ME3_87 4fa9cbe6a7942aebaec396d5d5fb033d 263 Gene3D G3DSA:3.40.50.300 1 242 6.9E-55 T 30-10-2018 ME3_87 4fa9cbe6a7942aebaec396d5d5fb033d 263 PRINTS PR00142 RecA protein signature 42 71 5.6E-40 T 30-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 ME3_87 4fa9cbe6a7942aebaec396d5d5fb033d 263 PRINTS PR00142 RecA protein signature 80 109 5.6E-40 T 30-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 ME3_87 4fa9cbe6a7942aebaec396d5d5fb033d 263 PRINTS PR00142 RecA protein signature 156 185 5.6E-40 T 30-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 ME3_87 4fa9cbe6a7942aebaec396d5d5fb033d 263 PRINTS PR00142 RecA protein signature 8 37 5.6E-40 T 30-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 ME3_87 4fa9cbe6a7942aebaec396d5d5fb033d 263 PRINTS PR00142 RecA protein signature 123 151 5.6E-40 T 30-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 ME3_87 4fa9cbe6a7942aebaec396d5d5fb033d 263 PRINTS PR00142 RecA protein signature 215 232 5.6E-40 T 30-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 ME3_87 4fa9cbe6a7942aebaec396d5d5fb033d 263 Pfam PF00154 recA bacterial DNA recombination protein 2 181 2.1E-47 T 30-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 ME3_87 4fa9cbe6a7942aebaec396d5d5fb033d 263 SUPERFAMILY SSF54752 183 242 4.45E-5 T 30-10-2018 IPR023400 DNA recombination and repair protein RecA, C-terminal ME3_87 4fa9cbe6a7942aebaec396d5d5fb033d 263 SUPERFAMILY SSF52540 2 180 4.72E-19 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase ME3_107 0c55fd915d3d032f7fb5d4c971d97512 79 SUPERFAMILY SSF55831 1 79 3.14E-19 T 30-10-2018 IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 ME3_107 0c55fd915d3d032f7fb5d4c971d97512 79 Pfam PF00303 Thymidylate synthase 1 79 4.6E-21 T 30-10-2018 IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 ME3_107 0c55fd915d3d032f7fb5d4c971d97512 79 Gene3D G3DSA:3.30.572.10 1 79 4.8E-21 T 30-10-2018 IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 ME3_77 39471b89e29c71127696b4b61791d15f 367 ProSitePatterns PS00333 ATP-dependent DNA ligase signature 2. 248 272 - T 30-10-2018 IPR016059 DNA ligase, ATP-dependent, conserved site GO:0003909|GO:0051103 ME3_77 39471b89e29c71127696b4b61791d15f 367 SUPERFAMILY SSF50249 246 354 1.63E-12 T 30-10-2018 IPR012340 Nucleic acid-binding, OB-fold ME3_77 39471b89e29c71127696b4b61791d15f 367 Gene3D G3DSA:3.30.1490.70 89 262 3.3E-14 T 30-10-2018 ME3_77 39471b89e29c71127696b4b61791d15f 367 ProSitePatterns PS00697 ATP-dependent DNA ligase AMP-binding site. 92 100 - T 30-10-2018 IPR016059 DNA ligase, ATP-dependent, conserved site GO:0003909|GO:0051103 ME3_77 39471b89e29c71127696b4b61791d15f 367 SUPERFAMILY SSF56091 61 272 2.64E-26 T 30-10-2018 ME3_77 39471b89e29c71127696b4b61791d15f 367 Gene3D G3DSA:3.30.470.30 97 223 3.3E-14 T 30-10-2018 ME3_77 39471b89e29c71127696b4b61791d15f 367 Pfam PF01068 ATP dependent DNA ligase domain 77 272 2.6E-15 T 30-10-2018 IPR012310 DNA ligase, ATP-dependent, central GO:0003910|GO:0005524|GO:0006281|GO:0006310 ME3_67 8530eedd14a23cf9737d51e13a6b9f98 687 PRINTS PR01183 Ribonucleotide reductase large chain signature 544 571 9.2E-14 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 ME3_67 8530eedd14a23cf9737d51e13a6b9f98 687 PRINTS PR01183 Ribonucleotide reductase large chain signature 472 495 9.2E-14 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 ME3_67 8530eedd14a23cf9737d51e13a6b9f98 687 PRINTS PR01183 Ribonucleotide reductase large chain signature 183 202 9.2E-14 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 ME3_67 8530eedd14a23cf9737d51e13a6b9f98 687 PRINTS PR01183 Ribonucleotide reductase large chain signature 444 466 9.2E-14 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 ME3_67 8530eedd14a23cf9737d51e13a6b9f98 687 PRINTS PR01183 Ribonucleotide reductase large chain signature 316 327 9.2E-14 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 ME3_67 8530eedd14a23cf9737d51e13a6b9f98 687 TIGRFAM TIGR02506 NrdE_NrdA: ribonucleoside-diphosphate reductase, alpha subunit 37 667 1.8E-110 T 30-10-2018 IPR013346 Ribonucleotide reductase, class I , alpha subunit GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 ME3_67 8530eedd14a23cf9737d51e13a6b9f98 687 SUPERFAMILY SSF51998 110 671 1.1E-98 T 30-10-2018 ME3_67 8530eedd14a23cf9737d51e13a6b9f98 687 Pfam PF02867 Ribonucleotide reductase, barrel domain 110 663 1.6E-65 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 ME3_67 8530eedd14a23cf9737d51e13a6b9f98 687 SUPERFAMILY SSF48168 10 106 1.57E-18 T 30-10-2018 IPR008926 Ribonucleotide reductase R1 subunit, N-terminal KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 ME3_67 8530eedd14a23cf9737d51e13a6b9f98 687 Pfam PF00317 Ribonucleotide reductase, all-alpha domain 31 105 8.5E-11 T 30-10-2018 IPR013509 Ribonucleotide reductase large subunit, N-terminal GO:0004748|GO:0005524|GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 ME3_233 38a19761c91007bb631c14a8d91636a6 137 SUPERFAMILY SSF89095 3 136 2.35E-10 T 30-10-2018 IPR003789 Aspartyl/glutamyl-tRNA amidotransferase subunit B-like GO:0016884 ME3_233 38a19761c91007bb631c14a8d91636a6 137 Pfam PF09424 Yqey-like protein 3 136 5.0E-9 T 30-10-2018 IPR019004 Uncharacterised protein YqeY/AIM41 ME3_298 f111131997bedcc0818ca4a4d228b1c8 256 Gene3D G3DSA:3.40.50.620 6 247 3.1E-41 T 30-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold ME3_298 f111131997bedcc0818ca4a4d228b1c8 256 Pfam PF02540 NAD synthase 11 243 9.4E-33 T 30-10-2018 IPR022310 NAD/GMP synthase ME3_298 f111131997bedcc0818ca4a4d228b1c8 256 SUPERFAMILY SSF52402 7 246 1.31E-35 T 30-10-2018 ME3_298 f111131997bedcc0818ca4a4d228b1c8 256 TIGRFAM TIGR00552 nadE: NAD+ synthetase 15 243 4.7E-33 T 30-10-2018 IPR003694 NAD(+) synthetase GO:0003952|GO:0005524|GO:0009435 KEGG: 00760+6.3.1.5|Reactome: R-HSA-196807 ME3_37 be7245b21d173a1ded32c5c0071aa236 2329 SUPERFAMILY SSF51261 1262 1402 1.62E-29 T 30-10-2018 IPR011055 Duplicated hybrid motif ME3_37 be7245b21d173a1ded32c5c0071aa236 2329 SUPERFAMILY SSF50199 1095 1242 1.96E-20 T 30-10-2018 ME3_37 be7245b21d173a1ded32c5c0071aa236 2329 Pfam PF01551 Peptidase family M23 1301 1401 2.6E-21 T 30-10-2018 IPR016047 Peptidase M23 ME3_37 be7245b21d173a1ded32c5c0071aa236 2329 Gene3D G3DSA:2.70.70.10 1272 1423 3.6E-28 T 30-10-2018 IPR011055 Duplicated hybrid motif ME3_37 be7245b21d173a1ded32c5c0071aa236 2329 Pfam PF00565 Staphylococcal nuclease homologue 1126 1241 6.0E-13 T 30-10-2018 IPR016071 Staphylococcal nuclease (SNase-like), OB-fold Reactome: R-HSA-6802952 ME3_37 be7245b21d173a1ded32c5c0071aa236 2329 SMART SM00318 1097 1242 8.2E-16 T 30-10-2018 IPR016071 Staphylococcal nuclease (SNase-like), OB-fold Reactome: R-HSA-6802952 ME3_37 be7245b21d173a1ded32c5c0071aa236 2329 Gene3D G3DSA:2.40.50.90 1096 1250 7.5E-23 T 30-10-2018 IPR035437 SNase-like, OB-fold superfamily ME3_305 7ace9cee1f260c770f8677b5b7baf39b 253 Pfam PF13759 Putative 2OG-Fe(II) oxygenase 163 244 7.3E-10 T 30-10-2018 IPR012668 Conserved hypothetical protein CHP02466 ME3_305 7ace9cee1f260c770f8677b5b7baf39b 253 SUPERFAMILY SSF51197 105 243 4.53E-5 T 30-10-2018 ME3_305 7ace9cee1f260c770f8677b5b7baf39b 253 Gene3D G3DSA:2.60.120.620 28 243 1.3E-11 T 30-10-2018 ME3_238 fbfbb2faeef1051169abfee44c381d56 229 SUPERFAMILY SSF57997 33 154 7.52E-5 T 30-10-2018 ME3_293 afc8ee3775fbcb55312bed5a62fdb522 229 Pfam PF10138 vWA found in TerF C terminus 32 218 1.6E-17 T 30-10-2018 IPR019303 vWA found in TerF C terminus ME3_293 afc8ee3775fbcb55312bed5a62fdb522 229 Gene3D G3DSA:3.40.50.410 11 221 9.4E-12 T 30-10-2018 IPR036465 von Willebrand factor A-like domain superfamily ME3_293 afc8ee3775fbcb55312bed5a62fdb522 229 SUPERFAMILY SSF53300 31 198 1.04E-10 T 30-10-2018 IPR036465 von Willebrand factor A-like domain superfamily ME3_108 88e83ddec47ae9e2a89168be8f9f7aea 241 SUPERFAMILY SSF55831 6 167 4.19E-38 T 30-10-2018 IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 ME3_108 88e83ddec47ae9e2a89168be8f9f7aea 241 PRINTS PR00108 Thymidylate synthase family signature 38 59 9.2E-8 T 30-10-2018 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 ME3_108 88e83ddec47ae9e2a89168be8f9f7aea 241 PRINTS PR00108 Thymidylate synthase family signature 114 133 9.2E-8 T 30-10-2018 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 ME3_108 88e83ddec47ae9e2a89168be8f9f7aea 241 Gene3D G3DSA:3.30.572.10 4 179 5.8E-40 T 30-10-2018 IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 ME3_108 88e83ddec47ae9e2a89168be8f9f7aea 241 Pfam PF00303 Thymidylate synthase 6 216 2.6E-37 T 30-10-2018 IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 ME3_214 590c4577d8e04bc92680c2305dc05608 146 SUPERFAMILY SSF55811 9 131 5.15E-20 T 30-10-2018 IPR015797 NUDIX hydrolase-like domain superfamily GO:0016787 ME3_214 590c4577d8e04bc92680c2305dc05608 146 ProSitePatterns PS00893 Nudix box signature. 38 59 - T 30-10-2018 IPR020084 NUDIX hydrolase, conserved site GO:0016787 ME3_214 590c4577d8e04bc92680c2305dc05608 146 Pfam PF00293 NUDIX domain 18 118 7.5E-13 T 30-10-2018 IPR000086 NUDIX hydrolase domain GO:0016787 ME3_214 590c4577d8e04bc92680c2305dc05608 146 Gene3D G3DSA:3.90.79.10 3 126 2.1E-17 T 30-10-2018 ME3_164 c5b42395ab35a17308cc69d8e9e1d560 176 Gene3D G3DSA:3.40.50.620 1 176 3.6E-34 T 30-10-2018 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold ME3_164 c5b42395ab35a17308cc69d8e9e1d560 176 Pfam PF01467 Cytidylyltransferase-like 8 110 3.3E-10 T 30-10-2018 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 ME3_164 c5b42395ab35a17308cc69d8e9e1d560 176 TIGRFAM TIGR00125 cyt_tran_rel: cytidyltransferase-like domain 6 66 3.1E-13 T 30-10-2018 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 ME3_164 c5b42395ab35a17308cc69d8e9e1d560 176 SUPERFAMILY SSF52374 4 172 2.41E-18 T 30-10-2018 ME3_130 34a2cccf7bb8e0089ce722bacf608548 350 SUPERFAMILY SSF69572 59 251 2.35E-16 T 30-10-2018 IPR035985 Ubiquitin-activating enzyme GO:0008641 ME3_130 34a2cccf7bb8e0089ce722bacf608548 350 Pfam PF00899 ThiF family 59 242 6.0E-18 T 30-10-2018 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 ME3_130 34a2cccf7bb8e0089ce722bacf608548 350 Gene3D G3DSA:3.40.50.720 59 306 8.6E-24 T 30-10-2018 ME3_61 f08925583c21d40e28eabb841b1dea86 931 SUPERFAMILY SSF56672 792 903 9.23E-19 T 30-10-2018 ME3_61 f08925583c21d40e28eabb841b1dea86 931 SUPERFAMILY SSF53098 8 178 2.13E-21 T 30-10-2018 IPR012337 Ribonuclease H-like superfamily ME3_61 f08925583c21d40e28eabb841b1dea86 931 SUPERFAMILY SSF56672 191 532 2.89E-17 T 30-10-2018 ME3_61 f08925583c21d40e28eabb841b1dea86 931 SMART SM00482 743 931 5.5E-4 T 30-10-2018 IPR001098 DNA-directed DNA polymerase, family A, palm domain GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 ME3_61 f08925583c21d40e28eabb841b1dea86 931 SUPERFAMILY SSF51294 551 767 3.77E-6 T 30-10-2018 IPR036844 Hint domain superfamily Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5632684|Reactome: R-HSA-5635838|Reactome: R-HSA-5658034 ME3_61 f08925583c21d40e28eabb841b1dea86 931 Pfam PF00476 DNA polymerase family A 793 902 2.6E-9 T 30-10-2018 IPR001098 DNA-directed DNA polymerase, family A, palm domain GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 ME3_61 f08925583c21d40e28eabb841b1dea86 931 Gene3D G3DSA:3.30.420.10 8 209 1.1E-33 T 30-10-2018 IPR036397 Ribonuclease H superfamily GO:0003676 ME3_61 f08925583c21d40e28eabb841b1dea86 931 Gene3D G3DSA:3.30.70.370 809 930 6.8E-16 T 30-10-2018 ME3_81 d496b77dd7b97a18869026d25fff3ae4 94 SMART SM00411 2 91 6.3E-20 T 30-10-2018 IPR000119 Histone-like DNA-binding protein GO:0003677 ME3_81 d496b77dd7b97a18869026d25fff3ae4 94 Gene3D G3DSA:4.10.520.10 1 93 5.5E-25 T 30-10-2018 IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily GO:0003677 ME3_81 d496b77dd7b97a18869026d25fff3ae4 94 SUPERFAMILY SSF47729 5 91 1.07E-21 T 30-10-2018 IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily GO:0003677 ME3_81 d496b77dd7b97a18869026d25fff3ae4 94 Pfam PF00216 Bacterial DNA-binding protein 5 91 1.3E-23 T 30-10-2018 IPR000119 Histone-like DNA-binding protein GO:0003677 ME3_81 d496b77dd7b97a18869026d25fff3ae4 94 PRINTS PR01727 Prokaryotic integration host factor signature 75 89 6.2E-9 T 30-10-2018 IPR000119 Histone-like DNA-binding protein GO:0003677 ME3_81 d496b77dd7b97a18869026d25fff3ae4 94 PRINTS PR01727 Prokaryotic integration host factor signature 59 72 6.2E-9 T 30-10-2018 IPR000119 Histone-like DNA-binding protein GO:0003677 ME3_81 d496b77dd7b97a18869026d25fff3ae4 94 PRINTS PR01727 Prokaryotic integration host factor signature 41 56 6.2E-9 T 30-10-2018 IPR000119 Histone-like DNA-binding protein GO:0003677 ME3_171 b9d00c0c411c53c9861684d6312b60c9 236 Pfam PF06941 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) 80 222 9.8E-8 T 30-10-2018 IPR010708 5'(3')-deoxyribonucleotidase GO:0008253|GO:0009264 Reactome: R-HSA-73621 ME3_171 b9d00c0c411c53c9861684d6312b60c9 236 SUPERFAMILY SSF56784 79 233 1.18E-12 T 30-10-2018 IPR036412 HAD-like superfamily ME3_10 c294c64cd64719164fce3fc1b3a8287c 150 Gene3D G3DSA:3.40.91.30 29 145 6.7E-7 T 30-10-2018 IPR011578 T7 endonuclease I-like GO:0003677|GO:0004536 ME3_10 c294c64cd64719164fce3fc1b3a8287c 150 Pfam PF08722 TnsA endonuclease N terminal 47 114 4.2E-6 T 30-10-2018 IPR014833 TnsA endonuclease, N-terminal ME3_9 7f6945f9941a83bd6db4a99d4c791ccc 431 Pfam PF14890 Intein splicing domain 142 219 5.4E-12 T 30-10-2018 ME3_9 7f6945f9941a83bd6db4a99d4c791ccc 431 SUPERFAMILY SSF51294 123 274 7.22E-27 T 30-10-2018 IPR036844 Hint domain superfamily Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5632684|Reactome: R-HSA-5635838|Reactome: R-HSA-5658034 ME3_9 7f6945f9941a83bd6db4a99d4c791ccc 431 SMART SM00306 121 225 9.7E-11 T 30-10-2018 IPR003587 Hint domain N-terminal Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5632684|Reactome: R-HSA-5635838|Reactome: R-HSA-5658034 ME3_9 7f6945f9941a83bd6db4a99d4c791ccc 431 Gene3D G3DSA:2.170.16.10 121 276 2.4E-30 T 30-10-2018 ME3_9 7f6945f9941a83bd6db4a99d4c791ccc 431 SMART SM00305 236 281 6.8E-8 T 30-10-2018 IPR003586 Hint domain C-terminal Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5632684|Reactome: R-HSA-5635838|Reactome: R-HSA-5658034 ME3_9 7f6945f9941a83bd6db4a99d4c791ccc 431 TIGRFAM TIGR01445 intein_Nterm: intein N-terminal splicing region 123 195 2.8E-9 T 30-10-2018 IPR006141 Intein N-terminal splicing region GO:0016539 Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5632684|Reactome: R-HSA-5635838|Reactome: R-HSA-5658034 ME3_9 7f6945f9941a83bd6db4a99d4c791ccc 431 TIGRFAM TIGR01443 intein_Cterm: intein C-terminal splicing region 254 276 5.0E-7 T 30-10-2018 IPR030934 Intein C-terminal splicing region ME3_287 c77a6f407a89f761d628f60aae454c12 239 Gene3D G3DSA:3.40.50.1000 1 139 2.2E-5 T 30-10-2018 IPR023214 HAD superfamily ME3_287 c77a6f407a89f761d628f60aae454c12 239 PIRSF PIRSF030802 1 237 5.9E-26 T 30-10-2018 IPR024197 Uncharacterised conserved protein UCP030802 ME3_287 c77a6f407a89f761d628f60aae454c12 239 SUPERFAMILY SSF56784 5 222 2.36E-6 T 30-10-2018 IPR036412 HAD-like superfamily ME3_104 f1cf2349eb89661bcdca34e15707ce0a 5419 Gene3D G3DSA:2.60.120.260 3432 3577 9.4E-12 T 30-10-2018 IPR008979 Galactose-binding-like domain superfamily ME3_104 f1cf2349eb89661bcdca34e15707ce0a 5419 Gene3D G3DSA:2.60.120.260 996 1134 1.0E-5 T 30-10-2018 IPR008979 Galactose-binding-like domain superfamily ME3_104 f1cf2349eb89661bcdca34e15707ce0a 5419 Gene3D G3DSA:2.60.120.260 5269 5400 4.3E-8 T 30-10-2018 IPR008979 Galactose-binding-like domain superfamily ME3_104 f1cf2349eb89661bcdca34e15707ce0a 5419 Gene3D G3DSA:2.60.120.260 5007 5130 4.6E-7 T 30-10-2018 IPR008979 Galactose-binding-like domain superfamily ME3_104 f1cf2349eb89661bcdca34e15707ce0a 5419 Pfam PF00754 F5/8 type C domain 4505 4608 1.8E-8 T 30-10-2018 IPR000421 Coagulation factor 5/8 C-terminal domain ME3_104 f1cf2349eb89661bcdca34e15707ce0a 5419 SUPERFAMILY SSF49785 5264 5397 4.59E-6 T 30-10-2018 IPR008979 Galactose-binding-like domain superfamily ME3_104 f1cf2349eb89661bcdca34e15707ce0a 5419 SUPERFAMILY SSF49785 4483 4622 6.8E-9 T 30-10-2018 IPR008979 Galactose-binding-like domain superfamily ME3_104 f1cf2349eb89661bcdca34e15707ce0a 5419 SUPERFAMILY SSF49785 3442 3571 5.95E-7 T 30-10-2018 IPR008979 Galactose-binding-like domain superfamily ME3_104 f1cf2349eb89661bcdca34e15707ce0a 5419 SUPERFAMILY SSF49785 4178 4331 1.89E-8 T 30-10-2018 IPR008979 Galactose-binding-like domain superfamily ME3_104 f1cf2349eb89661bcdca34e15707ce0a 5419 Pfam PF09327 Domain of unknown function (DUF1983) 4356 4413 3.0E-6 T 30-10-2018 IPR015406 Domain of unknown function DUF1983 ME3_104 f1cf2349eb89661bcdca34e15707ce0a 5419 Gene3D G3DSA:2.60.120.260 4179 4331 2.9E-11 T 30-10-2018 IPR008979 Galactose-binding-like domain superfamily ME3_104 f1cf2349eb89661bcdca34e15707ce0a 5419 Gene3D G3DSA:2.60.120.260 4469 4628 8.7E-14 T 30-10-2018 IPR008979 Galactose-binding-like domain superfamily ME3_58 20217f950f82d83384c23b9ef65422d8 369 SUPERFAMILY SSF56300 29 294 1.97E-24 T 30-10-2018 ME3_58 20217f950f82d83384c23b9ef65422d8 369 Pfam PF00149 Calcineurin-like phosphoesterase 30 228 9.7E-12 T 30-10-2018 IPR004843 Calcineurin-like phosphoesterase domain, ApaH type GO:0016787 ME3_58 20217f950f82d83384c23b9ef65422d8 369 Gene3D G3DSA:3.60.21.10 26 274 1.3E-29 T 30-10-2018 IPR029052 Metallo-dependent phosphatase-like ME3_123 016c86dbe35573ad7b93a5fe4cc99dfc 194 SUPERFAMILY SSF53254 1 183 1.16E-25 T 30-10-2018 IPR029033 Histidine phosphatase superfamily ME3_123 016c86dbe35573ad7b93a5fe4cc99dfc 194 SMART SM00855 2 164 5.7E-11 T 30-10-2018 IPR013078 Histidine phosphatase superfamily, clade-1 ME3_123 016c86dbe35573ad7b93a5fe4cc99dfc 194 Gene3D G3DSA:3.40.50.1240 1 194 1.3E-25 T 30-10-2018 IPR029033 Histidine phosphatase superfamily ME3_123 016c86dbe35573ad7b93a5fe4cc99dfc 194 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 4 188 5.6E-19 T 30-10-2018 IPR013078 Histidine phosphatase superfamily, clade-1 ME3_286 9a20a7601c1896f844991d1fd294ee81 355 Pfam PF15608 PELOTA RNA binding domain 279 355 2.6E-14 T 30-10-2018 IPR028157 PELOTA RNA-binding domain ME3_286 9a20a7601c1896f844991d1fd294ee81 355 Pfam PF11202 Phosphoribosyl transferase (PRTase) 5 251 5.9E-69 T 30-10-2018 IPR011215 Phosphoribosyl transferase ME3_261 857778d80913548f2c878fa9a6f71575 359 Pfam PF09414 RNA ligase 183 335 1.6E-17 T 30-10-2018 IPR021122 RNA ligase domain, REL/Rln2 ME3_261 857778d80913548f2c878fa9a6f71575 359 Gene3D G3DSA:3.30.470.30 171 325 3.3E-11 T 30-10-2018 ME3_261 857778d80913548f2c878fa9a6f71575 359 SUPERFAMILY SSF56091 152 358 2.13E-22 T 30-10-2018 ME3_215 db461f5817c8c0833e6255d0da97d3f9 366 SMART SM00382 75 198 0.0083 T 30-10-2018 IPR003593 AAA+ ATPase domain ME3_215 db461f5817c8c0833e6255d0da97d3f9 366 Pfam PF00910 RNA helicase 81 155 9.2E-5 T 30-10-2018 IPR000605 Helicase, superfamily 3, single-stranded DNA/RNA virus GO:0003723|GO:0003724 ME3_215 db461f5817c8c0833e6255d0da97d3f9 366 Gene3D G3DSA:3.40.50.300 34 180 6.4E-7 T 30-10-2018 ME3_215 db461f5817c8c0833e6255d0da97d3f9 366 SUPERFAMILY SSF52540 78 245 5.58E-13 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase ME3_236 df4be3996abca8ee74fd4fe594d51f5c 481 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 305 422 2.6E-13 T 30-10-2018 IPR003959 ATPase, AAA-type, core GO:0005524 ME3_236 df4be3996abca8ee74fd4fe594d51f5c 481 SMART SM00382 301 425 2.6E-5 T 30-10-2018 IPR003593 AAA+ ATPase domain ME3_236 df4be3996abca8ee74fd4fe594d51f5c 481 SUPERFAMILY SSF52540 281 423 1.34E-19 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase ME3_236 df4be3996abca8ee74fd4fe594d51f5c 481 Gene3D G3DSA:3.40.50.300 279 439 2.5E-18 T 30-10-2018 ME3_273 692e649453c73c412d565da68c876ceb 191 SUPERFAMILY SSF56784 16 176 5.17E-7 T 30-10-2018 IPR036412 HAD-like superfamily ME3_288 242482d3c3e478eace77fce4c401e210 375 SUPERFAMILY SSF53271 60 199 6.67E-9 T 30-10-2018 IPR029057 Phosphoribosyltransferase-like ME3_288 242482d3c3e478eace77fce4c401e210 375 PIRSF PIRSF020967 2 372 2.1E-51 T 30-10-2018 IPR011214 Uncharacterised conserved protein UCP020967 ME3_288 242482d3c3e478eace77fce4c401e210 375 Gene3D G3DSA:3.40.50.2020 58 226 2.1E-7 T 30-10-2018 ME3_288 242482d3c3e478eace77fce4c401e210 375 Pfam PF15609 Phosphoribosyl transferase 29 199 1.0E-43 T 30-10-2018 ME3_106 c0d3e16d8ccd9afe0c57b5be79eee063 574 Pfam PF07484 Phage Tail Collar Domain 430 488 1.1E-12 T 30-10-2018 IPR011083 Phage tail collar domain ME3_106 c0d3e16d8ccd9afe0c57b5be79eee063 574 SUPERFAMILY SSF88874 423 574 3.53E-34 T 30-10-2018 ME3_106 c0d3e16d8ccd9afe0c57b5be79eee063 574 Gene3D G3DSA:3.90.1340.10 425 490 7.6E-9 T 30-10-2018 IPR037053 Phage tail collar domain superfamily ME3_106 c0d3e16d8ccd9afe0c57b5be79eee063 574 Pfam PF03406 Phage tail fibre repeat 244 281 1.7E-7 T 30-10-2018 IPR005068 Bacteriophage lambda, Stf, side tail fibre-repeat-2 ME3_141 00a84ce843d3f9a94eba4d84d769eaf3 255 SUPERFAMILY SSF52540 12 199 6.11E-15 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase ME3_141 00a84ce843d3f9a94eba4d84d769eaf3 255 Pfam PF02562 PhoH-like protein 44 249 9.2E-42 T 30-10-2018 IPR003714 PhoH-like protein GO:0005524 ME3_141 00a84ce843d3f9a94eba4d84d769eaf3 255 Gene3D G3DSA:3.40.50.300 41 250 9.2E-43 T 30-10-2018 ME3_80 e228d0189e29a6588fb61e8b5eefa0cf 168 Gene3D G3DSA:1.10.3420.10 2 168 1.1E-19 T 30-10-2018 IPR023292 NTP pyrophosphohydrolase-like domain superfamily ME3_80 e228d0189e29a6588fb61e8b5eefa0cf 168 Pfam PF01503 Phosphoribosyl-ATP pyrophosphohydrolase 11 128 2.0E-7 T 30-10-2018 IPR021130 Phosphoribosyl-ATP pyrophosphohydrolase-like KEGG: 00340+3.6.1.31 ME3_119 f4c4ea315bfe8c814eae9116163ce1f6 415 Gene3D G3DSA:3.40.50.300 1 191 6.2E-35 T 30-10-2018 ME3_119 f4c4ea315bfe8c814eae9116163ce1f6 415 SUPERFAMILY SSF52540 3 176 3.31E-26 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase ME3_119 f4c4ea315bfe8c814eae9116163ce1f6 415 SUPERFAMILY SSF52540 126 396 2.92E-41 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase ME3_119 f4c4ea315bfe8c814eae9116163ce1f6 415 SMART SM00382 12 166 3.5E-7 T 30-10-2018 IPR003593 AAA+ ATPase domain ME3_119 f4c4ea315bfe8c814eae9116163ce1f6 415 Pfam PF05970 PIF1-like helicase 10 206 5.8E-38 T 30-10-2018 IPR010285 DNA helicase Pif1-like GO:0000723|GO:0003678|GO:0006281 ME3_119 f4c4ea315bfe8c814eae9116163ce1f6 415 Pfam PF05970 PIF1-like helicase 215 296 8.5E-7 T 30-10-2018 IPR010285 DNA helicase Pif1-like GO:0000723|GO:0003678|GO:0006281 ME3_22 c9e3c2378e905dbf3f4915670ace816b 398 SUPERFAMILY SSF56563 65 223 9.42E-5 T 30-10-2018 ME3_290 9bb3ec7c85af468d687c68d946792faf 203 Gene3D G3DSA:2.60.60.30 26 196 9.5E-48 T 30-10-2018 ME3_290 9bb3ec7c85af468d687c68d946792faf 203 Pfam PF02342 TerD domain 7 198 3.3E-37 T 30-10-2018 IPR003325 TerD domain ME3_62 5e29c49758a932836f67ac09a2e38d52 596 Gene3D G3DSA:3.40.1360.10 154 289 5.4E-26 T 30-10-2018 ME3_62 5e29c49758a932836f67ac09a2e38d52 596 Pfam PF13155 Toprim-like 176 268 6.7E-5 T 30-10-2018 ME3_62 5e29c49758a932836f67ac09a2e38d52 596 SUPERFAMILY SSF56731 96 281 8.11E-28 T 30-10-2018 ME3_62 5e29c49758a932836f67ac09a2e38d52 596 Gene3D G3DSA:3.40.50.300 306 570 1.2E-35 T 30-10-2018 ME3_62 5e29c49758a932836f67ac09a2e38d52 596 Pfam PF13481 AAA domain 333 495 9.4E-11 T 30-10-2018 ME3_62 5e29c49758a932836f67ac09a2e38d52 596 SUPERFAMILY SSF52540 319 551 1.16E-17 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase ME3_240 8f84f4aa3a72af935d6bd0bc3508369a 179 Gene3D G3DSA:3.40.430.10 1 178 6.0E-30 T 30-10-2018 IPR024072 Dihydrofolate reductase-like domain superfamily Reactome: R-HSA-196757 ME3_240 8f84f4aa3a72af935d6bd0bc3508369a 179 Pfam PF00186 Dihydrofolate reductase 1 173 2.2E-30 T 30-10-2018 IPR001796 Dihydrofolate reductase domain GO:0004146|GO:0046654|GO:0055114 KEGG: 00670+1.5.1.3|KEGG: 00790+1.5.1.3|MetaCyc: PWY-3841|MetaCyc: PWY-6614|Reactome: R-HSA-196757 ME3_240 8f84f4aa3a72af935d6bd0bc3508369a 179 SUPERFAMILY SSF53597 1 174 3.17E-31 T 30-10-2018 IPR024072 Dihydrofolate reductase-like domain superfamily Reactome: R-HSA-196757 ME3_240 8f84f4aa3a72af935d6bd0bc3508369a 179 ProSitePatterns PS00075 Dihydrofolate reductase (DHFR) domain signature. 13 35 - T 30-10-2018 IPR017925 Dihydrofolate reductase conserved site GO:0004146|GO:0055114 KEGG: 00670+1.5.1.3|KEGG: 00790+1.5.1.3|MetaCyc: PWY-3841|MetaCyc: PWY-6614|Reactome: R-HSA-1474151|Reactome: R-HSA-196757|Reactome: R-HSA-539107 ME3_240 8f84f4aa3a72af935d6bd0bc3508369a 179 PRINTS PR00070 Dihydrofolate reductase signature 40 51 3.2E-9 T 30-10-2018 ME3_240 8f84f4aa3a72af935d6bd0bc3508369a 179 PRINTS PR00070 Dihydrofolate reductase signature 108 122 3.2E-9 T 30-10-2018 ME3_240 8f84f4aa3a72af935d6bd0bc3508369a 179 PRINTS PR00070 Dihydrofolate reductase signature 27 35 3.2E-9 T 30-10-2018 ME3_240 8f84f4aa3a72af935d6bd0bc3508369a 179 PRINTS PR00070 Dihydrofolate reductase signature 13 23 3.2E-9 T 30-10-2018 ME3_13 5a732187962f95c49aad129bd4ff3751 760 SUPERFAMILY SSF51294 147 283 6.02E-26 T 30-10-2018 IPR036844 Hint domain superfamily Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5632684|Reactome: R-HSA-5635838|Reactome: R-HSA-5658034 ME3_13 5a732187962f95c49aad129bd4ff3751 760 TIGRFAM TIGR01443 intein_Cterm: intein C-terminal splicing region 263 284 5.9E-4 T 30-10-2018 IPR030934 Intein C-terminal splicing region ME3_13 5a732187962f95c49aad129bd4ff3751 760 SMART SM00305 244 289 5.9E-6 T 30-10-2018 IPR003586 Hint domain C-terminal Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5632684|Reactome: R-HSA-5635838|Reactome: R-HSA-5658034 ME3_13 5a732187962f95c49aad129bd4ff3751 760 Gene3D G3DSA:3.40.50.300 266 423 3.0E-21 T 30-10-2018 ME3_13 5a732187962f95c49aad129bd4ff3751 760 Gene3D G3DSA:2.170.16.20 142 242 5.3E-13 T 30-10-2018 ME3_13 5a732187962f95c49aad129bd4ff3751 760 SMART SM00306 145 243 1.6E-13 T 30-10-2018 IPR003587 Hint domain N-terminal Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5632684|Reactome: R-HSA-5635838|Reactome: R-HSA-5658034 ME3_13 5a732187962f95c49aad129bd4ff3751 760 SUPERFAMILY SSF52540 284 393 4.76E-7 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase ME3_13 5a732187962f95c49aad129bd4ff3751 760 Pfam PF14890 Intein splicing domain 154 237 2.1E-11 T 30-10-2018 ME3_13 5a732187962f95c49aad129bd4ff3751 760 TIGRFAM TIGR01445 intein_Nterm: intein N-terminal splicing region 147 218 3.0E-7 T 30-10-2018 IPR006141 Intein N-terminal splicing region GO:0016539 Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5632684|Reactome: R-HSA-5635838|Reactome: R-HSA-5658034 ME3_103 b455e99703d9b06a646a3a630a46fce6 1183 Gene3D G3DSA:2.60.120.260 787 939 1.7E-5 T 30-10-2018 IPR008979 Galactose-binding-like domain superfamily ME3_86 a98a9fc4c3ac66027921c47b80fc3913 235 ProSitePatterns PS00125 Serine/threonine specific protein phosphatases signature. 71 76 - T 30-10-2018 IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase GO:0016787 KEGG: 04658+3.1.3.16|KEGG: 04660+3.1.3.16 ME3_86 a98a9fc4c3ac66027921c47b80fc3913 235 Gene3D G3DSA:3.60.21.10 2 225 4.7E-52 T 30-10-2018 IPR029052 Metallo-dependent phosphatase-like ME3_86 a98a9fc4c3ac66027921c47b80fc3913 235 SUPERFAMILY SSF56300 12 225 2.06E-41 T 30-10-2018 ME3_86 a98a9fc4c3ac66027921c47b80fc3913 235 Pfam PF00149 Calcineurin-like phosphoesterase 17 179 1.1E-11 T 30-10-2018 IPR004843 Calcineurin-like phosphoesterase domain, ApaH type GO:0016787 ME3_88 94b35c33abbc9567271ac7e586744bc3 317 Pfam PF03852 DNA mismatch endonuclease Vsr 200 255 2.3E-5 T 30-10-2018 IPR004603 DNA mismatch endonuclease vsr GO:0004519|GO:0006298 ME3_88 94b35c33abbc9567271ac7e586744bc3 317 Gene3D G3DSA:3.40.960.10 199 317 3.5E-23 T 30-10-2018 ME3_88 94b35c33abbc9567271ac7e586744bc3 317 SUPERFAMILY SSF52980 199 310 3.0E-10 T 30-10-2018 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 ME3_147 2c5132c8f4019e6f35e46a1eb74019d3 124 Gene3D G3DSA:1.10.287.70 4 123 7.9E-26 T 30-10-2018 ME3_147 2c5132c8f4019e6f35e46a1eb74019d3 124 SUPERFAMILY SSF81324 8 97 1.83E-22 T 30-10-2018 ME3_147 2c5132c8f4019e6f35e46a1eb74019d3 124 Pfam PF07885 Ion channel 20 79 6.8E-14 T 30-10-2018 IPR013099 Potassium channel domain ME3_74 15a1bf41c55b979a4fe5c41b67550f5c 273 ProDom PD130832 RIIB EARLY PROTECTOR PROPHAGE-INDUCED MEMBRANE FROM LYSIS DNA-BINDING RIIA-RIIB DNA 57 252 3.0E-35 T 30-10-2018 ME3_85 9434bec768723921bf422ee0d6d6fd6c 298 Gene3D G3DSA:3.40.50.1010 30 164 1.0E-5 T 30-10-2018 ME3_85 9434bec768723921bf422ee0d6d6fd6c 298 SUPERFAMILY SSF88723 56 152 5.23E-5 T 30-10-2018 IPR029060 PIN-like domain superfamily ME3_113 95a8d42fed0e5310ad14d8f7fc0281dc 151 Pfam PF07486 Cell Wall Hydrolase 46 139 1.0E-13 T 30-10-2018 IPR011105 Cell wall hydrolase, SleB GO:0016787 ME3_113 95a8d42fed0e5310ad14d8f7fc0281dc 151 Gene3D G3DSA:1.10.10.2520 26 106 7.2E-13 T 30-10-2018 ME3_82 ef477e26dc083c610f3380b0ef30a3f7 227 Pfam PF16124 RecQ zinc-binding 169 209 8.3E-9 T 30-10-2018 IPR032284 ATP-dependent DNA helicase RecQ, zinc-binding domain ME3_82 ef477e26dc083c610f3380b0ef30a3f7 227 Pfam PF00271 Helicase conserved C-terminal domain 29 134 1.6E-16 T 30-10-2018 IPR001650 Helicase, C-terminal ME3_82 ef477e26dc083c610f3380b0ef30a3f7 227 Gene3D G3DSA:3.40.50.300 13 224 9.3E-51 T 30-10-2018 ME3_82 ef477e26dc083c610f3380b0ef30a3f7 227 SMART SM00490 54 135 2.5E-22 T 30-10-2018 IPR001650 Helicase, C-terminal ME3_82 ef477e26dc083c610f3380b0ef30a3f7 227 SUPERFAMILY SSF52540 12 214 1.56E-35 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase ME3_216 284854dafee11893b9c125327b7bf913 166 Pfam PF08719 Domain of unknown function (DUF1768) 18 162 2.7E-37 T 30-10-2018 IPR012816 NADAR ME3_216 284854dafee11893b9c125327b7bf913 166 Gene3D G3DSA:1.10.357.40 7 165 3.2E-34 T 30-10-2018 IPR037238 YbiA-like superfamily ME3_216 284854dafee11893b9c125327b7bf913 166 TIGRFAM TIGR02464 ribofla_fusion: conserved hypothetical protein 18 161 1.5E-39 T 30-10-2018 IPR012816 NADAR ME3_216 284854dafee11893b9c125327b7bf913 166 SUPERFAMILY SSF143990 3 163 1.44E-37 T 30-10-2018 IPR037238 YbiA-like superfamily ME3_66 806ad8beca82e054167232dc6a4fa198 368 SUPERFAMILY SSF47240 24 356 4.16E-40 T 30-10-2018 IPR009078 Ferritin-like superfamily ME3_66 806ad8beca82e054167232dc6a4fa198 368 Gene3D G3DSA:1.10.620.20 4 333 3.7E-66 T 30-10-2018 IPR012348 Ribonucleotide reductase-like GO:0016491|GO:0055114 Reactome: R-HSA-499943 ME3_66 806ad8beca82e054167232dc6a4fa198 368 Pfam PF00268 Ribonucleotide reductase, small chain 34 306 5.4E-16 T 30-10-2018 IPR000358 Ribonucleotide reductase small subunit family GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 ME3_243 0797a299ffa8d39489482c8e3b24c3c5 70 Pfam PF11792 Baculoviridae late expression factor 5 C-terminal domain 27 61 1.9E-5 T 30-10-2018 IPR021758 Baculoviridae late expression factor 5, C-terminal ME3_112 1a254da33e4987f7ad693ef6d66f0ddf 258 Gene3D G3DSA:3.60.20.10 1 178 4.9E-5 T 30-10-2018 IPR029055 Nucleophile aminohydrolases, N-terminal ME3_232 9f25029c3e4abe8960fbf5dac5887565 106 Pfam PF00085 Thioredoxin 7 102 4.9E-16 T 30-10-2018 IPR013766 Thioredoxin domain GO:0045454 ME3_232 9f25029c3e4abe8960fbf5dac5887565 106 Gene3D G3DSA:3.40.30.10 1 104 5.2E-18 T 30-10-2018 ME3_232 9f25029c3e4abe8960fbf5dac5887565 106 SUPERFAMILY SSF52833 2 103 8.56E-19 T 30-10-2018 IPR036249 Thioredoxin-like superfamily ME3_232 9f25029c3e4abe8960fbf5dac5887565 106 ProSitePatterns PS00194 Thioredoxin family active site. 24 42 - T 30-10-2018 IPR017937 Thioredoxin, conserved site GO:0045454 ME3_213 95f9abf33cde25294b15b50fd3bab4e0 481 SUPERFAMILY SSF53300 274 453 1.33E-9 T 30-10-2018 IPR036465 von Willebrand factor A-like domain superfamily ME3_213 95f9abf33cde25294b15b50fd3bab4e0 481 Pfam PF11443 Domain of unknown function (DUF2828) 158 455 4.8E-55 T 30-10-2018 IPR024553 Domain of unknown function DUF2828 ME3_213 95f9abf33cde25294b15b50fd3bab4e0 481 Pfam PF11443 Domain of unknown function (DUF2828) 11 115 1.2E-8 T 30-10-2018 IPR024553 Domain of unknown function DUF2828 ME3_203 fd5ad433af48b238ebba67edbc7ee063 220 Pfam PF01743 Poly A polymerase head domain 30 155 2.2E-30 T 30-10-2018 IPR002646 Poly A polymerase, head domain GO:0003723|GO:0006396|GO:0016779 Reactome: R-HSA-6784531|Reactome: R-HSA-6785470 ME3_203 fd5ad433af48b238ebba67edbc7ee063 220 Gene3D G3DSA:1.10.3090.10 156 219 1.7E-18 T 30-10-2018 ME3_203 fd5ad433af48b238ebba67edbc7ee063 220 SUPERFAMILY SSF81891 153 215 1.29E-20 T 30-10-2018 ME3_203 fd5ad433af48b238ebba67edbc7ee063 220 Gene3D G3DSA:3.30.460.10 13 155 7.0E-36 T 30-10-2018 ME3_203 fd5ad433af48b238ebba67edbc7ee063 220 Pfam PF12627 Probable RNA and SrmB- binding site of polymerase A 182 215 5.2E-5 T 30-10-2018 IPR032828 tRNA nucleotidyltransferase/poly(A) polymerase, RNA and SrmB- binding domain Reactome: R-HSA-6784531|Reactome: R-HSA-6785470 ME3_203 fd5ad433af48b238ebba67edbc7ee063 220 SUPERFAMILY SSF81301 15 152 6.76E-30 T 30-10-2018 ME3_7 088d066c960a5c3d28a41ced1a85142b 237 Pfam PF11860 N-acetylmuramidase 63 237 8.5E-38 T 30-10-2018 IPR024408 N-acetylmuramidase ME3_19 68168aa8b73dc9e15d4e8307535eb498 530 Pfam PF04860 Phage portal protein 109 341 9.1E-9 T 30-10-2018 IPR006944 Bacteriophage/Gene transfer agent portal protein ME3_295 e1f42e2e4a88f568d12d9b642b1198a9 198 SUPERFAMILY SSF56024 95 155 2.51E-6 T 30-10-2018 ME3_295 e1f42e2e4a88f568d12d9b642b1198a9 198 Gene3D G3DSA:3.30.870.10 6 146 2.0E-5 T 30-10-2018 ME3_57 a0a56a0caebc133c04def01b7a38aa00 625 SUPERFAMILY SSF52540 6 611 3.8E-24 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase ME3_57 a0a56a0caebc133c04def01b7a38aa00 625 Gene3D G3DSA:3.40.50.300 317 622 2.6E-13 T 30-10-2018 ME3_57 a0a56a0caebc133c04def01b7a38aa00 625 Gene3D G3DSA:3.40.50.300 5 298 5.0E-27 T 30-10-2018 ME3_2 dfcb58bf2a1fa3b5a7bdb0a5749b3d3b 217 Pfam PF05265 Protein of unknown function (DUF723) 87 139 8.5E-5 T 30-10-2018 IPR007929 Protein of unknown function DUF723 ME3_68 f0bbb39204700a62e77fdec4081de9ac 160 Gene3D G3DSA:3.40.960.10 9 119 1.3E-10 T 30-10-2018 ME3_68 f0bbb39204700a62e77fdec4081de9ac 160 SUPERFAMILY SSF52980 29 111 5.9E-5 T 30-10-2018 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 ME3_125 7cb358ff5e3d47549feae71cefe43570 287 SUPERFAMILY SSF64182 25 272 1.67E-14 T 30-10-2018 IPR038763 DHH phosphoesterase superfamily ME3_127 47beff12824cd6b727601ede1c3a547f 248 SUPERFAMILY SSF56300 1 241 2.17E-21 T 30-10-2018 ME3_127 47beff12824cd6b727601ede1c3a547f 248 Gene3D G3DSA:3.60.21.10 1 225 2.0E-14 T 30-10-2018 IPR029052 Metallo-dependent phosphatase-like ME3_127 47beff12824cd6b727601ede1c3a547f 248 Pfam PF00149 Calcineurin-like phosphoesterase 5 206 1.2E-10 T 30-10-2018 IPR004843 Calcineurin-like phosphoesterase domain, ApaH type GO:0016787 ME3_296 6275829f8a80b384084c1e54ed54b376 208 Gene3D G3DSA:3.40.220.10 55 208 1.7E-26 T 30-10-2018 ME3_296 6275829f8a80b384084c1e54ed54b376 208 SUPERFAMILY SSF52949 57 206 1.45E-20 T 30-10-2018 ME3_111 db33490d0681d820c901119519bfda5e 120 Pfam PF00692 dUTPase 27 114 3.1E-5 T 30-10-2018 IPR029054 dUTPase-like ME3_111 db33490d0681d820c901119519bfda5e 120 SUPERFAMILY SSF51283 14 115 1.31E-13 T 30-10-2018 IPR036157 dUTPase-like superfamily ME3_111 db33490d0681d820c901119519bfda5e 120 Gene3D G3DSA:2.70.40.10 12 119 1.7E-12 T 30-10-2018 IPR036157 dUTPase-like superfamily ME3_75 9fce7c4633c1d038f0aa9aea8835f5fe 779 SUPERFAMILY SSF55874 30 155 2.15E-17 T 30-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily ME3_75 9fce7c4633c1d038f0aa9aea8835f5fe 779 Gene3D G3DSA:3.30.565.10 8 223 4.9E-16 T 30-10-2018 IPR036890 Histidine kinase/HSP90-like ATPase superfamily ME3_101 e2e283c06ee1a038e2f16bb260bdfece 183 Pfam PF14301 Domain of unknown function (DUF4376) 85 179 8.5E-17 T 30-10-2018 IPR025484 Domain of unknown function DUF4376 ME3_205 761ef01da986bab6a1d0404cbfd77c78 108 Pfam PF10544 T5orf172 domain 4 80 1.7E-9 T 30-10-2018 IPR018306 Bacteriophage T5, Orf172 DNA-binding ME3_8 c5df2747a4d55b3caa97eeeab953d974 152 Pfam PF00959 Phage lysozyme 40 132 1.3E-10 T 30-10-2018 IPR002196 Glycoside hydrolase, family 24 GO:0003796|GO:0009253|GO:0016998 ME3_8 c5df2747a4d55b3caa97eeeab953d974 152 SUPERFAMILY SSF53955 9 147 3.58E-21 T 30-10-2018 IPR023346 Lysozyme-like domain superfamily ME3_8 c5df2747a4d55b3caa97eeeab953d974 152 Gene3D G3DSA:1.10.530.40 3 151 8.0E-26 T 30-10-2018 ME3_292 c1ed01b1ca9fc90ceb6561b0d3ebcf9e 370 Pfam PF04332 Protein of unknown function (DUF475) 57 359 8.1E-96 T 30-10-2018 IPR007427 Protein of unknown function DUF475 ME3_116 62e98f44bb38df62e6328644e9536ee9 57 Pfam PF04324 BFD-like [2Fe-2S] binding domain 2 45 2.1E-8 T 30-10-2018 IPR007419 BFD-like [2Fe-2S]-binding domain ME3_116 62e98f44bb38df62e6328644e9536ee9 57 Gene3D G3DSA:1.10.10.1100 1 55 2.4E-11 T 30-10-2018 ME3_230 904520a9b22feb8ca1966be86d2ad3cb 159 SUPERFAMILY SSF56300 8 124 6.12E-10 T 30-10-2018 ME3_230 904520a9b22feb8ca1966be86d2ad3cb 159 Pfam PF00149 Calcineurin-like phosphoesterase 5 123 6.3E-6 T 30-10-2018 IPR004843 Calcineurin-like phosphoesterase domain, ApaH type GO:0016787 ME3_230 904520a9b22feb8ca1966be86d2ad3cb 159 Gene3D G3DSA:3.60.21.10 3 155 1.8E-20 T 30-10-2018 IPR029052 Metallo-dependent phosphatase-like ME3_102 0acc8f779f6ef01d17eda9790dd9c25c 181 Pfam PF14301 Domain of unknown function (DUF4376) 83 177 1.3E-14 T 30-10-2018 IPR025484 Domain of unknown function DUF4376 ME3_302 12ba20342356bbe410ce5f17414b5bfc 130 Pfam PF11750 Protein of unknown function (DUF3307) 10 121 1.9E-10 T 30-10-2018 IPR021737 Bacteriophage phiKZ, Orf197 ME3_128 52c672df6d72cfe5bb5408745aa40f3e 549 Pfam PF14284 PcfJ-like protein 403 515 1.2E-17 T 30-10-2018 IPR025586 PcfJ-like protein