locus-tag	class	description
FRD49_00010	COG0592	DNA-directed DNA polymerase activity
FRD49_00020	COG0187	DNA topoisomerase II activity
FRD49_00030	COG0586	Pfam SNARE associated Golgi protein
FRD49_00035	COG0488	(ABC) transporter
FRD49_00060	COG0596	Alpha beta hydrolase
FRD49_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FRD49_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FRD49_00115	COG0733	neurotransmitter:sodium symporter activity
FRD49_00155	COG2233	PERMEase
FRD49_00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRD49_00205	COG2814	Major facilitator Superfamily
FRD49_00210	COG0656	L-ascorbic acid biosynthetic process
FRD49_00215	COG0583	DNA-binding transcription factor activity
FRD49_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRD49_00230	COG1064	alcohol dehydrogenase
FRD49_00235	COG2818	Glycosylase
FRD49_00250	COG1194	a g-specific adenine glycosylase
FRD49_00265	COG5487	UPF0391 membrane protein
FRD49_00270	COG2983	Belongs to the UPF0260 family
FRD49_00275	COG2133	pyrroloquinoline quinone binding
FRD49_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FRD49_00285	COG2116	formate transmembrane transporter activity
FRD49_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRD49_00310	COG1335	isochorismatase
FRD49_00315	COG0385	Bile acid
FRD49_00320	COG0534	Mate efflux family protein
FRD49_00325	COG1683	Conserved Protein
FRD49_00345	COG0625	glutathione transferase activity
FRD49_00355	COG1113	amino acid transport
FRD49_00365	COG0523	cobalamin synthesis protein
FRD49_00375	COG2188	Transcriptional regulator
FRD49_00405	COG0010	Belongs to the arginase family
FRD49_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FRD49_00435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FRD49_00445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FRD49_00450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FRD49_00545	COG0534	Mate efflux family protein
FRD49_00550	COG0436	Aminotransferase
FRD49_00555	COG2733	membrane
FRD49_00570	COG2918	glutathione biosynthetic process
FRD49_00580	COG3501	Rhs element vgr protein
FRD49_00645	COG3150	esterase
FRD49_00655	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FRD49_00665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRD49_00675	COG2233	PERMEase
FRD49_00680	COG2351	hydroxyisourate hydrolase activity
FRD49_00715	COG3706	GGDEF domain
FRD49_00730	COG1393	Belongs to the ArsC family
FRD49_00735	COG0708	Exodeoxyribonuclease III
FRD49_00755	COG0189	ligase activity
FRD49_00780	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FRD49_00790	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FRD49_00805	COG4942	peptidase
FRD49_00815	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRD49_00825	COG2119	membrane
FRD49_00830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRD49_00830	COG0426	domain, Protein
FRD49_00855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FRD49_00875	COG1902	pentaerythritol trinitrate reductase activity
FRD49_00880	COG1519	Transferase
FRD49_00885	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FRD49_00890	COG0668	transmembrane transport
FRD49_00900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRD49_00905	COG1335	isochorismatase
FRD49_00910	COG1522	sequence-specific DNA binding
FRD49_00935	COG2205	protein histidine kinase activity
FRD49_00935	COG2198	Histidine kinase
FRD49_00935	COG0784	Response regulator, receiver
FRD49_00940	COG3162	membrane
FRD49_00945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FRD49_00955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FRD49_00965	COG3706	GGDEF domain
FRD49_00975	COG1309	transcriptional regulator
FRD49_00995	COG0300	oxidoreductase activity
FRD49_01005	COG0351	phosphomethylpyrimidine kinase
FRD49_01005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FRD49_01005	COG0352	thiamine-phosphate diphosphorylase activity
FRD49_01015	COG2814	Major facilitator Superfamily
FRD49_01055	COG1196	nuclear chromosome segregation
FRD49_01070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FRD49_01110	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FRD49_01140	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FRD49_01150	COG1113	amino acid transport
FRD49_01160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FRD49_01165	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_01175	COG1335	isochorismatase
FRD49_01210	COG2814	Major facilitator Superfamily
FRD49_01215	COG0583	DNA-binding transcription factor activity
FRD49_01235	COG0667	Aldo Keto reductase
FRD49_01280	COG1733	regulation of RNA biosynthetic process
FRD49_01290	COG2249	NAD(P)H dehydrogenase (quinone) activity
FRD49_01315	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FRD49_01320	COG2207	Transcriptional regulator
FRD49_01375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FRD49_01440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FRD49_01470	COG0427	acetyl-CoA hydrolase
FRD49_01480	COG2205	protein histidine kinase activity
FRD49_01485	COG0745	RESPONSE REGULATOR receiver
FRD49_01495	COG0659	secondary active sulfate transmembrane transporter activity
FRD49_01500	COG4221	oxidoreductase activity
FRD49_01510	COG0028	Belongs to the TPP enzyme family
FRD49_01515	COG0488	(ABC) transporter
FRD49_01580	COG0833	amino acid
FRD49_01625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FRD49_01630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FRD49_01645	COG2226	methyltransferase
FRD49_01695	COG0067	glutamate synthase
FRD49_01695	COG0069	glutamate synthase activity
FRD49_01695	COG0070	glutamate synthase
FRD49_01700	COG0493	'glutamate synthase
FRD49_01710	COG1704	LemA family
FRD49_01715	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FRD49_01735	COG3307	-O-antigen
FRD49_01755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FRD49_01770	COG0194	GDP metabolic process
FRD49_01805	COG4969	Belongs to the N-Me-Phe pilin family
FRD49_01820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FRD49_01840	COG5380	lipid catabolic process
FRD49_01845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FRD49_01860	COG5006	permease, DMT superfamily
FRD49_01865	COG5006	permease, DMT superfamily
FRD49_01870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FRD49_01875	COG0277	FAD linked oxidase domain protein
FRD49_01890	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FRD49_01895	COG2249	NAD(P)H dehydrogenase (quinone) activity
FRD49_01910	COG1289	transmembrane transporter activity
FRD49_01915	COG2032	superoxide dismutase activity
FRD49_01920	COG0628	permease
FRD49_01925	COG1192	Involved in chromosome partitioning
FRD49_01955	COG0833	amino acid
FRD49_01960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FRD49_01965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRD49_01975	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_02015	COG0583	DNA-binding transcription factor activity
FRD49_02065	COG0517	IMP dehydrogenase activity
FRD49_02070	COG1983	PspC domain protein
FRD49_02080	COG1960	acyl-CoA dehydrogenase activity
FRD49_02095	COG0408	coproporphyrinogen oxidase activity
FRD49_02120	COG1127	ABC transporter
FRD49_02125	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FRD49_02135	COG2854	intermembrane phospholipid transfer
FRD49_02145	COG0598	Magnesium transport protein CorA
FRD49_02155	COG0494	nUDIX hydrolase
FRD49_02160	COG1040	competence protein
FRD49_02165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FRD49_02185	COG1946	Acyl-CoA thioesterase
FRD49_02190	COG1301	dicarboxylic acid transport
FRD49_02205	COG1959	2 iron, 2 sulfur cluster binding
FRD49_02210	COG1017	nitric oxide dioxygenase activity
FRD49_02210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRD49_02215	COG0433	COG0433 Predicted ATPase
FRD49_02220	COG0626	cystathionine gamma-synthase activity
FRD49_02235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FRD49_02240	COG0088	Forms part of the polypeptide exit tunnel
FRD49_02340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FRD49_02350	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FRD49_02375	COG1960	acyl-CoA dehydrogenase activity
FRD49_02380	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FRD49_02410	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
FRD49_02415	COG0339	signal peptide processing
FRD49_02420	COG0557	exoribonuclease II activity
FRD49_02465	COG0179	Fumarylacetoacetate (FAA) hydrolase
FRD49_02470	COG2207	Transcriptional regulator
FRD49_02480	COG1295	ribonuclease BN
FRD49_02515	COG1702	phosphate starvation-inducible protein PhoH
FRD49_02525	COG0739	heme binding
FRD49_02525	COG0741	lytic transglycosylase activity
FRD49_02525	COG1196	nuclear chromosome segregation
FRD49_02555	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FRD49_02560	COG1183	phosphatidylcholine synthase activity
FRD49_02610	COG1960	acyl-CoA dehydrogenase activity
FRD49_02615	COG1309	transcriptional regulator
FRD49_02630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FRD49_02635	COG1960	acyl-CoA dehydrogenase activity
FRD49_02675	COG2969	positive regulation of protein catabolic process
FRD49_02685	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FRD49_02690	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FRD49_02695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FRD49_02700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FRD49_02705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FRD49_02725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FRD49_02735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRD49_02740	COG1408	metallophosphoesterase
FRD49_02750	COG2199	diguanylate cyclase activity
FRD49_02795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRD49_02795	COG3453	Protein conserved in bacteria
FRD49_02810	COG1607	acyl-coa hydrolase
FRD49_02845	COG2350	Protein conserved in bacteria
FRD49_02855	COG0613	PHP domain protein
FRD49_02860	COG3781	membrane
FRD49_02870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FRD49_02875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRD49_02885	COG1862	Preprotein translocase
FRD49_02995	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FRD49_03005	COG0732	type I restriction modification DNA specificity domain
FRD49_03020	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FRD49_03030	COG2198	Histidine kinase
FRD49_03030	COG0784	Response regulator, receiver
FRD49_03030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRD49_03030	COG2205	protein histidine kinase activity
FRD49_03035	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FRD49_03050	COG2194	sulfuric ester hydrolase activity
FRD49_03060	COG0726	polysaccharide deacetylase
FRD49_03065	COG0463	Glycosyl transferase, family 2
FRD49_03070	COG0438	transferase activity, transferring glycosyl groups
FRD49_03140	COG1960	acyl-CoA dehydrogenase activity
FRD49_03145	COG1960	acyl-CoA dehydrogenase activity
FRD49_03155	COG2205	protein histidine kinase activity
FRD49_03160	COG0745	RESPONSE REGULATOR receiver
FRD49_03165	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FRD49_03185	COG2096	Adenosyltransferase
FRD49_03200	COG0133	tryptophan synthase activity
FRD49_03240	COG0285	dihydrofolate synthase activity
FRD49_03260	COG0450	alkyl hydroperoxide reductase
FRD49_03275	COG0477	Major facilitator Superfamily
FRD49_03280	COG1272	protein, Hemolysin III
FRD49_03290	COG2153	protein acetylation
FRD49_03310	COG0183	Belongs to the thiolase family
FRD49_03315	COG2207	Transcriptional regulator
FRD49_03335	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRD49_03355	COG0183	Belongs to the thiolase family
FRD49_03365	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FRD49_03365	COG2885	chlorophyll binding
FRD49_03370	COG1690	Belongs to the RtcB family
FRD49_03375	COG0833	amino acid
FRD49_03385	COG2233	PERMEase
FRD49_03415	COG2094	Belongs to the DNA glycosylase MPG family
FRD49_03420	COG4772	TonB-dependent receptor
FRD49_03425	COG1902	pentaerythritol trinitrate reductase activity
FRD49_03440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FRD49_03445	COG0354	folic acid binding
FRD49_03455	COG3189	MarR family transcriptional regulator
FRD49_03460	COG2824	Alkylphosphonate utilization operon protein PhnA
FRD49_03465	COG3422	double-strand break repair
FRD49_03505	COG0840	transmembrane signaling receptor activity
FRD49_03535	COG2832	Protein of unknown function (DUF454)
FRD49_03540	COG1376	ErfK ybiS ycfS ynhG family protein
FRD49_03580	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FRD49_03590	COG1289	transmembrane transporter activity
FRD49_03595	COG2814	Major facilitator Superfamily
FRD49_03620	COG1115	amino acid carrier protein
FRD49_03625	COG1752	Esterase of the alpha-beta hydrolase superfamily
FRD49_03630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FRD49_03635	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FRD49_03665	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRD49_03675	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRD49_03680	COG1077	Cell shape determining protein MreB Mrl
FRD49_03685	COG1792	Involved in formation and maintenance of cell shape
FRD49_03690	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FRD49_03695	COG0424	maF-like protein
FRD49_03700	COG1530	ribonuclease E activity
FRD49_03710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRD49_03730	COG3293	Transposase
FRD49_03735	COG2249	NAD(P)H dehydrogenase (quinone) activity
FRD49_03760	COG2207	Transcriptional regulator
FRD49_03790	COG3046	protein related to deoxyribodipyrimidine photolyase
FRD49_03795	COG2816	NAD+ diphosphatase activity
FRD49_03800	COG1113	amino acid transport
FRD49_03805	COG2828	Protein conserved in bacteria
FRD49_03810	COG0142	geranyltranstransferase activity
FRD49_03815	COG2315	Protein conserved in bacteria
FRD49_03830	COG1752	Esterase of the alpha-beta hydrolase superfamily
FRD49_03850	COG2194	sulfuric ester hydrolase activity
FRD49_03855	COG0745	RESPONSE REGULATOR receiver
FRD49_03860	COG0642	Histidine kinase
FRD49_03870	COG0004	ammonium transporteR
FRD49_03880	COG0583	DNA-binding transcription factor activity
FRD49_03900	COG0525	valine-tRNA ligase activity
FRD49_03910	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_03920	COG0393	Putative heavy-metal-binding
FRD49_03925	COG0393	Putative heavy-metal-binding
FRD49_03930	COG1538	Outer membrane efflux protein
FRD49_03940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRD49_03945	COG0671	phosphoesterase, PA-phosphatase related
FRD49_03975	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FRD49_03990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FRD49_03990	COG1648	precorrin-2 dehydrogenase activity
FRD49_03995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FRD49_04000	COG1733	regulation of RNA biosynthetic process
FRD49_04010	COG0531	amino acid
FRD49_04025	COG0321	lipoyl(octanoyl) transferase activity
FRD49_04030	COG2921	Belongs to the UPF0250 family
FRD49_04065	COG2009	succinate dehydrogenase
FRD49_04070	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FRD49_04075	COG1053	succinate dehydrogenase
FRD49_04080	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FRD49_04105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRD49_04125	COG2354	Protein conserved in bacteria
FRD49_04130	COG2321	neutral zinc metallopeptidase
FRD49_04150	COG2843	Capsule synthesis protein
FRD49_04170	COG0589	response to stress
FRD49_04180	COG0251	oxidation-reduction process
FRD49_04185	COG1309	transcriptional regulator
FRD49_04200	COG0505	Belongs to the CarA family
FRD49_04230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRD49_04235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FRD49_04285	COG0477	Major facilitator Superfamily
FRD49_04290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FRD49_04310	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FRD49_04330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRD49_04335	COG0584	glycerophosphoryl diester phosphodiesterase
FRD49_04355	COG0741	lytic transglycosylase activity
FRD49_04380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FRD49_04395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRD49_04405	COG3811	Belongs to the UPF0386 family
FRD49_04445	COG1309	transcriptional regulator
FRD49_04450	COG1902	pentaerythritol trinitrate reductase activity
FRD49_04455	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRD49_04455	COG0596	Alpha beta hydrolase
FRD49_04465	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_04475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRD49_04480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRD49_04485	COG0778	Nitroreductase
FRD49_04490	COG0300	oxidoreductase activity
FRD49_04500	COG1929	Belongs to the glycerate kinase type-1 family
FRD49_04505	COG0243	molybdopterin cofactor binding
FRD49_04515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FRD49_04520	COG3339	Conserved Protein
FRD49_04530	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FRD49_04545	COG1113	amino acid transport
FRD49_04550	COG1113	amino acid transport
FRD49_04560	COG0019	diaminopimelate decarboxylase activity
FRD49_04570	COG1280	lysine exporter protein (LysE YggA)
FRD49_04575	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FRD49_04595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRD49_04605	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FRD49_04615	COG0463	Glycosyl transferase, family 2
FRD49_04635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRD49_04665	COG4591	ABC-type transport system involved in lipoprotein release permease component
FRD49_04670	COG1136	(ABC) transporter
FRD49_04685	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FRD49_04685	COG0616	signal peptide processing
FRD49_04690	COG0596	Alpha beta hydrolase
FRD49_04695	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FRD49_04705	COG0628	permease
FRD49_04740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRD49_04760	COG0823	Involved in the tonB-independent uptake of proteins
FRD49_04780	COG0824	Thioesterase
FRD49_04785	COG1473	amidohydrolase
FRD49_04805	COG0047	phosphoribosylformylglycinamidine synthase activity
FRD49_04805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FRD49_04810	COG2814	Major facilitator Superfamily
FRD49_04825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FRD49_04830	COG1024	Enoyl-CoA hydratase
FRD49_04835	COG1051	belongs to the nudix hydrolase family
FRD49_04835	COG1056	cytidyltransferase-related domain
FRD49_04850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FRD49_04865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FRD49_04870	COG0602	queuosine metabolic process
FRD49_04880	COG4625	pathogenesis
FRD49_04885	COG0583	DNA-binding transcription factor activity
FRD49_04890	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FRD49_04895	COG4208	sulfate ABC transporter
FRD49_04900	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FRD49_04910	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FRD49_04915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FRD49_04920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FRD49_04940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRD49_04955	COG0481	GTPase activity
FRD49_04960	COG0681	Belongs to the peptidase S26 family
FRD49_04975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FRD49_04985	COG1381	Involved in DNA repair and RecF pathway recombination
FRD49_04990	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FRD49_05000	COG4221	oxidoreductase activity
FRD49_05050	COG0556	nucleotide-excision repair
FRD49_05105	COG2070	2-Nitropropane dioxygenase
FRD49_05145	COG1215	transferase activity, transferring glycosyl groups
FRD49_05160	COG0415	Belongs to the DNA photolyase family
FRD49_05170	COG1252	NADH dehydrogenase
FRD49_05175	COG1686	Belongs to the peptidase S11 family
FRD49_05190	COG1187	pseudouridine synthase activity
FRD49_05215	COG0477	Major facilitator Superfamily
FRD49_05220	COG0583	DNA-binding transcription factor activity
FRD49_05235	COG0612	Peptidase, M16
FRD49_05260	COG0352	thiamine-phosphate diphosphorylase activity
FRD49_05295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRD49_05320	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FRD49_05325	COG0076	glutamate decarboxylase activity
FRD49_05335	COG1522	sequence-specific DNA binding
FRD49_05340	COG3961	Belongs to the TPP enzyme family
FRD49_05345	COG1113	amino acid transport
FRD49_05350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FRD49_05355	COG0573	inorganic phosphate transmembrane transporter activity
FRD49_05365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FRD49_05370	COG0616	signal peptide processing
FRD49_05385	COG3647	Membrane
FRD49_05410	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FRD49_05415	COG1686	Belongs to the peptidase S11 family
FRD49_05440	COG0583	DNA-binding transcription factor activity
FRD49_05445	COG1067	ATP-dependent peptidase activity
FRD49_05470	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FRD49_05485	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FRD49_05490	COG1966	Carbon starvation protein
FRD49_05495	COG2879	small protein
FRD49_05535	COG0653	protein targeting
FRD49_05560	COG2964	Protein conserved in bacteria
FRD49_05565	COG1741	Belongs to the pirin family
FRD49_05585	COG3739	integral membrane protein
FRD49_05625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FRD49_05635	COG2840	Smr protein MutS2
FRD49_05655	COG2801	Transposase and inactivated derivatives
FRD49_05670	COG0308	aminopeptidase N
FRD49_05675	COG0512	Glutamine amidotransferase of anthranilate synthase
FRD49_05710	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FRD49_05745	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FRD49_05750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FRD49_05755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRD49_05775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FRD49_05780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FRD49_05785	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FRD49_05800	COG1960	acyl-CoA dehydrogenase activity
FRD49_05805	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRD49_05810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRD49_05820	COG2223	nitrite transmembrane transporter activity
FRD49_05830	COG0024	Methionine aminopeptidase
FRD49_05835	COG0052	Belongs to the universal ribosomal protein uS2 family
FRD49_05850	COG2207	Transcriptional regulator
FRD49_05875	COG2951	lytic endotransglycosylase activity
FRD49_05880	COG0772	Belongs to the SEDS family
FRD49_05895	COG0842	Transport permease protein
FRD49_05900	COG1131	(ABC) transporter
FRD49_05930	COG1538	Outer membrane efflux protein
FRD49_05940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRD49_05955	COG4215	(ABC) transporter
FRD49_05960	COG4160	amino acid transport
FRD49_05965	COG4598	ABC transporter
FRD49_05975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FRD49_05985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRD49_05990	COG0384	phenazine biosynthesis protein PhzF
FRD49_06000	COG1720	tRNA m6t6A37 methyltransferase activity
FRD49_06010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FRD49_06015	COG3111	PFAM Bacterial OB fold (BOF) protein
FRD49_06020	COG0745	RESPONSE REGULATOR receiver
FRD49_06025	COG0642	Histidine kinase
FRD49_06035	COG0494	nUDIX hydrolase
FRD49_06045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FRD49_06050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FRD49_06055	COG3139	Protein of unknown function (DUF1315)
FRD49_06060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FRD49_06070	COG1301	dicarboxylic acid transport
FRD49_06075	COG1960	acyl-CoA dehydrogenase activity
FRD49_06085	COG2819	hydrolase of the alpha beta superfamily
FRD49_06095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FRD49_06105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FRD49_06110	COG2195	Cleaves the N-terminal amino acid of tripeptides
FRD49_06115	COG1234	tRNA 3'-trailer cleavage
FRD49_06140	COG2363	Small membrane protein
FRD49_06160	COG0513	Belongs to the DEAD box helicase family
FRD49_06170	COG0778	Nitroreductase
FRD49_06200	COG1286	toxin biosynthetic process
FRD49_06225	COG4783	chaperone-mediated protein folding
FRD49_06230	COG1610	YqeY-like protein
FRD49_06235	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FRD49_06260	COG2815	serine threonine protein kinase
FRD49_06260	COG0515	serine threonine protein kinase
FRD49_06285	COG2831	hemolysin activation secretion protein
FRD49_06410	COG2226	methyltransferase
FRD49_06420	COG3111	PFAM Bacterial OB fold (BOF) protein
FRD49_06435	COG3243	poly(R)-hydroxyalkanoic acid synthase
FRD49_06440	COG0786	glutamate:sodium symporter activity
FRD49_06445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FRD49_06445	COG0475	glutathione-regulated potassium exporter activity
FRD49_06450	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_06520	COG1073	alpha beta
FRD49_06530	COG0583	DNA-binding transcription factor activity
FRD49_06565	COG1051	belongs to the nudix hydrolase family
FRD49_06590	COG3293	Transposase
FRD49_06605	COG2995	paraquat-inducible protein a
FRD49_06610	COG3008	intermembrane lipid transfer
FRD49_06610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FRD49_06620	COG2351	hydroxyisourate hydrolase activity
FRD49_06635	COG5002	protein histidine kinase activity
FRD49_06660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FRD49_06670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FRD49_06675	COG0642	Histidine kinase
FRD49_06680	COG0745	RESPONSE REGULATOR receiver
FRD49_06720	COG1301	dicarboxylic acid transport
FRD49_06735	COG2011	ABC-type metal ion transport system permease component
FRD49_06740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FRD49_06745	COG1464	Belongs to the NlpA lipoprotein family
FRD49_06750	COG0151	Belongs to the GarS family
FRD49_06755	COG0138	bifunctional purine biosynthesis protein purh
FRD49_06760	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FRD49_06790	COG2308	Evidence 4 Homologs of previously reported genes of
FRD49_06800	COG1305	Transglutaminase-like
FRD49_06810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FRD49_06815	COG0305	Participates in initiation and elongation during chromosome replication
FRD49_06840	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FRD49_06850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRD49_06885	COG1215	transferase activity, transferring glycosyl groups
FRD49_06890	COG3658	cytochrome
FRD49_06900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRD49_06925	COG0583	DNA-binding transcription factor activity
FRD49_06945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRD49_06950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRD49_06965	COG1960	acyl-CoA dehydrogenase activity
FRD49_06970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRD49_06975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRD49_07000	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FRD49_07005	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FRD49_07010	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FRD49_07015	COG2205	protein histidine kinase activity
FRD49_07020	COG0745	RESPONSE REGULATOR receiver
FRD49_07025	COG0174	glutamine synthetase
FRD49_07040	COG0477	Major facilitator Superfamily
FRD49_07045	COG0729	surface antigen
FRD49_07075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRD49_07080	COG2814	Major facilitator Superfamily
FRD49_07090	COG0583	DNA-binding transcription factor activity
FRD49_07105	COG1187	pseudouridine synthase activity
FRD49_07125	COG0802	atpase or kinase
FRD49_07130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FRD49_07140	COG1923	regulation of RNA biosynthetic process
FRD49_07145	COG0697	spore germination
FRD49_07175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FRD49_07175	COG0519	Catalyzes the synthesis of GMP from XMP
FRD49_07180	COG4302	ethanolamine ammonia-lyase activity
FRD49_07185	COG4303	Ethanolamine ammonia lyase large subunit
FRD49_07190	COG0531	amino acid
FRD49_07210	COG1454	alcohol dehydrogenase
FRD49_07215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FRD49_07225	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FRD49_07245	COG0308	aminopeptidase N
FRD49_07285	COG0625	glutathione transferase activity
FRD49_07310	COG1605	Chorismate mutase
FRD49_07350	COG4264	IucA IucC family
FRD49_07360	COG4264	IucA IucC family
FRD49_07365	COG2423	ornithine cyclodeaminase activity
FRD49_07370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FRD49_07375	COG0668	transmembrane transport
FRD49_07445	COG0488	(ABC) transporter
FRD49_07450	COG0589	response to stress
FRD49_07465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FRD49_07475	COG3135	benzoate transporter
FRD49_07480	COG1522	sequence-specific DNA binding
FRD49_07490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FRD49_07495	COG0583	DNA-binding transcription factor activity
FRD49_07505	COG0183	Belongs to the thiolase family
FRD49_07545	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FRD49_07555	COG0824	Thioesterase
FRD49_07560	COG1454	alcohol dehydrogenase
FRD49_07570	COG1335	isochorismatase
FRD49_07590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FRD49_07615	COG3293	Transposase
FRD49_07625	COG0069	glutamate synthase activity
FRD49_07665	COG2814	Major facilitator Superfamily
FRD49_07675	COG0439	Biotin carboxylase
FRD49_07680	COG0511	ligase activity, forming carbon-carbon bonds
FRD49_07695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRD49_07695	COG1116	anion transmembrane transporter activity
FRD49_07700	COG0745	RESPONSE REGULATOR receiver
FRD49_07710	COG2146	nitrite reductase [NAD(P)H] activity
FRD49_07710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRD49_07715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRD49_07720	COG0243	molybdopterin cofactor binding
FRD49_07730	COG0243	molybdopterin cofactor binding
FRD49_07735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FRD49_07750	COG0521	Mo-molybdopterin cofactor biosynthetic process
FRD49_07750	COG0315	cyclic pyranopterin monophosphate synthase activity
FRD49_07755	COG0303	'Molybdopterin
FRD49_07765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRD49_07770	COG0697	spore germination
FRD49_07790	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FRD49_07795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FRD49_07855	COG2204	response regulator
FRD49_07860	COG3852	Histidine kinase
FRD49_07885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FRD49_07890	COG0575	Belongs to the CDS family
FRD49_07925	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRD49_07940	COG2137	regulation of response to DNA damage stimulus
FRD49_07950	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FRD49_07955	COG1011	Hydrolase
FRD49_07975	COG1522	sequence-specific DNA binding
FRD49_07985	COG1113	amino acid transport
FRD49_08010	COG0659	secondary active sulfate transmembrane transporter activity
FRD49_08015	COG2135	peptidase activity
FRD49_08030	COG3300	MHYT domain
FRD49_08030	COG5001	Diguanylate cyclase
FRD49_08045	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FRD49_08045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FRD49_08045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FRD49_08050	COG1105	Belongs to the carbohydrate kinase PfkB family
FRD49_08055	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FRD49_08055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FRD49_08085	COG0024	Methionine aminopeptidase
FRD49_08090	COG0583	DNA-binding transcription factor activity
FRD49_08100	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FRD49_08105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRD49_08110	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FRD49_08110	COG0517	IMP dehydrogenase activity
FRD49_08140	COG0552	protein localization to endoplasmic reticulum
FRD49_08150	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FRD49_08165	COG4890	Cyd operon protein YbgT
FRD49_08170	COG1294	oxidase, subunit
FRD49_08185	COG1585	Membrane protein implicated in regulation of membrane protease activity
FRD49_08195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FRD49_08200	COG4774	siderophore transport
FRD49_08215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FRD49_08220	COG0569	domain protein
FRD49_08225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FRD49_08255	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FRD49_08260	COG0542	response to heat
FRD49_08270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FRD49_08285	COG1902	pentaerythritol trinitrate reductase activity
FRD49_08285	COG0446	pyridine nucleotide-disulphide oxidoreductase
FRD49_08330	COG2323	membrane
FRD49_08340	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FRD49_08350	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FRD49_08355	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FRD49_08360	COG0183	Belongs to the thiolase family
FRD49_08365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FRD49_08370	COG0596	Alpha beta hydrolase
FRD49_08375	COG2271	Major facilitator Superfamily
FRD49_08380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FRD49_08385	COG3485	protocatechuate 3,4-dioxygenase
FRD49_08390	COG3485	protocatechuate 3,4-dioxygenase
FRD49_08395	COG0710	3-dehydroquinate dehydratase activity
FRD49_08400	COG3420	alginic acid biosynthetic process
FRD49_08405	COG3659	wide pore channel activity
FRD49_08410	COG4993	Dehydrogenase
FRD49_08420	COG2391	methyltransferase activity
FRD49_08435	COG1414	Transcriptional regulator
FRD49_08440	COG0583	DNA-binding transcription factor activity
FRD49_08445	COG1960	acyl-CoA dehydrogenase activity
FRD49_08470	COG2814	Major facilitator Superfamily
FRD49_08480	COG0154	amidase activity
FRD49_08500	COG4638	Rieske (2fe-2S)
FRD49_08510	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_08520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRD49_08530	COG3733	amine oxidase
FRD49_08540	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_08550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FRD49_08555	COG0183	Belongs to the thiolase family
FRD49_08560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FRD49_08565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FRD49_08575	COG4829	muconolactone delta-isomerase
FRD49_08580	COG4948	Mandelate Racemase Muconate Lactonizing
FRD49_08585	COG0583	DNA-binding transcription factor activity
FRD49_08595	COG2186	Transcriptional regulator
FRD49_08615	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_08640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FRD49_08650	COG0789	Transcriptional regulator
FRD49_08665	COG1309	transcriptional regulator
FRD49_08680	COG1309	transcriptional regulator
FRD49_08720	COG0583	DNA-binding transcription factor activity
FRD49_08735	COG1566	PFAM secretion protein HlyD family protein
FRD49_08750	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_08755	COG0129	dihydroxy-acid dehydratase activity
FRD49_08765	COG0583	DNA-binding transcription factor activity
FRD49_08770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRD49_08780	COG2084	Dehydrogenase
FRD49_08795	COG1120	ATPase activity
FRD49_08815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRD49_08910	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FRD49_08950	COG1064	alcohol dehydrogenase
FRD49_08955	COG4221	oxidoreductase activity
FRD49_08960	COG1073	alpha beta
FRD49_08980	COG1309	transcriptional regulator
FRD49_08990	COG2205	protein histidine kinase activity
FRD49_08995	COG0745	RESPONSE REGULATOR receiver
FRD49_09000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRD49_09020	COG1538	Outer membrane efflux protein
FRD49_09095	COG3539	Fimbrial protein
FRD49_09120	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FRD49_09130	COG0753	catalase activity
FRD49_09145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRD49_09210	COG4771	TonB-dependent receptor
FRD49_09215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRD49_09220	COG3433	isochorismatase activity
FRD49_09220	COG1535	isochorismatase
FRD49_09225	COG1021	2,3-dihydroxybenzoate-AMP ligase
FRD49_09230	COG1169	isochorismate synthase
FRD49_09235	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_09245	COG3251	PFAM MbtH domain protein
FRD49_09250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRD49_09280	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FRD49_09285	COG4149	molybdate abc transporter
FRD49_09290	COG0725	ABC transporter, periplasmic molybdate-binding protein
FRD49_09300	COG4638	Rieske (2fe-2S)
FRD49_09305	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FRD49_09310	COG0543	2 iron, 2 sulfur cluster binding
FRD49_09310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRD49_09325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRD49_09335	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_09340	COG0412	Dienelactone hydrolase
FRD49_09345	COG2271	Major facilitator Superfamily
FRD49_09350	COG2207	Transcriptional regulator
FRD49_09355	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_09360	COG2610	gluconate transmembrane transporter activity
FRD49_09365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRD49_09395	COG0583	DNA-binding transcription factor activity
FRD49_09415	COG0583	DNA-binding transcription factor activity
FRD49_09430	COG2031	fatty acid transporter
FRD49_09435	COG0183	Belongs to the thiolase family
FRD49_09440	COG0583	DNA-binding transcription factor activity
FRD49_09445	COG0583	DNA-binding transcription factor activity
FRD49_09460	COG1027	Aspartate ammonia-lyase
FRD49_09470	COG0477	Major facilitator Superfamily
FRD49_09490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRD49_09495	COG4521	taurine ABC transporter
FRD49_09520	COG3708	Transcriptional regulator
FRD49_09520	COG2207	Transcriptional regulator
FRD49_09535	COG0730	response to heat
FRD49_09545	COG3453	Protein conserved in bacteria
FRD49_09545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRD49_09555	COG3781	membrane
FRD49_09560	COG1063	alcohol dehydrogenase
FRD49_09570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRD49_09575	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRD49_09580	COG0022	dehydrogenase e1 component
FRD49_09585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FRD49_09590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRD49_09605	COG3706	GGDEF domain
FRD49_09620	COG0133	tryptophan synthase activity
FRD49_09630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRD49_09665	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FRD49_09690	COG2226	methyltransferase
FRD49_09740	COG0842	Transport permease protein
FRD49_09745	COG0842	Transport permease protein
FRD49_09750	COG1131	(ABC) transporter
FRD49_09770	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRD49_09775	COG4773	Receptor
FRD49_09795	COG0730	response to heat
FRD49_09800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FRD49_09810	COG4772	TonB-dependent receptor
FRD49_09825	COG0406	alpha-ribazole phosphatase activity
FRD49_09830	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FRD49_09855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FRD49_09870	COG1960	acyl-CoA dehydrogenase activity
FRD49_09875	COG1960	acyl-CoA dehydrogenase activity
FRD49_09880	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRD49_09885	COG2207	Transcriptional regulator
FRD49_09890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRD49_09895	COG0776	regulation of translation
FRD49_09920	COG0822	iron-sulfur transferase activity
FRD49_09925	COG0316	Belongs to the HesB IscA family
FRD49_09955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FRD49_09975	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FRD49_09980	COG0702	epimerase
FRD49_10010	COG4172	Belongs to the ABC transporter superfamily
FRD49_10015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FRD49_10020	COG0601	transmembrane transport
FRD49_10025	COG0339	signal peptide processing
FRD49_10050	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FRD49_10075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FRD49_10080	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FRD49_10095	COG2431	L-lysine efflux transmembrane transporter activity
FRD49_10110	COG0776	regulation of translation
FRD49_10130	COG0590	tRNA wobble adenosine to inosine editing
FRD49_10175	COG0084	hydrolase, TatD family'
FRD49_10195	COG1663	tetraacyldisaccharide 4'-kinase activity
FRD49_10200	COG1132	(ABC) transporter
FRD49_10210	COG0811	peptide transport
FRD49_10215	COG1475	DNA binding
FRD49_10220	COG1192	Involved in chromosome partitioning
FRD49_10230	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FRD49_10245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRD49_10250	COG0191	fructose-bisphosphate aldolase activity
FRD49_10270	COG0424	maF-like protein
FRD49_10275	COG2850	peptidyl-arginine hydroxylation
FRD49_10285	COG0640	Transcriptional regulator
FRD49_10295	COG3619	membrane
FRD49_10300	COG3122	Protein conserved in bacteria
FRD49_10305	COG1132	(ABC) transporter
FRD49_10325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FRD49_10330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FRD49_10345	COG0506	proline dehydrogenase activity
FRD49_10345	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FRD49_10345	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FRD49_10350	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FRD49_10365	COG3698	Phosphodiester glycosidase
FRD49_10375	COG2353	YceI-like domain
FRD49_10395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FRD49_10435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FRD49_10435	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FRD49_10460	COG3539	Fimbrial protein
FRD49_10465	COG3121	Chaperone
FRD49_10505	COG0697	spore germination
FRD49_10515	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FRD49_10525	COG0583	DNA-binding transcription factor activity
FRD49_10545	COG1309	transcriptional regulator
FRD49_10560	COG1522	sequence-specific DNA binding
FRD49_10570	COG1126	abc transporter atp-binding protein
FRD49_10575	COG0765	amino acid transport
FRD49_10580	COG0765	amino acid transport
FRD49_10610	COG1464	Belongs to the NlpA lipoprotein family
FRD49_10615	COG1464	Belongs to the NlpA lipoprotein family
FRD49_10620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FRD49_10625	COG2011	ABC-type metal ion transport system permease component
FRD49_10630	COG0012	GTP binding
FRD49_10655	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FRD49_10685	COG1280	lysine exporter protein (LysE YggA)
FRD49_10695	COG0386	Belongs to the glutathione peroxidase family
FRD49_10705	COG0436	Aminotransferase
FRD49_10710	COG1301	dicarboxylic acid transport
FRD49_10745	COG3634	alkyl hydroperoxide reductase activity
FRD49_10760	COG0583	DNA-binding transcription factor activity
FRD49_10765	COG0798	PFAM Bile acid sodium symporter
FRD49_10770	COG0640	Transcriptional regulator
FRD49_10795	COG0583	DNA-binding transcription factor activity
FRD49_10805	COG1953	Uracil, thiamine, allantoin
FRD49_10815	COG2175	clavaminate synthase activity
FRD49_10820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRD49_10825	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FRD49_10830	COG4521	taurine ABC transporter
FRD49_10840	COG0477	Major facilitator Superfamily
FRD49_10865	COG1271	oxidase subunit
FRD49_10870	COG1294	oxidase, subunit
FRD49_10880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRD49_10900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FRD49_10920	COG3052	prosthetic group binding
FRD49_10925	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FRD49_10945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRD49_10950	COG1346	cytolysis
FRD49_10960	COG0583	DNA-binding transcription factor activity
FRD49_10965	COG0625	glutathione transferase activity
FRD49_10970	COG0625	glutathione transferase activity
FRD49_10975	COG0583	DNA-binding transcription factor activity
FRD49_10990	COG1045	serine acetyltransferase
FRD49_10995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRD49_11000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FRD49_11005	COG1280	lysine exporter protein (LysE YggA)
FRD49_11020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRD49_11025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRD49_11030	COG1126	abc transporter atp-binding protein
FRD49_11035	COG0765	amino acid transport
FRD49_11040	COG0765	amino acid transport
FRD49_11060	COG2205	protein histidine kinase activity
FRD49_11060	COG0784	Response regulator, receiver
FRD49_11105	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_11155	COG0583	DNA-binding transcription factor activity
FRD49_11175	COG0318	PFAM AMP-dependent synthetase and ligase
FRD49_11180	COG1309	transcriptional regulator
FRD49_11185	COG1960	acyl-CoA dehydrogenase activity
FRD49_11190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FRD49_11195	COG1024	Enoyl-CoA hydratase
FRD49_11210	COG0583	DNA-binding transcription factor activity
FRD49_11225	COG1960	acyl-CoA dehydrogenase activity
FRD49_11235	COG2814	Major facilitator Superfamily
FRD49_11245	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FRD49_11250	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FRD49_11255	COG2814	Major facilitator Superfamily
FRD49_11260	COG1960	acyl-CoA dehydrogenase activity
FRD49_11265	COG1024	Enoyl-CoA hydratase
FRD49_11270	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_11275	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRD49_11280	COG0183	Belongs to the thiolase family
FRD49_11290	COG2814	Major facilitator Superfamily
FRD49_11300	COG1024	Enoyl-CoA hydratase
FRD49_11315	COG1960	acyl-CoA dehydrogenase activity
FRD49_11320	COG2814	Major facilitator Superfamily
FRD49_11325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FRD49_11345	COG3842	ATPase activity
FRD49_11350	COG1840	ABC-type Fe3 transport system, periplasmic component
FRD49_11360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRD49_11365	COG1414	Transcriptional regulator
FRD49_11375	COG0583	DNA-binding transcription factor activity
FRD49_11410	COG0477	Major facilitator Superfamily
FRD49_11425	COG1116	anion transmembrane transporter activity
FRD49_11430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRD49_11440	COG0864	Transcriptional regulator
FRD49_11450	COG1733	regulation of RNA biosynthetic process
FRD49_11455	COG2249	NAD(P)H dehydrogenase (quinone) activity
FRD49_11460	COG0439	Biotin carboxylase
FRD49_11475	COG1063	alcohol dehydrogenase
FRD49_11515	COG3293	Transposase
FRD49_11555	COG0038	chloride channel
FRD49_11560	COG4770	biotin carboxylase activity
FRD49_11580	COG1914	H( )-stimulated, divalent metal cation uptake system
FRD49_11585	COG0583	DNA-binding transcription factor activity
FRD49_11595	COG1595	DNA-templated transcription, initiation
FRD49_11605	COG3220	belongs to the UPF0276 family
FRD49_11620	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_11635	COG2076	Multidrug Resistance protein
FRD49_11650	COG3713	MltA-interacting MipA family protein
FRD49_11655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRD49_11730	COG1011	Hydrolase
FRD49_11750	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRD49_11765	COG0789	Transcriptional regulator
FRD49_11770	COG1278	Cold shock
FRD49_11780	COG0626	cystathionine gamma-synthase activity
FRD49_11790	COG1522	sequence-specific DNA binding
FRD49_11795	COG3123	guanosine phosphorylase activity
FRD49_11805	COG4774	siderophore transport
FRD49_11825	COG2814	Major facilitator Superfamily
FRD49_11875	COG1960	acyl-CoA dehydrogenase activity
FRD49_11885	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_11890	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_11895	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_11910	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FRD49_11950	COG1538	Outer membrane efflux protein
FRD49_11955	COG1137	ATPase activity
FRD49_11960	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FRD49_11970	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FRD49_11975	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FRD49_11975	COG0517	IMP dehydrogenase activity
FRD49_12055	COG1280	lysine exporter protein (LysE YggA)
FRD49_12085	COG1570	exodeoxyribonuclease VII activity
FRD49_12170	COG2871	sodium ion transport
FRD49_12180	COG0583	DNA-binding transcription factor activity
FRD49_12185	COG4638	Rieske (2fe-2S)
FRD49_12190	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FRD49_12195	COG0543	2 iron, 2 sulfur cluster binding
FRD49_12195	COG0633	Ferredoxin
FRD49_12200	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_12205	COG3135	benzoate transporter
FRD49_12210	COG2814	Major facilitator Superfamily
FRD49_12225	COG1643	Atp-dependent helicase
FRD49_12230	COG0450	alkyl hydroperoxide reductase
FRD49_12250	COG3634	alkyl hydroperoxide reductase activity
FRD49_12270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FRD49_12290	COG0625	glutathione transferase activity
FRD49_12300	COG2885	chlorophyll binding
FRD49_12335	COG0542	response to heat
FRD49_12350	COG1765	OsmC-like protein
FRD49_12360	COG0667	Aldo Keto reductase
FRD49_12375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FRD49_12395	COG0582	viral genome integration into host DNA
FRD49_12455	COG3293	Transposase
FRD49_12555	COG3567	Phage-associated protein, HI1409 family
FRD49_12560	COG5410	chromosome segregation
FRD49_12710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FRD49_12720	COG3038	cytochrome b561
FRD49_12725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FRD49_12730	COG2252	PERMEase
FRD49_12740	COG2072	flavoprotein involved in K transport
FRD49_12755	COG1741	Belongs to the pirin family
FRD49_12760	COG1309	transcriptional regulator
FRD49_12775	COG2072	flavoprotein involved in K transport
FRD49_12780	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FRD49_12810	COG1944	ATP diphosphatase activity
FRD49_12830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRD49_12845	COG2814	Major facilitator Superfamily
FRD49_12850	COG1024	Enoyl-CoA hydratase
FRD49_12855	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_12865	COG1960	acyl-CoA dehydrogenase activity
FRD49_12905	COG1113	amino acid transport
FRD49_12925	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_12945	COG0531	amino acid
FRD49_12955	COG1113	amino acid transport
FRD49_13040	COG3209	COG3209 Rhs family protein
FRD49_13045	COG3501	Rhs element vgr protein
FRD49_13090	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FRD49_13100	COG1230	cation diffusion facilitator family transporter
FRD49_13115	COG2814	Major facilitator Superfamily
FRD49_13220	COG0582	viral genome integration into host DNA
FRD49_13230	COG0446	pyridine nucleotide-disulphide oxidoreductase
FRD49_13230	COG1902	pentaerythritol trinitrate reductase activity
FRD49_13245	COG2203	Gaf domain
FRD49_13245	COG5001	Diguanylate cyclase
FRD49_13245	COG4251	negative regulation of phosphorylation
FRD49_13245	COG3706	GGDEF domain
FRD49_13255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FRD49_13280	COG4172	Belongs to the ABC transporter superfamily
FRD49_13285	COG4239	(ABC) transporter, permease
FRD49_13290	COG4174	ABC transporter (Permease)
FRD49_13300	COG0741	lytic transglycosylase activity
FRD49_13300	COG1388	LysM domain
FRD49_13300	COG0741	lytic transglycosylase activity
FRD49_13300	COG1388	LysM domain
FRD49_13305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FRD49_13340	COG0583	DNA-binding transcription factor activity
FRD49_13345	COG1279	arginine transmembrane transporter activity
FRD49_13365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRD49_13370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRD49_13375	COG0006	proline dipeptidase activity
FRD49_13410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FRD49_13440	COG3384	dioxygenase
FRD49_13450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FRD49_13455	COG2878	Part of a membrane complex involved in electron transport
FRD49_13460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FRD49_13485	COG0768	penicillin binding
FRD49_13490	COG0742	ribosomal rna small subunit methyltransferase
FRD49_13510	COG0830	nickel cation binding
FRD49_13520	COG0804	urea catabolic process
FRD49_13565	COG1253	flavin adenine dinucleotide binding
FRD49_13570	COG2851	Citrate transporter
FRD49_13625	COG1773	rubredoxin
FRD49_13630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRD49_13640	COG0583	DNA-binding transcription factor activity
FRD49_13665	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FRD49_13670	COG4181	ATPase activity
FRD49_13745	COG0306	phosphate transporter
FRD49_13770	COG2223	nitrite transmembrane transporter activity
FRD49_13775	COG2207	Transcriptional regulator
FRD49_13775	COG0662	Cupin 2, conserved barrel domain protein
FRD49_13780	COG2066	Belongs to the glutaminase family
FRD49_13785	COG0242	peptide deformylase activity
FRD49_13790	COG0477	Major facilitator Superfamily
FRD49_13800	COG0028	Belongs to the TPP enzyme family
FRD49_13815	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_13820	COG2267	carboxylic ester hydrolase activity
FRD49_13830	COG2271	Major facilitator Superfamily
FRD49_13835	COG0446	pyridine nucleotide-disulphide oxidoreductase
FRD49_13845	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_13865	COG1414	Transcriptional regulator
FRD49_13880	COG1024	Enoyl-CoA hydratase
FRD49_13890	COG1215	transferase activity, transferring glycosyl groups
FRD49_13895	COG0726	polysaccharide deacetylase
FRD49_13895	COG1649	PFAM Uncharacterised BCR, COG1649
FRD49_13905	COG4681	YaeQ
FRD49_13915	COG0523	cobalamin synthesis protein
FRD49_13925	COG1607	acyl-coa hydrolase
FRD49_13935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FRD49_13940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FRD49_13945	COG1309	transcriptional regulator
FRD49_13970	COG2040	homocysteine
FRD49_13975	COG0531	amino acid
FRD49_13995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRD49_14000	COG0477	Major facilitator Superfamily
FRD49_14030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FRD49_14035	COG3586	endonuclease activity
FRD49_14080	COG0405	Gamma-glutamyltransferase
FRD49_14085	COG2814	Major facilitator Superfamily
FRD49_14095	COG2050	protein possibly involved in aromatic compounds catabolism
FRD49_14110	COG1090	epimerase
FRD49_14130	COG0420	3'-5' exonuclease activity
FRD49_14140	COG1968	undecaprenyl-diphosphatase activity
FRD49_14160	COG0735	belongs to the Fur family
FRD49_14165	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRD49_14170	COG2914	Belongs to the UPF0125 (RnfH) family
FRD49_14190	COG0121	glutamine amidotransferase
FRD49_14205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRD49_14215	COG0210	DNA helicase
FRD49_14220	COG2885	chlorophyll binding
FRD49_14225	COG0204	Acyl-transferase
FRD49_14240	COG2894	cell division
FRD49_14255	COG1280	lysine exporter protein (LysE YggA)
FRD49_14260	COG1674	ftsk spoiiie
FRD49_14265	COG0492	ferredoxin-NADP+ reductase activity
FRD49_14270	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FRD49_14280	COG0456	acetyltransferase
FRD49_14310	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FRD49_14340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FRD49_14340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FRD49_14360	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_14365	COG4638	Rieske (2fe-2S)
FRD49_14380	COG0473	3-isopropylmalate dehydrogenase activity
FRD49_14385	COG0583	DNA-binding transcription factor activity
FRD49_14405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FRD49_14440	COG0358	DNA primase activity
FRD49_14455	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FRD49_14485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRD49_14525	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FRD49_14535	COG0352	thiamine-phosphate diphosphorylase activity
FRD49_14535	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FRD49_14535	COG0351	phosphomethylpyrimidine kinase
FRD49_14540	COG1652	LysM domain
FRD49_14565	COG1399	metal-binding, possibly nucleic acid-binding protein
FRD49_14570	COG3101	peptidyl-lysine hydroxylation
FRD49_14575	COG0009	L-threonylcarbamoyladenylate synthase
FRD49_14580	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FRD49_14585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FRD49_14600	COG4106	trans-aconitate 2-methyltransferase activity
FRD49_14615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FRD49_14615	COG2226	methyltransferase
FRD49_14615	COG0596	Alpha beta hydrolase
FRD49_14620	COG1877	trehalose-phosphatase activity
FRD49_14625	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FRD49_14630	COG2223	nitrite transmembrane transporter activity
FRD49_14650	COG1196	nuclear chromosome segregation
FRD49_14660	COG0730	response to heat
FRD49_14675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FRD49_14740	COG0489	protein tyrosine kinase activity
FRD49_14755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRD49_14755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRD49_14790	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FRD49_14795	COG2081	HI0933 family
FRD49_14805	COG0668	transmembrane transport
FRD49_14825	COG0583	DNA-binding transcription factor activity
FRD49_14850	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRD49_14855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRD49_14885	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FRD49_14920	COG2205	protein histidine kinase activity
FRD49_14925	COG0745	RESPONSE REGULATOR receiver
FRD49_14945	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FRD49_14955	COG0384	phenazine biosynthesis protein PhzF
FRD49_14980	COG2801	Transposase and inactivated derivatives
FRD49_15005	COG1309	transcriptional regulator
FRD49_15015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRD49_15020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FRD49_15030	COG0583	DNA-binding transcription factor activity
FRD49_15040	COG0583	DNA-binding transcription factor activity
FRD49_15060	COG0583	DNA-binding transcription factor activity
FRD49_15065	COG1053	succinate dehydrogenase
FRD49_15090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FRD49_15095	COG2814	Major facilitator Superfamily
FRD49_15100	COG1960	acyl-CoA dehydrogenase activity
FRD49_15105	COG0583	DNA-binding transcription factor activity
FRD49_15110	COG1063	alcohol dehydrogenase
FRD49_15140	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FRD49_15145	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FRD49_15150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FRD49_15170	COG2132	Multicopper oxidase
FRD49_15180	COG0561	phosphatase activity
FRD49_15185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FRD49_15210	COG1214	PFAM Peptidase M22, glycoprotease
FRD49_15260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FRD49_15270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FRD49_15275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FRD49_15280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FRD49_15340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FRD49_15350	COG1846	Transcriptional regulator
FRD49_15355	COG1764	response to oxidative stress
FRD49_15380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRD49_15380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRD49_15395	COG0037	tRNA processing
FRD49_15405	COG0248	Ppx GppA phosphatase
FRD49_15435	COG0072	phenylalanine-tRNA ligase activity
FRD49_15460	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FRD49_15465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FRD49_15485	COG1238	metal cluster binding
FRD49_15490	COG0625	glutathione transferase activity
FRD49_15505	COG0318	PFAM AMP-dependent synthetase and ligase
FRD49_15510	COG3028	Belongs to the UPF0307 family
FRD49_15515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FRD49_15535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FRD49_15540	COG0617	tRNA 3'-terminal CCA addition
FRD49_15545	COG1555	photosystem II stabilization
FRD49_15550	COG3956	TIGRFAM MazG family protein
FRD49_15560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FRD49_15580	COG0784	Response regulator, receiver
FRD49_15580	COG2205	protein histidine kinase activity
FRD49_15580	COG5002	protein histidine kinase activity
FRD49_15585	COG1024	Enoyl-CoA hydratase
FRD49_15590	COG2084	Dehydrogenase
FRD49_15595	COG3622	Belongs to the hyi family
FRD49_15610	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FRD49_15615	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FRD49_15620	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FRD49_15625	COG0697	spore germination
FRD49_15635	COG2814	Major facilitator Superfamily
FRD49_15655	COG2132	Multicopper oxidase
FRD49_15670	COG2205	protein histidine kinase activity
FRD49_15760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FRD49_15780	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FRD49_15790	COG0084	hydrolase, TatD family'
FRD49_15805	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FRD49_15835	COG0440	acetolactate synthase activity
FRD49_15840	COG0028	Belongs to the TPP enzyme family
FRD49_15865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRD49_15870	COG0577	efflux transmembrane transporter activity
FRD49_15870	COG1136	(ABC) transporter
FRD49_15875	COG1538	Outer membrane efflux protein
FRD49_15890	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FRD49_15895	COG1162	GTPase activity
FRD49_15905	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FRD49_15925	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRD49_15945	COG1426	Protein conserved in bacteria
FRD49_15980	COG0793	Belongs to the peptidase S41A family
FRD49_15995	COG2267	carboxylic ester hydrolase activity
FRD49_16005	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_16010	COG3265	gluconokinase activity
FRD49_16020	COG0800	Aldolase
FRD49_16030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FRD49_16035	COG0280	phosphate acetyltransferase
FRD49_16035	COG0857	belongs to the CobB CobQ family
FRD49_16040	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FRD49_16040	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FRD49_16060	COG0740	serine-type endopeptidase activity
FRD49_16070	COG4774	siderophore transport
FRD49_16080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FRD49_16090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FRD49_16090	COG2813	Specifically methylates the guanine in position
FRD49_16195	COG0788	formyltetrahydrofolate deformylase activity
FRD49_16210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FRD49_16215	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FRD49_16220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FRD49_16220	COG4651	solute:proton antiporter activity
FRD49_16240	COG0724	RNA recognition motif
FRD49_16245	COG0210	DNA helicase
FRD49_16270	COG1733	regulation of RNA biosynthetic process
FRD49_16280	COG2900	Belongs to the SlyX family
FRD49_16295	COG1280	lysine exporter protein (LysE YggA)
FRD49_16300	COG1560	Kdo2-lipid A biosynthetic process
FRD49_16310	COG1301	dicarboxylic acid transport
FRD49_16365	COG0473	3-isopropylmalate dehydrogenase activity
FRD49_16390	COG0583	DNA-binding transcription factor activity
FRD49_16435	COG0583	DNA-binding transcription factor activity
FRD49_16445	COG0625	glutathione transferase activity
FRD49_16450	COG2378	regulation of single-species biofilm formation
FRD49_16470	COG1530	ribonuclease E activity
FRD49_16490	COG0583	DNA-binding transcription factor activity
FRD49_16495	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_16500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FRD49_16510	COG0534	Mate efflux family protein
FRD49_16525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FRD49_16570	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FRD49_16575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRD49_16590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FRD49_16600	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FRD49_16600	COG0644	oxidoreductase
FRD49_16615	COG4535	Mg2 and Co2 transporter CorC
FRD49_16625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRD49_16650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FRD49_16655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FRD49_16655	COG0475	glutathione-regulated potassium exporter activity
FRD49_16660	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FRD49_16670	COG0484	heat shock protein binding
FRD49_16675	COG0789	Transcriptional regulator
FRD49_16680	COG0598	Magnesium transport protein CorA
FRD49_16685	COG1185	polyribonucleotide nucleotidyltransferase activity
FRD49_16700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FRD49_16705	COG1074	ATP-dependent DNA helicase activity
FRD49_16710	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FRD49_16735	COG2226	methyltransferase
FRD49_16745	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FRD49_16760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FRD49_16775	COG2111	Na H antiporter
FRD49_16775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRD49_16780	COG1006	Multisubunit Na H antiporter MnhC subunit
FRD49_16785	COG0651	ATP synthesis coupled electron transport
FRD49_16795	COG2212	antiporter activity
FRD49_16805	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FRD49_16815	COG0195	Participates in both transcription termination and antitermination
FRD49_16865	COG0237	dephospho-CoA kinase activity
FRD49_16875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRD49_16890	COG0497	DNA recombination
FRD49_16900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FRD49_16915	COG1289	transmembrane transporter activity
FRD49_16930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FRD49_16930	COG2169	Transcriptional regulator
FRD49_16935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FRD49_16985	COG3545	Serine hydrolase
FRD49_17000	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FRD49_17015	COG0326	Molecular chaperone. Has ATPase activity
FRD49_17030	COG2056	Na+-H+ antiporter family
FRD49_17035	COG0596	Alpha beta hydrolase
FRD49_17135	COG0546	phosphoglycolate phosphatase activity
FRD49_17140	COG1716	ATPase activity
FRD49_17185	COG0181	hydroxymethylbilane synthase activity
FRD49_17195	COG3275	phosphorelay sensor kinase activity
FRD49_17215	COG1538	Outer membrane efflux protein
FRD49_17245	COG0494	nUDIX hydrolase
FRD49_17250	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FRD49_17255	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FRD49_17260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRD49_17265	COG0772	Belongs to the SEDS family
FRD49_17290	COG4974	Belongs to the 'phage' integrase family
FRD49_17295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FRD49_17305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FRD49_17315	COG2197	response regulator
FRD49_17330	COG0793	Belongs to the peptidase S41A family
FRD49_17335	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FRD49_17340	COG0795	lipopolysaccharide-transporting ATPase activity
FRD49_17380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRD49_17380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRD49_17390	COG0004	ammonium transporteR
FRD49_17395	COG0347	Belongs to the P(II) protein family
FRD49_17405	COG0606	chelatase, subunit chli
FRD49_17410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRD49_17415	COG0235	Class ii aldolase
FRD49_17420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRD49_17435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FRD49_17450	COG0318	PFAM AMP-dependent synthetase and ligase
FRD49_17460	COG0477	Major facilitator Superfamily
FRD49_17465	COG2860	membrane
FRD49_17475	COG1253	flavin adenine dinucleotide binding
FRD49_17485	COG2814	Major facilitator Superfamily
FRD49_17495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FRD49_17530	COG0655	NAD(P)H dehydrogenase (quinone) activity
FRD49_17545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FRD49_17580	COG1309	transcriptional regulator
FRD49_17615	COG0758	DNA mediated transformation
FRD49_17625	COG0697	spore germination
FRD49_17630	COG1309	transcriptional regulator
FRD49_17645	COG0386	Belongs to the glutathione peroxidase family
FRD49_17655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FRD49_17710	COG1121	(ABC) transporter
FRD49_17715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FRD49_17720	COG1280	lysine exporter protein (LysE YggA)
FRD49_17725	COG2837	iron assimilation
FRD49_17730	COG0281	malic enzyme
FRD49_17770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FRD49_17775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FRD49_17775	COG0519	Catalyzes the synthesis of GMP from XMP
FRD49_17780	COG4399	Belongs to the UPF0754 family
FRD49_17785	COG2259	Doxx family
FRD49_17790	COG0586	Pfam SNARE associated Golgi protein
FRD49_17805	COG1192	Involved in chromosome partitioning
FRD49_17815	COG0271	Belongs to the BolA IbaG family
FRD49_17860	COG1960	acyl-CoA dehydrogenase activity
FRD49_17865	COG0318	PFAM AMP-dependent synthetase and ligase
FRD49_17870	COG2197	response regulator
FRD49_17880	COG3916	Acyl-homoserine-lactone synthase
FRD49_17885	COG0477	Major facilitator Superfamily
FRD49_17890	COG1024	Enoyl-CoA hydratase
FRD49_17895	COG1024	Enoyl-CoA hydratase
FRD49_17900	COG1960	acyl-CoA dehydrogenase activity
FRD49_17905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRD49_17925	COG1113	amino acid transport
FRD49_17930	COG1113	amino acid transport
FRD49_17935	COG0251	oxidation-reduction process
FRD49_17950	COG1522	sequence-specific DNA binding
FRD49_17975	COG0564	pseudouridine synthase activity
FRD49_18040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FRD49_18055	COG1802	Transcriptional regulator
FRD49_18065	COG1448	Aminotransferase
FRD49_18070	COG0277	FAD linked oxidase domain protein
FRD49_18080	COG2186	Transcriptional regulator
FRD49_18090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRD49_18120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FRD49_18125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FRD49_18150	COG0463	Glycosyl transferase, family 2
FRD49_18175	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FRD49_18180	COG1091	dTDP-4-dehydrorhamnose reductase activity
FRD49_18190	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FRD49_18195	COG1596	polysaccharide export
FRD49_18220	COG0728	peptidoglycan biosynthetic process
FRD49_18225	COG3023	N-Acetylmuramoyl-L-alanine amidase
FRD49_18280	COG0546	phosphoglycolate phosphatase activity
FRD49_18285	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_18300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FRD49_18300	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FRD49_18305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRD49_18310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRD49_18315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRD49_18320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRD49_18325	COG1116	anion transmembrane transporter activity
FRD49_18330	COG1309	transcriptional regulator
FRD49_18335	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FRD49_18345	COG0196	riboflavin kinase activity
FRD49_18350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FRD49_18360	COG1047	Peptidyl-prolyl cis-trans
FRD49_18400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FRD49_18455	COG2951	lytic endotransglycosylase activity
FRD49_18460	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FRD49_18480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FRD49_18490	COG0671	phosphoesterase, PA-phosphatase related
FRD49_18495	COG0861	Integral membrane protein TerC family
FRD49_18505	COG0754	glutathionylspermidine amidase activity
FRD49_18515	COG0402	S-adenosylhomocysteine deaminase activity
FRD49_18530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FRD49_18535	COG1230	cation diffusion facilitator family transporter
FRD49_18550	COG0706	membrane insertase activity
FRD49_18565	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FRD49_18610	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
FRD49_18620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FRD49_18650	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
FRD49_18675	COG2801	Transposase and inactivated derivatives
FRD49_18705	COG4221	oxidoreductase activity
FRD49_18710	COG0583	DNA-binding transcription factor activity
FRD49_18715	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FRD49_18720	COG0604	alcohol dehydrogenase
FRD49_18720	COG3321	synthase
FRD49_18730	COG0697	spore germination
FRD49_18735	COG0477	Major facilitator Superfamily
FRD49_18765	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FRD49_18780	COG1979	alcohol dehydrogenase
FRD49_18790	COG1902	pentaerythritol trinitrate reductase activity
FRD49_18800	COG1309	transcriptional regulator
FRD49_18805	COG2130	NADP-dependent
FRD49_18820	COG0582	viral genome integration into host DNA
FRD49_18840	COG3293	Transposase
FRD49_18855	COG0542	response to heat
FRD49_18885	COG0501	Belongs to the peptidase M48B family
FRD49_18890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRD49_18930	COG1064	alcohol dehydrogenase
FRD49_18985	COG1192	Involved in chromosome partitioning
FRD49_19010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs