locus-tag	class	description
I6L25_00010	COG2350	Protein conserved in bacteria
I6L25_00020	COG0613	PHP domain protein
I6L25_00025	COG3781	membrane
I6L25_00035	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L25_00040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L25_00050	COG1862	Preprotein translocase
I6L25_00080	COG2205	protein histidine kinase activity
I6L25_00080	COG2198	Histidine kinase
I6L25_00080	COG0784	Response regulator, receiver
I6L25_00080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L25_00085	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6L25_00100	COG2194	sulfuric ester hydrolase activity
I6L25_00110	COG0726	polysaccharide deacetylase
I6L25_00115	COG0463	Glycosyl transferase, family 2
I6L25_00120	COG0438	transferase activity, transferring glycosyl groups
I6L25_00185	COG1960	acyl-CoA dehydrogenase activity
I6L25_00190	COG1960	acyl-CoA dehydrogenase activity
I6L25_00200	COG2205	protein histidine kinase activity
I6L25_00205	COG0745	RESPONSE REGULATOR receiver
I6L25_00210	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6L25_00230	COG2096	Adenosyltransferase
I6L25_00285	COG0285	dihydrofolate synthase activity
I6L25_00305	COG0450	alkyl hydroperoxide reductase
I6L25_00320	COG0477	Major facilitator Superfamily
I6L25_00325	COG1272	protein, Hemolysin III
I6L25_00335	COG2153	protein acetylation
I6L25_00355	COG0183	Belongs to the thiolase family
I6L25_00360	COG2207	Transcriptional regulator
I6L25_00380	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L25_00400	COG0183	Belongs to the thiolase family
I6L25_00410	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6L25_00410	COG2885	chlorophyll binding
I6L25_00420	COG1690	Belongs to the RtcB family
I6L25_00425	COG0833	amino acid
I6L25_00435	COG2233	PERMEase
I6L25_00440	COG1217	gtp-binding protein TYPA
I6L25_00465	COG2094	Belongs to the DNA glycosylase MPG family
I6L25_00470	COG4772	TonB-dependent receptor
I6L25_00475	COG1902	pentaerythritol trinitrate reductase activity
I6L25_00490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L25_00495	COG0354	folic acid binding
I6L25_00505	COG3189	MarR family transcriptional regulator
I6L25_00510	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L25_00515	COG3422	double-strand break repair
I6L25_00590	COG2832	Protein of unknown function (DUF454)
I6L25_00595	COG1376	ErfK ybiS ycfS ynhG family protein
I6L25_00635	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L25_00645	COG1289	transmembrane transporter activity
I6L25_00650	COG2814	Major facilitator Superfamily
I6L25_00670	COG1115	amino acid carrier protein
I6L25_00675	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L25_00680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L25_00685	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6L25_00715	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6L25_00725	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6L25_00730	COG1077	Cell shape determining protein MreB Mrl
I6L25_00735	COG1792	Involved in formation and maintenance of cell shape
I6L25_00740	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6L25_00745	COG0424	maF-like protein
I6L25_00750	COG1530	ribonuclease E activity
I6L25_00760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L25_00805	COG2207	Transcriptional regulator
I6L25_00895	COG0582	viral genome integration into host DNA
I6L25_00915	COG3046	protein related to deoxyribodipyrimidine photolyase
I6L25_00920	COG2816	NAD+ diphosphatase activity
I6L25_00925	COG1113	amino acid transport
I6L25_00935	COG0142	geranyltranstransferase activity
I6L25_00940	COG2315	Protein conserved in bacteria
I6L25_00955	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L25_00975	COG2194	sulfuric ester hydrolase activity
I6L25_00980	COG0745	RESPONSE REGULATOR receiver
I6L25_00985	COG0642	Histidine kinase
I6L25_00995	COG0004	ammonium transporteR
I6L25_01000	COG0583	DNA-binding transcription factor activity
I6L25_01020	COG0525	valine-tRNA ligase activity
I6L25_01030	COG0525	valine-tRNA ligase activity
I6L25_01040	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_01050	COG0393	Putative heavy-metal-binding
I6L25_01055	COG0393	Putative heavy-metal-binding
I6L25_01060	COG1538	Outer membrane efflux protein
I6L25_01070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L25_01075	COG0671	phosphoesterase, PA-phosphatase related
I6L25_01105	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6L25_01120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L25_01120	COG1648	precorrin-2 dehydrogenase activity
I6L25_01125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6L25_01140	COG0531	amino acid
I6L25_01155	COG0321	lipoyl(octanoyl) transferase activity
I6L25_01160	COG2921	Belongs to the UPF0250 family
I6L25_01195	COG2009	succinate dehydrogenase
I6L25_01200	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6L25_01205	COG1053	succinate dehydrogenase
I6L25_01210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L25_01235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L25_01255	COG2354	Protein conserved in bacteria
I6L25_01260	COG2321	neutral zinc metallopeptidase
I6L25_01280	COG2843	Capsule synthesis protein
I6L25_01300	COG0589	response to stress
I6L25_01310	COG0251	oxidation-reduction process
I6L25_01315	COG1309	transcriptional regulator
I6L25_01330	COG0505	Belongs to the CarA family
I6L25_01355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L25_01360	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6L25_01410	COG0477	Major facilitator Superfamily
I6L25_01415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6L25_01430	COG1597	lipid kinase activity
I6L25_01435	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6L25_01455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L25_01460	COG0584	glycerophosphoryl diester phosphodiesterase
I6L25_01480	COG0741	lytic transglycosylase activity
I6L25_01500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L25_01515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L25_01540	COG1309	transcriptional regulator
I6L25_01545	COG1902	pentaerythritol trinitrate reductase activity
I6L25_01550	COG0596	Alpha beta hydrolase
I6L25_01550	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L25_01555	COG0596	Alpha beta hydrolase
I6L25_01560	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_01565	COG0778	Nitroreductase
I6L25_01570	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_01580	COG1929	Belongs to the glycerate kinase type-1 family
I6L25_01585	COG0243	molybdopterin cofactor binding
I6L25_01590	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6L25_01595	COG3339	Conserved Protein
I6L25_01605	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6L25_01620	COG1113	amino acid transport
I6L25_01625	COG1113	amino acid transport
I6L25_01635	COG0019	diaminopimelate decarboxylase activity
I6L25_01645	COG1280	lysine exporter protein (LysE YggA)
I6L25_01650	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6L25_01670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L25_01680	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6L25_01690	COG0463	Glycosyl transferase, family 2
I6L25_01710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L25_01745	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L25_01750	COG1136	(ABC) transporter
I6L25_01765	COG0616	signal peptide processing
I6L25_01765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L25_01770	COG0596	Alpha beta hydrolase
I6L25_01775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L25_01785	COG0628	permease
I6L25_01820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L25_01840	COG0823	Involved in the tonB-independent uptake of proteins
I6L25_01860	COG0824	Thioesterase
I6L25_01865	COG1473	amidohydrolase
I6L25_01885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L25_01885	COG0047	phosphoribosylformylglycinamidine synthase activity
I6L25_01890	COG2814	Major facilitator Superfamily
I6L25_01895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L25_01900	COG1024	Enoyl-CoA hydratase
I6L25_01905	COG1056	cytidyltransferase-related domain
I6L25_01905	COG1051	belongs to the nudix hydrolase family
I6L25_01920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6L25_01935	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6L25_01940	COG0602	queuosine metabolic process
I6L25_01950	COG4625	pathogenesis
I6L25_01955	COG0583	DNA-binding transcription factor activity
I6L25_01960	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L25_01965	COG4208	sulfate ABC transporter
I6L25_01970	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6L25_01980	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L25_01985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L25_01990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L25_02010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L25_02020	COG0481	GTPase activity
I6L25_02025	COG0681	Belongs to the peptidase S26 family
I6L25_02040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6L25_02050	COG1381	Involved in DNA repair and RecF pathway recombination
I6L25_02055	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6L25_02065	COG4221	oxidoreductase activity
I6L25_02095	COG0436	Aminotransferase
I6L25_02115	COG0556	nucleotide-excision repair
I6L25_02170	COG2070	2-Nitropropane dioxygenase
I6L25_02200	COG1215	transferase activity, transferring glycosyl groups
I6L25_02215	COG0415	Belongs to the DNA photolyase family
I6L25_02225	COG1252	NADH dehydrogenase
I6L25_02230	COG1686	Belongs to the peptidase S11 family
I6L25_02250	COG1187	pseudouridine synthase activity
I6L25_02275	COG0477	Major facilitator Superfamily
I6L25_02280	COG0583	DNA-binding transcription factor activity
I6L25_02285	COG1823	symporter activity
I6L25_02295	COG0612	Peptidase, M16
I6L25_02320	COG0352	thiamine-phosphate diphosphorylase activity
I6L25_02355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L25_02380	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L25_02385	COG0076	glutamate decarboxylase activity
I6L25_02395	COG1522	sequence-specific DNA binding
I6L25_02400	COG3961	Belongs to the TPP enzyme family
I6L25_02405	COG1113	amino acid transport
I6L25_02410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6L25_02415	COG0573	inorganic phosphate transmembrane transporter activity
I6L25_02425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L25_02430	COG0616	signal peptide processing
I6L25_02470	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L25_02475	COG1686	Belongs to the peptidase S11 family
I6L25_02500	COG0583	DNA-binding transcription factor activity
I6L25_02505	COG1067	ATP-dependent peptidase activity
I6L25_02530	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6L25_02545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6L25_02550	COG1966	Carbon starvation protein
I6L25_02555	COG2879	small protein
I6L25_02590	COG2964	Protein conserved in bacteria
I6L25_02595	COG1741	Belongs to the pirin family
I6L25_02610	COG3739	integral membrane protein
I6L25_02630	COG0302	gtp cyclohydrolase
I6L25_02640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L25_02650	COG2840	Smr protein MutS2
I6L25_02670	COG0308	aminopeptidase N
I6L25_02675	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L25_02690	COG0174	glutamine synthetase
I6L25_02700	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6L25_02735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L25_02740	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L25_02745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L25_02775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L25_02780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6L25_02785	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6L25_02800	COG1960	acyl-CoA dehydrogenase activity
I6L25_02805	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L25_02810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L25_02820	COG2223	nitrite transmembrane transporter activity
I6L25_02830	COG0024	Methionine aminopeptidase
I6L25_02835	COG0052	Belongs to the universal ribosomal protein uS2 family
I6L25_02850	COG2207	Transcriptional regulator
I6L25_02875	COG2951	lytic endotransglycosylase activity
I6L25_02880	COG0772	Belongs to the SEDS family
I6L25_02895	COG0842	Transport permease protein
I6L25_02900	COG1131	(ABC) transporter
I6L25_02990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L25_03005	COG4215	(ABC) transporter
I6L25_03010	COG4160	amino acid transport
I6L25_03015	COG4598	ABC transporter
I6L25_03025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L25_03030	COG0826	peptidase U32
I6L25_03035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L25_03040	COG0384	phenazine biosynthesis protein PhzF
I6L25_03050	COG1720	tRNA m6t6A37 methyltransferase activity
I6L25_03060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L25_03065	COG3111	PFAM Bacterial OB fold (BOF) protein
I6L25_03075	COG0642	Histidine kinase
I6L25_03085	COG0494	nUDIX hydrolase
I6L25_03095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L25_03100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6L25_03105	COG3139	Protein of unknown function (DUF1315)
I6L25_03110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L25_03115	COG1301	dicarboxylic acid transport
I6L25_03120	COG1960	acyl-CoA dehydrogenase activity
I6L25_03130	COG2801	Transposase and inactivated derivatives
I6L25_03135	COG2819	hydrolase of the alpha beta superfamily
I6L25_03145	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6L25_03155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L25_03160	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L25_03165	COG1234	tRNA 3'-trailer cleavage
I6L25_03190	COG2363	Small membrane protein
I6L25_03210	COG0513	Belongs to the DEAD box helicase family
I6L25_03220	COG0778	Nitroreductase
I6L25_03250	COG1286	toxin biosynthetic process
I6L25_03280	COG1610	YqeY-like protein
I6L25_03310	COG0515	serine threonine protein kinase
I6L25_03310	COG2815	serine threonine protein kinase
I6L25_03335	COG2831	hemolysin activation secretion protein
I6L25_03470	COG3111	PFAM Bacterial OB fold (BOF) protein
I6L25_03485	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6L25_03490	COG0786	glutamate:sodium symporter activity
I6L25_03495	COG0475	glutathione-regulated potassium exporter activity
I6L25_03495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L25_03500	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_03565	COG1073	alpha beta
I6L25_03570	COG1560	Kdo2-lipid A biosynthetic process
I6L25_03590	COG2995	paraquat-inducible protein a
I6L25_03595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L25_03595	COG3008	intermembrane lipid transfer
I6L25_03605	COG2351	hydroxyisourate hydrolase activity
I6L25_03620	COG5002	protein histidine kinase activity
I6L25_03645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L25_03655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L25_03660	COG0642	Histidine kinase
I6L25_03665	COG0745	RESPONSE REGULATOR receiver
I6L25_03705	COG1301	dicarboxylic acid transport
I6L25_03715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L25_03720	COG2011	ABC-type metal ion transport system permease component
I6L25_03725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L25_03730	COG1464	Belongs to the NlpA lipoprotein family
I6L25_03735	COG0151	Belongs to the GarS family
I6L25_03740	COG0138	bifunctional purine biosynthesis protein purh
I6L25_03745	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6L25_03780	COG2308	Evidence 4 Homologs of previously reported genes of
I6L25_03790	COG1305	Transglutaminase-like
I6L25_03800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L25_03805	COG0305	Participates in initiation and elongation during chromosome replication
I6L25_03830	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6L25_03840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6L25_03870	COG0726	polysaccharide deacetylase
I6L25_03870	COG1649	PFAM Uncharacterised BCR, COG1649
I6L25_03875	COG1215	transferase activity, transferring glycosyl groups
I6L25_03880	COG3658	cytochrome
I6L25_03890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L25_03905	COG0583	DNA-binding transcription factor activity
I6L25_03920	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L25_03925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L25_03930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L25_03945	COG1960	acyl-CoA dehydrogenase activity
I6L25_03950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L25_03955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L25_03980	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6L25_03985	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6L25_03990	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6L25_03995	COG2205	protein histidine kinase activity
I6L25_04000	COG0745	RESPONSE REGULATOR receiver
I6L25_04005	COG0174	glutamine synthetase
I6L25_04025	COG0729	surface antigen
I6L25_04055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L25_04060	COG2814	Major facilitator Superfamily
I6L25_04070	COG0583	DNA-binding transcription factor activity
I6L25_04085	COG1187	pseudouridine synthase activity
I6L25_04105	COG0802	atpase or kinase
I6L25_04110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L25_04120	COG1923	regulation of RNA biosynthetic process
I6L25_04125	COG0697	spore germination
I6L25_04155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L25_04155	COG0519	Catalyzes the synthesis of GMP from XMP
I6L25_04160	COG4302	ethanolamine ammonia-lyase activity
I6L25_04165	COG4303	Ethanolamine ammonia lyase large subunit
I6L25_04170	COG0531	amino acid
I6L25_04190	COG1454	alcohol dehydrogenase
I6L25_04195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L25_04205	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6L25_04225	COG0308	aminopeptidase N
I6L25_04250	COG0625	glutathione transferase activity
I6L25_04265	COG1605	Chorismate mutase
I6L25_04305	COG4264	IucA IucC family
I6L25_04315	COG4264	IucA IucC family
I6L25_04320	COG2423	ornithine cyclodeaminase activity
I6L25_04325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L25_04330	COG0668	transmembrane transport
I6L25_04375	COG0488	(ABC) transporter
I6L25_04380	COG0589	response to stress
I6L25_04395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6L25_04405	COG3135	benzoate transporter
I6L25_04410	COG1522	sequence-specific DNA binding
I6L25_04420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L25_04425	COG0583	DNA-binding transcription factor activity
I6L25_04435	COG0183	Belongs to the thiolase family
I6L25_04445	COG2030	dehydratase
I6L25_04450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L25_04475	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6L25_04490	COG0824	Thioesterase
I6L25_04495	COG1454	alcohol dehydrogenase
I6L25_04505	COG1335	isochorismatase
I6L25_04520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6L25_04550	COG0069	glutamate synthase activity
I6L25_04725	COG1484	DNA-dependent DNA replication
I6L25_04935	COG0592	DNA-directed DNA polymerase activity
I6L25_05025	COG2814	Major facilitator Superfamily
I6L25_05035	COG0439	Biotin carboxylase
I6L25_05040	COG0511	ligase activity, forming carbon-carbon bonds
I6L25_05055	COG1116	anion transmembrane transporter activity
I6L25_05055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L25_05060	COG0745	RESPONSE REGULATOR receiver
I6L25_05070	COG2146	nitrite reductase [NAD(P)H] activity
I6L25_05070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L25_05075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L25_05080	COG0243	molybdopterin cofactor binding
I6L25_05090	COG0243	molybdopterin cofactor binding
I6L25_05095	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6L25_05110	COG0315	cyclic pyranopterin monophosphate synthase activity
I6L25_05110	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L25_05115	COG0303	'Molybdopterin
I6L25_05125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L25_05130	COG0697	spore germination
I6L25_05150	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6L25_05155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L25_05210	COG2204	response regulator
I6L25_05215	COG3852	Histidine kinase
I6L25_05240	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L25_05245	COG0575	Belongs to the CDS family
I6L25_05280	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L25_05295	COG2137	regulation of response to DNA damage stimulus
I6L25_05305	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6L25_05310	COG1011	Hydrolase
I6L25_05330	COG1522	sequence-specific DNA binding
I6L25_05340	COG1113	amino acid transport
I6L25_05360	COG0659	secondary active sulfate transmembrane transporter activity
I6L25_05365	COG2135	peptidase activity
I6L25_05380	COG3300	MHYT domain
I6L25_05380	COG5001	Diguanylate cyclase
I6L25_05395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L25_05395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L25_05395	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6L25_05400	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L25_05405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L25_05405	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L25_05435	COG0024	Methionine aminopeptidase
I6L25_05440	COG0583	DNA-binding transcription factor activity
I6L25_05450	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6L25_05455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L25_05460	COG0517	IMP dehydrogenase activity
I6L25_05460	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L25_05485	COG0552	protein localization to endoplasmic reticulum
I6L25_05495	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I6L25_05510	COG4890	Cyd operon protein YbgT
I6L25_05515	COG1294	oxidase, subunit
I6L25_05530	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L25_05540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L25_05545	COG4774	siderophore transport
I6L25_05560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L25_05565	COG0569	domain protein
I6L25_05570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L25_05600	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6L25_05605	COG0542	response to heat
I6L25_05630	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L25_05630	COG1902	pentaerythritol trinitrate reductase activity
I6L25_05670	COG2323	membrane
I6L25_05680	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6L25_05690	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L25_05695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L25_05700	COG0183	Belongs to the thiolase family
I6L25_05705	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6L25_05710	COG0596	Alpha beta hydrolase
I6L25_05715	COG2271	Major facilitator Superfamily
I6L25_05720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L25_05725	COG3485	protocatechuate 3,4-dioxygenase
I6L25_05730	COG3485	protocatechuate 3,4-dioxygenase
I6L25_05735	COG0710	3-dehydroquinate dehydratase activity
I6L25_05740	COG3420	alginic acid biosynthetic process
I6L25_05745	COG3659	wide pore channel activity
I6L25_05750	COG4993	Dehydrogenase
I6L25_05760	COG2391	methyltransferase activity
I6L25_05775	COG1414	Transcriptional regulator
I6L25_05780	COG0583	DNA-binding transcription factor activity
I6L25_05785	COG1960	acyl-CoA dehydrogenase activity
I6L25_05810	COG2814	Major facilitator Superfamily
I6L25_05820	COG0154	amidase activity
I6L25_05840	COG4638	Rieske (2fe-2S)
I6L25_05850	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_05860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L25_05870	COG3733	amine oxidase
I6L25_05880	COG1012	belongs to the aldehyde dehydrogenase family
I6L25_05885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L25_05890	COG0183	Belongs to the thiolase family
I6L25_05895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L25_05900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L25_05910	COG4829	muconolactone delta-isomerase
I6L25_05915	COG4948	Mandelate Racemase Muconate Lactonizing
I6L25_05920	COG0583	DNA-binding transcription factor activity
I6L25_05930	COG2186	Transcriptional regulator
I6L25_05950	COG1012	belongs to the aldehyde dehydrogenase family
I6L25_05975	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6L25_05985	COG0789	Transcriptional regulator
I6L25_06000	COG1309	transcriptional regulator
I6L25_06010	COG1309	transcriptional regulator
I6L25_06050	COG2188	Transcriptional regulator
I6L25_06055	COG0583	DNA-binding transcription factor activity
I6L25_06090	COG1012	belongs to the aldehyde dehydrogenase family
I6L25_06095	COG0129	dihydroxy-acid dehydratase activity
I6L25_06105	COG0583	DNA-binding transcription factor activity
I6L25_06110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L25_06120	COG2084	Dehydrogenase
I6L25_06130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L25_06135	COG1120	ATPase activity
I6L25_06155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L25_06250	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6L25_06270	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6L25_06275	COG0210	DNA helicase
I6L25_06285	COG1064	alcohol dehydrogenase
I6L25_06290	COG4221	oxidoreductase activity
I6L25_06295	COG1073	alpha beta
I6L25_06315	COG1309	transcriptional regulator
I6L25_06325	COG2205	protein histidine kinase activity
I6L25_06330	COG0745	RESPONSE REGULATOR receiver
I6L25_06335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L25_06340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L25_06345	COG1538	Outer membrane efflux protein
I6L25_06350	COG2801	Transposase and inactivated derivatives
I6L25_06360	COG3539	Fimbrial protein
I6L25_06385	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6L25_06395	COG0753	catalase activity
I6L25_06410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L25_06475	COG4771	TonB-dependent receptor
I6L25_06480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L25_06485	COG3433	isochorismatase activity
I6L25_06485	COG1535	isochorismatase
I6L25_06490	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6L25_06495	COG1169	isochorismate synthase
I6L25_06500	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_06510	COG3251	PFAM MbtH domain protein
I6L25_06515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L25_06540	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6L25_06545	COG4149	molybdate abc transporter
I6L25_06550	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6L25_06560	COG4638	Rieske (2fe-2S)
I6L25_06565	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6L25_06570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L25_06570	COG0543	2 iron, 2 sulfur cluster binding
I6L25_06585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L25_06595	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_06610	COG2207	Transcriptional regulator
I6L25_06615	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_06620	COG2610	gluconate transmembrane transporter activity
I6L25_06625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L25_06660	COG0583	DNA-binding transcription factor activity
I6L25_06675	COG2031	fatty acid transporter
I6L25_06680	COG0183	Belongs to the thiolase family
I6L25_06685	COG0583	DNA-binding transcription factor activity
I6L25_06690	COG0583	DNA-binding transcription factor activity
I6L25_06705	COG1027	Aspartate ammonia-lyase
I6L25_06715	COG0477	Major facilitator Superfamily
I6L25_06735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L25_06740	COG4521	taurine ABC transporter
I6L25_06755	COG2188	Transcriptional regulator
I6L25_06765	COG2207	Transcriptional regulator
I6L25_06765	COG3708	Transcriptional regulator
I6L25_06780	COG0730	response to heat
I6L25_06790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L25_06790	COG3453	Protein conserved in bacteria
I6L25_06800	COG3781	membrane
I6L25_06805	COG1063	alcohol dehydrogenase
I6L25_06815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L25_06820	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L25_06825	COG0022	dehydrogenase e1 component
I6L25_06830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6L25_06835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L25_06865	COG0133	tryptophan synthase activity
I6L25_06875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L25_06910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6L25_06935	COG2226	methyltransferase
I6L25_06990	COG0842	Transport permease protein
I6L25_06995	COG0842	Transport permease protein
I6L25_07000	COG1131	(ABC) transporter
I6L25_07020	COG1238	metal cluster binding
I6L25_07025	COG2814	Major facilitator Superfamily
I6L25_07065	COG1937	Protein conserved in bacteria
I6L25_07070	COG1230	cation diffusion facilitator family transporter
I6L25_07115	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L25_07120	COG4773	Receptor
I6L25_07140	COG0730	response to heat
I6L25_07145	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L25_07155	COG4772	TonB-dependent receptor
I6L25_07170	COG0406	alpha-ribazole phosphatase activity
I6L25_07175	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6L25_07190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L25_07195	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6L25_07210	COG1960	acyl-CoA dehydrogenase activity
I6L25_07215	COG1960	acyl-CoA dehydrogenase activity
I6L25_07220	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L25_07225	COG2207	Transcriptional regulator
I6L25_07230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L25_07235	COG0776	regulation of translation
I6L25_07260	COG0822	iron-sulfur transferase activity
I6L25_07265	COG0316	Belongs to the HesB IscA family
I6L25_07295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L25_07315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L25_07320	COG0702	epimerase
I6L25_07350	COG4172	Belongs to the ABC transporter superfamily
I6L25_07355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L25_07360	COG0601	transmembrane transport
I6L25_07365	COG0339	signal peptide processing
I6L25_07390	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6L25_07415	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L25_07420	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6L25_07435	COG2431	L-lysine efflux transmembrane transporter activity
I6L25_07450	COG0776	regulation of translation
I6L25_07515	COG0084	hydrolase, TatD family'
I6L25_07535	COG1663	tetraacyldisaccharide 4'-kinase activity
I6L25_07540	COG1132	(ABC) transporter
I6L25_07550	COG0811	peptide transport
I6L25_07555	COG1475	DNA binding
I6L25_07560	COG1192	Involved in chromosome partitioning
I6L25_07570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6L25_07585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L25_07590	COG0191	fructose-bisphosphate aldolase activity
I6L25_07610	COG0424	maF-like protein
I6L25_07615	COG2850	peptidyl-arginine hydroxylation
I6L25_07625	COG0640	Transcriptional regulator
I6L25_07635	COG3619	membrane
I6L25_07640	COG3122	Protein conserved in bacteria
I6L25_07645	COG1132	(ABC) transporter
I6L25_07665	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6L25_07670	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L25_07680	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L25_07680	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L25_07680	COG0506	proline dehydrogenase activity
I6L25_07685	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6L25_07700	COG3698	Phosphodiester glycosidase
I6L25_07710	COG2353	YceI-like domain
I6L25_07720	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L25_07760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L25_07760	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6L25_07785	COG3539	Fimbrial protein
I6L25_07790	COG3121	Chaperone
I6L25_07815	COG0697	spore germination
I6L25_07825	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6L25_07835	COG0583	DNA-binding transcription factor activity
I6L25_07855	COG1309	transcriptional regulator
I6L25_07870	COG1522	sequence-specific DNA binding
I6L25_07880	COG1126	abc transporter atp-binding protein
I6L25_07885	COG0765	amino acid transport
I6L25_07890	COG0765	amino acid transport
I6L25_07920	COG1464	Belongs to the NlpA lipoprotein family
I6L25_07925	COG1464	Belongs to the NlpA lipoprotein family
I6L25_07930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L25_07935	COG2011	ABC-type metal ion transport system permease component
I6L25_07940	COG0012	GTP binding
I6L25_07965	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6L25_07995	COG1280	lysine exporter protein (LysE YggA)
I6L25_08005	COG0386	Belongs to the glutathione peroxidase family
I6L25_08015	COG0436	Aminotransferase
I6L25_08020	COG1301	dicarboxylic acid transport
I6L25_08055	COG3634	alkyl hydroperoxide reductase activity
I6L25_08070	COG0583	DNA-binding transcription factor activity
I6L25_08075	COG0798	PFAM Bile acid sodium symporter
I6L25_08080	COG0640	Transcriptional regulator
I6L25_08095	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6L25_08105	COG0583	DNA-binding transcription factor activity
I6L25_08115	COG1953	Uracil, thiamine, allantoin
I6L25_08125	COG2175	clavaminate synthase activity
I6L25_08130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L25_08135	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6L25_08140	COG4521	taurine ABC transporter
I6L25_08150	COG0477	Major facilitator Superfamily
I6L25_08170	COG1271	oxidase subunit
I6L25_08175	COG1294	oxidase, subunit
I6L25_08185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L25_08205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6L25_08225	COG3052	prosthetic group binding
I6L25_08230	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6L25_08240	COG2814	Major facilitator Superfamily
I6L25_08260	COG1346	cytolysis
I6L25_08270	COG0583	DNA-binding transcription factor activity
I6L25_08275	COG0625	glutathione transferase activity
I6L25_08280	COG0625	glutathione transferase activity
I6L25_08285	COG0583	DNA-binding transcription factor activity
I6L25_08300	COG1045	serine acetyltransferase
I6L25_08305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L25_08310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6L25_08320	COG1280	lysine exporter protein (LysE YggA)
I6L25_08335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L25_08340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L25_08345	COG1126	abc transporter atp-binding protein
I6L25_08350	COG0765	amino acid transport
I6L25_08355	COG0765	amino acid transport
I6L25_08375	COG0784	Response regulator, receiver
I6L25_08375	COG2205	protein histidine kinase activity
I6L25_08415	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_08465	COG0583	DNA-binding transcription factor activity
I6L25_08485	COG0318	PFAM AMP-dependent synthetase and ligase
I6L25_08490	COG1309	transcriptional regulator
I6L25_08495	COG1960	acyl-CoA dehydrogenase activity
I6L25_08500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L25_08505	COG1024	Enoyl-CoA hydratase
I6L25_08510	COG4770	biotin carboxylase activity
I6L25_08520	COG0583	DNA-binding transcription factor activity
I6L25_08535	COG1960	acyl-CoA dehydrogenase activity
I6L25_08555	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L25_08560	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L25_08565	COG2814	Major facilitator Superfamily
I6L25_08570	COG1960	acyl-CoA dehydrogenase activity
I6L25_08575	COG1024	Enoyl-CoA hydratase
I6L25_08580	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_08585	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L25_08590	COG0183	Belongs to the thiolase family
I6L25_08600	COG2814	Major facilitator Superfamily
I6L25_08610	COG1024	Enoyl-CoA hydratase
I6L25_08630	COG2814	Major facilitator Superfamily
I6L25_08635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L25_08640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6L25_08655	COG3842	ATPase activity
I6L25_08660	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L25_08670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L25_08675	COG1414	Transcriptional regulator
I6L25_08685	COG0583	DNA-binding transcription factor activity
I6L25_08705	COG3038	cytochrome b561
I6L25_08710	COG0753	catalase activity
I6L25_08715	COG1733	regulation of RNA biosynthetic process
I6L25_08740	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_08745	COG0583	DNA-binding transcription factor activity
I6L25_08750	COG2050	protein possibly involved in aromatic compounds catabolism
I6L25_08760	COG3327	negative regulation of DNA-templated transcription, initiation
I6L25_08765	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6L25_08770	COG0183	Belongs to the thiolase family
I6L25_08775	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L25_08780	COG1024	Enoyl-CoA hydratase
I6L25_08785	COG1024	Enoyl-CoA hydratase
I6L25_08790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L25_08795	COG2151	metal-sulfur cluster biosynthetic enzyme
I6L25_08800	COG3396	Phenylacetate-CoA oxygenase
I6L25_08805	COG3460	Phenylacetate-CoA oxygenase
I6L25_08810	COG3396	Phenylacetate-CoA oxygenase
I6L25_08815	COG1012	belongs to the aldehyde dehydrogenase family
I6L25_08815	COG2030	dehydratase
I6L25_08820	COG1760	l-serine dehydratase
I6L25_08825	COG0531	amino acid
I6L25_08830	COG1012	belongs to the aldehyde dehydrogenase family
I6L25_08855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L25_08875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L25_08885	COG0789	Transcriptional regulator
I6L25_08895	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6L25_08910	COG2807	transmembrane transport
I6L25_08915	COG0590	tRNA wobble adenosine to inosine editing
I6L25_08960	COG2885	chlorophyll binding
I6L25_09020	COG0477	Major facilitator Superfamily
I6L25_09035	COG1116	anion transmembrane transporter activity
I6L25_09040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L25_09050	COG0864	Transcriptional regulator
I6L25_09060	COG1733	regulation of RNA biosynthetic process
I6L25_09065	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L25_09070	COG0439	Biotin carboxylase
I6L25_09085	COG1063	alcohol dehydrogenase
I6L25_09115	COG0038	chloride channel
I6L25_09120	COG4770	biotin carboxylase activity
I6L25_09140	COG1914	H( )-stimulated, divalent metal cation uptake system
I6L25_09145	COG0583	DNA-binding transcription factor activity
I6L25_09155	COG1595	DNA-templated transcription, initiation
I6L25_09165	COG3220	belongs to the UPF0276 family
I6L25_09180	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_09195	COG2076	Multidrug Resistance protein
I6L25_09210	COG3713	MltA-interacting MipA family protein
I6L25_09215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L25_09320	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L25_09335	COG0789	Transcriptional regulator
I6L25_09340	COG1278	Cold shock
I6L25_09350	COG0626	cystathionine gamma-synthase activity
I6L25_09360	COG1522	sequence-specific DNA binding
I6L25_09370	COG4774	siderophore transport
I6L25_09390	COG2814	Major facilitator Superfamily
I6L25_09430	COG1960	acyl-CoA dehydrogenase activity
I6L25_09440	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_09450	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_09470	COG0583	DNA-binding transcription factor activity
I6L25_09475	COG1473	amidohydrolase
I6L25_09480	COG1278	Cold shock
I6L25_09545	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_09560	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6L25_09570	COG4122	O-methyltransferase activity
I6L25_09595	COG2801	Transposase and inactivated derivatives
I6L25_09610	COG1538	Outer membrane efflux protein
I6L25_09615	COG1137	ATPase activity
I6L25_09620	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6L25_09630	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6L25_09635	COG0517	IMP dehydrogenase activity
I6L25_09635	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L25_09710	COG1280	lysine exporter protein (LysE YggA)
I6L25_09740	COG1570	exodeoxyribonuclease VII activity
I6L25_09790	COG0583	DNA-binding transcription factor activity
I6L25_09795	COG4638	Rieske (2fe-2S)
I6L25_09800	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6L25_09805	COG0543	2 iron, 2 sulfur cluster binding
I6L25_09805	COG0633	Ferredoxin
I6L25_09810	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_09815	COG3135	benzoate transporter
I6L25_09820	COG2814	Major facilitator Superfamily
I6L25_09835	COG1643	Atp-dependent helicase
I6L25_09840	COG0450	alkyl hydroperoxide reductase
I6L25_09860	COG3634	alkyl hydroperoxide reductase activity
I6L25_09880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6L25_09890	COG0625	glutathione transferase activity
I6L25_09900	COG2885	chlorophyll binding
I6L25_09935	COG0542	response to heat
I6L25_09950	COG1765	OsmC-like protein
I6L25_09960	COG0667	Aldo Keto reductase
I6L25_09975	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6L25_09995	COG0527	aspartate kinase activity
I6L25_10005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6L25_10015	COG3038	cytochrome b561
I6L25_10020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L25_10025	COG2252	PERMEase
I6L25_10035	COG2072	flavoprotein involved in K transport
I6L25_10050	COG1741	Belongs to the pirin family
I6L25_10055	COG1309	transcriptional regulator
I6L25_10070	COG2072	flavoprotein involved in K transport
I6L25_10075	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6L25_10105	COG1944	ATP diphosphatase activity
I6L25_10125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L25_10140	COG2814	Major facilitator Superfamily
I6L25_10145	COG1024	Enoyl-CoA hydratase
I6L25_10160	COG1960	acyl-CoA dehydrogenase activity
I6L25_10180	COG0697	spore germination
I6L25_10195	COG1113	amino acid transport
I6L25_10215	COG1012	belongs to the aldehyde dehydrogenase family
I6L25_10235	COG0531	amino acid
I6L25_10245	COG1113	amino acid transport
I6L25_10350	COG1902	pentaerythritol trinitrate reductase activity
I6L25_10350	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L25_10365	COG3706	GGDEF domain
I6L25_10365	COG4251	negative regulation of phosphorylation
I6L25_10365	COG2203	Gaf domain
I6L25_10365	COG5001	Diguanylate cyclase
I6L25_10375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L25_10400	COG4172	Belongs to the ABC transporter superfamily
I6L25_10405	COG4239	(ABC) transporter, permease
I6L25_10410	COG4174	ABC transporter (Permease)
I6L25_10420	COG0741	lytic transglycosylase activity
I6L25_10420	COG1388	LysM domain
I6L25_10420	COG0741	lytic transglycosylase activity
I6L25_10420	COG1388	LysM domain
I6L25_10460	COG0583	DNA-binding transcription factor activity
I6L25_10465	COG1279	arginine transmembrane transporter activity
I6L25_10485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L25_10490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L25_10495	COG0006	proline dipeptidase activity
I6L25_10530	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L25_10575	COG3384	dioxygenase
I6L25_10585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L25_10590	COG2878	Part of a membrane complex involved in electron transport
I6L25_10595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L25_10620	COG0768	penicillin binding
I6L25_10625	COG0742	ribosomal rna small subunit methyltransferase
I6L25_10645	COG0830	nickel cation binding
I6L25_10655	COG0804	urea catabolic process
I6L25_10695	COG1253	flavin adenine dinucleotide binding
I6L25_10700	COG2851	Citrate transporter
I6L25_10750	COG1773	rubredoxin
I6L25_10755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L25_10765	COG0583	DNA-binding transcription factor activity
I6L25_10790	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6L25_10795	COG4181	ATPase activity
I6L25_10840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L25_10860	COG0306	phosphate transporter
I6L25_10895	COG2223	nitrite transmembrane transporter activity
I6L25_10900	COG2207	Transcriptional regulator
I6L25_10900	COG0662	Cupin 2, conserved barrel domain protein
I6L25_10905	COG2066	Belongs to the glutaminase family
I6L25_10910	COG0242	peptide deformylase activity
I6L25_10915	COG0477	Major facilitator Superfamily
I6L25_10925	COG0028	Belongs to the TPP enzyme family
I6L25_10940	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_10945	COG2267	carboxylic ester hydrolase activity
I6L25_10955	COG2271	Major facilitator Superfamily
I6L25_10960	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L25_10970	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_10990	COG1414	Transcriptional regulator
I6L25_11015	COG1024	Enoyl-CoA hydratase
I6L25_11025	COG1215	transferase activity, transferring glycosyl groups
I6L25_11030	COG1649	PFAM Uncharacterised BCR, COG1649
I6L25_11030	COG0726	polysaccharide deacetylase
I6L25_11040	COG4681	YaeQ
I6L25_11050	COG0523	cobalamin synthesis protein
I6L25_11060	COG1607	acyl-coa hydrolase
I6L25_11070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L25_11075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L25_11080	COG1309	transcriptional regulator
I6L25_11105	COG2040	homocysteine
I6L25_11110	COG0531	amino acid
I6L25_11135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L25_11140	COG0477	Major facilitator Superfamily
I6L25_11190	COG0405	Gamma-glutamyltransferase
I6L25_11195	COG2814	Major facilitator Superfamily
I6L25_11205	COG2050	protein possibly involved in aromatic compounds catabolism
I6L25_11220	COG1090	epimerase
I6L25_11240	COG0420	3'-5' exonuclease activity
I6L25_11250	COG1968	undecaprenyl-diphosphatase activity
I6L25_11270	COG0735	belongs to the Fur family
I6L25_11275	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L25_11295	COG0121	glutamine amidotransferase
I6L25_11310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L25_11320	COG0210	DNA helicase
I6L25_11325	COG2885	chlorophyll binding
I6L25_11330	COG0204	Acyl-transferase
I6L25_11345	COG2894	cell division
I6L25_11365	COG1280	lysine exporter protein (LysE YggA)
I6L25_11370	COG1674	ftsk spoiiie
I6L25_11375	COG0492	ferredoxin-NADP+ reductase activity
I6L25_11380	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6L25_11390	COG0456	acetyltransferase
I6L25_11420	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6L25_11435	COG1981	membrane
I6L25_11450	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6L25_11450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L25_11470	COG1012	belongs to the aldehyde dehydrogenase family
I6L25_11475	COG4638	Rieske (2fe-2S)
I6L25_11480	COG0657	acetylesterase activity
I6L25_11490	COG0473	3-isopropylmalate dehydrogenase activity
I6L25_11495	COG0583	DNA-binding transcription factor activity
I6L25_11515	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L25_11550	COG0358	DNA primase activity
I6L25_11565	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6L25_11595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L25_11625	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L25_11635	COG0351	phosphomethylpyrimidine kinase
I6L25_11635	COG0352	thiamine-phosphate diphosphorylase activity
I6L25_11635	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6L25_11640	COG1652	LysM domain
I6L25_11665	COG1399	metal-binding, possibly nucleic acid-binding protein
I6L25_11670	COG3101	peptidyl-lysine hydroxylation
I6L25_11675	COG0009	L-threonylcarbamoyladenylate synthase
I6L25_11680	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6L25_11685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6L25_11700	COG4106	trans-aconitate 2-methyltransferase activity
I6L25_11715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L25_11715	COG0596	Alpha beta hydrolase
I6L25_11715	COG2226	methyltransferase
I6L25_11720	COG1877	trehalose-phosphatase activity
I6L25_11725	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6L25_11730	COG2223	nitrite transmembrane transporter activity
I6L25_11750	COG1196	nuclear chromosome segregation
I6L25_11760	COG0730	response to heat
I6L25_11775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L25_11835	COG0489	protein tyrosine kinase activity
I6L25_11845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L25_11845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L25_11880	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6L25_11885	COG2081	HI0933 family
I6L25_11895	COG0668	transmembrane transport
I6L25_11915	COG0583	DNA-binding transcription factor activity
I6L25_11940	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L25_11945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L25_11975	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6L25_12000	COG3706	GGDEF domain
I6L25_12015	COG0745	RESPONSE REGULATOR receiver
I6L25_12035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L25_12045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L25_12165	COG1309	transcriptional regulator
I6L25_12170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L25_12185	COG0583	DNA-binding transcription factor activity
I6L25_12195	COG0583	DNA-binding transcription factor activity
I6L25_12210	COG0583	DNA-binding transcription factor activity
I6L25_12215	COG1053	succinate dehydrogenase
I6L25_12225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6L25_12230	COG2814	Major facilitator Superfamily
I6L25_12235	COG1960	acyl-CoA dehydrogenase activity
I6L25_12240	COG0583	DNA-binding transcription factor activity
I6L25_12245	COG1063	alcohol dehydrogenase
I6L25_12275	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6L25_12280	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6L25_12305	COG2132	Multicopper oxidase
I6L25_12315	COG0561	phosphatase activity
I6L25_12320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L25_12345	COG1214	PFAM Peptidase M22, glycoprotease
I6L25_12395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6L25_12405	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6L25_12410	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6L25_12415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6L25_12475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L25_12485	COG1846	Transcriptional regulator
I6L25_12490	COG1764	response to oxidative stress
I6L25_12530	COG0037	tRNA processing
I6L25_12540	COG0248	Ppx GppA phosphatase
I6L25_12570	COG0072	phenylalanine-tRNA ligase activity
I6L25_12600	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6L25_12610	COG1238	metal cluster binding
I6L25_12615	COG0625	glutathione transferase activity
I6L25_12630	COG0318	PFAM AMP-dependent synthetase and ligase
I6L25_12635	COG3028	Belongs to the UPF0307 family
I6L25_12640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L25_12660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6L25_12665	COG0617	tRNA 3'-terminal CCA addition
I6L25_12670	COG1555	photosystem II stabilization
I6L25_12675	COG3956	TIGRFAM MazG family protein
I6L25_12685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L25_12705	COG0784	Response regulator, receiver
I6L25_12705	COG2205	protein histidine kinase activity
I6L25_12705	COG5002	protein histidine kinase activity
I6L25_12710	COG1024	Enoyl-CoA hydratase
I6L25_12715	COG2084	Dehydrogenase
I6L25_12720	COG3622	Belongs to the hyi family
I6L25_12750	COG0697	spore germination
I6L25_12760	COG2814	Major facilitator Superfamily
I6L25_12820	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6L25_12885	COG1802	Transcriptional regulator
I6L25_12885	COG4626	Terminase
I6L25_12990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L25_13010	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6L25_13020	COG0084	hydrolase, TatD family'
I6L25_13035	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6L25_13065	COG0440	acetolactate synthase activity
I6L25_13070	COG0028	Belongs to the TPP enzyme family
I6L25_13095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L25_13100	COG0577	efflux transmembrane transporter activity
I6L25_13100	COG1136	(ABC) transporter
I6L25_13105	COG1538	Outer membrane efflux protein
I6L25_13120	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6L25_13125	COG1162	GTPase activity
I6L25_13135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L25_13155	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L25_13175	COG1426	Protein conserved in bacteria
I6L25_13210	COG0793	Belongs to the peptidase S41A family
I6L25_13225	COG2267	carboxylic ester hydrolase activity
I6L25_13235	COG1012	belongs to the aldehyde dehydrogenase family
I6L25_13240	COG3265	gluconokinase activity
I6L25_13250	COG0800	Aldolase
I6L25_13260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L25_13265	COG0280	phosphate acetyltransferase
I6L25_13265	COG0857	belongs to the CobB CobQ family
I6L25_13270	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L25_13270	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L25_13290	COG0740	serine-type endopeptidase activity
I6L25_13300	COG4774	siderophore transport
I6L25_13310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L25_13320	COG2813	Specifically methylates the guanine in position
I6L25_13320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L25_13425	COG0788	formyltetrahydrofolate deformylase activity
I6L25_13450	COG4651	solute:proton antiporter activity
I6L25_13450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L25_13470	COG0724	RNA recognition motif
I6L25_13475	COG0210	DNA helicase
I6L25_13500	COG1733	regulation of RNA biosynthetic process
I6L25_13510	COG2900	Belongs to the SlyX family
I6L25_13515	COG0488	(ABC) transporter
I6L25_13525	COG1280	lysine exporter protein (LysE YggA)
I6L25_13530	COG1560	Kdo2-lipid A biosynthetic process
I6L25_13540	COG1301	dicarboxylic acid transport
I6L25_13595	COG0473	3-isopropylmalate dehydrogenase activity
I6L25_13620	COG0583	DNA-binding transcription factor activity
I6L25_13665	COG0583	DNA-binding transcription factor activity
I6L25_13675	COG0625	glutathione transferase activity
I6L25_13680	COG2378	regulation of single-species biofilm formation
I6L25_13695	COG1530	ribonuclease E activity
I6L25_13700	COG0318	PFAM AMP-dependent synthetase and ligase
I6L25_13715	COG0583	DNA-binding transcription factor activity
I6L25_13720	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_13725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L25_13735	COG0534	Mate efflux family protein
I6L25_13750	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L25_13775	COG0493	'glutamate synthase
I6L25_13785	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6L25_13790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L25_13805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6L25_13815	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6L25_13815	COG0644	oxidoreductase
I6L25_13830	COG4535	Mg2 and Co2 transporter CorC
I6L25_13840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L25_13865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L25_13870	COG0475	glutathione-regulated potassium exporter activity
I6L25_13870	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L25_13875	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6L25_13885	COG0484	heat shock protein binding
I6L25_13890	COG0789	Transcriptional regulator
I6L25_13895	COG0598	Magnesium transport protein CorA
I6L25_13900	COG1185	polyribonucleotide nucleotidyltransferase activity
I6L25_13910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L25_13915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L25_13920	COG1074	ATP-dependent DNA helicase activity
I6L25_13925	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6L25_13950	COG2226	methyltransferase
I6L25_13960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L25_13975	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6L25_13990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L25_13990	COG2111	Na H antiporter
I6L25_13995	COG1006	Multisubunit Na H antiporter MnhC subunit
I6L25_14000	COG0651	ATP synthesis coupled electron transport
I6L25_14005	COG1863	multisubunit Na H antiporter MnhE subunit
I6L25_14010	COG2212	antiporter activity
I6L25_14015	COG1320	monovalent cation:proton antiporter activity
I6L25_14020	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6L25_14030	COG0195	Participates in both transcription termination and antitermination
I6L25_14080	COG0237	dephospho-CoA kinase activity
I6L25_14090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L25_14105	COG0497	DNA recombination
I6L25_14115	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6L25_14130	COG1289	transmembrane transporter activity
I6L25_14145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L25_14145	COG2169	Transcriptional regulator
I6L25_14150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L25_14195	COG3545	Serine hydrolase
I6L25_14210	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6L25_14225	COG0326	Molecular chaperone. Has ATPase activity
I6L25_14240	COG2056	Na+-H+ antiporter family
I6L25_14245	COG0596	Alpha beta hydrolase
I6L25_14340	COG0546	phosphoglycolate phosphatase activity
I6L25_14345	COG1716	ATPase activity
I6L25_14390	COG0181	hydroxymethylbilane synthase activity
I6L25_14400	COG3275	phosphorelay sensor kinase activity
I6L25_14420	COG1538	Outer membrane efflux protein
I6L25_14425	COG0697	spore germination
I6L25_14445	COG0494	nUDIX hydrolase
I6L25_14450	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6L25_14455	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L25_14460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L25_14465	COG0772	Belongs to the SEDS family
I6L25_14490	COG4974	Belongs to the 'phage' integrase family
I6L25_14495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L25_14505	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L25_14515	COG2197	response regulator
I6L25_14530	COG0793	Belongs to the peptidase S41A family
I6L25_14535	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6L25_14540	COG0795	lipopolysaccharide-transporting ATPase activity
I6L25_14580	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L25_14580	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L25_14590	COG0004	ammonium transporteR
I6L25_14595	COG0347	Belongs to the P(II) protein family
I6L25_14605	COG0606	chelatase, subunit chli
I6L25_14610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L25_14615	COG0235	Class ii aldolase
I6L25_14620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L25_14635	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L25_14650	COG0318	PFAM AMP-dependent synthetase and ligase
I6L25_14660	COG0477	Major facilitator Superfamily
I6L25_14665	COG2860	membrane
I6L25_14675	COG1253	flavin adenine dinucleotide binding
I6L25_14685	COG2814	Major facilitator Superfamily
I6L25_14695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L25_14730	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6L25_14745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L25_14780	COG1309	transcriptional regulator
I6L25_14815	COG0758	DNA mediated transformation
I6L25_14825	COG0697	spore germination
I6L25_14830	COG1309	transcriptional regulator
I6L25_14845	COG0386	Belongs to the glutathione peroxidase family
I6L25_14855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6L25_14910	COG1121	(ABC) transporter
I6L25_14915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L25_14920	COG1280	lysine exporter protein (LysE YggA)
I6L25_14925	COG2837	iron assimilation
I6L25_14935	COG0281	malic enzyme
I6L25_14970	COG0735	belongs to the Fur family
I6L25_14980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L25_14985	COG0519	Catalyzes the synthesis of GMP from XMP
I6L25_14985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L25_14990	COG4399	Belongs to the UPF0754 family
I6L25_14995	COG2259	Doxx family
I6L25_15000	COG0586	Pfam SNARE associated Golgi protein
I6L25_15015	COG1192	Involved in chromosome partitioning
I6L25_15025	COG0271	Belongs to the BolA IbaG family
I6L25_15070	COG1960	acyl-CoA dehydrogenase activity
I6L25_15075	COG0318	PFAM AMP-dependent synthetase and ligase
I6L25_15080	COG2197	response regulator
I6L25_15090	COG3916	Acyl-homoserine-lactone synthase
I6L25_15095	COG0477	Major facilitator Superfamily
I6L25_15100	COG1024	Enoyl-CoA hydratase
I6L25_15105	COG1024	Enoyl-CoA hydratase
I6L25_15110	COG1960	acyl-CoA dehydrogenase activity
I6L25_15115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L25_15135	COG1113	amino acid transport
I6L25_15140	COG1113	amino acid transport
I6L25_15145	COG0251	oxidation-reduction process
I6L25_15185	COG0564	pseudouridine synthase activity
I6L25_15250	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6L25_15265	COG1802	Transcriptional regulator
I6L25_15275	COG1448	Aminotransferase
I6L25_15280	COG0277	FAD linked oxidase domain protein
I6L25_15290	COG2186	Transcriptional regulator
I6L25_15300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L25_15310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L25_15325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L25_15330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6L25_15340	COG0438	transferase activity, transferring glycosyl groups
I6L25_15345	COG0438	transferase activity, transferring glycosyl groups
I6L25_15350	COG1216	Glycosyl transferase, family 2
I6L25_15350	COG0463	Glycosyl transferase, family 2
I6L25_15370	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6L25_15380	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6L25_15385	COG1596	polysaccharide export
I6L25_15410	COG0728	peptidoglycan biosynthetic process
I6L25_15415	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L25_15470	COG0546	phosphoglycolate phosphatase activity
I6L25_15475	COG1028	Short-chain dehydrogenase reductase Sdr
I6L25_15490	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L25_15490	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6L25_15495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L25_15500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L25_15505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L25_15510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L25_15515	COG1116	anion transmembrane transporter activity
I6L25_15520	COG1309	transcriptional regulator
I6L25_15525	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6L25_15535	COG0196	riboflavin kinase activity
I6L25_15540	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6L25_15550	COG1047	Peptidyl-prolyl cis-trans
I6L25_15590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L25_15595	COG0657	acetylesterase activity
I6L25_15645	COG2951	lytic endotransglycosylase activity
I6L25_15650	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6L25_15665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L25_15675	COG0671	phosphoesterase, PA-phosphatase related
I6L25_15680	COG0861	Integral membrane protein TerC family
I6L25_15690	COG0754	glutathionylspermidine amidase activity
I6L25_15700	COG0402	S-adenosylhomocysteine deaminase activity
I6L25_15715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L25_15720	COG1230	cation diffusion facilitator family transporter
I6L25_15735	COG0706	membrane insertase activity
I6L25_15760	COG0592	DNA-directed DNA polymerase activity
I6L25_15770	COG0187	DNA topoisomerase II activity
I6L25_15780	COG0586	Pfam SNARE associated Golgi protein
I6L25_15785	COG0488	(ABC) transporter
I6L25_15810	COG0596	Alpha beta hydrolase
I6L25_15815	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6L25_15820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L25_15860	COG0733	neurotransmitter:sodium symporter activity
I6L25_15900	COG2233	PERMEase
I6L25_15915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L25_15950	COG2814	Major facilitator Superfamily
I6L25_15955	COG0656	L-ascorbic acid biosynthetic process
I6L25_15960	COG0583	DNA-binding transcription factor activity
I6L25_15970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L25_15975	COG1064	alcohol dehydrogenase
I6L25_15980	COG2818	Glycosylase
I6L25_15995	COG1194	a g-specific adenine glycosylase
I6L25_16010	COG5487	UPF0391 membrane protein
I6L25_16015	COG2983	Belongs to the UPF0260 family
I6L25_16020	COG2133	pyrroloquinoline quinone binding
I6L25_16025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L25_16030	COG2116	formate transmembrane transporter activity
I6L25_16050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L25_16055	COG1335	isochorismatase
I6L25_16060	COG0385	Bile acid
I6L25_16065	COG0534	Mate efflux family protein
I6L25_16070	COG1683	Conserved Protein
I6L25_16090	COG0625	glutathione transferase activity
I6L25_16100	COG1113	amino acid transport
I6L25_16110	COG0523	cobalamin synthesis protein
I6L25_16120	COG2188	Transcriptional regulator
I6L25_16150	COG0010	Belongs to the arginase family
I6L25_16165	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6L25_16170	COG1280	lysine exporter protein (LysE YggA)
I6L25_16200	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6L25_16205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6L25_16215	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6L25_16220	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6L25_16310	COG0534	Mate efflux family protein
I6L25_16315	COG0436	Aminotransferase
I6L25_16320	COG2733	membrane
I6L25_16335	COG2918	glutathione biosynthetic process
I6L25_16350	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6L25_16350	COG3409	Peptidoglycan-binding domain 1 protein
I6L25_16350	COG1388	LysM domain
I6L25_16380	COG3150	esterase
I6L25_16390	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6L25_16400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L25_16410	COG2233	PERMEase
I6L25_16415	COG2351	hydroxyisourate hydrolase activity
I6L25_16450	COG3706	GGDEF domain
I6L25_16465	COG1393	Belongs to the ArsC family
I6L25_16470	COG0708	Exodeoxyribonuclease III
I6L25_16490	COG0189	ligase activity
I6L25_16510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6L25_16520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6L25_16535	COG4942	peptidase
I6L25_16545	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L25_16555	COG2119	membrane
I6L25_16560	COG0426	domain, Protein
I6L25_16560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L25_16585	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6L25_16605	COG1902	pentaerythritol trinitrate reductase activity
I6L25_16610	COG1519	Transferase
I6L25_16615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L25_16620	COG0668	transmembrane transport
I6L25_16630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L25_16635	COG1335	isochorismatase
I6L25_16640	COG1522	sequence-specific DNA binding
I6L25_16665	COG2205	protein histidine kinase activity
I6L25_16665	COG2198	Histidine kinase
I6L25_16665	COG0784	Response regulator, receiver
I6L25_16670	COG3162	membrane
I6L25_16675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L25_16685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L25_16705	COG1309	transcriptional regulator
I6L25_16725	COG0352	thiamine-phosphate diphosphorylase activity
I6L25_16725	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6L25_16725	COG0351	phosphomethylpyrimidine kinase
I6L25_16735	COG2814	Major facilitator Superfamily
I6L25_16750	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6L25_16760	COG1113	amino acid transport
I6L25_16770	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L25_16775	COG1012	belongs to the aldehyde dehydrogenase family
I6L25_16785	COG1335	isochorismatase
I6L25_16820	COG2814	Major facilitator Superfamily
I6L25_16825	COG0583	DNA-binding transcription factor activity
I6L25_16845	COG0667	Aldo Keto reductase
I6L25_16870	COG1733	regulation of RNA biosynthetic process
I6L25_16880	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L25_16945	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L25_16985	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L25_17015	COG0427	acetyl-CoA hydrolase
I6L25_17035	COG0659	secondary active sulfate transmembrane transporter activity
I6L25_17040	COG4221	oxidoreductase activity
I6L25_17050	COG0028	Belongs to the TPP enzyme family
I6L25_17055	COG0488	(ABC) transporter
I6L25_17120	COG0833	amino acid
I6L25_17165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L25_17170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L25_17185	COG2226	methyltransferase
I6L25_17235	COG0070	glutamate synthase
I6L25_17235	COG0069	glutamate synthase activity
I6L25_17235	COG0067	glutamate synthase
I6L25_17240	COG0493	'glutamate synthase
I6L25_17250	COG1704	LemA family
I6L25_17255	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L25_17275	COG3307	-O-antigen
I6L25_17295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L25_17310	COG0194	GDP metabolic process
I6L25_17360	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6L25_17380	COG5380	lipid catabolic process
I6L25_17385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6L25_17400	COG5006	permease, DMT superfamily
I6L25_17405	COG5006	permease, DMT superfamily
I6L25_17410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L25_17415	COG0277	FAD linked oxidase domain protein
I6L25_17430	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6L25_17435	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L25_17450	COG1289	transmembrane transporter activity
I6L25_17455	COG2032	superoxide dismutase activity
I6L25_17460	COG0628	permease
I6L25_17465	COG1192	Involved in chromosome partitioning
I6L25_17495	COG0833	amino acid
I6L25_17500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L25_17505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L25_17515	COG1012	belongs to the aldehyde dehydrogenase family
I6L25_17555	COG0583	DNA-binding transcription factor activity
I6L25_17600	COG0517	IMP dehydrogenase activity
I6L25_17605	COG1983	PspC domain protein
I6L25_17615	COG1960	acyl-CoA dehydrogenase activity
I6L25_17630	COG0408	coproporphyrinogen oxidase activity
I6L25_17660	COG1127	ABC transporter
I6L25_17665	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6L25_17675	COG2854	intermembrane phospholipid transfer
I6L25_17685	COG0598	Magnesium transport protein CorA
I6L25_17695	COG0494	nUDIX hydrolase
I6L25_17700	COG1040	competence protein
I6L25_17705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L25_17725	COG1946	Acyl-CoA thioesterase
I6L25_17730	COG1301	dicarboxylic acid transport
I6L25_17745	COG1959	2 iron, 2 sulfur cluster binding
I6L25_17750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L25_17750	COG1017	nitric oxide dioxygenase activity
I6L25_17755	COG0433	COG0433 Predicted ATPase
I6L25_17760	COG0626	cystathionine gamma-synthase activity
I6L25_17775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6L25_17780	COG0088	Forms part of the polypeptide exit tunnel
I6L25_17915	COG1960	acyl-CoA dehydrogenase activity
I6L25_17920	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6L25_17950	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6L25_17955	COG0339	signal peptide processing
I6L25_17960	COG0557	exoribonuclease II activity
I6L25_18005	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6L25_18010	COG2207	Transcriptional regulator
I6L25_18020	COG1295	ribonuclease BN
I6L25_18055	COG1702	phosphate starvation-inducible protein PhoH
I6L25_18065	COG1196	nuclear chromosome segregation
I6L25_18065	COG0741	lytic transglycosylase activity
I6L25_18065	COG0739	heme binding
I6L25_18095	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6L25_18100	COG1183	phosphatidylcholine synthase activity
I6L25_18150	COG1960	acyl-CoA dehydrogenase activity
I6L25_18155	COG1309	transcriptional regulator
I6L25_18170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L25_18175	COG1960	acyl-CoA dehydrogenase activity
I6L25_18215	COG2969	positive regulation of protein catabolic process
I6L25_18225	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6L25_18230	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6L25_18235	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6L25_18240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6L25_18245	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L25_18265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L25_18275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L25_18280	COG1408	metallophosphoesterase
I6L25_18290	COG2199	diguanylate cyclase activity
I6L25_18350	COG1607	acyl-coa hydrolase