locus-tag	class	description
H0S56_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H0S56_00010	COG0592	DNA-directed DNA polymerase activity
H0S56_00020	COG0187	DNA topoisomerase II activity
H0S56_00025	COG1063	alcohol dehydrogenase
H0S56_00030	COG0488	(ABC) transporter
H0S56_00085	COG0657	acetylesterase activity
H0S56_00095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0S56_00125	COG2814	Major facilitator Superfamily
H0S56_00130	COG2814	Major facilitator Superfamily
H0S56_00140	COG0666	response to abiotic stimulus
H0S56_00145	COG0693	protein deglycase activity
H0S56_00155	COG1012	belongs to the aldehyde dehydrogenase family
H0S56_00160	COG0733	neurotransmitter:sodium symporter activity
H0S56_00170	COG0428	transporter
H0S56_00175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H0S56_00190	COG0129	dihydroxy-acid dehydratase activity
H0S56_00205	COG2233	PERMEase
H0S56_00215	COG1309	transcriptional regulator
H0S56_00255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H0S56_00265	COG1064	alcohol dehydrogenase
H0S56_00270	COG2818	Glycosylase
H0S56_00280	COG0739	heme binding
H0S56_00285	COG1194	a g-specific adenine glycosylase
H0S56_00320	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H0S56_00325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0S56_00345	COG0438	transferase activity, transferring glycosyl groups
H0S56_00350	COG0438	transferase activity, transferring glycosyl groups
H0S56_00355	COG0438	transferase activity, transferring glycosyl groups
H0S56_00365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0S56_00375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0S56_00390	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H0S56_00405	COG2030	dehydratase
H0S56_00425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H0S56_00450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0S56_00455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H0S56_00470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S56_00480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0S56_00485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0S56_00495	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H0S56_00500	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0S56_00510	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H0S56_00530	COG0281	malic enzyme
H0S56_00585	COG1538	Outer membrane efflux protein
H0S56_00655	COG3756	Protein conserved in bacteria
H0S56_00690	COG0271	Belongs to the BolA IbaG family
H0S56_00700	COG1192	Involved in chromosome partitioning
H0S56_00715	COG0586	Pfam SNARE associated Golgi protein
H0S56_00720	COG0519	Catalyzes the synthesis of GMP from XMP
H0S56_00720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0S56_00725	COG3706	GGDEF domain
H0S56_00730	COG3706	GGDEF domain
H0S56_00765	COG0534	Mate efflux family protein
H0S56_00770	COG0436	Aminotransferase
H0S56_00790	COG2837	iron assimilation
H0S56_00800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0S56_00805	COG1121	(ABC) transporter
H0S56_00855	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H0S56_00870	COG1012	belongs to the aldehyde dehydrogenase family
H0S56_00885	COG0386	Belongs to the glutathione peroxidase family
H0S56_00890	COG0697	spore germination
H0S56_00900	COG0758	DNA mediated transformation
H0S56_00950	COG2814	Major facilitator Superfamily
H0S56_00970	COG0477	Major facilitator Superfamily
H0S56_00975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0S56_01010	COG1253	flavin adenine dinucleotide binding
H0S56_01020	COG2860	membrane
H0S56_01025	COG0477	Major facilitator Superfamily
H0S56_01035	COG0318	PFAM AMP-dependent synthetase and ligase
H0S56_01050	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H0S56_01065	COG0606	chelatase, subunit chli
H0S56_01075	COG0347	Belongs to the P(II) protein family
H0S56_01080	COG0004	ammonium transporteR
H0S56_01090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0S56_01090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0S56_01105	COG0586	Pfam SNARE associated Golgi protein
H0S56_01125	COG0795	lipopolysaccharide-transporting ATPase activity
H0S56_01130	COG0795	lipopolysaccharide-transporting ATPase activity
H0S56_01135	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0S56_01140	COG3409	Peptidoglycan-binding domain 1 protein
H0S56_01140	COG0793	Belongs to the peptidase S41A family
H0S56_01150	COG4191	Histidine kinase
H0S56_01155	COG2197	response regulator
H0S56_01160	COG1686	Belongs to the peptidase S11 family
H0S56_01165	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0S56_01175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S56_01180	COG4974	Belongs to the 'phage' integrase family
H0S56_01205	COG0772	Belongs to the SEDS family
H0S56_01215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S56_01220	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H0S56_01225	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0S56_01230	COG0494	nUDIX hydrolase
H0S56_01245	COG1538	Outer membrane efflux protein
H0S56_01255	COG1132	(ABC) transporter
H0S56_01265	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0S56_01295	COG0497	DNA recombination
H0S56_01300	COG3123	guanosine phosphorylase activity
H0S56_01305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S56_01315	COG0237	dephospho-CoA kinase activity
H0S56_01370	COG0779	Required for maturation of 30S ribosomal subunits
H0S56_01375	COG0195	Participates in both transcription termination and antitermination
H0S56_01385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H0S56_01390	COG1320	monovalent cation:proton antiporter activity
H0S56_01395	COG2212	antiporter activity
H0S56_01400	COG1863	multisubunit Na H antiporter MnhE subunit
H0S56_01405	COG0651	ATP synthesis coupled electron transport
H0S56_01410	COG1006	Multisubunit Na H antiporter MnhC subunit
H0S56_01415	COG2111	Na H antiporter
H0S56_01415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0S56_01430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0S56_01435	COG4221	oxidoreductase activity
H0S56_01440	COG2873	o-acetylhomoserine
H0S56_01445	COG0488	(ABC) transporter
H0S56_01465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S56_01480	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0S56_01500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0S56_01505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0S56_01510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0S56_01515	COG2226	methyltransferase
H0S56_01520	COG3385	transposase activity
H0S56_01570	COG0067	glutamate synthase
H0S56_01570	COG0070	glutamate synthase
H0S56_01570	COG0069	glutamate synthase activity
H0S56_01575	COG0493	'glutamate synthase
H0S56_01580	COG1704	LemA family
H0S56_01600	COG3307	-O-antigen
H0S56_01610	COG3307	-O-antigen
H0S56_01635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0S56_01640	COG1758	RNA polymerase activity
H0S56_01645	COG0194	GDP metabolic process
H0S56_01690	COG0228	four-way junction DNA binding
H0S56_01695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0S56_01705	COG0335	large ribosomal subunit rRNA binding
H0S56_01715	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H0S56_01725	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H0S56_01730	COG5380	lipid catabolic process
H0S56_01735	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H0S56_01755	COG5006	permease, DMT superfamily
H0S56_01760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0S56_01765	COG0277	FAD linked oxidase domain protein
H0S56_01780	COG2814	Major facilitator Superfamily
H0S56_01785	COG1289	transmembrane transporter activity
H0S56_01795	COG0628	permease
H0S56_01815	COG2226	methyltransferase
H0S56_01830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H0S56_01835	COG0254	rRNA binding
H0S56_01840	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S56_01850	COG0534	Mate efflux family protein
H0S56_01860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0S56_01870	COG1278	Cold shock
H0S56_01875	COG1960	acyl-CoA dehydrogenase activity
H0S56_01890	COG0408	coproporphyrinogen oxidase activity
H0S56_01895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0S56_01915	COG0513	Belongs to the DEAD box helicase family
H0S56_01920	COG1127	ABC transporter
H0S56_01925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0S56_01930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H0S56_01945	COG0598	Magnesium transport protein CorA
H0S56_01955	COG0494	nUDIX hydrolase
H0S56_01960	COG1040	competence protein
H0S56_01965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0S56_01975	COG2937	Belongs to the GPAT DAPAT family
H0S56_01980	COG1946	Acyl-CoA thioesterase
H0S56_01985	COG1301	dicarboxylic acid transport
H0S56_01995	COG1959	2 iron, 2 sulfur cluster binding
H0S56_02000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S56_02000	COG1017	nitric oxide dioxygenase activity
H0S56_02005	COG0433	COG0433 Predicted ATPase
H0S56_02010	COG0626	cystathionine gamma-synthase activity
H0S56_02030	COG0088	Forms part of the polypeptide exit tunnel
H0S56_02035	COG0089	rRNA binding
H0S56_02045	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H0S56_02095	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H0S56_02100	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H0S56_02110	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H0S56_02135	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H0S56_02145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H0S56_02150	COG0202	RNA polymerase activity
H0S56_02155	COG0203	ribosomal protein L17
H0S56_02160	COG2072	flavoprotein involved in K transport
H0S56_02170	COG1960	acyl-CoA dehydrogenase activity
H0S56_02175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H0S56_02205	COG0697	spore germination
H0S56_02215	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H0S56_02220	COG0339	signal peptide processing
H0S56_02230	COG0557	exoribonuclease II activity
H0S56_02270	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0S56_02295	COG1295	ribonuclease BN
H0S56_02350	COG1702	phosphate starvation-inducible protein PhoH
H0S56_02355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0S56_02360	COG1196	nuclear chromosome segregation
H0S56_02360	COG0741	lytic transglycosylase activity
H0S56_02360	COG0739	heme binding
H0S56_02400	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H0S56_02405	COG1183	phosphatidylcholine synthase activity
H0S56_02440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S56_02470	COG1607	acyl-coa hydrolase
H0S56_02500	COG2350	Protein conserved in bacteria
H0S56_02515	COG3781	membrane
H0S56_02520	COG2003	Belongs to the UPF0758 family
H0S56_02525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H0S56_02535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0S56_02590	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H0S56_02595	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H0S56_02605	COG2205	protein histidine kinase activity
H0S56_02610	COG0745	RESPONSE REGULATOR receiver
H0S56_02625	COG0174	glutamine synthetase
H0S56_02635	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H0S56_02645	COG0732	type I restriction modification DNA specificity domain
H0S56_02660	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H0S56_02675	COG2814	Major facilitator Superfamily
H0S56_02700	COG3622	Belongs to the hyi family
H0S56_02705	COG2084	Dehydrogenase
H0S56_02720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0S56_02735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0S56_02745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0S56_02755	COG1862	Preprotein translocase
H0S56_02770	COG1704	LemA family
H0S56_02780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H0S56_02830	COG0285	dihydrofolate synthase activity
H0S56_02845	COG0450	alkyl hydroperoxide reductase
H0S56_02850	COG0653	protein targeting
H0S56_02860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H0S56_02865	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H0S56_02920	COG2969	positive regulation of protein catabolic process
H0S56_02925	COG0625	glutathione transferase activity
H0S56_02930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0S56_02935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0S56_02940	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H0S56_02945	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0S56_02950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H0S56_02985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0S56_02995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0S56_03000	COG1408	metallophosphoesterase
H0S56_03010	COG0477	Major facilitator Superfamily
H0S56_03015	COG1272	protein, Hemolysin III
H0S56_03035	COG1024	Enoyl-CoA hydratase
H0S56_03035	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S56_03040	COG0183	Belongs to the thiolase family
H0S56_03045	COG2207	Transcriptional regulator
H0S56_03050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H0S56_03055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S56_03070	COG0183	Belongs to the thiolase family
H0S56_03090	COG0833	amino acid
H0S56_03100	COG2233	PERMEase
H0S56_03105	COG1217	gtp-binding protein TYPA
H0S56_03130	COG1902	pentaerythritol trinitrate reductase activity
H0S56_03150	COG0354	folic acid binding
H0S56_03155	COG2132	Multicopper oxidase
H0S56_03195	COG0564	pseudouridine synthase activity
H0S56_03215	COG2824	Alkylphosphonate utilization operon protein PhnA
H0S56_03230	COG0628	permease
H0S56_03240	COG0351	phosphomethylpyrimidine kinase
H0S56_03240	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0S56_03240	COG0352	thiamine-phosphate diphosphorylase activity
H0S56_03255	COG3152	Membrane
H0S56_03270	COG4772	TonB-dependent receptor
H0S56_03275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0S56_03280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H0S56_03280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0S56_03285	COG0745	RESPONSE REGULATOR receiver
H0S56_03290	COG2205	protein histidine kinase activity
H0S56_03305	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S56_03325	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H0S56_03340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S56_03350	COG0713	ATP synthesis coupled electron transport
H0S56_03355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0S56_03360	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S56_03385	COG1278	Cold shock
H0S56_03390	COG0583	DNA-binding transcription factor activity
H0S56_03430	COG0668	transmembrane transport
H0S56_03445	COG2081	HI0933 family
H0S56_03455	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H0S56_03475	COG0004	ammonium transporteR
H0S56_03480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S56_03495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S56_03495	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S56_03515	COG0489	protein tyrosine kinase activity
H0S56_03560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S56_03585	COG0840	transmembrane signaling receptor activity
H0S56_03590	COG0784	Response regulator, receiver
H0S56_03590	COG0643	Histidine kinase
H0S56_03590	COG2198	Histidine kinase
H0S56_03615	COG2832	Protein of unknown function (DUF454)
H0S56_03675	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H0S56_03685	COG1289	transmembrane transporter activity
H0S56_03690	COG2814	Major facilitator Superfamily
H0S56_03700	COG0786	glutamate:sodium symporter activity
H0S56_03705	COG1115	amino acid carrier protein
H0S56_03710	COG2059	Chromate
H0S56_03715	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S56_03725	COG1607	acyl-coa hydrolase
H0S56_03735	COG2814	Major facilitator Superfamily
H0S56_03760	COG0523	cobalamin synthesis protein
H0S56_03765	COG4681	YaeQ
H0S56_03780	COG4251	negative regulation of phosphorylation
H0S56_03780	COG2203	Gaf domain
H0S56_03780	COG3706	GGDEF domain
H0S56_03780	COG5001	Diguanylate cyclase
H0S56_03810	COG0393	Putative heavy-metal-binding
H0S56_03815	COG0393	Putative heavy-metal-binding
H0S56_03830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S56_03835	COG0671	phosphoesterase, PA-phosphatase related
H0S56_03850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H0S56_03860	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H0S56_03870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H0S56_03875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H0S56_03875	COG1648	precorrin-2 dehydrogenase activity
H0S56_03880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H0S56_03890	COG0531	amino acid
H0S56_03905	COG0321	lipoyl(octanoyl) transferase activity
H0S56_03940	COG0586	Pfam SNARE associated Golgi protein
H0S56_03965	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0S56_03990	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H0S56_03995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0S56_04025	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H0S56_04035	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H0S56_04040	COG0358	DNA primase activity
H0S56_04050	COG0564	pseudouridine synthase activity
H0S56_04075	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S56_04100	COG0251	oxidation-reduction process
H0S56_04105	COG1309	transcriptional regulator
H0S56_04115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H0S56_04120	COG0505	Belongs to the CarA family
H0S56_04150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S56_04160	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0S56_04195	COG1253	flavin adenine dinucleotide binding
H0S56_04215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S56_04225	COG2239	Acts as a magnesium transporter
H0S56_04235	COG0501	Belongs to the peptidase M48B family
H0S56_04240	COG0741	lytic transglycosylase activity
H0S56_04240	COG1196	nuclear chromosome segregation
H0S56_04240	COG0739	heme binding
H0S56_04245	COG0037	tRNA processing
H0S56_04260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0S56_04280	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H0S56_04295	COG1716	ATPase activity
H0S56_04295	COG5001	Diguanylate cyclase
H0S56_04300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0S56_04305	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H0S56_04310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H0S56_04355	COG1115	amino acid carrier protein
H0S56_04360	COG1113	amino acid transport
H0S56_04370	COG0019	diaminopimelate decarboxylase activity
H0S56_04385	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H0S56_04395	COG1522	sequence-specific DNA binding
H0S56_04400	COG1280	lysine exporter protein (LysE YggA)
H0S56_04440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S56_04460	COG1671	Belongs to the UPF0178 family
H0S56_04480	COG1136	(ABC) transporter
H0S56_04500	COG2267	carboxylic ester hydrolase activity
H0S56_04510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H0S56_04515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H0S56_04520	COG0628	permease
H0S56_04555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S56_04575	COG0823	Involved in the tonB-independent uptake of proteins
H0S56_04595	COG0824	Thioesterase
H0S56_04600	COG1473	amidohydrolase
H0S56_04615	COG2255	four-way junction helicase activity
H0S56_04635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0S56_04635	COG0047	phosphoribosylformylglycinamidine synthase activity
H0S56_04655	COG0583	DNA-binding transcription factor activity
H0S56_04665	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
H0S56_04680	COG0778	Nitroreductase
H0S56_04690	COG1051	belongs to the nudix hydrolase family
H0S56_04690	COG1056	cytidyltransferase-related domain
H0S56_04695	COG0583	DNA-binding transcription factor activity
H0S56_04705	COG2353	YceI-like domain
H0S56_04710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0S56_04720	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H0S56_04725	COG0602	queuosine metabolic process
H0S56_04745	COG0583	DNA-binding transcription factor activity
H0S56_04750	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H0S56_04755	COG4208	sulfate ABC transporter
H0S56_04770	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0S56_04775	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0S56_04785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H0S56_04805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S56_04820	COG0681	Belongs to the peptidase S26 family
H0S56_04830	COG0571	ribonuclease III activity
H0S56_04835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0S56_04845	COG1381	Involved in DNA repair and RecF pathway recombination
H0S56_04850	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H0S56_04880	COG0436	Aminotransferase
H0S56_04890	COG0052	Belongs to the universal ribosomal protein uS2 family
H0S56_04915	COG2951	lytic endotransglycosylase activity
H0S56_04930	COG0842	Transport permease protein
H0S56_04935	COG1131	(ABC) transporter
H0S56_04945	COG3706	GGDEF domain
H0S56_04980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0S56_05000	COG3634	alkyl hydroperoxide reductase activity
H0S56_05005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S56_05010	COG0826	peptidase U32
H0S56_05040	COG1720	tRNA m6t6A37 methyltransferase activity
H0S56_05050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H0S56_05065	COG0642	Histidine kinase
H0S56_05075	COG0352	thiamine-phosphate diphosphorylase activity
H0S56_05085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0S56_05090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0S56_05095	COG3139	Protein of unknown function (DUF1315)
H0S56_05105	COG1301	dicarboxylic acid transport
H0S56_05115	COG1960	acyl-CoA dehydrogenase activity
H0S56_05120	COG0693	protein deglycase activity
H0S56_05130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0S56_05135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H0S56_05160	COG2252	PERMEase
H0S56_05165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H0S56_05185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0S56_05195	COG0527	aspartate kinase activity
H0S56_05200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H0S56_05205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H0S56_05235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0S56_05255	COG1252	NADH dehydrogenase
H0S56_05260	COG1686	Belongs to the peptidase S11 family
H0S56_05280	COG2351	hydroxyisourate hydrolase activity
H0S56_05305	COG0436	Aminotransferase
H0S56_05310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0S56_05315	COG0386	Belongs to the glutathione peroxidase family
H0S56_05325	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H0S56_05345	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H0S56_05355	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0S56_05360	COG0012	GTP binding
H0S56_05390	COG0204	Acyl-transferase
H0S56_05420	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0S56_05420	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H0S56_05425	COG1254	Belongs to the acylphosphatase family
H0S56_05455	COG3634	alkyl hydroperoxide reductase activity
H0S56_05480	COG1643	Atp-dependent helicase
H0S56_05500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S56_05535	COG0802	atpase or kinase
H0S56_05540	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H0S56_05550	COG1923	regulation of RNA biosynthetic process
H0S56_05555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S56_05565	COG3178	'Phosphotransferase
H0S56_05570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H0S56_05580	COG1192	Involved in chromosome partitioning
H0S56_05585	COG1475	DNA binding
H0S56_05590	COG0811	peptide transport
H0S56_05600	COG1132	(ABC) transporter
H0S56_05605	COG1663	tetraacyldisaccharide 4'-kinase activity
H0S56_05625	COG0084	hydrolase, TatD family'
H0S56_05630	COG1309	transcriptional regulator
H0S56_05660	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H0S56_05680	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H0S56_05690	COG0776	regulation of translation
H0S56_05705	COG2431	L-lysine efflux transmembrane transporter activity
H0S56_05720	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H0S56_05725	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H0S56_05745	COG1253	flavin adenine dinucleotide binding
H0S56_05765	COG0308	aminopeptidase N
H0S56_05775	COG0589	response to stress
H0S56_05780	COG0589	response to stress
H0S56_05795	COG3135	benzoate transporter
H0S56_05805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0S56_05810	COG0583	DNA-binding transcription factor activity
H0S56_05825	COG0183	Belongs to the thiolase family
H0S56_05850	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0S56_05855	COG0824	Thioesterase
H0S56_05860	COG1454	alcohol dehydrogenase
H0S56_05865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0S56_05885	COG0069	glutamate synthase activity
H0S56_05895	COG2308	Evidence 4 Homologs of previously reported genes of
H0S56_05905	COG1305	Transglutaminase-like
H0S56_05920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0S56_05925	COG0305	Participates in initiation and elongation during chromosome replication
H0S56_05940	COG0360	Binds together with S18 to 16S ribosomal RNA
H0S56_05950	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H0S56_05955	COG1845	cytochrome c oxidase, subunit III
H0S56_05960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H0S56_05965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H0S56_05990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S56_06005	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H0S56_06010	COG2890	protein-(glutamine-N5) methyltransferase activity
H0S56_06030	COG1960	acyl-CoA dehydrogenase activity
H0S56_06035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S56_06045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H0S56_06080	COG0477	Major facilitator Superfamily
H0S56_06085	COG0729	surface antigen
H0S56_06125	COG1570	exodeoxyribonuclease VII activity
H0S56_06160	COG0786	glutamate:sodium symporter activity
H0S56_06200	COG3723	Recombinational DNA repair protein, rece pathway
H0S56_06285	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
H0S56_06320	COG3728	DNA packaging
H0S56_06320	COG5484	DNA packaging
H0S56_06500	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H0S56_06535	COG0583	DNA-binding transcription factor activity
H0S56_06540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H0S56_06555	COG1902	pentaerythritol trinitrate reductase activity
H0S56_06555	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S56_06585	COG0148	phosphopyruvate hydratase activity
H0S56_06600	COG3293	Transposase
H0S56_06605	COG0772	Belongs to the SEDS family
H0S56_06615	COG4890	Cyd operon protein YbgT
H0S56_06620	COG1294	oxidase, subunit
H0S56_06670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H0S56_06690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S56_06700	COG0133	tryptophan synthase activity
H0S56_06705	COG0517	IMP dehydrogenase activity
H0S56_06735	COG0612	Peptidase, M16
H0S56_06740	COG0552	protein localization to endoplasmic reticulum
H0S56_06800	COG1960	acyl-CoA dehydrogenase activity
H0S56_06865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0S56_06870	COG0730	response to heat
H0S56_06875	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S56_06880	COG2207	Transcriptional regulator
H0S56_06885	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S56_06890	COG1960	acyl-CoA dehydrogenase activity
H0S56_06895	COG2169	Transcriptional regulator
H0S56_06915	COG1294	oxidase, subunit
H0S56_06925	COG1525	nuclease
H0S56_06980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0S56_06985	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H0S56_06995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0S56_07000	COG2801	Transposase and inactivated derivatives
H0S56_07015	COG2814	Major facilitator Superfamily
H0S56_07020	COG0509	glycine decarboxylation via glycine cleavage system
H0S56_07030	COG1132	(ABC) transporter
H0S56_07035	COG0668	transmembrane transport
H0S56_07040	COG3122	Protein conserved in bacteria
H0S56_07050	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H0S56_07060	COG0640	Transcriptional regulator
H0S56_07065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0S56_07075	COG0789	Transcriptional regulator
H0S56_07090	COG1960	acyl-CoA dehydrogenase activity
H0S56_07095	COG0183	Belongs to the thiolase family
H0S56_07115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S56_07120	COG0183	Belongs to the thiolase family
H0S56_07125	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S56_07130	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0S56_07135	COG3135	benzoate transporter
H0S56_07140	COG1028	Short-chain dehydrogenase reductase Sdr
H0S56_07145	COG0633	Ferredoxin
H0S56_07145	COG0543	2 iron, 2 sulfur cluster binding
H0S56_07150	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H0S56_07155	COG4638	Rieske (2fe-2S)
H0S56_07165	COG4829	muconolactone delta-isomerase
H0S56_07170	COG4948	Mandelate Racemase Muconate Lactonizing
H0S56_07175	COG0583	DNA-binding transcription factor activity
H0S56_07180	COG2814	Major facilitator Superfamily
H0S56_07190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S56_07195	COG0318	PFAM AMP-dependent synthetase and ligase
H0S56_07200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S56_07200	COG1017	nitric oxide dioxygenase activity
H0S56_07215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0S56_07235	COG0439	Biotin carboxylase
H0S56_07245	COG0864	Transcriptional regulator
H0S56_07255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0S56_07280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S56_07285	COG3293	Transposase
H0S56_07290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S56_07290	COG1116	anion transmembrane transporter activity
H0S56_07300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S56_07305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S56_07310	COG0243	molybdopterin cofactor binding
H0S56_07320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H0S56_07330	COG0314	molybdopterin synthase activity
H0S56_07335	COG0521	Mo-molybdopterin cofactor biosynthetic process
H0S56_07335	COG0315	cyclic pyranopterin monophosphate synthase activity
H0S56_07340	COG0303	'Molybdopterin
H0S56_07345	COG0725	ABC transporter, periplasmic molybdate-binding protein
H0S56_07350	COG4149	molybdate abc transporter
H0S56_07355	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H0S56_07360	COG2223	nitrite transmembrane transporter activity
H0S56_07365	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
H0S56_07370	COG2116	formate transmembrane transporter activity
H0S56_07375	COG0515	serine threonine protein kinase
H0S56_07390	COG0583	DNA-binding transcription factor activity
H0S56_07405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S56_07410	COG1309	transcriptional regulator
H0S56_07430	COG1944	ATP diphosphatase activity
H0S56_07435	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H0S56_07435	COG0644	oxidoreductase
H0S56_07445	COG1960	acyl-CoA dehydrogenase activity
H0S56_07450	COG1960	acyl-CoA dehydrogenase activity
H0S56_07455	COG2814	Major facilitator Superfamily
H0S56_07460	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0S56_07465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S56_07470	COG5001	Diguanylate cyclase
H0S56_07475	COG2814	Major facilitator Superfamily
H0S56_07485	COG2814	Major facilitator Superfamily
H0S56_07495	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S56_07500	COG0183	Belongs to the thiolase family
H0S56_07510	COG0235	Class ii aldolase
H0S56_07515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0S56_07520	COG1024	Enoyl-CoA hydratase
H0S56_07530	COG1960	acyl-CoA dehydrogenase activity
H0S56_07545	COG0318	PFAM AMP-dependent synthetase and ligase
H0S56_07550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H0S56_07555	COG2814	Major facilitator Superfamily
H0S56_07590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S56_07595	COG1960	acyl-CoA dehydrogenase activity
H0S56_07600	COG1024	Enoyl-CoA hydratase
H0S56_07615	COG1028	Short-chain dehydrogenase reductase Sdr
H0S56_07630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0S56_07635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H0S56_07640	COG1012	belongs to the aldehyde dehydrogenase family
H0S56_07650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H0S56_07665	COG2194	sulfuric ester hydrolase activity
H0S56_07670	COG0745	RESPONSE REGULATOR receiver
H0S56_07675	COG0642	Histidine kinase
H0S56_07705	COG0596	Alpha beta hydrolase
H0S56_07740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S56_07775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H0S56_07790	COG0439	Biotin carboxylase
H0S56_07815	COG2814	Major facilitator Superfamily
H0S56_07820	COG0753	catalase activity
H0S56_07865	COG0372	Belongs to the citrate synthase family
H0S56_07895	COG0542	response to heat
H0S56_07900	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H0S56_07920	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H0S56_07925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0S56_07930	COG0569	domain protein
H0S56_07935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0S56_07955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0S56_07965	COG1585	Membrane protein implicated in regulation of membrane protease activity
H0S56_07985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S56_07990	COG0776	regulation of translation
H0S56_08015	COG0822	iron-sulfur transferase activity
H0S56_08020	COG0316	Belongs to the HesB IscA family
H0S56_08050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0S56_08060	COG1027	Aspartate ammonia-lyase
H0S56_08065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S56_08095	COG3781	membrane
H0S56_08125	COG0778	Nitroreductase
H0S56_08135	COG0697	spore germination
H0S56_08160	COG0424	maF-like protein
H0S56_08165	COG2850	peptidyl-arginine hydroxylation
H0S56_08190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H0S56_08195	COG0702	epimerase
H0S56_08200	COG0268	Binds directly to 16S ribosomal RNA
H0S56_08215	COG1011	Hydrolase
H0S56_08220	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H0S56_08225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H0S56_08230	COG2137	regulation of response to DNA damage stimulus
H0S56_08245	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S56_08250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H0S56_08265	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S56_08280	COG0575	Belongs to the CDS family
H0S56_08285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0S56_08305	COG3852	Histidine kinase
H0S56_08320	COG2814	Major facilitator Superfamily
H0S56_08355	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H0S56_08360	COG0138	bifunctional purine biosynthesis protein purh
H0S56_08380	COG1464	Belongs to the NlpA lipoprotein family
H0S56_08385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0S56_08390	COG2011	ABC-type metal ion transport system permease component
H0S56_08425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H0S56_08435	COG4122	O-methyltransferase activity
H0S56_08465	COG1538	Outer membrane efflux protein
H0S56_08470	COG1137	ATPase activity
H0S56_08475	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H0S56_08485	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H0S56_08490	COG0517	IMP dehydrogenase activity
H0S56_08490	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0S56_08520	COG0625	glutathione transferase activity
H0S56_08525	COG0505	Belongs to the CarA family
H0S56_08550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H0S56_08560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H0S56_08570	COG2391	methyltransferase activity
H0S56_08625	COG1309	transcriptional regulator
H0S56_08675	COG0352	thiamine-phosphate diphosphorylase activity
H0S56_08690	COG3025	triphosphatase activity
H0S56_08710	COG0612	Peptidase, M16
H0S56_08805	COG2199	diguanylate cyclase activity
H0S56_08805	COG2203	Gaf domain
H0S56_08835	COG4783	chaperone-mediated protein folding
H0S56_08850	COG0501	Belongs to the peptidase M48B family
H0S56_08865	COG0167	dihydroorotate dehydrogenase activity
H0S56_08890	COG0778	Nitroreductase
H0S56_08900	COG0513	Belongs to the DEAD box helicase family
H0S56_08905	COG1278	Cold shock
H0S56_08920	COG2363	Small membrane protein
H0S56_08935	COG0625	glutathione transferase activity
H0S56_08940	COG0659	secondary active sulfate transmembrane transporter activity
H0S56_08945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0S56_08965	COG0318	PFAM AMP-dependent synthetase and ligase
H0S56_08970	COG1309	transcriptional regulator
H0S56_08975	COG1960	acyl-CoA dehydrogenase activity
H0S56_08980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0S56_08985	COG1024	Enoyl-CoA hydratase
H0S56_08990	COG4770	biotin carboxylase activity
H0S56_09005	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S56_09010	COG2031	fatty acid transporter
H0S56_09025	COG0540	Belongs to the ATCase OTCase family
H0S56_09050	COG0667	Aldo Keto reductase
H0S56_09060	COG1765	OsmC-like protein
H0S56_09065	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H0S56_09100	COG0640	Transcriptional regulator
H0S56_09110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0S56_09115	COG4232	protein-disulfide reductase activity
H0S56_09120	COG0745	RESPONSE REGULATOR receiver
H0S56_09125	COG0642	Histidine kinase
H0S56_09135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0S56_09140	COG2072	flavoprotein involved in K transport
H0S56_09145	COG0431	NADPH-dependent FMN reductase
H0S56_09150	COG0798	PFAM Bile acid sodium symporter
H0S56_09160	COG0640	Transcriptional regulator
H0S56_09175	COG2203	Gaf domain
H0S56_09175	COG2199	diguanylate cyclase activity
H0S56_09200	COG0714	Associated with various cellular activities
H0S56_09205	COG2879	small protein
H0S56_09210	COG1966	Carbon starvation protein
H0S56_09215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H0S56_09220	COG1509	lysine 2,3-aminomutase activity
H0S56_09235	COG0254	rRNA binding
H0S56_09255	COG1067	ATP-dependent peptidase activity
H0S56_09260	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H0S56_09265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0S56_09270	COG0583	DNA-binding transcription factor activity
H0S56_09280	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H0S56_09295	COG1686	Belongs to the peptidase S11 family
H0S56_09300	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0S56_09305	COG3293	Transposase
H0S56_09330	COG0482	sulfurtransferase activity
H0S56_09335	COG2915	High frequency lysogenization protein hflD homolog
H0S56_09360	COG0616	signal peptide processing
H0S56_09370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0S56_09380	COG0573	inorganic phosphate transmembrane transporter activity
H0S56_09385	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H0S56_09390	COG0076	glutamate decarboxylase activity
H0S56_09395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H0S56_09410	COG0671	phosphoesterase, PA-phosphatase related
H0S56_09415	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H0S56_09425	COG1733	regulation of RNA biosynthetic process
H0S56_09455	COG0556	nucleotide-excision repair
H0S56_09480	COG2175	clavaminate synthase activity
H0S56_09490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S56_09495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0S56_09500	COG1960	acyl-CoA dehydrogenase activity
H0S56_09510	COG2084	Dehydrogenase
H0S56_09515	COG2233	PERMEase
H0S56_09520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S56_09525	COG0251	oxidation-reduction process
H0S56_09530	COG1335	isochorismatase
H0S56_09535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S56_09540	COG0596	Alpha beta hydrolase
H0S56_09550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S56_09555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0S56_09560	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0S56_09600	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H0S56_09615	COG0174	glutamine synthetase
H0S56_09620	COG0512	Glutamine amidotransferase of anthranilate synthase
H0S56_09625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0S56_09640	COG0302	gtp cyclohydrolase
H0S56_09655	COG3706	GGDEF domain
H0S56_09670	COG3739	integral membrane protein
H0S56_09685	COG1741	Belongs to the pirin family
H0S56_09700	COG1902	pentaerythritol trinitrate reductase activity
H0S56_09700	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S56_09715	COG2203	Gaf domain
H0S56_09715	COG3706	GGDEF domain
H0S56_09715	COG5001	Diguanylate cyclase
H0S56_09715	COG4251	negative regulation of phosphorylation
H0S56_09720	COG0418	dihydroorotase activity
H0S56_09735	COG4771	TonB-dependent receptor
H0S56_09750	COG0833	amino acid
H0S56_09790	COG4239	(ABC) transporter, permease
H0S56_09795	COG4174	ABC transporter (Permease)
H0S56_09800	COG4166	transmembrane transport
H0S56_09805	COG0741	lytic transglycosylase activity
H0S56_09805	COG1388	LysM domain
H0S56_09805	COG0741	lytic transglycosylase activity
H0S56_09805	COG1388	LysM domain
H0S56_09825	COG0657	acetylesterase activity
H0S56_09840	COG3107	peptidoglycan biosynthetic process
H0S56_09855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S56_09860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S56_09870	COG2155	Conserved Protein
H0S56_09875	COG0006	proline dipeptidase activity
H0S56_09910	COG1802	Transcriptional regulator
H0S56_09935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0S56_09945	COG2234	aminopeptidase activity
H0S56_09955	COG3384	dioxygenase
H0S56_09965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0S56_09970	COG2878	Part of a membrane complex involved in electron transport
H0S56_09975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0S56_10000	COG0768	penicillin binding
H0S56_10005	COG0742	ribosomal rna small subunit methyltransferase
H0S56_10065	COG1597	lipid kinase activity
H0S56_10090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H0S56_10115	COG4221	oxidoreductase activity
H0S56_10115	COG3321	synthase
H0S56_10115	COG0604	alcohol dehydrogenase
H0S56_10115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0S56_10120	COG3118	belongs to the thioredoxin family
H0S56_10145	COG3293	Transposase
H0S56_10155	COG2268	Band 7 protein
H0S56_10170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S56_10190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0S56_10195	COG1053	succinate dehydrogenase
H0S56_10200	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H0S56_10235	COG0589	response to stress
H0S56_10255	COG2321	neutral zinc metallopeptidase
H0S56_10260	COG2354	Protein conserved in bacteria
H0S56_10285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H0S56_10290	COG1773	rubredoxin
H0S56_10295	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S56_10300	COG2267	carboxylic ester hydrolase activity
H0S56_10305	COG0583	DNA-binding transcription factor activity
H0S56_10320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0S56_10330	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H0S56_10335	COG4181	ATPase activity
H0S56_10360	COG4771	TonB-dependent receptor
H0S56_10380	COG0306	phosphate transporter
H0S56_10395	COG2852	Protein conserved in bacteria
H0S56_10400	COG2376	Dihydroxyacetone kinase
H0S56_10405	COG2066	Belongs to the glutaminase family
H0S56_10410	COG3706	GGDEF domain
H0S56_10415	COG1028	Short-chain dehydrogenase reductase Sdr
H0S56_10425	COG0525	valine-tRNA ligase activity
H0S56_10440	COG2852	Protein conserved in bacteria
H0S56_10455	COG2323	membrane
H0S56_10460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0S56_10480	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S56_10495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S56_10505	COG0142	geranyltranstransferase activity
H0S56_10510	COG2828	Protein conserved in bacteria
H0S56_10515	COG1113	amino acid transport
H0S56_10545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0S56_10565	COG0424	maF-like protein
H0S56_10570	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H0S56_10575	COG1792	Involved in formation and maintenance of cell shape
H0S56_10580	COG1077	Cell shape determining protein MreB Mrl
H0S56_10585	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S56_10595	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S56_10610	COG3293	Transposase
H0S56_10630	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H0S56_10645	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H0S56_10650	COG2223	nitrite transmembrane transporter activity
H0S56_10660	COG0500	methyltransferase
H0S56_10685	COG0783	Belongs to the Dps family
H0S56_10690	COG1136	(ABC) transporter
H0S56_10695	COG4591	ABC-type transport system involved in lipoprotein release permease component
H0S56_10710	COG2271	Major facilitator Superfamily
H0S56_10735	COG3177	Filamentation induced by cAMP protein fic
H0S56_10780	COG3586	endonuclease activity
H0S56_10835	COG0582	viral genome integration into host DNA
H0S56_10845	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0S56_10850	COG2050	protein possibly involved in aromatic compounds catabolism
H0S56_10860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0S56_10865	COG1090	epimerase
H0S56_10875	COG0420	3'-5' exonuclease activity
H0S56_10890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H0S56_10905	COG0735	belongs to the Fur family
H0S56_10910	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S56_10915	COG2914	Belongs to the UPF0125 (RnfH) family
H0S56_10930	COG0121	glutamine amidotransferase
H0S56_10935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0S56_10940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0S56_10950	COG0756	dUTP diphosphatase activity
H0S56_10955	COG0210	DNA helicase
H0S56_10960	COG2885	chlorophyll binding
H0S56_10965	COG0204	Acyl-transferase
H0S56_10980	COG2894	cell division
H0S56_10995	COG1674	ftsk spoiiie
H0S56_10995	COG0531	amino acid
H0S56_11000	COG0492	ferredoxin-NADP+ reductase activity
H0S56_11005	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H0S56_11015	COG0456	acetyltransferase
H0S56_11025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H0S56_11030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H0S56_11040	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H0S56_11055	COG1981	membrane
H0S56_11060	COG1113	amino acid transport
H0S56_11065	COG0251	oxidation-reduction process
H0S56_11085	COG1652	LysM domain
H0S56_11090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0S56_11095	COG1028	Short-chain dehydrogenase reductase Sdr
H0S56_11100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H0S56_11110	COG1399	metal-binding, possibly nucleic acid-binding protein
H0S56_11115	COG3101	peptidyl-lysine hydroxylation
H0S56_11120	COG0009	L-threonylcarbamoyladenylate synthase
H0S56_11135	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H0S56_11140	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H0S56_11165	COG0339	signal peptide processing
H0S56_11175	COG4166	transmembrane transport
H0S56_11205	COG2193	ferroxidase activity
H0S56_11210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0S56_11215	COG3385	transposase activity
H0S56_11220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0S56_11230	COG1196	nuclear chromosome segregation
H0S56_11240	COG0730	response to heat
H0S56_11265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0S56_11275	COG4106	trans-aconitate 2-methyltransferase activity
H0S56_11285	COG3327	negative regulation of DNA-templated transcription, initiation
H0S56_11290	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H0S56_11295	COG0183	Belongs to the thiolase family
H0S56_11300	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S56_11305	COG1024	Enoyl-CoA hydratase
H0S56_11310	COG1024	Enoyl-CoA hydratase
H0S56_11315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S56_11320	COG2151	metal-sulfur cluster biosynthetic enzyme
H0S56_11325	COG3396	Phenylacetate-CoA oxygenase
H0S56_11330	COG3460	Phenylacetate-CoA oxygenase
H0S56_11335	COG3396	Phenylacetate-CoA oxygenase
H0S56_11340	COG1012	belongs to the aldehyde dehydrogenase family
H0S56_11340	COG2030	dehydratase
H0S56_11345	COG2814	Major facilitator Superfamily
H0S56_11355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0S56_11365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0S56_11400	COG1968	undecaprenyl-diphosphatase activity
H0S56_11405	COG1214	PFAM Peptidase M22, glycoprotease
H0S56_11415	COG0494	nUDIX hydrolase
H0S56_11465	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0S56_11470	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0S56_11535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S56_11540	COG1764	response to oxidative stress
H0S56_11585	COG0037	tRNA processing
H0S56_11595	COG0248	Ppx GppA phosphatase
H0S56_11620	COG0072	phenylalanine-tRNA ligase activity
H0S56_11650	COG1238	metal cluster binding
H0S56_11665	COG0625	glutathione transferase activity
H0S56_11680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H0S56_11700	COG0318	PFAM AMP-dependent synthetase and ligase
H0S56_11715	COG4206	TonB-dependent receptor
H0S56_11720	COG2096	Adenosyltransferase
H0S56_11735	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H0S56_11750	COG0745	RESPONSE REGULATOR receiver
H0S56_11755	COG2205	protein histidine kinase activity
H0S56_11765	COG1960	acyl-CoA dehydrogenase activity
H0S56_11770	COG1960	acyl-CoA dehydrogenase activity
H0S56_11815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H0S56_11860	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H0S56_11870	COG2205	protein histidine kinase activity
H0S56_11885	COG1660	Displays ATPase and GTPase activities
H0S56_11900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H0S56_11905	COG0617	tRNA 3'-terminal CCA addition
H0S56_11910	COG1555	photosystem II stabilization
H0S56_11910	COG1596	polysaccharide export
H0S56_11915	COG3956	TIGRFAM MazG family protein
H0S56_11920	COG0300	oxidoreductase activity
H0S56_11935	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S56_11955	COG1426	Protein conserved in bacteria
H0S56_11975	COG2975	iron-sulfur cluster assembly
H0S56_12005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H0S56_12010	COG0440	acetolactate synthase activity
H0S56_12015	COG0028	Belongs to the TPP enzyme family
H0S56_12040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S56_12045	COG1136	(ABC) transporter
H0S56_12045	COG0577	efflux transmembrane transporter activity
H0S56_12050	COG1538	Outer membrane efflux protein
H0S56_12060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H0S56_12065	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H0S56_12070	COG1162	GTPase activity
H0S56_12080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H0S56_12095	COG0084	hydrolase, TatD family'
H0S56_12110	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H0S56_12120	COG0793	Belongs to the peptidase S41A family
H0S56_12145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H0S56_12150	COG0280	phosphate acetyltransferase
H0S56_12150	COG0857	belongs to the CobB CobQ family
H0S56_12160	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H0S56_12160	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H0S56_12175	COG0740	serine-type endopeptidase activity
H0S56_12185	COG4771	TonB-dependent receptor
H0S56_12190	COG4774	siderophore transport
H0S56_12200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0S56_12210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S56_12210	COG2813	Specifically methylates the guanine in position
H0S56_12325	COG0788	formyltetrahydrofolate deformylase activity
H0S56_12350	COG4651	solute:proton antiporter activity
H0S56_12350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0S56_12370	COG0210	DNA helicase
H0S56_12375	COG1929	Belongs to the glycerate kinase type-1 family
H0S56_12405	COG2900	Belongs to the SlyX family
H0S56_12410	COG0488	(ABC) transporter
H0S56_12415	COG1560	Kdo2-lipid A biosynthetic process
H0S56_12475	COG0473	3-isopropylmalate dehydrogenase activity
H0S56_12490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H0S56_12500	COG0583	DNA-binding transcription factor activity
H0S56_12550	COG0753	catalase activity
H0S56_12555	COG3011	Protein conserved in bacteria
H0S56_12580	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S56_12585	COG3384	dioxygenase
H0S56_12590	COG1028	Short-chain dehydrogenase reductase Sdr
H0S56_12605	COG4638	Rieske (2fe-2S)
H0S56_12610	COG0583	DNA-binding transcription factor activity
H0S56_12630	COG4569	acetaldehyde dehydrogenase (acetylating) activity
H0S56_12635	COG3971	2-oxopent-4-enoate hydratase activity
H0S56_12640	COG0546	phosphoglycolate phosphatase activity
H0S56_12645	COG0564	pseudouridine synthase activity
H0S56_12650	COG1530	ribonuclease E activity
H0S56_12655	COG0318	PFAM AMP-dependent synthetase and ligase
H0S56_12680	COG1983	PspC domain protein
H0S56_12690	COG0471	metal ion transport
H0S56_12710	COG0751	glycine-tRNA ligase activity
H0S56_12730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H0S56_12755	COG0493	'glutamate synthase
H0S56_12765	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H0S56_12770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S56_12785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0S56_12795	COG0644	oxidoreductase
H0S56_12795	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H0S56_12805	COG0425	Belongs to the sulfur carrier protein TusA family
H0S56_12810	COG4535	Mg2 and Co2 transporter CorC
H0S56_12815	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H0S56_12835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0S56_12845	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H0S56_12855	COG0789	Transcriptional regulator
H0S56_12860	COG2841	Protein conserved in bacteria
H0S56_12865	COG1185	polyribonucleotide nucleotidyltransferase activity
H0S56_12870	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H0S56_12875	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S56_12880	COG1074	ATP-dependent DNA helicase activity
H0S56_12885	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H0S56_12915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S56_12945	COG0427	acetyl-CoA hydrolase
H0S56_12950	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H0S56_12980	COG0326	Molecular chaperone. Has ATPase activity
H0S56_12990	COG3047	cAMP biosynthetic process
H0S56_12995	COG2056	Na+-H+ antiporter family
H0S56_13015	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H0S56_13020	COG0085	RNA polymerase activity
H0S56_13025	COG0222	ribosome binding
H0S56_13030	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H0S56_13035	COG0081	regulation of translation
H0S56_13060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H0S56_13090	COG0546	phosphoglycolate phosphatase activity
H0S56_13120	COG0824	Thioesterase
H0S56_13140	COG0181	hydroxymethylbilane synthase activity
H0S56_13150	COG3275	phosphorelay sensor kinase activity
H0S56_13170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H0S56_13195	COG1024	Enoyl-CoA hydratase
H0S56_13195	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S56_13270	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0S56_13305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H0S56_13340	COG3158	transport of potassium into the cell
H0S56_13365	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
H0S56_13380	COG2814	Major facilitator Superfamily
H0S56_13390	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0S56_13390	COG0351	phosphomethylpyrimidine kinase
H0S56_13390	COG0352	thiamine-phosphate diphosphorylase activity
H0S56_13435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S56_13445	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S56_13450	COG3162	membrane
H0S56_13455	COG2205	protein histidine kinase activity
H0S56_13455	COG0784	Response regulator, receiver
H0S56_13470	COG0431	NADPH-dependent FMN reductase
H0S56_13480	COG0415	Belongs to the DNA photolyase family
H0S56_13490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S56_13495	COG3152	Membrane
H0S56_13500	COG0668	transmembrane transport
H0S56_13505	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0S56_13510	COG1519	Transferase
H0S56_13515	COG1902	pentaerythritol trinitrate reductase activity
H0S56_13540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H0S56_13565	COG0426	domain, Protein
H0S56_13565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S56_13570	COG2119	membrane
H0S56_13575	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0S56_13610	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H0S56_13620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0S56_13635	COG0189	ligase activity
H0S56_13650	COG2132	Multicopper oxidase
H0S56_13665	COG1278	Cold shock
H0S56_13670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H0S56_13675	COG0708	Exodeoxyribonuclease III
H0S56_13705	COG3706	GGDEF domain
H0S56_13735	COG1247	-acetyltransferase
H0S56_13780	COG3150	esterase
H0S56_13790	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H0S56_13795	COG2918	glutathione biosynthetic process
H0S56_13810	COG2733	membrane
H0S56_13850	COG0753	catalase activity
H0S56_13885	COG0385	Bile acid
H0S56_13890	COG1335	isochorismatase
H0S56_13895	COG2814	Major facilitator Superfamily
H0S56_13900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S56_13910	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H0S56_13915	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H0S56_13920	COG5001	Diguanylate cyclase
H0S56_13920	COG3300	MHYT domain
H0S56_13925	COG2983	Belongs to the UPF0260 family
H0S56_13930	COG5487	UPF0391 membrane protein
H0S56_13935	COG0728	peptidoglycan biosynthetic process
H0S56_13940	COG3023	N-Acetylmuramoyl-L-alanine amidase
H0S56_13955	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H0S56_13965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S56_13970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H0S56_13975	COG0546	phosphoglycolate phosphatase activity
H0S56_13980	COG1028	Short-chain dehydrogenase reductase Sdr
H0S56_14005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0S56_14005	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H0S56_14010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S56_14015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S56_14020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S56_14025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S56_14030	COG1116	anion transmembrane transporter activity
H0S56_14035	COG1309	transcriptional regulator
H0S56_14045	COG0196	riboflavin kinase activity
H0S56_14050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0S56_14055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H0S56_14060	COG1047	Peptidyl-prolyl cis-trans
H0S56_14075	COG2133	pyrroloquinoline quinone binding
H0S56_14110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0S56_14115	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H0S56_14120	COG2951	lytic endotransglycosylase activity
H0S56_14125	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H0S56_14140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0S56_14165	COG2388	GCN5-related N-acetyl-transferase
H0S56_14170	COG2814	Major facilitator Superfamily
H0S56_14175	COG0861	Integral membrane protein TerC family
H0S56_14185	COG0402	S-adenosylhomocysteine deaminase activity
H0S56_14215	COG0706	membrane insertase activity
H0S56_14220	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H0S56_14225	COG0594	ribonuclease P activity