locus-tag	class	description
I6J46_00030	COG0824	Thioesterase
I6J46_00050	COG0823	Involved in the tonB-independent uptake of proteins
I6J46_00070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J46_00105	COG0628	permease
I6J46_00115	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J46_00120	COG0596	Alpha beta hydrolase
I6J46_00125	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J46_00125	COG0616	signal peptide processing
I6J46_00135	COG0658	competence protein
I6J46_00135	COG2333	competence protein COMEC
I6J46_00140	COG1136	(ABC) transporter
I6J46_00145	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J46_00175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J46_00205	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6J46_00210	COG1280	lysine exporter protein (LysE YggA)
I6J46_00220	COG0019	diaminopimelate decarboxylase activity
I6J46_00230	COG1113	amino acid transport
I6J46_00235	COG1115	amino acid carrier protein
I6J46_00260	COG3339	Conserved Protein
I6J46_00265	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J46_00270	COG0243	molybdopterin cofactor binding
I6J46_00275	COG1929	Belongs to the glycerate kinase type-1 family
I6J46_00290	COG0778	Nitroreductase
I6J46_00295	COG0745	RESPONSE REGULATOR receiver
I6J46_00300	COG2205	protein histidine kinase activity
I6J46_00325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J46_00345	COG0741	lytic transglycosylase activity
I6J46_00365	COG0584	glycerophosphoryl diester phosphodiesterase
I6J46_00395	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J46_00400	COG1597	lipid kinase activity
I6J46_00415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J46_00420	COG0477	Major facilitator Superfamily
I6J46_00470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J46_00475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J46_00505	COG0505	Belongs to the CarA family
I6J46_00520	COG1309	transcriptional regulator
I6J46_00525	COG0251	oxidation-reduction process
I6J46_00535	COG0589	response to stress
I6J46_00555	COG2843	Capsule synthesis protein
I6J46_00575	COG2321	neutral zinc metallopeptidase
I6J46_00580	COG2354	Protein conserved in bacteria
I6J46_00600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J46_00625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J46_00630	COG1053	succinate dehydrogenase
I6J46_00635	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6J46_00640	COG2009	succinate dehydrogenase
I6J46_00680	COG2921	Belongs to the UPF0250 family
I6J46_00685	COG0321	lipoyl(octanoyl) transferase activity
I6J46_00700	COG0531	amino acid
I6J46_00735	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6J46_00740	COG1648	precorrin-2 dehydrogenase activity
I6J46_00740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J46_00755	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6J46_00780	COG0671	phosphoesterase, PA-phosphatase related
I6J46_00785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J46_00795	COG1538	Outer membrane efflux protein
I6J46_00800	COG0393	Putative heavy-metal-binding
I6J46_00805	COG0393	Putative heavy-metal-binding
I6J46_00815	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_00825	COG0525	valine-tRNA ligase activity
I6J46_00845	COG0583	DNA-binding transcription factor activity
I6J46_00850	COG0004	ammonium transporteR
I6J46_00865	COG0642	Histidine kinase
I6J46_00870	COG0745	RESPONSE REGULATOR receiver
I6J46_00875	COG2194	sulfuric ester hydrolase activity
I6J46_00900	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J46_00915	COG2315	Protein conserved in bacteria
I6J46_00920	COG0142	geranyltranstransferase activity
I6J46_00925	COG2828	Protein conserved in bacteria
I6J46_00930	COG1113	amino acid transport
I6J46_00955	COG2207	Transcriptional regulator
I6J46_00980	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J46_01000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J46_01010	COG1530	ribonuclease E activity
I6J46_01015	COG0424	maF-like protein
I6J46_01020	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6J46_01025	COG1792	Involved in formation and maintenance of cell shape
I6J46_01030	COG1077	Cell shape determining protein MreB Mrl
I6J46_01035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J46_01045	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J46_01070	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6J46_01075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J46_01080	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J46_01085	COG1115	amino acid carrier protein
I6J46_01105	COG2814	Major facilitator Superfamily
I6J46_01110	COG1289	transmembrane transporter activity
I6J46_01120	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J46_01160	COG1376	ErfK ybiS ycfS ynhG family protein
I6J46_01165	COG2832	Protein of unknown function (DUF454)
I6J46_01175	COG5510	response to toxic substance
I6J46_01200	COG0840	transmembrane signaling receptor activity
I6J46_01240	COG3422	double-strand break repair
I6J46_01245	COG2824	Alkylphosphonate utilization operon protein PhnA
I6J46_01250	COG3189	MarR family transcriptional regulator
I6J46_01255	COG0596	Alpha beta hydrolase
I6J46_01260	COG0778	Nitroreductase
I6J46_01265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J46_01270	COG1335	isochorismatase
I6J46_01275	COG0251	oxidation-reduction process
I6J46_01280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J46_01285	COG2233	PERMEase
I6J46_01305	COG0354	folic acid binding
I6J46_01310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J46_01320	COG0679	Auxin Efflux Carrier
I6J46_01325	COG1902	pentaerythritol trinitrate reductase activity
I6J46_01330	COG4772	TonB-dependent receptor
I6J46_01335	COG2094	Belongs to the DNA glycosylase MPG family
I6J46_01350	COG4580	involved in the transport of maltose and maltodextrins
I6J46_01365	COG1217	gtp-binding protein TYPA
I6J46_01370	COG2233	PERMEase
I6J46_01380	COG0833	amino acid
I6J46_01385	COG1690	Belongs to the RtcB family
I6J46_01395	COG2885	chlorophyll binding
I6J46_01395	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J46_01405	COG0183	Belongs to the thiolase family
I6J46_01425	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J46_01445	COG2207	Transcriptional regulator
I6J46_01450	COG0183	Belongs to the thiolase family
I6J46_01470	COG2153	protein acetylation
I6J46_01480	COG1272	protein, Hemolysin III
I6J46_01485	COG0477	Major facilitator Superfamily
I6J46_01500	COG0450	alkyl hydroperoxide reductase
I6J46_01520	COG0285	dihydrofolate synthase activity
I6J46_01570	COG2096	Adenosyltransferase
I6J46_01590	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6J46_01600	COG0745	RESPONSE REGULATOR receiver
I6J46_01605	COG2205	protein histidine kinase activity
I6J46_01615	COG1960	acyl-CoA dehydrogenase activity
I6J46_01620	COG1960	acyl-CoA dehydrogenase activity
I6J46_01625	COG0583	DNA-binding transcription factor activity
I6J46_01630	COG0625	glutathione transferase activity
I6J46_01695	COG0438	transferase activity, transferring glycosyl groups
I6J46_01700	COG0463	Glycosyl transferase, family 2
I6J46_01705	COG0726	polysaccharide deacetylase
I6J46_01725	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J46_01730	COG0784	Response regulator, receiver
I6J46_01730	COG2198	Histidine kinase
I6J46_01730	COG2205	protein histidine kinase activity
I6J46_01730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J46_01765	COG1862	Preprotein translocase
I6J46_01775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J46_01780	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J46_01790	COG3781	membrane
I6J46_01805	COG2350	Protein conserved in bacteria
I6J46_01840	COG1607	acyl-coa hydrolase
I6J46_01865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J46_01910	COG2199	diguanylate cyclase activity
I6J46_01915	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J46_01915	COG2885	chlorophyll binding
I6J46_01920	COG1408	metallophosphoesterase
I6J46_01925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J46_01935	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J46_01955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J46_01960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J46_01965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6J46_01970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J46_01975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J46_01985	COG2969	positive regulation of protein catabolic process
I6J46_02025	COG1960	acyl-CoA dehydrogenase activity
I6J46_02030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J46_02045	COG1309	transcriptional regulator
I6J46_02050	COG1960	acyl-CoA dehydrogenase activity
I6J46_02095	COG1183	phosphatidylcholine synthase activity
I6J46_02100	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6J46_02130	COG0741	lytic transglycosylase activity
I6J46_02130	COG0739	heme binding
I6J46_02130	COG1196	nuclear chromosome segregation
I6J46_02140	COG1702	phosphate starvation-inducible protein PhoH
I6J46_02175	COG1295	ribonuclease BN
I6J46_02180	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J46_02230	COG0557	exoribonuclease II activity
I6J46_02235	COG0339	signal peptide processing
I6J46_02240	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6J46_02270	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6J46_02275	COG1960	acyl-CoA dehydrogenase activity
I6J46_02410	COG0088	Forms part of the polypeptide exit tunnel
I6J46_02415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J46_02430	COG0626	cystathionine gamma-synthase activity
I6J46_02435	COG0433	COG0433 Predicted ATPase
I6J46_02445	COG1017	nitric oxide dioxygenase activity
I6J46_02445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J46_02450	COG1959	2 iron, 2 sulfur cluster binding
I6J46_02465	COG1301	dicarboxylic acid transport
I6J46_02470	COG1946	Acyl-CoA thioesterase
I6J46_02475	COG2937	Belongs to the GPAT DAPAT family
I6J46_02490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J46_02495	COG1040	competence protein
I6J46_02500	COG0494	nUDIX hydrolase
I6J46_02510	COG0598	Magnesium transport protein CorA
I6J46_02520	COG2854	intermembrane phospholipid transfer
I6J46_02530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J46_02535	COG1127	ABC transporter
I6J46_02545	COG0513	Belongs to the DEAD box helicase family
I6J46_02565	COG0408	coproporphyrinogen oxidase activity
I6J46_02580	COG1960	acyl-CoA dehydrogenase activity
I6J46_02590	COG1983	PspC domain protein
I6J46_02595	COG0517	IMP dehydrogenase activity
I6J46_02615	COG0752	glycyl-tRNA synthetase alpha subunit
I6J46_02645	COG0583	DNA-binding transcription factor activity
I6J46_02685	COG1012	belongs to the aldehyde dehydrogenase family
I6J46_02695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J46_02700	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J46_02705	COG0833	amino acid
I6J46_02735	COG1192	Involved in chromosome partitioning
I6J46_02740	COG0628	permease
I6J46_02750	COG1289	transmembrane transporter activity
I6J46_02765	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J46_02770	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6J46_02780	COG0277	FAD linked oxidase domain protein
I6J46_02785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J46_02810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J46_02815	COG5380	lipid catabolic process
I6J46_02825	COG0335	large ribosomal subunit rRNA binding
I6J46_02835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J46_02885	COG0194	GDP metabolic process
I6J46_02900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J46_02920	COG3307	-O-antigen
I6J46_02930	COG4969	Belongs to the N-Me-Phe pilin family
I6J46_02940	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6J46_02945	COG1704	LemA family
I6J46_02955	COG0493	'glutamate synthase
I6J46_02960	COG0067	glutamate synthase
I6J46_02960	COG0070	glutamate synthase
I6J46_02960	COG0069	glutamate synthase activity
I6J46_03010	COG2226	methyltransferase
I6J46_03025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J46_03030	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J46_03075	COG0833	amino acid
I6J46_03155	COG0488	(ABC) transporter
I6J46_03160	COG2873	o-acetylhomoserine
I6J46_03165	COG4221	oxidoreductase activity
I6J46_03170	COG0659	secondary active sulfate transmembrane transporter activity
I6J46_03195	COG0427	acetyl-CoA hydrolase
I6J46_03225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J46_03245	COG1132	(ABC) transporter
I6J46_03270	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J46_03340	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J46_03345	COG1733	regulation of RNA biosynthetic process
I6J46_03375	COG1309	transcriptional regulator
I6J46_03390	COG0667	Aldo Keto reductase
I6J46_03410	COG0583	DNA-binding transcription factor activity
I6J46_03415	COG2814	Major facilitator Superfamily
I6J46_03455	COG1335	isochorismatase
I6J46_03465	COG1012	belongs to the aldehyde dehydrogenase family
I6J46_03470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J46_03480	COG1113	amino acid transport
I6J46_03490	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J46_03505	COG2814	Major facilitator Superfamily
I6J46_03515	COG0351	phosphomethylpyrimidine kinase
I6J46_03515	COG0352	thiamine-phosphate diphosphorylase activity
I6J46_03515	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J46_03520	COG0789	Transcriptional regulator
I6J46_03525	COG0300	oxidoreductase activity
I6J46_03545	COG1309	transcriptional regulator
I6J46_03565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J46_03575	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J46_03580	COG3162	membrane
I6J46_03585	COG0784	Response regulator, receiver
I6J46_03585	COG2198	Histidine kinase
I6J46_03585	COG2205	protein histidine kinase activity
I6J46_03610	COG1522	sequence-specific DNA binding
I6J46_03615	COG1335	isochorismatase
I6J46_03620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J46_03630	COG0668	transmembrane transport
I6J46_03635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J46_03640	COG1519	Transferase
I6J46_03645	COG1902	pentaerythritol trinitrate reductase activity
I6J46_03670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J46_03690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J46_03690	COG0426	domain, Protein
I6J46_03695	COG4774	siderophore transport
I6J46_03700	COG2119	membrane
I6J46_03710	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J46_03720	COG4942	peptidase
I6J46_03735	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J46_03745	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6J46_03765	COG0189	ligase activity
I6J46_03790	COG0708	Exodeoxyribonuclease III
I6J46_03795	COG1393	Belongs to the ArsC family
I6J46_03810	COG3706	GGDEF domain
I6J46_03845	COG2351	hydroxyisourate hydrolase activity
I6J46_03850	COG2233	PERMEase
I6J46_03860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J46_03870	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6J46_03880	COG3150	esterase
I6J46_03915	COG2918	glutathione biosynthetic process
I6J46_03930	COG2733	membrane
I6J46_03935	COG0436	Aminotransferase
I6J46_03940	COG0534	Mate efflux family protein
I6J46_04040	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6J46_04045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6J46_04055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J46_04070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J46_04075	COG0546	phosphoglycolate phosphatase activity
I6J46_04085	COG0010	Belongs to the arginase family
I6J46_04115	COG2188	Transcriptional regulator
I6J46_04125	COG0523	cobalamin synthesis protein
I6J46_04135	COG1113	amino acid transport
I6J46_04145	COG0625	glutathione transferase activity
I6J46_04150	COG0346	lactoylglutathione lyase activity
I6J46_04165	COG1683	Conserved Protein
I6J46_04170	COG0534	Mate efflux family protein
I6J46_04175	COG0385	Bile acid
I6J46_04180	COG1335	isochorismatase
I6J46_04185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J46_04205	COG2116	formate transmembrane transporter activity
I6J46_04210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J46_04215	COG2133	pyrroloquinoline quinone binding
I6J46_04220	COG2983	Belongs to the UPF0260 family
I6J46_04225	COG5487	UPF0391 membrane protein
I6J46_04240	COG1194	a g-specific adenine glycosylase
I6J46_04255	COG2818	Glycosylase
I6J46_04260	COG1064	alcohol dehydrogenase
I6J46_04265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J46_04280	COG0583	DNA-binding transcription factor activity
I6J46_04285	COG0656	L-ascorbic acid biosynthetic process
I6J46_04290	COG2814	Major facilitator Superfamily
I6J46_04325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J46_04340	COG2233	PERMEase
I6J46_04380	COG0733	neurotransmitter:sodium symporter activity
I6J46_04390	COG0625	glutathione transferase activity
I6J46_04420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J46_04425	COG0657	acetylesterase activity
I6J46_04475	COG2951	lytic endotransglycosylase activity
I6J46_04480	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6J46_04495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J46_04505	COG0671	phosphoesterase, PA-phosphatase related
I6J46_04510	COG0861	Integral membrane protein TerC family
I6J46_04520	COG0754	glutathionylspermidine amidase activity
I6J46_04530	COG0402	S-adenosylhomocysteine deaminase activity
I6J46_04545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J46_04550	COG1230	cation diffusion facilitator family transporter
I6J46_04565	COG0706	membrane insertase activity
I6J46_04590	COG0592	DNA-directed DNA polymerase activity
I6J46_04600	COG0187	DNA topoisomerase II activity
I6J46_04615	COG0488	(ABC) transporter
I6J46_04640	COG0596	Alpha beta hydrolase
I6J46_04645	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6J46_04650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J46_04690	COG1047	Peptidyl-prolyl cis-trans
I6J46_04700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J46_04705	COG0196	riboflavin kinase activity
I6J46_04715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J46_04720	COG1309	transcriptional regulator
I6J46_04725	COG1116	anion transmembrane transporter activity
I6J46_04730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J46_04735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J46_04740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J46_04745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J46_04750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J46_04750	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6J46_04765	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_04770	COG0546	phosphoglycolate phosphatase activity
I6J46_04830	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J46_04835	COG0728	peptidoglycan biosynthetic process
I6J46_04865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J46_04890	COG0438	transferase activity, transferring glycosyl groups
I6J46_04905	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J46_04920	COG1216	Glycosyl transferase, family 2
I6J46_04925	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J46_04930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J46_04945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J46_04950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6J46_04960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J46_04970	COG2186	Transcriptional regulator
I6J46_04980	COG0277	FAD linked oxidase domain protein
I6J46_04985	COG1448	Aminotransferase
I6J46_04995	COG1802	Transcriptional regulator
I6J46_05010	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J46_05130	COG0564	pseudouridine synthase activity
I6J46_05170	COG0251	oxidation-reduction process
I6J46_05175	COG1113	amino acid transport
I6J46_05180	COG1113	amino acid transport
I6J46_05200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J46_05205	COG1960	acyl-CoA dehydrogenase activity
I6J46_05210	COG1024	Enoyl-CoA hydratase
I6J46_05215	COG1024	Enoyl-CoA hydratase
I6J46_05220	COG0477	Major facilitator Superfamily
I6J46_05225	COG3916	Acyl-homoserine-lactone synthase
I6J46_05235	COG2197	response regulator
I6J46_05240	COG0318	PFAM AMP-dependent synthetase and ligase
I6J46_05245	COG1960	acyl-CoA dehydrogenase activity
I6J46_05250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J46_05250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J46_05250	COG3321	synthase
I6J46_05250	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6J46_05290	COG0271	Belongs to the BolA IbaG family
I6J46_05300	COG1192	Involved in chromosome partitioning
I6J46_05315	COG0586	Pfam SNARE associated Golgi protein
I6J46_05320	COG2259	Doxx family
I6J46_05325	COG4399	Belongs to the UPF0754 family
I6J46_05330	COG0519	Catalyzes the synthesis of GMP from XMP
I6J46_05330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J46_05370	COG0281	malic enzyme
I6J46_05375	COG2837	iron assimilation
I6J46_05380	COG1280	lysine exporter protein (LysE YggA)
I6J46_05385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J46_05390	COG1121	(ABC) transporter
I6J46_05430	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J46_05440	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J46_05460	COG0386	Belongs to the glutathione peroxidase family
I6J46_05475	COG1309	transcriptional regulator
I6J46_05480	COG0697	spore germination
I6J46_05490	COG0758	DNA mediated transformation
I6J46_05525	COG1309	transcriptional regulator
I6J46_05555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J46_05570	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J46_05610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J46_05620	COG2814	Major facilitator Superfamily
I6J46_05630	COG1253	flavin adenine dinucleotide binding
I6J46_05640	COG2860	membrane
I6J46_05645	COG0477	Major facilitator Superfamily
I6J46_05655	COG0318	PFAM AMP-dependent synthetase and ligase
I6J46_05670	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6J46_05690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J46_05700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J46_05705	COG0431	NADPH-dependent FMN reductase
I6J46_05710	COG0606	chelatase, subunit chli
I6J46_05720	COG0347	Belongs to the P(II) protein family
I6J46_05725	COG0004	ammonium transporteR
I6J46_05735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J46_05735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J46_05775	COG0795	lipopolysaccharide-transporting ATPase activity
I6J46_05780	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6J46_05785	COG0793	Belongs to the peptidase S41A family
I6J46_05800	COG2197	response regulator
I6J46_05810	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J46_05820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J46_05825	COG4974	Belongs to the 'phage' integrase family
I6J46_05850	COG0772	Belongs to the SEDS family
I6J46_05855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J46_05860	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6J46_05865	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J46_05870	COG0494	nUDIX hydrolase
I6J46_05890	COG0697	spore germination
I6J46_05900	COG1538	Outer membrane efflux protein
I6J46_05920	COG3275	phosphorelay sensor kinase activity
I6J46_05930	COG0181	hydroxymethylbilane synthase activity
I6J46_05975	COG1716	ATPase activity
I6J46_05980	COG0546	phosphoglycolate phosphatase activity
I6J46_06010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J46_06080	COG2056	Na+-H+ antiporter family
I6J46_06095	COG0326	Molecular chaperone. Has ATPase activity
I6J46_06110	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J46_06180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J46_06185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J46_06185	COG2169	Transcriptional regulator
I6J46_06220	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J46_06230	COG0497	DNA recombination
I6J46_06245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J46_06255	COG0237	dephospho-CoA kinase activity
I6J46_06305	COG0195	Participates in both transcription termination and antitermination
I6J46_06315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J46_06320	COG1320	monovalent cation:proton antiporter activity
I6J46_06325	COG2212	antiporter activity
I6J46_06330	COG1863	multisubunit Na H antiporter MnhE subunit
I6J46_06335	COG0651	ATP synthesis coupled electron transport
I6J46_06340	COG1006	Multisubunit Na H antiporter MnhC subunit
I6J46_06345	COG2111	Na H antiporter
I6J46_06345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J46_06360	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6J46_06375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6J46_06385	COG2226	methyltransferase
I6J46_06405	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6J46_06410	COG1074	ATP-dependent DNA helicase activity
I6J46_06415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J46_06420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J46_06430	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J46_06435	COG0598	Magnesium transport protein CorA
I6J46_06440	COG0789	Transcriptional regulator
I6J46_06445	COG0484	heat shock protein binding
I6J46_06455	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6J46_06465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J46_06485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J46_06495	COG4535	Mg2 and Co2 transporter CorC
I6J46_06510	COG0644	oxidoreductase
I6J46_06510	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6J46_06520	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J46_06535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J46_06540	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6J46_06550	COG0493	'glutamate synthase
I6J46_06575	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6J46_06590	COG0534	Mate efflux family protein
I6J46_06600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J46_06605	COG4221	oxidoreductase activity
I6J46_06610	COG0583	DNA-binding transcription factor activity
I6J46_06625	COG0318	PFAM AMP-dependent synthetase and ligase
I6J46_06630	COG1530	ribonuclease E activity
I6J46_06640	COG0546	phosphoglycolate phosphatase activity
I6J46_06645	COG2378	regulation of single-species biofilm formation
I6J46_06650	COG0625	glutathione transferase activity
I6J46_06660	COG0583	DNA-binding transcription factor activity
I6J46_06700	COG0583	DNA-binding transcription factor activity
I6J46_06725	COG0473	3-isopropylmalate dehydrogenase activity
I6J46_06780	COG1301	dicarboxylic acid transport
I6J46_06790	COG1560	Kdo2-lipid A biosynthetic process
I6J46_06800	COG0488	(ABC) transporter
I6J46_06805	COG2900	Belongs to the SlyX family
I6J46_06810	COG0604	alcohol dehydrogenase
I6J46_06815	COG1733	regulation of RNA biosynthetic process
I6J46_06840	COG0210	DNA helicase
I6J46_06845	COG0724	RNA recognition motif
I6J46_06865	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J46_06865	COG4651	solute:proton antiporter activity
I6J46_06890	COG0788	formyltetrahydrofolate deformylase activity
I6J46_06990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J46_06990	COG2813	Specifically methylates the guanine in position
I6J46_07000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J46_07010	COG4774	siderophore transport
I6J46_07020	COG0740	serine-type endopeptidase activity
I6J46_07040	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J46_07040	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J46_07045	COG0280	phosphate acetyltransferase
I6J46_07045	COG0857	belongs to the CobB CobQ family
I6J46_07050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J46_07065	COG0800	Aldolase
I6J46_07075	COG3265	gluconokinase activity
I6J46_07080	COG1012	belongs to the aldehyde dehydrogenase family
I6J46_07090	COG2267	carboxylic ester hydrolase activity
I6J46_07105	COG0793	Belongs to the peptidase S41A family
I6J46_07140	COG1426	Protein conserved in bacteria
I6J46_07160	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J46_07185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J46_07195	COG0318	PFAM AMP-dependent synthetase and ligase
I6J46_07200	COG1216	Glycosyl transferase, family 2
I6J46_07210	COG2986	histidine ammonia-lyase
I6J46_07250	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_07255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J46_07275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J46_07285	COG1162	GTPase activity
I6J46_07290	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6J46_07310	COG0577	efflux transmembrane transporter activity
I6J46_07310	COG1136	(ABC) transporter
I6J46_07315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J46_07335	COG0028	Belongs to the TPP enzyme family
I6J46_07340	COG0440	acetolactate synthase activity
I6J46_07345	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J46_07365	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6J46_07380	COG0084	hydrolase, TatD family'
I6J46_07390	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J46_07400	COG0583	DNA-binding transcription factor activity
I6J46_07410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J46_07415	COG2814	Major facilitator Superfamily
I6J46_07425	COG0697	spore germination
I6J46_07455	COG3622	Belongs to the hyi family
I6J46_07460	COG2084	Dehydrogenase
I6J46_07465	COG1024	Enoyl-CoA hydratase
I6J46_07470	COG5002	protein histidine kinase activity
I6J46_07470	COG0784	Response regulator, receiver
I6J46_07470	COG2205	protein histidine kinase activity
I6J46_07475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J46_07490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J46_07495	COG4221	oxidoreductase activity
I6J46_07500	COG3956	TIGRFAM MazG family protein
I6J46_07505	COG1555	photosystem II stabilization
I6J46_07510	COG0617	tRNA 3'-terminal CCA addition
I6J46_07515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J46_07535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J46_07540	COG3028	Belongs to the UPF0307 family
I6J46_07545	COG0318	PFAM AMP-dependent synthetase and ligase
I6J46_07560	COG0625	glutathione transferase activity
I6J46_07580	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J46_07600	COG0072	phenylalanine-tRNA ligase activity
I6J46_07630	COG0248	Ppx GppA phosphatase
I6J46_07640	COG0037	tRNA processing
I6J46_07680	COG1764	response to oxidative stress
I6J46_07685	COG1846	Transcriptional regulator
I6J46_07695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J46_07760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J46_07765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J46_07770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J46_07830	COG1214	PFAM Peptidase M22, glycoprotease
I6J46_07845	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6J46_07855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J46_07860	COG0561	phosphatase activity
I6J46_07870	COG2132	Multicopper oxidase
I6J46_07890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J46_07895	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6J46_07900	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J46_07930	COG1063	alcohol dehydrogenase
I6J46_07935	COG0583	DNA-binding transcription factor activity
I6J46_07940	COG1960	acyl-CoA dehydrogenase activity
I6J46_07945	COG2814	Major facilitator Superfamily
I6J46_07950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J46_07955	COG1309	transcriptional regulator
I6J46_07970	COG1053	succinate dehydrogenase
I6J46_07975	COG0583	DNA-binding transcription factor activity
I6J46_07990	COG0583	DNA-binding transcription factor activity
I6J46_08025	COG0583	DNA-binding transcription factor activity
I6J46_08040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J46_08105	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J46_08115	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J46_08130	COG0745	RESPONSE REGULATOR receiver
I6J46_08145	COG2199	diguanylate cyclase activity
I6J46_08170	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6J46_08200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J46_08205	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J46_08225	COG0583	DNA-binding transcription factor activity
I6J46_08245	COG0668	transmembrane transport
I6J46_08255	COG2081	HI0933 family
I6J46_08260	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6J46_08295	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J46_08295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J46_08305	COG0489	protein tyrosine kinase activity
I6J46_08310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J46_08355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J46_08365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J46_08380	COG0730	response to heat
I6J46_08390	COG1196	nuclear chromosome segregation
I6J46_08410	COG2223	nitrite transmembrane transporter activity
I6J46_08415	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6J46_08425	COG0596	Alpha beta hydrolase
I6J46_08425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J46_08425	COG2226	methyltransferase
I6J46_08440	COG4106	trans-aconitate 2-methyltransferase activity
I6J46_08455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J46_08460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6J46_08465	COG0009	L-threonylcarbamoyladenylate synthase
I6J46_08470	COG3101	peptidyl-lysine hydroxylation
I6J46_08475	COG1399	metal-binding, possibly nucleic acid-binding protein
I6J46_08500	COG1652	LysM domain
I6J46_08505	COG0352	thiamine-phosphate diphosphorylase activity
I6J46_08505	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J46_08505	COG0351	phosphomethylpyrimidine kinase
I6J46_08515	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J46_08545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J46_08575	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6J46_08590	COG0358	DNA primase activity
I6J46_08625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J46_08645	COG0583	DNA-binding transcription factor activity
I6J46_08650	COG0473	3-isopropylmalate dehydrogenase activity
I6J46_08660	COG0657	acetylesterase activity
I6J46_08665	COG4638	Rieske (2fe-2S)
I6J46_08670	COG1012	belongs to the aldehyde dehydrogenase family
I6J46_08690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J46_08690	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J46_08700	COG1981	membrane
I6J46_08715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J46_08725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J46_08730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J46_08745	COG0456	acetyltransferase
I6J46_08755	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6J46_08760	COG0492	ferredoxin-NADP+ reductase activity
I6J46_08765	COG1674	ftsk spoiiie
I6J46_08770	COG1280	lysine exporter protein (LysE YggA)
I6J46_08785	COG2894	cell division
I6J46_08800	COG0204	Acyl-transferase
I6J46_08805	COG2885	chlorophyll binding
I6J46_08810	COG0210	DNA helicase
I6J46_08820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J46_08835	COG0121	glutamine amidotransferase
I6J46_08850	COG2914	Belongs to the UPF0125 (RnfH) family
I6J46_08855	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J46_08860	COG0735	belongs to the Fur family
I6J46_08885	COG0420	3'-5' exonuclease activity
I6J46_08905	COG1090	epimerase
I6J46_08920	COG2050	protein possibly involved in aromatic compounds catabolism
I6J46_08930	COG2814	Major facilitator Superfamily
I6J46_08935	COG0405	Gamma-glutamyltransferase
I6J46_09000	COG0477	Major facilitator Superfamily
I6J46_09005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J46_09015	COG1595	DNA-templated transcription, initiation
I6J46_09070	COG0531	amino acid
I6J46_09075	COG2040	homocysteine
I6J46_09100	COG1309	transcriptional regulator
I6J46_09105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J46_09110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J46_09120	COG1607	acyl-coa hydrolase
I6J46_09130	COG0523	cobalamin synthesis protein
I6J46_09140	COG4681	YaeQ
I6J46_09150	COG1649	PFAM Uncharacterised BCR, COG1649
I6J46_09150	COG0726	polysaccharide deacetylase
I6J46_09155	COG1215	transferase activity, transferring glycosyl groups
I6J46_09165	COG1024	Enoyl-CoA hydratase
I6J46_09180	COG1414	Transcriptional regulator
I6J46_09200	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_09215	COG2271	Major facilitator Superfamily
I6J46_09225	COG2267	carboxylic ester hydrolase activity
I6J46_09230	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_09245	COG0028	Belongs to the TPP enzyme family
I6J46_09255	COG0477	Major facilitator Superfamily
I6J46_09260	COG0242	peptide deformylase activity
I6J46_09265	COG2066	Belongs to the glutaminase family
I6J46_09270	COG2207	Transcriptional regulator
I6J46_09275	COG2223	nitrite transmembrane transporter activity
I6J46_09290	COG0583	DNA-binding transcription factor activity
I6J46_09295	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_09300	COG2271	Major facilitator Superfamily
I6J46_09305	COG3959	Transketolase, thiamine diphosphate binding domain
I6J46_09310	COG3958	Transketolase
I6J46_09320	COG0306	phosphate transporter
I6J46_09340	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J46_09385	COG4181	ATPase activity
I6J46_09390	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6J46_09420	COG0583	DNA-binding transcription factor activity
I6J46_09425	COG2267	carboxylic ester hydrolase activity
I6J46_09430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J46_09435	COG1773	rubredoxin
I6J46_09490	COG2851	Citrate transporter
I6J46_09495	COG1253	flavin adenine dinucleotide binding
I6J46_09510	COG3015	lipoprotein NlpE involved in copper resistance
I6J46_09540	COG0804	urea catabolic process
I6J46_09550	COG0830	nickel cation binding
I6J46_09565	COG0742	ribosomal rna small subunit methyltransferase
I6J46_09570	COG0768	penicillin binding
I6J46_09595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J46_09600	COG2878	Part of a membrane complex involved in electron transport
I6J46_09605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J46_09615	COG3384	dioxygenase
I6J46_09630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J46_09670	COG0006	proline dipeptidase activity
I6J46_09675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J46_09680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J46_09690	COG0789	Transcriptional regulator
I6J46_09700	COG1279	arginine transmembrane transporter activity
I6J46_09705	COG0583	DNA-binding transcription factor activity
I6J46_09750	COG1388	LysM domain
I6J46_09750	COG0741	lytic transglycosylase activity
I6J46_09755	COG4166	transmembrane transport
I6J46_09760	COG4174	ABC transporter (Permease)
I6J46_09765	COG4239	(ABC) transporter, permease
I6J46_09770	COG4172	Belongs to the ABC transporter superfamily
I6J46_09790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J46_09800	COG2203	Gaf domain
I6J46_09800	COG4251	negative regulation of phosphorylation
I6J46_09800	COG5001	Diguanylate cyclase
I6J46_09800	COG3706	GGDEF domain
I6J46_09810	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J46_09810	COG1902	pentaerythritol trinitrate reductase activity
I6J46_09910	COG1522	sequence-specific DNA binding
I6J46_09920	COG0251	oxidation-reduction process
I6J46_09925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J46_09930	COG1473	amidohydrolase
I6J46_09935	COG0814	amino acid
I6J46_09940	COG1522	sequence-specific DNA binding
I6J46_09975	COG1522	sequence-specific DNA binding
I6J46_09985	COG1414	Transcriptional regulator
I6J46_09990	COG2851	Citrate transporter
I6J46_10000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J46_10005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J46_10105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J46_10110	COG2272	Belongs to the type-B carboxylesterase lipase family
I6J46_10135	COG4269	membrane
I6J46_10140	COG2801	Transposase and inactivated derivatives
I6J46_10190	COG1113	amino acid transport
I6J46_10200	COG0531	amino acid
I6J46_10220	COG1012	belongs to the aldehyde dehydrogenase family
I6J46_10240	COG1113	amino acid transport
I6J46_10265	COG0697	spore germination
I6J46_10270	COG2721	sulfolactate sulfo-lyase activity
I6J46_10275	COG2271	Major facilitator Superfamily
I6J46_10280	COG4948	Mandelate Racemase Muconate Lactonizing
I6J46_10290	COG1012	belongs to the aldehyde dehydrogenase family
I6J46_10295	COG2186	Transcriptional regulator
I6J46_10320	COG1960	acyl-CoA dehydrogenase activity
I6J46_10330	COG1012	belongs to the aldehyde dehydrogenase family
I6J46_10335	COG1024	Enoyl-CoA hydratase
I6J46_10340	COG2814	Major facilitator Superfamily
I6J46_10355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J46_10370	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J46_10390	COG1944	ATP diphosphatase activity
I6J46_10420	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J46_10425	COG2072	flavoprotein involved in K transport
I6J46_10440	COG1309	transcriptional regulator
I6J46_10445	COG1741	Belongs to the pirin family
I6J46_10455	COG2252	PERMEase
I6J46_10460	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J46_10465	COG3038	cytochrome b561
I6J46_10475	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J46_10485	COG0527	aspartate kinase activity
I6J46_10495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J46_10505	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J46_10520	COG0667	Aldo Keto reductase
I6J46_10535	COG1765	OsmC-like protein
I6J46_10550	COG0542	response to heat
I6J46_10585	COG2885	chlorophyll binding
I6J46_10595	COG0625	glutathione transferase activity
I6J46_10605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J46_10625	COG3634	alkyl hydroperoxide reductase activity
I6J46_10650	COG1643	Atp-dependent helicase
I6J46_10665	COG2814	Major facilitator Superfamily
I6J46_10670	COG3135	benzoate transporter
I6J46_10675	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_10680	COG0633	Ferredoxin
I6J46_10680	COG0543	2 iron, 2 sulfur cluster binding
I6J46_10685	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6J46_10690	COG4638	Rieske (2fe-2S)
I6J46_10700	COG0583	DNA-binding transcription factor activity
I6J46_10710	COG2871	sodium ion transport
I6J46_10795	COG1570	exodeoxyribonuclease VII activity
I6J46_10830	COG1280	lysine exporter protein (LysE YggA)
I6J46_10835	COG1560	Kdo2-lipid A biosynthetic process
I6J46_10840	COG1278	Cold shock
I6J46_10865	COG1011	Hydrolase
I6J46_10870	COG2226	methyltransferase
I6J46_10880	COG1309	transcriptional regulator
I6J46_10925	COG0668	transmembrane transport
I6J46_10935	COG2814	Major facilitator Superfamily
I6J46_10985	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6J46_10995	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6J46_11000	COG1137	ATPase activity
I6J46_11005	COG1538	Outer membrane efflux protein
I6J46_11035	COG4122	O-methyltransferase activity
I6J46_11045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6J46_11060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J46_11075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J46_11080	COG0531	amino acid
I6J46_11085	COG1522	sequence-specific DNA binding
I6J46_11115	COG1733	regulation of RNA biosynthetic process
I6J46_11120	COG0753	catalase activity
I6J46_11125	COG3038	cytochrome b561
I6J46_11175	COG1309	transcriptional regulator
I6J46_11190	COG1733	regulation of RNA biosynthetic process
I6J46_11195	COG0702	epimerase
I6J46_11250	COG3220	belongs to the UPF0276 family
I6J46_11260	COG1595	DNA-templated transcription, initiation
I6J46_11270	COG0583	DNA-binding transcription factor activity
I6J46_11275	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J46_11295	COG4770	biotin carboxylase activity
I6J46_11300	COG0038	chloride channel
I6J46_11375	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J46_11380	COG1063	alcohol dehydrogenase
I6J46_11395	COG0439	Biotin carboxylase
I6J46_11400	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J46_11405	COG1733	regulation of RNA biosynthetic process
I6J46_11415	COG0864	Transcriptional regulator
I6J46_11430	COG1116	anion transmembrane transporter activity
I6J46_11580	COG2885	chlorophyll binding
I6J46_11630	COG0590	tRNA wobble adenosine to inosine editing
I6J46_11635	COG2807	transmembrane transport
I6J46_11650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J46_11655	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6J46_11665	COG0789	Transcriptional regulator
I6J46_11680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J46_11700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J46_11725	COG1012	belongs to the aldehyde dehydrogenase family
I6J46_11730	COG0531	amino acid
I6J46_11735	COG1760	l-serine dehydratase
I6J46_11740	COG1012	belongs to the aldehyde dehydrogenase family
I6J46_11740	COG2030	dehydratase
I6J46_11745	COG3396	Phenylacetate-CoA oxygenase
I6J46_11750	COG3460	Phenylacetate-CoA oxygenase
I6J46_11755	COG3396	Phenylacetate-CoA oxygenase
I6J46_11760	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J46_11765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J46_11770	COG1024	Enoyl-CoA hydratase
I6J46_11775	COG1024	Enoyl-CoA hydratase
I6J46_11780	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J46_11785	COG0183	Belongs to the thiolase family
I6J46_11790	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6J46_11795	COG3327	negative regulation of DNA-templated transcription, initiation
I6J46_11805	COG2050	protein possibly involved in aromatic compounds catabolism
I6J46_11845	COG2267	carboxylic ester hydrolase activity
I6J46_11850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J46_11855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J46_11860	COG1012	belongs to the aldehyde dehydrogenase family
I6J46_11870	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J46_11880	COG1012	belongs to the aldehyde dehydrogenase family
I6J46_11885	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J46_11890	COG0583	DNA-binding transcription factor activity
I6J46_11900	COG1414	Transcriptional regulator
I6J46_11905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J46_11920	COG1840	ABC-type Fe3 transport system, periplasmic component
I6J46_11925	COG3842	ATPase activity
I6J46_11940	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J46_11945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J46_11950	COG2814	Major facilitator Superfamily
I6J46_11955	COG1960	acyl-CoA dehydrogenase activity
I6J46_11970	COG1024	Enoyl-CoA hydratase
I6J46_11980	COG2814	Major facilitator Superfamily
I6J46_11990	COG0183	Belongs to the thiolase family
I6J46_11995	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J46_12000	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_12005	COG1024	Enoyl-CoA hydratase
I6J46_12010	COG1960	acyl-CoA dehydrogenase activity
I6J46_12015	COG2814	Major facilitator Superfamily
I6J46_12020	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J46_12025	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J46_12035	COG2814	Major facilitator Superfamily
I6J46_12045	COG1960	acyl-CoA dehydrogenase activity
I6J46_12060	COG0583	DNA-binding transcription factor activity
I6J46_12070	COG4770	biotin carboxylase activity
I6J46_12075	COG1024	Enoyl-CoA hydratase
I6J46_12080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J46_12085	COG1960	acyl-CoA dehydrogenase activity
I6J46_12090	COG1309	transcriptional regulator
I6J46_12095	COG0318	PFAM AMP-dependent synthetase and ligase
I6J46_12110	COG2814	Major facilitator Superfamily
I6J46_12120	COG0583	DNA-binding transcription factor activity
I6J46_12165	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_12185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J46_12205	COG2205	protein histidine kinase activity
I6J46_12205	COG0784	Response regulator, receiver
I6J46_12215	COG2388	GCN5-related N-acetyl-transferase
I6J46_12225	COG0765	amino acid transport
I6J46_12230	COG0765	amino acid transport
I6J46_12240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J46_12245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J46_12260	COG1280	lysine exporter protein (LysE YggA)
I6J46_12265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J46_12270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J46_12275	COG1045	serine acetyltransferase
I6J46_12285	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_12290	COG0583	DNA-binding transcription factor activity
I6J46_12310	COG0625	glutathione transferase activity
I6J46_12315	COG0625	glutathione transferase activity
I6J46_12320	COG0583	DNA-binding transcription factor activity
I6J46_12330	COG1346	cytolysis
I6J46_12350	COG2814	Major facilitator Superfamily
I6J46_12360	COG0583	DNA-binding transcription factor activity
I6J46_12370	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6J46_12375	COG3052	prosthetic group binding
I6J46_12395	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J46_12415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J46_12425	COG1294	oxidase, subunit
I6J46_12430	COG1271	oxidase subunit
I6J46_12450	COG0477	Major facilitator Superfamily
I6J46_12460	COG4521	taurine ABC transporter
I6J46_12465	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6J46_12470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J46_12475	COG2175	clavaminate synthase activity
I6J46_12485	COG1953	Uracil, thiamine, allantoin
I6J46_12495	COG0583	DNA-binding transcription factor activity
I6J46_12505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6J46_12520	COG0640	Transcriptional regulator
I6J46_12525	COG0798	PFAM Bile acid sodium symporter
I6J46_12530	COG0583	DNA-binding transcription factor activity
I6J46_12545	COG3634	alkyl hydroperoxide reductase activity
I6J46_12580	COG1301	dicarboxylic acid transport
I6J46_12585	COG0436	Aminotransferase
I6J46_12595	COG0386	Belongs to the glutathione peroxidase family
I6J46_12635	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J46_12660	COG0012	GTP binding
I6J46_12665	COG2011	ABC-type metal ion transport system permease component
I6J46_12670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J46_12680	COG1464	Belongs to the NlpA lipoprotein family
I6J46_12710	COG0765	amino acid transport
I6J46_12715	COG0765	amino acid transport
I6J46_12720	COG1126	abc transporter atp-binding protein
I6J46_12730	COG1522	sequence-specific DNA binding
I6J46_12745	COG1309	transcriptional regulator
I6J46_12760	COG0583	DNA-binding transcription factor activity
I6J46_12770	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J46_12780	COG0697	spore germination
I6J46_12785	COG0583	DNA-binding transcription factor activity
I6J46_12815	COG3121	Chaperone
I6J46_12820	COG3539	Fimbrial protein
I6J46_12845	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6J46_12845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J46_12890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J46_12900	COG2353	YceI-like domain
I6J46_12910	COG3698	Phosphodiester glycosidase
I6J46_12925	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6J46_12930	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6J46_12930	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6J46_12930	COG0506	proline dehydrogenase activity
I6J46_12940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J46_12945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J46_12965	COG1132	(ABC) transporter
I6J46_12970	COG3122	Protein conserved in bacteria
I6J46_12975	COG3619	membrane
I6J46_12985	COG0640	Transcriptional regulator
I6J46_12995	COG2850	peptidyl-arginine hydroxylation
I6J46_13000	COG0424	maF-like protein
I6J46_13025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J46_13035	COG3178	'Phosphotransferase
I6J46_13040	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J46_13050	COG1192	Involved in chromosome partitioning
I6J46_13055	COG1475	DNA binding
I6J46_13060	COG0811	peptide transport
I6J46_13070	COG1132	(ABC) transporter
I6J46_13075	COG1663	tetraacyldisaccharide 4'-kinase activity
I6J46_13095	COG0084	hydrolase, TatD family'
I6J46_13160	COG0776	regulation of translation
I6J46_13175	COG2431	L-lysine efflux transmembrane transporter activity
I6J46_13190	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6J46_13195	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J46_13240	COG4166	transmembrane transport
I6J46_13245	COG0339	signal peptide processing
I6J46_13250	COG0601	transmembrane transport
I6J46_13290	COG0702	epimerase
I6J46_13295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6J46_13315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J46_13345	COG0316	Belongs to the HesB IscA family
I6J46_13350	COG0822	iron-sulfur transferase activity
I6J46_13375	COG0776	regulation of translation
I6J46_13380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J46_13385	COG2207	Transcriptional regulator
I6J46_13390	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J46_13395	COG1960	acyl-CoA dehydrogenase activity
I6J46_13400	COG1960	acyl-CoA dehydrogenase activity
I6J46_13415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J46_13425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J46_13440	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J46_13460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J46_13465	COG0730	response to heat
I6J46_13485	COG4773	Receptor
I6J46_13490	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J46_13550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J46_13560	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J46_13565	COG0583	DNA-binding transcription factor activity
I6J46_13595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J46_13605	COG0133	tryptophan synthase activity
I6J46_13625	COG3706	GGDEF domain
I6J46_13640	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J46_13645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J46_13650	COG0022	dehydrogenase e1 component
I6J46_13655	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J46_13660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J46_13670	COG1063	alcohol dehydrogenase
I6J46_13675	COG3781	membrane
I6J46_13695	COG0730	response to heat
I6J46_13710	COG3708	Transcriptional regulator
I6J46_13710	COG2207	Transcriptional regulator
I6J46_13715	COG1733	regulation of RNA biosynthetic process
I6J46_13720	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J46_13730	COG2188	Transcriptional regulator
I6J46_13745	COG4521	taurine ABC transporter
I6J46_13750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J46_13770	COG0477	Major facilitator Superfamily
I6J46_13780	COG1027	Aspartate ammonia-lyase
I6J46_13795	COG0583	DNA-binding transcription factor activity
I6J46_13800	COG0583	DNA-binding transcription factor activity
I6J46_13805	COG0183	Belongs to the thiolase family
I6J46_13810	COG2031	fatty acid transporter
I6J46_13825	COG0583	DNA-binding transcription factor activity
I6J46_13860	COG2610	gluconate transmembrane transporter activity
I6J46_13865	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_13870	COG2207	Transcriptional regulator
I6J46_13890	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_13900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J46_13915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J46_13915	COG0543	2 iron, 2 sulfur cluster binding
I6J46_13920	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6J46_13925	COG4638	Rieske (2fe-2S)
I6J46_13935	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6J46_13940	COG4149	molybdate abc transporter
I6J46_13945	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6J46_13950	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_13955	COG3433	isochorismatase activity
I6J46_13955	COG1535	isochorismatase
I6J46_14010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J46_14015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J46_14020	COG0745	RESPONSE REGULATOR receiver
I6J46_14025	COG2205	protein histidine kinase activity
I6J46_14035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J46_14055	COG0753	catalase activity
I6J46_14065	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6J46_14090	COG3539	Fimbrial protein
I6J46_14140	COG1902	pentaerythritol trinitrate reductase activity
I6J46_14165	COG0300	oxidoreductase activity
I6J46_14170	COG0318	PFAM AMP-dependent synthetase and ligase
I6J46_14195	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_14200	COG4221	oxidoreductase activity
I6J46_14200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J46_14200	COG3321	synthase
I6J46_14200	COG0604	alcohol dehydrogenase
I6J46_14205	COG0667	Aldo Keto reductase
I6J46_14215	COG1902	pentaerythritol trinitrate reductase activity
I6J46_14235	COG0604	alcohol dehydrogenase
I6J46_14240	COG1309	transcriptional regulator
I6J46_14275	COG2831	hemolysin activation secretion protein
I6J46_14285	COG2207	Transcriptional regulator
I6J46_14340	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6J46_14390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J46_14410	COG1120	ATPase activity
I6J46_14415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J46_14430	COG2084	Dehydrogenase
I6J46_14440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J46_14445	COG0583	DNA-binding transcription factor activity
I6J46_14455	COG0129	dihydroxy-acid dehydratase activity
I6J46_14460	COG1012	belongs to the aldehyde dehydrogenase family
I6J46_14485	COG2271	Major facilitator Superfamily
I6J46_14500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J46_14545	COG3210	domain, Protein
I6J46_14550	COG2831	hemolysin activation secretion protein
I6J46_14570	COG0583	DNA-binding transcription factor activity
I6J46_14605	COG0318	PFAM AMP-dependent synthetase and ligase
I6J46_14615	COG1960	acyl-CoA dehydrogenase activity
I6J46_14625	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_14630	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_14635	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_14640	COG0583	DNA-binding transcription factor activity
I6J46_14645	COG1309	transcriptional regulator
I6J46_14680	COG1902	pentaerythritol trinitrate reductase activity
I6J46_14680	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J46_14685	COG1846	Transcriptional regulator
I6J46_14710	COG3829	transcription factor binding
I6J46_14715	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_14720	COG1960	acyl-CoA dehydrogenase activity
I6J46_14735	COG3231	kanamycin kinase activity
I6J46_14755	COG0753	catalase activity
I6J46_14770	COG1012	belongs to the aldehyde dehydrogenase family
I6J46_14785	COG2271	Major facilitator Superfamily
I6J46_14790	COG2197	response regulator
I6J46_14810	COG0277	FAD linked oxidase domain protein
I6J46_14835	COG1012	belongs to the aldehyde dehydrogenase family
I6J46_14855	COG2186	Transcriptional regulator
I6J46_14865	COG0583	DNA-binding transcription factor activity
I6J46_14870	COG4948	Mandelate Racemase Muconate Lactonizing
I6J46_14875	COG4829	muconolactone delta-isomerase
I6J46_14885	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J46_14890	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J46_14895	COG0183	Belongs to the thiolase family
I6J46_14900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J46_14910	COG1012	belongs to the aldehyde dehydrogenase family
I6J46_14920	COG3733	amine oxidase
I6J46_14930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J46_14940	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_14970	COG0154	amidase activity
I6J46_14980	COG2814	Major facilitator Superfamily
I6J46_15005	COG1960	acyl-CoA dehydrogenase activity
I6J46_15010	COG0583	DNA-binding transcription factor activity
I6J46_15015	COG1414	Transcriptional regulator
I6J46_15030	COG2391	methyltransferase activity
I6J46_15040	COG4993	Dehydrogenase
I6J46_15045	COG3659	wide pore channel activity
I6J46_15050	COG3420	alginic acid biosynthetic process
I6J46_15055	COG0710	3-dehydroquinate dehydratase activity
I6J46_15060	COG3485	protocatechuate 3,4-dioxygenase
I6J46_15065	COG3485	protocatechuate 3,4-dioxygenase
I6J46_15070	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J46_15075	COG2271	Major facilitator Superfamily
I6J46_15080	COG0596	Alpha beta hydrolase
I6J46_15085	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J46_15090	COG0183	Belongs to the thiolase family
I6J46_15095	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J46_15100	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J46_15110	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6J46_15115	COG4773	Receptor
I6J46_15125	COG2323	membrane
I6J46_15130	COG0148	phosphopyruvate hydratase activity
I6J46_15170	COG1902	pentaerythritol trinitrate reductase activity
I6J46_15170	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J46_15195	COG0542	response to heat
I6J46_15200	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6J46_15230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J46_15235	COG0569	domain protein
I6J46_15240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J46_15255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J46_15265	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6J46_15280	COG1294	oxidase, subunit
I6J46_15285	COG4890	Cyd operon protein YbgT
I6J46_15310	COG0552	protein localization to endoplasmic reticulum
I6J46_15335	COG0517	IMP dehydrogenase activity
I6J46_15335	COG0516	GMP reductase activity
I6J46_15340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J46_15345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6J46_15355	COG0583	DNA-binding transcription factor activity
I6J46_15360	COG0024	Methionine aminopeptidase
I6J46_15370	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6J46_15390	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J46_15390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J46_15395	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J46_15400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J46_15400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J46_15400	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6J46_15415	COG5001	Diguanylate cyclase
I6J46_15415	COG3300	MHYT domain
I6J46_15435	COG0659	secondary active sulfate transmembrane transporter activity
I6J46_15455	COG1113	amino acid transport
I6J46_15465	COG1522	sequence-specific DNA binding
I6J46_15480	COG1011	Hydrolase
I6J46_15485	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J46_15495	COG2137	regulation of response to DNA damage stimulus
I6J46_15510	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J46_15530	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J46_15545	COG0575	Belongs to the CDS family
I6J46_15550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J46_15575	COG3852	Histidine kinase
I6J46_15580	COG2204	response regulator
I6J46_15630	COG0596	Alpha beta hydrolase
I6J46_15650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J46_15675	COG0697	spore germination
I6J46_15680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J46_15690	COG0303	'Molybdopterin
I6J46_15695	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J46_15695	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J46_15710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J46_15715	COG0243	molybdopterin cofactor binding
I6J46_15725	COG0243	molybdopterin cofactor binding
I6J46_15730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J46_15735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J46_15735	COG2146	nitrite reductase [NAD(P)H] activity
I6J46_15750	COG1116	anion transmembrane transporter activity
I6J46_15750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J46_15760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J46_15765	COG2423	ornithine cyclodeaminase activity
I6J46_15770	COG4264	IucA IucC family
I6J46_15780	COG4264	IucA IucC family
I6J46_15805	COG0511	ligase activity, forming carbon-carbon bonds
I6J46_15820	COG2814	Major facilitator Superfamily
I6J46_15845	COG0069	glutamate synthase activity
I6J46_15875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J46_15900	COG1454	alcohol dehydrogenase
I6J46_15905	COG0824	Thioesterase
I6J46_15920	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J46_15945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J46_15950	COG2030	dehydratase
I6J46_15955	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_15960	COG0183	Belongs to the thiolase family
I6J46_15970	COG0583	DNA-binding transcription factor activity
I6J46_15975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J46_15985	COG1522	sequence-specific DNA binding
I6J46_15990	COG3135	benzoate transporter
I6J46_16010	COG0589	response to stress
I6J46_16015	COG0488	(ABC) transporter
I6J46_16050	COG0583	DNA-binding transcription factor activity
I6J46_16075	COG3772	lysozyme
I6J46_16115	COG4772	TonB-dependent receptor
I6J46_16140	COG2205	protein histidine kinase activity
I6J46_16145	COG2217	Heavy metal translocating P-type atpase
I6J46_16160	COG1605	Chorismate mutase
I6J46_16200	COG0308	aminopeptidase N
I6J46_16225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J46_16230	COG1454	alcohol dehydrogenase
I6J46_16250	COG0531	amino acid
I6J46_16255	COG4303	Ethanolamine ammonia lyase large subunit
I6J46_16260	COG4302	ethanolamine ammonia-lyase activity
I6J46_16265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J46_16265	COG0519	Catalyzes the synthesis of GMP from XMP
I6J46_16270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J46_16280	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J46_16290	COG0697	spore germination
I6J46_16295	COG1923	regulation of RNA biosynthetic process
I6J46_16305	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6J46_16310	COG0802	atpase or kinase
I6J46_16330	COG1187	pseudouridine synthase activity
I6J46_16345	COG0583	DNA-binding transcription factor activity
I6J46_16355	COG2814	Major facilitator Superfamily
I6J46_16360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J46_16390	COG0729	surface antigen
I6J46_16395	COG0477	Major facilitator Superfamily
I6J46_16410	COG0174	glutamine synthetase
I6J46_16415	COG0745	RESPONSE REGULATOR receiver
I6J46_16420	COG2205	protein histidine kinase activity
I6J46_16430	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6J46_16435	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6J46_16445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J46_16460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J46_16465	COG1960	acyl-CoA dehydrogenase activity
I6J46_16480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J46_16485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J46_16490	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J46_16505	COG0583	DNA-binding transcription factor activity
I6J46_16520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J46_16530	COG3658	cytochrome
I6J46_16535	COG1215	transferase activity, transferring glycosyl groups
I6J46_16540	COG0726	polysaccharide deacetylase
I6J46_16540	COG1649	PFAM Uncharacterised BCR, COG1649
I6J46_16570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J46_16575	COG1845	cytochrome c oxidase, subunit III
I6J46_16580	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6J46_16605	COG0305	Participates in initiation and elongation during chromosome replication
I6J46_16610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J46_16620	COG1305	Transglutaminase-like
I6J46_16630	COG2308	Evidence 4 Homologs of previously reported genes of
I6J46_16660	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6J46_16670	COG0151	Belongs to the GarS family
I6J46_16680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J46_16685	COG2011	ABC-type metal ion transport system permease component
I6J46_16690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J46_16700	COG1301	dicarboxylic acid transport
I6J46_16745	COG2855	membrane
I6J46_16760	COG2814	Major facilitator Superfamily
I6J46_16765	COG3246	L-lysine catabolic process to acetate
I6J46_16770	COG2175	clavaminate synthase activity
I6J46_16780	COG1794	racemase activity, acting on amino acids and derivatives
I6J46_16795	COG0745	RESPONSE REGULATOR receiver
I6J46_16800	COG0642	Histidine kinase
I6J46_16805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J46_16815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J46_16855	COG2351	hydroxyisourate hydrolase activity
I6J46_16865	COG3008	intermembrane lipid transfer
I6J46_16865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J46_16870	COG2995	paraquat-inducible protein a
I6J46_16880	COG1309	transcriptional regulator
I6J46_16895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J46_16905	COG2186	Transcriptional regulator
I6J46_16915	COG0475	glutathione-regulated potassium exporter activity
I6J46_16915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J46_16920	COG1609	Transcriptional regulator
I6J46_16925	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J46_16930	COG2610	gluconate transmembrane transporter activity
I6J46_16940	COG1028	Short-chain dehydrogenase reductase Sdr
I6J46_16950	COG0583	DNA-binding transcription factor activity
I6J46_16960	COG0786	glutamate:sodium symporter activity
I6J46_16970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J46_16980	COG0596	Alpha beta hydrolase
I6J46_16995	COG0583	DNA-binding transcription factor activity
I6J46_17000	COG1335	isochorismatase
I6J46_17015	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6J46_17030	COG1278	Cold shock
I6J46_17055	COG2815	serine threonine protein kinase
I6J46_17055	COG0515	serine threonine protein kinase
I6J46_17085	COG1610	YqeY-like protein
I6J46_17090	COG4783	chaperone-mediated protein folding
I6J46_17115	COG1286	toxin biosynthetic process
I6J46_17145	COG0778	Nitroreductase
I6J46_17155	COG0513	Belongs to the DEAD box helicase family
I6J46_17175	COG2363	Small membrane protein
I6J46_17200	COG1234	tRNA 3'-trailer cleavage
I6J46_17205	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J46_17215	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J46_17235	COG1960	acyl-CoA dehydrogenase activity
I6J46_17240	COG1301	dicarboxylic acid transport
I6J46_17245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J46_17250	COG3139	Protein of unknown function (DUF1315)
I6J46_17255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J46_17260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J46_17270	COG0494	nUDIX hydrolase
I6J46_17280	COG0642	Histidine kinase
I6J46_17295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J46_17305	COG1720	tRNA m6t6A37 methyltransferase activity
I6J46_17315	COG0384	phenazine biosynthesis protein PhzF
I6J46_17320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J46_17325	COG0826	peptidase U32
I6J46_17330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J46_17340	COG4598	ABC transporter
I6J46_17345	COG4160	amino acid transport
I6J46_17350	COG4215	(ABC) transporter
I6J46_17355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J46_17365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J46_17410	COG1131	(ABC) transporter
I6J46_17415	COG0842	Transport permease protein
I6J46_17430	COG0772	Belongs to the SEDS family
I6J46_17435	COG2951	lytic endotransglycosylase activity
I6J46_17460	COG2207	Transcriptional regulator
I6J46_17475	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J46_17480	COG0024	Methionine aminopeptidase
I6J46_17490	COG2223	nitrite transmembrane transporter activity
I6J46_17500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J46_17505	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J46_17510	COG1960	acyl-CoA dehydrogenase activity
I6J46_17525	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J46_17530	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J46_17535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J46_17555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J46_17560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J46_17565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J46_17600	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6J46_17610	COG0174	glutamine synthetase
I6J46_17625	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J46_17630	COG0308	aminopeptidase N
I6J46_17650	COG2840	Smr protein MutS2
I6J46_17660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J46_17670	COG0302	gtp cyclohydrolase
I6J46_17690	COG3739	integral membrane protein
I6J46_17705	COG1169	isochorismate synthase
I6J46_17710	COG2977	Belongs to the P-Pant transferase superfamily
I6J46_17715	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6J46_17720	COG1132	(ABC) transporter
I6J46_17725	COG1132	(ABC) transporter
I6J46_17735	COG1535	isochorismatase
I6J46_17735	COG3433	isochorismatase activity
I6J46_17740	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J46_17745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J46_17755	COG4774	siderophore transport
I6J46_17760	COG4607	ABC-type enterochelin transport system periplasmic component
I6J46_17765	COG4604	ABC transporter, ATP-binding protein
I6J46_17770	COG4605	iron ion homeostasis
I6J46_17775	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J46_17780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J46_17795	COG1741	Belongs to the pirin family
I6J46_17825	COG2879	small protein
I6J46_17830	COG1966	Carbon starvation protein
I6J46_17835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J46_17870	COG2211	Major facilitator Superfamily
I6J46_17875	COG1067	ATP-dependent peptidase activity
I6J46_17880	COG0583	DNA-binding transcription factor activity
I6J46_17905	COG1686	Belongs to the peptidase S11 family
I6J46_17910	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J46_17945	COG0616	signal peptide processing
I6J46_17950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J46_17960	COG0573	inorganic phosphate transmembrane transporter activity
I6J46_17965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J46_17970	COG1113	amino acid transport
I6J46_17975	COG3961	Belongs to the TPP enzyme family
I6J46_17980	COG1522	sequence-specific DNA binding
I6J46_17990	COG0076	glutamate decarboxylase activity
I6J46_17995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J46_18010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J46_18045	COG0352	thiamine-phosphate diphosphorylase activity
I6J46_18070	COG0612	Peptidase, M16
I6J46_18080	COG1823	symporter activity
I6J46_18085	COG0583	DNA-binding transcription factor activity
I6J46_18090	COG0477	Major facilitator Superfamily
I6J46_18105	COG1187	pseudouridine synthase activity
I6J46_18120	COG1686	Belongs to the peptidase S11 family
I6J46_18125	COG1252	NADH dehydrogenase
I6J46_18135	COG0415	Belongs to the DNA photolyase family
I6J46_18150	COG1215	transferase activity, transferring glycosyl groups
I6J46_18165	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J46_18180	COG2070	2-Nitropropane dioxygenase
I6J46_18225	COG2962	Rard protein
I6J46_18235	COG0556	nucleotide-excision repair
I6J46_18255	COG0436	Aminotransferase
I6J46_18285	COG4221	oxidoreductase activity
I6J46_18295	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6J46_18300	COG1381	Involved in DNA repair and RecF pathway recombination
I6J46_18310	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J46_18315	COG0571	ribonuclease III activity
I6J46_18325	COG0681	Belongs to the peptidase S26 family
I6J46_18330	COG0481	GTPase activity
I6J46_18340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J46_18360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J46_18365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J46_18370	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6J46_18380	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6J46_18385	COG4208	sulfate ABC transporter
I6J46_18390	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6J46_18395	COG0583	DNA-binding transcription factor activity
I6J46_18400	COG4625	pathogenesis
I6J46_18415	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6J46_18430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6J46_18445	COG1051	belongs to the nudix hydrolase family
I6J46_18445	COG1056	cytidyltransferase-related domain
I6J46_18450	COG1024	Enoyl-CoA hydratase
I6J46_18455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J46_18460	COG2814	Major facilitator Superfamily