H2677_11085	COG0457	Tetratricopeptide repeat
H2677_11085	COG0705	Rhomboid family
H2677_11090	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H2677_11095	COG4181	ATPase activity
H2677_11115	COG0288	reversible hydration of carbon dioxide
H2677_11130	COG4771	TonB-dependent receptor
H2677_11155	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H2677_11195	COG1597	lipid kinase activity
H2677_11200	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H2677_11215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H2677_11225	COG2388	GCN5-related N-acetyl-transferase
H2677_11265	COG1215	transferase activity, transferring glycosyl groups
H2677_11270	COG1649	PFAM Uncharacterised BCR, COG1649
H2677_11270	COG0726	polysaccharide deacetylase
H2677_11285	COG4681	YaeQ
H2677_11290	COG0523	cobalamin synthesis protein
H2677_11300	COG1607	acyl-coa hydrolase
H2677_11315	COG0583	DNA-binding transcription factor activity
H2677_11320	COG1301	dicarboxylic acid transport
H2677_11325	COG0582	viral genome integration into host DNA
H2677_11370	COG1785	Belongs to the alkaline phosphatase family
H2677_11375	COG1785	Belongs to the alkaline phosphatase family
H2677_11410	COG0732	type I restriction modification DNA specificity domain
H2677_11415	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H2677_11425	COG2184	nucleotidyltransferase activity
H2677_11495	COG3311	Transcriptional regulator
H2677_11515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H2677_11520	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H2677_11535	COG0741	lytic transglycosylase activity
H2677_11540	COG0501	Belongs to the peptidase M48B family
H2677_11550	COG2239	Acts as a magnesium transporter
H2677_11560	COG2194	sulfuric ester hydrolase activity
H2677_11565	COG0584	glycerophosphoryl diester phosphodiesterase
H2677_11570	COG3201	nicotinamide mononucleotide transporter
H2677_11590	COG2304	oxidoreductase activity
H2677_11595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H2677_11600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2677_11625	COG0505	Belongs to the CarA family
H2677_11645	COG0589	response to stress
H2677_11690	COG2321	neutral zinc metallopeptidase
H2677_11695	COG2354	Protein conserved in bacteria
H2677_11705	COG1585	Membrane protein implicated in regulation of membrane protease activity
H2677_11710	COG2268	Band 7 protein
H2677_11725	COG0726	polysaccharide deacetylase
H2677_11725	COG1649	PFAM Uncharacterised BCR, COG1649
H2677_11745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2677_11760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H2677_11765	COG1053	succinate dehydrogenase
H2677_11770	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H2677_11775	COG2009	succinate dehydrogenase
H2677_11800	COG1054	Belongs to the UPF0176 family
H2677_11810	COG0586	Pfam SNARE associated Golgi protein
H2677_11815	COG0500	methyltransferase
H2677_11825	COG0583	DNA-binding transcription factor activity
H2677_11860	COG0321	lipoyl(octanoyl) transferase activity
H2677_11875	COG0531	amino acid
H2677_11885	COG1733	regulation of RNA biosynthetic process
H2677_11890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H2677_11895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H2677_11895	COG1648	precorrin-2 dehydrogenase activity
H2677_11910	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H2677_11940	COG0671	phosphoesterase, PA-phosphatase related
H2677_11945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2677_11955	COG1538	Outer membrane efflux protein
H2677_11960	COG0393	Putative heavy-metal-binding
H2677_11965	COG0393	Putative heavy-metal-binding
H2677_11975	COG1028	Short-chain dehydrogenase reductase Sdr
H2677_11990	COG0525	valine-tRNA ligase activity
H2677_12010	COG0004	ammonium transporteR
H2677_12025	COG0642	Histidine kinase
H2677_12030	COG0745	RESPONSE REGULATOR receiver
H2677_12035	COG2194	sulfuric ester hydrolase activity
H2677_12055	COG1752	Esterase of the alpha-beta hydrolase superfamily
H2677_12070	COG2814	Major facilitator Superfamily
H2677_12075	COG0142	geranyltranstransferase activity
H2677_12085	COG1113	amino acid transport
H2677_12100	COG0174	glutamine synthetase
H2677_12105	COG0671	phosphoesterase, PA-phosphatase related
H2677_12115	COG2851	Citrate transporter
H2677_12125	COG0745	RESPONSE REGULATOR receiver
H2677_12130	COG2205	protein histidine kinase activity
H2677_12135	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H2677_12140	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H2677_12145	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H2677_12170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2677_12180	COG1530	ribonuclease E activity
H2677_12185	COG0424	maF-like protein
H2677_12195	COG1792	Involved in formation and maintenance of cell shape
H2677_12200	COG1077	Cell shape determining protein MreB Mrl
H2677_12205	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2677_12215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2677_12270	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H2677_12275	COG1752	Esterase of the alpha-beta hydrolase superfamily
H2677_12280	COG1115	amino acid carrier protein
H2677_12285	COG0786	glutamate:sodium symporter activity
H2677_12300	COG2814	Major facilitator Superfamily
H2677_12305	COG1289	transmembrane transporter activity
H2677_12315	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H2677_12360	COG1376	ErfK ybiS ycfS ynhG family protein
H2677_12365	COG2832	Protein of unknown function (DUF454)
H2677_12375	COG5510	response to toxic substance
H2677_12390	COG0643	Histidine kinase
H2677_12390	COG2198	Histidine kinase
H2677_12390	COG0643	Histidine kinase
H2677_12390	COG2198	Histidine kinase
H2677_12395	COG0840	transmembrane signaling receptor activity
H2677_12425	COG3422	double-strand break repair
H2677_12430	COG2824	Alkylphosphonate utilization operon protein PhnA
H2677_12435	COG3189	MarR family transcriptional regulator
H2677_12445	COG0354	folic acid binding
H2677_12455	COG4772	TonB-dependent receptor
H2677_12465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2677_12475	COG1970	mechanosensitive ion channel activity
H2677_12480	COG1217	gtp-binding protein TYPA
H2677_12485	COG2233	PERMEase
H2677_12495	COG0833	amino acid
H2677_12500	COG1690	Belongs to the RtcB family
H2677_12510	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H2677_12510	COG2885	chlorophyll binding
H2677_12520	COG0183	Belongs to the thiolase family
H2677_12540	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2677_12555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H2677_12560	COG2207	Transcriptional regulator
H2677_12575	COG0183	Belongs to the thiolase family
H2677_12610	COG1272	protein, Hemolysin III
H2677_12615	COG0477	Major facilitator Superfamily
H2677_12635	COG0450	alkyl hydroperoxide reductase
H2677_12660	COG0285	dihydrofolate synthase activity
H2677_12720	COG4206	TonB-dependent receptor
H2677_12725	COG2096	Adenosyltransferase
H2677_12745	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H2677_12760	COG0745	RESPONSE REGULATOR receiver
H2677_12765	COG2205	protein histidine kinase activity
H2677_12775	COG1960	acyl-CoA dehydrogenase activity
H2677_12780	COG1960	acyl-CoA dehydrogenase activity
H2677_12845	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H2677_12860	COG3306	glycosyltransferase involved in LPS biosynthesis
H2677_12890	COG0438	transferase activity, transferring glycosyl groups
H2677_12910	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H2677_12915	COG2205	protein histidine kinase activity
H2677_12915	COG0784	Response regulator, receiver
H2677_12930	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H2677_12950	COG1862	Preprotein translocase
H2677_13030	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H2677_13035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H2677_13040	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H2677_13055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H2677_13065	COG0625	glutathione transferase activity
H2677_13070	COG2969	positive regulation of protein catabolic process
H2677_13125	COG1960	acyl-CoA dehydrogenase activity
H2677_13130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H2677_13145	COG1309	transcriptional regulator
H2677_13155	COG1960	acyl-CoA dehydrogenase activity
H2677_13160	COG1960	acyl-CoA dehydrogenase activity
H2677_13205	COG1183	phosphatidylcholine synthase activity
H2677_13210	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H2677_13240	COG0741	lytic transglycosylase activity
H2677_13240	COG1196	nuclear chromosome segregation
H2677_13240	COG0739	heme binding
H2677_13250	COG1702	phosphate starvation-inducible protein PhoH
H2677_13265	COG4773	Receptor
H2677_13330	COG0788	formyltetrahydrofolate deformylase activity
H2677_13355	COG4651	solute:proton antiporter activity
H2677_13355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2677_13380	COG0210	DNA helicase
H2677_13405	COG2900	Belongs to the SlyX family
H2677_13410	COG0488	(ABC) transporter
H2677_13420	COG1560	Kdo2-lipid A biosynthetic process
H2677_13495	COG0473	3-isopropylmalate dehydrogenase activity
H2677_13520	COG0583	DNA-binding transcription factor activity
H2677_13545	COG0494	nUDIX hydrolase
H2677_13565	COG3011	Protein conserved in bacteria
H2677_13580	COG0583	DNA-binding transcription factor activity
H2677_13605	COG1530	ribonuclease E activity
H2677_13610	COG0318	PFAM AMP-dependent synthetase and ligase
H2677_13630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H2677_13640	COG0534	Mate efflux family protein
H2677_13645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H2677_13675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2677_13690	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H2677_13690	COG0493	'glutamate synthase
H2677_13700	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H2677_13705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2677_13720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H2677_13730	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H2677_13730	COG0644	oxidoreductase
H2677_13740	COG1595	DNA-templated transcription, initiation
H2677_13750	COG3220	belongs to the UPF0276 family
H2677_13765	COG1279	arginine transmembrane transporter activity
H2677_13770	COG0425	Belongs to the sulfur carrier protein TusA family
H2677_13775	COG4535	Mg2 and Co2 transporter CorC
H2677_13800	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H2677_13810	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H2677_13815	COG0484	heat shock protein binding
H2677_13820	COG0789	Transcriptional regulator
H2677_13825	COG0598	Magnesium transport protein CorA
H2677_13830	COG1185	polyribonucleotide nucleotidyltransferase activity
H2677_13835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H2677_13840	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H2677_13845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2677_13850	COG1074	ATP-dependent DNA helicase activity
H2677_13855	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H2677_13875	COG2226	methyltransferase
H2677_13885	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H2677_13895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2677_13905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H2677_13920	COG2111	Na H antiporter
H2677_13920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2677_13925	COG1006	Multisubunit Na H antiporter MnhC subunit
H2677_13930	COG0651	ATP synthesis coupled electron transport
H2677_13935	COG1863	multisubunit Na H antiporter MnhE subunit
H2677_13940	COG2212	antiporter activity
H2677_13945	COG1320	monovalent cation:proton antiporter activity
H2677_13950	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H2677_13960	COG0195	Participates in both transcription termination and antitermination
H2677_14010	COG0237	dephospho-CoA kinase activity
H2677_14020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2677_14030	COG0497	DNA recombination
H2677_14040	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H2677_14065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H2677_14095	COG3706	GGDEF domain
H2677_14130	COG1132	(ABC) transporter
H2677_14140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H2677_14160	COG0326	Molecular chaperone. Has ATPase activity
H2677_14175	COG2056	Na+-H+ antiporter family
H2677_14220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H2677_14240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H2677_14270	COG0546	phosphoglycolate phosphatase activity
H2677_14275	COG1716	ATPase activity
H2677_14320	COG0181	hydroxymethylbilane synthase activity
H2677_14330	COG3275	phosphorelay sensor kinase activity
H2677_14370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H2677_14375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2677_14380	COG0772	Belongs to the SEDS family
H2677_14405	COG4974	Belongs to the 'phage' integrase family
H2677_14410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H2677_14420	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H2677_14440	COG2197	response regulator
H2677_14455	COG0793	Belongs to the peptidase S41A family
H2677_14460	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H2677_14465	COG0795	lipopolysaccharide-transporting ATPase activity
H2677_14470	COG0795	lipopolysaccharide-transporting ATPase activity
H2677_14505	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2677_14505	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2677_14515	COG0004	ammonium transporteR
H2677_14520	COG0347	Belongs to the P(II) protein family
H2677_14550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H2677_14565	COG0318	PFAM AMP-dependent synthetase and ligase
H2677_14575	COG2860	membrane
H2677_14585	COG1253	flavin adenine dinucleotide binding
H2677_14600	COG2814	Major facilitator Superfamily
H2677_14615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2677_14620	COG0745	RESPONSE REGULATOR receiver
H2677_14630	COG2205	protein histidine kinase activity
H2677_14635	COG4452	Inner membrane protein CreD
H2677_14660	COG2814	Major facilitator Superfamily
H2677_14680	COG0655	NAD(P)H dehydrogenase (quinone) activity
H2677_14700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H2677_14735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H2677_14755	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2677_14760	COG3162	membrane
H2677_14765	COG0784	Response regulator, receiver
H2677_14765	COG2205	protein histidine kinase activity
H2677_14790	COG1652	LysM domain
H2677_14795	COG0758	DNA mediated transformation
H2677_14810	COG1309	transcriptional regulator
H2677_14825	COG0386	Belongs to the glutathione peroxidase family
H2677_14840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H2677_14880	COG0803	Belongs to the bacterial solute-binding protein 9 family
H2677_14890	COG1121	(ABC) transporter
H2677_14895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H2677_14905	COG2837	iron assimilation
H2677_14910	COG0281	malic enzyme
H2677_14940	COG0519	Catalyzes the synthesis of GMP from XMP
H2677_14940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2677_14945	COG4399	Belongs to the UPF0754 family
H2677_14955	COG2259	Doxx family
H2677_14960	COG0586	Pfam SNARE associated Golgi protein
H2677_14975	COG1192	Involved in chromosome partitioning
H2677_14985	COG0271	Belongs to the BolA IbaG family
H2677_15020	COG3756	Protein conserved in bacteria
H2677_15035	COG0494	nUDIX hydrolase
H2677_15090	COG0477	Major facilitator Superfamily
H2677_15095	COG1024	Enoyl-CoA hydratase
H2677_15100	COG1024	Enoyl-CoA hydratase
H2677_15105	COG1960	acyl-CoA dehydrogenase activity
H2677_15110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2677_15130	COG1113	amino acid transport
H2677_15135	COG0251	oxidation-reduction process
H2677_15170	COG0564	pseudouridine synthase activity
H2677_15215	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H2677_15230	COG1802	Transcriptional regulator
H2677_15235	COG1448	Aminotransferase
H2677_15240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2677_15255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H2677_15265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H2677_15275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H2677_15285	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H2677_15290	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H2677_15335	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H2677_15360	COG0545	Peptidyl-prolyl cis-trans isomerase
H2677_15365	COG0728	peptidoglycan biosynthetic process
H2677_15370	COG3023	N-Acetylmuramoyl-L-alanine amidase
H2677_15390	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H2677_15425	COG0546	phosphoglycolate phosphatase activity
H2677_15430	COG1028	Short-chain dehydrogenase reductase Sdr
H2677_15440	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H2677_15440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H2677_15445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2677_15450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2677_15455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2677_15460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2677_15465	COG1116	anion transmembrane transporter activity
H2677_15470	COG1309	transcriptional regulator
H2677_15485	COG0196	riboflavin kinase activity
H2677_15490	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H2677_15500	COG1047	Peptidyl-prolyl cis-trans
H2677_15505	COG0431	NADPH-dependent FMN reductase
H2677_15535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H2677_15540	COG0657	acetylesterase activity
H2677_15565	COG0443	Heat shock 70 kDa protein
H2677_15570	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H2677_15595	COG2951	lytic endotransglycosylase activity
H2677_15600	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H2677_15620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H2677_15645	COG0583	DNA-binding transcription factor activity
H2677_15655	COG0861	Integral membrane protein TerC family
H2677_15665	COG0754	glutathionylspermidine amidase activity
H2677_15675	COG0402	S-adenosylhomocysteine deaminase activity
H2677_15705	COG0706	membrane insertase activity
H2677_15780	COG0488	(ABC) transporter
H2677_15800	COG1192	Involved in chromosome partitioning
H2677_15860	COG1196	nuclear chromosome segregation
H2677_15860	COG0741	lytic transglycosylase activity
H2677_15860	COG0739	heme binding
H2677_15875	COG0741	lytic transglycosylase activity
H2677_15875	COG0739	heme binding
H2677_15875	COG1196	nuclear chromosome segregation
H2677_15900	COG1525	nuclease
H2677_15920	COG0673	inositol 2-dehydrogenase activity
H2677_15940	COG2826	transposase and inactivated derivatives, IS30 family
H2677_15970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD