locus-tag	class	description
I6L24_00005	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L24_00010	COG2059	Chromate
I6L24_00015	COG1115	amino acid carrier protein
I6L24_00020	COG0786	glutamate:sodium symporter activity
I6L24_00030	COG2814	Major facilitator Superfamily
I6L24_00035	COG1289	transmembrane transporter activity
I6L24_00045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L24_00105	COG2832	Protein of unknown function (DUF454)
I6L24_00130	COG0643	Histidine kinase
I6L24_00130	COG0784	Response regulator, receiver
I6L24_00130	COG2198	Histidine kinase
I6L24_00135	COG0840	transmembrane signaling receptor activity
I6L24_00160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L24_00205	COG0489	protein tyrosine kinase activity
I6L24_00215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L24_00215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L24_00230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L24_00235	COG0004	ammonium transporteR
I6L24_00250	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6L24_00260	COG2081	HI0933 family
I6L24_00275	COG0668	transmembrane transport
I6L24_00315	COG0583	DNA-binding transcription factor activity
I6L24_00320	COG1278	Cold shock
I6L24_00345	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L24_00350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L24_00355	COG0713	ATP synthesis coupled electron transport
I6L24_00365	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L24_00380	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6L24_00400	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L24_00410	COG2205	protein histidine kinase activity
I6L24_00415	COG0745	RESPONSE REGULATOR receiver
I6L24_00430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L24_00465	COG2223	nitrite transmembrane transporter activity
I6L24_00565	COG4772	TonB-dependent receptor
I6L24_00580	COG3152	Membrane
I6L24_00595	COG0351	phosphomethylpyrimidine kinase
I6L24_00595	COG0352	thiamine-phosphate diphosphorylase activity
I6L24_00595	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6L24_00605	COG0628	permease
I6L24_00620	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L24_00640	COG0564	pseudouridine synthase activity
I6L24_00680	COG2132	Multicopper oxidase
I6L24_00685	COG0354	folic acid binding
I6L24_00705	COG1902	pentaerythritol trinitrate reductase activity
I6L24_00730	COG1217	gtp-binding protein TYPA
I6L24_00735	COG2233	PERMEase
I6L24_00745	COG0833	amino acid
I6L24_00765	COG0183	Belongs to the thiolase family
I6L24_00780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L24_00785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6L24_00790	COG2207	Transcriptional regulator
I6L24_00795	COG0183	Belongs to the thiolase family
I6L24_00800	COG1024	Enoyl-CoA hydratase
I6L24_00800	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L24_00820	COG1272	protein, Hemolysin III
I6L24_00825	COG0477	Major facilitator Superfamily
I6L24_00835	COG1408	metallophosphoesterase
I6L24_00840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L24_00855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L24_00890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L24_00895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6L24_00900	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6L24_00905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6L24_00910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6L24_00915	COG0625	glutathione transferase activity
I6L24_00920	COG2969	positive regulation of protein catabolic process
I6L24_00975	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6L24_00980	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6L24_00990	COG0653	protein targeting
I6L24_00995	COG0450	alkyl hydroperoxide reductase
I6L24_01010	COG0285	dihydrofolate synthase activity
I6L24_01060	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6L24_01070	COG1704	LemA family
I6L24_01085	COG1862	Preprotein translocase
I6L24_01095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L24_01105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L24_01135	COG2084	Dehydrogenase
I6L24_01140	COG3622	Belongs to the hyi family
I6L24_01165	COG2814	Major facilitator Superfamily
I6L24_01180	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6L24_01195	COG0732	type I restriction modification DNA specificity domain
I6L24_01205	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6L24_01220	COG0174	glutamine synthetase
I6L24_01235	COG0745	RESPONSE REGULATOR receiver
I6L24_01240	COG2205	protein histidine kinase activity
I6L24_01250	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6L24_01255	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6L24_01260	COG1968	undecaprenyl-diphosphatase activity
I6L24_01310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L24_01320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L24_01325	COG2003	Belongs to the UPF0758 family
I6L24_01330	COG3781	membrane
I6L24_01345	COG2350	Protein conserved in bacteria
I6L24_01360	COG4372	Transposase
I6L24_01390	COG1607	acyl-coa hydrolase
I6L24_01435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L24_01470	COG1183	phosphatidylcholine synthase activity
I6L24_01475	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6L24_01515	COG0741	lytic transglycosylase activity
I6L24_01515	COG0739	heme binding
I6L24_01515	COG1196	nuclear chromosome segregation
I6L24_01520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6L24_01525	COG1702	phosphate starvation-inducible protein PhoH
I6L24_01580	COG1295	ribonuclease BN
I6L24_01585	COG0697	spore germination
I6L24_01600	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6L24_01640	COG0557	exoribonuclease II activity
I6L24_01650	COG0339	signal peptide processing
I6L24_01655	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6L24_01665	COG0697	spore germination
I6L24_01695	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6L24_01700	COG1960	acyl-CoA dehydrogenase activity
I6L24_01705	COG2072	flavoprotein involved in K transport
I6L24_01710	COG0203	ribosomal protein L17
I6L24_01715	COG0202	RNA polymerase activity
I6L24_01720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6L24_01730	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6L24_01755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6L24_01765	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6L24_01770	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6L24_01820	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6L24_01830	COG0089	rRNA binding
I6L24_01835	COG0088	Forms part of the polypeptide exit tunnel
I6L24_01855	COG0626	cystathionine gamma-synthase activity
I6L24_01860	COG0433	COG0433 Predicted ATPase
I6L24_01865	COG1017	nitric oxide dioxygenase activity
I6L24_01865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L24_01870	COG1959	2 iron, 2 sulfur cluster binding
I6L24_01880	COG1301	dicarboxylic acid transport
I6L24_01885	COG1946	Acyl-CoA thioesterase
I6L24_01890	COG2937	Belongs to the GPAT DAPAT family
I6L24_01900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L24_01905	COG1040	competence protein
I6L24_01910	COG0494	nUDIX hydrolase
I6L24_01920	COG0598	Magnesium transport protein CorA
I6L24_01935	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L24_01940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6L24_01945	COG1127	ABC transporter
I6L24_01950	COG0513	Belongs to the DEAD box helicase family
I6L24_01970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L24_01975	COG0408	coproporphyrinogen oxidase activity
I6L24_01990	COG1960	acyl-CoA dehydrogenase activity
I6L24_01995	COG1278	Cold shock
I6L24_02005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L24_02015	COG0534	Mate efflux family protein
I6L24_02025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L24_02030	COG0254	rRNA binding
I6L24_02035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6L24_02050	COG2226	methyltransferase
I6L24_02070	COG0628	permease
I6L24_02080	COG1289	transmembrane transporter activity
I6L24_02085	COG2814	Major facilitator Superfamily
I6L24_02115	COG0277	FAD linked oxidase domain protein
I6L24_02120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L24_02125	COG5006	permease, DMT superfamily
I6L24_02145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6L24_02150	COG5380	lipid catabolic process
I6L24_02155	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6L24_02160	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6L24_02175	COG0335	large ribosomal subunit rRNA binding
I6L24_02185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6L24_02190	COG0228	four-way junction DNA binding
I6L24_02235	COG0194	GDP metabolic process
I6L24_02240	COG1758	RNA polymerase activity
I6L24_02245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L24_02270	COG3307	-O-antigen
I6L24_02280	COG4969	Belongs to the N-Me-Phe pilin family
I6L24_02290	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L24_02295	COG1704	LemA family
I6L24_02300	COG0493	'glutamate synthase
I6L24_02305	COG0070	glutamate synthase
I6L24_02305	COG0069	glutamate synthase activity
I6L24_02305	COG0067	glutamate synthase
I6L24_02355	COG2226	methyltransferase
I6L24_02360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L24_02365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L24_02370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L24_02390	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L24_02405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L24_02425	COG0488	(ABC) transporter
I6L24_02430	COG2873	o-acetylhomoserine
I6L24_02435	COG4221	oxidoreductase activity
I6L24_02440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6L24_02455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L24_02455	COG2111	Na H antiporter
I6L24_02460	COG1006	Multisubunit Na H antiporter MnhC subunit
I6L24_02465	COG0651	ATP synthesis coupled electron transport
I6L24_02470	COG1863	multisubunit Na H antiporter MnhE subunit
I6L24_02475	COG2212	antiporter activity
I6L24_02480	COG1320	monovalent cation:proton antiporter activity
I6L24_02485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6L24_02495	COG0195	Participates in both transcription termination and antitermination
I6L24_02500	COG0779	Required for maturation of 30S ribosomal subunits
I6L24_02555	COG0237	dephospho-CoA kinase activity
I6L24_02565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L24_02570	COG3123	guanosine phosphorylase activity
I6L24_02575	COG0497	DNA recombination
I6L24_02585	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6L24_02595	COG1132	(ABC) transporter
I6L24_02605	COG1538	Outer membrane efflux protein
I6L24_02620	COG0494	nUDIX hydrolase
I6L24_02630	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L24_02635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L24_02645	COG0772	Belongs to the SEDS family
I6L24_02670	COG4974	Belongs to the 'phage' integrase family
I6L24_02675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L24_02685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L24_02690	COG1686	Belongs to the peptidase S11 family
I6L24_02695	COG2197	response regulator
I6L24_02700	COG4191	Histidine kinase
I6L24_02710	COG0793	Belongs to the peptidase S41A family
I6L24_02710	COG3409	Peptidoglycan-binding domain 1 protein
I6L24_02715	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6L24_02720	COG0795	lipopolysaccharide-transporting ATPase activity
I6L24_02725	COG0795	lipopolysaccharide-transporting ATPase activity
I6L24_02745	COG0586	Pfam SNARE associated Golgi protein
I6L24_02760	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L24_02760	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L24_02770	COG0004	ammonium transporteR
I6L24_02775	COG0347	Belongs to the P(II) protein family
I6L24_02785	COG0606	chelatase, subunit chli
I6L24_02800	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L24_02815	COG0318	PFAM AMP-dependent synthetase and ligase
I6L24_02825	COG0477	Major facilitator Superfamily
I6L24_02830	COG2860	membrane
I6L24_02840	COG1253	flavin adenine dinucleotide binding
I6L24_02875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L24_02880	COG0477	Major facilitator Superfamily
I6L24_02900	COG2814	Major facilitator Superfamily
I6L24_02950	COG0758	DNA mediated transformation
I6L24_02960	COG0697	spore germination
I6L24_02965	COG0386	Belongs to the glutathione peroxidase family
I6L24_02980	COG1012	belongs to the aldehyde dehydrogenase family
I6L24_02995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6L24_03045	COG1121	(ABC) transporter
I6L24_03050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L24_03060	COG2837	iron assimilation
I6L24_03080	COG0436	Aminotransferase
I6L24_03085	COG0534	Mate efflux family protein
I6L24_03120	COG3706	GGDEF domain
I6L24_03125	COG3706	GGDEF domain
I6L24_03130	COG1715	Restriction endonuclease
I6L24_03135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L24_03135	COG0519	Catalyzes the synthesis of GMP from XMP
I6L24_03140	COG0586	Pfam SNARE associated Golgi protein
I6L24_03155	COG1192	Involved in chromosome partitioning
I6L24_03165	COG0271	Belongs to the BolA IbaG family
I6L24_03200	COG3756	Protein conserved in bacteria
I6L24_03210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L24_03225	COG0753	catalase activity
I6L24_03250	COG1132	(ABC) transporter
I6L24_03255	COG1538	Outer membrane efflux protein
I6L24_03330	COG3550	peptidyl-serine autophosphorylation
I6L24_03335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6L24_03360	COG4628	conserved protein (DUF2132)
I6L24_03365	COG0281	malic enzyme
I6L24_03385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6L24_03395	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6L24_03400	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6L24_03410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6L24_03450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L24_03460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L24_03475	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L24_03485	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6L24_03495	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6L24_03505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6L24_03515	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6L24_03525	COG1086	Polysaccharide biosynthesis protein
I6L24_03555	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6L24_03565	COG1596	polysaccharide export
I6L24_03610	COG0739	heme binding
I6L24_03620	COG2818	Glycosylase
I6L24_03625	COG1064	alcohol dehydrogenase
I6L24_03670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L24_03690	COG0675	Transposase, IS605 OrfB family
I6L24_03705	COG2233	PERMEase
I6L24_03725	COG0675	Transposase, IS605 OrfB family
I6L24_03730	COG0129	dihydroxy-acid dehydratase activity
I6L24_03745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L24_03750	COG0428	transporter
I6L24_03760	COG0733	neurotransmitter:sodium symporter activity
I6L24_03765	COG1012	belongs to the aldehyde dehydrogenase family
I6L24_03775	COG0693	protein deglycase activity
I6L24_03800	COG2814	Major facilitator Superfamily
I6L24_03805	COG2814	Major facilitator Superfamily
I6L24_03840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L24_03850	COG0657	acetylesterase activity
I6L24_03905	COG0488	(ABC) transporter
I6L24_03910	COG1063	alcohol dehydrogenase
I6L24_03915	COG0187	DNA topoisomerase II activity
I6L24_03925	COG0592	DNA-directed DNA polymerase activity
I6L24_03930	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6L24_03940	COG0594	ribonuclease P activity
I6L24_03945	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6L24_03950	COG0706	membrane insertase activity
I6L24_03980	COG0402	S-adenosylhomocysteine deaminase activity
I6L24_03990	COG0861	Integral membrane protein TerC family
I6L24_04000	COG2388	GCN5-related N-acetyl-transferase
I6L24_04025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L24_04040	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6L24_04045	COG2951	lytic endotransglycosylase activity
I6L24_04050	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6L24_04055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L24_04095	COG2133	pyrroloquinoline quinone binding
I6L24_04110	COG1047	Peptidyl-prolyl cis-trans
I6L24_04115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6L24_04120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6L24_04125	COG0196	riboflavin kinase activity
I6L24_04135	COG1309	transcriptional regulator
I6L24_04140	COG1116	anion transmembrane transporter activity
I6L24_04145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L24_04150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L24_04155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L24_04160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L24_04165	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6L24_04165	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L24_04190	COG1028	Short-chain dehydrogenase reductase Sdr
I6L24_04195	COG0546	phosphoglycolate phosphatase activity
I6L24_04200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L24_04205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L24_04210	COG1309	transcriptional regulator
I6L24_04215	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6L24_04230	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L24_04235	COG0728	peptidoglycan biosynthetic process
I6L24_04240	COG5487	UPF0391 membrane protein
I6L24_04245	COG2983	Belongs to the UPF0260 family
I6L24_04250	COG5001	Diguanylate cyclase
I6L24_04250	COG3300	MHYT domain
I6L24_04255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L24_04260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6L24_04270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L24_04275	COG2814	Major facilitator Superfamily
I6L24_04280	COG1335	isochorismatase
I6L24_04285	COG0385	Bile acid
I6L24_04330	COG0753	catalase activity
I6L24_04375	COG2733	membrane
I6L24_04390	COG2918	glutathione biosynthetic process
I6L24_04395	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6L24_04400	COG3385	transposase activity
I6L24_04410	COG3150	esterase
I6L24_04460	COG1247	-acetyltransferase
I6L24_04490	COG3706	GGDEF domain
I6L24_04520	COG0708	Exodeoxyribonuclease III
I6L24_04525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6L24_04530	COG1278	Cold shock
I6L24_04545	COG2132	Multicopper oxidase
I6L24_04560	COG0189	ligase activity
I6L24_04575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L24_04585	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6L24_04620	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L24_04635	COG4372	Transposase
I6L24_04640	COG2119	membrane
I6L24_04645	COG0426	domain, Protein
I6L24_04645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L24_04670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6L24_04695	COG1902	pentaerythritol trinitrate reductase activity
I6L24_04700	COG1519	Transferase
I6L24_04705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L24_04710	COG0668	transmembrane transport
I6L24_04715	COG3152	Membrane
I6L24_04720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L24_04730	COG0415	Belongs to the DNA photolyase family
I6L24_04735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L24_04740	COG0431	NADPH-dependent FMN reductase
I6L24_04755	COG0784	Response regulator, receiver
I6L24_04755	COG2205	protein histidine kinase activity
I6L24_04760	COG3162	membrane
I6L24_04765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L24_04775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L24_04785	COG3706	GGDEF domain
I6L24_04805	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6L24_04805	COG0352	thiamine-phosphate diphosphorylase activity
I6L24_04805	COG0351	phosphomethylpyrimidine kinase
I6L24_04815	COG2814	Major facilitator Superfamily
I6L24_04830	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
I6L24_04855	COG3158	transport of potassium into the cell
I6L24_04890	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L24_04925	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L24_04995	COG1024	Enoyl-CoA hydratase
I6L24_04995	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L24_05020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L24_05040	COG3275	phosphorelay sensor kinase activity
I6L24_05050	COG0181	hydroxymethylbilane synthase activity
I6L24_05070	COG0824	Thioesterase
I6L24_05100	COG0546	phosphoglycolate phosphatase activity
I6L24_05130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L24_05155	COG0081	regulation of translation
I6L24_05160	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6L24_05165	COG0222	ribosome binding
I6L24_05170	COG0085	RNA polymerase activity
I6L24_05175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6L24_05195	COG2056	Na+-H+ antiporter family
I6L24_05200	COG3047	cAMP biosynthetic process
I6L24_05210	COG0326	Molecular chaperone. Has ATPase activity
I6L24_05245	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6L24_05250	COG0427	acetyl-CoA hydrolase
I6L24_05280	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L24_05310	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6L24_05315	COG1074	ATP-dependent DNA helicase activity
I6L24_05320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L24_05325	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6L24_05330	COG1185	polyribonucleotide nucleotidyltransferase activity
I6L24_05335	COG0598	Magnesium transport protein CorA
I6L24_05340	COG2841	Protein conserved in bacteria
I6L24_05345	COG0789	Transcriptional regulator
I6L24_05355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6L24_05360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L24_05360	COG0475	glutathione-regulated potassium exporter activity
I6L24_05365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L24_05390	COG4535	Mg2 and Co2 transporter CorC
I6L24_05395	COG0425	Belongs to the sulfur carrier protein TusA family
I6L24_05400	COG0644	oxidoreductase
I6L24_05400	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6L24_05410	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6L24_05425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L24_05435	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6L24_05445	COG0493	'glutamate synthase
I6L24_05470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L24_05490	COG0751	glycine-tRNA ligase activity
I6L24_05505	COG0517	IMP dehydrogenase activity
I6L24_05510	COG0471	metal ion transport
I6L24_05520	COG1983	PspC domain protein
I6L24_05545	COG0318	PFAM AMP-dependent synthetase and ligase
I6L24_05550	COG1530	ribonuclease E activity
I6L24_05555	COG0564	pseudouridine synthase activity
I6L24_05560	COG0546	phosphoglycolate phosphatase activity
I6L24_05565	COG3971	2-oxopent-4-enoate hydratase activity
I6L24_05570	COG4569	acetaldehyde dehydrogenase (acetylating) activity
I6L24_05600	COG0583	DNA-binding transcription factor activity
I6L24_05605	COG4638	Rieske (2fe-2S)
I6L24_05620	COG1028	Short-chain dehydrogenase reductase Sdr
I6L24_05625	COG3384	dioxygenase
I6L24_05630	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L24_05655	COG3011	Protein conserved in bacteria
I6L24_05660	COG0753	catalase activity
I6L24_05710	COG0583	DNA-binding transcription factor activity
I6L24_05720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6L24_05735	COG0473	3-isopropylmalate dehydrogenase activity
I6L24_05795	COG1560	Kdo2-lipid A biosynthetic process
I6L24_05800	COG0488	(ABC) transporter
I6L24_05805	COG2900	Belongs to the SlyX family
I6L24_05835	COG1929	Belongs to the glycerate kinase type-1 family
I6L24_05840	COG0210	DNA helicase
I6L24_05860	COG4651	solute:proton antiporter activity
I6L24_05860	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L24_05885	COG0788	formyltetrahydrofolate deformylase activity
I6L24_05960	COG4372	Transposase
I6L24_06010	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6L24_06020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L24_06020	COG2813	Specifically methylates the guanine in position
I6L24_06025	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L24_06030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L24_06040	COG4774	siderophore transport
I6L24_06045	COG4372	Transposase
I6L24_06060	COG4771	TonB-dependent receptor
I6L24_06070	COG0740	serine-type endopeptidase activity
I6L24_06085	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L24_06085	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L24_06095	COG0280	phosphate acetyltransferase
I6L24_06095	COG0857	belongs to the CobB CobQ family
I6L24_06100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L24_06125	COG0793	Belongs to the peptidase S41A family
I6L24_06135	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6L24_06150	COG0084	hydrolase, TatD family'
I6L24_06165	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L24_06175	COG1162	GTPase activity
I6L24_06180	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6L24_06190	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6L24_06200	COG1538	Outer membrane efflux protein
I6L24_06205	COG0577	efflux transmembrane transporter activity
I6L24_06205	COG1136	(ABC) transporter
I6L24_06210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L24_06240	COG0028	Belongs to the TPP enzyme family
I6L24_06245	COG0440	acetolactate synthase activity
I6L24_06250	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6L24_06310	COG2975	iron-sulfur cluster assembly
I6L24_06330	COG1426	Protein conserved in bacteria
I6L24_06350	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L24_06365	COG0300	oxidoreductase activity
I6L24_06370	COG3956	TIGRFAM MazG family protein
I6L24_06375	COG1555	photosystem II stabilization
I6L24_06380	COG0617	tRNA 3'-terminal CCA addition
I6L24_06385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6L24_06400	COG1660	Displays ATPase and GTPase activities
I6L24_06405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L24_06415	COG2205	protein histidine kinase activity
I6L24_06425	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6L24_06480	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6L24_06525	COG1960	acyl-CoA dehydrogenase activity
I6L24_06530	COG1960	acyl-CoA dehydrogenase activity
I6L24_06540	COG2205	protein histidine kinase activity
I6L24_06545	COG0745	RESPONSE REGULATOR receiver
I6L24_06550	COG3153	acetyltransferase
I6L24_06555	COG2315	Protein conserved in bacteria
I6L24_06560	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6L24_06575	COG2096	Adenosyltransferase
I6L24_06580	COG4206	TonB-dependent receptor
I6L24_06595	COG0318	PFAM AMP-dependent synthetase and ligase
I6L24_06615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6L24_06635	COG0625	glutathione transferase activity
I6L24_06645	COG1238	metal cluster binding
I6L24_06675	COG0072	phenylalanine-tRNA ligase activity
I6L24_06700	COG0248	Ppx GppA phosphatase
I6L24_06710	COG0037	tRNA processing
I6L24_06755	COG1764	response to oxidative stress
I6L24_06760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L24_06825	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6L24_06830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6L24_06850	COG3293	Transposase
I6L24_06885	COG0494	nUDIX hydrolase
I6L24_06895	COG1214	PFAM Peptidase M22, glycoprotease
I6L24_06900	COG1968	undecaprenyl-diphosphatase activity
I6L24_06920	COG4269	membrane
I6L24_06945	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L24_06955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L24_06975	COG2814	Major facilitator Superfamily
I6L24_06980	COG2030	dehydratase
I6L24_06980	COG1012	belongs to the aldehyde dehydrogenase family
I6L24_06985	COG3396	Phenylacetate-CoA oxygenase
I6L24_06990	COG3460	Phenylacetate-CoA oxygenase
I6L24_06995	COG3396	Phenylacetate-CoA oxygenase
I6L24_07000	COG2151	metal-sulfur cluster biosynthetic enzyme
I6L24_07005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L24_07010	COG1024	Enoyl-CoA hydratase
I6L24_07015	COG1024	Enoyl-CoA hydratase
I6L24_07020	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L24_07025	COG0183	Belongs to the thiolase family
I6L24_07030	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6L24_07035	COG3327	negative regulation of DNA-templated transcription, initiation
I6L24_07045	COG4106	trans-aconitate 2-methyltransferase activity
I6L24_07055	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L24_07080	COG0730	response to heat
I6L24_07090	COG1196	nuclear chromosome segregation
I6L24_07100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6L24_07105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L24_07110	COG2193	ferroxidase activity
I6L24_07140	COG4166	transmembrane transport
I6L24_07150	COG0339	signal peptide processing
I6L24_07175	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6L24_07180	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6L24_07195	COG0009	L-threonylcarbamoyladenylate synthase
I6L24_07200	COG3101	peptidyl-lysine hydroxylation
I6L24_07205	COG1399	metal-binding, possibly nucleic acid-binding protein
I6L24_07215	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6L24_07220	COG1028	Short-chain dehydrogenase reductase Sdr
I6L24_07225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L24_07230	COG1652	LysM domain
I6L24_07250	COG0251	oxidation-reduction process
I6L24_07255	COG1113	amino acid transport
I6L24_07260	COG1981	membrane
I6L24_07275	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6L24_07290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L24_07300	COG0456	acetyltransferase
I6L24_07310	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6L24_07315	COG0492	ferredoxin-NADP+ reductase activity
I6L24_07320	COG0531	amino acid
I6L24_07320	COG1674	ftsk spoiiie
I6L24_07335	COG2894	cell division
I6L24_07350	COG0204	Acyl-transferase
I6L24_07355	COG2885	chlorophyll binding
I6L24_07360	COG0210	DNA helicase
I6L24_07365	COG0756	dUTP diphosphatase activity
I6L24_07370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L24_07375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L24_07380	COG0121	glutamine amidotransferase
I6L24_07395	COG2914	Belongs to the UPF0125 (RnfH) family
I6L24_07400	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L24_07405	COG0735	belongs to the Fur family
I6L24_07420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6L24_07435	COG0420	3'-5' exonuclease activity
I6L24_07450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L24_07460	COG2050	protein possibly involved in aromatic compounds catabolism
I6L24_07465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6L24_07475	COG0582	viral genome integration into host DNA
I6L24_07560	COG4372	Transposase
I6L24_07590	COG0443	Heat shock 70 kDa protein
I6L24_07595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L24_07615	COG3177	Filamentation induced by cAMP protein fic
I6L24_07635	COG2271	Major facilitator Superfamily
I6L24_07650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L24_07660	COG1136	(ABC) transporter
I6L24_07665	COG0783	Belongs to the Dps family
I6L24_07690	COG0500	methyltransferase
I6L24_07700	COG2223	nitrite transmembrane transporter activity
I6L24_07705	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6L24_07720	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6L24_07750	COG2826	transposase and inactivated derivatives, IS30 family
I6L24_07765	COG2826	transposase and inactivated derivatives, IS30 family
I6L24_07775	COG2826	transposase and inactivated derivatives, IS30 family
I6L24_07785	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6L24_07795	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6L24_07800	COG1077	Cell shape determining protein MreB Mrl
I6L24_07805	COG1792	Involved in formation and maintenance of cell shape
I6L24_07810	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6L24_07815	COG0424	maF-like protein
I6L24_07830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L24_07840	COG0560	Phosphoserine phosphatase
I6L24_07860	COG1113	amino acid transport
I6L24_07865	COG2828	Protein conserved in bacteria
I6L24_07875	COG0142	geranyltranstransferase activity
I6L24_07880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L24_07895	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L24_07915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L24_07920	COG2323	membrane
I6L24_07945	COG2826	transposase and inactivated derivatives, IS30 family
I6L24_07955	COG0525	valine-tRNA ligase activity
I6L24_07965	COG1028	Short-chain dehydrogenase reductase Sdr
I6L24_07970	COG3706	GGDEF domain
I6L24_07975	COG2066	Belongs to the glutaminase family
I6L24_07980	COG2376	Dihydroxyacetone kinase
I6L24_07985	COG2852	Protein conserved in bacteria
I6L24_08005	COG0306	phosphate transporter
I6L24_08010	COG2826	transposase and inactivated derivatives, IS30 family
I6L24_08035	COG4771	TonB-dependent receptor
I6L24_08065	COG4181	ATPase activity
I6L24_08070	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6L24_08080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L24_08095	COG0583	DNA-binding transcription factor activity
I6L24_08100	COG2267	carboxylic ester hydrolase activity
I6L24_08105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L24_08110	COG1773	rubredoxin
I6L24_08115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6L24_08145	COG2354	Protein conserved in bacteria
I6L24_08150	COG2321	neutral zinc metallopeptidase
I6L24_08190	COG0589	response to stress
I6L24_08225	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6L24_08230	COG1053	succinate dehydrogenase
I6L24_08235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L24_08250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L24_08265	COG2268	Band 7 protein
I6L24_08295	COG3118	belongs to the thioredoxin family
I6L24_08300	COG0604	alcohol dehydrogenase
I6L24_08300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L24_08300	COG3321	synthase
I6L24_08300	COG4221	oxidoreductase activity
I6L24_08325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6L24_08345	COG1597	lipid kinase activity
I6L24_08405	COG0742	ribosomal rna small subunit methyltransferase
I6L24_08410	COG0768	penicillin binding
I6L24_08435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L24_08440	COG2878	Part of a membrane complex involved in electron transport
I6L24_08445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L24_08455	COG3384	dioxygenase
I6L24_08465	COG2234	aminopeptidase activity
I6L24_08475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L24_08495	COG1802	Transcriptional regulator
I6L24_08530	COG0006	proline dipeptidase activity
I6L24_08535	COG2155	Conserved Protein
I6L24_08545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L24_08550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L24_08565	COG3107	peptidoglycan biosynthetic process
I6L24_08580	COG0657	acetylesterase activity
I6L24_08600	COG0741	lytic transglycosylase activity
I6L24_08600	COG1388	LysM domain
I6L24_08600	COG0741	lytic transglycosylase activity
I6L24_08600	COG1388	LysM domain
I6L24_08605	COG4166	transmembrane transport
I6L24_08610	COG4174	ABC transporter (Permease)
I6L24_08615	COG4239	(ABC) transporter, permease
I6L24_08655	COG0833	amino acid
I6L24_08685	COG0418	dihydroorotase activity
I6L24_08695	COG5001	Diguanylate cyclase
I6L24_08695	COG3706	GGDEF domain
I6L24_08695	COG4251	negative regulation of phosphorylation
I6L24_08695	COG2203	Gaf domain
I6L24_08710	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L24_08710	COG1902	pentaerythritol trinitrate reductase activity
I6L24_08735	COG1741	Belongs to the pirin family
I6L24_08750	COG3739	integral membrane protein
I6L24_08765	COG3706	GGDEF domain
I6L24_08780	COG0302	gtp cyclohydrolase
I6L24_08795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L24_08800	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L24_08865	COG2199	diguanylate cyclase activity
I6L24_08865	COG2203	Gaf domain
I6L24_08975	COG4383	Mu-like prophage protein gp29
I6L24_09110	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L24_09120	COG0174	glutamine synthetase
I6L24_09135	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6L24_09200	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6L24_09210	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6L24_09220	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6L24_09230	COG2826	transposase and inactivated derivatives, IS30 family
I6L24_09240	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6L24_09250	COG2826	transposase and inactivated derivatives, IS30 family
I6L24_09265	COG2826	transposase and inactivated derivatives, IS30 family
I6L24_09290	COG2826	transposase and inactivated derivatives, IS30 family
I6L24_09325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L24_09330	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L24_09335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L24_09345	COG0596	Alpha beta hydrolase
I6L24_09350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L24_09355	COG1335	isochorismatase
I6L24_09360	COG0251	oxidation-reduction process
I6L24_09365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L24_09370	COG2233	PERMEase
I6L24_09375	COG2084	Dehydrogenase
I6L24_09390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L24_09395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L24_09415	COG2175	clavaminate synthase activity
I6L24_09445	COG0556	nucleotide-excision repair
I6L24_09465	COG1733	regulation of RNA biosynthetic process
I6L24_09475	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6L24_09480	COG0671	phosphoesterase, PA-phosphatase related
I6L24_09490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L24_09495	COG0076	glutamate decarboxylase activity
I6L24_09500	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6L24_09505	COG0573	inorganic phosphate transmembrane transporter activity
I6L24_09515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L24_09520	COG0616	signal peptide processing
I6L24_09550	COG0482	sulfurtransferase activity
I6L24_09570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L24_09575	COG1686	Belongs to the peptidase S11 family
I6L24_09590	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6L24_09600	COG0583	DNA-binding transcription factor activity
I6L24_09605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L24_09610	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6L24_09615	COG1067	ATP-dependent peptidase activity
I6L24_09635	COG0254	rRNA binding
I6L24_09650	COG1509	lysine 2,3-aminomutase activity
I6L24_09655	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6L24_09660	COG1966	Carbon starvation protein
I6L24_09665	COG2879	small protein
I6L24_09670	COG0714	Associated with various cellular activities
I6L24_09715	COG0640	Transcriptional regulator
I6L24_09725	COG0798	PFAM Bile acid sodium symporter
I6L24_09730	COG0431	NADPH-dependent FMN reductase
I6L24_09735	COG2072	flavoprotein involved in K transport
I6L24_09740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L24_09750	COG0642	Histidine kinase
I6L24_09755	COG0745	RESPONSE REGULATOR receiver
I6L24_09760	COG4232	protein-disulfide reductase activity
I6L24_09765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L24_09780	COG0640	Transcriptional regulator
I6L24_09815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L24_09820	COG1765	OsmC-like protein
I6L24_09830	COG0667	Aldo Keto reductase
I6L24_09855	COG0540	Belongs to the ATCase OTCase family
I6L24_09870	COG2031	fatty acid transporter
I6L24_09875	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L24_09890	COG4770	biotin carboxylase activity
I6L24_09895	COG1024	Enoyl-CoA hydratase
I6L24_09900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L24_09905	COG1960	acyl-CoA dehydrogenase activity
I6L24_09910	COG1309	transcriptional regulator
I6L24_09915	COG0318	PFAM AMP-dependent synthetase and ligase
I6L24_09935	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6L24_09940	COG0659	secondary active sulfate transmembrane transporter activity
I6L24_09945	COG0625	glutathione transferase activity
I6L24_09960	COG2363	Small membrane protein
I6L24_09975	COG1278	Cold shock
I6L24_09980	COG0513	Belongs to the DEAD box helicase family
I6L24_09990	COG0778	Nitroreductase
I6L24_10015	COG0167	dihydroorotate dehydrogenase activity
I6L24_10030	COG0501	Belongs to the peptidase M48B family
I6L24_10045	COG4783	chaperone-mediated protein folding
I6L24_10070	COG2199	diguanylate cyclase activity
I6L24_10070	COG2203	Gaf domain
I6L24_10165	COG0612	Peptidase, M16
I6L24_10185	COG3025	triphosphatase activity
I6L24_10200	COG0352	thiamine-phosphate diphosphorylase activity
I6L24_10250	COG1309	transcriptional regulator
I6L24_10305	COG2391	methyltransferase activity
I6L24_10315	COG2826	transposase and inactivated derivatives, IS30 family
I6L24_10320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6L24_10330	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L24_10350	COG0505	Belongs to the CarA family
I6L24_10355	COG0625	glutathione transferase activity
I6L24_10385	COG0517	IMP dehydrogenase activity
I6L24_10385	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L24_10390	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6L24_10400	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6L24_10405	COG1137	ATPase activity
I6L24_10425	COG3385	transposase activity
I6L24_10445	COG4122	O-methyltransferase activity
I6L24_10455	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6L24_10490	COG2011	ABC-type metal ion transport system permease component
I6L24_10495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L24_10500	COG1464	Belongs to the NlpA lipoprotein family
I6L24_10520	COG0138	bifunctional purine biosynthesis protein purh
I6L24_10525	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6L24_10560	COG2814	Major facilitator Superfamily
I6L24_10575	COG3852	Histidine kinase
I6L24_10595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L24_10600	COG0575	Belongs to the CDS family
I6L24_10615	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L24_10630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L24_10635	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L24_10650	COG2137	regulation of response to DNA damage stimulus
I6L24_10655	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6L24_10660	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6L24_10665	COG1011	Hydrolase
I6L24_10680	COG0268	Binds directly to 16S ribosomal RNA
I6L24_10685	COG0702	epimerase
I6L24_10690	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L24_10705	COG4585	Histidine kinase
I6L24_10710	COG2850	peptidyl-arginine hydroxylation
I6L24_10715	COG0424	maF-like protein
I6L24_10740	COG0697	spore germination
I6L24_10750	COG0778	Nitroreductase
I6L24_10780	COG3781	membrane
I6L24_10810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L24_10815	COG1027	Aspartate ammonia-lyase
I6L24_10825	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L24_10855	COG0316	Belongs to the HesB IscA family
I6L24_10860	COG0822	iron-sulfur transferase activity
I6L24_10885	COG0776	regulation of translation
I6L24_10890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L24_10910	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L24_10920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L24_10940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L24_10945	COG0569	domain protein
I6L24_10955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L24_10960	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6L24_10980	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6L24_10985	COG0542	response to heat
I6L24_11015	COG0372	Belongs to the citrate synthase family
I6L24_11060	COG0753	catalase activity
I6L24_11065	COG2814	Major facilitator Superfamily
I6L24_11075	COG2199	diguanylate cyclase activity
I6L24_11085	COG0439	Biotin carboxylase
I6L24_11100	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6L24_11135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L24_11165	COG0596	Alpha beta hydrolase
I6L24_11245	COG2801	Transposase and inactivated derivatives
I6L24_11270	COG0642	Histidine kinase
I6L24_11275	COG0745	RESPONSE REGULATOR receiver
I6L24_11280	COG2194	sulfuric ester hydrolase activity
I6L24_11305	COG1012	belongs to the aldehyde dehydrogenase family
I6L24_11310	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L24_11315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L24_11330	COG1028	Short-chain dehydrogenase reductase Sdr
I6L24_11345	COG1024	Enoyl-CoA hydratase
I6L24_11350	COG1960	acyl-CoA dehydrogenase activity
I6L24_11355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L24_11370	COG0583	DNA-binding transcription factor activity
I6L24_11390	COG2814	Major facilitator Superfamily
I6L24_11395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6L24_11400	COG0318	PFAM AMP-dependent synthetase and ligase
I6L24_11415	COG1960	acyl-CoA dehydrogenase activity
I6L24_11425	COG1024	Enoyl-CoA hydratase
I6L24_11430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L24_11435	COG0235	Class ii aldolase
I6L24_11445	COG0183	Belongs to the thiolase family
I6L24_11450	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L24_11460	COG2814	Major facilitator Superfamily
I6L24_11470	COG2814	Major facilitator Superfamily
I6L24_11475	COG5001	Diguanylate cyclase
I6L24_11480	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L24_11485	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L24_11490	COG2814	Major facilitator Superfamily
I6L24_11495	COG1960	acyl-CoA dehydrogenase activity
I6L24_11500	COG1960	acyl-CoA dehydrogenase activity
I6L24_11510	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6L24_11510	COG0644	oxidoreductase
I6L24_11515	COG1944	ATP diphosphatase activity
I6L24_11535	COG1309	transcriptional regulator
I6L24_11540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L24_11550	COG4771	TonB-dependent receptor
I6L24_11555	COG0583	DNA-binding transcription factor activity
I6L24_11570	COG0515	serine threonine protein kinase
I6L24_11575	COG2116	formate transmembrane transporter activity
I6L24_11580	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6L24_11585	COG2223	nitrite transmembrane transporter activity
I6L24_11590	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6L24_11595	COG4149	molybdate abc transporter
I6L24_11600	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6L24_11605	COG0303	'Molybdopterin
I6L24_11610	COG0315	cyclic pyranopterin monophosphate synthase activity
I6L24_11610	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L24_11615	COG0314	molybdopterin synthase activity
I6L24_11625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6L24_11635	COG0243	molybdopterin cofactor binding
I6L24_11640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L24_11645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L24_11655	COG1116	anion transmembrane transporter activity
I6L24_11655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L24_11660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L24_11665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L24_11690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L24_11700	COG0864	Transcriptional regulator
I6L24_11710	COG0439	Biotin carboxylase
I6L24_11730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L24_11745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L24_11745	COG1017	nitric oxide dioxygenase activity
I6L24_11750	COG0318	PFAM AMP-dependent synthetase and ligase
I6L24_11755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L24_11765	COG2814	Major facilitator Superfamily
I6L24_11770	COG0583	DNA-binding transcription factor activity
I6L24_11775	COG4948	Mandelate Racemase Muconate Lactonizing
I6L24_11780	COG4829	muconolactone delta-isomerase
I6L24_11790	COG4638	Rieske (2fe-2S)
I6L24_11795	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6L24_11800	COG0543	2 iron, 2 sulfur cluster binding
I6L24_11800	COG0633	Ferredoxin
I6L24_11805	COG1028	Short-chain dehydrogenase reductase Sdr
I6L24_11810	COG3135	benzoate transporter
I6L24_11815	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L24_11820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L24_11825	COG0183	Belongs to the thiolase family
I6L24_11830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L24_11860	COG0183	Belongs to the thiolase family
I6L24_11865	COG1960	acyl-CoA dehydrogenase activity
I6L24_11895	COG0789	Transcriptional regulator
I6L24_11905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L24_11910	COG0640	Transcriptional regulator
I6L24_11930	COG3122	Protein conserved in bacteria
I6L24_11935	COG0668	transmembrane transport
I6L24_11940	COG1132	(ABC) transporter
I6L24_11950	COG0509	glycine decarboxylation via glycine cleavage system
I6L24_11955	COG2814	Major facilitator Superfamily
I6L24_11980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L24_11990	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6L24_11995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L24_12050	COG1525	nuclease
I6L24_12060	COG1294	oxidase, subunit
I6L24_12065	COG1271	oxidase subunit
I6L24_12080	COG2169	Transcriptional regulator
I6L24_12085	COG1960	acyl-CoA dehydrogenase activity
I6L24_12090	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L24_12095	COG2207	Transcriptional regulator
I6L24_12100	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L24_12105	COG0730	response to heat
I6L24_12110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L24_12175	COG2826	transposase and inactivated derivatives, IS30 family
I6L24_12185	COG1960	acyl-CoA dehydrogenase activity
I6L24_12190	COG0456	acetyltransferase
I6L24_12225	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I6L24_12240	COG0552	protein localization to endoplasmic reticulum
I6L24_12245	COG0612	Peptidase, M16
I6L24_12275	COG0517	IMP dehydrogenase activity
I6L24_12280	COG0133	tryptophan synthase activity
I6L24_12290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L24_12310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6L24_12340	COG0537	adenosine 5'-monophosphoramidase activity
I6L24_12370	COG1294	oxidase, subunit
I6L24_12390	COG0772	Belongs to the SEDS family
I6L24_12405	COG0148	phosphopyruvate hydratase activity
I6L24_12435	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L24_12435	COG1902	pentaerythritol trinitrate reductase activity
I6L24_12450	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6L24_12455	COG0583	DNA-binding transcription factor activity
I6L24_12515	COG1570	exodeoxyribonuclease VII activity
I6L24_12555	COG0729	surface antigen
I6L24_12560	COG0477	Major facilitator Superfamily
I6L24_12595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L24_12605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L24_12610	COG1960	acyl-CoA dehydrogenase activity
I6L24_12630	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L24_12635	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6L24_12650	COG3335	DDE superfamily endonuclease
I6L24_12660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L24_12685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6L24_12690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6L24_12695	COG1845	cytochrome c oxidase, subunit III
I6L24_12700	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6L24_12710	COG0360	Binds together with S18 to 16S ribosomal RNA
I6L24_12725	COG0305	Participates in initiation and elongation during chromosome replication
I6L24_12730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L24_12745	COG1305	Transglutaminase-like
I6L24_12755	COG2308	Evidence 4 Homologs of previously reported genes of
I6L24_12765	COG0069	glutamate synthase activity
I6L24_12785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6L24_12790	COG1454	alcohol dehydrogenase
I6L24_12795	COG0824	Thioesterase
I6L24_12800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6L24_12810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L24_12825	COG0183	Belongs to the thiolase family
I6L24_12850	COG3335	DDE superfamily endonuclease
I6L24_12860	COG0583	DNA-binding transcription factor activity
I6L24_12865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L24_12875	COG3135	benzoate transporter
I6L24_12890	COG0589	response to stress
I6L24_12895	COG0589	response to stress
I6L24_12905	COG0308	aminopeptidase N
I6L24_12925	COG1253	flavin adenine dinucleotide binding
I6L24_12945	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L24_12950	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6L24_12965	COG2431	L-lysine efflux transmembrane transporter activity
I6L24_12985	COG0776	regulation of translation
I6L24_13015	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6L24_13045	COG1309	transcriptional regulator
I6L24_13050	COG0084	hydrolase, TatD family'
I6L24_13070	COG1663	tetraacyldisaccharide 4'-kinase activity
I6L24_13075	COG1132	(ABC) transporter
I6L24_13085	COG0811	peptide transport
I6L24_13090	COG1475	DNA binding
I6L24_13095	COG1192	Involved in chromosome partitioning
I6L24_13105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6L24_13110	COG3178	'Phosphotransferase
I6L24_13120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L24_13125	COG1923	regulation of RNA biosynthetic process
I6L24_13135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L24_13140	COG0802	atpase or kinase
I6L24_13175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L24_13195	COG1643	Atp-dependent helicase
I6L24_13220	COG3634	alkyl hydroperoxide reductase activity
I6L24_13250	COG1254	Belongs to the acylphosphatase family
I6L24_13255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6L24_13255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L24_13300	COG1401	restriction endodeoxyribonuclease activity
I6L24_13320	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6L24_13400	COG2233	PERMEase
I6L24_13415	COG0583	DNA-binding transcription factor activity
I6L24_13420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L24_13425	COG4266	Belongs to the allantoicase family
I6L24_13440	COG2233	PERMEase
I6L24_13445	COG2351	hydroxyisourate hydrolase activity
I6L24_13470	COG0804	urea catabolic process
I6L24_13485	COG0831	urea catabolic process
I6L24_13490	COG0829	nickel cation binding
I6L24_13505	COG0830	nickel cation binding
I6L24_13575	COG0204	Acyl-transferase
I6L24_13600	COG0012	GTP binding
I6L24_13605	COG3385	transposase activity
I6L24_13610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L24_13620	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6L24_13640	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6L24_13650	COG0386	Belongs to the glutathione peroxidase family
I6L24_13655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6L24_13660	COG0436	Aminotransferase
I6L24_13685	COG2351	hydroxyisourate hydrolase activity
I6L24_13705	COG1686	Belongs to the peptidase S11 family
I6L24_13710	COG1252	NADH dehydrogenase
I6L24_13730	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6L24_13745	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6L24_13760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L24_13765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6L24_13770	COG0527	aspartate kinase activity
I6L24_13780	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6L24_13800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L24_13805	COG2252	PERMEase
I6L24_13830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6L24_13835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6L24_13845	COG0693	protein deglycase activity
I6L24_13850	COG1960	acyl-CoA dehydrogenase activity
I6L24_13855	COG1301	dicarboxylic acid transport
I6L24_13865	COG3139	Protein of unknown function (DUF1315)
I6L24_13870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6L24_13875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L24_13885	COG0494	nUDIX hydrolase
I6L24_13895	COG0642	Histidine kinase
I6L24_13910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L24_13925	COG1720	tRNA m6t6A37 methyltransferase activity
I6L24_13955	COG0826	peptidase U32
I6L24_13960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L24_13965	COG3634	alkyl hydroperoxide reductase activity
I6L24_13985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L24_14020	COG3706	GGDEF domain
I6L24_14035	COG1131	(ABC) transporter
I6L24_14040	COG0842	Transport permease protein
I6L24_14055	COG2951	lytic endotransglycosylase activity
I6L24_14080	COG0052	Belongs to the universal ribosomal protein uS2 family
I6L24_14090	COG0436	Aminotransferase
I6L24_14120	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6L24_14135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6L24_14140	COG0571	ribonuclease III activity
I6L24_14150	COG0681	Belongs to the peptidase S26 family
I6L24_14165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L24_14185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L24_14195	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L24_14200	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L24_14215	COG4208	sulfate ABC transporter
I6L24_14220	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L24_14225	COG0583	DNA-binding transcription factor activity
I6L24_14245	COG0602	queuosine metabolic process
I6L24_14250	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6L24_14260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6L24_14265	COG2353	YceI-like domain
I6L24_14275	COG0583	DNA-binding transcription factor activity
I6L24_14280	COG1051	belongs to the nudix hydrolase family
I6L24_14280	COG1056	cytidyltransferase-related domain
I6L24_14290	COG0778	Nitroreductase
I6L24_14295	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
I6L24_14305	COG0583	DNA-binding transcription factor activity
I6L24_14325	COG0047	phosphoribosylformylglycinamidine synthase activity
I6L24_14325	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L24_14350	COG2255	four-way junction helicase activity
I6L24_14365	COG1473	amidohydrolase
I6L24_14370	COG0824	Thioesterase
I6L24_14390	COG0823	Involved in the tonB-independent uptake of proteins
I6L24_14410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L24_14440	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6L24_14445	COG0628	permease
I6L24_14450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6L24_14455	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L24_14460	COG2267	carboxylic ester hydrolase activity
I6L24_14475	COG0658	competence protein
I6L24_14475	COG2333	competence protein COMEC
I6L24_14480	COG1136	(ABC) transporter
I6L24_14500	COG1671	Belongs to the UPF0178 family
I6L24_14520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L24_14560	COG1280	lysine exporter protein (LysE YggA)
I6L24_14565	COG1522	sequence-specific DNA binding
I6L24_14575	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6L24_14590	COG0019	diaminopimelate decarboxylase activity
I6L24_14600	COG1113	amino acid transport
I6L24_14605	COG1115	amino acid carrier protein
I6L24_14645	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6L24_14650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6L24_14655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L24_14660	COG5001	Diguanylate cyclase
I6L24_14660	COG1716	ATPase activity
I6L24_14675	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6L24_14695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L24_14710	COG0037	tRNA processing
I6L24_14715	COG0739	heme binding
I6L24_14715	COG0741	lytic transglycosylase activity
I6L24_14715	COG1196	nuclear chromosome segregation
I6L24_14720	COG0501	Belongs to the peptidase M48B family
I6L24_14730	COG2239	Acts as a magnesium transporter
I6L24_14755	COG1253	flavin adenine dinucleotide binding
I6L24_14760	COG3293	Transposase
I6L24_14795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6L24_14805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L24_14835	COG0505	Belongs to the CarA family
I6L24_14840	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6L24_14850	COG3385	transposase activity
I6L24_14855	COG1309	transcriptional regulator
I6L24_14860	COG0251	oxidation-reduction process
I6L24_14865	COG0110	maltose O-acetyltransferase activity
I6L24_14875	COG2826	transposase and inactivated derivatives, IS30 family
I6L24_14895	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L24_14920	COG0564	pseudouridine synthase activity
I6L24_14930	COG0358	DNA primase activity
I6L24_14935	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6L24_14945	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6L24_14975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L24_14980	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6L24_15020	COG3385	transposase activity
I6L24_15030	COG0586	Pfam SNARE associated Golgi protein
I6L24_15060	COG0321	lipoyl(octanoyl) transferase activity
I6L24_15075	COG0531	amino acid
I6L24_15090	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6L24_15095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L24_15095	COG1648	precorrin-2 dehydrogenase activity
I6L24_15100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6L24_15110	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6L24_15120	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6L24_15135	COG0671	phosphoesterase, PA-phosphatase related
I6L24_15140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L24_15155	COG0393	Putative heavy-metal-binding
I6L24_15160	COG0393	Putative heavy-metal-binding
I6L24_15190	COG2203	Gaf domain
I6L24_15190	COG3706	GGDEF domain
I6L24_15190	COG4251	negative regulation of phosphorylation
I6L24_15190	COG5001	Diguanylate cyclase
I6L24_15200	COG1285	pathogenesis
I6L24_15205	COG4681	YaeQ
I6L24_15210	COG0523	cobalamin synthesis protein
I6L24_15235	COG2814	Major facilitator Superfamily
I6L24_15245	COG1607	acyl-coa hydrolase
I6L24_15280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L24_15285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6L24_15300	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6L24_15345	COG3293	Transposase
I6L24_15355	COG2130	NADP-dependent
I6L24_15360	COG1309	transcriptional regulator
I6L24_15370	COG1902	pentaerythritol trinitrate reductase activity
I6L24_15380	COG1979	alcohol dehydrogenase
I6L24_15395	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6L24_15410	COG3321	synthase
I6L24_15410	COG0604	alcohol dehydrogenase
I6L24_15415	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6L24_15420	COG0583	DNA-binding transcription factor activity
I6L24_15425	COG4221	oxidoreductase activity
I6L24_15505	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6L24_15530	COG2132	Multicopper oxidase
I6L24_15550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L24_15615	COG3293	Transposase
I6L24_15625	COG1192	Involved in chromosome partitioning
I6L24_15695	COG1454	alcohol dehydrogenase
I6L24_15745	COG3335	DDE superfamily endonuclease
I6L24_15760	COG2226	methyltransferase
I6L24_15760	COG2267	carboxylic ester hydrolase activity
I6L24_15775	COG4106	trans-aconitate 2-methyltransferase activity
I6L24_15785	COG0642	Histidine kinase
I6L24_15800	COG2186	Transcriptional regulator
I6L24_15810	COG4628	conserved protein (DUF2132)
I6L24_15855	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L24_15860	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6L24_15865	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L24_15870	COG3293	Transposase
I6L24_15875	COG0583	DNA-binding transcription factor activity
I6L24_15890	COG2801	Transposase and inactivated derivatives
I6L24_15895	COG3077	Addiction module antitoxin, RelB DinJ family
I6L24_15905	COG2801	Transposase and inactivated derivatives
I6L24_15930	COG1487	ribonuclease activity
I6L24_15960	COG0477	Major facilitator Superfamily
I6L24_15965	COG0697	spore germination
I6L24_15970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6L24_15975	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L24_16010	COG1192	Involved in chromosome partitioning
I6L24_16075	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6L24_16095	COG3451	type IV secretory pathway VirB4
I6L24_16255	COG0659	secondary active sulfate transmembrane transporter activity
I6L24_16265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6L24_16270	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L24_16315	COG0659	secondary active sulfate transmembrane transporter activity
I6L24_16325	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6L24_16330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L24_16410	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L24_16415	COG3657	addiction module killer protein