locus-tag	class	description
DKE42_000010	COG0592	DNA-directed DNA polymerase activity
DKE42_000065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DKE42_000070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DKE42_000105	COG0625	glutathione transferase activity
DKE42_000115	COG0733	neurotransmitter:sodium symporter activity
DKE42_000155	COG2233	PERMEase
DKE42_000205	COG2814	Major facilitator Superfamily
DKE42_000210	COG0656	L-ascorbic acid biosynthetic process
DKE42_000230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE42_000240	COG2818	Glycosylase
DKE42_000255	COG1194	a g-specific adenine glycosylase
DKE42_000270	COG5487	UPF0391 membrane protein
DKE42_000275	COG2983	Belongs to the UPF0260 family
DKE42_000280	COG2133	pyrroloquinoline quinone binding
DKE42_000285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DKE42_000290	COG2116	formate transmembrane transporter activity
DKE42_000310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE42_000315	COG1335	isochorismatase
DKE42_000320	COG0385	Bile acid
DKE42_000325	COG0534	Mate efflux family protein
DKE42_000360	COG1113	amino acid transport
DKE42_000380	COG2188	Transcriptional regulator
DKE42_000420	COG0546	phosphoglycolate phosphatase activity
DKE42_000430	COG1280	lysine exporter protein (LysE YggA)
DKE42_000455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DKE42_000470	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DKE42_000575	COG0534	Mate efflux family protein
DKE42_000655	COG3150	esterase
DKE42_000665	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DKE42_000685	COG2233	PERMEase
DKE42_000690	COG2351	hydroxyisourate hydrolase activity
DKE42_000740	COG1393	Belongs to the ArsC family
DKE42_000745	COG0708	Exodeoxyribonuclease III
DKE42_000785	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DKE42_000810	COG4942	peptidase
DKE42_000830	COG2119	membrane
DKE42_000840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE42_000840	COG0426	domain, Protein
DKE42_000910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DKE42_000920	COG1522	sequence-specific DNA binding
DKE42_000950	COG3162	membrane
DKE42_000955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKE42_000985	COG1309	transcriptional regulator
DKE42_001005	COG0352	thiamine-phosphate diphosphorylase activity
DKE42_001005	COG0351	phosphomethylpyrimidine kinase
DKE42_001005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DKE42_001050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DKE42_001055	COG1012	belongs to the aldehyde dehydrogenase family
DKE42_001065	COG1335	isochorismatase
DKE42_001110	COG0583	DNA-binding transcription factor activity
DKE42_001165	COG1733	regulation of RNA biosynthetic process
DKE42_001255	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DKE42_001270	COG2329	Antibiotic biosynthesis monooxygenase
DKE42_001290	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DKE42_001300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DKE42_001345	COG0745	RESPONSE REGULATOR receiver
DKE42_001360	COG4221	oxidoreductase activity
DKE42_001505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DKE42_001510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DKE42_001575	COG0069	glutamate synthase activity
DKE42_001575	COG0067	glutamate synthase
DKE42_001575	COG0070	glutamate synthase
DKE42_001590	COG1704	LemA family
DKE42_001655	COG0194	GDP metabolic process
DKE42_001705	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DKE42_001715	COG0335	large ribosomal subunit rRNA binding
DKE42_001730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DKE42_001760	COG0277	FAD linked oxidase domain protein
DKE42_001780	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DKE42_001815	COG1192	Involved in chromosome partitioning
DKE42_001850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DKE42_001855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE42_001910	COG0583	DNA-binding transcription factor activity
DKE42_001965	COG1983	PspC domain protein
DKE42_001990	COG0408	coproporphyrinogen oxidase activity
DKE42_002025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DKE42_002045	COG0598	Magnesium transport protein CorA
DKE42_002055	COG0494	nUDIX hydrolase
DKE42_002085	COG1946	Acyl-CoA thioesterase
DKE42_002105	COG1959	2 iron, 2 sulfur cluster binding
DKE42_002110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKE42_002110	COG1017	nitric oxide dioxygenase activity
DKE42_002140	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DKE42_002145	COG0088	Forms part of the polypeptide exit tunnel
DKE42_002245	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DKE42_002255	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DKE42_002315	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DKE42_002460	COG1183	phosphatidylcholine synthase activity
DKE42_002510	COG1309	transcriptional regulator
DKE42_002530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DKE42_002535	COG1960	acyl-CoA dehydrogenase activity
DKE42_002575	COG2969	positive regulation of protein catabolic process
DKE42_002585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DKE42_002595	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DKE42_002600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DKE42_002605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DKE42_002610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DKE42_002615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DKE42_002650	COG1408	metallophosphoesterase
DKE42_002660	COG2199	diguanylate cyclase activity
DKE42_002730	COG1607	acyl-coa hydrolase
DKE42_002765	COG2350	Protein conserved in bacteria
DKE42_002790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DKE42_002795	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DKE42_002805	COG1862	Preprotein translocase
DKE42_002845	COG0726	polysaccharide deacetylase
DKE42_002910	COG0625	glutathione transferase activity
DKE42_002915	COG0583	DNA-binding transcription factor activity
DKE42_002970	COG2096	Adenosyltransferase
DKE42_002985	COG0133	tryptophan synthase activity
DKE42_003075	COG2153	protein acetylation
DKE42_003105	COG2207	Transcriptional regulator
DKE42_003125	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DKE42_003155	COG2885	chlorophyll binding
DKE42_003155	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DKE42_003205	COG2094	Belongs to the DNA glycosylase MPG family
DKE42_003215	COG1902	pentaerythritol trinitrate reductase activity
DKE42_003260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE42_003275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE42_003290	COG3189	MarR family transcriptional regulator
DKE42_003295	COG2824	Alkylphosphonate utilization operon protein PhnA
DKE42_003300	COG3422	double-strand break repair
DKE42_003360	COG5510	response to toxic substance
DKE42_003370	COG2832	Protein of unknown function (DUF454)
DKE42_003425	COG1289	transmembrane transporter activity
DKE42_003430	COG2814	Major facilitator Superfamily
DKE42_003450	COG1115	amino acid carrier protein
DKE42_003460	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DKE42_003495	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DKE42_003505	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DKE42_003510	COG1077	Cell shape determining protein MreB Mrl
DKE42_003515	COG1792	Involved in formation and maintenance of cell shape
DKE42_003525	COG0424	maF-like protein
DKE42_003530	COG1530	ribonuclease E activity
DKE42_003540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DKE42_003585	COG2207	Transcriptional regulator
DKE42_003615	COG3046	protein related to deoxyribodipyrimidine photolyase
DKE42_003655	COG1752	Esterase of the alpha-beta hydrolase superfamily
DKE42_003685	COG0745	RESPONSE REGULATOR receiver
DKE42_003690	COG0642	Histidine kinase
DKE42_003705	COG0004	ammonium transporteR
DKE42_003710	COG0583	DNA-binding transcription factor activity
DKE42_003745	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_003755	COG0393	Putative heavy-metal-binding
DKE42_003765	COG1538	Outer membrane efflux protein
DKE42_003810	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DKE42_003830	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DKE42_003880	COG0321	lipoyl(octanoyl) transferase activity
DKE42_003885	COG2921	Belongs to the UPF0250 family
DKE42_003925	COG2009	succinate dehydrogenase
DKE42_003935	COG1053	succinate dehydrogenase
DKE42_003940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DKE42_004030	COG0589	response to stress
DKE42_004060	COG0505	Belongs to the CarA family
DKE42_004090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DKE42_004150	COG0477	Major facilitator Superfamily
DKE42_004155	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DKE42_004305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE42_004340	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DKE42_004375	COG1113	amino acid transport
DKE42_004460	COG4591	ABC-type transport system involved in lipoprotein release permease component
DKE42_004465	COG1136	(ABC) transporter
DKE42_004480	COG0616	signal peptide processing
DKE42_004480	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DKE42_004485	COG0596	Alpha beta hydrolase
DKE42_004490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DKE42_004555	COG0823	Involved in the tonB-independent uptake of proteins
DKE42_004575	COG0824	Thioesterase
DKE42_004610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DKE42_004620	COG1056	cytidyltransferase-related domain
DKE42_004620	COG1051	belongs to the nudix hydrolase family
DKE42_004635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DKE42_004650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DKE42_004665	COG4625	pathogenesis
DKE42_004705	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DKE42_004740	COG0481	GTPase activity
DKE42_004775	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DKE42_004785	COG4221	oxidoreductase activity
DKE42_004835	COG0556	nucleotide-excision repair
DKE42_004905	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DKE42_004945	COG1252	NADH dehydrogenase
DKE42_004985	COG0583	DNA-binding transcription factor activity
DKE42_005030	COG0352	thiamine-phosphate diphosphorylase activity
DKE42_005085	COG0076	glutamate decarboxylase activity
DKE42_005095	COG1522	sequence-specific DNA binding
DKE42_005110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DKE42_005165	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DKE42_005170	COG1686	Belongs to the peptidase S11 family
DKE42_005245	COG1966	Carbon starvation protein
DKE42_005250	COG2879	small protein
DKE42_005295	COG1741	Belongs to the pirin family
DKE42_005325	COG4604	ABC transporter, ATP-binding protein
DKE42_005335	COG4774	siderophore transport
DKE42_005355	COG3433	isochorismatase activity
DKE42_005355	COG1535	isochorismatase
DKE42_005390	COG1169	isochorismate synthase
DKE42_005430	COG0302	gtp cyclohydrolase
DKE42_005485	COG0512	Glutamine amidotransferase of anthranilate synthase
DKE42_005785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DKE42_005820	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DKE42_005845	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE42_005850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE42_005870	COG0024	Methionine aminopeptidase
DKE42_005935	COG0842	Transport permease protein
DKE42_005945	COG0582	viral genome integration into host DNA
DKE42_006235	COG4215	(ABC) transporter
DKE42_006255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKE42_006270	COG0384	phenazine biosynthesis protein PhzF
DKE42_006325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DKE42_006330	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DKE42_006335	COG3139	Protein of unknown function (DUF1315)
DKE42_006405	COG1690	Belongs to the RtcB family
DKE42_006410	COG1234	tRNA 3'-trailer cleavage
DKE42_006460	COG1278	Cold shock
DKE42_006465	COG0513	Belongs to the DEAD box helicase family
DKE42_006475	COG0778	Nitroreductase
DKE42_006535	COG1610	YqeY-like protein
DKE42_006540	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DKE42_006590	COG1278	Cold shock
DKE42_006610	COG0786	glutamate:sodium symporter activity
DKE42_006620	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_006695	COG2995	paraquat-inducible protein a
DKE42_006770	COG0745	RESPONSE REGULATOR receiver
DKE42_006815	COG1301	dicarboxylic acid transport
DKE42_006830	COG2011	ABC-type metal ion transport system permease component
DKE42_006895	COG1305	Transglutaminase-like
DKE42_006905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DKE42_006910	COG0305	Participates in initiation and elongation during chromosome replication
DKE42_006935	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DKE42_006940	COG1845	cytochrome c oxidase, subunit III
DKE42_006945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DKE42_006985	COG3658	cytochrome
DKE42_007025	COG2890	protein-(glutamine-N5) methyltransferase activity
DKE42_007030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE42_007050	COG1960	acyl-CoA dehydrogenase activity
DKE42_007055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE42_007070	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DKE42_007100	COG0745	RESPONSE REGULATOR receiver
DKE42_007165	COG2814	Major facilitator Superfamily
DKE42_007175	COG0583	DNA-binding transcription factor activity
DKE42_007210	COG0802	atpase or kinase
DKE42_007225	COG1923	regulation of RNA biosynthetic process
DKE42_007255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DKE42_007260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKE42_007260	COG0519	Catalyzes the synthesis of GMP from XMP
DKE42_007265	COG4302	ethanolamine ammonia-lyase activity
DKE42_007300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DKE42_007365	COG1605	Chorismate mutase
DKE42_007450	COG1733	regulation of RNA biosynthetic process
DKE42_007515	COG0589	response to stress
DKE42_007570	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_007640	COG1335	isochorismatase
DKE42_007690	COG0069	glutamate synthase activity
DKE42_007725	COG2814	Major facilitator Superfamily
DKE42_007740	COG0511	ligase activity, forming carbon-carbon bonds
DKE42_007870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE42_007900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DKE42_007975	COG2204	response regulator
DKE42_008010	COG0575	Belongs to the CDS family
DKE42_008045	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKE42_008075	COG1011	Hydrolase
DKE42_008090	COG1522	sequence-specific DNA binding
DKE42_008160	COG1105	Belongs to the carbohydrate kinase PfkB family
DKE42_008185	COG3193	protein, possibly involved in utilization of glycolate and propanediol
DKE42_008210	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DKE42_008215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE42_008270	COG4890	Cyd operon protein YbgT
DKE42_008275	COG1294	oxidase, subunit
DKE42_008290	COG1585	Membrane protein implicated in regulation of membrane protease activity
DKE42_008300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DKE42_008320	COG0569	domain protein
DKE42_008355	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DKE42_008370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DKE42_008460	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DKE42_008470	COG0183	Belongs to the thiolase family
DKE42_008475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DKE42_008480	COG0596	Alpha beta hydrolase
DKE42_008485	COG2271	Major facilitator Superfamily
DKE42_008490	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DKE42_008500	COG3485	protocatechuate 3,4-dioxygenase
DKE42_008510	COG3420	alginic acid biosynthetic process
DKE42_008530	COG2391	methyltransferase activity
DKE42_008545	COG1414	Transcriptional regulator
DKE42_008655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKE42_008665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DKE42_008670	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DKE42_008680	COG4829	muconolactone delta-isomerase
DKE42_008700	COG2186	Transcriptional regulator
DKE42_008720	COG1012	belongs to the aldehyde dehydrogenase family
DKE42_008725	COG2351	hydroxyisourate hydrolase activity
DKE42_008730	COG2233	PERMEase
DKE42_008745	COG2186	Transcriptional regulator
DKE42_008770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE42_008830	COG1309	transcriptional regulator
DKE42_008835	COG0583	DNA-binding transcription factor activity
DKE42_008840	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_008845	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_008850	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_008870	COG0318	PFAM AMP-dependent synthetase and ligase
DKE42_008975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DKE42_008980	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DKE42_009075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DKE42_009180	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DKE42_009190	COG4628	conserved protein (DUF2132)
DKE42_009245	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DKE42_009285	COG2205	protein histidine kinase activity
DKE42_009290	COG0745	RESPONSE REGULATOR receiver
DKE42_009355	COG3433	isochorismatase activity
DKE42_009355	COG1535	isochorismatase
DKE42_009360	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_009370	COG4149	molybdate abc transporter
DKE42_009375	COG0725	ABC transporter, periplasmic molybdate-binding protein
DKE42_009390	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DKE42_009395	COG0543	2 iron, 2 sulfur cluster binding
DKE42_009395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKE42_009410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE42_009440	COG2207	Transcriptional regulator
DKE42_009445	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_009450	COG2610	gluconate transmembrane transporter activity
DKE42_009490	COG0583	DNA-binding transcription factor activity
DKE42_009515	COG0583	DNA-binding transcription factor activity
DKE42_009580	COG0730	response to heat
DKE42_009610	COG1063	alcohol dehydrogenase
DKE42_009625	COG0508	dehydrogenase complex catalyzes the overall conversion of
DKE42_009635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DKE42_009640	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE42_009715	COG0583	DNA-binding transcription factor activity
DKE42_009720	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DKE42_009820	COG0730	response to heat
DKE42_009895	COG1960	acyl-CoA dehydrogenase activity
DKE42_009905	COG2207	Transcriptional regulator
DKE42_009915	COG0776	regulation of translation
DKE42_009940	COG0822	iron-sulfur transferase activity
DKE42_010040	COG0601	transmembrane transport
DKE42_010100	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DKE42_010120	COG2431	L-lysine efflux transmembrane transporter activity
DKE42_010135	COG0776	regulation of translation
DKE42_010200	COG0084	hydrolase, TatD family'
DKE42_010220	COG1663	tetraacyldisaccharide 4'-kinase activity
DKE42_010240	COG1475	DNA binding
DKE42_010310	COG0640	Transcriptional regulator
DKE42_010325	COG3122	Protein conserved in bacteria
DKE42_010355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DKE42_010360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKE42_010375	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DKE42_010390	COG3698	Phosphodiester glycosidase
DKE42_010410	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DKE42_010480	COG3539	Fimbrial protein
DKE42_010540	COG0583	DNA-binding transcription factor activity
DKE42_010570	COG1522	sequence-specific DNA binding
DKE42_010580	COG1126	abc transporter atp-binding protein
DKE42_010590	COG0765	amino acid transport
DKE42_010620	COG1464	Belongs to the NlpA lipoprotein family
DKE42_010630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DKE42_010640	COG0012	GTP binding
DKE42_010700	COG2207	Transcriptional regulator
DKE42_010700	COG1917	Cupin 2, conserved barrel domain protein
DKE42_010720	COG1301	dicarboxylic acid transport
DKE42_010770	COG0583	DNA-binding transcription factor activity
DKE42_010775	COG0431	NADPH-dependent FMN reductase
DKE42_010790	COG0640	Transcriptional regulator
DKE42_010840	COG2175	clavaminate synthase activity
DKE42_010845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE42_010890	COG1294	oxidase, subunit
DKE42_010945	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DKE42_010970	COG1346	cytolysis
DKE42_011030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DKE42_011035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DKE42_011070	COG0765	amino acid transport
DKE42_011075	COG0765	amino acid transport
DKE42_011120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DKE42_011140	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_011225	COG1960	acyl-CoA dehydrogenase activity
DKE42_011250	COG0583	DNA-binding transcription factor activity
DKE42_011290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DKE42_011340	COG1024	Enoyl-CoA hydratase
DKE42_011355	COG1960	acyl-CoA dehydrogenase activity
DKE42_011370	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DKE42_011420	COG0583	DNA-binding transcription factor activity
DKE42_011465	COG2050	protein possibly involved in aromatic compounds catabolism
DKE42_011475	COG3327	negative regulation of DNA-templated transcription, initiation
DKE42_011485	COG0183	Belongs to the thiolase family
DKE42_011510	COG2151	metal-sulfur cluster biosynthetic enzyme
DKE42_011520	COG3460	Phenylacetate-CoA oxygenase
DKE42_011525	COG3396	Phenylacetate-CoA oxygenase
DKE42_011555	COG0789	Transcriptional regulator
DKE42_011590	COG0590	tRNA wobble adenosine to inosine editing
DKE42_011595	COG0666	response to abiotic stimulus
DKE42_011600	COG0583	DNA-binding transcription factor activity
DKE42_011680	COG0038	chloride channel
DKE42_011685	COG4770	biotin carboxylase activity
DKE42_011730	COG3220	belongs to the UPF0276 family
DKE42_011820	COG1051	belongs to the nudix hydrolase family
DKE42_011880	COG3038	cytochrome b561
DKE42_011890	COG1733	regulation of RNA biosynthetic process
DKE42_011925	COG0531	amino acid
DKE42_011960	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DKE42_011970	COG4122	O-methyltransferase activity
DKE42_012000	COG1538	Outer membrane efflux protein
DKE42_012005	COG1137	ATPase activity
DKE42_012010	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DKE42_012020	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DKE42_012060	COG1733	regulation of RNA biosynthetic process
DKE42_012075	COG0668	transmembrane transport
DKE42_012135	COG2226	methyltransferase
DKE42_012160	COG1560	Kdo2-lipid A biosynthetic process
DKE42_012165	COG1280	lysine exporter protein (LysE YggA)
DKE42_012305	COG4638	Rieske (2fe-2S)
DKE42_012310	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DKE42_012320	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_012350	COG1643	Atp-dependent helicase
DKE42_012355	COG0450	alkyl hydroperoxide reductase
DKE42_012375	COG3634	alkyl hydroperoxide reductase activity
DKE42_012395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DKE42_012415	COG0625	glutathione transferase activity
DKE42_012475	COG1765	OsmC-like protein
DKE42_012490	COG0667	Aldo Keto reductase
DKE42_012505	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DKE42_012585	COG1598	PFAM Uncharacterised protein family UPF0150
DKE42_012915	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DKE42_013060	COG2186	Transcriptional regulator
DKE42_013220	COG4269	membrane
DKE42_013265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DKE42_013290	COG4172	Belongs to the ABC transporter superfamily
DKE42_013295	COG4239	(ABC) transporter, permease
DKE42_013355	COG0583	DNA-binding transcription factor activity
DKE42_013360	COG1279	arginine transmembrane transporter activity
DKE42_013380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKE42_013455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DKE42_013465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DKE42_013495	COG0742	ribosomal rna small subunit methyltransferase
DKE42_013520	COG0804	urea catabolic process
DKE42_013545	COG3015	lipoprotein NlpE involved in copper resistance
DKE42_013615	COG1773	rubredoxin
DKE42_013625	COG2267	carboxylic ester hydrolase activity
DKE42_013630	COG0583	DNA-binding transcription factor activity
DKE42_013665	COG4181	ATPase activity
DKE42_013730	COG0306	phosphate transporter
DKE42_013770	COG2223	nitrite transmembrane transporter activity
DKE42_013775	COG2207	Transcriptional regulator
DKE42_013780	COG2066	Belongs to the glutaminase family
DKE42_013815	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_013820	COG2267	carboxylic ester hydrolase activity
DKE42_013835	COG0446	pyridine nucleotide-disulphide oxidoreductase
DKE42_013845	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_013870	COG1414	Transcriptional regulator
DKE42_013895	COG1215	transferase activity, transferring glycosyl groups
DKE42_013920	COG0523	cobalamin synthesis protein
DKE42_013930	COG1607	acyl-coa hydrolase
DKE42_014195	COG0735	belongs to the Fur family
DKE42_014225	COG0121	glutamine amidotransferase
DKE42_014255	COG2885	chlorophyll binding
DKE42_014275	COG2894	cell division
DKE42_014300	COG0492	ferredoxin-NADP+ reductase activity
DKE42_014315	COG0456	acetyltransferase
DKE42_014330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DKE42_014345	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DKE42_014390	COG1012	belongs to the aldehyde dehydrogenase family
DKE42_014435	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKE42_014585	COG1399	metal-binding, possibly nucleic acid-binding protein
DKE42_014590	COG3101	peptidyl-lysine hydroxylation
DKE42_014595	COG0009	L-threonylcarbamoyladenylate synthase
DKE42_014635	COG0596	Alpha beta hydrolase
DKE42_014635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKE42_014635	COG2226	methyltransferase
DKE42_014645	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DKE42_014650	COG2223	nitrite transmembrane transporter activity
DKE42_014705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE42_014755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DKE42_014845	COG0583	DNA-binding transcription factor activity
DKE42_014865	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DKE42_014870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DKE42_014900	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DKE42_014940	COG0745	RESPONSE REGULATOR receiver
DKE42_015060	COG0789	Transcriptional regulator
DKE42_015140	COG0110	maltose O-acetyltransferase activity
DKE42_015215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE42_015220	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DKE42_015230	COG0583	DNA-binding transcription factor activity
DKE42_015285	COG0583	DNA-binding transcription factor activity
DKE42_015305	COG0583	DNA-binding transcription factor activity
DKE42_015395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DKE42_015430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DKE42_015450	COG1214	PFAM Peptidase M22, glycoprotease
DKE42_015510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DKE42_015515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DKE42_015580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DKE42_015595	COG1764	response to oxidative stress
DKE42_015690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DKE42_015695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DKE42_015715	COG0625	glutathione transferase activity
DKE42_015740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE42_015770	COG1555	photosystem II stabilization
DKE42_015780	COG4221	oxidoreductase activity
DKE42_015805	COG2205	protein histidine kinase activity
DKE42_015805	COG5002	protein histidine kinase activity
DKE42_015805	COG0784	Response regulator, receiver
DKE42_015810	COG1024	Enoyl-CoA hydratase
DKE42_015835	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DKE42_015840	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DKE42_015845	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DKE42_015895	COG2072	flavoprotein involved in K transport
DKE42_015900	COG0492	ferredoxin-NADP+ reductase activity
DKE42_015920	COG0640	Transcriptional regulator
DKE42_016080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE42_016115	COG0084	hydrolase, TatD family'
DKE42_016150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DKE42_016155	COG0440	acetolactate synthase activity
DKE42_016160	COG0028	Belongs to the TPP enzyme family
DKE42_016180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE42_016220	COG1162	GTPase activity
DKE42_016230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DKE42_016250	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DKE42_016270	COG1426	Protein conserved in bacteria
DKE42_016305	COG0793	Belongs to the peptidase S41A family
DKE42_016335	COG3265	gluconokinase activity
DKE42_016345	COG0800	Aldolase
DKE42_016370	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DKE42_016370	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DKE42_016390	COG0740	serine-type endopeptidase activity
DKE42_016420	COG2813	Specifically methylates the guanine in position
DKE42_016420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKE42_016520	COG0788	formyltetrahydrofolate deformylase activity
DKE42_016535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DKE42_016545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DKE42_016545	COG4651	solute:proton antiporter activity
DKE42_016565	COG0724	RNA recognition motif
DKE42_016595	COG1733	regulation of RNA biosynthetic process
DKE42_016600	COG0604	alcohol dehydrogenase
DKE42_016605	COG2900	Belongs to the SlyX family
DKE42_016620	COG1560	Kdo2-lipid A biosynthetic process
DKE42_016685	COG0473	3-isopropylmalate dehydrogenase activity
DKE42_016710	COG0583	DNA-binding transcription factor activity
DKE42_016765	COG0625	glutathione transferase activity
DKE42_016770	COG2378	regulation of single-species biofilm formation
DKE42_016775	COG0546	phosphoglycolate phosphatase activity
DKE42_016805	COG0583	DNA-binding transcription factor activity
DKE42_016815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DKE42_016865	COG0493	'glutamate synthase
DKE42_016875	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DKE42_016880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE42_016895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DKE42_016905	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
DKE42_016905	COG0644	oxidoreductase
DKE42_016920	COG4535	Mg2 and Co2 transporter CorC
DKE42_016930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DKE42_016960	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DKE42_016975	COG0789	Transcriptional regulator
DKE42_016980	COG0598	Magnesium transport protein CorA
DKE42_017000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DKE42_017030	COG2226	methyltransferase
DKE42_017045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKE42_017080	COG1006	Multisubunit Na H antiporter MnhC subunit
DKE42_017095	COG2212	antiporter activity
DKE42_017105	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DKE42_017165	COG0237	dephospho-CoA kinase activity
DKE42_017175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DKE42_017190	COG0497	DNA recombination
DKE42_017235	COG2169	Transcriptional regulator
DKE42_017235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DKE42_017240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DKE42_017325	COG0326	Molecular chaperone. Has ATPase activity
DKE42_017340	COG2056	Na+-H+ antiporter family
DKE42_017445	COG1716	ATPase activity
DKE42_017490	COG0181	hydroxymethylbilane synthase activity
DKE42_017555	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DKE42_017560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DKE42_017565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DKE42_017570	COG0772	Belongs to the SEDS family
DKE42_017595	COG4974	Belongs to the 'phage' integrase family
DKE42_017600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DKE42_017610	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DKE42_017635	COG0793	Belongs to the peptidase S41A family
DKE42_017640	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DKE42_017695	COG0004	ammonium transporteR
DKE42_017710	COG0606	chelatase, subunit chli
DKE42_017715	COG0431	NADPH-dependent FMN reductase
DKE42_017725	COG0235	Class ii aldolase
DKE42_017730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE42_017750	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DKE42_017775	COG0477	Major facilitator Superfamily
DKE42_017780	COG2860	membrane
DKE42_017790	COG1253	flavin adenine dinucleotide binding
DKE42_017800	COG2814	Major facilitator Superfamily
DKE42_017845	COG0655	NAD(P)H dehydrogenase (quinone) activity
DKE42_017890	COG1309	transcriptional regulator
DKE42_017935	COG0697	spore germination
DKE42_017970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DKE42_018020	COG1121	(ABC) transporter
DKE42_018025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DKE42_018030	COG1280	lysine exporter protein (LysE YggA)
DKE42_018040	COG0281	malic enzyme
DKE42_018090	COG0519	Catalyzes the synthesis of GMP from XMP
DKE42_018090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKE42_018100	COG2259	Doxx family
DKE42_018105	COG0586	Pfam SNARE associated Golgi protein
DKE42_018130	COG0271	Belongs to the BolA IbaG family
DKE42_018180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKE42_018180	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DKE42_018180	COG3321	synthase
DKE42_018180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DKE42_018205	COG3916	Acyl-homoserine-lactone synthase
DKE42_018210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE42_018225	COG1113	amino acid transport
DKE42_018230	COG0697	spore germination
DKE42_018250	COG1960	acyl-CoA dehydrogenase activity
DKE42_018280	COG1113	amino acid transport
DKE42_018285	COG0251	oxidation-reduction process
DKE42_018300	COG1522	sequence-specific DNA binding
DKE42_018325	COG0564	pseudouridine synthase activity
DKE42_018375	COG2801	Transposase and inactivated derivatives
DKE42_018425	COG1802	Transcriptional regulator
DKE42_018435	COG1448	Aminotransferase
DKE42_018485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DKE42_018490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DKE42_018515	COG2244	polysaccharide biosynthetic process
DKE42_018530	COG1091	dTDP-4-dehydrorhamnose reductase activity
DKE42_018575	COG3023	N-Acetylmuramoyl-L-alanine amidase
DKE42_018630	COG0546	phosphoglycolate phosphatase activity
DKE42_018635	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_018680	COG1309	transcriptional regulator
DKE42_018710	COG1047	Peptidyl-prolyl cis-trans
DKE42_018755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DKE42_018830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DKE42_018845	COG0861	Integral membrane protein TerC family
DKE42_018870	COG0402	S-adenosylhomocysteine deaminase activity
DKE42_018890	COG1230	cation diffusion facilitator family transporter
DKE42_018920	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DKE42_018955	COG0604	alcohol dehydrogenase
DKE42_018955	COG3321	synthase
DKE42_019000	COG2801	Transposase and inactivated derivatives
DKE42_019025	COG3077	Addiction module antitoxin, RelB DinJ family
DKE42_019040	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
DKE42_019060	COG2801	Transposase and inactivated derivatives
DKE42_019325	COG1475	DNA binding
DKE42_019330	COG1192	Involved in chromosome partitioning
DKE42_019360	COG0604	alcohol dehydrogenase
DKE42_019365	COG0604	alcohol dehydrogenase
DKE42_019455	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DKE42_019595	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DKE42_019610	COG2801	Transposase and inactivated derivatives
DKE42_019735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair