locus-tag	class	description
I6J44_00025	COG1607	acyl-coa hydrolase
I6J44_00095	COG2199	diguanylate cyclase activity
I6J44_00100	COG2885	chlorophyll binding
I6J44_00100	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J44_00105	COG1408	metallophosphoesterase
I6J44_00110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J44_00120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J44_00140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J44_00145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J44_00150	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6J44_00155	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J44_00160	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J44_00165	COG0625	glutathione transferase activity
I6J44_00170	COG2969	positive regulation of protein catabolic process
I6J44_00210	COG1960	acyl-CoA dehydrogenase activity
I6J44_00215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J44_00230	COG1309	transcriptional regulator
I6J44_00235	COG1960	acyl-CoA dehydrogenase activity
I6J44_00280	COG1183	phosphatidylcholine synthase activity
I6J44_00285	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6J44_00315	COG1196	nuclear chromosome segregation
I6J44_00315	COG0739	heme binding
I6J44_00315	COG0741	lytic transglycosylase activity
I6J44_00325	COG1702	phosphate starvation-inducible protein PhoH
I6J44_00360	COG1295	ribonuclease BN
I6J44_00365	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J44_00415	COG0557	exoribonuclease II activity
I6J44_00420	COG0339	signal peptide processing
I6J44_00425	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6J44_00455	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6J44_00460	COG1960	acyl-CoA dehydrogenase activity
I6J44_00595	COG0088	Forms part of the polypeptide exit tunnel
I6J44_00600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J44_00615	COG0626	cystathionine gamma-synthase activity
I6J44_00620	COG0433	COG0433 Predicted ATPase
I6J44_00630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J44_00630	COG1017	nitric oxide dioxygenase activity
I6J44_00635	COG1959	2 iron, 2 sulfur cluster binding
I6J44_00650	COG1301	dicarboxylic acid transport
I6J44_00655	COG1946	Acyl-CoA thioesterase
I6J44_00675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J44_00680	COG1040	competence protein
I6J44_00685	COG0494	nUDIX hydrolase
I6J44_00695	COG0598	Magnesium transport protein CorA
I6J44_00705	COG2854	intermembrane phospholipid transfer
I6J44_00715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J44_00720	COG1127	ABC transporter
I6J44_00730	COG0513	Belongs to the DEAD box helicase family
I6J44_00750	COG0408	coproporphyrinogen oxidase activity
I6J44_00765	COG1960	acyl-CoA dehydrogenase activity
I6J44_00775	COG1983	PspC domain protein
I6J44_00780	COG0517	IMP dehydrogenase activity
I6J44_00805	COG0752	glycyl-tRNA synthetase alpha subunit
I6J44_00830	COG0583	DNA-binding transcription factor activity
I6J44_00870	COG1012	belongs to the aldehyde dehydrogenase family
I6J44_00880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J44_00885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J44_00890	COG0833	amino acid
I6J44_00895	COG2826	transposase and inactivated derivatives, IS30 family
I6J44_00925	COG1192	Involved in chromosome partitioning
I6J44_00930	COG0628	permease
I6J44_00940	COG1289	transmembrane transporter activity
I6J44_00955	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J44_00960	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6J44_00970	COG0277	FAD linked oxidase domain protein
I6J44_00975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J44_00985	COG5006	permease, DMT superfamily
I6J44_01000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J44_01005	COG5380	lipid catabolic process
I6J44_01015	COG0335	large ribosomal subunit rRNA binding
I6J44_01025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J44_01075	COG0194	GDP metabolic process
I6J44_01090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J44_01115	COG3307	-O-antigen
I6J44_01125	COG4969	Belongs to the N-Me-Phe pilin family
I6J44_01135	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6J44_01140	COG1704	LemA family
I6J44_01150	COG0493	'glutamate synthase
I6J44_01155	COG0067	glutamate synthase
I6J44_01155	COG0069	glutamate synthase activity
I6J44_01155	COG0070	glutamate synthase
I6J44_01205	COG2226	methyltransferase
I6J44_01220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J44_01225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J44_01270	COG0833	amino acid
I6J44_01350	COG0488	(ABC) transporter
I6J44_01355	COG2873	o-acetylhomoserine
I6J44_01360	COG4221	oxidoreductase activity
I6J44_01365	COG0659	secondary active sulfate transmembrane transporter activity
I6J44_01390	COG0427	acetyl-CoA hydrolase
I6J44_01420	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J44_01460	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J44_01520	COG0582	viral genome integration into host DNA
I6J44_01545	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J44_01610	COG2814	Major facilitator Superfamily
I6J44_01675	COG2207	Transcriptional regulator
I6J44_01680	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6J44_01690	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J44_01695	COG1733	regulation of RNA biosynthetic process
I6J44_01740	COG0667	Aldo Keto reductase
I6J44_01760	COG0583	DNA-binding transcription factor activity
I6J44_01765	COG2814	Major facilitator Superfamily
I6J44_01840	COG2826	transposase and inactivated derivatives, IS30 family
I6J44_01875	COG1335	isochorismatase
I6J44_01885	COG1012	belongs to the aldehyde dehydrogenase family
I6J44_01890	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J44_01900	COG1113	amino acid transport
I6J44_01910	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J44_01925	COG2814	Major facilitator Superfamily
I6J44_01935	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J44_01935	COG0352	thiamine-phosphate diphosphorylase activity
I6J44_01935	COG0351	phosphomethylpyrimidine kinase
I6J44_01940	COG0789	Transcriptional regulator
I6J44_01945	COG0300	oxidoreductase activity
I6J44_01965	COG1309	transcriptional regulator
I6J44_01990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J44_02000	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J44_02005	COG3162	membrane
I6J44_02010	COG2198	Histidine kinase
I6J44_02010	COG0784	Response regulator, receiver
I6J44_02010	COG2205	protein histidine kinase activity
I6J44_02030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J44_02035	COG1522	sequence-specific DNA binding
I6J44_02040	COG1335	isochorismatase
I6J44_02045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J44_02055	COG0668	transmembrane transport
I6J44_02060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J44_02065	COG1519	Transferase
I6J44_02070	COG1902	pentaerythritol trinitrate reductase activity
I6J44_02090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J44_02110	COG0426	domain, Protein
I6J44_02110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J44_02115	COG4774	siderophore transport
I6J44_02120	COG2119	membrane
I6J44_02130	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J44_02140	COG4942	peptidase
I6J44_02155	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J44_02165	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6J44_02185	COG0189	ligase activity
I6J44_02205	COG0708	Exodeoxyribonuclease III
I6J44_02210	COG1393	Belongs to the ArsC family
I6J44_02225	COG3706	GGDEF domain
I6J44_02260	COG2351	hydroxyisourate hydrolase activity
I6J44_02265	COG2233	PERMEase
I6J44_02275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J44_02285	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6J44_02295	COG3150	esterase
I6J44_02340	COG2918	glutathione biosynthetic process
I6J44_02355	COG2733	membrane
I6J44_02360	COG0436	Aminotransferase
I6J44_02365	COG0534	Mate efflux family protein
I6J44_02395	COG2826	transposase and inactivated derivatives, IS30 family
I6J44_02470	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6J44_02475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6J44_02485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J44_02520	COG0010	Belongs to the arginase family
I6J44_02550	COG2188	Transcriptional regulator
I6J44_02560	COG0523	cobalamin synthesis protein
I6J44_02570	COG1113	amino acid transport
I6J44_02580	COG0625	glutathione transferase activity
I6J44_02585	COG0346	lactoylglutathione lyase activity
I6J44_02600	COG1683	Conserved Protein
I6J44_02605	COG0534	Mate efflux family protein
I6J44_02610	COG0385	Bile acid
I6J44_02615	COG1335	isochorismatase
I6J44_02620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J44_02640	COG2116	formate transmembrane transporter activity
I6J44_02645	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J44_02650	COG2133	pyrroloquinoline quinone binding
I6J44_02655	COG2983	Belongs to the UPF0260 family
I6J44_02660	COG5487	UPF0391 membrane protein
I6J44_02675	COG1194	a g-specific adenine glycosylase
I6J44_02690	COG2818	Glycosylase
I6J44_02695	COG1064	alcohol dehydrogenase
I6J44_02700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J44_02715	COG0583	DNA-binding transcription factor activity
I6J44_02720	COG0656	L-ascorbic acid biosynthetic process
I6J44_02725	COG2814	Major facilitator Superfamily
I6J44_02760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J44_02775	COG2233	PERMEase
I6J44_02815	COG0733	neurotransmitter:sodium symporter activity
I6J44_02825	COG0625	glutathione transferase activity
I6J44_02855	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J44_02860	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6J44_02865	COG0596	Alpha beta hydrolase
I6J44_02890	COG0488	(ABC) transporter
I6J44_02905	COG0187	DNA topoisomerase II activity
I6J44_02915	COG0592	DNA-directed DNA polymerase activity
I6J44_02945	COG0706	membrane insertase activity
I6J44_02960	COG1230	cation diffusion facilitator family transporter
I6J44_02965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J44_02980	COG0402	S-adenosylhomocysteine deaminase activity
I6J44_02990	COG0754	glutathionylspermidine amidase activity
I6J44_03000	COG0861	Integral membrane protein TerC family
I6J44_03005	COG0671	phosphoesterase, PA-phosphatase related
I6J44_03015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J44_03030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6J44_03035	COG2951	lytic endotransglycosylase activity
I6J44_03085	COG0657	acetylesterase activity
I6J44_03090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J44_03130	COG1047	Peptidyl-prolyl cis-trans
I6J44_03140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J44_03145	COG0196	riboflavin kinase activity
I6J44_03155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J44_03160	COG1309	transcriptional regulator
I6J44_03165	COG1116	anion transmembrane transporter activity
I6J44_03170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J44_03175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J44_03180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J44_03185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J44_03190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6J44_03190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J44_03205	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_03210	COG0546	phosphoglycolate phosphatase activity
I6J44_03265	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J44_03270	COG0728	peptidoglycan biosynthetic process
I6J44_03300	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J44_03320	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6J44_03330	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6J44_03365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J44_03370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J44_03385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J44_03395	COG2186	Transcriptional regulator
I6J44_03405	COG0277	FAD linked oxidase domain protein
I6J44_03410	COG1448	Aminotransferase
I6J44_03420	COG1802	Transcriptional regulator
I6J44_03435	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J44_03455	COG1051	belongs to the nudix hydrolase family
I6J44_03470	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J44_03490	COG0564	pseudouridine synthase activity
I6J44_03530	COG0251	oxidation-reduction process
I6J44_03535	COG1113	amino acid transport
I6J44_03540	COG1113	amino acid transport
I6J44_03560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J44_03565	COG1960	acyl-CoA dehydrogenase activity
I6J44_03570	COG1024	Enoyl-CoA hydratase
I6J44_03575	COG1024	Enoyl-CoA hydratase
I6J44_03580	COG0477	Major facilitator Superfamily
I6J44_03585	COG0697	spore germination
I6J44_03590	COG1113	amino acid transport
I6J44_03595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J44_03605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J44_03610	COG3916	Acyl-homoserine-lactone synthase
I6J44_03620	COG2197	response regulator
I6J44_03625	COG0318	PFAM AMP-dependent synthetase and ligase
I6J44_03630	COG1960	acyl-CoA dehydrogenase activity
I6J44_03635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J44_03635	COG0318	PFAM AMP-dependent synthetase and ligase
I6J44_03635	COG0300	oxidoreductase activity
I6J44_03635	COG3321	synthase
I6J44_03635	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_03675	COG0271	Belongs to the BolA IbaG family
I6J44_03685	COG1192	Involved in chromosome partitioning
I6J44_03700	COG0586	Pfam SNARE associated Golgi protein
I6J44_03705	COG2259	Doxx family
I6J44_03710	COG4399	Belongs to the UPF0754 family
I6J44_03715	COG0519	Catalyzes the synthesis of GMP from XMP
I6J44_03715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J44_03755	COG0281	malic enzyme
I6J44_03760	COG2837	iron assimilation
I6J44_03765	COG1280	lysine exporter protein (LysE YggA)
I6J44_03770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J44_03775	COG1121	(ABC) transporter
I6J44_03815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J44_03825	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J44_03840	COG0386	Belongs to the glutathione peroxidase family
I6J44_03855	COG1309	transcriptional regulator
I6J44_03860	COG0697	spore germination
I6J44_03870	COG0758	DNA mediated transformation
I6J44_03905	COG1309	transcriptional regulator
I6J44_03935	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J44_03950	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J44_03990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J44_04000	COG2814	Major facilitator Superfamily
I6J44_04010	COG1253	flavin adenine dinucleotide binding
I6J44_04020	COG2860	membrane
I6J44_04025	COG0477	Major facilitator Superfamily
I6J44_04035	COG0318	PFAM AMP-dependent synthetase and ligase
I6J44_04050	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6J44_04070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J44_04075	COG0235	Class ii aldolase
I6J44_04080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J44_04085	COG0431	NADPH-dependent FMN reductase
I6J44_04090	COG0606	chelatase, subunit chli
I6J44_04100	COG0347	Belongs to the P(II) protein family
I6J44_04105	COG0004	ammonium transporteR
I6J44_04115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J44_04115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J44_04155	COG0795	lipopolysaccharide-transporting ATPase activity
I6J44_04160	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6J44_04165	COG0793	Belongs to the peptidase S41A family
I6J44_04180	COG2197	response regulator
I6J44_04190	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J44_04200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J44_04205	COG4974	Belongs to the 'phage' integrase family
I6J44_04230	COG0772	Belongs to the SEDS family
I6J44_04235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J44_04240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6J44_04245	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J44_04250	COG0494	nUDIX hydrolase
I6J44_04270	COG0697	spore germination
I6J44_04280	COG1538	Outer membrane efflux protein
I6J44_04300	COG3275	phosphorelay sensor kinase activity
I6J44_04310	COG0181	hydroxymethylbilane synthase activity
I6J44_04355	COG1716	ATPase activity
I6J44_04360	COG0546	phosphoglycolate phosphatase activity
I6J44_04390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J44_04460	COG2056	Na+-H+ antiporter family
I6J44_04475	COG0326	Molecular chaperone. Has ATPase activity
I6J44_04490	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J44_04555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J44_04560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J44_04560	COG2169	Transcriptional regulator
I6J44_04595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J44_04605	COG0497	DNA recombination
I6J44_04620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J44_04630	COG0237	dephospho-CoA kinase activity
I6J44_04680	COG0195	Participates in both transcription termination and antitermination
I6J44_04690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J44_04695	COG1320	monovalent cation:proton antiporter activity
I6J44_04700	COG2212	antiporter activity
I6J44_04705	COG1863	multisubunit Na H antiporter MnhE subunit
I6J44_04710	COG0651	ATP synthesis coupled electron transport
I6J44_04715	COG1006	Multisubunit Na H antiporter MnhC subunit
I6J44_04720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J44_04720	COG2111	Na H antiporter
I6J44_04735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6J44_04745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J44_04760	COG2226	methyltransferase
I6J44_04780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6J44_04785	COG1074	ATP-dependent DNA helicase activity
I6J44_04790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J44_04795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J44_04805	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J44_04810	COG0598	Magnesium transport protein CorA
I6J44_04815	COG0789	Transcriptional regulator
I6J44_04820	COG0484	heat shock protein binding
I6J44_04830	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6J44_04840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J44_04860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J44_04870	COG4535	Mg2 and Co2 transporter CorC
I6J44_04885	COG0644	oxidoreductase
I6J44_04885	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6J44_04895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J44_04910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J44_04915	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6J44_04925	COG0493	'glutamate synthase
I6J44_04950	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6J44_04965	COG0534	Mate efflux family protein
I6J44_04975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J44_04980	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_04985	COG0583	DNA-binding transcription factor activity
I6J44_05005	COG1530	ribonuclease E activity
I6J44_05015	COG0546	phosphoglycolate phosphatase activity
I6J44_05020	COG2378	regulation of single-species biofilm formation
I6J44_05025	COG0625	glutathione transferase activity
I6J44_05035	COG0583	DNA-binding transcription factor activity
I6J44_05080	COG0583	DNA-binding transcription factor activity
I6J44_05105	COG0473	3-isopropylmalate dehydrogenase activity
I6J44_05160	COG1301	dicarboxylic acid transport
I6J44_05170	COG1560	Kdo2-lipid A biosynthetic process
I6J44_05180	COG0488	(ABC) transporter
I6J44_05185	COG2900	Belongs to the SlyX family
I6J44_05190	COG0604	alcohol dehydrogenase
I6J44_05195	COG1733	regulation of RNA biosynthetic process
I6J44_05220	COG0210	DNA helicase
I6J44_05225	COG0724	RNA recognition motif
I6J44_05245	COG4651	solute:proton antiporter activity
I6J44_05245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J44_05270	COG0788	formyltetrahydrofolate deformylase activity
I6J44_05370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J44_05370	COG2813	Specifically methylates the guanine in position
I6J44_05380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J44_05390	COG4774	siderophore transport
I6J44_05400	COG0740	serine-type endopeptidase activity
I6J44_05420	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J44_05420	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J44_05425	COG0857	belongs to the CobB CobQ family
I6J44_05425	COG0280	phosphate acetyltransferase
I6J44_05430	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J44_05445	COG0800	Aldolase
I6J44_05455	COG3265	gluconokinase activity
I6J44_05460	COG1012	belongs to the aldehyde dehydrogenase family
I6J44_05470	COG2267	carboxylic ester hydrolase activity
I6J44_05485	COG0793	Belongs to the peptidase S41A family
I6J44_05520	COG1426	Protein conserved in bacteria
I6J44_05540	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J44_05560	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J44_05570	COG1162	GTPase activity
I6J44_05575	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6J44_05605	COG0577	efflux transmembrane transporter activity
I6J44_05605	COG1136	(ABC) transporter
I6J44_05610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J44_05630	COG0028	Belongs to the TPP enzyme family
I6J44_05635	COG0440	acetolactate synthase activity
I6J44_05640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J44_05650	COG2826	transposase and inactivated derivatives, IS30 family
I6J44_05665	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6J44_05680	COG0084	hydrolase, TatD family'
I6J44_05690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J44_05700	COG0583	DNA-binding transcription factor activity
I6J44_05715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J44_05800	COG2205	protein histidine kinase activity
I6J44_05815	COG2132	Multicopper oxidase
I6J44_05840	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J44_05875	COG0640	Transcriptional regulator
I6J44_05885	COG0798	PFAM Bile acid sodium symporter
I6J44_05890	COG0431	NADPH-dependent FMN reductase
I6J44_05895	COG0492	ferredoxin-NADP+ reductase activity
I6J44_05900	COG2072	flavoprotein involved in K transport
I6J44_05935	COG2814	Major facilitator Superfamily
I6J44_05945	COG0697	spore germination
I6J44_05975	COG3622	Belongs to the hyi family
I6J44_05980	COG2084	Dehydrogenase
I6J44_05985	COG1024	Enoyl-CoA hydratase
I6J44_05990	COG0784	Response regulator, receiver
I6J44_05990	COG2205	protein histidine kinase activity
I6J44_05990	COG5002	protein histidine kinase activity
I6J44_06010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J44_06015	COG4221	oxidoreductase activity
I6J44_06020	COG3956	TIGRFAM MazG family protein
I6J44_06025	COG1555	photosystem II stabilization
I6J44_06030	COG0617	tRNA 3'-terminal CCA addition
I6J44_06035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J44_06055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J44_06060	COG3028	Belongs to the UPF0307 family
I6J44_06065	COG0318	PFAM AMP-dependent synthetase and ligase
I6J44_06080	COG0625	glutathione transferase activity
I6J44_06085	COG1238	metal cluster binding
I6J44_06100	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J44_06125	COG0072	phenylalanine-tRNA ligase activity
I6J44_06155	COG0248	Ppx GppA phosphatase
I6J44_06165	COG0037	tRNA processing
I6J44_06205	COG1764	response to oxidative stress
I6J44_06210	COG1846	Transcriptional regulator
I6J44_06220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J44_06280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J44_06285	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J44_06290	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J44_06310	COG2826	transposase and inactivated derivatives, IS30 family
I6J44_06355	COG1214	PFAM Peptidase M22, glycoprotease
I6J44_06370	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6J44_06380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J44_06385	COG0561	phosphatase activity
I6J44_06395	COG2132	Multicopper oxidase
I6J44_06415	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J44_06420	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6J44_06425	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J44_06455	COG1063	alcohol dehydrogenase
I6J44_06460	COG0583	DNA-binding transcription factor activity
I6J44_06465	COG1960	acyl-CoA dehydrogenase activity
I6J44_06470	COG2814	Major facilitator Superfamily
I6J44_06475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J44_06485	COG1309	transcriptional regulator
I6J44_06500	COG1053	succinate dehydrogenase
I6J44_06505	COG0583	DNA-binding transcription factor activity
I6J44_06520	COG0583	DNA-binding transcription factor activity
I6J44_06575	COG0583	DNA-binding transcription factor activity
I6J44_06590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J44_06650	COG2826	transposase and inactivated derivatives, IS30 family
I6J44_06660	COG0110	maltose O-acetyltransferase activity
I6J44_06700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J44_06715	COG0745	RESPONSE REGULATOR receiver
I6J44_06730	COG2199	diguanylate cyclase activity
I6J44_06755	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6J44_06785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J44_06790	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J44_06810	COG0583	DNA-binding transcription factor activity
I6J44_06830	COG0668	transmembrane transport
I6J44_06840	COG2081	HI0933 family
I6J44_06845	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6J44_06880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J44_06880	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J44_06890	COG0489	protein tyrosine kinase activity
I6J44_06940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J44_06950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J44_06965	COG0730	response to heat
I6J44_06975	COG1196	nuclear chromosome segregation
I6J44_06995	COG2223	nitrite transmembrane transporter activity
I6J44_07000	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6J44_07010	COG0596	Alpha beta hydrolase
I6J44_07010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J44_07010	COG2226	methyltransferase
I6J44_07025	COG4106	trans-aconitate 2-methyltransferase activity
I6J44_07040	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J44_07045	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6J44_07050	COG0009	L-threonylcarbamoyladenylate synthase
I6J44_07055	COG3101	peptidyl-lysine hydroxylation
I6J44_07060	COG1399	metal-binding, possibly nucleic acid-binding protein
I6J44_07085	COG1652	LysM domain
I6J44_07090	COG0352	thiamine-phosphate diphosphorylase activity
I6J44_07090	COG0351	phosphomethylpyrimidine kinase
I6J44_07090	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J44_07100	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J44_07130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J44_07160	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6J44_07175	COG0358	DNA primase activity
I6J44_07210	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J44_07230	COG0583	DNA-binding transcription factor activity
I6J44_07235	COG0473	3-isopropylmalate dehydrogenase activity
I6J44_07245	COG0657	acetylesterase activity
I6J44_07250	COG4638	Rieske (2fe-2S)
I6J44_07255	COG1012	belongs to the aldehyde dehydrogenase family
I6J44_07275	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J44_07275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J44_07285	COG1981	membrane
I6J44_07300	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J44_07310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J44_07315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J44_07330	COG0456	acetyltransferase
I6J44_07340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6J44_07345	COG0492	ferredoxin-NADP+ reductase activity
I6J44_07350	COG1674	ftsk spoiiie
I6J44_07355	COG1280	lysine exporter protein (LysE YggA)
I6J44_07370	COG2894	cell division
I6J44_07385	COG0204	Acyl-transferase
I6J44_07390	COG2885	chlorophyll binding
I6J44_07395	COG0210	DNA helicase
I6J44_07405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J44_07420	COG0121	glutamine amidotransferase
I6J44_07435	COG2914	Belongs to the UPF0125 (RnfH) family
I6J44_07440	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J44_07445	COG0735	belongs to the Fur family
I6J44_07470	COG0420	3'-5' exonuclease activity
I6J44_07490	COG1090	epimerase
I6J44_07505	COG2050	protein possibly involved in aromatic compounds catabolism
I6J44_07515	COG2814	Major facilitator Superfamily
I6J44_07520	COG0405	Gamma-glutamyltransferase
I6J44_07530	COG1401	restriction endodeoxyribonuclease activity
I6J44_07575	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6J44_07585	COG2814	Major facilitator Superfamily
I6J44_07590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J44_07640	COG0531	amino acid
I6J44_07645	COG2040	homocysteine
I6J44_07670	COG1309	transcriptional regulator
I6J44_07675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J44_07680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J44_07690	COG1607	acyl-coa hydrolase
I6J44_07700	COG0523	cobalamin synthesis protein
I6J44_07710	COG4681	YaeQ
I6J44_07720	COG2826	transposase and inactivated derivatives, IS30 family
I6J44_07730	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6J44_07735	COG2826	transposase and inactivated derivatives, IS30 family
I6J44_07740	COG2826	transposase and inactivated derivatives, IS30 family
I6J44_07745	COG1649	PFAM Uncharacterised BCR, COG1649
I6J44_07745	COG0726	polysaccharide deacetylase
I6J44_07750	COG1215	transferase activity, transferring glycosyl groups
I6J44_07760	COG1024	Enoyl-CoA hydratase
I6J44_07775	COG1414	Transcriptional regulator
I6J44_07795	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_07805	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J44_07810	COG2271	Major facilitator Superfamily
I6J44_07820	COG2267	carboxylic ester hydrolase activity
I6J44_07825	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_07840	COG0028	Belongs to the TPP enzyme family
I6J44_07850	COG0477	Major facilitator Superfamily
I6J44_07855	COG0242	peptide deformylase activity
I6J44_07860	COG2066	Belongs to the glutaminase family
I6J44_07865	COG2207	Transcriptional regulator
I6J44_07870	COG2223	nitrite transmembrane transporter activity
I6J44_07895	COG0306	phosphate transporter
I6J44_07915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J44_07960	COG4181	ATPase activity
I6J44_07965	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6J44_07995	COG0583	DNA-binding transcription factor activity
I6J44_08000	COG2267	carboxylic ester hydrolase activity
I6J44_08005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J44_08010	COG1773	rubredoxin
I6J44_08060	COG2851	Citrate transporter
I6J44_08065	COG1253	flavin adenine dinucleotide binding
I6J44_08080	COG3015	lipoprotein NlpE involved in copper resistance
I6J44_08105	COG0804	urea catabolic process
I6J44_08115	COG0830	nickel cation binding
I6J44_08130	COG0742	ribosomal rna small subunit methyltransferase
I6J44_08135	COG0768	penicillin binding
I6J44_08160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J44_08165	COG2878	Part of a membrane complex involved in electron transport
I6J44_08170	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J44_08180	COG3384	dioxygenase
I6J44_08195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J44_08235	COG0006	proline dipeptidase activity
I6J44_08240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J44_08245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J44_08255	COG0789	Transcriptional regulator
I6J44_08265	COG1279	arginine transmembrane transporter activity
I6J44_08270	COG0583	DNA-binding transcription factor activity
I6J44_08315	COG0741	lytic transglycosylase activity
I6J44_08315	COG0741	lytic transglycosylase activity
I6J44_08315	COG1388	LysM domain
I6J44_08315	COG1388	LysM domain
I6J44_08320	COG4166	transmembrane transport
I6J44_08325	COG4174	ABC transporter (Permease)
I6J44_08330	COG4239	(ABC) transporter, permease
I6J44_08335	COG4172	Belongs to the ABC transporter superfamily
I6J44_08360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J44_08370	COG4251	negative regulation of phosphorylation
I6J44_08370	COG2203	Gaf domain
I6J44_08370	COG5001	Diguanylate cyclase
I6J44_08370	COG3706	GGDEF domain
I6J44_08380	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J44_08380	COG1902	pentaerythritol trinitrate reductase activity
I6J44_08400	COG4269	membrane
I6J44_08435	COG1113	amino acid transport
I6J44_08445	COG0531	amino acid
I6J44_08465	COG1012	belongs to the aldehyde dehydrogenase family
I6J44_08490	COG2831	hemolysin activation secretion protein
I6J44_08495	COG3210	domain, Protein
I6J44_08515	COG0697	spore germination
I6J44_08520	COG2721	sulfolactate sulfo-lyase activity
I6J44_08525	COG2271	Major facilitator Superfamily
I6J44_08530	COG4948	Mandelate Racemase Muconate Lactonizing
I6J44_08540	COG1012	belongs to the aldehyde dehydrogenase family
I6J44_08545	COG2186	Transcriptional regulator
I6J44_08570	COG1960	acyl-CoA dehydrogenase activity
I6J44_08580	COG1012	belongs to the aldehyde dehydrogenase family
I6J44_08585	COG1024	Enoyl-CoA hydratase
I6J44_08590	COG2814	Major facilitator Superfamily
I6J44_08610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J44_08625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J44_08645	COG1944	ATP diphosphatase activity
I6J44_08675	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J44_08690	COG0583	DNA-binding transcription factor activity
I6J44_08695	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J44_08700	COG2072	flavoprotein involved in K transport
I6J44_08715	COG1309	transcriptional regulator
I6J44_08720	COG1741	Belongs to the pirin family
I6J44_08730	COG2252	PERMEase
I6J44_08735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J44_08740	COG3038	cytochrome b561
I6J44_08750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J44_08760	COG0527	aspartate kinase activity
I6J44_08770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J44_08780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J44_08795	COG0667	Aldo Keto reductase
I6J44_08810	COG1765	OsmC-like protein
I6J44_08825	COG0542	response to heat
I6J44_08860	COG2885	chlorophyll binding
I6J44_08870	COG0625	glutathione transferase activity
I6J44_08890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J44_08910	COG3634	alkyl hydroperoxide reductase activity
I6J44_08935	COG1643	Atp-dependent helicase
I6J44_08950	COG2814	Major facilitator Superfamily
I6J44_08955	COG3135	benzoate transporter
I6J44_08960	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_08965	COG0633	Ferredoxin
I6J44_08965	COG0543	2 iron, 2 sulfur cluster binding
I6J44_08970	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6J44_08975	COG4638	Rieske (2fe-2S)
I6J44_08985	COG0583	DNA-binding transcription factor activity
I6J44_08995	COG2871	sodium ion transport
I6J44_09080	COG1570	exodeoxyribonuclease VII activity
I6J44_09115	COG1280	lysine exporter protein (LysE YggA)
I6J44_09120	COG1560	Kdo2-lipid A biosynthetic process
I6J44_09125	COG1278	Cold shock
I6J44_09150	COG2226	methyltransferase
I6J44_09160	COG2826	transposase and inactivated derivatives, IS30 family
I6J44_09165	COG1309	transcriptional regulator
I6J44_09210	COG0668	transmembrane transport
I6J44_09220	COG2814	Major facilitator Superfamily
I6J44_09395	COG5410	chromosome segregation
I6J44_09530	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6J44_09540	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6J44_09545	COG1137	ATPase activity
I6J44_09550	COG1538	Outer membrane efflux protein
I6J44_09580	COG4122	O-methyltransferase activity
I6J44_09590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6J44_09605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J44_09620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J44_09625	COG0531	amino acid
I6J44_09630	COG1522	sequence-specific DNA binding
I6J44_09655	COG1733	regulation of RNA biosynthetic process
I6J44_09660	COG0753	catalase activity
I6J44_09665	COG3038	cytochrome b561
I6J44_09710	COG3712	iron ion homeostasis
I6J44_09715	COG1595	DNA-templated transcription, initiation
I6J44_09725	COG1051	belongs to the nudix hydrolase family
I6J44_09740	COG1733	regulation of RNA biosynthetic process
I6J44_09745	COG0702	epimerase
I6J44_09800	COG3220	belongs to the UPF0276 family
I6J44_09810	COG1595	DNA-templated transcription, initiation
I6J44_09820	COG0583	DNA-binding transcription factor activity
I6J44_09825	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J44_09845	COG4770	biotin carboxylase activity
I6J44_09850	COG0038	chloride channel
I6J44_09855	COG2831	hemolysin activation secretion protein
I6J44_09865	COG2826	transposase and inactivated derivatives, IS30 family
I6J44_09900	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J44_09905	COG1063	alcohol dehydrogenase
I6J44_09950	COG0666	response to abiotic stimulus
I6J44_09955	COG0590	tRNA wobble adenosine to inosine editing
I6J44_09960	COG2807	transmembrane transport
I6J44_09975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J44_09980	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6J44_09990	COG0789	Transcriptional regulator
I6J44_10005	COG1760	l-serine dehydratase
I6J44_10010	COG1012	belongs to the aldehyde dehydrogenase family
I6J44_10010	COG2030	dehydratase
I6J44_10015	COG3396	Phenylacetate-CoA oxygenase
I6J44_10020	COG3460	Phenylacetate-CoA oxygenase
I6J44_10025	COG3396	Phenylacetate-CoA oxygenase
I6J44_10030	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J44_10035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J44_10040	COG1024	Enoyl-CoA hydratase
I6J44_10045	COG1024	Enoyl-CoA hydratase
I6J44_10050	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J44_10055	COG0183	Belongs to the thiolase family
I6J44_10060	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6J44_10065	COG3327	negative regulation of DNA-templated transcription, initiation
I6J44_10075	COG2050	protein possibly involved in aromatic compounds catabolism
I6J44_10080	COG0583	DNA-binding transcription factor activity
I6J44_10085	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_10115	COG0583	DNA-binding transcription factor activity
I6J44_10125	COG1414	Transcriptional regulator
I6J44_10130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J44_10145	COG1840	ABC-type Fe3 transport system, periplasmic component
I6J44_10150	COG3842	ATPase activity
I6J44_10165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J44_10170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J44_10175	COG2814	Major facilitator Superfamily
I6J44_10180	COG1960	acyl-CoA dehydrogenase activity
I6J44_10195	COG1024	Enoyl-CoA hydratase
I6J44_10205	COG2814	Major facilitator Superfamily
I6J44_10215	COG0183	Belongs to the thiolase family
I6J44_10220	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J44_10225	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_10230	COG1024	Enoyl-CoA hydratase
I6J44_10235	COG1960	acyl-CoA dehydrogenase activity
I6J44_10240	COG2814	Major facilitator Superfamily
I6J44_10245	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J44_10250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J44_10260	COG2814	Major facilitator Superfamily
I6J44_10270	COG1960	acyl-CoA dehydrogenase activity
I6J44_10285	COG0583	DNA-binding transcription factor activity
I6J44_10295	COG4770	biotin carboxylase activity
I6J44_10300	COG1024	Enoyl-CoA hydratase
I6J44_10305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J44_10310	COG1960	acyl-CoA dehydrogenase activity
I6J44_10315	COG1309	transcriptional regulator
I6J44_10320	COG0318	PFAM AMP-dependent synthetase and ligase
I6J44_10335	COG2814	Major facilitator Superfamily
I6J44_10390	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_10410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J44_10430	COG2205	protein histidine kinase activity
I6J44_10430	COG0784	Response regulator, receiver
I6J44_10450	COG0765	amino acid transport
I6J44_10455	COG0765	amino acid transport
I6J44_10465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J44_10470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J44_10485	COG1280	lysine exporter protein (LysE YggA)
I6J44_10490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J44_10495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J44_10500	COG1045	serine acetyltransferase
I6J44_10515	COG0583	DNA-binding transcription factor activity
I6J44_10535	COG0625	glutathione transferase activity
I6J44_10540	COG0625	glutathione transferase activity
I6J44_10545	COG0583	DNA-binding transcription factor activity
I6J44_10555	COG1346	cytolysis
I6J44_10580	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6J44_10585	COG3052	prosthetic group binding
I6J44_10605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J44_10625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J44_10635	COG1294	oxidase, subunit
I6J44_10640	COG1271	oxidase subunit
I6J44_10660	COG0477	Major facilitator Superfamily
I6J44_10670	COG4521	taurine ABC transporter
I6J44_10675	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6J44_10680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J44_10685	COG2175	clavaminate synthase activity
I6J44_10695	COG1953	Uracil, thiamine, allantoin
I6J44_10705	COG0583	DNA-binding transcription factor activity
I6J44_10715	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6J44_10730	COG0640	Transcriptional regulator
I6J44_10740	COG0798	PFAM Bile acid sodium symporter
I6J44_10745	COG0431	NADPH-dependent FMN reductase
I6J44_10750	COG0583	DNA-binding transcription factor activity
I6J44_10765	COG3634	alkyl hydroperoxide reductase activity
I6J44_10800	COG1301	dicarboxylic acid transport
I6J44_10805	COG0436	Aminotransferase
I6J44_10815	COG0386	Belongs to the glutathione peroxidase family
I6J44_10820	COG2207	Transcriptional regulator
I6J44_10820	COG1917	Cupin 2, conserved barrel domain protein
I6J44_10855	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J44_10880	COG0012	GTP binding
I6J44_10885	COG2011	ABC-type metal ion transport system permease component
I6J44_10890	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J44_10900	COG1464	Belongs to the NlpA lipoprotein family
I6J44_10930	COG0765	amino acid transport
I6J44_10935	COG0765	amino acid transport
I6J44_10940	COG1126	abc transporter atp-binding protein
I6J44_10945	COG2826	transposase and inactivated derivatives, IS30 family
I6J44_10955	COG1522	sequence-specific DNA binding
I6J44_10970	COG1309	transcriptional regulator
I6J44_10985	COG0583	DNA-binding transcription factor activity
I6J44_10995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J44_11005	COG0697	spore germination
I6J44_11010	COG0583	DNA-binding transcription factor activity
I6J44_11045	COG3539	Fimbrial protein
I6J44_11050	COG2826	transposase and inactivated derivatives, IS30 family
I6J44_11075	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6J44_11075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J44_11120	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J44_11130	COG2353	YceI-like domain
I6J44_11140	COG3698	Phosphodiester glycosidase
I6J44_11155	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6J44_11160	COG0506	proline dehydrogenase activity
I6J44_11160	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6J44_11160	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6J44_11170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J44_11175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J44_11195	COG1132	(ABC) transporter
I6J44_11200	COG3122	Protein conserved in bacteria
I6J44_11205	COG3619	membrane
I6J44_11215	COG0640	Transcriptional regulator
I6J44_11225	COG2850	peptidyl-arginine hydroxylation
I6J44_11230	COG0424	maF-like protein
I6J44_11255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J44_11265	COG3178	'Phosphotransferase
I6J44_11270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J44_11280	COG1192	Involved in chromosome partitioning
I6J44_11285	COG1475	DNA binding
I6J44_11290	COG0811	peptide transport
I6J44_11300	COG1132	(ABC) transporter
I6J44_11305	COG1663	tetraacyldisaccharide 4'-kinase activity
I6J44_11325	COG0084	hydrolase, TatD family'
I6J44_11390	COG0776	regulation of translation
I6J44_11405	COG2431	L-lysine efflux transmembrane transporter activity
I6J44_11420	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6J44_11425	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J44_11470	COG4166	transmembrane transport
I6J44_11475	COG0339	signal peptide processing
I6J44_11480	COG0601	transmembrane transport
I6J44_11520	COG0702	epimerase
I6J44_11525	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6J44_11545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J44_11575	COG0316	Belongs to the HesB IscA family
I6J44_11580	COG0822	iron-sulfur transferase activity
I6J44_11605	COG0776	regulation of translation
I6J44_11610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J44_11615	COG2207	Transcriptional regulator
I6J44_11620	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J44_11625	COG1960	acyl-CoA dehydrogenase activity
I6J44_11630	COG1960	acyl-CoA dehydrogenase activity
I6J44_11645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J44_11655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J44_11670	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J44_11690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J44_11695	COG0730	response to heat
I6J44_11720	COG4773	Receptor
I6J44_11725	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J44_11785	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J44_11795	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J44_11800	COG0583	DNA-binding transcription factor activity
I6J44_11830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J44_11840	COG0133	tryptophan synthase activity
I6J44_11860	COG3706	GGDEF domain
I6J44_11875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J44_11880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J44_11885	COG0022	dehydrogenase e1 component
I6J44_11890	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J44_11895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J44_11910	COG3781	membrane
I6J44_11930	COG0730	response to heat
I6J44_11945	COG2207	Transcriptional regulator
I6J44_11945	COG3708	Transcriptional regulator
I6J44_11950	COG1733	regulation of RNA biosynthetic process
I6J44_11955	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J44_11965	COG0477	Major facilitator Superfamily
I6J44_11975	COG1027	Aspartate ammonia-lyase
I6J44_11990	COG0583	DNA-binding transcription factor activity
I6J44_11995	COG0583	DNA-binding transcription factor activity
I6J44_12000	COG0183	Belongs to the thiolase family
I6J44_12005	COG2031	fatty acid transporter
I6J44_12020	COG0583	DNA-binding transcription factor activity
I6J44_12060	COG2610	gluconate transmembrane transporter activity
I6J44_12065	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_12070	COG2207	Transcriptional regulator
I6J44_12090	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_12100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J44_12115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J44_12115	COG0543	2 iron, 2 sulfur cluster binding
I6J44_12120	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6J44_12125	COG4638	Rieske (2fe-2S)
I6J44_12135	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6J44_12140	COG4149	molybdate abc transporter
I6J44_12145	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6J44_12150	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_12155	COG3433	isochorismatase activity
I6J44_12155	COG1535	isochorismatase
I6J44_12210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J44_12215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J44_12220	COG0745	RESPONSE REGULATOR receiver
I6J44_12225	COG2205	protein histidine kinase activity
I6J44_12235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J44_12255	COG0753	catalase activity
I6J44_12265	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6J44_12290	COG3539	Fimbrial protein
I6J44_12300	COG4628	conserved protein (DUF2132)
I6J44_12310	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6J44_12360	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6J44_12410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J44_12420	COG1120	ATPase activity
I6J44_12425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J44_12480	COG3210	domain, Protein
I6J44_12485	COG2831	hemolysin activation secretion protein
I6J44_12500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6J44_12505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J44_12530	COG0583	DNA-binding transcription factor activity
I6J44_12595	COG1309	transcriptional regulator
I6J44_12605	COG0318	PFAM AMP-dependent synthetase and ligase
I6J44_12615	COG1960	acyl-CoA dehydrogenase activity
I6J44_12625	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_12630	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_12635	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_12640	COG0583	DNA-binding transcription factor activity
I6J44_12645	COG1309	transcriptional regulator
I6J44_12685	COG1902	pentaerythritol trinitrate reductase activity
I6J44_12685	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J44_12705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J44_12715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J44_12725	COG2186	Transcriptional regulator
I6J44_12730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J44_12740	COG2233	PERMEase
I6J44_12745	COG2351	hydroxyisourate hydrolase activity
I6J44_12750	COG1012	belongs to the aldehyde dehydrogenase family
I6J44_12770	COG2186	Transcriptional regulator
I6J44_12780	COG0583	DNA-binding transcription factor activity
I6J44_12785	COG4948	Mandelate Racemase Muconate Lactonizing
I6J44_12790	COG4829	muconolactone delta-isomerase
I6J44_12800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J44_12805	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J44_12810	COG0183	Belongs to the thiolase family
I6J44_12815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J44_12820	COG1012	belongs to the aldehyde dehydrogenase family
I6J44_12830	COG3733	amine oxidase
I6J44_12840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J44_12850	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_12860	COG4638	Rieske (2fe-2S)
I6J44_12880	COG0154	amidase activity
I6J44_12890	COG2814	Major facilitator Superfamily
I6J44_12915	COG1960	acyl-CoA dehydrogenase activity
I6J44_12920	COG0583	DNA-binding transcription factor activity
I6J44_12925	COG1414	Transcriptional regulator
I6J44_12940	COG2391	methyltransferase activity
I6J44_12950	COG4993	Dehydrogenase
I6J44_12955	COG3659	wide pore channel activity
I6J44_12960	COG3420	alginic acid biosynthetic process
I6J44_12965	COG0710	3-dehydroquinate dehydratase activity
I6J44_12970	COG3485	protocatechuate 3,4-dioxygenase
I6J44_12975	COG3485	protocatechuate 3,4-dioxygenase
I6J44_12980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J44_12985	COG2271	Major facilitator Superfamily
I6J44_12990	COG0596	Alpha beta hydrolase
I6J44_12995	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J44_13000	COG0183	Belongs to the thiolase family
I6J44_13005	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J44_13010	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J44_13020	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6J44_13025	COG4773	Receptor
I6J44_13035	COG2323	membrane
I6J44_13040	COG0148	phosphopyruvate hydratase activity
I6J44_13080	COG1902	pentaerythritol trinitrate reductase activity
I6J44_13080	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J44_13095	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J44_13105	COG0542	response to heat
I6J44_13110	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6J44_13140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J44_13145	COG0569	domain protein
I6J44_13150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J44_13165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J44_13175	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6J44_13190	COG1294	oxidase, subunit
I6J44_13195	COG4890	Cyd operon protein YbgT
I6J44_13220	COG0552	protein localization to endoplasmic reticulum
I6J44_13245	COG0517	IMP dehydrogenase activity
I6J44_13245	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6J44_13250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J44_13255	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6J44_13265	COG0583	DNA-binding transcription factor activity
I6J44_13270	COG0024	Methionine aminopeptidase
I6J44_13280	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6J44_13300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J44_13300	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J44_13305	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J44_13310	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6J44_13310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J44_13310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J44_13345	COG0659	secondary active sulfate transmembrane transporter activity
I6J44_13360	COG0657	acetylesterase activity
I6J44_13365	COG1113	amino acid transport
I6J44_13375	COG1522	sequence-specific DNA binding
I6J44_13390	COG1011	Hydrolase
I6J44_13395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J44_13405	COG2137	regulation of response to DNA damage stimulus
I6J44_13420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J44_13455	COG0575	Belongs to the CDS family
I6J44_13460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J44_13485	COG3852	Histidine kinase
I6J44_13490	COG2204	response regulator
I6J44_13560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J44_13585	COG0697	spore germination
I6J44_13590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J44_13600	COG0303	'Molybdopterin
I6J44_13605	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J44_13605	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J44_13620	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J44_13625	COG0243	molybdopterin cofactor binding
I6J44_13635	COG0243	molybdopterin cofactor binding
I6J44_13640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J44_13645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J44_13645	COG2146	nitrite reductase [NAD(P)H] activity
I6J44_13660	COG1116	anion transmembrane transporter activity
I6J44_13660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J44_13670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J44_13675	COG2423	ornithine cyclodeaminase activity
I6J44_13680	COG4264	IucA IucC family
I6J44_13690	COG4264	IucA IucC family
I6J44_13715	COG0511	ligase activity, forming carbon-carbon bonds
I6J44_13730	COG2814	Major facilitator Superfamily
I6J44_13755	COG0069	glutamate synthase activity
I6J44_13785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J44_13800	COG1335	isochorismatase
I6J44_13815	COG1454	alcohol dehydrogenase
I6J44_13820	COG0824	Thioesterase
I6J44_13835	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J44_13860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J44_13865	COG2030	dehydratase
I6J44_13870	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_13875	COG0183	Belongs to the thiolase family
I6J44_13885	COG0583	DNA-binding transcription factor activity
I6J44_13890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J44_13900	COG1522	sequence-specific DNA binding
I6J44_13905	COG3135	benzoate transporter
I6J44_13925	COG0589	response to stress
I6J44_13930	COG0488	(ABC) transporter
I6J44_13955	COG2826	transposase and inactivated derivatives, IS30 family
I6J44_13970	COG0583	DNA-binding transcription factor activity
I6J44_13995	COG1733	regulation of RNA biosynthetic process
I6J44_14005	COG3772	lysozyme
I6J44_14055	COG4774	siderophore transport
I6J44_14060	COG4772	TonB-dependent receptor
I6J44_14075	COG1605	Chorismate mutase
I6J44_14115	COG0308	aminopeptidase N
I6J44_14140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J44_14145	COG1454	alcohol dehydrogenase
I6J44_14165	COG0531	amino acid
I6J44_14170	COG4303	Ethanolamine ammonia lyase large subunit
I6J44_14175	COG4302	ethanolamine ammonia-lyase activity
I6J44_14180	COG0519	Catalyzes the synthesis of GMP from XMP
I6J44_14180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J44_14185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J44_14210	COG0697	spore germination
I6J44_14215	COG1923	regulation of RNA biosynthetic process
I6J44_14225	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6J44_14230	COG0802	atpase or kinase
I6J44_14250	COG1187	pseudouridine synthase activity
I6J44_14265	COG0583	DNA-binding transcription factor activity
I6J44_14375	COG2369	cell adhesion
I6J44_14380	COG4383	Mu-like prophage protein gp29
I6J44_14390	COG4373	Mu-like prophage FluMu protein gp28
I6J44_14460	COG3267	Type II secretory pathway component ExeA
I6J44_14460	COG3409	Peptidoglycan-binding domain 1 protein
I6J44_14540	COG2814	Major facilitator Superfamily
I6J44_14545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J44_14575	COG0729	surface antigen
I6J44_14595	COG0174	glutamine synthetase
I6J44_14600	COG0745	RESPONSE REGULATOR receiver
I6J44_14605	COG2205	protein histidine kinase activity
I6J44_14615	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6J44_14620	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6J44_14630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J44_14645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J44_14650	COG1960	acyl-CoA dehydrogenase activity
I6J44_14665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J44_14670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J44_14675	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J44_14690	COG0583	DNA-binding transcription factor activity
I6J44_14705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J44_14715	COG3658	cytochrome
I6J44_14720	COG1215	transferase activity, transferring glycosyl groups
I6J44_14725	COG0726	polysaccharide deacetylase
I6J44_14725	COG1649	PFAM Uncharacterised BCR, COG1649
I6J44_14755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J44_14760	COG1845	cytochrome c oxidase, subunit III
I6J44_14765	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6J44_14790	COG0305	Participates in initiation and elongation during chromosome replication
I6J44_14795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J44_14805	COG1305	Transglutaminase-like
I6J44_14815	COG2308	Evidence 4 Homologs of previously reported genes of
I6J44_14845	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6J44_14855	COG0151	Belongs to the GarS family
I6J44_14865	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J44_14870	COG2011	ABC-type metal ion transport system permease component
I6J44_14875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J44_14885	COG1301	dicarboxylic acid transport
I6J44_14915	COG1794	racemase activity, acting on amino acids and derivatives
I6J44_14930	COG0745	RESPONSE REGULATOR receiver
I6J44_14935	COG0642	Histidine kinase
I6J44_14940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J44_14950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J44_14990	COG2351	hydroxyisourate hydrolase activity
I6J44_15000	COG3008	intermembrane lipid transfer
I6J44_15000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J44_15005	COG2995	paraquat-inducible protein a
I6J44_15030	COG1309	transcriptional regulator
I6J44_15085	COG0475	glutathione-regulated potassium exporter activity
I6J44_15085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J44_15090	COG0786	glutamate:sodium symporter activity
I6J44_15095	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6J44_15110	COG1278	Cold shock
I6J44_15165	COG1610	YqeY-like protein
I6J44_15170	COG4783	chaperone-mediated protein folding
I6J44_15195	COG1286	toxin biosynthetic process
I6J44_15225	COG0778	Nitroreductase
I6J44_15235	COG0513	Belongs to the DEAD box helicase family
I6J44_15255	COG2363	Small membrane protein
I6J44_15285	COG4650	regulator
I6J44_15290	COG1234	tRNA 3'-trailer cleavage
I6J44_15295	COG1690	Belongs to the RtcB family
I6J44_15315	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J44_15320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J44_15330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J44_15345	COG1960	acyl-CoA dehydrogenase activity
I6J44_15350	COG1301	dicarboxylic acid transport
I6J44_15355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J44_15360	COG3139	Protein of unknown function (DUF1315)
I6J44_15365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J44_15370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J44_15380	COG0494	nUDIX hydrolase
I6J44_15390	COG0642	Histidine kinase
I6J44_15405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J44_15415	COG1720	tRNA m6t6A37 methyltransferase activity
I6J44_15425	COG0384	phenazine biosynthesis protein PhzF
I6J44_15430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J44_15435	COG0826	peptidase U32
I6J44_15440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J44_15450	COG4598	ABC transporter
I6J44_15455	COG4160	amino acid transport
I6J44_15460	COG4215	(ABC) transporter
I6J44_15465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J44_15475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J44_15610	COG3646	Phage regulatory protein
I6J44_15855	COG0582	viral genome integration into host DNA
I6J44_15860	COG1131	(ABC) transporter
I6J44_15865	COG0842	Transport permease protein
I6J44_15880	COG0772	Belongs to the SEDS family
I6J44_15885	COG2951	lytic endotransglycosylase activity
I6J44_15925	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J44_15930	COG0024	Methionine aminopeptidase
I6J44_15940	COG2223	nitrite transmembrane transporter activity
I6J44_15950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J44_15955	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J44_15960	COG1960	acyl-CoA dehydrogenase activity
I6J44_15975	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J44_15980	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J44_15985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J44_16005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J44_16010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J44_16015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J44_16050	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6J44_16060	COG0174	glutamine synthetase
I6J44_16075	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J44_16110	COG2840	Smr protein MutS2
I6J44_16120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J44_16130	COG0302	gtp cyclohydrolase
I6J44_16150	COG3739	integral membrane protein
I6J44_16165	COG1169	isochorismate synthase
I6J44_16170	COG2977	Belongs to the P-Pant transferase superfamily
I6J44_16175	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6J44_16180	COG1132	(ABC) transporter
I6J44_16185	COG1132	(ABC) transporter
I6J44_16195	COG3433	isochorismatase activity
I6J44_16195	COG1535	isochorismatase
I6J44_16200	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J44_16205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J44_16215	COG4774	siderophore transport
I6J44_16220	COG4607	ABC-type enterochelin transport system periplasmic component
I6J44_16225	COG4604	ABC transporter, ATP-binding protein
I6J44_16230	COG4605	iron ion homeostasis
I6J44_16235	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J44_16240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J44_16255	COG1741	Belongs to the pirin family
I6J44_16290	COG2879	small protein
I6J44_16295	COG1966	Carbon starvation protein
I6J44_16300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J44_16340	COG1067	ATP-dependent peptidase activity
I6J44_16345	COG0583	DNA-binding transcription factor activity
I6J44_16370	COG1686	Belongs to the peptidase S11 family
I6J44_16375	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J44_16410	COG0616	signal peptide processing
I6J44_16415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J44_16425	COG0573	inorganic phosphate transmembrane transporter activity
I6J44_16430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J44_16435	COG1113	amino acid transport
I6J44_16440	COG3961	Belongs to the TPP enzyme family
I6J44_16445	COG1522	sequence-specific DNA binding
I6J44_16455	COG0076	glutamate decarboxylase activity
I6J44_16460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J44_16475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J44_16510	COG0352	thiamine-phosphate diphosphorylase activity
I6J44_16535	COG0612	Peptidase, M16
I6J44_16545	COG1823	symporter activity
I6J44_16550	COG0583	DNA-binding transcription factor activity
I6J44_16555	COG0477	Major facilitator Superfamily
I6J44_16570	COG1187	pseudouridine synthase activity
I6J44_16585	COG1686	Belongs to the peptidase S11 family
I6J44_16590	COG1252	NADH dehydrogenase
I6J44_16600	COG0415	Belongs to the DNA photolyase family
I6J44_16615	COG1215	transferase activity, transferring glycosyl groups
I6J44_16630	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J44_16645	COG2070	2-Nitropropane dioxygenase
I6J44_16690	COG2962	Rard protein
I6J44_16700	COG0556	nucleotide-excision repair
I6J44_16720	COG0436	Aminotransferase
I6J44_16750	COG4221	oxidoreductase activity
I6J44_16760	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6J44_16775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J44_16780	COG0571	ribonuclease III activity
I6J44_16790	COG0681	Belongs to the peptidase S26 family
I6J44_16795	COG0481	GTPase activity
I6J44_16805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J44_16825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J44_16830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J44_16835	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6J44_16845	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6J44_16850	COG4208	sulfate ABC transporter
I6J44_16855	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6J44_16860	COG0583	DNA-binding transcription factor activity
I6J44_16865	COG4625	pathogenesis
I6J44_16880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6J44_16895	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6J44_16910	COG1051	belongs to the nudix hydrolase family
I6J44_16910	COG1056	cytidyltransferase-related domain
I6J44_16915	COG1024	Enoyl-CoA hydratase
I6J44_16920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J44_16925	COG2814	Major facilitator Superfamily
I6J44_16930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J44_16930	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J44_16950	COG1473	amidohydrolase
I6J44_16955	COG0824	Thioesterase
I6J44_16975	COG0823	Involved in the tonB-independent uptake of proteins
I6J44_16995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J44_17030	COG0628	permease
I6J44_17040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J44_17045	COG0596	Alpha beta hydrolase
I6J44_17050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J44_17050	COG0616	signal peptide processing
I6J44_17060	COG2333	competence protein COMEC
I6J44_17060	COG0658	competence protein
I6J44_17065	COG1136	(ABC) transporter
I6J44_17070	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J44_17100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J44_17130	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6J44_17135	COG1280	lysine exporter protein (LysE YggA)
I6J44_17145	COG0019	diaminopimelate decarboxylase activity
I6J44_17155	COG1113	amino acid transport
I6J44_17160	COG1115	amino acid carrier protein
I6J44_17185	COG3339	Conserved Protein
I6J44_17190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J44_17195	COG0243	molybdopterin cofactor binding
I6J44_17200	COG1929	Belongs to the glycerate kinase type-1 family
I6J44_17215	COG0778	Nitroreductase
I6J44_17220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J44_17225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J44_17260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J44_17280	COG0741	lytic transglycosylase activity
I6J44_17300	COG0584	glycerophosphoryl diester phosphodiesterase
I6J44_17305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J44_17315	COG0582	viral genome integration into host DNA
I6J44_17640	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J44_17645	COG1597	lipid kinase activity
I6J44_17660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J44_17665	COG0477	Major facilitator Superfamily
I6J44_17675	COG2264	protein methyltransferase activity
I6J44_17715	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J44_17720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J44_17750	COG0505	Belongs to the CarA family
I6J44_17765	COG1309	transcriptional regulator
I6J44_17770	COG0251	oxidation-reduction process
I6J44_17780	COG0589	response to stress
I6J44_17800	COG2843	Capsule synthesis protein
I6J44_17820	COG2321	neutral zinc metallopeptidase
I6J44_17825	COG2354	Protein conserved in bacteria
I6J44_17845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J44_17870	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J44_17875	COG1053	succinate dehydrogenase
I6J44_17880	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6J44_17885	COG2009	succinate dehydrogenase
I6J44_17925	COG2921	Belongs to the UPF0250 family
I6J44_17930	COG0321	lipoyl(octanoyl) transferase activity
I6J44_17945	COG0531	amino acid
I6J44_17980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6J44_17985	COG1648	precorrin-2 dehydrogenase activity
I6J44_17985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J44_18000	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6J44_18025	COG0671	phosphoesterase, PA-phosphatase related
I6J44_18030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J44_18040	COG1538	Outer membrane efflux protein
I6J44_18045	COG0393	Putative heavy-metal-binding
I6J44_18050	COG0393	Putative heavy-metal-binding
I6J44_18060	COG1028	Short-chain dehydrogenase reductase Sdr
I6J44_18070	COG0525	valine-tRNA ligase activity
I6J44_18095	COG0583	DNA-binding transcription factor activity
I6J44_18100	COG0004	ammonium transporteR
I6J44_18115	COG0642	Histidine kinase
I6J44_18120	COG0745	RESPONSE REGULATOR receiver
I6J44_18125	COG2194	sulfuric ester hydrolase activity
I6J44_18150	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J44_18165	COG2315	Protein conserved in bacteria
I6J44_18170	COG0142	geranyltranstransferase activity
I6J44_18175	COG2828	Protein conserved in bacteria
I6J44_18180	COG1113	amino acid transport
I6J44_18190	COG3046	protein related to deoxyribodipyrimidine photolyase
I6J44_18220	COG2207	Transcriptional regulator
I6J44_18245	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J44_18265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J44_18275	COG1530	ribonuclease E activity
I6J44_18280	COG0424	maF-like protein
I6J44_18285	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6J44_18290	COG1792	Involved in formation and maintenance of cell shape
I6J44_18295	COG1077	Cell shape determining protein MreB Mrl
I6J44_18300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J44_18310	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J44_18335	COG3590	peptidase
I6J44_18340	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6J44_18345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J44_18350	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J44_18355	COG1115	amino acid carrier protein
I6J44_18375	COG2814	Major facilitator Superfamily
I6J44_18380	COG1289	transmembrane transporter activity
I6J44_18390	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J44_18430	COG1376	ErfK ybiS ycfS ynhG family protein
I6J44_18435	COG2832	Protein of unknown function (DUF454)
I6J44_18445	COG5510	response to toxic substance
I6J44_18465	COG0840	transmembrane signaling receptor activity
I6J44_18505	COG3422	double-strand break repair
I6J44_18510	COG2824	Alkylphosphonate utilization operon protein PhnA
I6J44_18515	COG3189	MarR family transcriptional regulator
I6J44_18520	COG0596	Alpha beta hydrolase
I6J44_18525	COG0778	Nitroreductase
I6J44_18530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J44_18535	COG1335	isochorismatase
I6J44_18540	COG0251	oxidation-reduction process
I6J44_18545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J44_18550	COG2233	PERMEase
I6J44_18570	COG0354	folic acid binding
I6J44_18575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J44_18585	COG0679	Auxin Efflux Carrier
I6J44_18590	COG1902	pentaerythritol trinitrate reductase activity
I6J44_18595	COG4772	TonB-dependent receptor
I6J44_18600	COG2094	Belongs to the DNA glycosylase MPG family
I6J44_18625	COG1217	gtp-binding protein TYPA
I6J44_18630	COG2233	PERMEase
I6J44_18640	COG0833	amino acid
I6J44_18645	COG1690	Belongs to the RtcB family
I6J44_18655	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J44_18655	COG2885	chlorophyll binding
I6J44_18665	COG0183	Belongs to the thiolase family
I6J44_18685	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J44_18705	COG2207	Transcriptional regulator
I6J44_18710	COG0183	Belongs to the thiolase family
I6J44_18730	COG2153	protein acetylation
I6J44_18740	COG1272	protein, Hemolysin III
I6J44_18745	COG0477	Major facilitator Superfamily
I6J44_18760	COG0450	alkyl hydroperoxide reductase
I6J44_18780	COG0285	dihydrofolate synthase activity
I6J44_18825	COG4206	TonB-dependent receptor
I6J44_18830	COG2096	Adenosyltransferase
I6J44_18850	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6J44_18860	COG0745	RESPONSE REGULATOR receiver
I6J44_18865	COG2205	protein histidine kinase activity
I6J44_18875	COG1960	acyl-CoA dehydrogenase activity
I6J44_18880	COG1960	acyl-CoA dehydrogenase activity
I6J44_18885	COG0583	DNA-binding transcription factor activity
I6J44_18890	COG0625	glutathione transferase activity
I6J44_18940	COG1216	Glycosyl transferase, family 2
I6J44_18955	COG0726	polysaccharide deacetylase
I6J44_18970	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J44_18975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J44_18975	COG2198	Histidine kinase
I6J44_18975	COG2205	protein histidine kinase activity
I6J44_18975	COG0784	Response regulator, receiver
I6J44_19010	COG1862	Preprotein translocase
I6J44_19020	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J44_19025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J44_19035	COG3781	membrane
I6J44_19050	COG2350	Protein conserved in bacteria
I6J44_19150	COG1979	alcohol dehydrogenase
I6J44_19165	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6J44_19195	COG0477	Major facilitator Superfamily
I6J44_19200	COG0697	spore germination
I6J44_19210	COG3321	synthase
I6J44_19210	COG0604	alcohol dehydrogenase
I6J44_19215	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6J44_19220	COG0583	DNA-binding transcription factor activity
I6J44_19225	COG4221	oxidoreductase activity
I6J44_19260	COG3077	Addiction module antitoxin, RelB DinJ family
I6J44_19275	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6J44_19300	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6J44_19330	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6J44_19330	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6J44_19380	COG2184	nucleotidyltransferase activity
I6J44_19415	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
I6J44_19520	COG1785	Belongs to the alkaline phosphatase family
I6J44_19525	COG1475	DNA binding
I6J44_19530	COG1192	Involved in chromosome partitioning
I6J44_19555	COG0604	alcohol dehydrogenase
I6J44_19580	COG0582	viral genome integration into host DNA
I6J44_19595	COG2130	NADP-dependent
I6J44_19600	COG1309	transcriptional regulator
I6J44_19610	COG1902	pentaerythritol trinitrate reductase activity