locus-tag	class	description
DKE52_000010	COG0592	DNA-directed DNA polymerase activity
DKE52_000215	COG0583	DNA-binding transcription factor activity
DKE52_000255	COG1194	a g-specific adenine glycosylase
DKE52_000270	COG5487	UPF0391 membrane protein
DKE52_000275	COG2983	Belongs to the UPF0260 family
DKE52_000290	COG2116	formate transmembrane transporter activity
DKE52_000310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE52_000315	COG1335	isochorismatase
DKE52_000330	COG1683	Conserved Protein
DKE52_000480	COG3830	Belongs to the UPF0237 family
DKE52_000480	COG0560	Phosphoserine phosphatase
DKE52_000565	COG0436	Aminotransferase
DKE52_000625	COG3150	esterase
DKE52_000635	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DKE52_000650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKE52_000660	COG2233	PERMEase
DKE52_000665	COG2351	hydroxyisourate hydrolase activity
DKE52_000720	COG0708	Exodeoxyribonuclease III
DKE52_000745	COG0189	ligase activity
DKE52_000765	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DKE52_000820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE52_000820	COG0426	domain, Protein
DKE52_000900	COG1522	sequence-specific DNA binding
DKE52_000965	COG1309	transcriptional regulator
DKE52_000985	COG0351	phosphomethylpyrimidine kinase
DKE52_000985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DKE52_000985	COG0352	thiamine-phosphate diphosphorylase activity
DKE52_001045	COG1335	isochorismatase
DKE52_001115	COG0667	Aldo Keto reductase
DKE52_001250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DKE52_001265	COG2329	Antibiotic biosynthesis monooxygenase
DKE52_001270	COG0697	spore germination
DKE52_001300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DKE52_001345	COG0745	RESPONSE REGULATOR receiver
DKE52_001360	COG4221	oxidoreductase activity
DKE52_001500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DKE52_001700	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DKE52_001710	COG0335	large ribosomal subunit rRNA binding
DKE52_001745	COG5006	permease, DMT superfamily
DKE52_001750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DKE52_001765	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DKE52_001805	COG1192	Involved in chromosome partitioning
DKE52_001840	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DKE52_001895	COG0583	DNA-binding transcription factor activity
DKE52_001920	COG0752	glycyl-tRNA synthetase alpha subunit
DKE52_001950	COG1983	PspC domain protein
DKE52_001975	COG0408	coproporphyrinogen oxidase activity
DKE52_002010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DKE52_002030	COG0598	Magnesium transport protein CorA
DKE52_002040	COG0494	nUDIX hydrolase
DKE52_002095	COG1017	nitric oxide dioxygenase activity
DKE52_002095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKE52_002110	COG0626	cystathionine gamma-synthase activity
DKE52_002125	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DKE52_002130	COG0088	Forms part of the polypeptide exit tunnel
DKE52_002230	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DKE52_002265	COG1960	acyl-CoA dehydrogenase activity
DKE52_002270	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DKE52_002300	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DKE52_002360	COG0179	Fumarylacetoacetate (FAA) hydrolase
DKE52_002410	COG1196	nuclear chromosome segregation
DKE52_002410	COG0739	heme binding
DKE52_002410	COG0741	lytic transglycosylase activity
DKE52_002445	COG1183	phosphatidylcholine synthase activity
DKE52_002495	COG1309	transcriptional regulator
DKE52_002580	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DKE52_002585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DKE52_002590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DKE52_002695	COG3453	Protein conserved in bacteria
DKE52_002695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE52_002710	COG1607	acyl-coa hydrolase
DKE52_002960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DKE52_002970	COG1862	Preprotein translocase
DKE52_003005	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DKE52_003105	COG0583	DNA-binding transcription factor activity
DKE52_003160	COG2096	Adenosyltransferase
DKE52_003230	COG0450	alkyl hydroperoxide reductase
DKE52_003260	COG2153	protein acetylation
DKE52_003285	COG2207	Transcriptional regulator
DKE52_003305	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DKE52_003335	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DKE52_003335	COG2885	chlorophyll binding
DKE52_003345	COG0833	amino acid
DKE52_003385	COG2094	Belongs to the DNA glycosylase MPG family
DKE52_003390	COG4772	TonB-dependent receptor
DKE52_003395	COG4772	TonB-dependent receptor
DKE52_003450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE52_003455	COG0251	oxidation-reduction process
DKE52_003465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE52_003480	COG3189	MarR family transcriptional regulator
DKE52_003490	COG3422	double-strand break repair
DKE52_003530	COG0840	transmembrane signaling receptor activity
DKE52_003560	COG2832	Protein of unknown function (DUF454)
DKE52_003655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DKE52_003700	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DKE52_003710	COG1792	Involved in formation and maintenance of cell shape
DKE52_003715	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DKE52_003720	COG0424	maF-like protein
DKE52_003810	COG2828	Protein conserved in bacteria
DKE52_003860	COG2194	sulfuric ester hydrolase activity
DKE52_003890	COG0583	DNA-binding transcription factor activity
DKE52_003910	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DKE52_003980	COG0671	phosphoesterase, PA-phosphatase related
DKE52_004010	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DKE52_004030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DKE52_004085	COG2921	Belongs to the UPF0250 family
DKE52_004125	COG2009	succinate dehydrogenase
DKE52_004140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DKE52_004405	COG0589	response to stress
DKE52_004415	COG0251	oxidation-reduction process
DKE52_004435	COG0505	Belongs to the CarA family
DKE52_004615	COG0741	lytic transglycosylase activity
DKE52_004720	COG0778	Nitroreductase
DKE52_004745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DKE52_004845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE52_004900	COG0616	signal peptide processing
DKE52_004900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DKE52_004905	COG0596	Alpha beta hydrolase
DKE52_004910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DKE52_004980	COG0823	Involved in the tonB-independent uptake of proteins
DKE52_005000	COG0824	Thioesterase
DKE52_005025	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DKE52_005025	COG0047	phosphoribosylformylglycinamidine synthase activity
DKE52_005040	COG1024	Enoyl-CoA hydratase
DKE52_005045	COG1051	belongs to the nudix hydrolase family
DKE52_005045	COG1056	cytidyltransferase-related domain
DKE52_005075	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DKE52_005090	COG4625	pathogenesis
DKE52_005095	COG0583	DNA-binding transcription factor activity
DKE52_005100	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DKE52_005110	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DKE52_005120	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DKE52_005195	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DKE52_005255	COG0556	nucleotide-excision repair
DKE52_005265	COG2962	Rard protein
DKE52_005385	COG1187	pseudouridine synthase activity
DKE52_005485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKE52_005520	COG3961	Belongs to the TPP enzyme family
DKE52_005585	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DKE52_005590	COG1686	Belongs to the peptidase S11 family
DKE52_005615	COG0583	DNA-binding transcription factor activity
DKE52_005670	COG2879	small protein
DKE52_005685	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DKE52_005730	COG1741	Belongs to the pirin family
DKE52_005760	COG4604	ABC transporter, ATP-binding protein
DKE52_005865	COG0302	gtp cyclohydrolase
DKE52_005915	COG0512	Glutamine amidotransferase of anthranilate synthase
DKE52_005975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DKE52_006005	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DKE52_006035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE52_006050	COG2223	nitrite transmembrane transporter activity
DKE52_006060	COG0024	Methionine aminopeptidase
DKE52_006125	COG0842	Transport permease protein
DKE52_006205	COG4197	protein conserved in bacteria, prophage-related
DKE52_006460	COG1538	Outer membrane efflux protein
DKE52_006505	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKE52_006555	COG0642	Histidine kinase
DKE52_006585	COG3139	Protein of unknown function (DUF1315)
DKE52_006590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DKE52_006605	COG1960	acyl-CoA dehydrogenase activity
DKE52_006630	COG2195	Cleaves the N-terminal amino acid of tripeptides
DKE52_006650	COG1690	Belongs to the RtcB family
DKE52_006700	COG1278	Cold shock
DKE52_006705	COG0513	Belongs to the DEAD box helicase family
DKE52_006715	COG0778	Nitroreductase
DKE52_006775	COG1610	YqeY-like protein
DKE52_006805	COG2815	serine threonine protein kinase
DKE52_006805	COG0515	serine threonine protein kinase
DKE52_006845	COG3243	poly(R)-hydroxyalkanoic acid synthase
DKE52_006850	COG0786	glutamate:sodium symporter activity
DKE52_006985	COG1794	racemase activity, acting on amino acids and derivatives
DKE52_007000	COG3246	L-lysine catabolic process to acetate
DKE52_007065	COG1301	dicarboxylic acid transport
DKE52_007075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE52_007085	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DKE52_007105	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DKE52_007145	COG1305	Transglutaminase-like
DKE52_007185	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DKE52_007190	COG1845	cytochrome c oxidase, subunit III
DKE52_007235	COG3658	cytochrome
DKE52_007275	COG2890	protein-(glutamine-N5) methyltransferase activity
DKE52_007320	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DKE52_007330	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DKE52_007470	COG1187	pseudouridine synthase activity
DKE52_007490	COG0802	atpase or kinase
DKE52_007505	COG1923	regulation of RNA biosynthetic process
DKE52_007540	COG0519	Catalyzes the synthesis of GMP from XMP
DKE52_007540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKE52_007555	COG0531	amino acid
DKE52_007645	COG1605	Chorismate mutase
DKE52_007660	COG4772	TonB-dependent receptor
DKE52_007730	COG0583	DNA-binding transcription factor activity
DKE52_007805	COG3135	benzoate transporter
DKE52_007810	COG1522	sequence-specific DNA binding
DKE52_007835	COG0183	Belongs to the thiolase family
DKE52_007885	COG0824	Thioesterase
DKE52_007890	COG1454	alcohol dehydrogenase
DKE52_007915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DKE52_007945	COG0069	glutamate synthase activity
DKE52_008370	COG1476	TRANSCRIPTIONal
DKE52_008390	COG0511	ligase activity, forming carbon-carbon bonds
DKE52_008460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DKE52_008545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DKE52_008565	COG0596	Alpha beta hydrolase
DKE52_008645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DKE52_008650	COG0575	Belongs to the CDS family
DKE52_008700	COG2137	regulation of response to DNA damage stimulus
DKE52_008715	COG1011	Hydrolase
DKE52_008760	COG0659	secondary active sulfate transmembrane transporter activity
DKE52_008850	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DKE52_008855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE52_008905	COG4890	Cyd operon protein YbgT
DKE52_008910	COG1294	oxidase, subunit
DKE52_008925	COG1585	Membrane protein implicated in regulation of membrane protease activity
DKE52_008990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DKE52_009060	COG0148	phosphopyruvate hydratase activity
DKE52_009065	COG2323	membrane
DKE52_009075	COG4773	Receptor
DKE52_009080	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DKE52_009110	COG0596	Alpha beta hydrolase
DKE52_009130	COG3485	protocatechuate 3,4-dioxygenase
DKE52_009175	COG1414	Transcriptional regulator
DKE52_009250	COG1028	Short-chain dehydrogenase reductase Sdr
DKE52_009285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKE52_009300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DKE52_009310	COG4829	muconolactone delta-isomerase
DKE52_009375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKE52_009405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE52_009465	COG1309	transcriptional regulator
DKE52_009470	COG0583	DNA-binding transcription factor activity
DKE52_009480	COG1028	Short-chain dehydrogenase reductase Sdr
DKE52_009595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DKE52_009670	COG1012	belongs to the aldehyde dehydrogenase family
DKE52_009675	COG1012	belongs to the aldehyde dehydrogenase family
DKE52_009705	COG2084	Dehydrogenase
DKE52_009725	COG1120	ATPase activity
DKE52_009855	COG2175	clavaminate synthase activity
DKE52_009860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DKE52_009925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE52_010055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DKE52_010160	COG0745	RESPONSE REGULATOR receiver
DKE52_010165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE52_010225	COG3433	isochorismatase activity
DKE52_010225	COG1535	isochorismatase
DKE52_010230	COG1028	Short-chain dehydrogenase reductase Sdr
DKE52_010315	COG1028	Short-chain dehydrogenase reductase Sdr
DKE52_010360	COG0732	type I restriction modification DNA specificity domain
DKE52_010430	COG4584	PFAM Integrase catalytic
DKE52_010520	COG0583	DNA-binding transcription factor activity
DKE52_010540	COG1027	Aspartate ammonia-lyase
DKE52_010625	COG1063	alcohol dehydrogenase
DKE52_010645	COG0022	dehydrogenase e1 component
DKE52_010650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DKE52_010840	COG0730	response to heat
DKE52_010845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DKE52_010965	COG0822	iron-sulfur transferase activity
DKE52_011025	COG0702	epimerase
DKE52_011065	COG0601	transmembrane transport
DKE52_011070	COG0339	signal peptide processing
DKE52_011155	COG0776	regulation of translation
DKE52_011175	COG0590	tRNA wobble adenosine to inosine editing
DKE52_011240	COG1663	tetraacyldisaccharide 4'-kinase activity
DKE52_011245	COG1132	(ABC) transporter
DKE52_011330	COG0640	Transcriptional regulator
DKE52_011375	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DKE52_011395	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DKE52_011430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DKE52_011545	COG0583	DNA-binding transcription factor activity
DKE52_011565	COG1309	transcriptional regulator
DKE52_011580	COG1522	sequence-specific DNA binding
DKE52_011590	COG1126	abc transporter atp-binding protein
DKE52_011645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DKE52_011650	COG2011	ABC-type metal ion transport system permease component
DKE52_011680	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DKE52_011785	COG0583	DNA-binding transcription factor activity
DKE52_011790	COG0431	NADPH-dependent FMN reductase
DKE52_011805	COG0640	Transcriptional regulator
DKE52_011830	COG0583	DNA-binding transcription factor activity
DKE52_011855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE52_011865	COG4521	taurine ABC transporter
DKE52_011900	COG1271	oxidase subunit
DKE52_011920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE52_011945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DKE52_011990	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DKE52_012025	COG1346	cytolysis
DKE52_012035	COG0583	DNA-binding transcription factor activity
DKE52_012040	COG0625	glutathione transferase activity
DKE52_012045	COG0625	glutathione transferase activity
DKE52_012095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKE52_012105	COG0765	amino acid transport
DKE52_012110	COG0765	amino acid transport
DKE52_012155	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DKE52_012240	COG2814	Major facilitator Superfamily
DKE52_012265	COG1309	transcriptional regulator
DKE52_012270	COG1960	acyl-CoA dehydrogenase activity
DKE52_012320	COG2814	Major facilitator Superfamily
DKE52_012325	COG2814	Major facilitator Superfamily
DKE52_012360	COG1024	Enoyl-CoA hydratase
DKE52_012420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DKE52_012480	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DKE52_012495	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DKE52_012505	COG1012	belongs to the aldehyde dehydrogenase family
DKE52_012515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE52_012520	COG2267	carboxylic ester hydrolase activity
DKE52_012585	COG0406	alpha-ribazole phosphatase activity
DKE52_012605	COG2050	protein possibly involved in aromatic compounds catabolism
DKE52_012635	COG1024	Enoyl-CoA hydratase
DKE52_012650	COG2151	metal-sulfur cluster biosynthetic enzyme
DKE52_012660	COG3460	Phenylacetate-CoA oxygenase
DKE52_012665	COG3396	Phenylacetate-CoA oxygenase
DKE52_012675	COG1760	l-serine dehydratase
DKE52_012745	COG0789	Transcriptional regulator
DKE52_012755	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DKE52_012935	COG1116	anion transmembrane transporter activity
DKE52_012950	COG0864	Transcriptional regulator
DKE52_012960	COG1733	regulation of RNA biosynthetic process
DKE52_012985	COG1063	alcohol dehydrogenase
DKE52_012990	COG1063	alcohol dehydrogenase
DKE52_012995	COG1250	3-hydroxyacyl-CoA dehydrogenase
DKE52_013040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DKE52_013050	COG4770	biotin carboxylase activity
DKE52_013095	COG3220	belongs to the UPF0276 family
DKE52_013155	COG1733	regulation of RNA biosynthetic process
DKE52_013245	COG3038	cytochrome b561
DKE52_013270	COG1073	alpha beta
DKE52_013275	COG1073	alpha beta
DKE52_013295	COG1522	sequence-specific DNA binding
DKE52_013300	COG0531	amino acid
DKE52_013335	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DKE52_013345	COG4122	O-methyltransferase activity
DKE52_013385	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DKE52_013395	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DKE52_013430	COG1733	regulation of RNA biosynthetic process
DKE52_013695	COG0583	DNA-binding transcription factor activity
DKE52_013725	COG1028	Short-chain dehydrogenase reductase Sdr
DKE52_013795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DKE52_013895	COG1765	OsmC-like protein
DKE52_013925	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DKE52_014190	COG5410	chromosome segregation
DKE52_014375	COG1741	Belongs to the pirin family
DKE52_014380	COG1309	transcriptional regulator
DKE52_014390	COG0300	oxidoreductase activity
DKE52_014415	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DKE52_014555	COG1012	belongs to the aldehyde dehydrogenase family
DKE52_014825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DKE52_014955	COG3384	dioxygenase
DKE52_015060	COG3015	lipoprotein NlpE involved in copper resistance
DKE52_015130	COG1773	rubredoxin
DKE52_015140	COG2267	carboxylic ester hydrolase activity
DKE52_015225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DKE52_015270	COG3959	Transketolase, thiamine diphosphate binding domain
DKE52_015325	COG0242	peptide deformylase activity
DKE52_015360	COG2267	carboxylic ester hydrolase activity
DKE52_015430	COG1215	transferase activity, transferring glycosyl groups
DKE52_015445	COG4681	YaeQ
DKE52_015465	COG1607	acyl-coa hydrolase
DKE52_015570	COG1595	DNA-templated transcription, initiation
DKE52_015865	COG3755	Protein conserved in bacteria
DKE52_015910	COG1484	DNA-dependent DNA replication
DKE52_016125	COG0420	3'-5' exonuclease activity
DKE52_016150	COG0735	belongs to the Fur family
DKE52_016160	COG2914	Belongs to the UPF0125 (RnfH) family
DKE52_016180	COG0121	glutamine amidotransferase
DKE52_016210	COG2885	chlorophyll binding
DKE52_016230	COG2894	cell division
DKE52_016255	COG0492	ferredoxin-NADP+ reductase activity
DKE52_016270	COG0456	acetyltransferase
DKE52_016285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DKE52_016300	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DKE52_016370	COG0583	DNA-binding transcription factor activity
DKE52_016390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKE52_016500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DKE52_016525	COG1028	Short-chain dehydrogenase reductase Sdr
DKE52_016540	COG1399	metal-binding, possibly nucleic acid-binding protein
DKE52_016545	COG3101	peptidyl-lysine hydroxylation
DKE52_016550	COG0009	L-threonylcarbamoyladenylate synthase
DKE52_016555	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DKE52_016560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DKE52_016575	COG4106	trans-aconitate 2-methyltransferase activity
DKE52_016770	COG2081	HI0933 family
DKE52_016820	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DKE52_016855	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DKE52_016880	COG2199	diguanylate cyclase activity
DKE52_016890	COG2205	protein histidine kinase activity
DKE52_016910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DKE52_017035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE52_017120	COG1309	transcriptional regulator
DKE52_017230	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DKE52_017240	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DKE52_017325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DKE52_017330	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DKE52_017395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DKE52_017405	COG1846	Transcriptional regulator
DKE52_017410	COG1764	response to oxidative stress
DKE52_017515	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DKE52_017535	COG0625	glutathione transferase activity
DKE52_017555	COG0318	PFAM AMP-dependent synthetase and ligase
DKE52_017565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE52_017665	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DKE52_017690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE52_017770	COG0440	acetolactate synthase activity
DKE52_017835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DKE52_017855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DKE52_017860	COG1028	Short-chain dehydrogenase reductase Sdr
DKE52_017900	COG2986	histidine ammonia-lyase
DKE52_017925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKE52_017950	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DKE52_017970	COG1426	Protein conserved in bacteria
DKE52_018030	COG1012	belongs to the aldehyde dehydrogenase family
DKE52_018035	COG3265	gluconokinase activity
DKE52_018045	COG0800	Aldolase
DKE52_018060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DKE52_018070	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DKE52_018070	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DKE52_018120	COG2813	Specifically methylates the guanine in position
DKE52_018120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKE52_018235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DKE52_018265	COG0724	RNA recognition motif
DKE52_018300	COG0604	alcohol dehydrogenase
DKE52_018305	COG2900	Belongs to the SlyX family
DKE52_018410	COG0583	DNA-binding transcription factor activity
DKE52_018460	COG0625	glutathione transferase activity
DKE52_018465	COG2378	regulation of single-species biofilm formation
DKE52_018580	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DKE52_018585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE52_018600	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DKE52_018625	COG4535	Mg2 and Co2 transporter CorC
DKE52_018680	COG0789	Transcriptional regulator
DKE52_018685	COG0598	Magnesium transport protein CorA
DKE52_018735	COG2226	methyltransferase
DKE52_018785	COG1006	Multisubunit Na H antiporter MnhC subunit
DKE52_018800	COG2212	antiporter activity
DKE52_018810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DKE52_018880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DKE52_018945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DKE52_019050	COG2056	Na+-H+ antiporter family
DKE52_019150	COG0546	phosphoglycolate phosphatase activity
DKE52_019200	COG0181	hydroxymethylbilane synthase activity
DKE52_019240	COG0697	spore germination
DKE52_019260	COG0494	nUDIX hydrolase
DKE52_019265	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DKE52_019270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DKE52_019280	COG0772	Belongs to the SEDS family
DKE52_019305	COG4974	Belongs to the 'phage' integrase family
DKE52_019310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DKE52_019320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DKE52_019330	COG2197	response regulator
DKE52_019425	COG0431	NADPH-dependent FMN reductase
DKE52_019440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE52_019490	COG2860	membrane
DKE52_019515	COG2814	Major facilitator Superfamily
DKE52_019565	COG0655	NAD(P)H dehydrogenase (quinone) activity
DKE52_019655	COG0697	spore germination
DKE52_019660	COG1309	transcriptional regulator
DKE52_019690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DKE52_019745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DKE52_019810	COG4399	Belongs to the UPF0754 family
DKE52_019845	COG0271	Belongs to the BolA IbaG family
DKE52_019890	COG3321	synthase
DKE52_019890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DKE52_019890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKE52_019890	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DKE52_019920	COG0477	Major facilitator Superfamily
DKE52_019925	COG1024	Enoyl-CoA hydratase
DKE52_019960	COG1113	amino acid transport
DKE52_019970	COG0251	oxidation-reduction process
DKE52_020065	COG1051	belongs to the nudix hydrolase family
DKE52_020115	COG1802	Transcriptional regulator
DKE52_020125	COG1448	Aminotransferase
DKE52_020140	COG2186	Transcriptional regulator
DKE52_020175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DKE52_020255	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DKE52_020260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DKE52_020365	COG0546	phosphoglycolate phosphatase activity
DKE52_020370	COG1028	Short-chain dehydrogenase reductase Sdr
DKE52_020400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE52_020405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE52_020420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DKE52_020540	COG2951	lytic endotransglycosylase activity
DKE52_020630	COG1230	cation diffusion facilitator family transporter
DKE52_020660	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DKE52_020745	COG1012	belongs to the aldehyde dehydrogenase family
DKE52_020790	COG3550	peptidyl-serine autophosphorylation
DKE52_020870	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DKE52_020970	COG0456	acetyltransferase
DKE52_021000	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DKE52_021155	COG1192	Involved in chromosome partitioning
DKE52_021325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DKE52_021385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins