locus-tag	class	description
DKE50_000060	COG0596	Alpha beta hydrolase
DKE50_000170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE50_000205	COG2814	Major facilitator Superfamily
DKE50_000210	COG0656	L-ascorbic acid biosynthetic process
DKE50_000235	COG1064	alcohol dehydrogenase
DKE50_000255	COG1194	a g-specific adenine glycosylase
DKE50_000270	COG5487	UPF0391 membrane protein
DKE50_000325	COG1335	isochorismatase
DKE50_000330	COG0385	Bile acid
DKE50_000335	COG0534	Mate efflux family protein
DKE50_000360	COG0625	glutathione transferase activity
DKE50_000435	COG0546	phosphoglycolate phosphatase activity
DKE50_000440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DKE50_000550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DKE50_000555	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DKE50_000665	COG0436	Aminotransferase
DKE50_000670	COG2733	membrane
DKE50_000815	COG2351	hydroxyisourate hydrolase activity
DKE50_000870	COG1393	Belongs to the ArsC family
DKE50_000875	COG0708	Exodeoxyribonuclease III
DKE50_000920	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DKE50_000965	COG2119	membrane
DKE50_000970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE50_000970	COG0426	domain, Protein
DKE50_001020	COG1519	Transferase
DKE50_001050	COG1522	sequence-specific DNA binding
DKE50_001080	COG3162	membrane
DKE50_001085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKE50_001115	COG1309	transcriptional regulator
DKE50_001270	COG0583	DNA-binding transcription factor activity
DKE50_001290	COG0667	Aldo Keto reductase
DKE50_001340	COG1733	regulation of RNA biosynthetic process
DKE50_001540	COG2329	Antibiotic biosynthesis monooxygenase
DKE50_001620	COG0745	RESPONSE REGULATOR receiver
DKE50_001630	COG0659	secondary active sulfate transmembrane transporter activity
DKE50_001765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DKE50_001780	COG2226	methyltransferase
DKE50_001835	COG0493	'glutamate synthase
DKE50_001845	COG1704	LemA family
DKE50_001950	COG0228	four-way junction DNA binding
DKE50_001955	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DKE50_001975	COG5380	lipid catabolic process
DKE50_002025	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DKE50_002030	COG2249	NAD(P)H dehydrogenase (quinone) activity
DKE50_002050	COG2032	superoxide dismutase activity
DKE50_002100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE50_002170	COG0752	glycyl-tRNA synthetase alpha subunit
DKE50_002250	COG1127	ABC transporter
DKE50_002255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DKE50_002285	COG0494	nUDIX hydrolase
DKE50_002290	COG1040	competence protein
DKE50_002315	COG1946	Acyl-CoA thioesterase
DKE50_002340	COG1017	nitric oxide dioxygenase activity
DKE50_002340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKE50_002470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DKE50_002480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DKE50_002515	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DKE50_002545	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DKE50_002600	COG0179	Fumarylacetoacetate (FAA) hydrolase
DKE50_002605	COG2207	Transcriptional regulator
DKE50_002695	COG1183	phosphatidylcholine synthase activity
DKE50_002810	COG2969	positive regulation of protein catabolic process
DKE50_002820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DKE50_002835	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DKE50_002860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DKE50_002935	COG3453	Protein conserved in bacteria
DKE50_002935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE50_002950	COG1607	acyl-coa hydrolase
DKE50_003000	COG3781	membrane
DKE50_003015	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DKE50_003025	COG1862	Preprotein translocase
DKE50_003270	COG0285	dihydrofolate synthase activity
DKE50_003385	COG0183	Belongs to the thiolase family
DKE50_003455	COG1902	pentaerythritol trinitrate reductase activity
DKE50_003490	COG2824	Alkylphosphonate utilization operon protein PhnA
DKE50_003705	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DKE50_003710	COG1077	Cell shape determining protein MreB Mrl
DKE50_003715	COG1792	Involved in formation and maintenance of cell shape
DKE50_003725	COG0424	maF-like protein
DKE50_003730	COG1530	ribonuclease E activity
DKE50_003760	COG2249	NAD(P)H dehydrogenase (quinone) activity
DKE50_003830	COG2816	NAD+ diphosphatase activity
DKE50_003850	COG2315	Protein conserved in bacteria
DKE50_003865	COG1752	Esterase of the alpha-beta hydrolase superfamily
DKE50_003945	COG1028	Short-chain dehydrogenase reductase Sdr
DKE50_003955	COG0393	Putative heavy-metal-binding
DKE50_003960	COG0393	Putative heavy-metal-binding
DKE50_004010	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DKE50_004030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DKE50_004045	COG0531	amino acid
DKE50_004065	COG2921	Belongs to the UPF0250 family
DKE50_004100	COG2009	succinate dehydrogenase
DKE50_004105	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DKE50_004160	COG2354	Protein conserved in bacteria
DKE50_004165	COG2321	neutral zinc metallopeptidase
DKE50_004275	COG0589	response to stress
DKE50_004290	COG1309	transcriptional regulator
DKE50_004305	COG0505	Belongs to the CarA family
DKE50_004520	COG2814	Major facilitator Superfamily
DKE50_004640	COG3811	Belongs to the UPF0386 family
DKE50_004735	COG0776	regulation of translation
DKE50_004760	COG0778	Nitroreductase
DKE50_004775	COG1929	Belongs to the glycerate kinase type-1 family
DKE50_004785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DKE50_004790	COG3339	Conserved Protein
DKE50_004845	COG1280	lysine exporter protein (LysE YggA)
DKE50_004955	COG1136	(ABC) transporter
DKE50_004980	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DKE50_005065	COG0824	Thioesterase
DKE50_005100	COG2814	Major facilitator Superfamily
DKE50_005115	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DKE50_005120	COG1024	Enoyl-CoA hydratase
DKE50_005160	COG0602	queuosine metabolic process
DKE50_005180	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DKE50_005190	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DKE50_005205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DKE50_005265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DKE50_005420	COG1215	transferase activity, transferring glycosyl groups
DKE50_005435	COG3293	Transposase
DKE50_005455	COG1252	NADH dehydrogenase
DKE50_005695	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DKE50_005700	COG1686	Belongs to the peptidase S11 family
DKE50_005770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DKE50_005825	COG1741	Belongs to the pirin family
DKE50_005935	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DKE50_005970	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DKE50_005975	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DKE50_006000	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DKE50_006005	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DKE50_006030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE50_006100	COG2951	lytic endotransglycosylase activity
DKE50_006130	COG0582	viral genome integration into host DNA
DKE50_006230	COG0305	Participates in initiation and elongation during chromosome replication
DKE50_006515	COG4160	amino acid transport
DKE50_006545	COG0384	phenazine biosynthesis protein PhzF
DKE50_006555	COG1720	tRNA m6t6A37 methyltransferase activity
DKE50_006570	COG3111	PFAM Bacterial OB fold (BOF) protein
DKE50_006575	COG0745	RESPONSE REGULATOR receiver
DKE50_006580	COG0642	Histidine kinase
DKE50_006590	COG0494	nUDIX hydrolase
DKE50_006605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DKE50_006610	COG3139	Protein of unknown function (DUF1315)
DKE50_006630	COG1960	acyl-CoA dehydrogenase activity
DKE50_006695	COG2363	Small membrane protein
DKE50_006710	COG1278	Cold shock
DKE50_006755	COG1286	toxin biosynthetic process
DKE50_006785	COG1610	YqeY-like protein
DKE50_006790	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DKE50_006905	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DKE50_006945	COG2801	Transposase and inactivated derivatives
DKE50_007010	COG2226	methyltransferase
DKE50_007050	COG1028	Short-chain dehydrogenase reductase Sdr
DKE50_007165	COG2995	paraquat-inducible protein a
DKE50_007180	COG2351	hydroxyisourate hydrolase activity
DKE50_007195	COG5002	protein histidine kinase activity
DKE50_007220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DKE50_007235	COG0642	Histidine kinase
DKE50_007240	COG0745	RESPONSE REGULATOR receiver
DKE50_007280	COG1301	dicarboxylic acid transport
DKE50_007325	COG0151	Belongs to the GarS family
DKE50_007335	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DKE50_007380	COG1305	Transglutaminase-like
DKE50_007420	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DKE50_007430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DKE50_007485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE50_007520	COG2890	protein-(glutamine-N5) methyltransferase activity
DKE50_007555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE50_007590	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DKE50_007695	COG3620	sequence-specific DNA binding
DKE50_008040	COG0802	atpase or kinase
DKE50_008055	COG1923	regulation of RNA biosynthetic process
DKE50_008090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKE50_008090	COG0519	Catalyzes the synthesis of GMP from XMP
DKE50_008105	COG0531	amino acid
DKE50_008140	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DKE50_008205	COG0625	glutathione transferase activity
DKE50_008220	COG1605	Chorismate mutase
DKE50_008290	COG0668	transmembrane transport
DKE50_008335	COG0488	(ABC) transporter
DKE50_008450	COG1454	alcohol dehydrogenase
DKE50_008475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DKE50_008565	COG1116	anion transmembrane transporter activity
DKE50_008565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DKE50_008570	COG0745	RESPONSE REGULATOR receiver
DKE50_008585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DKE50_008610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DKE50_008665	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DKE50_008670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DKE50_008775	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DKE50_008810	COG2137	regulation of response to DNA damage stimulus
DKE50_008875	COG0659	secondary active sulfate transmembrane transporter activity
DKE50_008880	COG0659	secondary active sulfate transmembrane transporter activity
DKE50_008890	COG3328	transposase activity
DKE50_008970	COG0583	DNA-binding transcription factor activity
DKE50_008985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE50_008990	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DKE50_008990	COG0517	IMP dehydrogenase activity
DKE50_009040	COG4890	Cyd operon protein YbgT
DKE50_009095	COG0569	domain protein
DKE50_009130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DKE50_009200	COG2323	membrane
DKE50_009210	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DKE50_009220	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DKE50_009245	COG2271	Major facilitator Superfamily
DKE50_009250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DKE50_009260	COG3485	protocatechuate 3,4-dioxygenase
DKE50_009290	COG2391	methyltransferase activity
DKE50_009310	COG0583	DNA-binding transcription factor activity
DKE50_009390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE50_009430	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DKE50_009445	COG4829	muconolactone delta-isomerase
DKE50_009465	COG2186	Transcriptional regulator
DKE50_009510	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DKE50_009560	COG1309	transcriptional regulator
DKE50_009640	COG1012	belongs to the aldehyde dehydrogenase family
DKE50_009670	COG2084	Dehydrogenase
DKE50_009685	COG1120	ATPase activity
DKE50_009705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DKE50_009770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DKE50_009815	COG4221	oxidoreductase activity
DKE50_009855	COG0745	RESPONSE REGULATOR receiver
DKE50_009905	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DKE50_009940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKE50_010020	COG3433	isochorismatase activity
DKE50_010020	COG1535	isochorismatase
DKE50_010085	COG4149	molybdate abc transporter
DKE50_010090	COG0725	ABC transporter, periplasmic molybdate-binding protein
DKE50_010105	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DKE50_010125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE50_010140	COG0412	Dienelactone hydrolase
DKE50_010220	COG0183	Belongs to the thiolase family
DKE50_010225	COG0583	DNA-binding transcription factor activity
DKE50_010325	COG0730	response to heat
DKE50_010355	COG1063	alcohol dehydrogenase
DKE50_010365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE50_010375	COG0022	dehydrogenase e1 component
DKE50_010380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DKE50_010385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE50_010400	COG3706	GGDEF domain
DKE50_010425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DKE50_010485	COG2226	methyltransferase
DKE50_010570	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKE50_010595	COG0730	response to heat
DKE50_010655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DKE50_010675	COG1960	acyl-CoA dehydrogenase activity
DKE50_010680	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DKE50_010685	COG2207	Transcriptional regulator
DKE50_010810	COG4172	Belongs to the ABC transporter superfamily
DKE50_010935	COG0590	tRNA wobble adenosine to inosine editing
DKE50_010980	COG0084	hydrolase, TatD family'
DKE50_011055	COG0191	fructose-bisphosphate aldolase activity
DKE50_011080	COG2850	peptidyl-arginine hydroxylation
DKE50_011090	COG0640	Transcriptional regulator
DKE50_011105	COG3122	Protein conserved in bacteria
DKE50_011110	COG1132	(ABC) transporter
DKE50_011130	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DKE50_011135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKE50_011150	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DKE50_011175	COG2353	YceI-like domain
DKE50_011255	COG3121	Chaperone
DKE50_011285	COG0697	spore germination
DKE50_011325	COG1309	transcriptional regulator
DKE50_011345	COG1522	sequence-specific DNA binding
DKE50_011410	COG2011	ABC-type metal ion transport system permease component
DKE50_011440	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DKE50_011575	COG1271	oxidase subunit
DKE50_011590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE50_011625	COG1346	cytolysis
DKE50_011635	COG0583	DNA-binding transcription factor activity
DKE50_011645	COG0625	glutathione transferase activity
DKE50_011650	COG0583	DNA-binding transcription factor activity
DKE50_011700	COG1126	abc transporter atp-binding protein
DKE50_011875	COG1309	transcriptional regulator
DKE50_011880	COG1960	acyl-CoA dehydrogenase activity
DKE50_011940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DKE50_011960	COG1024	Enoyl-CoA hydratase
DKE50_012015	COG1960	acyl-CoA dehydrogenase activity
DKE50_012075	COG0583	DNA-binding transcription factor activity
DKE50_012100	COG1073	alpha beta
DKE50_012115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DKE50_012160	COG0406	alpha-ribazole phosphatase activity
DKE50_012170	COG2050	protein possibly involved in aromatic compounds catabolism
DKE50_012180	COG3327	negative regulation of DNA-templated transcription, initiation
DKE50_012205	COG1024	Enoyl-CoA hydratase
DKE50_012225	COG3460	Phenylacetate-CoA oxygenase
DKE50_012230	COG3396	Phenylacetate-CoA oxygenase
DKE50_012240	COG1760	l-serine dehydratase
DKE50_012250	COG0789	Transcriptional regulator
DKE50_012265	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DKE50_012285	COG0590	tRNA wobble adenosine to inosine editing
DKE50_012290	COG0583	DNA-binding transcription factor activity
DKE50_012330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKE50_012340	COG0864	Transcriptional regulator
DKE50_012355	COG1733	regulation of RNA biosynthetic process
DKE50_012405	COG2801	Transposase and inactivated derivatives
DKE50_012455	COG1914	H( )-stimulated, divalent metal cation uptake system
DKE50_012480	COG3220	belongs to the UPF0276 family
DKE50_012505	COG3713	MltA-interacting MipA family protein
DKE50_012510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE50_012555	COG3501	Rhs element vgr protein
DKE50_012570	COG2801	Transposase and inactivated derivatives
DKE50_012645	COG1278	Cold shock
DKE50_012665	COG1522	sequence-specific DNA binding
DKE50_012740	COG1960	acyl-CoA dehydrogenase activity
DKE50_012750	COG1028	Short-chain dehydrogenase reductase Sdr
DKE50_012755	COG1028	Short-chain dehydrogenase reductase Sdr
DKE50_012775	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DKE50_012820	COG1137	ATPase activity
DKE50_012825	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DKE50_012840	COG0517	IMP dehydrogenase activity
DKE50_012840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DKE50_012910	COG1278	Cold shock
DKE50_013030	COG2871	sodium ion transport
DKE50_013050	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DKE50_013110	COG3634	alkyl hydroperoxide reductase activity
DKE50_013130	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DKE50_013135	COG0625	glutathione transferase activity
DKE50_013205	COG0667	Aldo Keto reductase
DKE50_013220	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DKE50_013335	COG3567	Phage-associated protein, HI1409 family
DKE50_013340	COG5410	chromosome segregation
DKE50_013440	COG1309	transcriptional regulator
DKE50_013530	COG1024	Enoyl-CoA hydratase
DKE50_013535	COG1012	belongs to the aldehyde dehydrogenase family
DKE50_013565	COG0697	spore germination
DKE50_013770	COG4239	(ABC) transporter, permease
DKE50_013940	COG3384	dioxygenase
DKE50_013990	COG0742	ribosomal rna small subunit methyltransferase
DKE50_014120	COG1773	rubredoxin
DKE50_014290	COG0242	peptide deformylase activity
DKE50_014350	COG1028	Short-chain dehydrogenase reductase Sdr
DKE50_014370	COG1414	Transcriptional regulator
DKE50_014395	COG1024	Enoyl-CoA hydratase
DKE50_014420	COG4681	YaeQ
DKE50_014440	COG1607	acyl-coa hydrolase
DKE50_014485	COG2040	homocysteine
DKE50_014670	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DKE50_014900	COG0420	3'-5' exonuclease activity
DKE50_014910	COG1968	undecaprenyl-diphosphatase activity
DKE50_014930	COG0735	belongs to the Fur family
DKE50_014935	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DKE50_014940	COG2914	Belongs to the UPF0125 (RnfH) family
DKE50_014980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DKE50_014990	COG0210	DNA helicase
DKE50_014995	COG2885	chlorophyll binding
DKE50_015055	COG0456	acetyltransferase
DKE50_015120	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DKE50_015120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DKE50_015140	COG1012	belongs to the aldehyde dehydrogenase family
DKE50_015195	COG0582	viral genome integration into host DNA
DKE50_015550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DKE50_015580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DKE50_015590	COG0352	thiamine-phosphate diphosphorylase activity
DKE50_015590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DKE50_015590	COG0351	phosphomethylpyrimidine kinase
DKE50_015620	COG1399	metal-binding, possibly nucleic acid-binding protein
DKE50_015625	COG3101	peptidyl-lysine hydroxylation
DKE50_015630	COG0009	L-threonylcarbamoyladenylate synthase
DKE50_015640	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DKE50_015680	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DKE50_015715	COG0730	response to heat
DKE50_015845	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DKE50_015880	COG0583	DNA-binding transcription factor activity
DKE50_015980	COG0745	RESPONSE REGULATOR receiver
DKE50_016035	COG0583	DNA-binding transcription factor activity
DKE50_016070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DKE50_016090	COG1063	alcohol dehydrogenase
DKE50_016390	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DKE50_016395	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DKE50_016430	COG0561	phosphatase activity
DKE50_016445	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DKE50_016515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DKE50_016580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DKE50_016590	COG1846	Transcriptional regulator
DKE50_016595	COG1764	response to oxidative stress
DKE50_016645	COG0248	Ppx GppA phosphatase
DKE50_016700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DKE50_016715	COG0625	glutathione transferase activity
DKE50_016740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE50_016770	COG1555	photosystem II stabilization
DKE50_016785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DKE50_016840	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DKE50_016890	COG0492	ferredoxin-NADP+ reductase activity
DKE50_016910	COG0640	Transcriptional regulator
DKE50_016935	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DKE50_017075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE50_017095	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DKE50_017105	COG0084	hydrolase, TatD family'
DKE50_017155	COG0440	acetolactate synthase activity
DKE50_017215	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DKE50_017230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DKE50_017250	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DKE50_017360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DKE50_017420	COG2813	Specifically methylates the guanine in position
DKE50_017420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKE50_017540	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DKE50_017600	COG1733	regulation of RNA biosynthetic process
DKE50_017610	COG2900	Belongs to the SlyX family
DKE50_017695	COG0473	3-isopropylmalate dehydrogenase activity
DKE50_017720	COG0583	DNA-binding transcription factor activity
DKE50_017765	COG0583	DNA-binding transcription factor activity
DKE50_017780	COG0625	glutathione transferase activity
DKE50_017785	COG2378	regulation of single-species biofilm formation
DKE50_017860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DKE50_017895	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DKE50_017940	COG4535	Mg2 and Co2 transporter CorC
DKE50_017950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DKE50_017985	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DKE50_018005	COG0598	Magnesium transport protein CorA
DKE50_018060	COG2226	methyltransferase
DKE50_018070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DKE50_018105	COG1006	Multisubunit Na H antiporter MnhC subunit
DKE50_018110	COG0651	ATP synthesis coupled electron transport
DKE50_018120	COG2212	antiporter activity
DKE50_018190	COG0237	dephospho-CoA kinase activity
DKE50_018200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DKE50_018225	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DKE50_018240	COG1289	transmembrane transporter activity
DKE50_018255	COG2169	Transcriptional regulator
DKE50_018255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DKE50_018260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DKE50_018370	COG0596	Alpha beta hydrolase
DKE50_018520	COG0181	hydroxymethylbilane synthase activity
DKE50_018555	COG0697	spore germination
DKE50_018585	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DKE50_018595	COG0772	Belongs to the SEDS family
DKE50_018620	COG4974	Belongs to the 'phage' integrase family
DKE50_018635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DKE50_018670	COG0795	lipopolysaccharide-transporting ATPase activity
DKE50_018795	COG0640	Transcriptional regulator
DKE50_018805	COG0789	Transcriptional regulator
DKE50_018860	COG0606	chelatase, subunit chli
DKE50_018870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE50_018875	COG0235	Class ii aldolase
DKE50_018925	COG2860	membrane
DKE50_018990	COG0655	NAD(P)H dehydrogenase (quinone) activity
DKE50_019040	COG1309	transcriptional regulator
DKE50_019115	COG0386	Belongs to the glutathione peroxidase family
DKE50_019240	COG0735	belongs to the Fur family
DKE50_019250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DKE50_019255	COG0519	Catalyzes the synthesis of GMP from XMP
DKE50_019255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKE50_019260	COG4399	Belongs to the UPF0754 family
DKE50_019330	COG3756	Protein conserved in bacteria
DKE50_019410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DKE50_019410	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE50_019415	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE50_019415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE50_019455	COG3916	Acyl-homoserine-lactone synthase
DKE50_019460	COG0477	Major facilitator Superfamily
DKE50_019465	COG1024	Enoyl-CoA hydratase
DKE50_019470	COG1024	Enoyl-CoA hydratase
DKE50_019485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DKE50_019515	COG1113	amino acid transport
DKE50_019520	COG0251	oxidation-reduction process
DKE50_019535	COG1522	sequence-specific DNA binding
DKE50_019560	COG0564	pseudouridine synthase activity
DKE50_019605	COG1802	Transcriptional regulator
DKE50_019630	COG2186	Transcriptional regulator
DKE50_019675	COG1216	Glycosyl transferase, family 2
DKE50_019770	COG3023	N-Acetylmuramoyl-L-alanine amidase
DKE50_019830	COG1028	Short-chain dehydrogenase reductase Sdr
DKE50_019860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE50_019865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE50_019880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DKE50_019945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DKE50_020000	COG2951	lytic endotransglycosylase activity
DKE50_020020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DKE50_020030	COG3328	transposase activity
DKE50_020055	COG0754	glutathionylspermidine amidase activity
DKE50_020115	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DKE50_020190	COG3118	belongs to the thioredoxin family
DKE50_020275	COG1192	Involved in chromosome partitioning
DKE50_020385	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
DKE50_020455	COG2801	Transposase and inactivated derivatives
DKE50_020545	COG1979	alcohol dehydrogenase
DKE50_020565	COG1309	transcriptional regulator
DKE50_020635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DKE50_020650	COG3316	Transposase and inactivated derivatives
DKE50_021005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DKE50_021095	COG3316	Transposase and inactivated derivatives
DKE50_021155	COG3316	Transposase and inactivated derivatives
DKE50_021215	COG3657	addiction module killer protein
DKE50_021220	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DKE50_021415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DKE50_021515	COG3316	Transposase and inactivated derivatives
DKE50_021580	COG3736	Type IV secretory pathway, component VirB8
DKE50_021600	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
DKE50_021670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone