locus-tag class description BVG18_00015 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 BVG18_00015 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 BVG18_00035 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BVG18_00060 ENOG4107XZC Restriction modification system DNA (Specificity BVG18_00065 ENOG4105CVR type I restriction-modification system BVG18_00070 ENOG4107SCJ type I restriction enzyme EcoKI subunit R BVG18_00095 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BVG18_00110 ENOG4107BJW polysaccharide deacetylase BVG18_00120 ENOG4105CND Glycosyl transferase, family 2 BVG18_00125 ENOG4107BJW polysaccharide deacetylase BVG18_00175 ENOG41067QW Transcriptional regulator BVG18_00190 ENOG4108J1Q BVG18_00210 ENOG4105DFP Integrase BVG18_00215 ENOG4105DFP Integrase BVG18_00355 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BVG18_00365 ENOG4105CAR Terminase, large subunit BVG18_00520 ENOG4105F8C transglutaminase domain-containing protein BVG18_00530 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BVG18_00535 ENOG4105VCD cytoplasmic protein BVG18_00540 ENOG4105D22 carbon starvation protein BVG18_00545 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BVG18_00550 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BVG18_00565 ENOG4105VFB Binds the 23S rRNA (By similarity) BVG18_00570 ENOG4105DHU Bile acid BVG18_00585 ENOG4105DAN ATP-dependent protease BVG18_00590 ENOG4105M2J Glutaredoxin BVG18_00595 ENOG4105C8Y Acetylornithine aminotransferase BVG18_00600 ENOG4105CR8 Transcriptional regulator BVG18_00605 ENOG4108K5P (LipO)protein BVG18_00610 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) BVG18_00625 ENOG4105DZ1 carboxypeptidase BVG18_00630 ENOG4108Z0R Transferase BVG18_00645 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BVG18_00650 ENOG41075W9 High frequency lysogenization protein HflD homolog BVG18_00655 ENOG4107QTF adenylosuccinate lyase BVG18_00675 ENOG4105ERU peptidase BVG18_00680 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BVG18_00690 ENOG4105C8U phosphate abc transporter BVG18_00695 ENOG4105CVA phosphate BVG18_00700 ENOG4105DY8 decarboxylase BVG18_00705 ENOG4108JPW Aminotransferase BVG18_00715 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BVG18_00725 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BVG18_00735 ENOG4105KVH Transcriptional regulator BVG18_00750 ENOG4105DTR rard protein BVG18_00760 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BVG18_00795 ENOG4105E2B Taurine dioxygenase BVG18_00805 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BVG18_00810 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BVG18_00815 ENOG4105VNT transposase (IS4 family) protein BVG18_00820 ENOG4107QPN acyl-Coa dehydrogenase BVG18_00830 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BVG18_00835 ENOG4105C2W permease BVG18_00840 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) BVG18_00845 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) BVG18_00850 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BVG18_00855 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) BVG18_00860 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BVG18_00870 ENOG4105C0H protease BVG18_00875 ENOG4107QNR UPF0135 protein BVG18_00880 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BVG18_00920 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) BVG18_00935 ENOG4105C5F glutamine synthetase BVG18_00940 ENOG4105DDQ anthranilate synthase BVG18_00945 ENOG4107QYG anthranilate phosphoribosyltransferase BVG18_00960 ENOG4105EUJ GTP cyclohydrolase i BVG18_00975 ENOG4105BZU Histidine kinase BVG18_00990 ENOG4105NX3 Membrane BVG18_01005 ENOG4105C2I pirin domain protein BVG18_01020 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BVG18_01040 ENOG4105EKE dihydroorotase BVG18_01045 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) BVG18_01065 ENOG4108IQI permease BVG18_01110 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component BVG18_01115 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component BVG18_01120 ENOG4105E43 Extracellular solute-binding protein, family 5 BVG18_01125 ENOG4105E9H Lytic Murein transglycosylase BVG18_01125 ENOG4105E9H Lytic Murein transglycosylase BVG18_01130 ENOG4107RZZ dna polymerase iii epsilon subunit BVG18_01140 ENOG4105E09 nadh pyrophosphatase BVG18_01150 ENOG4105W4M Transport-associated protein BVG18_01160 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) BVG18_01165 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BVG18_01175 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BVG18_01180 ENOG4105D0A hydroxylase BVG18_01190 ENOG4105WG9 Conserved Protein BVG18_01195 ENOG4107RAQ aminopeptidase BVG18_01230 ENOG4105DRR Transcriptional regulator, GntR family BVG18_01250 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BVG18_01260 ENOG4107VAM peptidase, m28 BVG18_01270 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BVG18_01280 ENOG4105D82 Glutamate dehydrogenase BVG18_01285 ENOG4108R3D Electron transport complex BVG18_01290 ENOG4105CSM endonuclease III BVG18_01315 ENOG4105CJN penicillin-binding protein BVG18_01320 ENOG4106H78 methyltransferase BVG18_01345 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase BVG18_01380 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BVG18_01400 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BVG18_01430 ENOG4105K63 Thioredoxin BVG18_01440 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) BVG18_01445 ENOG4105C11 sulfate adenylyltransferase), subunit 2 BVG18_01465 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BVG18_01475 ENOG4107QN2 dihydrolipoyl dehydrogenase BVG18_01480 ENOG4105C7S Dehydrogenase BVG18_01485 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BVG18_01495 ENOG4105E33 succinate dehydrogenase BVG18_01505 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein BVG18_01510 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit BVG18_01540 ENOG4107YZX Universal stress protein BVG18_01560 ENOG4105EEQ Na H antiporter BVG18_01570 ENOG4105CGZ zinc metallopeptidase BVG18_01575 ENOG4105CKW Inner membrane protein yedI BVG18_01595 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BVG18_01600 ENOG4105VCQ rubredoxin BVG18_01605 ENOG4107QZF nitrite reductase NADPH large subunit BVG18_01610 ENOG4108JNI Alpha beta hydrolase BVG18_01615 ENOG4105C5Q Transcriptional regulator BVG18_01630 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase BVG18_01635 ENOG4107U91 Rhomboid family BVG18_01640 ENOG4105CV6 ABC transporter, permease BVG18_01645 ENOG4108I0Y (ABC) transporter BVG18_01650 ENOG4108UJV acyl-CoA thioesterase i BVG18_01705 ENOG4105CJ3 phosphate transporter BVG18_01710 ENOG4105C3R Methionine synthase BVG18_01720 ENOG4105WDY DNA (cytosine-5-)-methyltransferase BVG18_01725 ENOG4105CMT Dihydroxyacetone kinase BVG18_01730 ENOG4105CSV Glutaminase BVG18_01735 ENOG4105BZU Histidine kinase BVG18_01750 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BVG18_01795 ENOG4107VMU Membrane BVG18_01820 ENOG4105D78 K07001 NTE family protein BVG18_01835 ENOG4105CK7 Sodium proline symporter BVG18_01840 ENOG4105CTB Polyprenyl synthetase BVG18_01845 ENOG4105C7F AcnD-accessory protein PrpF BVG18_01850 ENOG4105C85 amino acid BVG18_01880 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein BVG18_01890 ENOG4105D8T Acyltransferase BVG18_01895 ENOG4105C03 ribonuclease BVG18_01900 ENOG4108Z03 MAF-like protein BVG18_01905 ENOG4105VQ7 Rod shape-determining protein MreD BVG18_01910 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BVG18_01915 ENOG4105DFF Rod shape-determining protein mreb BVG18_01920 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BVG18_01930 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BVG18_01995 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase BVG18_02000 ENOG4106UW1 Major Facilitator superfamily BVG18_02040 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BVG18_02045 ENOG4105D60 lipoprotein releasing system transmembrane protein BVG18_02050 ENOG4105DJY efflux transporter, rnd family, mfp subunit BVG18_02060 ENOG4105CSP Major Facilitator Superfamily BVG18_02070 ENOG4107R3N Filamentation induced by cAMP protein fic BVG18_02080 ENOG4107R3N Filamentation induced by cAMP protein fic BVG18_02085 ENOG4107XTP (EAL) domain protein BVG18_02135 ENOG4105M3Z response regulator BVG18_02165 ENOG4105DZR Type I site-specific deoxyribonuclease BVG18_02195 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) BVG18_02260 ENOG4105DFP Integrase BVG18_02270 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BVG18_02275 ENOG4108VUY thioesterase Superfamily protein BVG18_02280 ENOG4105D52 delta-aminolevulinic acid dehydratase BVG18_02285 ENOG4108DN8 FAD dependent oxidoreductase BVG18_02300 ENOG4107RH8 nuclease SbcCD subunit D BVG18_02305 ENOG4105EYH Exonuclease BVG18_02315 ENOG4105DFA alanine racemase domain protein BVG18_02320 ENOG4105CZX twitching motility protein BVG18_02325 ENOG4105CZX twitching motility protein BVG18_02330 ENOG41090R7 Ferric uptake BVG18_02355 ENOG4105E7A Glutamine amidotransferase BVG18_02360 ENOG4105CAS nag kinase BVG18_02365 ENOG4107QKV phosphomannomutase BVG18_02370 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BVG18_02375 ENOG4105C4R Atp-dependent dna helicase BVG18_02380 ENOG4108ZG0 Ompa motb domain protein BVG18_02385 ENOG4106HNH Acyl-transferase BVG18_02400 ENOG4107QMS site-determining protein BVG18_02415 ENOG4105CNU cell division protein FtsK BVG18_02420 ENOG4105C3M thioredoxin reductase BVG18_02425 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) BVG18_02435 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BVG18_02445 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BVG18_02460 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BVG18_02475 ENOG4108YXA Membrane BVG18_02485 ENOG4105M4H endoribonuclease L-psp BVG18_02500 ENOG4105EW9 transcriptional regulator AsnC family BVG18_02505 ENOG4109066 lysm domain bon superfamily protein BVG18_02510 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BVG18_02515 ENOG4105CHR reductase BVG18_02520 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BVG18_02525 ENOG4105VGS 50s ribosomal protein l32 BVG18_02530 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein BVG18_02535 ENOG4108BPE -transporting atpase BVG18_02540 ENOG4107RTD sua5 ycio yrdc ywlc family protein BVG18_02555 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BVG18_02560 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BVG18_02565 ENOG4105FE9 pseudouridine synthase BVG18_02585 ENOG4105DGW oligopeptidase A BVG18_02625 ENOG4108UWD Iron-storage protein BVG18_02630 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BVG18_02635 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BVG18_02645 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BVG18_02655 ENOG4105HF0 Membrane BVG18_02660 ENOG4108EKN Biotin protein ligase C terminal domain BVG18_02680 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY BVG18_02690 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) BVG18_02695 ENOG4108Z0R Transferase BVG18_02700 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein BVG18_02705 ENOG4105DZS Phenylacetate-CoA ligase BVG18_02710 ENOG4105CHU acetyl-coa acetyltransferase BVG18_02715 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BVG18_02720 ENOG4108UKI Enoyl-CoA hydratase BVG18_02725 ENOG4105E39 Enoyl-CoA hydratase BVG18_02730 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BVG18_02735 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit BVG18_02740 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit BVG18_02745 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit BVG18_02750 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit BVG18_02755 ENOG4105DXM phenylacetic acid degradation protein BVG18_02760 ENOG4105DNH Major Facilitator BVG18_02770 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BVG18_02780 ENOG4105DJV ribulose-phosphate 3-epimerase BVG18_02795 ENOG4108M3P Membrane BVG18_02815 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BVG18_02820 ENOG41072GX Peptidase M22 Glycoprotease BVG18_02825 ENOG4108Z0R Transferase BVG18_02830 ENOG4105P8F nudix hydrolase BVG18_02900 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BVG18_02905 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BVG18_02960 ENOG4108ZHJ Organic hydroperoxide resistance protein BVG18_02970 ENOG4107QHF type ii secretion system protein e BVG18_02990 ENOG4105C2M dna polymerase I BVG18_02995 ENOG4108VIA integral membrane protein BVG18_03000 ENOG4105II7 pyrroline-5-carboxylate reductase BVG18_03005 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BVG18_03015 ENOG4105C9X ppx gppa phosphatase BVG18_03025 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BVG18_03040 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BVG18_03045 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BVG18_03060 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BVG18_03070 ENOG4105W39 Membrane BVG18_03080 ENOG4105CYM Glutathione S-transferase BVG18_03095 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BVG18_03115 ENOG4105CEY Amp-dependent synthetase and ligase BVG18_03120 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BVG18_03135 ENOG4108WBT adenosyltransferase BVG18_03150 ENOG4105CNG UPF0061 protein BVG18_03160 ENOG4105E3W Two component transcriptional regulator (Winged helix family BVG18_03165 ENOG4105EB3 Histidine kinase BVG18_03175 ENOG4105CSU acyl-Coa dehydrogenase BVG18_03180 ENOG4105CSU acyl-Coa dehydrogenase BVG18_03190 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BVG18_03210 ENOG4105UGU tonB-dependent Receptor BVG18_03220 ENOG4105C9M aspartyl-trna synthetase BVG18_03260 ENOG4105CM2 brancheD-chain amino acid aminotransferase BVG18_03265 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) BVG18_03270 ENOG4105D7V transposase BVG18_03300 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BVG18_03305 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BVG18_03315 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BVG18_03320 ENOG4105DJ0 Poly(A) Polymerase BVG18_03325 ENOG4105KQC Competence protein BVG18_03330 ENOG4105DXN mazG family BVG18_03345 ENOG4105VNT transposase (IS4 family) protein BVG18_03355 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BVG18_03375 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) BVG18_03395 ENOG4105WVQ Fe-S assembly protein IscX BVG18_03435 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BVG18_03440 ENOG4108ZP8 Acetolactate synthase small subunit BVG18_03445 ENOG4105C7K acetolactate synthase BVG18_03475 ENOG4105DJY efflux transporter, rnd family, mfp subunit BVG18_03480 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BVG18_03485 ENOG4105ENJ RND efflux system, outer membrane lipoprotein BVG18_03495 ENOG4105CUZ uba thif-type nad fad binding protein BVG18_03505 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) BVG18_03510 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BVG18_03520 ENOG4105VW4 glutaredoxin 3 BVG18_03530 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BVG18_03535 ENOG4105F8V Hydrolase, tatD family BVG18_03550 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BVG18_03555 ENOG4105BZU Histidine kinase BVG18_03560 ENOG4105CN1 protease BVG18_03585 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BVG18_03590 ENOG4108DNC Involved in acetate metabolism (By similarity) BVG18_03600 ENOG4107GFK fumarate BVG18_03615 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BVG18_03625 ENOG4105D05 Receptor BVG18_03630 ENOG4108ESX Receptor BVG18_03640 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BVG18_03645 ENOG4105DWV Homoserine O-trans-acetylase BVG18_03650 ENOG4105DWV Homoserine O-trans-acetylase BVG18_03660 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BVG18_03720 ENOG4105QNF Outer membrane lipoprotein BVG18_03725 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BVG18_03765 ENOG4105CIY formyltetrahydrofolate deformylase BVG18_03770 ENOG41062JF Transcriptional regulator BVG18_03775 ENOG4107RGH Aldehyde dehydrogenase BVG18_03780 ENOG4105KDC 50s ribosomal protein l28 BVG18_03785 ENOG4105W0E 50S ribosomal protein L33 BVG18_03790 ENOG4105CKD glutathione-regulated potassium-efflux system protein BVG18_03810 ENOG4105C4R Atp-dependent dna helicase BVG18_03825 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BVG18_03845 ENOG41069P5 Protein slyX homolog BVG18_03850 ENOG4105C5H ABC transporter BVG18_03855 ENOG4105D1S lipid A biosynthesis BVG18_03915 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BVG18_03930 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BVG18_03965 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase BVG18_03985 ENOG4105CH6 catalase BVG18_03990 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BVG18_04010 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase BVG18_04015 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) BVG18_04020 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase BVG18_04035 ENOG4105FUY alpha subunit BVG18_04040 ENOG4108W5M transcriptional regulator BVG18_04050 ENOG4105EPF Outer membrane porin BVG18_04060 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) BVG18_04065 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) BVG18_04070 ENOG4105IKQ hydratase BVG18_04075 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BVG18_04080 ENOG4105EI2 Pseudouridine synthase BVG18_04090 ENOG4105C03 ribonuclease BVG18_04120 ENOG41067S9 phage shock protein C, PspC BVG18_04130 ENOG4105C8P )-transporter BVG18_04140 ENOG4105W87 Cbs domain BVG18_04155 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BVG18_04180 ENOG4105C5I Dehydrogenase BVG18_04205 ENOG4105BZ8 glutamate synthase BVG18_04215 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) BVG18_04225 ENOG4105C5X domain protein BVG18_04240 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BVG18_04250 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase BVG18_04255 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) BVG18_04260 ENOG4108JU5 Magnesium and cobalt efflux protein BVG18_04275 ENOG4108VAU general secretion pathway protein G BVG18_04280 ENOG4105D7Q type ii secretion system BVG18_04285 ENOG4105C25 Primosomal protein n' BVG18_04295 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BVG18_04305 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) BVG18_04310 ENOG4105Z2P Protein of unknown function (DUF465) BVG18_04315 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BVG18_04320 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BVG18_04325 ENOG4107QYX exodeoxyribonuclease v alpha BVG18_04330 ENOG4107QKA exodeoxyribonuclease V beta BVG18_04335 ENOG4105DSY exodeoxyribonuclease V, gamma BVG18_04345 ENOG4105CSR polyphosphate kinase 2 BVG18_04365 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BVG18_04385 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BVG18_04390 ENOG4105E0F Histidine kinase BVG18_04400 ENOG4105CYC Transferase BVG18_04405 ENOG4107ZXU DSBA oxidoreductase BVG18_04435 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BVG18_04445 ENOG4105EIF outer membrane protein W BVG18_04450 ENOG4105D3Y Na H antiporter BVG18_04470 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BVG18_04475 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BVG18_04480 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BVG18_04485 ENOG4108VZM 50s ribosomal protein L10 BVG18_04490 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BVG18_04500 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BVG18_04505 ENOG4105PM1 preprotein translocase subunit SecE BVG18_04515 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BVG18_04545 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BVG18_04555 ENOG4105GVR general secretion pathway protein D BVG18_04570 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS BVG18_04595 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BVG18_04600 ENOG4108NEV two component transcriptional regulator, LytTR family BVG18_04605 ENOG4108HRK Histidine kinase BVG18_04625 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BVG18_04640 ENOG4106H31 ATP-dependent protease ATP-binding subunit-like protein BVG18_04650 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BVG18_04655 ENOG4105CHU acetyl-coa acetyltransferase BVG18_04720 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BVG18_04760 ENOG4105CUV Homoserine Kinase BVG18_04795 ENOG4105DFH Transport of potassium into the cell (By similarity) BVG18_04820 ENOG4108QDE fad dependent oxidoreductase BVG18_04825 ENOG4105D3R alkyl hydroperoxide reductase BVG18_04830 ENOG4108UUM single-stranded DNA-binding protein BVG18_04835 ENOG4107RDB Major Facilitator BVG18_04845 ENOG4105DWF phosphomethylpyrimidine kinase BVG18_04855 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BVG18_04865 ENOG4105BZU Histidine kinase BVG18_04875 ENOG4105C94 Transporter BVG18_04885 ENOG4107QN1 sodium solute BVG18_04890 ENOG41062QD Membrane BVG18_04895 ENOG4105BZU Histidine kinase BVG18_04910 ENOG4108UZX fmn reductase BVG18_04915 ENOG4105FBW Monooxygenase BVG18_04920 ENOG4105CVP deoxyribo-dipyrimidine photolyase BVG18_04925 ENOG4107T8P acyl-Coa dehydrogenase BVG18_04930 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BVG18_04935 ENOG4105KAF membrAne BVG18_04940 ENOG4105D64 Mechanosensitive ion channel BVG18_04950 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase BVG18_04955 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BVG18_04980 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BVG18_04995 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BVG18_05015 ENOG4107QSN dihydrolipoamide acetyltransferase BVG18_05020 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) BVG18_05040 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BVG18_05045 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BVG18_05050 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) BVG18_05060 ENOG4105DFU Cell wall formation (By similarity) BVG18_05075 ENOG4105D7Z glutathione synthase BVG18_05090 ENOG4105E3B Multicopper oxidase BVG18_05105 ENOG4105VEQ Cold shock protein BVG18_05115 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BVG18_05120 ENOG4105CGK Exodeoxyribonuclease III BVG18_05140 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BVG18_05150 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) BVG18_05195 ENOG4108Z7F N-acetyltransferase BVG18_05210 ENOG4108IV0 ABC, transporter BVG18_05215 ENOG4105C0Z ABC transporter BVG18_05225 ENOG4105C32 Amino acid ABC transporter (Permease) BVG18_05230 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein BVG18_05235 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BVG18_05240 ENOG4105IPS esterase BVG18_05250 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) BVG18_05255 ENOG4105D9M gamma-glutamylcysteine synthetase BVG18_05270 ENOG4106BRA Membrane BVG18_05295 ENOG4105KHC sulfurtransferase BVG18_05320 ENOG4105VNT transposase (IS4 family) protein BVG18_05350 ENOG4105C09 Bile acid BVG18_05355 ENOG4108RWI nicotinamidase BVG18_05360 ENOG4108SC4 )-transporter BVG18_05365 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BVG18_05375 ENOG4105C8V SAICAR synthetase BVG18_05380 ENOG4105D1H recombination factor protein RarA BVG18_05385 ENOG4105BZU Histidine kinase BVG18_05390 ENOG4108ZZ3 UPF0260 protein BVG18_05400 ENOG4105CJR Integral membrane protein (MviN BVG18_05405 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase BVG18_05410 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BVG18_05420 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BVG18_05425 ENOG4105EJ2 Transcriptional regulator BVG18_05430 ENOG4108Z33 Thiol disulfide Interchange Protein BVG18_05435 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BVG18_05440 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BVG18_05445 ENOG4105UBK short-chain dehydrogenase reductase BVG18_05465 ENOG4107QZM n-acetylglutamate synthase BVG18_05470 ENOG4105GVF (ABC) transporter BVG18_05475 ENOG4105GVF (ABC) transporter BVG18_05480 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BVG18_05485 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BVG18_05490 ENOG4108VM9 ABC, transporter BVG18_05495 ENOG4108R86 Transcriptional regulator BVG18_05505 ENOG4105DTN riboflavin biosynthesis protein ribF BVG18_05510 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BVG18_05515 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BVG18_05520 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase BVG18_05555 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BVG18_05560 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BVG18_05565 ENOG4105CVE Lytic murein transglycosylase BVG18_05570 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BVG18_05575 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BVG18_05585 ENOG4105DFU Cell wall formation (By similarity) BVG18_05615 ENOG410830R acetyltransferase BVG18_05625 ENOG4105DU1 integral membrane protein, terc BVG18_05635 ENOG4107QUY Guanine deaminase BVG18_05640 ENOG4108UGV hypoxanthine phosphoribosyltransferase BVG18_05655 ENOG4105T95 Thiol disulfide interChange protein BVG18_05660 ENOG4108PCX Major Facilitator BVG18_05665 ENOG4105VNT transposase (IS4 family) protein BVG18_05675 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BVG18_05680 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BVG18_05685 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BVG18_05690 ENOG4105VG0 50S ribosomal protein l34 BVG18_05695 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BVG18_05700 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BVG18_05710 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BVG18_05715 ENOG4105E2A Dehydrogenase BVG18_05720 ENOG4105C5H ABC transporter BVG18_05725 ENOG4108821 RND type efflux pump BVG18_05730 ENOG4108821 RND type efflux pump BVG18_05735 ENOG4108821 RND type efflux pump BVG18_05755 ENOG4108HWY Beta-lactamase BVG18_05785 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BVG18_05805 ENOG4105D2S major facilitator superfamily BVG18_05810 ENOG4105D2S major facilitator superfamily BVG18_05835 ENOG4107RKG DJ-1/PfpI family BVG18_05850 ENOG4105C8J )-transporter BVG18_05860 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) BVG18_05865 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BVG18_05910 ENOG4105D7V transposase BVG18_05920 ENOG4105C01 Dihydroxy-acid dehydratase BVG18_05925 ENOG4105D7V transposase BVG18_05950 ENOG4105C2W permease BVG18_05965 ENOG4105D7V transposase BVG18_05975 ENOG4105DJY efflux transporter, rnd family, mfp subunit BVG18_05995 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BVG18_06010 ENOG4105DQ4 alcohol dehydrogenase BVG18_06015 ENOG4108R3E Dna-3-methyladenine glycosylase i BVG18_06025 ENOG4105FAA peptidase M23 BVG18_06030 ENOG4105CEN a g-specific adenine glycosylase BVG18_06045 ENOG4108V1T peptidylprolyl cis-trans isomerase BVG18_06050 ENOG4108V1T peptidylprolyl cis-trans isomerase BVG18_06055 ENOG4108MRJ BVG18_06060 ENOG4105D75 Capsular exopolysaccharide family BVG18_06070 ENOG4105DAY polysaccharide export protein BVG18_06080 ENOG4107QQG Dehydrogenase BVG18_06085 ENOG4107R5Z Oxidoreductase domain protein BVG18_06090 ENOG4105J5G Transferase hexapeptide repeat containing protein BVG18_06095 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BVG18_06100 ENOG4105C1B dTDP-glucose 4-6-dehydratase BVG18_06105 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BVG18_06115 ENOG4108UT6 Transferase hexapeptide repeat containing protein BVG18_06120 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BVG18_06130 ENOG4105K64 Glycosyl transferase, family 2 BVG18_06150 ENOG4105D3Q Sugar transferase BVG18_06155 ENOG4107WZ3 Transferase BVG18_06160 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BVG18_06170 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BVG18_06175 ENOG4105C6Y Udp-glucose 6-dehydrogenase BVG18_06185 ENOG4105CMR udp-glucose 4-epimerase BVG18_06195 ENOG4107QKV phosphomannomutase BVG18_06235 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BVG18_06245 ENOG4108ZAI phosphatidylglycerophosphatase a BVG18_06250 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BVG18_06260 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BVG18_06265 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BVG18_06280 ENOG4107R1I NAD-dependent malic enzyme BVG18_06285 ENOG4105VYA Uncharacterized conserved protein (DUF2132) BVG18_06310 ENOG4105DGI Alkaline phosphatase BVG18_06330 ENOG4105CGH 5'-nucleotidase BVG18_06340 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BVG18_06345 ENOG4105KT5 UmuD protein BVG18_06360 ENOG4105F9F transposase BVG18_06375 ENOG4105D82 Glutamate dehydrogenase BVG18_06380 ENOG4105C8Y Acetylornithine aminotransferase BVG18_06385 ENOG4105F4X arginine BVG18_06390 ENOG4105C26 Dehydrogenase BVG18_06395 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) BVG18_06405 ENOG4105C85 amino acid BVG18_06425 ENOG4105ZTP Protein of unknown function (DUF1376) BVG18_06470 ENOG4107QJE Chromosome Partitioning Protein BVG18_06485 ENOG4105DQR SNARE associated Golgi BVG18_06490 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BVG18_06495 ENOG4105BZU Histidine kinase BVG18_06500 ENOG4105BZU Histidine kinase BVG18_06505 ENOG4105EUB pirin domain protein BVG18_06510 ENOG4108RXX maleylacetoacetate isomerase BVG18_06515 ENOG4105BZU Histidine kinase BVG18_06520 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BVG18_06535 ENOG4107QJQ Mate efflux family protein BVG18_06540 ENOG4105CHM Aminotransferase BVG18_06565 ENOG4105EZR dyp-type peroxidase family protein BVG18_06570 ENOG410829K Lysine exporter protein (Lyse ygga) BVG18_06575 ENOG4105FAV ABC, transporter BVG18_06580 ENOG4105FDK ABC transporter BVG18_06605 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BVG18_06620 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BVG18_06630 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BVG18_06645 ENOG4105C26 Dehydrogenase BVG18_06650 ENOG4105EUB pirin domain protein BVG18_06660 ENOG4108V06 Glutathione peroxidase BVG18_06665 ENOG4105SX7 Transporter BVG18_06675 ENOG4105C79 DNA protecting protein DprA BVG18_06705 ENOG4105D94 Major Facilitator Superfamily BVG18_06710 ENOG4105CCT upf0313 protein BVG18_06725 ENOG4105CSH Transporter BVG18_06730 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BVG18_06760 ENOG4108URH decarboxylase BVG18_06765 ENOG4105EE5 Membrane protein terC BVG18_06775 ENOG4105EN6 Membrane BVG18_06780 ENOG41079KZ Major Facilitator Superfamily BVG18_06785 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BVG18_06790 ENOG4105CEY Amp-dependent synthetase and ligase BVG18_06805 ENOG4105F0N pyrophosphate phospho-hydrolase BVG18_06820 ENOG4105C0P Mg chelatase subunit ChlI BVG18_06835 ENOG4105BZU Histidine kinase BVG18_06845 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BVG18_06860 ENOG4105DQR SNARE associated Golgi BVG18_06880 ENOG4108M8S permease YjgP YjgQ family protein BVG18_06885 ENOG4108K5H permease YjgP YjgQ family protein BVG18_06890 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BVG18_06900 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BVG18_06905 ENOG4105BZU Histidine kinase BVG18_06915 ENOG41061WM D-Alanyl-D-Alanine BVG18_06925 ENOG4105D6E homoserine dehydrogenase BVG18_06930 ENOG4105T95 Thiol disulfide interChange protein BVG18_06935 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BVG18_06945 ENOG4105CE1 Ferrous iron transport protein b BVG18_06960 ENOG4105CNI cell division protein FtsW BVG18_06970 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) BVG18_06975 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters BVG18_06980 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) BVG18_06985 ENOG41087AY ADP-Ribose pyrophosphatase BVG18_07000 ENOG4105DFG type I secretion outer membrane protein BVG18_07005 ENOG4108UTW Plays a role in the regulation of phosphate uptake BVG18_07010 ENOG4105BZ1 (ABC) transporter BVG18_07020 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BVG18_07030 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BVG18_07035 ENOG4105NBK UPF0345 protein BVG18_07040 ENOG4105C2N RNA methyltransferase TrmH family group 3 BVG18_07050 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BVG18_07065 ENOG4107QHF type ii secretion system protein e BVG18_07075 ENOG4107EJC Preprotein translocase subunit SecG BVG18_07105 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BVG18_07110 ENOG4105CHV Transcription elongation factor NusA BVG18_07120 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BVG18_07125 ENOG4105KJM monovalent cation h antiporter subunit g BVG18_07130 ENOG4105W4C monovalent cation H antiporter subunit F BVG18_07135 ENOG4105SC1 monovalent cation H antiporter subunit E BVG18_07140 ENOG4107R4Z monovalent cation h antiporter subunit d BVG18_07145 ENOG4108ZE9 Monovalent cation H antiporter subunit C BVG18_07150 ENOG4105D65 subunit l BVG18_07165 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BVG18_07170 ENOG4105PDP Short chain dehydrogenase BVG18_07180 ENOG4105C5H ABC transporter BVG18_07200 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BVG18_07210 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BVG18_07215 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BVG18_07220 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BVG18_07230 ENOG4105CJN penicillin-binding protein BVG18_07235 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BVG18_07240 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) BVG18_07245 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BVG18_07250 ENOG4105DHI Methyltransferase BVG18_07255 ENOG4105VNT transposase (IS4 family) protein BVG18_07260 ENOG4108JQC penicillin-binding protein 1A BVG18_07285 ENOG4105E4G Type IV pilus BVG18_07305 ENOG4105CBC glutamate synthase BVG18_07310 ENOG4105BZ8 glutamate synthase BVG18_07315 ENOG4108V0P LemA family BVG18_07370 ENOG4105KHS type IV fimbrial pilin protein BVG18_07385 ENOG4105YWY BVG18_07390 ENOG4108YSG O-Antigen polymerase BVG18_07395 ENOG4108UQY Iron-storage protein BVG18_07405 ENOG4105W53 bacterioferritin-associated ferredoxin BVG18_07410 ENOG4105KME endoribonuclease L-psp BVG18_07415 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BVG18_07420 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) BVG18_07425 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BVG18_07435 ENOG4105X0D Fimbrial protein BVG18_07470 ENOG4105K5M 30s ribosomal protein S16 BVG18_07475 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BVG18_07485 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BVG18_07500 ENOG4107IFA Lipase (EC 3.1.1.3) BVG18_07505 ENOG4107IFA Lipase (EC 3.1.1.3) BVG18_07510 ENOG4107IFA Lipase (EC 3.1.1.3) BVG18_07515 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) BVG18_07520 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BVG18_07530 ENOG4105D7V transposase BVG18_07535 ENOG4105EJ9 Membrane BVG18_07565 ENOG4108JQ1 Dehydrogenase BVG18_07570 ENOG4105CQB FAD linked oxidase domain protein BVG18_07580 ENOG4107QF7 multi-drug BVG18_07585 ENOG4105VCH membrane BVG18_07590 ENOG4105EM2 membrane BVG18_07595 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BVG18_07600 ENOG4105IPI Membrane BVG18_07605 ENOG4107QJE Chromosome Partitioning Protein BVG18_07620 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BVG18_07635 ENOG4105WMR Protein CrcB homolog BVG18_07640 ENOG4105NRA 50s ribosomal protein l31 type b BVG18_07655 ENOG4107QI1 Mate efflux family protein BVG18_07665 ENOG4105CSA Coproporphyrinogen iii oxidase BVG18_07675 ENOG4105VEQ Cold shock protein BVG18_07680 ENOG4105CSU acyl-Coa dehydrogenase BVG18_07695 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) BVG18_07725 ENOG4105ECY inositol monophosphatase BVG18_07730 ENOG4105C1J atp-dependent rna helicase BVG18_07735 ENOG4105DHJ ABC, transporter BVG18_07740 ENOG4105CY3 ABC transporter, permease BVG18_07745 ENOG4107PE3 Mammalian cell entry related domain protein BVG18_07760 ENOG4107QUT magnesium and cobalt transport protein CorA BVG18_07765 ENOG4108URH decarboxylase BVG18_07775 ENOG4105MJ2 Competence protein BVG18_07780 ENOG4105CB5 ATP-dependent DNA helicase recG BVG18_07795 ENOG4105E55 glycerol-3-phosphate acyltransferase BVG18_07800 ENOG4105C29 acyl-CoA thioesterase BVG18_07820 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BVG18_07825 ENOG4105D7A ATP-binding protein BVG18_07830 ENOG4105C28 cystathionine BVG18_07835 ENOG41089BK Glutamine amido-transferase BVG18_07850 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BVG18_07855 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BVG18_07865 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BVG18_07905 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BVG18_07915 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BVG18_07920 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BVG18_07930 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BVG18_07945 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BVG18_07950 ENOG41067V7 50S ribosomal protein L36 BVG18_07955 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BVG18_07960 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BVG18_07965 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BVG18_07970 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BVG18_07975 ENOG4108ZT0 50S ribosomal protein l17 BVG18_07980 ENOG4105CT3 Monooxygenase BVG18_07985 ENOG4105C1G acyl-Coa dehydrogenase BVG18_08015 ENOG4105EMK carboxylate amino acid amine transporter BVG18_08025 ENOG4105VKU nucleicacid-binding protein BVG18_08030 ENOG4105DGW oligopeptidase A BVG18_08035 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BVG18_08075 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase BVG18_08095 ENOG4107S2Z UPF0761 membrane protein BVG18_08100 ENOG4105CS1 NAD(P)H quinone oxidoreductase BVG18_08160 ENOG4105C9A Phoh family BVG18_08165 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BVG18_08170 ENOG4105E4C Lytic transglycosylase catalytic BVG18_08210 ENOG4105D6S protein involved in catabolism of external DNA BVG18_08215 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BVG18_08230 ENOG4107QN2 dihydrolipoyl dehydrogenase BVG18_08245 ENOG4107QPB Beta-lactamase domain protein BVG18_08260 ENOG4105NAU thioesterase Superfamily protein BVG18_08290 ENOG4105K9H YciI-like protein BVG18_08300 ENOG4105DB7 PHP domain protein BVG18_08305 ENOG4105FFC UPF0187 protein BVG18_08310 ENOG4105W5Q DNA repair protein (RadC BVG18_08315 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BVG18_08325 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BVG18_08385 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BVG18_08490 ENOG4105WXW Antirepressor BVG18_08565 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BVG18_08570 ENOG4105W8H transhydrogenase (subunit alpha BVG18_08575 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BVG18_08585 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) BVG18_08600 ENOG4105BZU Histidine kinase BVG18_08605 ENOG4105C6T cysteine synthase BVG18_08620 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BVG18_08630 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BVG18_08635 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BVG18_08640 ENOG4105VIE preprotein translocase, subunit YajC BVG18_08655 ENOG4108V0P LemA family BVG18_08665 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BVG18_08675 ENOG4105E9K Isocitrate dehydrogenase BVG18_08695 ENOG4108ZX5 transcriptional regulator BVG18_08715 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BVG18_08735 ENOG4105D3R alkyl hydroperoxide reductase BVG18_08740 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BVG18_08750 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BVG18_08755 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BVG18_08790 ENOG4105KB2 stringent starvation protein b BVG18_08795 ENOG4107MKT Stringent starvation protein a BVG18_08800 ENOG4108UJD 30S ribosomal protein S9 BVG18_08805 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BVG18_08810 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) BVG18_08815 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BVG18_08820 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BVG18_08855 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BVG18_08865 ENOG4107RZC phospholipase d BVG18_08880 ENOG4105CSH Transporter BVG18_08885 ENOG4108UT2 hemolysin iii BVG18_08905 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BVG18_08910 ENOG4105CHU acetyl-coa acetyltransferase BVG18_08915 ENOG4108R6W Transcriptional regulator, ARAC family BVG18_08920 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BVG18_08925 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BVG18_08940 ENOG4105CHU acetyl-coa acetyltransferase BVG18_08945 ENOG4105X0D Fimbrial protein BVG18_08950 ENOG4108WHA ompa motb domain protein BVG18_08960 ENOG4108IQI permease BVG18_08970 ENOG4105C2W permease BVG18_08980 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BVG18_08990 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) BVG18_09000 ENOG4105TW1 Carbohydrate-selective porin OprB BVG18_09005 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BVG18_09025 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) BVG18_09030 ENOG4105E3B Multicopper oxidase BVG18_09035 ENOG4108I0Z Aconitate hydratase BVG18_09065 ENOG4105D3G Pseudouridine synthase BVG18_09085 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BVG18_09100 ENOG4105DSF transport protein BVG18_09110 ENOG4105DWF phosphomethylpyrimidine kinase BVG18_09115 ENOG4107XGZ Hydrolase BVG18_09125 ENOG4105KAF membrAne BVG18_09130 ENOG4105TW1 Carbohydrate-selective porin OprB BVG18_09135 ENOG4105DZG Dehydrogenase BVG18_09140 ENOG4105CHB tonB-dependent Receptor BVG18_09240 ENOG4105EYM Major Facilitator superfamily BVG18_09280 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BVG18_09290 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BVG18_09295 ENOG4107EXC regulatoR BVG18_09300 ENOG4105JJR Histidine kinase BVG18_09310 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BVG18_09325 ENOG4105GKE subunit e BVG18_09330 ENOG4107QIZ NADH dehydrogenase BVG18_09335 ENOG4108IEH NADH dehydrogenase subunit g BVG18_09345 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BVG18_09350 ENOG4107UFS subunit j BVG18_09355 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BVG18_09360 ENOG4105D65 subunit l BVG18_09365 ENOG4105C8S subunit m BVG18_09400 ENOG4105DUM transcriptional regulator, lysR family BVG18_09405 ENOG4105DP0 ferredoxin-NADP reductase BVG18_09445 ENOG4105CBX hi0933 family BVG18_09470 ENOG4105VNT transposase (IS4 family) protein BVG18_09480 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BVG18_09495 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BVG18_09505 ENOG4105D1F ATP-binding protein BVG18_09550 ENOG4105D0S secretion protein (HlyD BVG18_09560 ENOG4108UNF response regulator BVG18_09565 ENOG4105M3Z response regulator BVG18_09570 ENOG4108ZGA chew protein BVG18_09575 ENOG4105C8Q Methyl-accepting chemotaxis BVG18_09580 ENOG4105CBS Chea signal transduction histidine kinase BVG18_09605 ENOG4105WD1 Membrane BVG18_09665 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BVG18_09675 ENOG4105EM2 membrane BVG18_09680 ENOG4105C2C drug resistance transporter, Bcr CflA BVG18_09695 ENOG4105D6U Sodium Glutamate Symporter BVG18_09700 ENOG4105BZG amino acid carrier protein BVG18_09705 ENOG4105FGV Chromate BVG18_09710 ENOG4105D78 K07001 NTE family protein BVG18_09725 ENOG4105CZM Major Facilitator BVG18_09730 ENOG4108W5M transcriptional regulator BVG18_09750 ENOG4105CKI cobalamin synthesis protein BVG18_09755 ENOG4108VWS Yaeq family BVG18_09760 ENOG4105KT7 mgtC SapB transporter BVG18_09800 ENOG4105K8R UPF0145 protein BVG18_09805 ENOG4105K8R UPF0145 protein BVG18_09810 ENOG4105ENJ RND efflux system, outer membrane lipoprotein BVG18_09815 ENOG4105BZS acriflavin resistance protein BVG18_09820 ENOG4105C1P efflux transporter, rnd family, mfp subunit BVG18_09825 ENOG410841Q phosphoesterase PA-phosphatase related protein BVG18_09840 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BVG18_09850 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) BVG18_09860 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BVG18_09865 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BVG18_09870 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BVG18_09880 ENOG4105CUB amino acid BVG18_09895 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) BVG18_09900 ENOG4108Z43 UPF0250 protein BVG18_09905 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BVG18_09925 ENOG4107T5V SNARE associated Golgi BVG18_09950 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BVG18_09975 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BVG18_09980 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BVG18_10010 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) BVG18_10020 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BVG18_10025 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BVG18_10030 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BVG18_10035 ENOG4105C34 Pseudouridine synthase BVG18_10040 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BVG18_10060 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding BVG18_10080 ENOG4105EQK -acetyltransferase BVG18_10085 ENOG4108UQ8 endoribonuclease L-psp BVG18_10090 ENOG4108Q5F Tetr family transcriptional regulator BVG18_10100 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BVG18_10105 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BVG18_10125 ENOG4105HBR Rna-binding protein BVG18_10135 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BVG18_10145 ENOG4105EEI dihydropteroate synthase BVG18_10180 ENOG4105C37 (CBS) domain BVG18_10190 ENOG4107RET Isocitrate lyase BVG18_10195 ENOG4105BZS acriflavin resistance protein BVG18_10200 ENOG4105CJW magnesium transporter BVG18_10210 ENOG4105D0M Protease HtpX homolog BVG18_10215 ENOG4105E4C Lytic transglycosylase catalytic BVG18_10220 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) BVG18_10240 ENOG4108RRZ Transcription elongation factor GreB BVG18_10260 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) BVG18_10270 ENOG4105C6K Malic enzyme BVG18_10280 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BVG18_10285 ENOG4105SYT Methylenetetrahydrofolate reductase BVG18_10290 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) BVG18_10295 ENOG4105VNT transposase (IS4 family) protein BVG18_10325 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BVG18_10335 ENOG4105BZG amino acid carrier protein BVG18_10340 ENOG4105C85 amino acid BVG18_10350 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BVG18_10365 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BVG18_10375 ENOG4108YXU transcriptional regulator AsnC family BVG18_10380 ENOG4105N14 lysine exporter protein LysE YggA BVG18_10385 ENOG4105BZJ Electron transfer flavoprotein BVG18_10390 ENOG4105C10 Electron transfer flavoprotein BVG18_10400 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BVG18_10420 ENOG4107KET secretion protein, HlyD family BVG18_10440 ENOG4108UPT UPF0178 protein BVG18_10460 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BVG18_10465 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BVG18_10480 ENOG4108MUZ hydrolase BVG18_10485 ENOG4108V3E phosphoribosylglycinamide formyltransferase BVG18_10490 ENOG4105CXB phosphoribosylaminoimidazole synthetase BVG18_10495 ENOG4105C02 permease BVG18_10515 ENOG4105VNT transposase (IS4 family) protein BVG18_10550 ENOG4105KCK Peptidoglycan-associated lipoprotein BVG18_10555 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) BVG18_10565 ENOG4105M8F Biopolymer transport protein exbD tolR BVG18_10570 ENOG4105E02 MotA TolQ exbB proton channel BVG18_10575 ENOG4107YD3 Thioesterase BVG18_10585 ENOG4107SCA Formamidase (EC 3.5.1.49) BVG18_10595 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BVG18_10625 ENOG4108ETH Formylglycinamide ribotide synthetase BVG18_10685 ENOG4108YYC ycei family BVG18_10690 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BVG18_10700 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BVG18_10705 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BVG18_10725 ENOG4107R11 Transcriptional regulator BVG18_10730 ENOG4108IJ6 ABC transporter BVG18_10735 ENOG4105ECW sulfate abc transporter BVG18_10740 ENOG4108I5D sulfate abc transporter BVG18_10750 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BVG18_10755 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BVG18_10765 ENOG4105HHA aminodeoxychorismate lyase BVG18_10780 ENOG4108IYU L-aspartate oxidase BVG18_10785 ENOG4105C0H protease BVG18_10800 ENOG4105C3F Signal peptidase i BVG18_10810 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BVG18_10815 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BVG18_10825 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) BVG18_10830 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) BVG18_10835 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase BVG18_10860 ENOG4105CHM Aminotransferase BVG18_10865 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BVG18_10870 ENOG4105CE9 30S ribosomal protein S2 BVG18_10895 ENOG4105CVE Lytic murein transglycosylase BVG18_10910 ENOG4105E3A (ABC) transporter BVG18_10915 ENOG4105DA5 (ABC) transporter BVG18_11065 ENOG4105MEW serine threonine protein phosphatase BVG18_11160 ENOG4105XB7 anti-repressor protein BVG18_11235 ENOG4105NVB glycoside hydrolase, family 19 BVG18_11250 ENOG4105BZU Histidine kinase BVG18_11290 ENOG4105NXH GreA GreB family elongation factor BVG18_11310 ENOG4108JU3 Alkyl hydroperoxide reductase BVG18_11315 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding BVG18_11320 ENOG4105CFP Peptidase U32 BVG18_11325 ENOG4108Z6Z Transcriptional regulator BVG18_11345 ENOG4105DP0 ferredoxin-NADP reductase BVG18_11350 ENOG4108R96 Methyltransferase, YaeB family BVG18_11360 ENOG4107QHF type ii secretion system protein e BVG18_11370 ENOG4105XJC Two component transcriptional regulator (Winged helix family BVG18_11375 ENOG4105DHQ Histidine kinase BVG18_11385 ENOG4105M6F mutator MutT protein BVG18_11395 ENOG4105BZ4 penicillin-binding protein BVG18_11400 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BVG18_11405 ENOG4105VUT cytoplasmic protein BVG18_11415 ENOG4105CK2 sodium dicarboxylate symporter BVG18_11420 ENOG4105C1G acyl-Coa dehydrogenase BVG18_11425 ENOG4107R7Y intracellular protease Pfpi family BVG18_11430 ENOG4105CQC Prephenate dehydratase BVG18_11435 ENOG4105CIH Imidazole acetol-phosphate transaminase BVG18_11440 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BVG18_11465 ENOG4105C7N Xanthine uracil vitamin C permease BVG18_11470 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) BVG18_11490 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BVG18_11500 ENOG4105CFH Aspartokinase BVG18_11505 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BVG18_11510 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BVG18_11525 ENOG4108UMN azlc family BVG18_11530 ENOG4105EW9 transcriptional regulator AsnC family BVG18_11540 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BVG18_11555 ENOG4108YZY peptidylprolyl cis-trans isomerase BVG18_11560 ENOG4105CEP NADH dehydrogenase BVG18_11565 ENOG4105DZ1 carboxypeptidase BVG18_11575 ENOG4105VT2 5-hydroxyisourate hydrolase BVG18_11595 ENOG4108R99 pseudouridine synthase BVG18_11615 ENOG4105CHM Aminotransferase BVG18_11620 ENOG4105E0X reductase BVG18_11625 ENOG4108V06 Glutathione peroxidase BVG18_11635 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) BVG18_11650 ENOG4105ZED uncharacterized protein ygaH BVG18_11655 ENOG4108UMN azlc family BVG18_11665 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BVG18_11670 ENOG4105C3G gtp-binding protein BVG18_11695 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase BVG18_11705 ENOG4105DFP Integrase BVG18_11750 ENOG4105CVR type I restriction-modification system BVG18_11775 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 BVG18_11790 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit BVG18_11810 ENOG4105VW4 glutaredoxin 3 BVG18_11860 ENOG4105CYM Glutathione S-transferase BVG18_11865 ENOG4107RFB Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BVG18_11885 ENOG4105DC8 reductase BVG18_11910 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 BVG18_11925 ENOG4105MEW serine threonine protein phosphatase BVG18_11945 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BVG18_11950 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BVG18_11955 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) BVG18_11970 ENOG4105CCF Lysine exporter protein (Lyse ygga) BVG18_11985 ENOG4108JU3 Alkyl hydroperoxide reductase BVG18_12010 ENOG4105D3R alkyl hydroperoxide reductase BVG18_12015 ENOG4105CQ7 ATP-dependent helicase BVG18_12035 ENOG4107QUV Domain protein BVG18_12050 ENOG4105I08 Pseudouridine synthase BVG18_12070 ENOG4105K8N protein family UPF0079, ATPase BVG18_12075 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BVG18_12085 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BVG18_12090 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) BVG18_12095 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) BVG18_12100 ENOG4105EHM Aminoglycoside phosphotransferase BVG18_12105 ENOG4108S0S Nucleotidyl transferase BVG18_12115 ENOG4107QJE Chromosome Partitioning Protein BVG18_12120 ENOG4105FA0 parb-like partition protein BVG18_12135 ENOG4105BZ1 (ABC) transporter BVG18_12140 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) BVG18_12150 ENOG4107QRG dna polymerase iii BVG18_12160 ENOG4105F8V Hydrolase, tatD family BVG18_12165 ENOG4105R8C Transcriptional regulator BVG18_12185 ENOG4108RTD type II secretion system protein K BVG18_12195 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BVG18_12205 ENOG4108Z6B deaminase BVG18_12220 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BVG18_12225 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BVG18_12240 ENOG4105DWU Membrane BVG18_12245 ENOG4107RN6 Monooxygenase BVG18_12255 ENOG4105D6Z AFG1 family ATPase BVG18_12260 ENOG4107QP3 malate synthase g BVG18_12280 ENOG4105EE5 Membrane protein terC BVG18_12300 ENOG4105CD8 aminopeptidase N BVG18_12310 ENOG41081QV Universal stress protein BVG18_12315 ENOG41081QV Universal stress protein BVG18_12330 ENOG4105DKK Benzoate BVG18_12335 ENOG4108NIW Leucine export protein LeuE BVG18_12340 ENOG4107QV2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BVG18_12345 ENOG4105F52 Transcriptional regulator BVG18_12360 ENOG4105CHU acetyl-coa acetyltransferase BVG18_12365 ENOG4105CHR reductase BVG18_12385 ENOG4107QMP dna polymerase iii subunits gamma and tau BVG18_12395 ENOG4105C0A alcohol dehydrogenase BVG18_12400 ENOG4107ZCW Low molecular weight phosphotyrosine protein phosphatase BVG18_12420 ENOG4105CBC glutamate synthase BVG18_12455 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BVG18_12460 ENOG4105CDU Replicative dna helicase BVG18_12485 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) BVG18_12490 ENOG4105CCU oxidase (Subunit III) BVG18_12495 ENOG4105BZ9 Cytochrome C oxidase, subunit I BVG18_12500 ENOG4105E2S oxidase) subunit II BVG18_12525 ENOG4105DEN Luciferase family BVG18_12540 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BVG18_12545 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BVG18_12565 ENOG4105C1G acyl-Coa dehydrogenase BVG18_12580 ENOG4105D06 uba thif-type nad fad binding protein BVG18_12590 ENOG4105KRF dihydroneopterin aldolase BVG18_12615 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) BVG18_12620 ENOG4105CFU surface antigen BVG18_12655 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BVG18_12675 ENOG4107QIJ Aconitate hydratase 2 BVG18_12705 ENOG4105CWM branched-chain amino acid transport system II carrier protein BVG18_12710 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BVG18_12715 ENOG4105CC0 LysR family Transcriptional regulator BVG18_12720 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BVG18_12735 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BVG18_12770 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BVG18_12775 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) BVG18_12785 ENOG4105CNI cell division protein FtsW BVG18_12805 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BVG18_12810 ENOG4105C4M (Ubiquinol oxidase) subunit I BVG18_12825 ENOG4105K59 histidine triad (HIT) protein BVG18_12845 ENOG4105C28 cystathionine BVG18_12855 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BVG18_12885 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BVG18_12890 ENOG4105W87 Cbs domain BVG18_12925 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BVG18_12940 ENOG4108Q67 UPF0319 protein BVG18_12965 ENOG4105C1G acyl-Coa dehydrogenase BVG18_12990 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) BVG18_13030 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BVG18_13035 ENOG4107TSN permease BVG18_13040 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BVG18_13045 ENOG4105E7U AraC family transcriptional regulator BVG18_13050 ENOG4105EEF Alkane 1-monooxygenase BVG18_13055 ENOG4105CSU acyl-Coa dehydrogenase BVG18_13075 ENOG4105C4M (Ubiquinol oxidase) subunit I BVG18_13080 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BVG18_13110 ENOG4105C1G acyl-Coa dehydrogenase BVG18_13155 ENOG4107RZC phospholipase d BVG18_13170 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BVG18_13190 ENOG4105CZX twitching motility protein BVG18_13195 ENOG4105CZM Major Facilitator BVG18_13200 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BVG18_13205 ENOG4108ZX5 transcriptional regulator BVG18_13210 ENOG4105BZ1 (ABC) transporter BVG18_13215 ENOG4105CUY Mechanosensitive ion channel BVG18_13220 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme BVG18_13240 ENOG41080HT Transcriptional regulator, arsr family BVG18_13245 ENOG4105C6T cysteine synthase BVG18_13275 ENOG41062JF Transcriptional regulator BVG18_13280 ENOG4105CSU acyl-Coa dehydrogenase BVG18_13285 ENOG4105CHU acetyl-coa acetyltransferase BVG18_13305 ENOG4105F2Z 3-oxoadipate enol-lactonase BVG18_13310 ENOG4105CHU acetyl-coa acetyltransferase BVG18_13315 ENOG4107QNJ CoA-transferase subunit B BVG18_13320 ENOG4107QP7 CoA-transferase subunit A BVG18_13325 ENOG4105DKK Benzoate BVG18_13330 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase BVG18_13335 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein BVG18_13340 ENOG4108UKV benzoate 1,2-dioxygenase BVG18_13345 ENOG4105FUY alpha subunit BVG18_13355 ENOG4105NN7 muconolactone delta-isomerase BVG18_13360 ENOG4105DTQ mandelate racemase muconate lactonizing BVG18_13365 ENOG4108KB2 LysR family Transcriptional regulator BVG18_13370 ENOG4105D2S major facilitator superfamily BVG18_13380 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BVG18_13385 ENOG4105CEY Amp-dependent synthetase and ligase BVG18_13390 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BVG18_13405 ENOG4107YBY Hydrolase BVG18_13425 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BVG18_13440 ENOG4105MRR Transcriptional regulator (By similarity) BVG18_13450 ENOG4108HW3 (ABC) transporter BVG18_13475 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BVG18_13490 ENOG4107QZF nitrite reductase NADPH large subunit BVG18_13495 ENOG4108IFG nitrite reductase, (NAD(P)H) BVG18_13510 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BVG18_13520 ENOG4108ZAF Molybdopterin BVG18_13525 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BVG18_13530 ENOG4105CVM Molybdenum cofactor synthesis domain protein BVG18_13535 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BVG18_13540 ENOG4105E0C molybdate abc transporter BVG18_13545 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) BVG18_13550 ENOG4107RNU major facilitator superfamily MFS_1 BVG18_13555 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) BVG18_13560 ENOG4105TMB Formate nitrite transporter BVG18_13565 ENOG4107TPY serine threonine protein kinase BVG18_13575 ENOG4105DZ2 Transcriptional regulator BVG18_13590 ENOG4105C94 Transporter BVG18_13595 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) BVG18_13600 ENOG4105C26 Dehydrogenase BVG18_13615 ENOG4105DDY UPF0142 protein ycaO BVG18_13620 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase BVG18_13630 ENOG4105C1G acyl-Coa dehydrogenase BVG18_13635 ENOG4105C1G acyl-Coa dehydrogenase BVG18_13640 ENOG4107RGD Major Facilitator superfamily BVG18_13645 ENOG4107QP7 CoA-transferase subunit A BVG18_13650 ENOG4107QNJ CoA-transferase subunit B BVG18_13670 ENOG4107RGD Major Facilitator superfamily BVG18_13680 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BVG18_13685 ENOG4105CHU acetyl-coa acetyltransferase BVG18_13695 ENOG4105MP9 class II Aldolase BVG18_13705 ENOG4108UKI Enoyl-CoA hydratase BVG18_13710 ENOG4105EA8 2-Nitropropane dioxygenase BVG18_13715 ENOG4105CSU acyl-Coa dehydrogenase BVG18_13725 ENOG4107RN6 Monooxygenase BVG18_13730 ENOG4105CEY Amp-dependent synthetase and ligase BVG18_13735 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BVG18_13765 ENOG4105C26 Dehydrogenase BVG18_13770 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BVG18_13780 ENOG4105C1G acyl-Coa dehydrogenase BVG18_13785 ENOG4105E39 Enoyl-CoA hydratase BVG18_13795 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BVG18_13815 ENOG4108JPW Aminotransferase BVG18_13820 ENOG4105C26 Dehydrogenase BVG18_13850 ENOG4105VT2 5-hydroxyisourate hydrolase BVG18_13855 ENOG4105C2W permease BVG18_13870 ENOG4105DHG Allantoate amidinohydrolase BVG18_13875 ENOG41061H0 Monooxygenase BVG18_13880 ENOG4105SKE transcriptional Regulator LysR family BVG18_13905 ENOG4108JQ9 ABC transporter BVG18_13920 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BVG18_13930 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BVG18_13935 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) BVG18_13945 ENOG4105DIJ Phosphoethanolamine transferase BVG18_13950 ENOG4105XJC Two component transcriptional regulator (Winged helix family BVG18_13955 ENOG4105DHQ Histidine kinase BVG18_13965 ENOG41080IJ Diacylglycerol kinase BVG18_14055 ENOG4105CDV Ompa motb domain protein BVG18_14065 ENOG4105EV9 Alpha Beta Hydrolase BVG18_14070 ENOG4105F9F transposase BVG18_14100 ENOG4105CMR udp-glucose 4-epimerase BVG18_14105 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) BVG18_14135 ENOG4108Z66 YbaK ebsC protein BVG18_14140 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BVG18_14145 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein BVG18_14150 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BVG18_14170 ENOG4105D8G Major Facilitator superfamily BVG18_14235 ENOG4105BZN citrate synthase BVG18_14240 ENOG4105CR4 methylisocitrate lyase BVG18_14275 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BVG18_14280 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) BVG18_14300 ENOG4105E66 phosphoriboisomerase A BVG18_14305 ENOG4105C7B Threonine dehydratase BVG18_14315 ENOG4105CZN Potassium uptake protein BVG18_14320 ENOG4105HDD phospholipase BVG18_14345 ENOG4105PV3 Inner membrane protein yqiJ BVG18_14365 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BVG18_14370 ENOG4105K70 DNA-binding protein BVG18_14385 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family BVG18_14395 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins BVG18_14400 ENOG4108Z4V iron-sulfur cluster assembly BVG18_14415 ENOG4108ZIT Ferredoxin, 2FE-2S BVG18_14420 ENOG4105F8J Adenylate Guanylate cyclase BVG18_14435 ENOG4108JA2 transcriptioN-repair coupling factor BVG18_14445 ENOG4108IJ0 Aspartate ammonia-lyase BVG18_14450 ENOG4105CK7 Sodium proline symporter BVG18_14455 ENOG4105EW9 transcriptional regulator AsnC family BVG18_14480 ENOG4105FFC UPF0187 protein BVG18_14485 ENOG4105CX6 glutaminyL-tRNA synthetase BVG18_14525 ENOG4108RCM Nitroreductase BVG18_14535 ENOG4108TZV Membrane BVG18_14540 ENOG4105D2N Aldolase BVG18_14560 ENOG4108UHJ MAF-like protein BVG18_14565 ENOG4105EZE Cupin 4 family protein BVG18_14570 ENOG4105BZU Histidine kinase BVG18_14575 ENOG4105WH1 Two component transcriptional regulator luxr family BVG18_14585 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) BVG18_14590 ENOG4105K4T epimerase BVG18_14595 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BVG18_14605 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase BVG18_14610 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 BVG18_14615 ENOG4105VEJ Heat shock protein BVG18_14620 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BVG18_14625 ENOG4105Y3E Modulates RecA activity (By similarity) BVG18_14640 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BVG18_14645 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BVG18_14660 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BVG18_14665 ENOG4105DZP Membrane-associated zinc metalloprotease BVG18_14675 ENOG4105KNE Phosphatidate cytidylyltransferase BVG18_14680 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BVG18_14700 ENOG4105CUX Signal transduction histidine kinase BVG18_14705 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BVG18_14715 ENOG4108SC4 )-transporter BVG18_14750 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) BVG18_14755 ENOG4105DC1 bifunctional purine biosynthesis protein purh BVG18_14760 ENOG4105C12 Phosphoribosylglycinamide synthetase BVG18_14770 ENOG4108YYQ gCN5-related N-acetyltransferase BVG18_14780 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BVG18_14785 ENOG4108UMI ABC transporter, permease BVG18_14790 ENOG4105C0B DNA polymerase III (alpha subunit) BVG18_14820 ENOG4108Z4U Ferredoxin BVG18_14850 ENOG4105C42 Type I secretion membrane fusion protein (HlyD BVG18_14865 ENOG4108IUZ ABC transporter BVG18_14870 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA BVG18_14880 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase BVG18_14885 ENOG4105C2X Arabinose 5-phosphate isomerase BVG18_14915 ENOG4108SHQ Glutathione S-transferase BVG18_14920 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BVG18_14945 ENOG4105CV1 Transketolase (EC 2.2.1.1) BVG18_14960 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BVG18_14970 ENOG41066VF YeeE YedE family protein BVG18_14990 ENOG4105EA8 2-Nitropropane dioxygenase BVG18_15000 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BVG18_15005 ENOG4107QS8 (LipO)protein BVG18_15025 ENOG4105EJ2 Transcriptional regulator BVG18_15040 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) BVG18_15045 ENOG4105D3G Pseudouridine synthase BVG18_15070 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BVG18_15085 ENOG4105I7R Adenylate cyclase BVG18_15110 ENOG4105JAB phenazine biosynthesis protein, phzf family BVG18_15175 ENOG4106PBJ Serine threonine-protein kinase Pkn6 BVG18_15200 ENOG410620I Diguanylate cyclase BVG18_15210 ENOG4105VCC 30S ribosomal protein S21 BVG18_15215 ENOG4105KTH gatB Yqey BVG18_15225 ENOG4105ERG peptidase m48, ste24p BVG18_15240 ENOG4105D0M Protease HtpX homolog BVG18_15245 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase BVG18_15255 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) BVG18_15280 ENOG41069NU Nitroreductase BVG18_15290 ENOG4105C1J atp-dependent rna helicase BVG18_15305 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BVG18_15310 ENOG4105M08 Membrane BVG18_15325 ENOG4108K3A Glutathione S-transferase BVG18_15330 ENOG4105CHH sulfate transporter BVG18_15335 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BVG18_15355 ENOG4105CEY Amp-dependent synthetase and ligase BVG18_15360 ENOG4108SGK Tetr family transcriptional regulator BVG18_15365 ENOG4105C1G acyl-Coa dehydrogenase BVG18_15370 ENOG4107QX3 carboxylase BVG18_15375 ENOG4105E39 Enoyl-CoA hydratase BVG18_15395 ENOG4107QNJ CoA-transferase subunit B BVG18_15400 ENOG4105CRW Short chain fatty acid transporter BVG18_15410 ENOG4105CD3 dihydroorotase BVG18_15415 ENOG4105CXT aspartate transcarbamylase BVG18_15435 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BVG18_15445 ENOG4105CPC Aldo Keto reductase BVG18_15450 ENOG4107RYR Transcriptional regulator, Crp Fnr family BVG18_15455 ENOG4108UKZ OsmC family BVG18_15460 ENOG4107S1Q Phosphatase BVG18_15490 ENOG41080HT Transcriptional regulator, arsr family BVG18_15500 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase BVG18_15505 ENOG4107QX9 Thiol disulfide interChange protein BVG18_15520 ENOG4105DHQ Histidine kinase BVG18_15530 ENOG4105EYW Ion transport protein BVG18_15535 ENOG4105H3G oxidoreductase BVG18_15540 ENOG4105CAU Arsenical resistance protein, ArsH BVG18_15545 ENOG4105D6J arsenicaL-resistance protein BVG18_15555 ENOG4105KBH arsR family transcriptional regulator BVG18_15595 ENOG410620I Diguanylate cyclase BVG18_15605 ENOG4108R1E Serine threonine protein phosphatase 1 BVG18_15615 ENOG4105E5H Transposase BVG18_15670 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family BVG18_15695 ENOG4105CKD glutathione-regulated potassium-efflux system protein BVG18_15720 ENOG4105DM4 PTS System BVG18_15725 ENOG4105DE4 1-phosphofructokinase BVG18_15730 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BVG18_15745 ENOG41073TP transcriptional regulator BVG18_15750 ENOG4105DAA L-lactate BVG18_15765 ENOG4105DHQ Histidine kinase BVG18_15775 ENOG410825B Type 11 methyltransferase BVG18_15780 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BVG18_15790 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BVG18_15815 ENOG4105CNM Receptor BVG18_15840 ENOG4105C0A alcohol dehydrogenase BVG18_15850 ENOG4107RR1 TRANSCRIPTIONal BVG18_15865 ENOG4105E0K tonB-dependent siderophore receptor BVG18_15870 ENOG4105CUV Homoserine Kinase BVG18_15875 ENOG4105F9F transposase BVG18_15895 ENOG4105VNT transposase (IS4 family) protein BVG18_15915 ENOG4107QJE Chromosome Partitioning Protein BVG18_16115 ENOG4105HEI LysR family (Transcriptional regulator BVG18_16120 ENOG4105NF4 modulator of drug activity BVG18_16125 ENOG4105VRH Antibiotic biosynthesis monooxygenase BVG18_16130 ENOG4105YES addiction module antidote protein BVG18_16135 ENOG4105VUH addiction module killer protein BVG18_16295 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BVG18_16320 ENOG4105D0M Protease HtpX homolog BVG18_16395 ENOG4105CE1 Ferrous iron transport protein b BVG18_16415 ENOG4105DU1 integral membrane protein, terc BVG18_16435 ENOG41082YX Transcriptional regulator, arsr family BVG18_16440 ENOG4105E5H Transposase BVG18_16455 ENOG4105D6J arsenicaL-resistance protein BVG18_16460 ENOG4105CAU Arsenical resistance protein, ArsH BVG18_16465 ENOG4105YES addiction module antidote protein BVG18_16495 ENOG4105EMU Dehydrogenase BVG18_16500 ENOG4105EJC lysr family transcriptional regulator BVG18_16505 ENOG4107QPD alcohol dehydrogenase BVG18_16510 ENOG4108JA1 polyketide synthase BVG18_16525 ENOG4105C4W S-formylglutathione hydrolase BVG18_16540 ENOG4108I6A alcohol dehydrogenase BVG18_16550 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BVG18_16560 ENOG4108WUH Transcriptional regulator, TetR family BVG18_16565 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BVG18_16590 ENOG4105DWT malate dehydrogenase (quinone) BVG18_16610 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium BVG18_16640 ENOG4105WPN DNA integration recombination invertion protein BVG18_16660 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BVG18_16665 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) BVG18_16670 ENOG4105HF0 Membrane BVG18_16740 ENOG4105CHH sulfate transporter BVG18_16780 ENOG4105DWU Membrane BVG18_16860 ENOG4105QV4 Tryptophan halogenase BVG18_16865 ENOG4105CCF Lysine exporter protein (Lyse ygga) BVG18_17170 ENOG4105E5H Transposase BVG18_17210 ENOG4105E5H Transposase BVG18_17250 ENOG4105E5H Transposase BVG18_17300 ENOG4105E5H Transposase BVG18_17355 ENOG4105IYK transposase BVG18_17365 ENOG4105E5H Transposase BVG18_17395 ENOG4105E5H Transposase BVG18_17415 ENOG4105IYK transposase BVG18_17425 ENOG4105E5H Transposase BVG18_17430 ENOG4105IYK transposase BVG18_17440 ENOG4105E5H Transposase BVG18_17445 ENOG4105E5H Transposase BVG18_17475 ENOG4105E5H Transposase BVG18_17520 ENOG4105E5H Transposase BVG18_17535 ENOG4105E5H Transposase BVG18_17630 ENOG4105IYK transposase BVG18_17640 ENOG4105E5H Transposase BVG18_17650 ENOG4107F2M hemolysin-type calcium-binding region BVG18_17745 ENOG4105K4U addiction module toxin, RelE StbE family BVG18_17750 ENOG4105IYK transposase BVG18_17760 ENOG4105E5H Transposase BVG18_17790 ENOG4107QJE Chromosome Partitioning Protein BVG18_17855 ENOG4105E5H Transposase