locus-tag	class	description
I6L23_00025	COG0542	response to heat
I6L23_00030	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6L23_00050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6L23_00055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L23_00060	COG0569	domain protein
I6L23_00065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L23_00085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L23_00095	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L23_00115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L23_00120	COG0776	regulation of translation
I6L23_00145	COG0822	iron-sulfur transferase activity
I6L23_00150	COG0316	Belongs to the HesB IscA family
I6L23_00180	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L23_00190	COG1027	Aspartate ammonia-lyase
I6L23_00195	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L23_00215	COG3293	Transposase
I6L23_00230	COG3781	membrane
I6L23_00260	COG0778	Nitroreductase
I6L23_00270	COG0697	spore germination
I6L23_00295	COG0424	maF-like protein
I6L23_00300	COG2850	peptidyl-arginine hydroxylation
I6L23_00310	COG4585	Histidine kinase
I6L23_00315	COG2197	response regulator
I6L23_00325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L23_00330	COG0702	epimerase
I6L23_00335	COG0268	Binds directly to 16S ribosomal RNA
I6L23_00350	COG1011	Hydrolase
I6L23_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6L23_00360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6L23_00365	COG2137	regulation of response to DNA damage stimulus
I6L23_00380	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L23_00385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L23_00400	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L23_00415	COG0575	Belongs to the CDS family
I6L23_00420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L23_00430	COG0528	UMP kinase activity
I6L23_00440	COG3852	Histidine kinase
I6L23_00455	COG2814	Major facilitator Superfamily
I6L23_00460	COG2814	Major facilitator Superfamily
I6L23_00495	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6L23_00500	COG0138	bifunctional purine biosynthesis protein purh
I6L23_00525	COG1464	Belongs to the NlpA lipoprotein family
I6L23_00530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L23_00535	COG2011	ABC-type metal ion transport system permease component
I6L23_00570	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6L23_00580	COG4122	O-methyltransferase activity
I6L23_00615	COG1137	ATPase activity
I6L23_00620	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6L23_00630	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6L23_00635	COG0517	IMP dehydrogenase activity
I6L23_00635	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L23_00665	COG0625	glutathione transferase activity
I6L23_00670	COG0505	Belongs to the CarA family
I6L23_00690	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L23_00700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6L23_00710	COG2391	methyltransferase activity
I6L23_00765	COG1309	transcriptional regulator
I6L23_00805	COG3293	Transposase
I6L23_00820	COG0352	thiamine-phosphate diphosphorylase activity
I6L23_00835	COG3025	triphosphatase activity
I6L23_00860	COG0612	Peptidase, M16
I6L23_00955	COG2199	diguanylate cyclase activity
I6L23_00955	COG2203	Gaf domain
I6L23_00980	COG4783	chaperone-mediated protein folding
I6L23_00995	COG0501	Belongs to the peptidase M48B family
I6L23_01005	COG1286	toxin biosynthetic process
I6L23_01010	COG0167	dihydroorotate dehydrogenase activity
I6L23_01035	COG0778	Nitroreductase
I6L23_01045	COG0513	Belongs to the DEAD box helicase family
I6L23_01050	COG1278	Cold shock
I6L23_01065	COG2363	Small membrane protein
I6L23_01080	COG0625	glutathione transferase activity
I6L23_01085	COG0659	secondary active sulfate transmembrane transporter activity
I6L23_01090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6L23_01110	COG0318	PFAM AMP-dependent synthetase and ligase
I6L23_01115	COG1309	transcriptional regulator
I6L23_01120	COG1960	acyl-CoA dehydrogenase activity
I6L23_01125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L23_01130	COG1024	Enoyl-CoA hydratase
I6L23_01135	COG4770	biotin carboxylase activity
I6L23_01150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L23_01155	COG2031	fatty acid transporter
I6L23_01170	COG0540	Belongs to the ATCase OTCase family
I6L23_01195	COG0667	Aldo Keto reductase
I6L23_01205	COG1765	OsmC-like protein
I6L23_01210	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L23_01245	COG0640	Transcriptional regulator
I6L23_01260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L23_01270	COG0745	RESPONSE REGULATOR receiver
I6L23_01275	COG0642	Histidine kinase
I6L23_01285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L23_01290	COG2072	flavoprotein involved in K transport
I6L23_01295	COG0431	NADPH-dependent FMN reductase
I6L23_01300	COG0798	PFAM Bile acid sodium symporter
I6L23_01310	COG0640	Transcriptional regulator
I6L23_01325	COG2199	diguanylate cyclase activity
I6L23_01325	COG2203	Gaf domain
I6L23_01350	COG0714	Associated with various cellular activities
I6L23_01355	COG2879	small protein
I6L23_01360	COG1966	Carbon starvation protein
I6L23_01365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6L23_01370	COG1509	lysine 2,3-aminomutase activity
I6L23_01385	COG0254	rRNA binding
I6L23_01405	COG1067	ATP-dependent peptidase activity
I6L23_01410	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6L23_01415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L23_01420	COG0583	DNA-binding transcription factor activity
I6L23_01430	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6L23_01445	COG1686	Belongs to the peptidase S11 family
I6L23_01450	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L23_01465	COG0482	sulfurtransferase activity
I6L23_01495	COG0616	signal peptide processing
I6L23_01500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L23_01510	COG0573	inorganic phosphate transmembrane transporter activity
I6L23_01515	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6L23_01520	COG0076	glutamate decarboxylase activity
I6L23_01525	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L23_01535	COG0671	phosphoesterase, PA-phosphatase related
I6L23_01540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6L23_01555	COG3293	Transposase
I6L23_01565	COG1733	regulation of RNA biosynthetic process
I6L23_01595	COG0556	nucleotide-excision repair
I6L23_01620	COG2175	clavaminate synthase activity
I6L23_01630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L23_01635	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L23_01640	COG1960	acyl-CoA dehydrogenase activity
I6L23_01650	COG2084	Dehydrogenase
I6L23_01655	COG2233	PERMEase
I6L23_01660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L23_01665	COG0251	oxidation-reduction process
I6L23_01670	COG1335	isochorismatase
I6L23_01675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L23_01680	COG0596	Alpha beta hydrolase
I6L23_01690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L23_01695	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L23_01700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L23_01740	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6L23_01755	COG0174	glutamine synthetase
I6L23_01965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L23_02010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L23_02095	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L23_02100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L23_02115	COG0302	gtp cyclohydrolase
I6L23_02145	COG3739	integral membrane protein
I6L23_02160	COG1741	Belongs to the pirin family
I6L23_02175	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L23_02175	COG1902	pentaerythritol trinitrate reductase activity
I6L23_02190	COG2203	Gaf domain
I6L23_02190	COG5001	Diguanylate cyclase
I6L23_02190	COG4251	negative regulation of phosphorylation
I6L23_02190	COG3706	GGDEF domain
I6L23_02195	COG0418	dihydroorotase activity
I6L23_02210	COG4771	TonB-dependent receptor
I6L23_02225	COG0833	amino acid
I6L23_02265	COG4239	(ABC) transporter, permease
I6L23_02270	COG4174	ABC transporter (Permease)
I6L23_02275	COG4166	transmembrane transport
I6L23_02280	COG1388	LysM domain
I6L23_02280	COG0741	lytic transglycosylase activity
I6L23_02280	COG0741	lytic transglycosylase activity
I6L23_02280	COG1388	LysM domain
I6L23_02300	COG0657	acetylesterase activity
I6L23_02315	COG3107	peptidoglycan biosynthetic process
I6L23_02330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L23_02335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L23_02345	COG3293	Transposase
I6L23_02350	COG2155	Conserved Protein
I6L23_02355	COG0006	proline dipeptidase activity
I6L23_02390	COG1802	Transcriptional regulator
I6L23_02420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L23_02430	COG2234	aminopeptidase activity
I6L23_02440	COG3384	dioxygenase
I6L23_02450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L23_02455	COG2878	Part of a membrane complex involved in electron transport
I6L23_02460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L23_02485	COG0768	penicillin binding
I6L23_02490	COG0742	ribosomal rna small subunit methyltransferase
I6L23_02550	COG1597	lipid kinase activity
I6L23_02570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6L23_02595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L23_02595	COG3321	synthase
I6L23_02595	COG4221	oxidoreductase activity
I6L23_02595	COG0604	alcohol dehydrogenase
I6L23_02600	COG3118	belongs to the thioredoxin family
I6L23_02630	COG2268	Band 7 protein
I6L23_02635	COG0726	polysaccharide deacetylase
I6L23_02635	COG1649	PFAM Uncharacterised BCR, COG1649
I6L23_02645	COG1215	transferase activity, transferring glycosyl groups
I6L23_02650	COG1649	PFAM Uncharacterised BCR, COG1649
I6L23_02650	COG0726	polysaccharide deacetylase
I6L23_02655	COG0457	Tetratricopeptide repeat
I6L23_02670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L23_02685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L23_02690	COG1053	succinate dehydrogenase
I6L23_02695	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6L23_02730	COG0589	response to stress
I6L23_02750	COG2321	neutral zinc metallopeptidase
I6L23_02755	COG2354	Protein conserved in bacteria
I6L23_02775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6L23_02780	COG1773	rubredoxin
I6L23_02785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L23_02790	COG2267	carboxylic ester hydrolase activity
I6L23_02795	COG0583	DNA-binding transcription factor activity
I6L23_02810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L23_02820	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6L23_02825	COG4181	ATPase activity
I6L23_02850	COG4771	TonB-dependent receptor
I6L23_02870	COG0306	phosphate transporter
I6L23_02885	COG2376	Dihydroxyacetone kinase
I6L23_02890	COG2066	Belongs to the glutaminase family
I6L23_02895	COG3706	GGDEF domain
I6L23_02910	COG0525	valine-tRNA ligase activity
I6L23_02945	COG2323	membrane
I6L23_02950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L23_02975	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L23_02990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L23_02995	COG0142	geranyltranstransferase activity
I6L23_03000	COG2828	Protein conserved in bacteria
I6L23_03005	COG1113	amino acid transport
I6L23_03035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L23_03050	COG0424	maF-like protein
I6L23_03055	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6L23_03060	COG1792	Involved in formation and maintenance of cell shape
I6L23_03065	COG1077	Cell shape determining protein MreB Mrl
I6L23_03070	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6L23_03080	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6L23_03105	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6L23_03120	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6L23_03125	COG2223	nitrite transmembrane transporter activity
I6L23_03135	COG0500	methyltransferase
I6L23_03160	COG0783	Belongs to the Dps family
I6L23_03165	COG1136	(ABC) transporter
I6L23_03170	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L23_03175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L23_03205	COG3177	Filamentation induced by cAMP protein fic
I6L23_03230	COG1785	Belongs to the alkaline phosphatase family
I6L23_03250	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
I6L23_03260	COG5001	Diguanylate cyclase
I6L23_03260	COG5002	protein histidine kinase activity
I6L23_03305	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6L23_03315	COG3293	Transposase
I6L23_03380	COG0582	viral genome integration into host DNA
I6L23_03390	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6L23_03395	COG2050	protein possibly involved in aromatic compounds catabolism
I6L23_03405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L23_03410	COG1090	epimerase
I6L23_03420	COG0420	3'-5' exonuclease activity
I6L23_03435	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6L23_03450	COG0735	belongs to the Fur family
I6L23_03455	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L23_03475	COG4372	Transposase
I6L23_03490	COG0121	glutamine amidotransferase
I6L23_03495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L23_03500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L23_03505	COG0756	dUTP diphosphatase activity
I6L23_03510	COG0210	DNA helicase
I6L23_03515	COG2885	chlorophyll binding
I6L23_03520	COG0204	Acyl-transferase
I6L23_03535	COG2894	cell division
I6L23_03550	COG1674	ftsk spoiiie
I6L23_03550	COG0531	amino acid
I6L23_03555	COG0492	ferredoxin-NADP+ reductase activity
I6L23_03560	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6L23_03570	COG0456	acetyltransferase
I6L23_03580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L23_03595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6L23_03610	COG1981	membrane
I6L23_03615	COG1113	amino acid transport
I6L23_03620	COG0251	oxidation-reduction process
I6L23_03640	COG1652	LysM domain
I6L23_03645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L23_03650	COG1028	Short-chain dehydrogenase reductase Sdr
I6L23_03655	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6L23_03665	COG1399	metal-binding, possibly nucleic acid-binding protein
I6L23_03670	COG3101	peptidyl-lysine hydroxylation
I6L23_03675	COG3293	Transposase
I6L23_03680	COG0009	L-threonylcarbamoyladenylate synthase
I6L23_03695	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6L23_03700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6L23_03725	COG0339	signal peptide processing
I6L23_03735	COG4166	transmembrane transport
I6L23_03765	COG2193	ferroxidase activity
I6L23_03770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L23_03775	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6L23_03780	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6L23_03790	COG1196	nuclear chromosome segregation
I6L23_03800	COG0730	response to heat
I6L23_03825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L23_03835	COG4106	trans-aconitate 2-methyltransferase activity
I6L23_03845	COG3327	negative regulation of DNA-templated transcription, initiation
I6L23_03850	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6L23_03855	COG0183	Belongs to the thiolase family
I6L23_03860	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L23_03865	COG1024	Enoyl-CoA hydratase
I6L23_03870	COG1024	Enoyl-CoA hydratase
I6L23_03875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L23_03880	COG2151	metal-sulfur cluster biosynthetic enzyme
I6L23_03885	COG3396	Phenylacetate-CoA oxygenase
I6L23_03890	COG3460	Phenylacetate-CoA oxygenase
I6L23_03895	COG3396	Phenylacetate-CoA oxygenase
I6L23_03900	COG1012	belongs to the aldehyde dehydrogenase family
I6L23_03900	COG2030	dehydratase
I6L23_03905	COG2814	Major facilitator Superfamily
I6L23_03920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L23_03930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L23_03945	COG4269	membrane
I6L23_03965	COG1968	undecaprenyl-diphosphatase activity
I6L23_03970	COG1214	PFAM Peptidase M22, glycoprotease
I6L23_03980	COG0494	nUDIX hydrolase
I6L23_04030	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6L23_04035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6L23_04100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L23_04105	COG1764	response to oxidative stress
I6L23_04150	COG0037	tRNA processing
I6L23_04160	COG0248	Ppx GppA phosphatase
I6L23_04185	COG0072	phenylalanine-tRNA ligase activity
I6L23_04215	COG1238	metal cluster binding
I6L23_04225	COG0625	glutathione transferase activity
I6L23_04240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6L23_04260	COG0318	PFAM AMP-dependent synthetase and ligase
I6L23_04275	COG4206	TonB-dependent receptor
I6L23_04280	COG2096	Adenosyltransferase
I6L23_04295	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6L23_04305	COG2315	Protein conserved in bacteria
I6L23_04315	COG0745	RESPONSE REGULATOR receiver
I6L23_04320	COG2205	protein histidine kinase activity
I6L23_04330	COG1960	acyl-CoA dehydrogenase activity
I6L23_04335	COG1960	acyl-CoA dehydrogenase activity
I6L23_04375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6L23_04425	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6L23_04430	COG0675	Transposase, IS605 OrfB family
I6L23_04435	COG2205	protein histidine kinase activity
I6L23_04445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L23_04450	COG1660	Displays ATPase and GTPase activities
I6L23_04465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6L23_04470	COG0617	tRNA 3'-terminal CCA addition
I6L23_04475	COG1555	photosystem II stabilization
I6L23_04480	COG3956	TIGRFAM MazG family protein
I6L23_04485	COG0300	oxidoreductase activity
I6L23_04520	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L23_04540	COG1426	Protein conserved in bacteria
I6L23_04560	COG2975	iron-sulfur cluster assembly
I6L23_04600	COG3293	Transposase
I6L23_04615	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6L23_04620	COG0440	acetolactate synthase activity
I6L23_04625	COG0028	Belongs to the TPP enzyme family
I6L23_04650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L23_04655	COG0577	efflux transmembrane transporter activity
I6L23_04655	COG1136	(ABC) transporter
I6L23_04660	COG1538	Outer membrane efflux protein
I6L23_04670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6L23_04680	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6L23_04685	COG1162	GTPase activity
I6L23_04695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L23_04710	COG0084	hydrolase, TatD family'
I6L23_04725	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6L23_04735	COG0793	Belongs to the peptidase S41A family
I6L23_04760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L23_04765	COG0280	phosphate acetyltransferase
I6L23_04765	COG0857	belongs to the CobB CobQ family
I6L23_04775	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L23_04775	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L23_04780	COG3385	transposase activity
I6L23_04795	COG0740	serine-type endopeptidase activity
I6L23_04805	COG4771	TonB-dependent receptor
I6L23_04810	COG4774	siderophore transport
I6L23_04820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L23_04825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L23_04830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L23_04830	COG2813	Specifically methylates the guanine in position
I6L23_04840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6L23_04940	COG0788	formyltetrahydrofolate deformylase activity
I6L23_04965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L23_04965	COG4651	solute:proton antiporter activity
I6L23_04985	COG0210	DNA helicase
I6L23_04990	COG1929	Belongs to the glycerate kinase type-1 family
I6L23_05020	COG2900	Belongs to the SlyX family
I6L23_05025	COG0488	(ABC) transporter
I6L23_05030	COG1560	Kdo2-lipid A biosynthetic process
I6L23_05090	COG0473	3-isopropylmalate dehydrogenase activity
I6L23_05105	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6L23_05115	COG0583	DNA-binding transcription factor activity
I6L23_05155	COG0753	catalase activity
I6L23_05160	COG3011	Protein conserved in bacteria
I6L23_05180	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L23_05185	COG3384	dioxygenase
I6L23_05190	COG1028	Short-chain dehydrogenase reductase Sdr
I6L23_05205	COG4638	Rieske (2fe-2S)
I6L23_05210	COG0583	DNA-binding transcription factor activity
I6L23_05230	COG4569	acetaldehyde dehydrogenase (acetylating) activity
I6L23_05235	COG3971	2-oxopent-4-enoate hydratase activity
I6L23_05240	COG0546	phosphoglycolate phosphatase activity
I6L23_05245	COG0564	pseudouridine synthase activity
I6L23_05250	COG1530	ribonuclease E activity
I6L23_05255	COG0318	PFAM AMP-dependent synthetase and ligase
I6L23_05280	COG1983	PspC domain protein
I6L23_05290	COG0517	IMP dehydrogenase activity
I6L23_05305	COG0751	glycine-tRNA ligase activity
I6L23_05340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L23_05365	COG0493	'glutamate synthase
I6L23_05375	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6L23_05385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L23_05400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6L23_05410	COG0644	oxidoreductase
I6L23_05410	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6L23_05420	COG0425	Belongs to the sulfur carrier protein TusA family
I6L23_05425	COG4535	Mg2 and Co2 transporter CorC
I6L23_05430	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6L23_05450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L23_05455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L23_05455	COG0475	glutathione-regulated potassium exporter activity
I6L23_05460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6L23_05470	COG0789	Transcriptional regulator
I6L23_05475	COG2841	Protein conserved in bacteria
I6L23_05480	COG0598	Magnesium transport protein CorA
I6L23_05485	COG1185	polyribonucleotide nucleotidyltransferase activity
I6L23_05490	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6L23_05495	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L23_05500	COG1074	ATP-dependent DNA helicase activity
I6L23_05505	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6L23_05535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L23_05565	COG0427	acetyl-CoA hydrolase
I6L23_05570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6L23_05605	COG0326	Molecular chaperone. Has ATPase activity
I6L23_05615	COG3047	cAMP biosynthetic process
I6L23_05620	COG2056	Na+-H+ antiporter family
I6L23_05640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6L23_05645	COG0085	RNA polymerase activity
I6L23_05650	COG0222	ribosome binding
I6L23_05655	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6L23_05660	COG0081	regulation of translation
I6L23_05685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L23_05715	COG0546	phosphoglycolate phosphatase activity
I6L23_05765	COG0181	hydroxymethylbilane synthase activity
I6L23_05775	COG3275	phosphorelay sensor kinase activity
I6L23_05790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L23_05815	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L23_05815	COG1024	Enoyl-CoA hydratase
I6L23_05875	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L23_05915	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L23_05950	COG3158	transport of potassium into the cell
I6L23_05975	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
I6L23_05990	COG2814	Major facilitator Superfamily
I6L23_06000	COG0351	phosphomethylpyrimidine kinase
I6L23_06000	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6L23_06000	COG0352	thiamine-phosphate diphosphorylase activity
I6L23_06005	COG3385	transposase activity
I6L23_06025	COG3706	GGDEF domain
I6L23_06035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L23_06045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L23_06050	COG3162	membrane
I6L23_06055	COG2205	protein histidine kinase activity
I6L23_06055	COG0784	Response regulator, receiver
I6L23_06070	COG0431	NADPH-dependent FMN reductase
I6L23_06075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L23_06090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L23_06095	COG3152	Membrane
I6L23_06100	COG0668	transmembrane transport
I6L23_06105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L23_06110	COG1519	Transferase
I6L23_06115	COG1902	pentaerythritol trinitrate reductase activity
I6L23_06140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6L23_06165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L23_06165	COG0426	domain, Protein
I6L23_06170	COG2119	membrane
I6L23_06175	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L23_06210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6L23_06220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L23_06235	COG0189	ligase activity
I6L23_06250	COG2132	Multicopper oxidase
I6L23_06265	COG1278	Cold shock
I6L23_06270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6L23_06275	COG0708	Exodeoxyribonuclease III
I6L23_06330	COG1247	-acetyltransferase
I6L23_06375	COG3150	esterase
I6L23_06385	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6L23_06390	COG2918	glutathione biosynthetic process
I6L23_06405	COG2733	membrane
I6L23_06445	COG0753	catalase activity
I6L23_06490	COG0385	Bile acid
I6L23_06495	COG1335	isochorismatase
I6L23_06500	COG2814	Major facilitator Superfamily
I6L23_06505	COG3293	Transposase
I6L23_06510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L23_06520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6L23_06525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L23_06530	COG5001	Diguanylate cyclase
I6L23_06530	COG3300	MHYT domain
I6L23_06535	COG2983	Belongs to the UPF0260 family
I6L23_06540	COG5487	UPF0391 membrane protein
I6L23_06545	COG0728	peptidoglycan biosynthetic process
I6L23_06550	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L23_06565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6L23_06575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L23_06580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L23_06585	COG0546	phosphoglycolate phosphatase activity
I6L23_06590	COG1028	Short-chain dehydrogenase reductase Sdr
I6L23_06615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L23_06615	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6L23_06620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L23_06625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L23_06630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L23_06635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L23_06640	COG1116	anion transmembrane transporter activity
I6L23_06645	COG1309	transcriptional regulator
I6L23_06655	COG0196	riboflavin kinase activity
I6L23_06660	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6L23_06665	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6L23_06670	COG1047	Peptidyl-prolyl cis-trans
I6L23_06685	COG2133	pyrroloquinoline quinone binding
I6L23_06720	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L23_06725	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6L23_06730	COG2951	lytic endotransglycosylase activity
I6L23_06735	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6L23_06750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L23_06775	COG2388	GCN5-related N-acetyl-transferase
I6L23_06785	COG0861	Integral membrane protein TerC family
I6L23_06795	COG0402	S-adenosylhomocysteine deaminase activity
I6L23_06825	COG0706	membrane insertase activity
I6L23_06830	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6L23_06835	COG0594	ribonuclease P activity
I6L23_06845	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6L23_06850	COG0592	DNA-directed DNA polymerase activity
I6L23_06860	COG0187	DNA topoisomerase II activity
I6L23_06865	COG1063	alcohol dehydrogenase
I6L23_06870	COG0488	(ABC) transporter
I6L23_06925	COG0657	acetylesterase activity
I6L23_06935	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L23_06965	COG2814	Major facilitator Superfamily
I6L23_06970	COG2814	Major facilitator Superfamily
I6L23_06980	COG0666	response to abiotic stimulus
I6L23_06985	COG0693	protein deglycase activity
I6L23_06995	COG1012	belongs to the aldehyde dehydrogenase family
I6L23_07000	COG0733	neurotransmitter:sodium symporter activity
I6L23_07010	COG0428	transporter
I6L23_07030	COG0675	Transposase, IS605 OrfB family
I6L23_07035	COG0129	dihydroxy-acid dehydratase activity
I6L23_07040	COG0675	Transposase, IS605 OrfB family
I6L23_07060	COG2233	PERMEase
I6L23_07070	COG1309	transcriptional regulator
I6L23_07075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L23_07120	COG1064	alcohol dehydrogenase
I6L23_07125	COG2818	Glycosylase
I6L23_07180	COG1596	polysaccharide export
I6L23_07190	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6L23_07215	COG0438	transferase activity, transferring glycosyl groups
I6L23_07220	COG0438	transferase activity, transferring glycosyl groups
I6L23_07225	COG0438	transferase activity, transferring glycosyl groups
I6L23_07230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6L23_07235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6L23_07245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6L23_07260	COG1216	Glycosyl transferase, family 2
I6L23_07265	COG0438	transferase activity, transferring glycosyl groups
I6L23_07300	COG1216	Glycosyl transferase, family 2
I6L23_07305	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6L23_07310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L23_07325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L23_07335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L23_07365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6L23_07375	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6L23_07380	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6L23_07390	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6L23_07415	COG0281	malic enzyme
I6L23_07500	COG1538	Outer membrane efflux protein
I6L23_07570	COG0582	viral genome integration into host DNA
I6L23_07580	COG3655	Transcriptional regulator
I6L23_07595	COG0271	Belongs to the BolA IbaG family
I6L23_07605	COG1192	Involved in chromosome partitioning
I6L23_07620	COG0586	Pfam SNARE associated Golgi protein
I6L23_07625	COG0519	Catalyzes the synthesis of GMP from XMP
I6L23_07625	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L23_07630	COG3706	GGDEF domain
I6L23_07635	COG3706	GGDEF domain
I6L23_07670	COG0534	Mate efflux family protein
I6L23_07675	COG0436	Aminotransferase
I6L23_07695	COG2837	iron assimilation
I6L23_07705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L23_07710	COG1121	(ABC) transporter
I6L23_07760	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6L23_07775	COG1012	belongs to the aldehyde dehydrogenase family
I6L23_07790	COG0386	Belongs to the glutathione peroxidase family
I6L23_07795	COG0697	spore germination
I6L23_07805	COG0758	DNA mediated transformation
I6L23_07855	COG2814	Major facilitator Superfamily
I6L23_07875	COG0477	Major facilitator Superfamily
I6L23_07880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L23_07915	COG1253	flavin adenine dinucleotide binding
I6L23_07925	COG2860	membrane
I6L23_07930	COG0477	Major facilitator Superfamily
I6L23_07940	COG0318	PFAM AMP-dependent synthetase and ligase
I6L23_07955	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L23_07970	COG0606	chelatase, subunit chli
I6L23_07980	COG0347	Belongs to the P(II) protein family
I6L23_07985	COG0004	ammonium transporteR
I6L23_07995	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L23_07995	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L23_08010	COG0586	Pfam SNARE associated Golgi protein
I6L23_08030	COG0795	lipopolysaccharide-transporting ATPase activity
I6L23_08035	COG0795	lipopolysaccharide-transporting ATPase activity
I6L23_08040	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6L23_08045	COG0793	Belongs to the peptidase S41A family
I6L23_08045	COG3409	Peptidoglycan-binding domain 1 protein
I6L23_08055	COG4191	Histidine kinase
I6L23_08060	COG2197	response regulator
I6L23_08065	COG1686	Belongs to the peptidase S11 family
I6L23_08070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L23_08080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L23_08085	COG4974	Belongs to the 'phage' integrase family
I6L23_08110	COG0772	Belongs to the SEDS family
I6L23_08120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L23_08125	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L23_08135	COG0494	nUDIX hydrolase
I6L23_08150	COG1538	Outer membrane efflux protein
I6L23_08160	COG1132	(ABC) transporter
I6L23_08170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6L23_08180	COG0497	DNA recombination
I6L23_08185	COG3123	guanosine phosphorylase activity
I6L23_08190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L23_08200	COG0237	dephospho-CoA kinase activity
I6L23_08255	COG0779	Required for maturation of 30S ribosomal subunits
I6L23_08260	COG0195	Participates in both transcription termination and antitermination
I6L23_08270	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6L23_08275	COG1320	monovalent cation:proton antiporter activity
I6L23_08280	COG2212	antiporter activity
I6L23_08285	COG1863	multisubunit Na H antiporter MnhE subunit
I6L23_08290	COG0651	ATP synthesis coupled electron transport
I6L23_08295	COG1006	Multisubunit Na H antiporter MnhC subunit
I6L23_08300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L23_08300	COG2111	Na H antiporter
I6L23_08315	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6L23_08320	COG4221	oxidoreductase activity
I6L23_08325	COG2873	o-acetylhomoserine
I6L23_08330	COG0488	(ABC) transporter
I6L23_08350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L23_08365	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L23_08370	COG3385	transposase activity
I6L23_08390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L23_08395	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L23_08400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L23_08405	COG2226	methyltransferase
I6L23_08410	COG3385	transposase activity
I6L23_08460	COG0070	glutamate synthase
I6L23_08460	COG0069	glutamate synthase activity
I6L23_08460	COG0067	glutamate synthase
I6L23_08465	COG0493	'glutamate synthase
I6L23_08470	COG1704	LemA family
I6L23_08485	COG4969	Belongs to the N-Me-Phe pilin family
I6L23_08490	COG3307	-O-antigen
I6L23_08500	COG3307	-O-antigen
I6L23_08525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L23_08530	COG1758	RNA polymerase activity
I6L23_08535	COG0194	GDP metabolic process
I6L23_08580	COG0228	four-way junction DNA binding
I6L23_08585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6L23_08595	COG0335	large ribosomal subunit rRNA binding
I6L23_08600	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6L23_08605	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6L23_08610	COG5380	lipid catabolic process
I6L23_08615	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6L23_08640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L23_08645	COG0277	FAD linked oxidase domain protein
I6L23_08650	COG3385	transposase activity
I6L23_08665	COG2814	Major facilitator Superfamily
I6L23_08670	COG1289	transmembrane transporter activity
I6L23_08680	COG0628	permease
I6L23_08700	COG2226	methyltransferase
I6L23_08715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6L23_08720	COG0254	rRNA binding
I6L23_08725	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L23_08735	COG0534	Mate efflux family protein
I6L23_08745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L23_08750	COG1278	Cold shock
I6L23_08755	COG1960	acyl-CoA dehydrogenase activity
I6L23_08770	COG0408	coproporphyrinogen oxidase activity
I6L23_08775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L23_08795	COG0513	Belongs to the DEAD box helicase family
I6L23_08800	COG1127	ABC transporter
I6L23_08805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6L23_08810	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L23_08825	COG0598	Magnesium transport protein CorA
I6L23_08835	COG0494	nUDIX hydrolase
I6L23_08840	COG1040	competence protein
I6L23_08845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L23_08855	COG2937	Belongs to the GPAT DAPAT family
I6L23_08860	COG1946	Acyl-CoA thioesterase
I6L23_08865	COG1301	dicarboxylic acid transport
I6L23_08875	COG1959	2 iron, 2 sulfur cluster binding
I6L23_08880	COG1017	nitric oxide dioxygenase activity
I6L23_08880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L23_08885	COG0433	COG0433 Predicted ATPase
I6L23_08890	COG0626	cystathionine gamma-synthase activity
I6L23_08910	COG0088	Forms part of the polypeptide exit tunnel
I6L23_08915	COG0089	rRNA binding
I6L23_08925	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6L23_08975	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6L23_08980	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6L23_08990	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6L23_09015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6L23_09025	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6L23_09030	COG0202	RNA polymerase activity
I6L23_09035	COG0203	ribosomal protein L17
I6L23_09040	COG2072	flavoprotein involved in K transport
I6L23_09045	COG1960	acyl-CoA dehydrogenase activity
I6L23_09050	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6L23_09075	COG0697	spore germination
I6L23_09085	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6L23_09090	COG0339	signal peptide processing
I6L23_09100	COG0557	exoribonuclease II activity
I6L23_09140	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6L23_09160	COG1295	ribonuclease BN
I6L23_09215	COG1702	phosphate starvation-inducible protein PhoH
I6L23_09220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6L23_09225	COG0739	heme binding
I6L23_09225	COG0741	lytic transglycosylase activity
I6L23_09225	COG1196	nuclear chromosome segregation
I6L23_09265	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6L23_09270	COG1183	phosphatidylcholine synthase activity
I6L23_09305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L23_09335	COG1607	acyl-coa hydrolase
I6L23_09365	COG2350	Protein conserved in bacteria
I6L23_09380	COG3781	membrane
I6L23_09385	COG2003	Belongs to the UPF0758 family
I6L23_09390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L23_09400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L23_09410	COG2814	Major facilitator Superfamily
I6L23_09435	COG3622	Belongs to the hyi family
I6L23_09440	COG2084	Dehydrogenase
I6L23_09455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L23_09470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L23_09480	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L23_09490	COG1862	Preprotein translocase
I6L23_09510	COG1704	LemA family
I6L23_09520	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6L23_09570	COG0285	dihydrofolate synthase activity
I6L23_09585	COG0450	alkyl hydroperoxide reductase
I6L23_09590	COG0653	protein targeting
I6L23_09600	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6L23_09605	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6L23_09660	COG2969	positive regulation of protein catabolic process
I6L23_09665	COG0625	glutathione transferase activity
I6L23_09670	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6L23_09675	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6L23_09680	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6L23_09685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6L23_09690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L23_09725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L23_09735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L23_09740	COG1408	metallophosphoesterase
I6L23_09750	COG0477	Major facilitator Superfamily
I6L23_09755	COG1272	protein, Hemolysin III
I6L23_09770	COG3293	Transposase
I6L23_09780	COG1024	Enoyl-CoA hydratase
I6L23_09780	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L23_09785	COG0183	Belongs to the thiolase family
I6L23_09790	COG2207	Transcriptional regulator
I6L23_09795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6L23_09800	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L23_09815	COG0183	Belongs to the thiolase family
I6L23_09835	COG0833	amino acid
I6L23_09845	COG2233	PERMEase
I6L23_09850	COG1217	gtp-binding protein TYPA
I6L23_09875	COG1902	pentaerythritol trinitrate reductase activity
I6L23_09895	COG0354	folic acid binding
I6L23_09945	COG0564	pseudouridine synthase activity
I6L23_09970	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L23_09995	COG0352	thiamine-phosphate diphosphorylase activity
I6L23_09995	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6L23_09995	COG0351	phosphomethylpyrimidine kinase
I6L23_10010	COG3152	Membrane
I6L23_10025	COG4772	TonB-dependent receptor
I6L23_10080	COG0732	type I restriction modification DNA specificity domain
I6L23_10090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L23_10100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6L23_10100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L23_10105	COG0745	RESPONSE REGULATOR receiver
I6L23_10110	COG2205	protein histidine kinase activity
I6L23_10120	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L23_10140	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6L23_10155	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L23_10165	COG0713	ATP synthesis coupled electron transport
I6L23_10170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L23_10175	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L23_10200	COG1278	Cold shock
I6L23_10205	COG0583	DNA-binding transcription factor activity
I6L23_10245	COG0668	transmembrane transport
I6L23_10260	COG2081	HI0933 family
I6L23_10270	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6L23_10285	COG0004	ammonium transporteR
I6L23_10290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L23_10305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L23_10305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L23_10315	COG0489	protein tyrosine kinase activity
I6L23_10360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L23_10385	COG0840	transmembrane signaling receptor activity
I6L23_10390	COG0643	Histidine kinase
I6L23_10390	COG0784	Response regulator, receiver
I6L23_10390	COG2198	Histidine kinase
I6L23_10415	COG2832	Protein of unknown function (DUF454)
I6L23_10475	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L23_10485	COG1289	transmembrane transporter activity
I6L23_10500	COG0786	glutamate:sodium symporter activity
I6L23_10505	COG1115	amino acid carrier protein
I6L23_10510	COG2059	Chromate
I6L23_10515	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L23_10525	COG1607	acyl-coa hydrolase
I6L23_10535	COG2814	Major facilitator Superfamily
I6L23_10560	COG0523	cobalamin synthesis protein
I6L23_10565	COG4681	YaeQ
I6L23_10570	COG1285	pathogenesis
I6L23_10580	COG2203	Gaf domain
I6L23_10580	COG3706	GGDEF domain
I6L23_10580	COG4251	negative regulation of phosphorylation
I6L23_10580	COG5001	Diguanylate cyclase
I6L23_10610	COG0393	Putative heavy-metal-binding
I6L23_10615	COG0393	Putative heavy-metal-binding
I6L23_10630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L23_10635	COG0671	phosphoesterase, PA-phosphatase related
I6L23_10650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6L23_10660	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6L23_10670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6L23_10675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L23_10675	COG1648	precorrin-2 dehydrogenase activity
I6L23_10680	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6L23_10690	COG0531	amino acid
I6L23_10705	COG0321	lipoyl(octanoyl) transferase activity
I6L23_10710	COG2921	Belongs to the UPF0250 family
I6L23_10735	COG0586	Pfam SNARE associated Golgi protein
I6L23_10780	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6L23_10785	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L23_10815	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6L23_10825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6L23_10830	COG0358	DNA primase activity
I6L23_10840	COG0564	pseudouridine synthase activity
I6L23_10865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L23_10885	COG0110	maltose O-acetyltransferase activity
I6L23_10890	COG0251	oxidation-reduction process
I6L23_10895	COG1309	transcriptional regulator
I6L23_10905	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6L23_10910	COG0505	Belongs to the CarA family
I6L23_10940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L23_10950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6L23_10985	COG1253	flavin adenine dinucleotide binding
I6L23_11005	COG2239	Acts as a magnesium transporter
I6L23_11015	COG0501	Belongs to the peptidase M48B family
I6L23_11020	COG1196	nuclear chromosome segregation
I6L23_11020	COG0741	lytic transglycosylase activity
I6L23_11020	COG0739	heme binding
I6L23_11025	COG0037	tRNA processing
I6L23_11040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L23_11060	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6L23_11075	COG5001	Diguanylate cyclase
I6L23_11075	COG1716	ATPase activity
I6L23_11080	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L23_11085	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6L23_11090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6L23_11130	COG1115	amino acid carrier protein
I6L23_11135	COG1113	amino acid transport
I6L23_11145	COG0019	diaminopimelate decarboxylase activity
I6L23_11160	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6L23_11170	COG1522	sequence-specific DNA binding
I6L23_11175	COG1280	lysine exporter protein (LysE YggA)
I6L23_11215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L23_11235	COG1671	Belongs to the UPF0178 family
I6L23_11255	COG1136	(ABC) transporter
I6L23_11260	COG2333	competence protein COMEC
I6L23_11260	COG0658	competence protein
I6L23_11275	COG2267	carboxylic ester hydrolase activity
I6L23_11280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L23_11285	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6L23_11290	COG0628	permease
I6L23_11295	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6L23_11325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L23_11345	COG0823	Involved in the tonB-independent uptake of proteins
I6L23_11365	COG0824	Thioesterase
I6L23_11385	COG2255	four-way junction helicase activity
I6L23_11410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L23_11410	COG0047	phosphoribosylformylglycinamidine synthase activity
I6L23_11435	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
I6L23_11440	COG0778	Nitroreductase
I6L23_11450	COG1051	belongs to the nudix hydrolase family
I6L23_11450	COG1056	cytidyltransferase-related domain
I6L23_11455	COG0583	DNA-binding transcription factor activity
I6L23_11465	COG2353	YceI-like domain
I6L23_11470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6L23_11480	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6L23_11485	COG0602	queuosine metabolic process
I6L23_11505	COG0583	DNA-binding transcription factor activity
I6L23_11510	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L23_11515	COG4208	sulfate ABC transporter
I6L23_11530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L23_11535	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L23_11545	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L23_11565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L23_11590	COG0571	ribonuclease III activity
I6L23_11595	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6L23_11605	COG1381	Involved in DNA repair and RecF pathway recombination
I6L23_11610	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6L23_11640	COG0436	Aminotransferase
I6L23_11650	COG0052	Belongs to the universal ribosomal protein uS2 family
I6L23_11675	COG2951	lytic endotransglycosylase activity
I6L23_11690	COG0842	Transport permease protein
I6L23_11695	COG1131	(ABC) transporter
I6L23_11705	COG3706	GGDEF domain
I6L23_11740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L23_11760	COG3634	alkyl hydroperoxide reductase activity
I6L23_11765	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L23_11770	COG0826	peptidase U32
I6L23_11800	COG1720	tRNA m6t6A37 methyltransferase activity
I6L23_11810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L23_11825	COG0642	Histidine kinase
I6L23_11835	COG0494	nUDIX hydrolase
I6L23_11845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L23_11850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6L23_11855	COG3139	Protein of unknown function (DUF1315)
I6L23_11865	COG1301	dicarboxylic acid transport
I6L23_11870	COG1960	acyl-CoA dehydrogenase activity
I6L23_11875	COG0693	protein deglycase activity
I6L23_11885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6L23_11890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6L23_11915	COG2252	PERMEase
I6L23_11920	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L23_11940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6L23_11950	COG0527	aspartate kinase activity
I6L23_11955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6L23_11960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L23_11975	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6L23_11990	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6L23_12010	COG1252	NADH dehydrogenase
I6L23_12015	COG1686	Belongs to the peptidase S11 family
I6L23_12035	COG3293	Transposase
I6L23_12040	COG2351	hydroxyisourate hydrolase activity
I6L23_12065	COG0436	Aminotransferase
I6L23_12070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6L23_12075	COG0386	Belongs to the glutathione peroxidase family
I6L23_12080	COG0436	Aminotransferase
I6L23_12085	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6L23_12105	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6L23_12115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L23_12120	COG0012	GTP binding
I6L23_12155	COG0204	Acyl-transferase
I6L23_12185	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6L23_12185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L23_12190	COG1254	Belongs to the acylphosphatase family
I6L23_12220	COG3634	alkyl hydroperoxide reductase activity
I6L23_12245	COG1643	Atp-dependent helicase
I6L23_12265	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L23_12300	COG0802	atpase or kinase
I6L23_12305	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L23_12315	COG1923	regulation of RNA biosynthetic process
I6L23_12320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L23_12330	COG3178	'Phosphotransferase
I6L23_12335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6L23_12345	COG1192	Involved in chromosome partitioning
I6L23_12350	COG1475	DNA binding
I6L23_12355	COG0811	peptide transport
I6L23_12365	COG1132	(ABC) transporter
I6L23_12370	COG1663	tetraacyldisaccharide 4'-kinase activity
I6L23_12390	COG0084	hydrolase, TatD family'
I6L23_12395	COG1309	transcriptional regulator
I6L23_12425	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6L23_12455	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6L23_12465	COG0776	regulation of translation
I6L23_12485	COG2431	L-lysine efflux transmembrane transporter activity
I6L23_12500	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6L23_12505	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L23_12510	COG3385	transposase activity
I6L23_12530	COG1253	flavin adenine dinucleotide binding
I6L23_12550	COG0308	aminopeptidase N
I6L23_12560	COG0589	response to stress
I6L23_12565	COG0589	response to stress
I6L23_12580	COG3135	benzoate transporter
I6L23_12590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L23_12595	COG0583	DNA-binding transcription factor activity
I6L23_12610	COG0183	Belongs to the thiolase family
I6L23_12640	COG0824	Thioesterase
I6L23_12645	COG1454	alcohol dehydrogenase
I6L23_12650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6L23_12670	COG0069	glutamate synthase activity
I6L23_12680	COG2308	Evidence 4 Homologs of previously reported genes of
I6L23_12690	COG1305	Transglutaminase-like
I6L23_12705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L23_12710	COG0305	Participates in initiation and elongation during chromosome replication
I6L23_12725	COG0360	Binds together with S18 to 16S ribosomal RNA
I6L23_12735	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6L23_12740	COG1845	cytochrome c oxidase, subunit III
I6L23_12745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6L23_12750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6L23_12775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L23_12790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6L23_12795	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L23_12815	COG1960	acyl-CoA dehydrogenase activity
I6L23_12820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L23_12830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L23_12855	COG3293	Transposase
I6L23_12870	COG0477	Major facilitator Superfamily
I6L23_12875	COG0729	surface antigen
I6L23_12915	COG1570	exodeoxyribonuclease VII activity
I6L23_12995	COG3723	Recombinational DNA repair protein, rece pathway
I6L23_13055	COG0305	Participates in initiation and elongation during chromosome replication
I6L23_13085	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6L23_13125	COG3728	DNA packaging
I6L23_13125	COG5484	DNA packaging
I6L23_13185	COG3646	Phage regulatory protein
I6L23_13330	COG0583	DNA-binding transcription factor activity
I6L23_13335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6L23_13350	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L23_13350	COG1902	pentaerythritol trinitrate reductase activity
I6L23_13380	COG0148	phosphopyruvate hydratase activity
I6L23_13395	COG3293	Transposase
I6L23_13400	COG0772	Belongs to the SEDS family
I6L23_13410	COG4890	Cyd operon protein YbgT
I6L23_13415	COG1294	oxidase, subunit
I6L23_13435	COG0537	adenosine 5'-monophosphoramidase activity
I6L23_13465	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6L23_13485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L23_13495	COG3293	Transposase
I6L23_13500	COG0133	tryptophan synthase activity
I6L23_13505	COG0517	IMP dehydrogenase activity
I6L23_13535	COG0612	Peptidase, M16
I6L23_13540	COG0552	protein localization to endoplasmic reticulum
I6L23_13595	COG1960	acyl-CoA dehydrogenase activity
I6L23_13660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L23_13665	COG0730	response to heat
I6L23_13670	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L23_13675	COG2207	Transcriptional regulator
I6L23_13680	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L23_13685	COG1960	acyl-CoA dehydrogenase activity
I6L23_13690	COG2169	Transcriptional regulator
I6L23_13705	COG1271	oxidase subunit
I6L23_13710	COG1294	oxidase, subunit
I6L23_13720	COG1525	nuclease
I6L23_13775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L23_13780	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6L23_13790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L23_13805	COG3293	Transposase
I6L23_13810	COG2814	Major facilitator Superfamily
I6L23_13815	COG0509	glycine decarboxylation via glycine cleavage system
I6L23_13825	COG1132	(ABC) transporter
I6L23_13830	COG0668	transmembrane transport
I6L23_13835	COG3122	Protein conserved in bacteria
I6L23_13855	COG0640	Transcriptional regulator
I6L23_13860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L23_13870	COG0789	Transcriptional regulator
I6L23_13885	COG1960	acyl-CoA dehydrogenase activity
I6L23_13890	COG0183	Belongs to the thiolase family
I6L23_13910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L23_13915	COG0183	Belongs to the thiolase family
I6L23_13920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L23_13925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L23_13930	COG3135	benzoate transporter
I6L23_13935	COG1028	Short-chain dehydrogenase reductase Sdr
I6L23_13940	COG0543	2 iron, 2 sulfur cluster binding
I6L23_13940	COG0633	Ferredoxin
I6L23_13945	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6L23_13950	COG4638	Rieske (2fe-2S)
I6L23_13960	COG4829	muconolactone delta-isomerase
I6L23_13965	COG4948	Mandelate Racemase Muconate Lactonizing
I6L23_13970	COG0583	DNA-binding transcription factor activity
I6L23_13975	COG2814	Major facilitator Superfamily
I6L23_13985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L23_13990	COG0318	PFAM AMP-dependent synthetase and ligase
I6L23_13995	COG1017	nitric oxide dioxygenase activity
I6L23_13995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L23_14010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L23_14030	COG0439	Biotin carboxylase
I6L23_14040	COG3293	Transposase
I6L23_14050	COG3385	transposase activity
I6L23_14055	COG0864	Transcriptional regulator
I6L23_14065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L23_14090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L23_14095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L23_14100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L23_14100	COG1116	anion transmembrane transporter activity
I6L23_14110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L23_14115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L23_14120	COG0243	molybdopterin cofactor binding
I6L23_14130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6L23_14140	COG0314	molybdopterin synthase activity
I6L23_14145	COG0315	cyclic pyranopterin monophosphate synthase activity
I6L23_14145	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L23_14150	COG0303	'Molybdopterin
I6L23_14155	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6L23_14160	COG4149	molybdate abc transporter
I6L23_14165	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6L23_14170	COG2223	nitrite transmembrane transporter activity
I6L23_14175	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6L23_14180	COG2116	formate transmembrane transporter activity
I6L23_14185	COG0515	serine threonine protein kinase
I6L23_14200	COG0583	DNA-binding transcription factor activity
I6L23_14215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L23_14240	COG1944	ATP diphosphatase activity
I6L23_14245	COG0644	oxidoreductase
I6L23_14245	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6L23_14255	COG1960	acyl-CoA dehydrogenase activity
I6L23_14260	COG1960	acyl-CoA dehydrogenase activity
I6L23_14265	COG2814	Major facilitator Superfamily
I6L23_14270	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L23_14275	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L23_14280	COG5001	Diguanylate cyclase
I6L23_14285	COG2814	Major facilitator Superfamily
I6L23_14295	COG2814	Major facilitator Superfamily
I6L23_14305	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L23_14310	COG0183	Belongs to the thiolase family
I6L23_14320	COG0235	Class ii aldolase
I6L23_14325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L23_14330	COG1024	Enoyl-CoA hydratase
I6L23_14340	COG1960	acyl-CoA dehydrogenase activity
I6L23_14355	COG0318	PFAM AMP-dependent synthetase and ligase
I6L23_14360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6L23_14365	COG2814	Major facilitator Superfamily
I6L23_14400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L23_14405	COG1960	acyl-CoA dehydrogenase activity
I6L23_14410	COG1024	Enoyl-CoA hydratase
I6L23_14425	COG1028	Short-chain dehydrogenase reductase Sdr
I6L23_14440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L23_14445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L23_14450	COG1012	belongs to the aldehyde dehydrogenase family
I6L23_14480	COG2351	hydroxyisourate hydrolase activity
I6L23_14485	COG2233	PERMEase
I6L23_14500	COG4266	Belongs to the allantoicase family
I6L23_14505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L23_14510	COG0583	DNA-binding transcription factor activity
I6L23_14530	COG3845	ABC transporter
I6L23_14540	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6L23_14555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6L23_14560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L23_14570	COG2194	sulfuric ester hydrolase activity
I6L23_14575	COG0745	RESPONSE REGULATOR receiver
I6L23_14580	COG0642	Histidine kinase
I6L23_14615	COG2801	Transposase and inactivated derivatives
I6L23_14630	COG0596	Alpha beta hydrolase
I6L23_14660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L23_14700	COG0582	viral genome integration into host DNA
I6L23_14735	COG3561	AntA/AntB antirepressor
I6L23_14990	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6L23_15025	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6L23_15035	COG0439	Biotin carboxylase
I6L23_15055	COG2814	Major facilitator Superfamily
I6L23_15060	COG0753	catalase activity
I6L23_15110	COG0372	Belongs to the citrate synthase family
I6L23_15150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L23_15155	COG4774	siderophore transport
I6L23_15175	COG1454	alcohol dehydrogenase
I6L23_15200	COG4773	Receptor
I6L23_15250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L23_15255	COG4774	siderophore transport
I6L23_15275	COG1454	alcohol dehydrogenase
I6L23_15360	COG0642	Histidine kinase
I6L23_15370	COG2186	Transcriptional regulator
I6L23_15380	COG4628	conserved protein (DUF2132)
I6L23_15405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6L23_15410	COG3550	peptidyl-serine autophosphorylation
I6L23_15445	COG3540	Alkaline phosphatase
I6L23_15455	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L23_15455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L23_15460	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L23_15465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L23_15465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L23_15465	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6L23_15490	COG0475	glutathione-regulated potassium exporter activity
I6L23_15490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L23_15510	COG1309	transcriptional regulator
I6L23_15515	COG0604	alcohol dehydrogenase
I6L23_15520	COG3328	transposase activity
I6L23_15590	COG0730	response to heat
I6L23_15595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L23_15600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6L23_15610	COG3293	Transposase
I6L23_15620	COG3293	Transposase
I6L23_15635	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6L23_15665	COG3328	transposase activity
I6L23_15685	COG0579	oxidoreductase
I6L23_15700	COG3293	Transposase
I6L23_15715	COG2130	NADP-dependent
I6L23_15720	COG1309	transcriptional regulator
I6L23_15730	COG1902	pentaerythritol trinitrate reductase activity
I6L23_15740	COG1979	alcohol dehydrogenase
I6L23_15755	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6L23_15770	COG0604	alcohol dehydrogenase
I6L23_15770	COG3321	synthase
I6L23_15775	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6L23_15780	COG0583	DNA-binding transcription factor activity
I6L23_15785	COG4221	oxidoreductase activity
I6L23_15810	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L23_15815	COG0431	NADPH-dependent FMN reductase
I6L23_15820	COG0798	PFAM Bile acid sodium symporter
I6L23_15825	COG0640	Transcriptional regulator
I6L23_15840	COG1695	Transcriptional regulator
I6L23_15865	COG2963	transposase activity
I6L23_15905	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6L23_16010	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6L23_16025	COG3077	Addiction module antitoxin, RelB DinJ family
I6L23_16040	COG2132	Multicopper oxidase
I6L23_16080	COG2205	protein histidine kinase activity
I6L23_16085	COG3174	membrane
I6L23_16090	COG2217	Heavy metal translocating P-type atpase
I6L23_16150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L23_16155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6L23_16185	COG0789	Transcriptional regulator
I6L23_16210	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6L23_16210	COG3264	Mechanosensitive ion channel
I6L23_16230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L23_16265	COG0542	response to heat
I6L23_16285	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L23_16290	COG1335	isochorismatase
I6L23_16295	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6L23_16305	COG3657	addiction module killer protein
I6L23_16310	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L23_16315	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6L23_16320	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L23_16325	COG0583	DNA-binding transcription factor activity
I6L23_16330	COG3077	Addiction module antitoxin, RelB DinJ family
I6L23_16400	COG3293	Transposase
I6L23_16410	COG1192	Involved in chromosome partitioning
I6L23_16430	COG3385	transposase activity
I6L23_16465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L23_16470	COG4774	siderophore transport
I6L23_16490	COG1454	alcohol dehydrogenase
I6L23_16625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6L23_16635	COG0640	Transcriptional regulator
I6L23_16645	COG0798	PFAM Bile acid sodium symporter
I6L23_16650	COG0431	NADPH-dependent FMN reductase
I6L23_16655	COG0492	ferredoxin-NADP+ reductase activity
I6L23_16700	COG0789	Transcriptional regulator
I6L23_16740	COG1192	Involved in chromosome partitioning
I6L23_16795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6L23_16815	COG3451	type IV secretory pathway VirB4
I6L23_16875	COG3727	T/G mismatch-specific endonuclease activity