locus-tag	class	description
H0S59_00010	COG0592	DNA-directed DNA polymerase activity
H0S59_00020	COG0187	DNA topoisomerase II activity
H0S59_00030	COG0586	Pfam SNARE associated Golgi protein
H0S59_00035	COG0488	(ABC) transporter
H0S59_00060	COG0596	Alpha beta hydrolase
H0S59_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H0S59_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0S59_00110	COG1047	Peptidyl-prolyl cis-trans
H0S59_00120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0S59_00125	COG0196	riboflavin kinase activity
H0S59_00135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H0S59_00140	COG1309	transcriptional regulator
H0S59_00145	COG1116	anion transmembrane transporter activity
H0S59_00150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S59_00155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S59_00160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S59_00165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S59_00170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H0S59_00170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0S59_00185	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_00190	COG0546	phosphoglycolate phosphatase activity
H0S59_00245	COG3023	N-Acetylmuramoyl-L-alanine amidase
H0S59_00250	COG0728	peptidoglycan biosynthetic process
H0S59_00275	COG1596	polysaccharide export
H0S59_00280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H0S59_00290	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H0S59_00305	COG2030	dehydratase
H0S59_00320	COG0463	Glycosyl transferase, family 2
H0S59_00320	COG1216	Glycosyl transferase, family 2
H0S59_00325	COG0297	glycogen (starch) synthase activity
H0S59_00325	COG0438	transferase activity, transferring glycosyl groups
H0S59_00335	COG1215	transferase activity, transferring glycosyl groups
H0S59_00345	COG1216	Glycosyl transferase, family 2
H0S59_00350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0S59_00355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H0S59_00370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S59_00400	COG2186	Transcriptional regulator
H0S59_00410	COG0277	FAD linked oxidase domain protein
H0S59_00415	COG1448	Aminotransferase
H0S59_00425	COG1802	Transcriptional regulator
H0S59_00440	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H0S59_00540	COG0564	pseudouridine synthase activity
H0S59_00580	COG0251	oxidation-reduction process
H0S59_00585	COG1113	amino acid transport
H0S59_00590	COG1113	amino acid transport
H0S59_00610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S59_00615	COG1960	acyl-CoA dehydrogenase activity
H0S59_00620	COG1024	Enoyl-CoA hydratase
H0S59_00625	COG1024	Enoyl-CoA hydratase
H0S59_00630	COG0477	Major facilitator Superfamily
H0S59_00635	COG3916	Acyl-homoserine-lactone synthase
H0S59_00645	COG2197	response regulator
H0S59_00650	COG0318	PFAM AMP-dependent synthetase and ligase
H0S59_00655	COG1960	acyl-CoA dehydrogenase activity
H0S59_00700	COG0271	Belongs to the BolA IbaG family
H0S59_00710	COG1192	Involved in chromosome partitioning
H0S59_00725	COG0586	Pfam SNARE associated Golgi protein
H0S59_00730	COG2259	Doxx family
H0S59_00735	COG4399	Belongs to the UPF0754 family
H0S59_00740	COG0519	Catalyzes the synthesis of GMP from XMP
H0S59_00740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0S59_00745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0S59_00755	COG0735	belongs to the Fur family
H0S59_00790	COG0281	malic enzyme
H0S59_00795	COG2837	iron assimilation
H0S59_00800	COG1280	lysine exporter protein (LysE YggA)
H0S59_00805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0S59_00810	COG1121	(ABC) transporter
H0S59_00865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H0S59_00875	COG0386	Belongs to the glutathione peroxidase family
H0S59_00890	COG1309	transcriptional regulator
H0S59_00895	COG0697	spore germination
H0S59_00905	COG0758	DNA mediated transformation
H0S59_00940	COG1309	transcriptional regulator
H0S59_00975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0S59_00990	COG0655	NAD(P)H dehydrogenase (quinone) activity
H0S59_01025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0S59_01035	COG2814	Major facilitator Superfamily
H0S59_01045	COG1253	flavin adenine dinucleotide binding
H0S59_01055	COG2860	membrane
H0S59_01060	COG0477	Major facilitator Superfamily
H0S59_01070	COG0318	PFAM AMP-dependent synthetase and ligase
H0S59_01085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H0S59_01100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S59_01105	COG0235	Class ii aldolase
H0S59_01110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S59_01115	COG0606	chelatase, subunit chli
H0S59_01165	COG2205	protein histidine kinase activity
H0S59_01180	COG2132	Multicopper oxidase
H0S59_01225	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S59_01250	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H0S59_01280	COG0606	chelatase, subunit chli
H0S59_01290	COG0347	Belongs to the P(II) protein family
H0S59_01295	COG0004	ammonium transporteR
H0S59_01305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0S59_01305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0S59_01345	COG0795	lipopolysaccharide-transporting ATPase activity
H0S59_01350	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0S59_01355	COG0793	Belongs to the peptidase S41A family
H0S59_01370	COG2197	response regulator
H0S59_01380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0S59_01390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S59_01395	COG4974	Belongs to the 'phage' integrase family
H0S59_01420	COG0772	Belongs to the SEDS family
H0S59_01425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S59_01430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H0S59_01435	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0S59_01440	COG0494	nUDIX hydrolase
H0S59_01460	COG0697	spore germination
H0S59_01465	COG1538	Outer membrane efflux protein
H0S59_01485	COG3275	phosphorelay sensor kinase activity
H0S59_01495	COG0181	hydroxymethylbilane synthase activity
H0S59_01540	COG1716	ATPase activity
H0S59_01545	COG0546	phosphoglycolate phosphatase activity
H0S59_01640	COG0596	Alpha beta hydrolase
H0S59_01645	COG2056	Na+-H+ antiporter family
H0S59_01660	COG0326	Molecular chaperone. Has ATPase activity
H0S59_01675	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H0S59_01690	COG3545	Serine hydrolase
H0S59_01735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H0S59_01740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0S59_01740	COG2169	Transcriptional regulator
H0S59_01755	COG1289	transmembrane transporter activity
H0S59_01770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0S59_01780	COG0497	DNA recombination
H0S59_01795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S59_01805	COG0237	dephospho-CoA kinase activity
H0S59_01850	COG0195	Participates in both transcription termination and antitermination
H0S59_01860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H0S59_01865	COG1320	monovalent cation:proton antiporter activity
H0S59_01870	COG2212	antiporter activity
H0S59_01875	COG1863	multisubunit Na H antiporter MnhE subunit
H0S59_01880	COG0651	ATP synthesis coupled electron transport
H0S59_01885	COG1006	Multisubunit Na H antiporter MnhC subunit
H0S59_01890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0S59_01890	COG2111	Na H antiporter
H0S59_01905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0S59_01915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S59_01925	COG2226	methyltransferase
H0S59_01950	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H0S59_01955	COG1074	ATP-dependent DNA helicase activity
H0S59_01960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S59_01965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H0S59_01975	COG1185	polyribonucleotide nucleotidyltransferase activity
H0S59_01980	COG0598	Magnesium transport protein CorA
H0S59_01985	COG0789	Transcriptional regulator
H0S59_01990	COG0484	heat shock protein binding
H0S59_02000	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H0S59_02005	COG0475	glutathione-regulated potassium exporter activity
H0S59_02005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0S59_02010	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0S59_02035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S59_02045	COG4535	Mg2 and Co2 transporter CorC
H0S59_02060	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H0S59_02060	COG0644	oxidoreductase
H0S59_02070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0S59_02085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S59_02090	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H0S59_02100	COG0493	'glutamate synthase
H0S59_02100	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S59_02130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S59_02145	COG0534	Mate efflux family protein
H0S59_02155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0S59_02160	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_02165	COG0583	DNA-binding transcription factor activity
H0S59_02180	COG0318	PFAM AMP-dependent synthetase and ligase
H0S59_02185	COG1530	ribonuclease E activity
H0S59_02200	COG2378	regulation of single-species biofilm formation
H0S59_02205	COG0625	glutathione transferase activity
H0S59_02215	COG0583	DNA-binding transcription factor activity
H0S59_02285	COG0473	3-isopropylmalate dehydrogenase activity
H0S59_02340	COG1301	dicarboxylic acid transport
H0S59_02350	COG1560	Kdo2-lipid A biosynthetic process
H0S59_02355	COG1280	lysine exporter protein (LysE YggA)
H0S59_02365	COG0488	(ABC) transporter
H0S59_02370	COG2900	Belongs to the SlyX family
H0S59_02380	COG1733	regulation of RNA biosynthetic process
H0S59_02405	COG0210	DNA helicase
H0S59_02410	COG0724	RNA recognition motif
H0S59_02430	COG4651	solute:proton antiporter activity
H0S59_02430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0S59_02455	COG0788	formyltetrahydrofolate deformylase activity
H0S59_02560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S59_02560	COG2813	Specifically methylates the guanine in position
H0S59_02570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0S59_02580	COG4774	siderophore transport
H0S59_02590	COG0740	serine-type endopeptidase activity
H0S59_02610	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H0S59_02610	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H0S59_02615	COG0280	phosphate acetyltransferase
H0S59_02615	COG0857	belongs to the CobB CobQ family
H0S59_02620	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H0S59_02630	COG0800	Aldolase
H0S59_02640	COG3265	gluconokinase activity
H0S59_02645	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_02655	COG2267	carboxylic ester hydrolase activity
H0S59_02670	COG0793	Belongs to the peptidase S41A family
H0S59_02705	COG1426	Protein conserved in bacteria
H0S59_02725	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S59_02750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0S59_02760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H0S59_02765	COG1216	Glycosyl transferase, family 2
H0S59_02815	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_02820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0S59_02840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H0S59_02850	COG1162	GTPase activity
H0S59_02855	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H0S59_02870	COG1538	Outer membrane efflux protein
H0S59_02875	COG0577	efflux transmembrane transporter activity
H0S59_02875	COG1136	(ABC) transporter
H0S59_02880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S59_02905	COG0028	Belongs to the TPP enzyme family
H0S59_02910	COG0440	acetolactate synthase activity
H0S59_02945	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H0S59_02960	COG0084	hydrolase, TatD family'
H0S59_02970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H0S59_02990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0S59_02995	COG2814	Major facilitator Superfamily
H0S59_03005	COG0697	spore germination
H0S59_03035	COG3622	Belongs to the hyi family
H0S59_03040	COG2084	Dehydrogenase
H0S59_03045	COG1024	Enoyl-CoA hydratase
H0S59_03050	COG5002	protein histidine kinase activity
H0S59_03050	COG2205	protein histidine kinase activity
H0S59_03050	COG0784	Response regulator, receiver
H0S59_03070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0S59_03080	COG3956	TIGRFAM MazG family protein
H0S59_03085	COG1555	photosystem II stabilization
H0S59_03090	COG0617	tRNA 3'-terminal CCA addition
H0S59_03095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H0S59_03115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0S59_03120	COG3028	Belongs to the UPF0307 family
H0S59_03125	COG0318	PFAM AMP-dependent synthetase and ligase
H0S59_03140	COG0625	glutathione transferase activity
H0S59_03145	COG1238	metal cluster binding
H0S59_03155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H0S59_03185	COG0072	phenylalanine-tRNA ligase activity
H0S59_03215	COG0248	Ppx GppA phosphatase
H0S59_03225	COG0037	tRNA processing
H0S59_03240	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0S59_03240	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0S59_03265	COG1764	response to oxidative stress
H0S59_03270	COG1846	Transcriptional regulator
H0S59_03280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S59_03340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H0S59_03345	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0S59_03350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0S59_03360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H0S59_03410	COG1214	PFAM Peptidase M22, glycoprotease
H0S59_03435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0S59_03440	COG0561	phosphatase activity
H0S59_03450	COG2132	Multicopper oxidase
H0S59_03470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0S59_03475	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H0S59_03480	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H0S59_03510	COG1063	alcohol dehydrogenase
H0S59_03515	COG0583	DNA-binding transcription factor activity
H0S59_03520	COG1960	acyl-CoA dehydrogenase activity
H0S59_03525	COG2814	Major facilitator Superfamily
H0S59_03530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H0S59_03535	COG1309	transcriptional regulator
H0S59_03550	COG1053	succinate dehydrogenase
H0S59_03555	COG0583	DNA-binding transcription factor activity
H0S59_03570	COG0583	DNA-binding transcription factor activity
H0S59_03590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S59_03595	COG1309	transcriptional regulator
H0S59_03645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0S59_03665	COG0745	RESPONSE REGULATOR receiver
H0S59_03680	COG3706	GGDEF domain
H0S59_03705	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H0S59_03735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0S59_03740	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S59_03765	COG0583	DNA-binding transcription factor activity
H0S59_03785	COG0668	transmembrane transport
H0S59_03795	COG2081	HI0933 family
H0S59_03800	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H0S59_03835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S59_03835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S59_03845	COG0489	protein tyrosine kinase activity
H0S59_03895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0S59_03905	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0S59_03920	COG0730	response to heat
H0S59_03930	COG1196	nuclear chromosome segregation
H0S59_03950	COG2223	nitrite transmembrane transporter activity
H0S59_03955	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H0S59_03960	COG1877	trehalose-phosphatase activity
H0S59_03965	COG2226	methyltransferase
H0S59_03965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S59_03965	COG0596	Alpha beta hydrolase
H0S59_03980	COG4106	trans-aconitate 2-methyltransferase activity
H0S59_03995	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H0S59_04000	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H0S59_04005	COG0009	L-threonylcarbamoyladenylate synthase
H0S59_04010	COG3101	peptidyl-lysine hydroxylation
H0S59_04015	COG1399	metal-binding, possibly nucleic acid-binding protein
H0S59_04030	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_04040	COG1652	LysM domain
H0S59_04045	COG0351	phosphomethylpyrimidine kinase
H0S59_04045	COG0352	thiamine-phosphate diphosphorylase activity
H0S59_04045	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0S59_04055	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0S59_04085	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0S59_04115	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H0S59_04130	COG0358	DNA primase activity
H0S59_04330	COG3728	DNA packaging
H0S59_04420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H0S59_04445	COG0582	viral genome integration into host DNA
H0S59_04455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S59_04475	COG0583	DNA-binding transcription factor activity
H0S59_04480	COG0473	3-isopropylmalate dehydrogenase activity
H0S59_04490	COG0657	acetylesterase activity
H0S59_04495	COG4638	Rieske (2fe-2S)
H0S59_04500	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_04520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H0S59_04520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S59_04535	COG1981	membrane
H0S59_04550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H0S59_04580	COG0456	acetyltransferase
H0S59_04590	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H0S59_04595	COG0492	ferredoxin-NADP+ reductase activity
H0S59_04600	COG1674	ftsk spoiiie
H0S59_04605	COG1280	lysine exporter protein (LysE YggA)
H0S59_04625	COG2894	cell division
H0S59_04640	COG0204	Acyl-transferase
H0S59_04645	COG2885	chlorophyll binding
H0S59_04650	COG0210	DNA helicase
H0S59_04660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0S59_04675	COG0121	glutamine amidotransferase
H0S59_04695	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S59_04700	COG0735	belongs to the Fur family
H0S59_04720	COG1968	undecaprenyl-diphosphatase activity
H0S59_04730	COG0420	3'-5' exonuclease activity
H0S59_04750	COG1090	epimerase
H0S59_04765	COG2050	protein possibly involved in aromatic compounds catabolism
H0S59_04775	COG2814	Major facilitator Superfamily
H0S59_04780	COG0405	Gamma-glutamyltransferase
H0S59_04825	COG0477	Major facilitator Superfamily
H0S59_04830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S59_04880	COG0531	amino acid
H0S59_04885	COG2040	homocysteine
H0S59_04910	COG1309	transcriptional regulator
H0S59_04915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S59_04920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S59_04930	COG1607	acyl-coa hydrolase
H0S59_04940	COG0523	cobalamin synthesis protein
H0S59_04950	COG4681	YaeQ
H0S59_04960	COG0726	polysaccharide deacetylase
H0S59_04960	COG1649	PFAM Uncharacterised BCR, COG1649
H0S59_04965	COG1215	transferase activity, transferring glycosyl groups
H0S59_04975	COG1024	Enoyl-CoA hydratase
H0S59_05000	COG1414	Transcriptional regulator
H0S59_05020	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_05030	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S59_05035	COG2271	Major facilitator Superfamily
H0S59_05045	COG2267	carboxylic ester hydrolase activity
H0S59_05050	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_05065	COG0028	Belongs to the TPP enzyme family
H0S59_05075	COG0477	Major facilitator Superfamily
H0S59_05080	COG0242	peptide deformylase activity
H0S59_05085	COG2066	Belongs to the glutaminase family
H0S59_05090	COG0662	Cupin 2, conserved barrel domain protein
H0S59_05090	COG2207	Transcriptional regulator
H0S59_05095	COG2223	nitrite transmembrane transporter activity
H0S59_05125	COG0306	phosphate transporter
H0S59_05145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0S59_05190	COG4181	ATPase activity
H0S59_05195	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H0S59_05220	COG0583	DNA-binding transcription factor activity
H0S59_05230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S59_05235	COG1773	rubredoxin
H0S59_05285	COG2851	Citrate transporter
H0S59_05290	COG1253	flavin adenine dinucleotide binding
H0S59_05335	COG0804	urea catabolic process
H0S59_05345	COG0830	nickel cation binding
H0S59_05365	COG0742	ribosomal rna small subunit methyltransferase
H0S59_05370	COG0768	penicillin binding
H0S59_05395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0S59_05400	COG2878	Part of a membrane complex involved in electron transport
H0S59_05405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0S59_05415	COG3384	dioxygenase
H0S59_05465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0S59_05500	COG0006	proline dipeptidase activity
H0S59_05505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S59_05510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S59_05530	COG1279	arginine transmembrane transporter activity
H0S59_05535	COG0583	DNA-binding transcription factor activity
H0S59_05580	COG1388	LysM domain
H0S59_05580	COG0741	lytic transglycosylase activity
H0S59_05580	COG1388	LysM domain
H0S59_05580	COG0741	lytic transglycosylase activity
H0S59_05590	COG4174	ABC transporter (Permease)
H0S59_05595	COG4239	(ABC) transporter, permease
H0S59_05600	COG4172	Belongs to the ABC transporter superfamily
H0S59_05630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0S59_05640	COG4251	negative regulation of phosphorylation
H0S59_05640	COG2203	Gaf domain
H0S59_05640	COG5001	Diguanylate cyclase
H0S59_05640	COG3706	GGDEF domain
H0S59_05655	COG1902	pentaerythritol trinitrate reductase activity
H0S59_05655	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S59_05665	COG0582	viral genome integration into host DNA
H0S59_05680	COG2161	toxin-antitoxin pair type II binding
H0S59_05715	COG4372	Transposase
H0S59_05750	COG1309	transcriptional regulator
H0S59_05855	COG1113	amino acid transport
H0S59_05865	COG0531	amino acid
H0S59_05885	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_05905	COG1113	amino acid transport
H0S59_05925	COG0697	spore germination
H0S59_05945	COG1960	acyl-CoA dehydrogenase activity
H0S59_05955	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_05960	COG1024	Enoyl-CoA hydratase
H0S59_05965	COG2814	Major facilitator Superfamily
H0S59_05980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S59_06000	COG1944	ATP diphosphatase activity
H0S59_06030	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H0S59_06035	COG2072	flavoprotein involved in K transport
H0S59_06050	COG1309	transcriptional regulator
H0S59_06055	COG1741	Belongs to the pirin family
H0S59_06070	COG2072	flavoprotein involved in K transport
H0S59_06080	COG2252	PERMEase
H0S59_06085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H0S59_06090	COG3038	cytochrome b561
H0S59_06100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0S59_06110	COG0527	aspartate kinase activity
H0S59_06130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0S59_06145	COG0667	Aldo Keto reductase
H0S59_06155	COG1765	OsmC-like protein
H0S59_06170	COG0542	response to heat
H0S59_06205	COG2885	chlorophyll binding
H0S59_06215	COG0625	glutathione transferase activity
H0S59_06220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0S59_06240	COG3634	alkyl hydroperoxide reductase activity
H0S59_06260	COG0450	alkyl hydroperoxide reductase
H0S59_06265	COG1643	Atp-dependent helicase
H0S59_06280	COG2814	Major facilitator Superfamily
H0S59_06285	COG3135	benzoate transporter
H0S59_06290	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_06295	COG0633	Ferredoxin
H0S59_06295	COG0543	2 iron, 2 sulfur cluster binding
H0S59_06300	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H0S59_06305	COG4638	Rieske (2fe-2S)
H0S59_06310	COG0583	DNA-binding transcription factor activity
H0S59_06320	COG2871	sodium ion transport
H0S59_06405	COG1570	exodeoxyribonuclease VII activity
H0S59_06435	COG1280	lysine exporter protein (LysE YggA)
H0S59_06515	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0S59_06515	COG0517	IMP dehydrogenase activity
H0S59_06520	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H0S59_06530	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H0S59_06535	COG1137	ATPase activity
H0S59_06540	COG1538	Outer membrane efflux protein
H0S59_06570	COG4122	O-methyltransferase activity
H0S59_06580	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H0S59_06595	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_06600	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_06605	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_06615	COG1960	acyl-CoA dehydrogenase activity
H0S59_06665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S59_06670	COG0653	protein targeting
H0S59_06695	COG2814	Major facilitator Superfamily
H0S59_06715	COG4774	siderophore transport
H0S59_06720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0S59_06750	COG1522	sequence-specific DNA binding
H0S59_06760	COG0626	cystathionine gamma-synthase activity
H0S59_06770	COG1278	Cold shock
H0S59_06775	COG0789	Transcriptional regulator
H0S59_06790	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S59_06810	COG1011	Hydrolase
H0S59_06870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0S59_06875	COG3713	MltA-interacting MipA family protein
H0S59_06890	COG2076	Multidrug Resistance protein
H0S59_06905	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_06920	COG3220	belongs to the UPF0276 family
H0S59_06930	COG1595	DNA-templated transcription, initiation
H0S59_06940	COG0583	DNA-binding transcription factor activity
H0S59_06945	COG1914	H( )-stimulated, divalent metal cation uptake system
H0S59_06965	COG4770	biotin carboxylase activity
H0S59_06970	COG0038	chloride channel
H0S59_06975	COG1196	nuclear chromosome segregation
H0S59_07000	COG1063	alcohol dehydrogenase
H0S59_07015	COG0439	Biotin carboxylase
H0S59_07020	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0S59_07025	COG1733	regulation of RNA biosynthetic process
H0S59_07035	COG0864	Transcriptional regulator
H0S59_07045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0S59_07050	COG1116	anion transmembrane transporter activity
H0S59_07065	COG0477	Major facilitator Superfamily
H0S59_07125	COG2885	chlorophyll binding
H0S59_07170	COG0590	tRNA wobble adenosine to inosine editing
H0S59_07175	COG2807	transmembrane transport
H0S59_07190	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H0S59_07200	COG0789	Transcriptional regulator
H0S59_07210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S59_07230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0S59_07255	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_07260	COG0531	amino acid
H0S59_07265	COG1760	l-serine dehydratase
H0S59_07270	COG2030	dehydratase
H0S59_07270	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_07275	COG3396	Phenylacetate-CoA oxygenase
H0S59_07280	COG3460	Phenylacetate-CoA oxygenase
H0S59_07285	COG3396	Phenylacetate-CoA oxygenase
H0S59_07290	COG2151	metal-sulfur cluster biosynthetic enzyme
H0S59_07295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S59_07300	COG1024	Enoyl-CoA hydratase
H0S59_07305	COG1024	Enoyl-CoA hydratase
H0S59_07310	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S59_07315	COG0183	Belongs to the thiolase family
H0S59_07320	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H0S59_07325	COG3327	negative regulation of DNA-templated transcription, initiation
H0S59_07335	COG2050	protein possibly involved in aromatic compounds catabolism
H0S59_07355	COG1733	regulation of RNA biosynthetic process
H0S59_07360	COG0753	catalase activity
H0S59_07365	COG3038	cytochrome b561
H0S59_07385	COG2267	carboxylic ester hydrolase activity
H0S59_07390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S59_07395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S59_07400	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_07410	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H0S59_07420	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_07425	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H0S59_07430	COG0583	DNA-binding transcription factor activity
H0S59_07440	COG1414	Transcriptional regulator
H0S59_07445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S59_07455	COG1840	ABC-type Fe3 transport system, periplasmic component
H0S59_07460	COG3842	ATPase activity
H0S59_07475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H0S59_07480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0S59_07485	COG2814	Major facilitator Superfamily
H0S59_07490	COG1960	acyl-CoA dehydrogenase activity
H0S59_07505	COG1024	Enoyl-CoA hydratase
H0S59_07515	COG2814	Major facilitator Superfamily
H0S59_07525	COG0183	Belongs to the thiolase family
H0S59_07530	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S59_07535	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_07540	COG1024	Enoyl-CoA hydratase
H0S59_07545	COG1960	acyl-CoA dehydrogenase activity
H0S59_07550	COG2814	Major facilitator Superfamily
H0S59_07555	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0S59_07560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S59_07570	COG2814	Major facilitator Superfamily
H0S59_07580	COG1960	acyl-CoA dehydrogenase activity
H0S59_07595	COG0583	DNA-binding transcription factor activity
H0S59_07605	COG4770	biotin carboxylase activity
H0S59_07610	COG1024	Enoyl-CoA hydratase
H0S59_07615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0S59_07620	COG1960	acyl-CoA dehydrogenase activity
H0S59_07625	COG1309	transcriptional regulator
H0S59_07630	COG0318	PFAM AMP-dependent synthetase and ligase
H0S59_07650	COG0583	DNA-binding transcription factor activity
H0S59_07700	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_07740	COG2205	protein histidine kinase activity
H0S59_07740	COG0784	Response regulator, receiver
H0S59_07760	COG0765	amino acid transport
H0S59_07765	COG0765	amino acid transport
H0S59_07770	COG1126	abc transporter atp-binding protein
H0S59_07775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0S59_07780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0S59_07795	COG1280	lysine exporter protein (LysE YggA)
H0S59_07800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H0S59_07805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0S59_07810	COG1045	serine acetyltransferase
H0S59_07825	COG0583	DNA-binding transcription factor activity
H0S59_07830	COG0625	glutathione transferase activity
H0S59_07835	COG0625	glutathione transferase activity
H0S59_07840	COG0583	DNA-binding transcription factor activity
H0S59_07850	COG1346	cytolysis
H0S59_07855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S59_07870	COG2814	Major facilitator Superfamily
H0S59_07880	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H0S59_07885	COG3052	prosthetic group binding
H0S59_07905	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H0S59_07925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S59_07935	COG1294	oxidase, subunit
H0S59_07940	COG1271	oxidase subunit
H0S59_07960	COG0477	Major facilitator Superfamily
H0S59_07970	COG4521	taurine ABC transporter
H0S59_07975	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H0S59_07980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S59_07985	COG2175	clavaminate synthase activity
H0S59_07995	COG1953	Uracil, thiamine, allantoin
H0S59_08005	COG0583	DNA-binding transcription factor activity
H0S59_08015	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H0S59_08030	COG0640	Transcriptional regulator
H0S59_08035	COG0798	PFAM Bile acid sodium symporter
H0S59_08040	COG0583	DNA-binding transcription factor activity
H0S59_08055	COG3634	alkyl hydroperoxide reductase activity
H0S59_08090	COG1301	dicarboxylic acid transport
H0S59_08095	COG0436	Aminotransferase
H0S59_08105	COG0386	Belongs to the glutathione peroxidase family
H0S59_08115	COG1280	lysine exporter protein (LysE YggA)
H0S59_08145	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H0S59_08170	COG0012	GTP binding
H0S59_08175	COG2011	ABC-type metal ion transport system permease component
H0S59_08180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0S59_08185	COG1464	Belongs to the NlpA lipoprotein family
H0S59_08190	COG1464	Belongs to the NlpA lipoprotein family
H0S59_08220	COG0765	amino acid transport
H0S59_08225	COG0765	amino acid transport
H0S59_08230	COG1126	abc transporter atp-binding protein
H0S59_08240	COG1522	sequence-specific DNA binding
H0S59_08255	COG1309	transcriptional regulator
H0S59_08275	COG0583	DNA-binding transcription factor activity
H0S59_08285	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H0S59_08295	COG0697	spore germination
H0S59_08320	COG3121	Chaperone
H0S59_08325	COG3539	Fimbrial protein
H0S59_08350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0S59_08350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H0S59_08390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H0S59_08400	COG2353	YceI-like domain
H0S59_08410	COG3698	Phosphodiester glycosidase
H0S59_08425	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H0S59_08430	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H0S59_08430	COG0506	proline dehydrogenase activity
H0S59_08430	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H0S59_08440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S59_08445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H0S59_08465	COG1132	(ABC) transporter
H0S59_08470	COG3122	Protein conserved in bacteria
H0S59_08475	COG3619	membrane
H0S59_08485	COG0640	Transcriptional regulator
H0S59_08495	COG2850	peptidyl-arginine hydroxylation
H0S59_08500	COG0424	maF-like protein
H0S59_08520	COG0191	fructose-bisphosphate aldolase activity
H0S59_08525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S59_08540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H0S59_08550	COG1192	Involved in chromosome partitioning
H0S59_08555	COG1475	DNA binding
H0S59_08560	COG0811	peptide transport
H0S59_08570	COG1132	(ABC) transporter
H0S59_08575	COG1663	tetraacyldisaccharide 4'-kinase activity
H0S59_08595	COG0084	hydrolase, TatD family'
H0S59_08660	COG0776	regulation of translation
H0S59_08675	COG2431	L-lysine efflux transmembrane transporter activity
H0S59_08690	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H0S59_08695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H0S59_08720	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H0S59_08745	COG0339	signal peptide processing
H0S59_08750	COG0601	transmembrane transport
H0S59_08755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H0S59_08760	COG4172	Belongs to the ABC transporter superfamily
H0S59_08790	COG0702	epimerase
H0S59_08795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H0S59_08815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0S59_08845	COG0316	Belongs to the HesB IscA family
H0S59_08850	COG0822	iron-sulfur transferase activity
H0S59_08875	COG0776	regulation of translation
H0S59_08880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S59_08885	COG2207	Transcriptional regulator
H0S59_08890	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S59_08895	COG1960	acyl-CoA dehydrogenase activity
H0S59_08900	COG1960	acyl-CoA dehydrogenase activity
H0S59_08915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H0S59_08920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0S59_08935	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H0S59_08940	COG0406	alpha-ribazole phosphatase activity
H0S59_08955	COG4772	TonB-dependent receptor
H0S59_08965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0S59_08970	COG0730	response to heat
H0S59_08990	COG4773	Receptor
H0S59_08995	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S59_09010	COG1131	(ABC) transporter
H0S59_09015	COG0842	Transport permease protein
H0S59_09020	COG0842	Transport permease protein
H0S59_09075	COG2226	methyltransferase
H0S59_09100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H0S59_09135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S59_09145	COG0133	tryptophan synthase activity
H0S59_09175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0S59_09180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H0S59_09185	COG0022	dehydrogenase e1 component
H0S59_09190	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0S59_09195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S59_09205	COG1063	alcohol dehydrogenase
H0S59_09210	COG3781	membrane
H0S59_09220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S59_09220	COG3453	Protein conserved in bacteria
H0S59_09230	COG0730	response to heat
H0S59_09245	COG3708	Transcriptional regulator
H0S59_09245	COG2207	Transcriptional regulator
H0S59_09255	COG2188	Transcriptional regulator
H0S59_09270	COG4521	taurine ABC transporter
H0S59_09275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S59_09295	COG0477	Major facilitator Superfamily
H0S59_09305	COG1027	Aspartate ammonia-lyase
H0S59_09320	COG0583	DNA-binding transcription factor activity
H0S59_09325	COG0583	DNA-binding transcription factor activity
H0S59_09330	COG0183	Belongs to the thiolase family
H0S59_09335	COG2031	fatty acid transporter
H0S59_09350	COG0583	DNA-binding transcription factor activity
H0S59_09375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S59_09380	COG2610	gluconate transmembrane transporter activity
H0S59_09385	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_09390	COG2207	Transcriptional regulator
H0S59_09405	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_09415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S59_09430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S59_09430	COG0543	2 iron, 2 sulfur cluster binding
H0S59_09435	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H0S59_09440	COG4638	Rieske (2fe-2S)
H0S59_09450	COG0725	ABC transporter, periplasmic molybdate-binding protein
H0S59_09455	COG4149	molybdate abc transporter
H0S59_09460	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H0S59_09490	COG3251	PFAM MbtH domain protein
H0S59_09500	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_09505	COG1169	isochorismate synthase
H0S59_09510	COG1021	2,3-dihydroxybenzoate-AMP ligase
H0S59_09515	COG1535	isochorismatase
H0S59_09515	COG3433	isochorismatase activity
H0S59_09525	COG4771	TonB-dependent receptor
H0S59_09590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0S59_09605	COG0753	catalase activity
H0S59_09615	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H0S59_09640	COG3539	Fimbrial protein
H0S59_09650	COG1538	Outer membrane efflux protein
H0S59_09655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S59_09660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S59_09665	COG0745	RESPONSE REGULATOR receiver
H0S59_09670	COG2205	protein histidine kinase activity
H0S59_09675	COG3328	transposase activity
H0S59_09685	COG1309	transcriptional regulator
H0S59_09700	COG0583	DNA-binding transcription factor activity
H0S59_09705	COG1073	alpha beta
H0S59_09710	COG4221	oxidoreductase activity
H0S59_09715	COG1064	alcohol dehydrogenase
H0S59_09755	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H0S59_09820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0S59_09840	COG1120	ATPase activity
H0S59_09845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0S59_09855	COG2084	Dehydrogenase
H0S59_09865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0S59_09870	COG0583	DNA-binding transcription factor activity
H0S59_09880	COG0129	dihydroxy-acid dehydratase activity
H0S59_09885	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_09900	COG1566	PFAM secretion protein HlyD family protein
H0S59_09915	COG0583	DNA-binding transcription factor activity
H0S59_09920	COG2188	Transcriptional regulator
H0S59_09955	COG2831	hemolysin activation secretion protein
H0S59_09960	COG1309	transcriptional regulator
H0S59_09990	COG1309	transcriptional regulator
H0S59_10005	COG0789	Transcriptional regulator
H0S59_10015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H0S59_10040	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_10060	COG2186	Transcriptional regulator
H0S59_10070	COG0583	DNA-binding transcription factor activity
H0S59_10075	COG4948	Mandelate Racemase Muconate Lactonizing
H0S59_10080	COG4829	muconolactone delta-isomerase
H0S59_10090	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0S59_10095	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S59_10100	COG0183	Belongs to the thiolase family
H0S59_10105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S59_10110	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_10120	COG3733	amine oxidase
H0S59_10130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S59_10140	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_10150	COG4638	Rieske (2fe-2S)
H0S59_10170	COG0154	amidase activity
H0S59_10180	COG2814	Major facilitator Superfamily
H0S59_10205	COG1960	acyl-CoA dehydrogenase activity
H0S59_10210	COG0583	DNA-binding transcription factor activity
H0S59_10215	COG1414	Transcriptional regulator
H0S59_10230	COG2391	methyltransferase activity
H0S59_10240	COG4993	Dehydrogenase
H0S59_10245	COG3659	wide pore channel activity
H0S59_10250	COG3420	alginic acid biosynthetic process
H0S59_10255	COG0710	3-dehydroquinate dehydratase activity
H0S59_10260	COG3485	protocatechuate 3,4-dioxygenase
H0S59_10265	COG3485	protocatechuate 3,4-dioxygenase
H0S59_10270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H0S59_10275	COG2271	Major facilitator Superfamily
H0S59_10280	COG0596	Alpha beta hydrolase
H0S59_10285	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H0S59_10290	COG0183	Belongs to the thiolase family
H0S59_10295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S59_10300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0S59_10310	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H0S59_10320	COG2323	membrane
H0S59_10360	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S59_10360	COG1902	pentaerythritol trinitrate reductase activity
H0S59_10385	COG0542	response to heat
H0S59_10390	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H0S59_10420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0S59_10425	COG0569	domain protein
H0S59_10430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0S59_10445	COG4774	siderophore transport
H0S59_10450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0S59_10460	COG1585	Membrane protein implicated in regulation of membrane protease activity
H0S59_10475	COG1294	oxidase, subunit
H0S59_10480	COG4890	Cyd operon protein YbgT
H0S59_10495	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H0S59_10505	COG0552	protein localization to endoplasmic reticulum
H0S59_10530	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0S59_10530	COG0517	IMP dehydrogenase activity
H0S59_10535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0S59_10540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H0S59_10550	COG0583	DNA-binding transcription factor activity
H0S59_10555	COG0024	Methionine aminopeptidase
H0S59_10585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H0S59_10585	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0S59_10590	COG1105	Belongs to the carbohydrate kinase PfkB family
H0S59_10595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0S59_10595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0S59_10595	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H0S59_10610	COG3300	MHYT domain
H0S59_10610	COG5001	Diguanylate cyclase
H0S59_10625	COG2135	peptidase activity
H0S59_10635	COG3328	transposase activity
H0S59_10650	COG4372	Transposase
H0S59_10670	COG1113	amino acid transport
H0S59_10680	COG1522	sequence-specific DNA binding
H0S59_10700	COG1011	Hydrolase
H0S59_10705	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H0S59_10715	COG2137	regulation of response to DNA damage stimulus
H0S59_10730	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S59_10765	COG0575	Belongs to the CDS family
H0S59_10770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0S59_10795	COG3852	Histidine kinase
H0S59_10800	COG2204	response regulator
H0S59_10855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S59_10860	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H0S59_10880	COG0697	spore germination
H0S59_10885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S59_10895	COG0303	'Molybdopterin
H0S59_10900	COG0521	Mo-molybdopterin cofactor biosynthetic process
H0S59_10900	COG0315	cyclic pyranopterin monophosphate synthase activity
H0S59_10915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H0S59_10920	COG0243	molybdopterin cofactor binding
H0S59_10930	COG0243	molybdopterin cofactor binding
H0S59_10935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S59_10940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S59_10940	COG2146	nitrite reductase [NAD(P)H] activity
H0S59_10950	COG0745	RESPONSE REGULATOR receiver
H0S59_10955	COG1116	anion transmembrane transporter activity
H0S59_10955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S59_10975	COG0511	ligase activity, forming carbon-carbon bonds
H0S59_10980	COG0439	Biotin carboxylase
H0S59_10990	COG2814	Major facilitator Superfamily
H0S59_11025	COG3293	Transposase
H0S59_11030	COG1063	alcohol dehydrogenase
H0S59_11110	COG0592	DNA-directed DNA polymerase activity
H0S59_11160	COG2026	Addiction module toxin, RelE StbE family
H0S59_11365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0S59_11425	COG3328	transposase activity
H0S59_11450	COG0069	glutamate synthase activity
H0S59_11480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0S59_11495	COG1335	isochorismatase
H0S59_11505	COG1454	alcohol dehydrogenase
H0S59_11510	COG0824	Thioesterase
H0S59_11525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0S59_11550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H0S59_11555	COG2030	dehydratase
H0S59_11565	COG0183	Belongs to the thiolase family
H0S59_11575	COG0583	DNA-binding transcription factor activity
H0S59_11580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0S59_11590	COG1522	sequence-specific DNA binding
H0S59_11595	COG3135	benzoate transporter
H0S59_11620	COG0589	response to stress
H0S59_11625	COG0488	(ABC) transporter
H0S59_11670	COG0668	transmembrane transport
H0S59_11675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0S59_11680	COG2423	ornithine cyclodeaminase activity
H0S59_11685	COG4264	IucA IucC family
H0S59_11695	COG4264	IucA IucC family
H0S59_11735	COG1605	Chorismate mutase
H0S59_11775	COG0308	aminopeptidase N
H0S59_11795	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H0S59_11805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S59_11810	COG1454	alcohol dehydrogenase
H0S59_11830	COG0531	amino acid
H0S59_11835	COG4303	Ethanolamine ammonia lyase large subunit
H0S59_11840	COG4302	ethanolamine ammonia-lyase activity
H0S59_11845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0S59_11845	COG0519	Catalyzes the synthesis of GMP from XMP
H0S59_11870	COG0697	spore germination
H0S59_11875	COG1923	regulation of RNA biosynthetic process
H0S59_11885	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H0S59_11890	COG0802	atpase or kinase
H0S59_11910	COG1187	pseudouridine synthase activity
H0S59_11925	COG0583	DNA-binding transcription factor activity
H0S59_11935	COG2814	Major facilitator Superfamily
H0S59_11940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0S59_11970	COG0729	surface antigen
H0S59_11990	COG0174	glutamine synthetase
H0S59_11995	COG0745	RESPONSE REGULATOR receiver
H0S59_12000	COG2205	protein histidine kinase activity
H0S59_12005	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H0S59_12010	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H0S59_12015	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H0S59_12040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S59_12045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S59_12050	COG1960	acyl-CoA dehydrogenase activity
H0S59_12065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S59_12070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S59_12075	COG2890	protein-(glutamine-N5) methyltransferase activity
H0S59_12090	COG0583	DNA-binding transcription factor activity
H0S59_12105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S59_12115	COG3658	cytochrome
H0S59_12120	COG1215	transferase activity, transferring glycosyl groups
H0S59_12125	COG0726	polysaccharide deacetylase
H0S59_12125	COG1649	PFAM Uncharacterised BCR, COG1649
H0S59_12155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H0S59_12165	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H0S59_12190	COG0305	Participates in initiation and elongation during chromosome replication
H0S59_12195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0S59_12205	COG1305	Transglutaminase-like
H0S59_12215	COG2308	Evidence 4 Homologs of previously reported genes of
H0S59_12250	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H0S59_12255	COG0138	bifunctional purine biosynthesis protein purh
H0S59_12260	COG0151	Belongs to the GarS family
H0S59_12265	COG1464	Belongs to the NlpA lipoprotein family
H0S59_12270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0S59_12275	COG2011	ABC-type metal ion transport system permease component
H0S59_12280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S59_12290	COG1301	dicarboxylic acid transport
H0S59_12330	COG0745	RESPONSE REGULATOR receiver
H0S59_12335	COG0642	Histidine kinase
H0S59_12340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H0S59_12350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H0S59_12375	COG5002	protein histidine kinase activity
H0S59_12390	COG2351	hydroxyisourate hydrolase activity
H0S59_12400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H0S59_12400	COG3008	intermembrane lipid transfer
H0S59_12405	COG2995	paraquat-inducible protein a
H0S59_12425	COG2207	Transcriptional regulator
H0S59_12430	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_12435	COG0583	DNA-binding transcription factor activity
H0S59_12445	COG3328	transposase activity
H0S59_12450	COG1073	alpha beta
H0S59_12515	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_12520	COG0475	glutathione-regulated potassium exporter activity
H0S59_12520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0S59_12525	COG0786	glutamate:sodium symporter activity
H0S59_12530	COG3243	poly(R)-hydroxyalkanoic acid synthase
H0S59_12545	COG3111	PFAM Bacterial OB fold (BOF) protein
H0S59_12555	COG2226	methyltransferase
H0S59_12635	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
H0S59_12670	COG3210	domain, Protein
H0S59_12670	COG3210	domain, Protein
H0S59_12675	COG2831	hemolysin activation secretion protein
H0S59_12700	COG0515	serine threonine protein kinase
H0S59_12700	COG2815	serine threonine protein kinase
H0S59_12730	COG1610	YqeY-like protein
H0S59_12760	COG1286	toxin biosynthetic process
H0S59_12790	COG0778	Nitroreductase
H0S59_12800	COG0513	Belongs to the DEAD box helicase family
H0S59_12820	COG2363	Small membrane protein
H0S59_12845	COG1234	tRNA 3'-trailer cleavage
H0S59_12850	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0S59_12855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0S59_12865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H0S59_12885	COG1960	acyl-CoA dehydrogenase activity
H0S59_12890	COG1301	dicarboxylic acid transport
H0S59_12895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0S59_12900	COG3139	Protein of unknown function (DUF1315)
H0S59_12905	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0S59_12910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0S59_12920	COG0494	nUDIX hydrolase
H0S59_12930	COG0642	Histidine kinase
H0S59_12940	COG3111	PFAM Bacterial OB fold (BOF) protein
H0S59_12945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H0S59_12955	COG1720	tRNA m6t6A37 methyltransferase activity
H0S59_12965	COG0384	phenazine biosynthesis protein PhzF
H0S59_12970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S59_12975	COG0826	peptidase U32
H0S59_12980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S59_12990	COG4598	ABC transporter
H0S59_12995	COG4160	amino acid transport
H0S59_13000	COG4215	(ABC) transporter
H0S59_13015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S59_13055	COG1131	(ABC) transporter
H0S59_13060	COG0842	Transport permease protein
H0S59_13075	COG0772	Belongs to the SEDS family
H0S59_13080	COG2951	lytic endotransglycosylase activity
H0S59_13105	COG2207	Transcriptional regulator
H0S59_13120	COG0052	Belongs to the universal ribosomal protein uS2 family
H0S59_13125	COG0024	Methionine aminopeptidase
H0S59_13135	COG2223	nitrite transmembrane transporter activity
H0S59_13145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S59_13150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0S59_13155	COG1960	acyl-CoA dehydrogenase activity
H0S59_13170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H0S59_13175	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H0S59_13180	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0S59_13200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S59_13205	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0S59_13210	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0S59_13245	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H0S59_13255	COG0174	glutamine synthetase
H0S59_13270	COG0512	Glutamine amidotransferase of anthranilate synthase
H0S59_13295	COG2840	Smr protein MutS2
H0S59_13315	COG0302	gtp cyclohydrolase
H0S59_13335	COG3739	integral membrane protein
H0S59_13350	COG1741	Belongs to the pirin family
H0S59_13355	COG2964	Protein conserved in bacteria
H0S59_13400	COG2879	small protein
H0S59_13405	COG1966	Carbon starvation protein
H0S59_13410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H0S59_13425	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H0S59_13450	COG1067	ATP-dependent peptidase activity
H0S59_13455	COG0583	DNA-binding transcription factor activity
H0S59_13480	COG1686	Belongs to the peptidase S11 family
H0S59_13485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0S59_13510	COG3647	Membrane
H0S59_13525	COG0616	signal peptide processing
H0S59_13530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0S59_13540	COG0573	inorganic phosphate transmembrane transporter activity
H0S59_13545	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H0S59_13550	COG1113	amino acid transport
H0S59_13555	COG3961	Belongs to the TPP enzyme family
H0S59_13560	COG1522	sequence-specific DNA binding
H0S59_13570	COG0076	glutamate decarboxylase activity
H0S59_13575	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H0S59_13600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S59_13635	COG0352	thiamine-phosphate diphosphorylase activity
H0S59_13660	COG0612	Peptidase, M16
H0S59_13670	COG1823	symporter activity
H0S59_13675	COG0583	DNA-binding transcription factor activity
H0S59_13680	COG0477	Major facilitator Superfamily
H0S59_13705	COG1187	pseudouridine synthase activity
H0S59_13720	COG1686	Belongs to the peptidase S11 family
H0S59_13725	COG1252	NADH dehydrogenase
H0S59_13735	COG0415	Belongs to the DNA photolyase family
H0S59_13750	COG1215	transferase activity, transferring glycosyl groups
H0S59_13780	COG2070	2-Nitropropane dioxygenase
H0S59_13835	COG0556	nucleotide-excision repair
H0S59_13855	COG0436	Aminotransferase
H0S59_13885	COG4221	oxidoreductase activity
H0S59_13895	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H0S59_13900	COG1381	Involved in DNA repair and RecF pathway recombination
H0S59_13910	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0S59_13925	COG0681	Belongs to the peptidase S26 family
H0S59_13930	COG0481	GTPase activity
H0S59_13945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S59_13965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H0S59_13970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H0S59_13975	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0S59_13985	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H0S59_13990	COG4208	sulfate ABC transporter
H0S59_13995	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H0S59_14000	COG0583	DNA-binding transcription factor activity
H0S59_14005	COG4625	pathogenesis
H0S59_14015	COG0602	queuosine metabolic process
H0S59_14020	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H0S59_14035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0S59_14050	COG1056	cytidyltransferase-related domain
H0S59_14050	COG1051	belongs to the nudix hydrolase family
H0S59_14055	COG1024	Enoyl-CoA hydratase
H0S59_14060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0S59_14075	COG2814	Major facilitator Superfamily
H0S59_14080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0S59_14080	COG0047	phosphoribosylformylglycinamidine synthase activity
H0S59_14105	COG1473	amidohydrolase
H0S59_14110	COG0824	Thioesterase
H0S59_14130	COG0823	Involved in the tonB-independent uptake of proteins
H0S59_14150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S59_14185	COG0628	permease
H0S59_14195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H0S59_14200	COG0596	Alpha beta hydrolase
H0S59_14205	COG0616	signal peptide processing
H0S59_14205	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H0S59_14220	COG1136	(ABC) transporter
H0S59_14225	COG4591	ABC-type transport system involved in lipoprotein release permease component
H0S59_14260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S59_14280	COG0463	Glycosyl transferase, family 2
H0S59_14290	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H0S59_14300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S59_14320	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H0S59_14325	COG1280	lysine exporter protein (LysE YggA)
H0S59_14340	COG0019	diaminopimelate decarboxylase activity
H0S59_14350	COG1113	amino acid transport
H0S59_14355	COG1113	amino acid transport
H0S59_14370	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H0S59_14380	COG3339	Conserved Protein
H0S59_14385	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H0S59_14390	COG0243	molybdopterin cofactor binding
H0S59_14395	COG1929	Belongs to the glycerate kinase type-1 family
H0S59_14405	COG0300	oxidoreductase activity
H0S59_14410	COG0778	Nitroreductase
H0S59_14415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S59_14420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S59_14430	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_14435	COG0596	Alpha beta hydrolase
H0S59_14440	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0S59_14440	COG0596	Alpha beta hydrolase
H0S59_14445	COG1902	pentaerythritol trinitrate reductase activity
H0S59_14450	COG1309	transcriptional regulator
H0S59_14480	COG3811	Belongs to the UPF0386 family
H0S59_14490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0S59_14515	COG2059	Chromate
H0S59_14525	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H0S59_14535	COG1230	cation diffusion facilitator family transporter
H0S59_14550	COG2814	Major facilitator Superfamily
H0S59_14660	COG0582	viral genome integration into host DNA
H0S59_14670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0S59_14690	COG0741	lytic transglycosylase activity
H0S59_14710	COG0584	glycerophosphoryl diester phosphodiesterase
H0S59_14715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S59_14735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0S59_14740	COG1597	lipid kinase activity
H0S59_14755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0S59_14760	COG0477	Major facilitator Superfamily
H0S59_14810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0S59_14815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S59_14840	COG0505	Belongs to the CarA family
H0S59_14855	COG1309	transcriptional regulator
H0S59_14860	COG0251	oxidation-reduction process
H0S59_14865	COG0110	maltose O-acetyltransferase activity
H0S59_14870	COG0589	response to stress
H0S59_14890	COG2843	Capsule synthesis protein
H0S59_14910	COG2321	neutral zinc metallopeptidase
H0S59_14915	COG2354	Protein conserved in bacteria
H0S59_14935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S59_14960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0S59_14965	COG1053	succinate dehydrogenase
H0S59_14970	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H0S59_14975	COG2009	succinate dehydrogenase
H0S59_15010	COG2921	Belongs to the UPF0250 family
H0S59_15015	COG0321	lipoyl(octanoyl) transferase activity
H0S59_15030	COG0531	amino acid
H0S59_15040	COG1733	regulation of RNA biosynthetic process
H0S59_15045	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H0S59_15050	COG1648	precorrin-2 dehydrogenase activity
H0S59_15050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H0S59_15065	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H0S59_15095	COG0671	phosphoesterase, PA-phosphatase related
H0S59_15100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S59_15110	COG1538	Outer membrane efflux protein
H0S59_15115	COG0393	Putative heavy-metal-binding
H0S59_15120	COG0393	Putative heavy-metal-binding
H0S59_15130	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_15140	COG0525	valine-tRNA ligase activity
H0S59_15160	COG0583	DNA-binding transcription factor activity
H0S59_15165	COG0004	ammonium transporteR
H0S59_15175	COG0642	Histidine kinase
H0S59_15180	COG0745	RESPONSE REGULATOR receiver
H0S59_15185	COG2194	sulfuric ester hydrolase activity
H0S59_15205	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S59_15220	COG2315	Protein conserved in bacteria
H0S59_15225	COG0142	geranyltranstransferase activity
H0S59_15235	COG1113	amino acid transport
H0S59_15240	COG2816	NAD+ diphosphatase activity
H0S59_15245	COG3046	protein related to deoxyribodipyrimidine photolyase
H0S59_15275	COG2207	Transcriptional regulator
H0S59_15300	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0S59_15320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0S59_15330	COG1530	ribonuclease E activity
H0S59_15335	COG0424	maF-like protein
H0S59_15340	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H0S59_15345	COG1792	Involved in formation and maintenance of cell shape
H0S59_15350	COG1077	Cell shape determining protein MreB Mrl
H0S59_15355	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S59_15365	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S59_15390	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H0S59_15395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0S59_15400	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S59_15405	COG1115	amino acid carrier protein
H0S59_15425	COG2814	Major facilitator Superfamily
H0S59_15430	COG1289	transmembrane transporter activity
H0S59_15440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H0S59_15455	COG1376	ErfK ybiS ycfS ynhG family protein
H0S59_15460	COG2832	Protein of unknown function (DUF454)
H0S59_15490	COG0840	transmembrane signaling receptor activity
H0S59_15530	COG3422	double-strand break repair
H0S59_15535	COG2824	Alkylphosphonate utilization operon protein PhnA
H0S59_15540	COG3189	MarR family transcriptional regulator
H0S59_15550	COG0354	folic acid binding
H0S59_15555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S59_15565	COG0679	Auxin Efflux Carrier
H0S59_15570	COG1902	pentaerythritol trinitrate reductase activity
H0S59_15575	COG4772	TonB-dependent receptor
H0S59_15580	COG2094	Belongs to the DNA glycosylase MPG family
H0S59_15600	COG1217	gtp-binding protein TYPA
H0S59_15605	COG2233	PERMEase
H0S59_15615	COG0833	amino acid
H0S59_15620	COG1690	Belongs to the RtcB family
H0S59_15630	COG2885	chlorophyll binding
H0S59_15630	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H0S59_15640	COG0183	Belongs to the thiolase family
H0S59_15660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S59_15680	COG2207	Transcriptional regulator
H0S59_15685	COG0183	Belongs to the thiolase family
H0S59_15715	COG1272	protein, Hemolysin III
H0S59_15720	COG0477	Major facilitator Superfamily
H0S59_15735	COG0450	alkyl hydroperoxide reductase
H0S59_15755	COG0285	dihydrofolate synthase activity
H0S59_15810	COG2096	Adenosyltransferase
H0S59_15830	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H0S59_15835	COG0745	RESPONSE REGULATOR receiver
H0S59_15840	COG2205	protein histidine kinase activity
H0S59_15850	COG1960	acyl-CoA dehydrogenase activity
H0S59_15855	COG1960	acyl-CoA dehydrogenase activity
H0S59_15920	COG0438	transferase activity, transferring glycosyl groups
H0S59_15925	COG0463	Glycosyl transferase, family 2
H0S59_15930	COG0726	polysaccharide deacetylase
H0S59_15940	COG2194	sulfuric ester hydrolase activity
H0S59_15955	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H0S59_15960	COG0784	Response regulator, receiver
H0S59_15960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0S59_15960	COG2198	Histidine kinase
H0S59_15960	COG2205	protein histidine kinase activity
H0S59_15965	COG4695	Portal protein
H0S59_16160	COG0629	single-stranded DNA binding
H0S59_16210	COG1862	Preprotein translocase
H0S59_16220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0S59_16225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H0S59_16235	COG3781	membrane
H0S59_16240	COG0613	PHP domain protein
H0S59_16250	COG2350	Protein conserved in bacteria
H0S59_16285	COG1607	acyl-coa hydrolase
H0S59_16345	COG2199	diguanylate cyclase activity
H0S59_16355	COG1408	metallophosphoesterase
H0S59_16360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0S59_16370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0S59_16390	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H0S59_16395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0S59_16400	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H0S59_16405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0S59_16410	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0S59_16420	COG2969	positive regulation of protein catabolic process
H0S59_16460	COG1960	acyl-CoA dehydrogenase activity
H0S59_16465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0S59_16480	COG1309	transcriptional regulator
H0S59_16485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0S59_16490	COG1960	acyl-CoA dehydrogenase activity
H0S59_16540	COG1183	phosphatidylcholine synthase activity
H0S59_16545	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H0S59_16575	COG0741	lytic transglycosylase activity
H0S59_16575	COG1196	nuclear chromosome segregation
H0S59_16575	COG0739	heme binding
H0S59_16585	COG1702	phosphate starvation-inducible protein PhoH
H0S59_16620	COG1295	ribonuclease BN
H0S59_16630	COG2169	Transcriptional regulator
H0S59_16635	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0S59_16680	COG0557	exoribonuclease II activity
H0S59_16685	COG0339	signal peptide processing
H0S59_16690	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H0S59_16720	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H0S59_16725	COG1960	acyl-CoA dehydrogenase activity
H0S59_16860	COG0088	Forms part of the polypeptide exit tunnel
H0S59_16865	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H0S59_16880	COG0626	cystathionine gamma-synthase activity
H0S59_16885	COG0433	COG0433 Predicted ATPase
H0S59_16890	COG1017	nitric oxide dioxygenase activity
H0S59_16890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S59_16895	COG1959	2 iron, 2 sulfur cluster binding
H0S59_16910	COG1301	dicarboxylic acid transport
H0S59_16915	COG1946	Acyl-CoA thioesterase
H0S59_16935	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0S59_16940	COG1040	competence protein
H0S59_16945	COG0494	nUDIX hydrolase
H0S59_16955	COG0598	Magnesium transport protein CorA
H0S59_16965	COG2854	intermembrane phospholipid transfer
H0S59_16975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0S59_16980	COG1127	ABC transporter
H0S59_17005	COG0408	coproporphyrinogen oxidase activity
H0S59_17020	COG1960	acyl-CoA dehydrogenase activity
H0S59_17030	COG1983	PspC domain protein
H0S59_17035	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H0S59_17035	COG0617	tRNA 3'-terminal CCA addition
H0S59_17035	COG0517	IMP dehydrogenase activity
H0S59_17080	COG0583	DNA-binding transcription factor activity
H0S59_17120	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_17130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0S59_17135	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0S59_17140	COG0833	amino acid
H0S59_17170	COG1192	Involved in chromosome partitioning
H0S59_17175	COG0628	permease
H0S59_17185	COG1289	transmembrane transporter activity
H0S59_17200	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0S59_17205	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H0S59_17220	COG0277	FAD linked oxidase domain protein
H0S59_17225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0S59_17230	COG5006	permease, DMT superfamily
H0S59_17235	COG5006	permease, DMT superfamily
H0S59_17250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H0S59_17255	COG5380	lipid catabolic process
H0S59_17275	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0S59_17325	COG0194	GDP metabolic process
H0S59_17340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0S59_17360	COG3307	-O-antigen
H0S59_17370	COG3307	-O-antigen
H0S59_17375	COG4969	Belongs to the N-Me-Phe pilin family
H0S59_17385	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H0S59_17390	COG1704	LemA family
H0S59_17400	COG0493	'glutamate synthase
H0S59_17405	COG0067	glutamate synthase
H0S59_17405	COG0069	glutamate synthase activity
H0S59_17405	COG0070	glutamate synthase
H0S59_17455	COG2226	methyltransferase
H0S59_17470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0S59_17475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0S59_17520	COG0833	amino acid
H0S59_17585	COG0488	(ABC) transporter
H0S59_17590	COG0028	Belongs to the TPP enzyme family
H0S59_17595	COG2873	o-acetylhomoserine
H0S59_17600	COG4221	oxidoreductase activity
H0S59_17605	COG0659	secondary active sulfate transmembrane transporter activity
H0S59_17630	COG0427	acetyl-CoA hydrolase
H0S59_17660	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0S59_17680	COG1132	(ABC) transporter
H0S59_17705	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H0S59_17770	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0S59_17775	COG1733	regulation of RNA biosynthetic process
H0S59_17800	COG0667	Aldo Keto reductase
H0S59_17820	COG0583	DNA-binding transcription factor activity
H0S59_17825	COG2814	Major facilitator Superfamily
H0S59_17860	COG1335	isochorismatase
H0S59_17870	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_17875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H0S59_17885	COG1113	amino acid transport
H0S59_17895	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H0S59_17910	COG2814	Major facilitator Superfamily
H0S59_17920	COG0352	thiamine-phosphate diphosphorylase activity
H0S59_17920	COG0351	phosphomethylpyrimidine kinase
H0S59_17920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0S59_17940	COG1309	transcriptional regulator
H0S59_17960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S59_17970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S59_17975	COG3162	membrane
H0S59_17980	COG2198	Histidine kinase
H0S59_17980	COG0784	Response regulator, receiver
H0S59_17980	COG2205	protein histidine kinase activity
H0S59_18005	COG1522	sequence-specific DNA binding
H0S59_18010	COG1335	isochorismatase
H0S59_18015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S59_18025	COG0668	transmembrane transport
H0S59_18030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0S59_18035	COG1519	Transferase
H0S59_18040	COG1902	pentaerythritol trinitrate reductase activity
H0S59_18060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H0S59_18085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S59_18085	COG0426	domain, Protein
H0S59_18090	COG2119	membrane
H0S59_18100	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0S59_18110	COG4942	peptidase
H0S59_18125	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0S59_18135	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H0S59_18155	COG0189	ligase activity
H0S59_18175	COG0708	Exodeoxyribonuclease III
H0S59_18180	COG1393	Belongs to the ArsC family
H0S59_18195	COG3706	GGDEF domain
H0S59_18230	COG2351	hydroxyisourate hydrolase activity
H0S59_18235	COG2233	PERMEase
H0S59_18245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S59_18255	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H0S59_18265	COG3150	esterase
H0S59_18310	COG2918	glutathione biosynthetic process
H0S59_18325	COG2733	membrane
H0S59_18330	COG0436	Aminotransferase
H0S59_18335	COG0534	Mate efflux family protein
H0S59_18425	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0S59_18430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H0S59_18440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0S59_18455	COG1280	lysine exporter protein (LysE YggA)
H0S59_18460	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0S59_18475	COG0010	Belongs to the arginase family
H0S59_18505	COG2188	Transcriptional regulator
H0S59_18515	COG0523	cobalamin synthesis protein
H0S59_18525	COG1113	amino acid transport
H0S59_18535	COG0625	glutathione transferase activity
H0S59_18560	COG0534	Mate efflux family protein
H0S59_18565	COG0385	Bile acid
H0S59_18570	COG1335	isochorismatase
H0S59_18575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S59_18595	COG2116	formate transmembrane transporter activity
H0S59_18605	COG2814	Major facilitator Superfamily
H0S59_18640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S59_18655	COG2233	PERMEase
H0S59_18695	COG0733	neurotransmitter:sodium symporter activity
H0S59_18705	COG0625	glutathione transferase activity
H0S59_18735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0S59_18740	COG0657	acetylesterase activity
H0S59_18790	COG2951	lytic endotransglycosylase activity
H0S59_18795	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H0S59_18810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0S59_18820	COG0671	phosphoesterase, PA-phosphatase related
H0S59_18825	COG0861	Integral membrane protein TerC family
H0S59_18840	COG0754	glutathionylspermidine amidase activity
H0S59_18850	COG0402	S-adenosylhomocysteine deaminase activity
H0S59_18865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S59_18870	COG1230	cation diffusion facilitator family transporter
H0S59_18885	COG0706	membrane insertase activity