locus-tag	class	description
AOLE_00010	COG0592	DNA-directed DNA polymerase activity
AOLE_00020	COG0187	DNA topoisomerase II activity
AOLE_00035	COG0488	(ABC) transporter
AOLE_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AOLE_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AOLE_00075	COG0625	glutathione transferase activity
AOLE_00085	COG0733	neurotransmitter:sodium symporter activity
AOLE_00125	COG2233	PERMEase
AOLE_00140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOLE_00175	COG2814	Major facilitator Superfamily
AOLE_00180	COG0656	L-ascorbic acid biosynthetic process
AOLE_00185	COG0583	DNA-binding transcription factor activity
AOLE_00200	COG1064	alcohol dehydrogenase
AOLE_00205	COG2818	Glycosylase
AOLE_00220	COG1194	a g-specific adenine glycosylase
AOLE_00235	COG5487	UPF0391 membrane protein
AOLE_00240	COG2983	Belongs to the UPF0260 family
AOLE_00245	COG2133	pyrroloquinoline quinone binding
AOLE_00250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AOLE_00255	COG2116	formate transmembrane transporter activity
AOLE_00275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOLE_00280	COG1335	isochorismatase
AOLE_00285	COG0385	Bile acid
AOLE_00290	COG0534	Mate efflux family protein
AOLE_00295	COG1683	Conserved Protein
AOLE_00310	COG0346	lactoylglutathione lyase activity
AOLE_00315	COG0625	glutathione transferase activity
AOLE_00325	COG1113	amino acid transport
AOLE_00335	COG0523	cobalamin synthesis protein
AOLE_00345	COG2188	Transcriptional regulator
AOLE_00375	COG0010	Belongs to the arginase family
AOLE_00385	COG0546	phosphoglycolate phosphatase activity
AOLE_00390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AOLE_00410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AOLE_00420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AOLE_00425	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AOLE_00530	COG0534	Mate efflux family protein
AOLE_00535	COG0436	Aminotransferase
AOLE_00540	COG2733	membrane
AOLE_00555	COG2918	glutathione biosynthetic process
AOLE_00565	COG3501	Rhs element vgr protein
AOLE_00590	COG3150	esterase
AOLE_00600	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AOLE_00610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOLE_00620	COG2233	PERMEase
AOLE_00625	COG2351	hydroxyisourate hydrolase activity
AOLE_00660	COG3706	GGDEF domain
AOLE_00675	COG1393	Belongs to the ArsC family
AOLE_00680	COG0708	Exodeoxyribonuclease III
AOLE_00700	COG0189	ligase activity
AOLE_00720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AOLE_00730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AOLE_00745	COG4942	peptidase
AOLE_00755	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOLE_00765	COG2119	membrane
AOLE_00770	COG4774	siderophore transport
AOLE_00775	COG0426	domain, Protein
AOLE_00775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOLE_00795	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AOLE_00815	COG1902	pentaerythritol trinitrate reductase activity
AOLE_00820	COG1519	Transferase
AOLE_00825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AOLE_00830	COG0668	transmembrane transport
AOLE_00840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOLE_00845	COG1335	isochorismatase
AOLE_00850	COG1522	sequence-specific DNA binding
AOLE_00875	COG0784	Response regulator, receiver
AOLE_00875	COG2198	Histidine kinase
AOLE_00875	COG2205	protein histidine kinase activity
AOLE_00880	COG3162	membrane
AOLE_00885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOLE_00895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOLE_00905	COG3706	GGDEF domain
AOLE_00915	COG1309	transcriptional regulator
AOLE_00935	COG4221	oxidoreductase activity
AOLE_00945	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AOLE_00945	COG0351	phosphomethylpyrimidine kinase
AOLE_00945	COG0352	thiamine-phosphate diphosphorylase activity
AOLE_00955	COG2814	Major facilitator Superfamily
AOLE_00960	COG0629	single-stranded DNA binding
AOLE_00970	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AOLE_00980	COG1113	amino acid transport
AOLE_00990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AOLE_00995	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_01005	COG1335	isochorismatase
AOLE_01040	COG2814	Major facilitator Superfamily
AOLE_01045	COG0583	DNA-binding transcription factor activity
AOLE_01070	COG1309	transcriptional regulator
AOLE_01110	COG0667	Aldo Keto reductase
AOLE_01150	COG1733	regulation of RNA biosynthetic process
AOLE_01155	COG2249	NAD(P)H dehydrogenase (quinone) activity
AOLE_01165	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AOLE_01170	COG2207	Transcriptional regulator
AOLE_01220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AOLE_01235	COG2329	Antibiotic biosynthesis monooxygenase
AOLE_01240	COG0697	spore germination
AOLE_01255	COG4619	ABC transporter
AOLE_01275	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AOLE_01295	COG0427	acetyl-CoA hydrolase
AOLE_01300	COG2205	protein histidine kinase activity
AOLE_01305	COG0745	RESPONSE REGULATOR receiver
AOLE_01315	COG0659	secondary active sulfate transmembrane transporter activity
AOLE_01320	COG4221	oxidoreductase activity
AOLE_01330	COG2814	Major facilitator Superfamily
AOLE_01345	COG0488	(ABC) transporter
AOLE_01400	COG0833	amino acid
AOLE_01445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AOLE_01450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AOLE_01465	COG2226	methyltransferase
AOLE_01515	COG0070	glutamate synthase
AOLE_01515	COG0069	glutamate synthase activity
AOLE_01515	COG0067	glutamate synthase
AOLE_01520	COG0493	'glutamate synthase
AOLE_01530	COG1704	LemA family
AOLE_01535	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AOLE_01545	COG4969	Belongs to the N-Me-Phe pilin family
AOLE_01555	COG3307	-O-antigen
AOLE_01575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOLE_01590	COG0194	GDP metabolic process
AOLE_01640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AOLE_01650	COG0335	large ribosomal subunit rRNA binding
AOLE_01660	COG5380	lipid catabolic process
AOLE_01665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AOLE_01680	COG5006	permease, DMT superfamily
AOLE_01685	COG5006	permease, DMT superfamily
AOLE_01695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AOLE_01700	COG0277	FAD linked oxidase domain protein
AOLE_01720	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AOLE_01725	COG2249	NAD(P)H dehydrogenase (quinone) activity
AOLE_01745	COG1289	transmembrane transporter activity
AOLE_01755	COG0628	permease
AOLE_01760	COG1192	Involved in chromosome partitioning
AOLE_01790	COG0833	amino acid
AOLE_01795	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AOLE_01800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOLE_01810	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_01850	COG0583	DNA-binding transcription factor activity
AOLE_01880	COG0752	glycyl-tRNA synthetase alpha subunit
AOLE_01915	COG4109	DRTGG domain
AOLE_01920	COG1983	PspC domain protein
AOLE_01930	COG1960	acyl-CoA dehydrogenase activity
AOLE_01945	COG0408	coproporphyrinogen oxidase activity
AOLE_01965	COG0513	Belongs to the DEAD box helicase family
AOLE_01970	COG1127	ABC transporter
AOLE_01975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AOLE_01985	COG2854	intermembrane phospholipid transfer
AOLE_01995	COG0598	Magnesium transport protein CorA
AOLE_02005	COG0494	nUDIX hydrolase
AOLE_02010	COG1040	competence protein
AOLE_02015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AOLE_02040	COG1946	Acyl-CoA thioesterase
AOLE_02045	COG1301	dicarboxylic acid transport
AOLE_02060	COG1959	2 iron, 2 sulfur cluster binding
AOLE_02065	COG1017	nitric oxide dioxygenase activity
AOLE_02065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOLE_02070	COG0433	COG0433 Predicted ATPase
AOLE_02075	COG0626	cystathionine gamma-synthase activity
AOLE_02090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AOLE_02095	COG0088	Forms part of the polypeptide exit tunnel
AOLE_02115	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AOLE_02195	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AOLE_02205	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AOLE_02230	COG1960	acyl-CoA dehydrogenase activity
AOLE_02235	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AOLE_02270	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AOLE_02275	COG0339	signal peptide processing
AOLE_02280	COG0557	exoribonuclease II activity
AOLE_02305	COG0179	Fumarylacetoacetate (FAA) hydrolase
AOLE_02310	COG1295	ribonuclease BN
AOLE_02345	COG1702	phosphate starvation-inducible protein PhoH
AOLE_02355	COG0741	lytic transglycosylase activity
AOLE_02355	COG1196	nuclear chromosome segregation
AOLE_02355	COG0739	heme binding
AOLE_02385	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AOLE_02390	COG1183	phosphatidylcholine synthase activity
AOLE_02410	COG1960	acyl-CoA dehydrogenase activity
AOLE_02415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AOLE_02420	COG1309	transcriptional regulator
AOLE_02435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AOLE_02440	COG1960	acyl-CoA dehydrogenase activity
AOLE_02480	COG2969	positive regulation of protein catabolic process
AOLE_02490	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AOLE_02495	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AOLE_02505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AOLE_02510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AOLE_02530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AOLE_02540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOLE_02545	COG1408	metallophosphoesterase
AOLE_02550	COG2885	chlorophyll binding
AOLE_02555	COG2199	diguanylate cyclase activity
AOLE_02575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOLE_02575	COG3453	Protein conserved in bacteria
AOLE_02590	COG1607	acyl-coa hydrolase
AOLE_02625	COG2350	Protein conserved in bacteria
AOLE_02635	COG0613	PHP domain protein
AOLE_02640	COG3781	membrane
AOLE_02650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AOLE_02665	COG1862	Preprotein translocase
AOLE_02695	COG2205	protein histidine kinase activity
AOLE_02695	COG3437	response regulator, receiver
AOLE_02695	COG3850	Histidine kinase
AOLE_02695	COG4999	Histidine kinase
AOLE_02700	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AOLE_02720	COG0726	polysaccharide deacetylase
AOLE_02725	COG0463	Glycosyl transferase, family 2
AOLE_02730	COG0438	transferase activity, transferring glycosyl groups
AOLE_02760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AOLE_02795	COG1960	acyl-CoA dehydrogenase activity
AOLE_02800	COG1960	acyl-CoA dehydrogenase activity
AOLE_02810	COG2205	protein histidine kinase activity
AOLE_02815	COG0745	RESPONSE REGULATOR receiver
AOLE_02825	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AOLE_02845	COG2096	Adenosyltransferase
AOLE_02850	COG4206	TonB-dependent receptor
AOLE_02860	COG0133	tryptophan synthase activity
AOLE_02895	COG0285	dihydrofolate synthase activity
AOLE_02915	COG0450	alkyl hydroperoxide reductase
AOLE_02930	COG0477	Major facilitator Superfamily
AOLE_02935	COG1272	protein, Hemolysin III
AOLE_02945	COG2153	protein acetylation
AOLE_02965	COG0183	Belongs to the thiolase family
AOLE_02970	COG2207	Transcriptional regulator
AOLE_02990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOLE_03005	COG0183	Belongs to the thiolase family
AOLE_03015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AOLE_03015	COG2885	chlorophyll binding
AOLE_03025	COG1690	Belongs to the RtcB family
AOLE_03030	COG0833	amino acid
AOLE_03040	COG2233	PERMEase
AOLE_03060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOLE_03070	COG2094	Belongs to the DNA glycosylase MPG family
AOLE_03075	COG4772	TonB-dependent receptor
AOLE_03080	COG1902	pentaerythritol trinitrate reductase activity
AOLE_03085	COG0679	Auxin Efflux Carrier
AOLE_03095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOLE_03100	COG0354	folic acid binding
AOLE_03110	COG3189	MarR family transcriptional regulator
AOLE_03115	COG2824	Alkylphosphonate utilization operon protein PhnA
AOLE_03120	COG3422	double-strand break repair
AOLE_03160	COG0840	transmembrane signaling receptor activity
AOLE_03190	COG2832	Protein of unknown function (DUF454)
AOLE_03195	COG1376	ErfK ybiS ycfS ynhG family protein
AOLE_03205	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AOLE_03215	COG1289	transmembrane transporter activity
AOLE_03220	COG2814	Major facilitator Superfamily
AOLE_03235	COG1115	amino acid carrier protein
AOLE_03240	COG1752	Esterase of the alpha-beta hydrolase superfamily
AOLE_03245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AOLE_03250	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AOLE_03280	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AOLE_03290	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AOLE_03295	COG1077	Cell shape determining protein MreB Mrl
AOLE_03300	COG1792	Involved in formation and maintenance of cell shape
AOLE_03305	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AOLE_03310	COG0424	maF-like protein
AOLE_03315	COG1530	ribonuclease E activity
AOLE_03325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AOLE_03375	COG2207	Transcriptional regulator
AOLE_03395	COG1113	amino acid transport
AOLE_03405	COG0142	geranyltranstransferase activity
AOLE_03410	COG2315	Protein conserved in bacteria
AOLE_03425	COG1752	Esterase of the alpha-beta hydrolase superfamily
AOLE_03445	COG2194	sulfuric ester hydrolase activity
AOLE_03450	COG0745	RESPONSE REGULATOR receiver
AOLE_03455	COG0642	Histidine kinase
AOLE_03465	COG0004	ammonium transporteR
AOLE_03470	COG0583	DNA-binding transcription factor activity
AOLE_03495	COG0525	valine-tRNA ligase activity
AOLE_03505	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_03515	COG0393	Putative heavy-metal-binding
AOLE_03520	COG0393	Putative heavy-metal-binding
AOLE_03525	COG1538	Outer membrane efflux protein
AOLE_03535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOLE_03540	COG0671	phosphoesterase, PA-phosphatase related
AOLE_03565	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AOLE_03580	COG1648	precorrin-2 dehydrogenase activity
AOLE_03580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AOLE_03585	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AOLE_03625	COG0531	amino acid
AOLE_03640	COG0321	lipoyl(octanoyl) transferase activity
AOLE_03645	COG2921	Belongs to the UPF0250 family
AOLE_03685	COG2009	succinate dehydrogenase
AOLE_03690	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AOLE_03695	COG1053	succinate dehydrogenase
AOLE_03700	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AOLE_03725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOLE_03745	COG2354	Protein conserved in bacteria
AOLE_03750	COG2321	neutral zinc metallopeptidase
AOLE_03775	COG2843	Capsule synthesis protein
AOLE_03790	COG0589	response to stress
AOLE_03810	COG0505	Belongs to the CarA family
AOLE_03835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOLE_03840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AOLE_03875	COG0477	Major facilitator Superfamily
AOLE_03880	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AOLE_03900	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AOLE_03925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOLE_03930	COG0584	glycerophosphoryl diester phosphodiesterase
AOLE_03950	COG0741	lytic transglycosylase activity
AOLE_03970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOLE_03985	COG0583	DNA-binding transcription factor activity
AOLE_03995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AOLE_04035	COG1309	transcriptional regulator
AOLE_04040	COG1902	pentaerythritol trinitrate reductase activity
AOLE_04045	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOLE_04045	COG0596	Alpha beta hydrolase
AOLE_04050	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOLE_04050	COG0596	Alpha beta hydrolase
AOLE_04055	COG0596	Alpha beta hydrolase
AOLE_04065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOLE_04075	COG0778	Nitroreductase
AOLE_04090	COG1929	Belongs to the glycerate kinase type-1 family
AOLE_04100	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AOLE_04135	COG1113	amino acid transport
AOLE_04145	COG0019	diaminopimelate decarboxylase activity
AOLE_04155	COG2267	carboxylic ester hydrolase activity
AOLE_04160	COG1280	lysine exporter protein (LysE YggA)
AOLE_04165	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AOLE_04190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOLE_04210	COG0463	Glycosyl transferase, family 2
AOLE_04230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOLE_04255	COG0697	spore germination
AOLE_04260	COG4591	ABC-type transport system involved in lipoprotein release permease component
AOLE_04265	COG1136	(ABC) transporter
AOLE_04270	COG2333	competence protein COMEC
AOLE_04270	COG0658	competence protein
AOLE_04280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AOLE_04280	COG0616	signal peptide processing
AOLE_04290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AOLE_04300	COG0628	permease
AOLE_04335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOLE_04355	COG0823	Involved in the tonB-independent uptake of proteins
AOLE_04375	COG0824	Thioesterase
AOLE_04380	COG1473	amidohydrolase
AOLE_04400	COG0047	phosphoribosylformylglycinamidine synthase activity
AOLE_04400	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AOLE_04410	COG2814	Major facilitator Superfamily
AOLE_04420	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AOLE_04425	COG1024	Enoyl-CoA hydratase
AOLE_04430	COG1056	cytidyltransferase-related domain
AOLE_04430	COG1051	belongs to the nudix hydrolase family
AOLE_04450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AOLE_04465	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AOLE_04470	COG0602	queuosine metabolic process
AOLE_04480	COG4625	pathogenesis
AOLE_04485	COG0583	DNA-binding transcription factor activity
AOLE_04490	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AOLE_04495	COG4208	sulfate ABC transporter
AOLE_04500	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AOLE_04510	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AOLE_04515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AOLE_04520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AOLE_04540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOLE_04550	COG0481	GTPase activity
AOLE_04555	COG0681	Belongs to the peptidase S26 family
AOLE_04565	COG0571	ribonuclease III activity
AOLE_04570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AOLE_04585	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AOLE_04595	COG4221	oxidoreductase activity
AOLE_04635	COG0556	nucleotide-excision repair
AOLE_04690	COG2070	2-Nitropropane dioxygenase
AOLE_04715	COG1215	transferase activity, transferring glycosyl groups
AOLE_04730	COG0415	Belongs to the DNA photolyase family
AOLE_04740	COG1252	NADH dehydrogenase
AOLE_04745	COG1686	Belongs to the peptidase S11 family
AOLE_04760	COG1187	pseudouridine synthase activity
AOLE_04775	COG0477	Major facilitator Superfamily
AOLE_04780	COG0583	DNA-binding transcription factor activity
AOLE_04795	COG0612	Peptidase, M16
AOLE_04820	COG0352	thiamine-phosphate diphosphorylase activity
AOLE_04855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOLE_04880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AOLE_04885	COG0076	glutamate decarboxylase activity
AOLE_04895	COG1522	sequence-specific DNA binding
AOLE_04900	COG3961	Belongs to the TPP enzyme family
AOLE_04905	COG1113	amino acid transport
AOLE_04910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AOLE_04915	COG0573	inorganic phosphate transmembrane transporter activity
AOLE_04925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AOLE_04930	COG0616	signal peptide processing
AOLE_04970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AOLE_04975	COG1686	Belongs to the peptidase S11 family
AOLE_05000	COG0583	DNA-binding transcription factor activity
AOLE_05005	COG1067	ATP-dependent peptidase activity
AOLE_05010	COG2211	Major facilitator Superfamily
AOLE_05045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AOLE_05050	COG1966	Carbon starvation protein
AOLE_05055	COG2879	small protein
AOLE_05065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AOLE_05110	COG1278	Cold shock
AOLE_05130	COG1309	transcriptional regulator
AOLE_05190	COG1741	Belongs to the pirin family
AOLE_05205	COG3739	integral membrane protein
AOLE_05235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AOLE_05260	COG0512	Glutamine amidotransferase of anthranilate synthase
AOLE_05270	COG3104	oligopeptide transport
AOLE_05285	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AOLE_05305	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AOLE_05310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AOLE_05315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOLE_05325	COG0280	phosphate acetyltransferase
AOLE_05325	COG0281	malic enzyme
AOLE_05335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AOLE_05340	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AOLE_05345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AOLE_05365	COG1960	acyl-CoA dehydrogenase activity
AOLE_05370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AOLE_05375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOLE_05390	COG2223	nitrite transmembrane transporter activity
AOLE_05400	COG0024	Methionine aminopeptidase
AOLE_05405	COG0052	Belongs to the universal ribosomal protein uS2 family
AOLE_05420	COG2207	Transcriptional regulator
AOLE_05445	COG2951	lytic endotransglycosylase activity
AOLE_05450	COG0772	Belongs to the SEDS family
AOLE_05465	COG0842	Transport permease protein
AOLE_05470	COG1131	(ABC) transporter
AOLE_05495	COG1538	Outer membrane efflux protein
AOLE_05505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOLE_05520	COG4215	(ABC) transporter
AOLE_05525	COG4160	amino acid transport
AOLE_05530	COG4598	ABC transporter
AOLE_05540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AOLE_05550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOLE_05555	COG0384	phenazine biosynthesis protein PhzF
AOLE_05565	COG1720	tRNA m6t6A37 methyltransferase activity
AOLE_05575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AOLE_05585	COG0745	RESPONSE REGULATOR receiver
AOLE_05590	COG0642	Histidine kinase
AOLE_05600	COG0494	nUDIX hydrolase
AOLE_05610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOLE_05615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AOLE_05620	COG3139	Protein of unknown function (DUF1315)
AOLE_05630	COG1301	dicarboxylic acid transport
AOLE_05635	COG1960	acyl-CoA dehydrogenase activity
AOLE_05645	COG2819	hydrolase of the alpha beta superfamily
AOLE_05655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AOLE_05665	COG2195	Cleaves the N-terminal amino acid of tripeptides
AOLE_05690	COG1690	Belongs to the RtcB family
AOLE_05695	COG1234	tRNA 3'-trailer cleavage
AOLE_05700	COG4650	regulator
AOLE_05730	COG2363	Small membrane protein
AOLE_05750	COG0513	Belongs to the DEAD box helicase family
AOLE_05760	COG0778	Nitroreductase
AOLE_05790	COG1286	toxin biosynthetic process
AOLE_05815	COG4783	chaperone-mediated protein folding
AOLE_05820	COG1610	YqeY-like protein
AOLE_05825	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AOLE_05850	COG2815	serine threonine protein kinase
AOLE_05850	COG0515	serine threonine protein kinase
AOLE_05855	COG1278	Cold shock
AOLE_05880	COG0534	Mate efflux family protein
AOLE_05900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOLE_05905	COG4221	oxidoreductase activity
AOLE_05910	COG1733	regulation of RNA biosynthetic process
AOLE_05915	COG2085	NADP oxidoreductase coenzyme F420-dependent
AOLE_05945	COG3243	poly(R)-hydroxyalkanoic acid synthase
AOLE_05950	COG0786	glutamate:sodium symporter activity
AOLE_05955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AOLE_05955	COG0475	glutathione-regulated potassium exporter activity
AOLE_05960	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_05985	COG2985	domain, Protein
AOLE_05995	COG2995	paraquat-inducible protein a
AOLE_06000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AOLE_06000	COG3008	intermembrane lipid transfer
AOLE_06010	COG2351	hydroxyisourate hydrolase activity
AOLE_06025	COG5002	protein histidine kinase activity
AOLE_06050	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AOLE_06060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AOLE_06065	COG0642	Histidine kinase
AOLE_06070	COG0745	RESPONSE REGULATOR receiver
AOLE_06085	COG1794	racemase activity, acting on amino acids and derivatives
AOLE_06095	COG2175	clavaminate synthase activity
AOLE_06100	COG3246	L-lysine catabolic process to acetate
AOLE_06105	COG2814	Major facilitator Superfamily
AOLE_06120	COG2855	membrane
AOLE_06155	COG2814	Major facilitator Superfamily
AOLE_06170	COG0625	glutathione transferase activity
AOLE_06185	COG1301	dicarboxylic acid transport
AOLE_06200	COG2011	ABC-type metal ion transport system permease component
AOLE_06205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AOLE_06210	COG1464	Belongs to the NlpA lipoprotein family
AOLE_06215	COG0151	Belongs to the GarS family
AOLE_06225	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AOLE_06270	COG1305	Transglutaminase-like
AOLE_06280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AOLE_06285	COG0305	Participates in initiation and elongation during chromosome replication
AOLE_06310	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AOLE_06320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AOLE_06325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AOLE_06350	COG1649	PFAM Uncharacterised BCR, COG1649
AOLE_06350	COG0726	polysaccharide deacetylase
AOLE_06355	COG1215	transferase activity, transferring glycosyl groups
AOLE_06360	COG3658	cytochrome
AOLE_06370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOLE_06390	COG2890	protein-(glutamine-N5) methyltransferase activity
AOLE_06395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOLE_06400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOLE_06415	COG1960	acyl-CoA dehydrogenase activity
AOLE_06420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOLE_06435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AOLE_06445	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AOLE_06450	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AOLE_06460	COG2205	protein histidine kinase activity
AOLE_06465	COG0745	RESPONSE REGULATOR receiver
AOLE_06470	COG0174	glutamine synthetase
AOLE_06485	COG0477	Major facilitator Superfamily
AOLE_06490	COG0729	surface antigen
AOLE_06520	COG0471	metal ion transport
AOLE_06530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOLE_06535	COG2814	Major facilitator Superfamily
AOLE_06550	COG0583	DNA-binding transcription factor activity
AOLE_06565	COG1187	pseudouridine synthase activity
AOLE_06585	COG0802	atpase or kinase
AOLE_06590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AOLE_06600	COG1923	regulation of RNA biosynthetic process
AOLE_06605	COG0697	spore germination
AOLE_06630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOLE_06635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AOLE_06635	COG0519	Catalyzes the synthesis of GMP from XMP
AOLE_06640	COG4302	ethanolamine ammonia-lyase activity
AOLE_06645	COG4303	Ethanolamine ammonia lyase large subunit
AOLE_06650	COG0531	amino acid
AOLE_06670	COG1454	alcohol dehydrogenase
AOLE_06675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AOLE_06685	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AOLE_06705	COG0308	aminopeptidase N
AOLE_06745	COG1605	Chorismate mutase
AOLE_06750	COG1309	transcriptional regulator
AOLE_06800	COG1733	regulation of RNA biosynthetic process
AOLE_06825	COG0583	DNA-binding transcription factor activity
AOLE_06840	COG3111	PFAM Bacterial OB fold (BOF) protein
AOLE_06860	COG0488	(ABC) transporter
AOLE_06865	COG0589	response to stress
AOLE_06885	COG3135	benzoate transporter
AOLE_06890	COG1522	sequence-specific DNA binding
AOLE_06905	COG0583	DNA-binding transcription factor activity
AOLE_06915	COG0183	Belongs to the thiolase family
AOLE_06920	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_06955	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AOLE_06965	COG0824	Thioesterase
AOLE_06970	COG1454	alcohol dehydrogenase
AOLE_07000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AOLE_07030	COG0069	glutamate synthase activity
AOLE_07060	COG2814	Major facilitator Superfamily
AOLE_07075	COG0511	ligase activity, forming carbon-carbon bonds
AOLE_07100	COG4264	IucA IucC family
AOLE_07110	COG4264	IucA IucC family
AOLE_07115	COG2423	ornithine cyclodeaminase activity
AOLE_07120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AOLE_07130	COG1116	anion transmembrane transporter activity
AOLE_07130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOLE_07135	COG0745	RESPONSE REGULATOR receiver
AOLE_07145	COG2146	nitrite reductase [NAD(P)H] activity
AOLE_07145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOLE_07150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOLE_07155	COG0243	molybdopterin cofactor binding
AOLE_07165	COG0243	molybdopterin cofactor binding
AOLE_07170	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AOLE_07185	COG0521	Mo-molybdopterin cofactor biosynthetic process
AOLE_07185	COG0315	cyclic pyranopterin monophosphate synthase activity
AOLE_07190	COG0303	'Molybdopterin
AOLE_07200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOLE_07205	COG0697	spore germination
AOLE_07230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AOLE_07250	COG1335	isochorismatase
AOLE_07290	COG2204	response regulator
AOLE_07320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AOLE_07325	COG0575	Belongs to the CDS family
AOLE_07340	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOLE_07360	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOLE_07370	COG2137	regulation of response to DNA damage stimulus
AOLE_07380	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AOLE_07385	COG1011	Hydrolase
AOLE_07430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOLE_07510	COG1484	DNA-dependent DNA replication
AOLE_07605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOLE_07625	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AOLE_07630	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_07635	COG3118	belongs to the thioredoxin family
AOLE_07640	COG1902	pentaerythritol trinitrate reductase activity
AOLE_07650	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AOLE_07660	COG2814	Major facilitator Superfamily
AOLE_07665	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AOLE_07675	COG1294	oxidase, subunit
AOLE_07680	COG1271	oxidase subunit
AOLE_07695	COG4771	TonB-dependent receptor
AOLE_07890	COG0592	DNA-directed DNA polymerase activity
AOLE_07965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AOLE_07995	COG1522	sequence-specific DNA binding
AOLE_08005	COG1113	amino acid transport
AOLE_08025	COG0659	secondary active sulfate transmembrane transporter activity
AOLE_08045	COG5001	Diguanylate cyclase
AOLE_08045	COG3300	MHYT domain
AOLE_08065	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AOLE_08065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOLE_08065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOLE_08070	COG1105	Belongs to the carbohydrate kinase PfkB family
AOLE_08075	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOLE_08075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AOLE_08105	COG0024	Methionine aminopeptidase
AOLE_08110	COG0583	DNA-binding transcription factor activity
AOLE_08125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOLE_08130	COG0517	IMP dehydrogenase activity
AOLE_08130	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AOLE_08155	COG0552	protein localization to endoplasmic reticulum
AOLE_08180	COG4890	Cyd operon protein YbgT
AOLE_08185	COG1294	oxidase, subunit
AOLE_08200	COG1585	Membrane protein implicated in regulation of membrane protease activity
AOLE_08210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOLE_08235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AOLE_08240	COG0569	domain protein
AOLE_08245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AOLE_08275	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AOLE_08280	COG0542	response to heat
AOLE_08290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AOLE_08305	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOLE_08305	COG1902	pentaerythritol trinitrate reductase activity
AOLE_08350	COG0148	phosphopyruvate hydratase activity
AOLE_08355	COG2323	membrane
AOLE_08370	COG4773	Receptor
AOLE_08380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AOLE_08390	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AOLE_08395	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AOLE_08400	COG0183	Belongs to the thiolase family
AOLE_08405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AOLE_08410	COG0596	Alpha beta hydrolase
AOLE_08415	COG2271	Major facilitator Superfamily
AOLE_08420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AOLE_08425	COG3485	protocatechuate 3,4-dioxygenase
AOLE_08430	COG3485	protocatechuate 3,4-dioxygenase
AOLE_08435	COG0710	3-dehydroquinate dehydratase activity
AOLE_08440	COG3420	alginic acid biosynthetic process
AOLE_08445	COG3659	wide pore channel activity
AOLE_08450	COG4993	Dehydrogenase
AOLE_08460	COG2391	methyltransferase activity
AOLE_08475	COG1414	Transcriptional regulator
AOLE_08480	COG0583	DNA-binding transcription factor activity
AOLE_08485	COG1960	acyl-CoA dehydrogenase activity
AOLE_08510	COG2814	Major facilitator Superfamily
AOLE_08520	COG0154	amidase activity
AOLE_08540	COG4638	Rieske (2fe-2S)
AOLE_08550	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_08560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOLE_08570	COG3733	amine oxidase
AOLE_08585	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_08595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOLE_08600	COG0183	Belongs to the thiolase family
AOLE_08605	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AOLE_08610	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AOLE_08620	COG4829	muconolactone delta-isomerase
AOLE_08625	COG4948	Mandelate Racemase Muconate Lactonizing
AOLE_08630	COG0583	DNA-binding transcription factor activity
AOLE_08640	COG0583	DNA-binding transcription factor activity
AOLE_08645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOLE_08650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOLE_08695	COG3829	transcription factor binding
AOLE_08705	COG3829	transcription factor binding
AOLE_08710	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_08715	COG1414	Transcriptional regulator
AOLE_08735	COG3659	wide pore channel activity
AOLE_08740	COG1309	transcriptional regulator
AOLE_08765	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AOLE_08775	COG1053	succinate dehydrogenase
AOLE_08780	COG1053	succinate dehydrogenase
AOLE_08810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AOLE_08845	COG1309	transcriptional regulator
AOLE_08855	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_08860	COG4689	acetoacetate decarboxylase
AOLE_08870	COG1902	pentaerythritol trinitrate reductase activity
AOLE_08885	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_08910	COG0318	PFAM AMP-dependent synthetase and ligase
AOLE_08935	COG1902	pentaerythritol trinitrate reductase activity
AOLE_08945	COG1733	regulation of RNA biosynthetic process
AOLE_08950	COG0702	epimerase
AOLE_08965	COG1309	transcriptional regulator
AOLE_09010	COG3047	cAMP biosynthetic process
AOLE_09010	COG2885	chlorophyll binding
AOLE_09020	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AOLE_09035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AOLE_09040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AOLE_09060	COG2831	hemolysin activation secretion protein
AOLE_09065	COG3210	domain, Protein
AOLE_09105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOLE_09120	COG2271	Major facilitator Superfamily
AOLE_09130	COG1566	PFAM secretion protein HlyD family protein
AOLE_09145	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_09150	COG0129	dihydroxy-acid dehydratase activity
AOLE_09160	COG0583	DNA-binding transcription factor activity
AOLE_09165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AOLE_09175	COG2084	Dehydrogenase
AOLE_09180	COG2207	Transcriptional regulator
AOLE_09185	COG1064	alcohol dehydrogenase
AOLE_09195	COG1309	transcriptional regulator
AOLE_09215	COG1120	ATPase activity
AOLE_09235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AOLE_09315	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AOLE_09385	COG1414	Transcriptional regulator
AOLE_09390	COG2851	Citrate transporter
AOLE_09400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AOLE_09405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOLE_09435	COG2259	Doxx family
AOLE_09440	COG0583	DNA-binding transcription factor activity
AOLE_09445	COG2205	protein histidine kinase activity
AOLE_09450	COG0745	RESPONSE REGULATOR receiver
AOLE_09455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOLE_09460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOLE_09465	COG1538	Outer membrane efflux protein
AOLE_09490	COG2072	flavoprotein involved in K transport
AOLE_09500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOLE_09520	COG4628	conserved protein (DUF2132)
AOLE_09530	COG2175	clavaminate synthase activity
AOLE_09535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOLE_09550	COG0667	Aldo Keto reductase
AOLE_09570	COG2175	clavaminate synthase activity
AOLE_09600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOLE_09605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOLE_09640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOLE_09645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOLE_09655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOLE_09670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AOLE_09685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOLE_09700	COG1132	(ABC) transporter
AOLE_09705	COG1132	(ABC) transporter
AOLE_09725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AOLE_09730	COG0601	transmembrane transport
AOLE_09765	COG3539	Fimbrial protein
AOLE_09790	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AOLE_09800	COG0753	catalase activity
AOLE_09820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOLE_09880	COG4771	TonB-dependent receptor
AOLE_09885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOLE_09890	COG1535	isochorismatase
AOLE_09890	COG3433	isochorismatase activity
AOLE_09895	COG1021	2,3-dihydroxybenzoate-AMP ligase
AOLE_09900	COG1169	isochorismate synthase
AOLE_09905	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_09915	COG3251	PFAM MbtH domain protein
AOLE_09920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AOLE_09950	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AOLE_09955	COG4149	molybdate abc transporter
AOLE_09960	COG0725	ABC transporter, periplasmic molybdate-binding protein
AOLE_09970	COG4638	Rieske (2fe-2S)
AOLE_09975	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AOLE_09980	COG0543	2 iron, 2 sulfur cluster binding
AOLE_09980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOLE_09995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOLE_10005	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_10010	COG0412	Dienelactone hydrolase
AOLE_10025	COG2207	Transcriptional regulator
AOLE_10030	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_10035	COG2610	gluconate transmembrane transporter activity
AOLE_10040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOLE_10070	COG2814	Major facilitator Superfamily
AOLE_10090	COG0583	DNA-binding transcription factor activity
AOLE_10110	COG2031	fatty acid transporter
AOLE_10115	COG0183	Belongs to the thiolase family
AOLE_10120	COG0583	DNA-binding transcription factor activity
AOLE_10125	COG0583	DNA-binding transcription factor activity
AOLE_10140	COG1027	Aspartate ammonia-lyase
AOLE_10150	COG0477	Major facilitator Superfamily
AOLE_10170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOLE_10175	COG4521	taurine ABC transporter
AOLE_10195	COG3708	Transcriptional regulator
AOLE_10195	COG2207	Transcriptional regulator
AOLE_10210	COG0730	response to heat
AOLE_10220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOLE_10220	COG3453	Protein conserved in bacteria
AOLE_10230	COG3781	membrane
AOLE_10235	COG1063	alcohol dehydrogenase
AOLE_10245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOLE_10250	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOLE_10255	COG0022	dehydrogenase e1 component
AOLE_10260	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AOLE_10265	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AOLE_10280	COG3706	GGDEF domain
AOLE_10300	COG0133	tryptophan synthase activity
AOLE_10310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOLE_10340	COG0583	DNA-binding transcription factor activity
AOLE_10350	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AOLE_10360	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AOLE_10400	COG0537	adenosine 5'-monophosphoramidase activity
AOLE_10425	COG0842	Transport permease protein
AOLE_10430	COG0842	Transport permease protein
AOLE_10435	COG1131	(ABC) transporter
AOLE_10450	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOLE_10455	COG4773	Receptor
AOLE_10475	COG0730	response to heat
AOLE_10480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AOLE_10495	COG0406	alpha-ribazole phosphatase activity
AOLE_10500	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AOLE_10515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AOLE_10525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AOLE_10540	COG1960	acyl-CoA dehydrogenase activity
AOLE_10545	COG1960	acyl-CoA dehydrogenase activity
AOLE_10550	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOLE_10555	COG2207	Transcriptional regulator
AOLE_10560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOLE_10565	COG0776	regulation of translation
AOLE_10590	COG0822	iron-sulfur transferase activity
AOLE_10595	COG0316	Belongs to the HesB IscA family
AOLE_10625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AOLE_10645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AOLE_10650	COG0702	epimerase
AOLE_10690	COG0601	transmembrane transport
AOLE_10695	COG0339	signal peptide processing
AOLE_10700	COG4166	transmembrane transport
AOLE_10715	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AOLE_10740	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AOLE_10745	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AOLE_10760	COG2431	L-lysine efflux transmembrane transporter activity
AOLE_10775	COG0776	regulation of translation
AOLE_10795	COG0590	tRNA wobble adenosine to inosine editing
AOLE_10840	COG0084	hydrolase, TatD family'
AOLE_10860	COG1663	tetraacyldisaccharide 4'-kinase activity
AOLE_10865	COG1132	(ABC) transporter
AOLE_10875	COG0811	peptide transport
AOLE_10880	COG1475	DNA binding
AOLE_10885	COG1192	Involved in chromosome partitioning
AOLE_10895	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AOLE_10910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOLE_10915	COG0191	fructose-bisphosphate aldolase activity
AOLE_10935	COG0424	maF-like protein
AOLE_10940	COG2850	peptidyl-arginine hydroxylation
AOLE_10950	COG0640	Transcriptional regulator
AOLE_10960	COG3619	membrane
AOLE_10965	COG3122	Protein conserved in bacteria
AOLE_10970	COG1132	(ABC) transporter
AOLE_10990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AOLE_10995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOLE_11005	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AOLE_11005	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AOLE_11005	COG0506	proline dehydrogenase activity
AOLE_11010	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AOLE_11025	COG3698	Phosphodiester glycosidase
AOLE_11035	COG2353	YceI-like domain
AOLE_11045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AOLE_11090	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AOLE_11090	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AOLE_11115	COG3539	Fimbrial protein
AOLE_11145	COG0583	DNA-binding transcription factor activity
AOLE_11150	COG0697	spore germination
AOLE_11160	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AOLE_11170	COG0583	DNA-binding transcription factor activity
AOLE_11180	COG1309	transcriptional regulator
AOLE_11195	COG1522	sequence-specific DNA binding
AOLE_11205	COG1126	abc transporter atp-binding protein
AOLE_11210	COG0765	amino acid transport
AOLE_11215	COG0765	amino acid transport
AOLE_11245	COG1464	Belongs to the NlpA lipoprotein family
AOLE_11255	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AOLE_11260	COG2011	ABC-type metal ion transport system permease component
AOLE_11265	COG0012	GTP binding
AOLE_11295	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AOLE_11330	COG2207	Transcriptional regulator
AOLE_11330	COG1917	Cupin 2, conserved barrel domain protein
AOLE_11335	COG0386	Belongs to the glutathione peroxidase family
AOLE_11345	COG0436	Aminotransferase
AOLE_11350	COG1301	dicarboxylic acid transport
AOLE_11385	COG3634	alkyl hydroperoxide reductase activity
AOLE_11400	COG0583	DNA-binding transcription factor activity
AOLE_11405	COG0798	PFAM Bile acid sodium symporter
AOLE_11410	COG0640	Transcriptional regulator
AOLE_11425	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AOLE_11435	COG0583	DNA-binding transcription factor activity
AOLE_11445	COG1953	Uracil, thiamine, allantoin
AOLE_11455	COG2175	clavaminate synthase activity
AOLE_11460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOLE_11465	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AOLE_11470	COG4521	taurine ABC transporter
AOLE_11480	COG0477	Major facilitator Superfamily
AOLE_11500	COG1271	oxidase subunit
AOLE_11505	COG1294	oxidase, subunit
AOLE_11515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOLE_11535	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AOLE_11555	COG3052	prosthetic group binding
AOLE_11560	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AOLE_11570	COG2814	Major facilitator Superfamily
AOLE_11585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOLE_11590	COG1346	cytolysis
AOLE_11600	COG0583	DNA-binding transcription factor activity
AOLE_11605	COG0625	glutathione transferase activity
AOLE_11610	COG0625	glutathione transferase activity
AOLE_11630	COG0583	DNA-binding transcription factor activity
AOLE_11645	COG1045	serine acetyltransferase
AOLE_11650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOLE_11655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AOLE_11660	COG1280	lysine exporter protein (LysE YggA)
AOLE_11670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOLE_11675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOLE_11685	COG0765	amino acid transport
AOLE_11690	COG0765	amino acid transport
AOLE_11725	COG0784	Response regulator, receiver
AOLE_11725	COG2205	protein histidine kinase activity
AOLE_11745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AOLE_11765	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_11810	COG0583	DNA-binding transcription factor activity
AOLE_11820	COG2814	Major facilitator Superfamily
AOLE_11835	COG0318	PFAM AMP-dependent synthetase and ligase
AOLE_11840	COG1309	transcriptional regulator
AOLE_11845	COG1960	acyl-CoA dehydrogenase activity
AOLE_11850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AOLE_11855	COG1024	Enoyl-CoA hydratase
AOLE_11870	COG0583	DNA-binding transcription factor activity
AOLE_11885	COG1960	acyl-CoA dehydrogenase activity
AOLE_11895	COG2814	Major facilitator Superfamily
AOLE_11905	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AOLE_11910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AOLE_11915	COG2814	Major facilitator Superfamily
AOLE_11920	COG1960	acyl-CoA dehydrogenase activity
AOLE_11925	COG1024	Enoyl-CoA hydratase
AOLE_11930	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_11935	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOLE_11940	COG0183	Belongs to the thiolase family
AOLE_11950	COG2814	Major facilitator Superfamily
AOLE_11960	COG1024	Enoyl-CoA hydratase
AOLE_11970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOLE_11975	COG1960	acyl-CoA dehydrogenase activity
AOLE_11980	COG2814	Major facilitator Superfamily
AOLE_11985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AOLE_11990	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AOLE_12010	COG3842	ATPase activity
AOLE_12015	COG1840	ABC-type Fe3 transport system, periplasmic component
AOLE_12025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOLE_12030	COG1414	Transcriptional regulator
AOLE_12040	COG0583	DNA-binding transcription factor activity
AOLE_12050	COG1469	GTP cyclohydrolase I activity
AOLE_12060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AOLE_12065	COG1760	l-serine dehydratase
AOLE_12070	COG0531	amino acid
AOLE_12075	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_12100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOLE_12120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOLE_12135	COG0789	Transcriptional regulator
AOLE_12145	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AOLE_12150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOLE_12165	COG2807	transmembrane transport
AOLE_12170	COG0590	tRNA wobble adenosine to inosine editing
AOLE_12175	COG0666	response to abiotic stimulus
AOLE_12180	COG0583	DNA-binding transcription factor activity
AOLE_12220	COG2885	chlorophyll binding
AOLE_12325	COG3209	COG3209 Rhs family protein
AOLE_12350	COG0477	Major facilitator Superfamily
AOLE_12365	COG1116	anion transmembrane transporter activity
AOLE_12370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOLE_12380	COG0864	Transcriptional regulator
AOLE_12390	COG1733	regulation of RNA biosynthetic process
AOLE_12395	COG2249	NAD(P)H dehydrogenase (quinone) activity
AOLE_12400	COG0439	Biotin carboxylase
AOLE_12415	COG1063	alcohol dehydrogenase
AOLE_12420	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOLE_12480	COG0038	chloride channel
AOLE_12485	COG4770	biotin carboxylase activity
AOLE_12505	COG1914	H( )-stimulated, divalent metal cation uptake system
AOLE_12520	COG1595	DNA-templated transcription, initiation
AOLE_12530	COG3220	belongs to the UPF0276 family
AOLE_12545	COG0300	oxidoreductase activity
AOLE_12595	COG1309	transcriptional regulator
AOLE_12605	COG1073	alpha beta
AOLE_12610	COG1073	alpha beta
AOLE_12620	COG1051	belongs to the nudix hydrolase family
AOLE_12625	COG1309	transcriptional regulator
AOLE_12655	COG1595	DNA-templated transcription, initiation
AOLE_12660	COG3712	iron ion homeostasis
AOLE_12680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AOLE_12685	COG4774	siderophore transport
AOLE_12705	COG4521	taurine ABC transporter
AOLE_12710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOLE_12715	COG1116	anion transmembrane transporter activity
AOLE_12720	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AOLE_12730	COG2271	Major facilitator Superfamily
AOLE_12735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AOLE_12740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOLE_12745	COG0583	DNA-binding transcription factor activity
AOLE_12750	COG3038	cytochrome b561
AOLE_12755	COG0753	catalase activity
AOLE_12780	COG1278	Cold shock
AOLE_12815	COG1522	sequence-specific DNA binding
AOLE_12820	COG0531	amino acid
AOLE_12825	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AOLE_12840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AOLE_12875	COG2050	protein possibly involved in aromatic compounds catabolism
AOLE_12885	COG3327	negative regulation of DNA-templated transcription, initiation
AOLE_12890	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AOLE_12895	COG0183	Belongs to the thiolase family
AOLE_12900	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOLE_12905	COG1024	Enoyl-CoA hydratase
AOLE_12910	COG1024	Enoyl-CoA hydratase
AOLE_12915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOLE_12920	COG2151	metal-sulfur cluster biosynthetic enzyme
AOLE_12925	COG3396	Phenylacetate-CoA oxygenase
AOLE_12930	COG3460	Phenylacetate-CoA oxygenase
AOLE_12935	COG3396	Phenylacetate-CoA oxygenase
AOLE_12940	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_12940	COG2030	dehydratase
AOLE_12965	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AOLE_12975	COG4122	O-methyltransferase activity
AOLE_13010	COG1137	ATPase activity
AOLE_13015	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AOLE_13025	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AOLE_13080	COG1733	regulation of RNA biosynthetic process
AOLE_13085	COG2814	Major facilitator Superfamily
AOLE_13120	COG0668	transmembrane transport
AOLE_13180	COG2226	methyltransferase
AOLE_13200	COG1278	Cold shock
AOLE_13205	COG1560	Kdo2-lipid A biosynthetic process
AOLE_13210	COG1280	lysine exporter protein (LysE YggA)
AOLE_13240	COG1570	exodeoxyribonuclease VII activity
AOLE_13270	COG3791	Glutathione-dependent formaldehyde-activating
AOLE_13320	COG2871	sodium ion transport
AOLE_13330	COG0583	DNA-binding transcription factor activity
AOLE_13335	COG4638	Rieske (2fe-2S)
AOLE_13340	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AOLE_13345	COG0543	2 iron, 2 sulfur cluster binding
AOLE_13345	COG0633	Ferredoxin
AOLE_13350	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_13355	COG3135	benzoate transporter
AOLE_13360	COG2814	Major facilitator Superfamily
AOLE_13375	COG1643	Atp-dependent helicase
AOLE_13380	COG0450	alkyl hydroperoxide reductase
AOLE_13390	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOLE_13410	COG3634	alkyl hydroperoxide reductase activity
AOLE_13430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AOLE_13455	COG0625	glutathione transferase activity
AOLE_13465	COG2885	chlorophyll binding
AOLE_13500	COG0542	response to heat
AOLE_13515	COG1765	OsmC-like protein
AOLE_13525	COG0667	Aldo Keto reductase
AOLE_13540	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AOLE_13555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AOLE_13575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AOLE_13585	COG3038	cytochrome b561
AOLE_13590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AOLE_13595	COG2252	PERMEase
AOLE_13610	COG1741	Belongs to the pirin family
AOLE_13615	COG1309	transcriptional regulator
AOLE_13635	COG2072	flavoprotein involved in K transport
AOLE_13640	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AOLE_13645	COG0583	DNA-binding transcription factor activity
AOLE_13655	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AOLE_13690	COG1944	ATP diphosphatase activity
AOLE_13710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AOLE_13725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOLE_13740	COG2814	Major facilitator Superfamily
AOLE_13745	COG1024	Enoyl-CoA hydratase
AOLE_13750	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_13760	COG1960	acyl-CoA dehydrogenase activity
AOLE_13785	COG2186	Transcriptional regulator
AOLE_13790	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_13800	COG4948	Mandelate Racemase Muconate Lactonizing
AOLE_13805	COG2271	Major facilitator Superfamily
AOLE_13810	COG2721	sulfolactate sulfo-lyase activity
AOLE_13815	COG0697	spore germination
AOLE_13870	COG3210	domain, Protein
AOLE_13875	COG2831	hemolysin activation secretion protein
AOLE_13880	COG1113	amino acid transport
AOLE_13900	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_13920	COG0531	amino acid
AOLE_13930	COG1113	amino acid transport
AOLE_13970	COG1309	transcriptional regulator
AOLE_13980	COG4269	membrane
AOLE_14005	COG1902	pentaerythritol trinitrate reductase activity
AOLE_14005	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOLE_14015	COG2203	Gaf domain
AOLE_14015	COG5001	Diguanylate cyclase
AOLE_14015	COG4251	negative regulation of phosphorylation
AOLE_14015	COG3706	GGDEF domain
AOLE_14025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOLE_14045	COG4172	Belongs to the ABC transporter superfamily
AOLE_14050	COG4239	(ABC) transporter, permease
AOLE_14055	COG4174	ABC transporter (Permease)
AOLE_14060	COG4166	transmembrane transport
AOLE_14065	COG0741	lytic transglycosylase activity
AOLE_14065	COG0741	lytic transglycosylase activity
AOLE_14065	COG1388	LysM domain
AOLE_14065	COG1388	LysM domain
AOLE_14070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOLE_14110	COG0583	DNA-binding transcription factor activity
AOLE_14115	COG1279	arginine transmembrane transporter activity
AOLE_14125	COG0789	Transcriptional regulator
AOLE_14135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOLE_14140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOLE_14145	COG0006	proline dipeptidase activity
AOLE_14180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AOLE_14195	COG3384	dioxygenase
AOLE_14205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AOLE_14210	COG2878	Part of a membrane complex involved in electron transport
AOLE_14215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AOLE_14240	COG0768	penicillin binding
AOLE_14245	COG0742	ribosomal rna small subunit methyltransferase
AOLE_14260	COG0830	nickel cation binding
AOLE_14270	COG0804	urea catabolic process
AOLE_14295	COG3015	lipoprotein NlpE involved in copper resistance
AOLE_14310	COG1253	flavin adenine dinucleotide binding
AOLE_14315	COG2851	Citrate transporter
AOLE_14365	COG1773	rubredoxin
AOLE_14370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOLE_14380	COG0583	DNA-binding transcription factor activity
AOLE_14405	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AOLE_14410	COG4181	ATPase activity
AOLE_14455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AOLE_14475	COG0306	phosphate transporter
AOLE_14490	COG3958	Transketolase
AOLE_14495	COG3959	Transketolase, thiamine diphosphate binding domain
AOLE_14500	COG2271	Major facilitator Superfamily
AOLE_14505	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_14510	COG0583	DNA-binding transcription factor activity
AOLE_14525	COG2223	nitrite transmembrane transporter activity
AOLE_14535	COG2066	Belongs to the glutaminase family
AOLE_14540	COG0242	peptide deformylase activity
AOLE_14545	COG0477	Major facilitator Superfamily
AOLE_14555	COG0028	Belongs to the TPP enzyme family
AOLE_14570	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_14575	COG2267	carboxylic ester hydrolase activity
AOLE_14585	COG2271	Major facilitator Superfamily
AOLE_14600	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_14620	COG1414	Transcriptional regulator
AOLE_14640	COG1024	Enoyl-CoA hydratase
AOLE_14650	COG1309	transcriptional regulator
AOLE_14660	COG1215	transferase activity, transferring glycosyl groups
AOLE_14665	COG1649	PFAM Uncharacterised BCR, COG1649
AOLE_14665	COG0726	polysaccharide deacetylase
AOLE_14675	COG4681	YaeQ
AOLE_14685	COG0523	cobalamin synthesis protein
AOLE_14695	COG1607	acyl-coa hydrolase
AOLE_14705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOLE_14710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOLE_14715	COG1309	transcriptional regulator
AOLE_14740	COG2040	homocysteine
AOLE_14745	COG0531	amino acid
AOLE_14800	COG1595	DNA-templated transcription, initiation
AOLE_14810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOLE_14815	COG0477	Major facilitator Superfamily
AOLE_15000	COG3566	protein conserved in bacteria
AOLE_15020	COG3567	Phage-associated protein, HI1409 family
AOLE_15025	COG5410	chromosome segregation
AOLE_15100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AOLE_15135	COG1674	ftsk spoiiie
AOLE_15155	COG0405	Gamma-glutamyltransferase
AOLE_15160	COG2814	Major facilitator Superfamily
AOLE_15165	COG1566	PFAM secretion protein HlyD family protein
AOLE_15170	COG2050	protein possibly involved in aromatic compounds catabolism
AOLE_15185	COG1090	epimerase
AOLE_15205	COG0420	3'-5' exonuclease activity
AOLE_15215	COG1968	undecaprenyl-diphosphatase activity
AOLE_15235	COG0735	belongs to the Fur family
AOLE_15240	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOLE_15245	COG2914	Belongs to the UPF0125 (RnfH) family
AOLE_15260	COG0121	glutamine amidotransferase
AOLE_15275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOLE_15285	COG0210	DNA helicase
AOLE_15295	COG2885	chlorophyll binding
AOLE_15300	COG0204	Acyl-transferase
AOLE_15330	COG1280	lysine exporter protein (LysE YggA)
AOLE_15335	COG1674	ftsk spoiiie
AOLE_15340	COG0492	ferredoxin-NADP+ reductase activity
AOLE_15345	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AOLE_15355	COG0456	acetyltransferase
AOLE_15375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AOLE_15380	COG0049	tRNA binding
AOLE_15385	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AOLE_15410	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AOLE_15410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOLE_15425	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_15430	COG4638	Rieske (2fe-2S)
AOLE_15445	COG0473	3-isopropylmalate dehydrogenase activity
AOLE_15450	COG0583	DNA-binding transcription factor activity
AOLE_15460	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AOLE_15495	COG0358	DNA primase activity
AOLE_15510	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AOLE_15520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AOLE_15550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AOLE_15560	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AOLE_15560	COG0352	thiamine-phosphate diphosphorylase activity
AOLE_15560	COG0351	phosphomethylpyrimidine kinase
AOLE_15565	COG1652	LysM domain
AOLE_15590	COG1399	metal-binding, possibly nucleic acid-binding protein
AOLE_15595	COG3101	peptidyl-lysine hydroxylation
AOLE_15600	COG0009	L-threonylcarbamoyladenylate synthase
AOLE_15605	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AOLE_15610	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AOLE_15625	COG4106	trans-aconitate 2-methyltransferase activity
AOLE_15640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOLE_15640	COG0596	Alpha beta hydrolase
AOLE_15640	COG2226	methyltransferase
AOLE_15650	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AOLE_15655	COG2223	nitrite transmembrane transporter activity
AOLE_15675	COG1196	nuclear chromosome segregation
AOLE_15685	COG0730	response to heat
AOLE_15700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AOLE_15710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOLE_15760	COG0489	protein tyrosine kinase activity
AOLE_15780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOLE_15780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOLE_15815	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AOLE_15820	COG2081	HI0933 family
AOLE_15830	COG0668	transmembrane transport
AOLE_15850	COG0583	DNA-binding transcription factor activity
AOLE_15870	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOLE_15875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AOLE_15905	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AOLE_15930	COG2199	diguanylate cyclase activity
AOLE_15940	COG2205	protein histidine kinase activity
AOLE_15945	COG0745	RESPONSE REGULATOR receiver
AOLE_15960	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOLE_15995	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AOLE_16000	COG0583	DNA-binding transcription factor activity
AOLE_16005	COG0384	phenazine biosynthesis protein PhzF
AOLE_16060	COG1309	transcriptional regulator
AOLE_16065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOLE_16070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AOLE_16080	COG0583	DNA-binding transcription factor activity
AOLE_16100	COG1473	amidohydrolase
AOLE_16110	COG0583	DNA-binding transcription factor activity
AOLE_16125	COG0583	DNA-binding transcription factor activity
AOLE_16130	COG1053	succinate dehydrogenase
AOLE_16145	COG1309	transcriptional regulator
AOLE_16155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOLE_16160	COG2814	Major facilitator Superfamily
AOLE_16165	COG1960	acyl-CoA dehydrogenase activity
AOLE_16170	COG0583	DNA-binding transcription factor activity
AOLE_16175	COG1063	alcohol dehydrogenase
AOLE_16185	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AOLE_16190	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AOLE_16195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AOLE_16215	COG2132	Multicopper oxidase
AOLE_16225	COG0561	phosphatase activity
AOLE_16230	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AOLE_16255	COG1214	PFAM Peptidase M22, glycoprotease
AOLE_16315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AOLE_16320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AOLE_16325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AOLE_16360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOLE_16370	COG1846	Transcriptional regulator
AOLE_16375	COG1764	response to oxidative stress
AOLE_16415	COG0037	tRNA processing
AOLE_16425	COG0248	Ppx GppA phosphatase
AOLE_16450	COG0072	phenylalanine-tRNA ligase activity
AOLE_16475	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AOLE_16480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AOLE_16490	COG1238	metal cluster binding
AOLE_16495	COG0625	glutathione transferase activity
AOLE_16500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AOLE_16510	COG0318	PFAM AMP-dependent synthetase and ligase
AOLE_16515	COG3028	Belongs to the UPF0307 family
AOLE_16520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOLE_16540	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AOLE_16545	COG0617	tRNA 3'-terminal CCA addition
AOLE_16550	COG1555	photosystem II stabilization
AOLE_16555	COG3956	TIGRFAM MazG family protein
AOLE_16560	COG4221	oxidoreductase activity
AOLE_16565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOLE_16580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AOLE_16585	COG0784	Response regulator, receiver
AOLE_16585	COG2205	protein histidine kinase activity
AOLE_16585	COG5002	protein histidine kinase activity
AOLE_16590	COG1024	Enoyl-CoA hydratase
AOLE_16595	COG2084	Dehydrogenase
AOLE_16600	COG3622	Belongs to the hyi family
AOLE_16615	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AOLE_16620	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AOLE_16625	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AOLE_16630	COG0697	spore germination
AOLE_16640	COG2814	Major facilitator Superfamily
AOLE_16645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOLE_16660	COG0583	DNA-binding transcription factor activity
AOLE_16665	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AOLE_16675	COG0084	hydrolase, TatD family'
AOLE_16690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AOLE_16715	COG0440	acetolactate synthase activity
AOLE_16720	COG0028	Belongs to the TPP enzyme family
AOLE_16745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOLE_16750	COG0577	efflux transmembrane transporter activity
AOLE_16750	COG1136	(ABC) transporter
AOLE_16770	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AOLE_16775	COG1162	GTPase activity
AOLE_16785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AOLE_16805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AOLE_16810	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_16850	COG2986	histidine ammonia-lyase
AOLE_16860	COG1216	Glycosyl transferase, family 2
AOLE_16865	COG0318	PFAM AMP-dependent synthetase and ligase
AOLE_16875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AOLE_16880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AOLE_16900	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOLE_16920	COG1426	Protein conserved in bacteria
AOLE_16940	COG2975	iron-sulfur cluster assembly
AOLE_16955	COG0793	Belongs to the peptidase S41A family
AOLE_16970	COG2267	carboxylic ester hydrolase activity
AOLE_16980	COG3265	gluconokinase activity
AOLE_16990	COG0800	Aldolase
AOLE_17000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AOLE_17005	COG0280	phosphate acetyltransferase
AOLE_17005	COG0857	belongs to the CobB CobQ family
AOLE_17010	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AOLE_17010	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AOLE_17030	COG0740	serine-type endopeptidase activity
AOLE_17040	COG4774	siderophore transport
AOLE_17050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AOLE_17060	COG2813	Specifically methylates the guanine in position
AOLE_17060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOLE_17170	COG0788	formyltetrahydrofolate deformylase activity
AOLE_17185	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AOLE_17190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AOLE_17195	COG4651	solute:proton antiporter activity
AOLE_17195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AOLE_17215	COG0724	RNA recognition motif
AOLE_17220	COG0210	DNA helicase
AOLE_17245	COG1733	regulation of RNA biosynthetic process
AOLE_17250	COG0604	alcohol dehydrogenase
AOLE_17255	COG2900	Belongs to the SlyX family
AOLE_17270	COG1560	Kdo2-lipid A biosynthetic process
AOLE_17280	COG1301	dicarboxylic acid transport
AOLE_17335	COG0473	3-isopropylmalate dehydrogenase activity
AOLE_17360	COG0583	DNA-binding transcription factor activity
AOLE_17400	COG0583	DNA-binding transcription factor activity
AOLE_17410	COG0625	glutathione transferase activity
AOLE_17415	COG2378	regulation of single-species biofilm formation
AOLE_17430	COG1530	ribonuclease E activity
AOLE_17440	COG0583	DNA-binding transcription factor activity
AOLE_17445	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_17450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AOLE_17460	COG0534	Mate efflux family protein
AOLE_17475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOLE_17500	COG0493	'glutamate synthase
AOLE_17510	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AOLE_17515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOLE_17530	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AOLE_17540	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AOLE_17540	COG0644	oxidoreductase
AOLE_17555	COG4535	Mg2 and Co2 transporter CorC
AOLE_17565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOLE_17590	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AOLE_17600	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AOLE_17610	COG0484	heat shock protein binding
AOLE_17615	COG0789	Transcriptional regulator
AOLE_17620	COG0598	Magnesium transport protein CorA
AOLE_17625	COG1185	polyribonucleotide nucleotidyltransferase activity
AOLE_17640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AOLE_17645	COG1074	ATP-dependent DNA helicase activity
AOLE_17650	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AOLE_17670	COG2226	methyltransferase
AOLE_17680	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOLE_17700	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AOLE_17715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AOLE_17715	COG2111	Na H antiporter
AOLE_17720	COG1006	Multisubunit Na H antiporter MnhC subunit
AOLE_17725	COG0651	ATP synthesis coupled electron transport
AOLE_17735	COG2212	antiporter activity
AOLE_17745	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AOLE_17755	COG0195	Participates in both transcription termination and antitermination
AOLE_17800	COG0237	dephospho-CoA kinase activity
AOLE_17810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOLE_17825	COG0497	DNA recombination
AOLE_17835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AOLE_17865	COG2169	Transcriptional regulator
AOLE_17865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AOLE_17870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AOLE_17935	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AOLE_17950	COG0326	Molecular chaperone. Has ATPase activity
AOLE_17965	COG2056	Na+-H+ antiporter family
AOLE_18005	COG0222	ribosome binding
AOLE_18010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AOLE_18045	COG0546	phosphoglycolate phosphatase activity
AOLE_18050	COG1716	ATPase activity
AOLE_18095	COG0181	hydroxymethylbilane synthase activity
AOLE_18105	COG3275	phosphorelay sensor kinase activity
AOLE_18125	COG1538	Outer membrane efflux protein
AOLE_18130	COG0697	spore germination
AOLE_18150	COG0494	nUDIX hydrolase
AOLE_18160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AOLE_18165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOLE_18170	COG0772	Belongs to the SEDS family
AOLE_18200	COG4974	Belongs to the 'phage' integrase family
AOLE_18205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOLE_18215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AOLE_18225	COG2197	response regulator
AOLE_18240	COG0793	Belongs to the peptidase S41A family
AOLE_18245	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AOLE_18250	COG0795	lipopolysaccharide-transporting ATPase activity
AOLE_18290	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOLE_18290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOLE_18305	COG0004	ammonium transporteR
AOLE_18310	COG0347	Belongs to the P(II) protein family
AOLE_18320	COG0606	chelatase, subunit chli
AOLE_18325	COG0431	NADPH-dependent FMN reductase
AOLE_18330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOLE_18335	COG0235	Class ii aldolase
AOLE_18340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOLE_18360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AOLE_18375	COG0318	PFAM AMP-dependent synthetase and ligase
AOLE_18385	COG0477	Major facilitator Superfamily
AOLE_18390	COG2860	membrane
AOLE_18400	COG1253	flavin adenine dinucleotide binding
AOLE_18410	COG2814	Major facilitator Superfamily
AOLE_18420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AOLE_18455	COG0655	NAD(P)H dehydrogenase (quinone) activity
AOLE_18470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AOLE_18480	COG1309	transcriptional regulator
AOLE_18520	COG0758	DNA mediated transformation
AOLE_18530	COG0697	spore germination
AOLE_18535	COG1309	transcriptional regulator
AOLE_18550	COG0386	Belongs to the glutathione peroxidase family
AOLE_18560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AOLE_18565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AOLE_18620	COG1121	(ABC) transporter
AOLE_18625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AOLE_18635	COG2837	iron assimilation
AOLE_18640	COG0281	malic enzyme
AOLE_18690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AOLE_18690	COG0519	Catalyzes the synthesis of GMP from XMP
AOLE_18695	COG4399	Belongs to the UPF0754 family
AOLE_18700	COG2259	Doxx family
AOLE_18705	COG0586	Pfam SNARE associated Golgi protein
AOLE_18720	COG1192	Involved in chromosome partitioning
AOLE_18730	COG0271	Belongs to the BolA IbaG family
AOLE_18755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AOLE_18765	COG1960	acyl-CoA dehydrogenase activity
AOLE_18770	COG0318	PFAM AMP-dependent synthetase and ligase
AOLE_18775	COG2197	response regulator
AOLE_18785	COG3916	Acyl-homoserine-lactone synthase
AOLE_18790	COG0477	Major facilitator Superfamily
AOLE_18795	COG1024	Enoyl-CoA hydratase
AOLE_18800	COG1024	Enoyl-CoA hydratase
AOLE_18805	COG1960	acyl-CoA dehydrogenase activity
AOLE_18810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOLE_18830	COG1113	amino acid transport
AOLE_18835	COG1113	amino acid transport
AOLE_18840	COG0251	oxidation-reduction process
AOLE_18855	COG1522	sequence-specific DNA binding
AOLE_18880	COG0564	pseudouridine synthase activity
AOLE_18995	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AOLE_19010	COG1802	Transcriptional regulator
AOLE_19015	COG1448	Aminotransferase
AOLE_19020	COG0277	FAD linked oxidase domain protein
AOLE_19030	COG2186	Transcriptional regulator
AOLE_19040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOLE_19050	COG2755	lipolytic protein G-D-S-L family
AOLE_19050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AOLE_19055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AOLE_19070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AOLE_19075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AOLE_19080	COG1216	Glycosyl transferase, family 2
AOLE_19095	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AOLE_19110	COG0438	transferase activity, transferring glycosyl groups
AOLE_19135	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AOLE_19165	COG0728	peptidoglycan biosynthetic process
AOLE_19170	COG3023	N-Acetylmuramoyl-L-alanine amidase
AOLE_19205	COG1017	nitric oxide dioxygenase activity
AOLE_19205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOLE_19230	COG0546	phosphoglycolate phosphatase activity
AOLE_19235	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_19250	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AOLE_19250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AOLE_19255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOLE_19260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOLE_19265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOLE_19270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOLE_19275	COG1116	anion transmembrane transporter activity
AOLE_19280	COG1309	transcriptional regulator
AOLE_19285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AOLE_19295	COG0196	riboflavin kinase activity
AOLE_19300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AOLE_19310	COG1047	Peptidyl-prolyl cis-trans
AOLE_19325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AOLE_19350	COG0583	DNA-binding transcription factor activity
AOLE_19380	COG2951	lytic endotransglycosylase activity
AOLE_19385	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AOLE_19400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AOLE_19410	COG0671	phosphoesterase, PA-phosphatase related
AOLE_19415	COG0861	Integral membrane protein TerC family
AOLE_19425	COG0402	S-adenosylhomocysteine deaminase activity
AOLE_19440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOLE_19445	COG1230	cation diffusion facilitator family transporter
AOLE_19460	COG0706	membrane insertase activity
AOLE_19475	COG0230	Belongs to the bacterial ribosomal protein bL34 family