locus-tag	class	description
DKE45_000010	COG0592	DNA-directed DNA polymerase activity
DKE45_000065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DKE45_000070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DKE45_000105	COG0625	glutathione transferase activity
DKE45_000155	COG2233	PERMEase
DKE45_000205	COG2814	Major facilitator Superfamily
DKE45_000270	COG5487	UPF0391 membrane protein
DKE45_000275	COG2983	Belongs to the UPF0260 family
DKE45_000280	COG2133	pyrroloquinoline quinone binding
DKE45_000290	COG2116	formate transmembrane transporter activity
DKE45_000310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE45_000315	COG1335	isochorismatase
DKE45_000325	COG0534	Mate efflux family protein
DKE45_000330	COG1683	Conserved Protein
DKE45_000370	COG0523	cobalamin synthesis protein
DKE45_000380	COG2826	transposase and inactivated derivatives, IS30 family
DKE45_000465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DKE45_000475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DKE45_000590	COG0436	Aminotransferase
DKE45_000595	COG2733	membrane
DKE45_000665	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DKE45_000685	COG2233	PERMEase
DKE45_000690	COG2351	hydroxyisourate hydrolase activity
DKE45_000725	COG3706	GGDEF domain
DKE45_000745	COG0708	Exodeoxyribonuclease III
DKE45_000810	COG4942	peptidase
DKE45_000840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE45_000840	COG0426	domain, Protein
DKE45_000860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DKE45_000880	COG1902	pentaerythritol trinitrate reductase activity
DKE45_000915	COG1522	sequence-specific DNA binding
DKE45_000945	COG3162	membrane
DKE45_000995	COG1309	transcriptional regulator
DKE45_001025	COG0351	phosphomethylpyrimidine kinase
DKE45_001025	COG0352	thiamine-phosphate diphosphorylase activity
DKE45_001025	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DKE45_001060	COG1113	amino acid transport
DKE45_001085	COG1335	isochorismatase
DKE45_001130	COG0583	DNA-binding transcription factor activity
DKE45_001150	COG0667	Aldo Keto reductase
DKE45_001160	COG2801	Transposase and inactivated derivatives
DKE45_001175	COG1309	transcriptional regulator
DKE45_001200	COG1733	regulation of RNA biosynthetic process
DKE45_001245	COG3177	Filamentation induced by cAMP protein fic
DKE45_001290	COG2801	Transposase and inactivated derivatives
DKE45_001445	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DKE45_001460	COG2329	Antibiotic biosynthesis monooxygenase
DKE45_001485	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DKE45_001495	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DKE45_001540	COG0745	RESPONSE REGULATOR receiver
DKE45_001555	COG4221	oxidoreductase activity
DKE45_001695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DKE45_001765	COG0067	glutamate synthase
DKE45_001765	COG0069	glutamate synthase activity
DKE45_001765	COG0070	glutamate synthase
DKE45_001780	COG1704	LemA family
DKE45_001840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DKE45_001855	COG0194	GDP metabolic process
DKE45_001905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DKE45_001915	COG0335	large ribosomal subunit rRNA binding
DKE45_001970	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DKE45_001975	COG2249	NAD(P)H dehydrogenase (quinone) activity
DKE45_002000	COG0628	permease
DKE45_002005	COG1192	Involved in chromosome partitioning
DKE45_002045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE45_002095	COG0583	DNA-binding transcription factor activity
DKE45_002145	COG0517	IMP dehydrogenase activity
DKE45_002150	COG1983	PspC domain protein
DKE45_002160	COG2826	transposase and inactivated derivatives, IS30 family
DKE45_002170	COG1960	acyl-CoA dehydrogenase activity
DKE45_002220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DKE45_002240	COG0598	Magnesium transport protein CorA
DKE45_002250	COG0494	nUDIX hydrolase
DKE45_002255	COG1040	competence protein
DKE45_002275	COG2937	Belongs to the GPAT DAPAT family
DKE45_002280	COG1946	Acyl-CoA thioesterase
DKE45_002300	COG1959	2 iron, 2 sulfur cluster binding
DKE45_002315	COG0433	COG0433 Predicted ATPase
DKE45_002335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DKE45_002340	COG0088	Forms part of the polypeptide exit tunnel
DKE45_002440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DKE45_002450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DKE45_002480	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DKE45_002510	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DKE45_002570	COG0179	Fumarylacetoacetate (FAA) hydrolase
DKE45_002655	COG1183	phosphatidylcholine synthase activity
DKE45_002705	COG1309	transcriptional regulator
DKE45_002730	COG1960	acyl-CoA dehydrogenase activity
DKE45_002765	COG2826	transposase and inactivated derivatives, IS30 family
DKE45_002775	COG2969	positive regulation of protein catabolic process
DKE45_002785	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DKE45_002795	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DKE45_002825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DKE45_002835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKE45_002840	COG1408	metallophosphoesterase
DKE45_002845	COG2885	chlorophyll binding
DKE45_002845	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DKE45_002850	COG2199	diguanylate cyclase activity
DKE45_002905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE45_002905	COG3453	Protein conserved in bacteria
DKE45_002920	COG1607	acyl-coa hydrolase
DKE45_002955	COG2350	Protein conserved in bacteria
DKE45_002970	COG3781	membrane
DKE45_002980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DKE45_002985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DKE45_002995	COG1862	Preprotein translocase
DKE45_003115	COG0625	glutathione transferase activity
DKE45_003120	COG0583	DNA-binding transcription factor activity
DKE45_003130	COG1960	acyl-CoA dehydrogenase activity
DKE45_003225	COG0285	dihydrofolate synthase activity
DKE45_003275	COG2153	protein acetylation
DKE45_003300	COG2207	Transcriptional regulator
DKE45_003320	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DKE45_003350	COG2885	chlorophyll binding
DKE45_003350	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DKE45_003400	COG2094	Belongs to the DNA glycosylase MPG family
DKE45_003455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE45_003470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE45_003485	COG3189	MarR family transcriptional regulator
DKE45_003490	COG2824	Alkylphosphonate utilization operon protein PhnA
DKE45_003495	COG3422	double-strand break repair
DKE45_003555	COG5510	response to toxic substance
DKE45_003565	COG2832	Protein of unknown function (DUF454)
DKE45_003570	COG1376	ErfK ybiS ycfS ynhG family protein
DKE45_003645	COG1115	amino acid carrier protein
DKE45_003660	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
DKE45_003700	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DKE45_003710	COG1792	Involved in formation and maintenance of cell shape
DKE45_003715	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DKE45_003720	COG0424	maF-like protein
DKE45_003725	COG1530	ribonuclease E activity
DKE45_003755	COG2249	NAD(P)H dehydrogenase (quinone) activity
DKE45_003830	COG0142	geranyltranstransferase activity
DKE45_003850	COG1752	Esterase of the alpha-beta hydrolase superfamily
DKE45_003875	COG2194	sulfuric ester hydrolase activity
DKE45_003880	COG0745	RESPONSE REGULATOR receiver
DKE45_003885	COG0642	Histidine kinase
DKE45_003955	COG0393	Putative heavy-metal-binding
DKE45_004020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DKE45_004060	COG0531	amino acid
DKE45_004080	COG2921	Belongs to the UPF0250 family
DKE45_004120	COG2009	succinate dehydrogenase
DKE45_004130	COG1053	succinate dehydrogenase
DKE45_004135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DKE45_004255	COG0589	response to stress
DKE45_004285	COG0505	Belongs to the CarA family
DKE45_004365	COG2264	protein methyltransferase activity
DKE45_004375	COG0477	Major facilitator Superfamily
DKE45_004470	COG2801	Transposase and inactivated derivatives
DKE45_004545	COG2814	Major facilitator Superfamily
DKE45_004590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE45_004615	COG0741	lytic transglycosylase activity
DKE45_004640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DKE45_004670	COG2801	Transposase and inactivated derivatives
DKE45_004695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE45_004725	COG0243	molybdopterin cofactor binding
DKE45_004735	COG3339	Conserved Protein
DKE45_004760	COG1115	amino acid carrier protein
DKE45_004855	COG1136	(ABC) transporter
DKE45_004880	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DKE45_004880	COG0616	signal peptide processing
DKE45_004890	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DKE45_004955	COG0823	Involved in the tonB-independent uptake of proteins
DKE45_004975	COG0824	Thioesterase
DKE45_005005	COG2814	Major facilitator Superfamily
DKE45_005010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DKE45_005015	COG1024	Enoyl-CoA hydratase
DKE45_005020	COG1056	cytidyltransferase-related domain
DKE45_005020	COG1051	belongs to the nudix hydrolase family
DKE45_005050	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DKE45_005065	COG4625	pathogenesis
DKE45_005075	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DKE45_005085	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DKE45_005140	COG0681	Belongs to the peptidase S26 family
DKE45_005150	COG0571	ribonuclease III activity
DKE45_005170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DKE45_005230	COG0556	nucleotide-excision repair
DKE45_005300	COG2070	2-Nitropropane dioxygenase
DKE45_005315	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DKE45_005450	COG0352	thiamine-phosphate diphosphorylase activity
DKE45_005515	COG1522	sequence-specific DNA binding
DKE45_005530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DKE45_005550	COG0616	signal peptide processing
DKE45_005595	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DKE45_005600	COG1686	Belongs to the peptidase S11 family
DKE45_005670	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DKE45_005715	COG2801	Transposase and inactivated derivatives
DKE45_005735	COG1741	Belongs to the pirin family
DKE45_005755	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKE45_005760	COG4605	iron ion homeostasis
DKE45_005765	COG4604	ABC transporter, ATP-binding protein
DKE45_005770	COG4607	ABC-type enterochelin transport system periplasmic component
DKE45_005800	COG1132	(ABC) transporter
DKE45_005810	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DKE45_005860	COG0302	gtp cyclohydrolase
DKE45_005915	COG0512	Glutamine amidotransferase of anthranilate synthase
DKE45_006255	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DKE45_006260	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DKE45_006265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DKE45_006290	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DKE45_006315	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE45_006320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE45_006390	COG2951	lytic endotransglycosylase activity
DKE45_006395	COG0772	Belongs to the SEDS family
DKE45_006410	COG0842	Transport permease protein
DKE45_006415	COG1131	(ABC) transporter
DKE45_006495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKE45_006510	COG0384	phenazine biosynthesis protein PhzF
DKE45_006555	COG0494	nUDIX hydrolase
DKE45_006570	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DKE45_006575	COG3139	Protein of unknown function (DUF1315)
DKE45_006580	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DKE45_006625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DKE45_006630	COG2195	Cleaves the N-terminal amino acid of tripeptides
DKE45_006650	COG1690	Belongs to the RtcB family
DKE45_006720	COG0778	Nitroreductase
DKE45_006780	COG1610	YqeY-like protein
DKE45_006785	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DKE45_006920	COG2995	paraquat-inducible protein a
DKE45_006935	COG2351	hydroxyisourate hydrolase activity
DKE45_006985	COG0642	Histidine kinase
DKE45_006990	COG0745	RESPONSE REGULATOR receiver
DKE45_007005	COG1794	racemase activity, acting on amino acids and derivatives
DKE45_007035	COG1301	dicarboxylic acid transport
DKE45_007055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DKE45_007075	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DKE45_007115	COG1305	Transglutaminase-like
DKE45_007125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DKE45_007130	COG0305	Participates in initiation and elongation during chromosome replication
DKE45_007155	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DKE45_007205	COG3658	cytochrome
DKE45_007215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE45_007250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE45_007275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE45_007290	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DKE45_007300	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DKE45_007320	COG0745	RESPONSE REGULATOR receiver
DKE45_007325	COG0174	glutamine synthetase
DKE45_007345	COG0729	surface antigen
DKE45_007425	COG0802	atpase or kinase
DKE45_007440	COG1923	regulation of RNA biosynthetic process
DKE45_007445	COG0697	spore germination
DKE45_007475	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKE45_007475	COG0519	Catalyzes the synthesis of GMP from XMP
DKE45_007670	COG1733	regulation of RNA biosynthetic process
DKE45_007695	COG0583	DNA-binding transcription factor activity
DKE45_007735	COG0589	response to stress
DKE45_007790	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_007860	COG1335	isochorismatase
DKE45_007960	COG0511	ligase activity, forming carbon-carbon bonds
DKE45_007990	COG4264	IucA IucC family
DKE45_008015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DKE45_008015	COG1116	anion transmembrane transporter activity
DKE45_008060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DKE45_008075	COG0521	Mo-molybdopterin cofactor biosynthetic process
DKE45_008075	COG0315	cyclic pyranopterin monophosphate synthase activity
DKE45_008120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DKE45_008190	COG2204	response regulator
DKE45_008195	COG3852	Histidine kinase
DKE45_008225	COG0575	Belongs to the CDS family
DKE45_008260	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKE45_008275	COG2137	regulation of response to DNA damage stimulus
DKE45_008290	COG1011	Hydrolase
DKE45_008325	COG0659	secondary active sulfate transmembrane transporter activity
DKE45_008400	COG0024	Methionine aminopeptidase
DKE45_008415	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DKE45_008420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE45_008475	COG4890	Cyd operon protein YbgT
DKE45_008480	COG1294	oxidase, subunit
DKE45_008495	COG1585	Membrane protein implicated in regulation of membrane protease activity
DKE45_008520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DKE45_008565	COG0542	response to heat
DKE45_008575	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DKE45_008630	COG0148	phosphopyruvate hydratase activity
DKE45_008660	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DKE45_008680	COG0183	Belongs to the thiolase family
DKE45_008690	COG0596	Alpha beta hydrolase
DKE45_008695	COG2271	Major facilitator Superfamily
DKE45_008700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DKE45_008710	COG3485	protocatechuate 3,4-dioxygenase
DKE45_008740	COG2391	methyltransferase activity
DKE45_008755	COG1414	Transcriptional regulator
DKE45_008865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKE45_008870	COG0183	Belongs to the thiolase family
DKE45_008890	COG4829	muconolactone delta-isomerase
DKE45_008895	COG4948	Mandelate Racemase Muconate Lactonizing
DKE45_008910	COG2186	Transcriptional regulator
DKE45_008935	COG2351	hydroxyisourate hydrolase activity
DKE45_008940	COG2233	PERMEase
DKE45_008955	COG2186	Transcriptional regulator
DKE45_008995	COG0446	pyridine nucleotide-disulphide oxidoreductase
DKE45_008995	COG1902	pentaerythritol trinitrate reductase activity
DKE45_009035	COG1309	transcriptional regulator
DKE45_009050	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_009055	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_009075	COG0318	PFAM AMP-dependent synthetase and ligase
DKE45_009315	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DKE45_009330	COG2801	Transposase and inactivated derivatives
DKE45_009385	COG4628	conserved protein (DUF2132)
DKE45_009400	COG3539	Fimbrial protein
DKE45_009425	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DKE45_009460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKE45_009480	COG0745	RESPONSE REGULATOR receiver
DKE45_009485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE45_009545	COG1535	isochorismatase
DKE45_009545	COG3433	isochorismatase activity
DKE45_009550	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_009565	COG0725	ABC transporter, periplasmic molybdate-binding protein
DKE45_009575	COG4638	Rieske (2fe-2S)
DKE45_009580	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DKE45_009585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKE45_009585	COG0543	2 iron, 2 sulfur cluster binding
DKE45_009600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE45_009615	COG0412	Dienelactone hydrolase
DKE45_009635	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_009680	COG0583	DNA-binding transcription factor activity
DKE45_009700	COG0183	Belongs to the thiolase family
DKE45_009705	COG0583	DNA-binding transcription factor activity
DKE45_009740	COG0730	response to heat
DKE45_009775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE45_009780	COG0508	dehydrogenase complex catalyzes the overall conversion of
DKE45_009785	COG0022	dehydrogenase e1 component
DKE45_009790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DKE45_009795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE45_009810	COG3706	GGDEF domain
DKE45_009830	COG0133	tryptophan synthase activity
DKE45_009840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DKE45_009870	COG0583	DNA-binding transcription factor activity
DKE45_009875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DKE45_009975	COG0730	response to heat
DKE45_009980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DKE45_010000	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DKE45_010030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DKE45_010050	COG1960	acyl-CoA dehydrogenase activity
DKE45_010055	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DKE45_010095	COG0822	iron-sulfur transferase activity
DKE45_010250	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DKE45_010370	COG1663	tetraacyldisaccharide 4'-kinase activity
DKE45_010375	COG1132	(ABC) transporter
DKE45_010385	COG0811	peptide transport
DKE45_010395	COG1192	Involved in chromosome partitioning
DKE45_010420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DKE45_010445	COG0424	maF-like protein
DKE45_010460	COG0640	Transcriptional regulator
DKE45_010515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKE45_010530	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DKE45_010545	COG3698	Phosphodiester glycosidase
DKE45_010610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DKE45_010610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DKE45_010675	COG0583	DNA-binding transcription factor activity
DKE45_010685	COG2826	transposase and inactivated derivatives, IS30 family
DKE45_010745	COG1522	sequence-specific DNA binding
DKE45_010760	COG1126	abc transporter atp-binding protein
DKE45_010765	COG0765	amino acid transport
DKE45_010770	COG0765	amino acid transport
DKE45_010815	COG2011	ABC-type metal ion transport system permease component
DKE45_010820	COG0012	GTP binding
DKE45_010845	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DKE45_010935	COG3634	alkyl hydroperoxide reductase activity
DKE45_010955	COG0431	NADPH-dependent FMN reductase
DKE45_010970	COG0640	Transcriptional regulator
DKE45_011025	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DKE45_011065	COG1271	oxidase subunit
DKE45_011070	COG1294	oxidase, subunit
DKE45_011080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE45_011135	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DKE45_011160	COG1346	cytolysis
DKE45_011180	COG0625	glutathione transferase activity
DKE45_011245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKE45_011305	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DKE45_011325	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_011415	COG1309	transcriptional regulator
DKE45_011430	COG1024	Enoyl-CoA hydratase
DKE45_011485	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DKE45_011495	COG1960	acyl-CoA dehydrogenase activity
DKE45_011505	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_011510	COG1250	3-hydroxyacyl-CoA dehydrogenase
DKE45_011525	COG2814	Major facilitator Superfamily
DKE45_011530	COG2814	Major facilitator Superfamily
DKE45_011555	COG1960	acyl-CoA dehydrogenase activity
DKE45_011560	COG2814	Major facilitator Superfamily
DKE45_011570	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DKE45_011620	COG0583	DNA-binding transcription factor activity
DKE45_011670	COG2050	protein possibly involved in aromatic compounds catabolism
DKE45_011680	COG3327	negative regulation of DNA-templated transcription, initiation
DKE45_011690	COG0183	Belongs to the thiolase family
DKE45_011700	COG1024	Enoyl-CoA hydratase
DKE45_011705	COG1024	Enoyl-CoA hydratase
DKE45_011715	COG2151	metal-sulfur cluster biosynthetic enzyme
DKE45_011720	COG3396	Phenylacetate-CoA oxygenase
DKE45_011725	COG3460	Phenylacetate-CoA oxygenase
DKE45_011730	COG3396	Phenylacetate-CoA oxygenase
DKE45_011760	COG0789	Transcriptional regulator
DKE45_011770	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DKE45_011795	COG0590	tRNA wobble adenosine to inosine editing
DKE45_011800	COG0666	response to abiotic stimulus
DKE45_011805	COG0583	DNA-binding transcription factor activity
DKE45_011840	COG1063	alcohol dehydrogenase
DKE45_011930	COG4770	biotin carboxylase activity
DKE45_012030	COG0531	amino acid
DKE45_012050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DKE45_012065	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DKE45_012105	COG1538	Outer membrane efflux protein
DKE45_012110	COG1137	ATPase activity
DKE45_012115	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DKE45_012125	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DKE45_012200	COG0668	transmembrane transport
DKE45_012255	COG2226	methyltransferase
DKE45_012295	COG1278	Cold shock
DKE45_012345	COG1570	exodeoxyribonuclease VII activity
DKE45_012430	COG2871	sodium ion transport
DKE45_012450	COG4638	Rieske (2fe-2S)
DKE45_012455	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DKE45_012465	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_012505	COG1643	Atp-dependent helicase
DKE45_012515	COG0450	alkyl hydroperoxide reductase
DKE45_012535	COG3634	alkyl hydroperoxide reductase activity
DKE45_012555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DKE45_012560	COG0625	glutathione transferase activity
DKE45_012570	COG2885	chlorophyll binding
DKE45_012625	COG1765	OsmC-like protein
DKE45_012655	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DKE45_012675	COG0582	viral genome integration into host DNA
DKE45_012690	COG3293	Transposase
DKE45_012765	COG1598	PFAM Uncharacterised protein family UPF0150
DKE45_012960	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DKE45_012970	COG3038	cytochrome b561
DKE45_012975	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DKE45_012990	COG1741	Belongs to the pirin family
DKE45_013110	COG2826	transposase and inactivated derivatives, IS30 family
DKE45_013200	COG4948	Mandelate Racemase Muconate Lactonizing
DKE45_013210	COG2721	sulfolactate sulfo-lyase activity
DKE45_013215	COG0697	spore germination
DKE45_013320	COG2801	Transposase and inactivated derivatives
DKE45_013330	COG4269	membrane
DKE45_013380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DKE45_013410	COG4239	(ABC) transporter, permease
DKE45_013430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DKE45_013475	COG1279	arginine transmembrane transporter activity
DKE45_013495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKE45_013575	COG2878	Part of a membrane complex involved in electron transport
DKE45_013580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DKE45_013635	COG0804	urea catabolic process
DKE45_013665	COG3015	lipoprotein NlpE involved in copper resistance
DKE45_013680	COG1253	flavin adenine dinucleotide binding
DKE45_013735	COG1773	rubredoxin
DKE45_013745	COG2267	carboxylic ester hydrolase activity
DKE45_013750	COG0583	DNA-binding transcription factor activity
DKE45_013830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DKE45_013885	COG2223	nitrite transmembrane transporter activity
DKE45_013895	COG2066	Belongs to the glutaminase family
DKE45_013900	COG0242	peptide deformylase activity
DKE45_013960	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_013985	COG1414	Transcriptional regulator
DKE45_014000	COG1024	Enoyl-CoA hydratase
DKE45_014010	COG1215	transferase activity, transferring glycosyl groups
DKE45_014045	COG1607	acyl-coa hydrolase
DKE45_014160	COG1595	DNA-templated transcription, initiation
DKE45_014170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE45_014285	COG2050	protein possibly involved in aromatic compounds catabolism
DKE45_014345	COG0735	belongs to the Fur family
DKE45_014350	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DKE45_014375	COG0121	glutamine amidotransferase
DKE45_014425	COG2894	cell division
DKE45_014455	COG0492	ferredoxin-NADP+ reductase activity
DKE45_014460	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DKE45_014470	COG0456	acetyltransferase
DKE45_014485	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DKE45_014490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DKE45_014500	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DKE45_014550	COG4638	Rieske (2fe-2S)
DKE45_014570	COG0583	DNA-binding transcription factor activity
DKE45_014590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKE45_014700	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DKE45_014710	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DKE45_014710	COG0352	thiamine-phosphate diphosphorylase activity
DKE45_014710	COG0351	phosphomethylpyrimidine kinase
DKE45_014755	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DKE45_014760	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DKE45_014775	COG4106	trans-aconitate 2-methyltransferase activity
DKE45_014860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE45_014910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DKE45_014965	COG2081	HI0933 family
DKE45_014975	COG0668	transmembrane transport
DKE45_015015	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DKE45_015020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DKE45_015050	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DKE45_015090	COG0745	RESPONSE REGULATOR receiver
DKE45_015105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DKE45_015180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE45_015195	COG0583	DNA-binding transcription factor activity
DKE45_015215	COG1473	amidohydrolase
DKE45_015245	COG0583	DNA-binding transcription factor activity
DKE45_015280	COG1063	alcohol dehydrogenase
DKE45_015315	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DKE45_015320	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DKE45_015325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DKE45_015360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DKE45_015385	COG1214	PFAM Peptidase M22, glycoprotease
DKE45_015445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DKE45_015450	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DKE45_015455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DKE45_015515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DKE45_015525	COG1846	Transcriptional regulator
DKE45_015530	COG1764	response to oxidative stress
DKE45_015580	COG0248	Ppx GppA phosphatase
DKE45_015630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DKE45_015635	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DKE45_015655	COG0625	glutathione transferase activity
DKE45_015675	COG0318	PFAM AMP-dependent synthetase and ligase
DKE45_015685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE45_015760	COG2084	Dehydrogenase
DKE45_015765	COG3622	Belongs to the hyi family
DKE45_015780	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DKE45_015785	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DKE45_015790	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DKE45_015805	COG2814	Major facilitator Superfamily
DKE45_015850	COG0492	ferredoxin-NADP+ reductase activity
DKE45_015855	COG0431	NADPH-dependent FMN reductase
DKE45_015870	COG0640	Transcriptional regulator
DKE45_015920	COG3328	transposase activity
DKE45_015950	COG2205	protein histidine kinase activity
DKE45_016045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE45_016120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DKE45_016125	COG0440	acetolactate synthase activity
DKE45_016150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE45_016190	COG1162	GTPase activity
DKE45_016200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DKE45_016220	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DKE45_016305	COG3265	gluconokinase activity
DKE45_016390	COG2813	Specifically methylates the guanine in position
DKE45_016390	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKE45_016490	COG0788	formyltetrahydrofolate deformylase activity
DKE45_016505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DKE45_016515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DKE45_016515	COG4651	solute:proton antiporter activity
DKE45_016535	COG0724	RNA recognition motif
DKE45_016565	COG1733	regulation of RNA biosynthetic process
DKE45_016575	COG2900	Belongs to the SlyX family
DKE45_016590	COG1560	Kdo2-lipid A biosynthetic process
DKE45_016600	COG1301	dicarboxylic acid transport
DKE45_016720	COG0583	DNA-binding transcription factor activity
DKE45_016735	COG2378	regulation of single-species biofilm formation
DKE45_016740	COG0546	phosphoglycolate phosphatase activity
DKE45_016775	COG0583	DNA-binding transcription factor activity
DKE45_016785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DKE45_016810	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DKE45_016835	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKE45_016835	COG0493	'glutamate synthase
DKE45_016845	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DKE45_016850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE45_016865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DKE45_016890	COG4535	Mg2 and Co2 transporter CorC
DKE45_016930	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DKE45_016945	COG0789	Transcriptional regulator
DKE45_016950	COG0598	Magnesium transport protein CorA
DKE45_016955	COG1185	polyribonucleotide nucleotidyltransferase activity
DKE45_016970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DKE45_017000	COG2226	methyltransferase
DKE45_017055	COG1006	Multisubunit Na H antiporter MnhC subunit
DKE45_017070	COG2212	antiporter activity
DKE45_017080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DKE45_017150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DKE45_017165	COG0497	DNA recombination
DKE45_017215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DKE45_017290	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DKE45_017320	COG2056	Na+-H+ antiporter family
DKE45_017395	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DKE45_017425	COG0546	phosphoglycolate phosphatase activity
DKE45_017430	COG1716	ATPase activity
DKE45_017515	COG0697	spore germination
DKE45_017535	COG0494	nUDIX hydrolase
DKE45_017540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DKE45_017580	COG4974	Belongs to the 'phage' integrase family
DKE45_017595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DKE45_017605	COG2197	response regulator
DKE45_017625	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DKE45_017685	COG0347	Belongs to the P(II) protein family
DKE45_017695	COG0606	chelatase, subunit chli
DKE45_017715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE45_017735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DKE45_017760	COG0477	Major facilitator Superfamily
DKE45_017765	COG2860	membrane
DKE45_017775	COG1253	flavin adenine dinucleotide binding
DKE45_017795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DKE45_017835	COG0655	NAD(P)H dehydrogenase (quinone) activity
DKE45_017850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DKE45_017925	COG0697	spore germination
DKE45_017960	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DKE45_017970	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DKE45_018010	COG1121	(ABC) transporter
DKE45_018015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DKE45_018025	COG2837	iron assimilation
DKE45_018090	COG2259	Doxx family
DKE45_018120	COG0271	Belongs to the BolA IbaG family
DKE45_018150	COG3321	synthase
DKE45_018150	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DKE45_018150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DKE45_018150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKE45_018175	COG3916	Acyl-homoserine-lactone synthase
DKE45_018195	COG1113	amino acid transport
DKE45_018215	COG1024	Enoyl-CoA hydratase
DKE45_018220	COG1960	acyl-CoA dehydrogenase activity
DKE45_018225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DKE45_018260	COG0251	oxidation-reduction process
DKE45_018275	COG1522	sequence-specific DNA binding
DKE45_018300	COG0564	pseudouridine synthase activity
DKE45_018395	COG1802	Transcriptional regulator
DKE45_018410	COG0277	FAD linked oxidase domain protein
DKE45_018445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DKE45_018450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DKE45_018490	COG1091	dTDP-4-dehydrorhamnose reductase activity
DKE45_018605	COG0546	phosphoglycolate phosphatase activity
DKE45_018610	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_018625	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DKE45_018625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DKE45_018640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE45_018645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE45_018655	COG1309	transcriptional regulator
DKE45_018670	COG0196	riboflavin kinase activity
DKE45_018685	COG1047	Peptidyl-prolyl cis-trans
DKE45_018725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DKE45_018800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DKE45_018815	COG0861	Integral membrane protein TerC family
DKE45_018850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DKE45_018885	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DKE45_018905	COG2801	Transposase and inactivated derivatives
DKE45_018920	COG1192	Involved in chromosome partitioning
DKE45_019145	COG4783	chaperone-mediated protein folding
DKE45_019160	COG2801	Transposase and inactivated derivatives
DKE45_019270	COG3316	Transposase and inactivated derivatives
DKE45_019305	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DKE45_019350	COG1538	Outer membrane efflux protein
DKE45_019365	COG3316	Transposase and inactivated derivatives
DKE45_019455	COG3316	Transposase and inactivated derivatives
DKE45_019515	COG0789	Transcriptional regulator
DKE45_019545	COG0789	Transcriptional regulator
DKE45_019620	COG0583	DNA-binding transcription factor activity
DKE45_019645	COG0860	N-Acetylmuramoyl-L-alanine amidase
DKE45_019675	COG0251	oxidation-reduction process
DKE45_019690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DKE45_019700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DKE45_019705	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DKE45_019945	COG1525	nuclease
DKE45_020095	COG1484	DNA-dependent DNA replication
DKE45_020280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DKE45_020330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE45_020360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DKE45_020365	COG0625	glutathione transferase activity
DKE45_020405	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DKE45_020415	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DKE45_020435	COG2009	succinate dehydrogenase
DKE45_020695	COG3321	synthase
DKE45_020695	COG0604	alcohol dehydrogenase
DKE45_021010	COG0604	alcohol dehydrogenase