locus-tag	class	description
I6L27_00080	COG5434	Belongs to the glycosyl hydrolase 28 family
I6L27_00100	COG0582	viral genome integration into host DNA
I6L27_00115	COG0584	glycerophosphoryl diester phosphodiesterase
I6L27_00135	COG0741	lytic transglycosylase activity
I6L27_00150	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6L27_00155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L27_00180	COG1309	transcriptional regulator
I6L27_00185	COG1902	pentaerythritol trinitrate reductase activity
I6L27_00190	COG0596	Alpha beta hydrolase
I6L27_00190	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L27_00195	COG0596	Alpha beta hydrolase
I6L27_00195	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L27_00200	COG0596	Alpha beta hydrolase
I6L27_00205	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_00210	COG0583	DNA-binding transcription factor activity
I6L27_00215	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6L27_00220	COG1012	belongs to the aldehyde dehydrogenase family
I6L27_00235	COG0778	Nitroreductase
I6L27_00240	COG1929	Belongs to the glycerate kinase type-1 family
I6L27_00245	COG0243	molybdopterin cofactor binding
I6L27_00250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6L27_00255	COG3339	Conserved Protein
I6L27_00280	COG1115	amino acid carrier protein
I6L27_00285	COG1113	amino acid transport
I6L27_00295	COG0019	diaminopimelate decarboxylase activity
I6L27_00305	COG1280	lysine exporter protein (LysE YggA)
I6L27_00310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6L27_00340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L27_00370	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L27_00375	COG1136	(ABC) transporter
I6L27_00380	COG0658	competence protein
I6L27_00380	COG2333	competence protein COMEC
I6L27_00390	COG0616	signal peptide processing
I6L27_00390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L27_00395	COG0596	Alpha beta hydrolase
I6L27_00400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L27_00410	COG0628	permease
I6L27_00445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L27_00465	COG0823	Involved in the tonB-independent uptake of proteins
I6L27_00485	COG0824	Thioesterase
I6L27_00490	COG1473	amidohydrolase
I6L27_00510	COG0047	phosphoribosylformylglycinamidine synthase activity
I6L27_00510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L27_00515	COG2814	Major facilitator Superfamily
I6L27_00520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L27_00525	COG1024	Enoyl-CoA hydratase
I6L27_00530	COG1056	cytidyltransferase-related domain
I6L27_00530	COG1051	belongs to the nudix hydrolase family
I6L27_00555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6L27_00570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6L27_00575	COG0602	queuosine metabolic process
I6L27_00585	COG4625	pathogenesis
I6L27_00590	COG0583	DNA-binding transcription factor activity
I6L27_00595	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L27_00600	COG4208	sulfate ABC transporter
I6L27_00605	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6L27_00615	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L27_00620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L27_00625	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L27_00645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L27_00655	COG0481	GTPase activity
I6L27_00660	COG0681	Belongs to the peptidase S26 family
I6L27_00670	COG0571	ribonuclease III activity
I6L27_00675	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6L27_00685	COG1381	Involved in DNA repair and RecF pathway recombination
I6L27_00690	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6L27_00700	COG4221	oxidoreductase activity
I6L27_00730	COG0436	Aminotransferase
I6L27_00750	COG0556	nucleotide-excision repair
I6L27_00760	COG2962	Rard protein
I6L27_00805	COG2070	2-Nitropropane dioxygenase
I6L27_00820	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6L27_00835	COG1215	transferase activity, transferring glycosyl groups
I6L27_00850	COG0415	Belongs to the DNA photolyase family
I6L27_00860	COG1252	NADH dehydrogenase
I6L27_00865	COG1686	Belongs to the peptidase S11 family
I6L27_00880	COG1187	pseudouridine synthase activity
I6L27_00895	COG0477	Major facilitator Superfamily
I6L27_00900	COG0583	DNA-binding transcription factor activity
I6L27_00905	COG1823	symporter activity
I6L27_00915	COG0612	Peptidase, M16
I6L27_00940	COG0352	thiamine-phosphate diphosphorylase activity
I6L27_00975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L27_01000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L27_01005	COG0076	glutamate decarboxylase activity
I6L27_01015	COG1522	sequence-specific DNA binding
I6L27_01020	COG3961	Belongs to the TPP enzyme family
I6L27_01025	COG1113	amino acid transport
I6L27_01030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6L27_01035	COG0573	inorganic phosphate transmembrane transporter activity
I6L27_01045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L27_01050	COG0616	signal peptide processing
I6L27_01085	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L27_01090	COG1686	Belongs to the peptidase S11 family
I6L27_01115	COG0583	DNA-binding transcription factor activity
I6L27_01120	COG1067	ATP-dependent peptidase activity
I6L27_01160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6L27_01165	COG1966	Carbon starvation protein
I6L27_01170	COG2879	small protein
I6L27_01195	COG0583	DNA-binding transcription factor activity
I6L27_01210	COG1012	belongs to the aldehyde dehydrogenase family
I6L27_01215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L27_01220	COG0723	plastoquinol--plastocyanin reductase activity
I6L27_01220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L27_01255	COG1846	Transcriptional regulator
I6L27_01300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L27_01315	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6L27_01345	COG2423	ornithine cyclodeaminase activity
I6L27_01355	COG2964	Protein conserved in bacteria
I6L27_01360	COG1741	Belongs to the pirin family
I6L27_01375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L27_01380	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L27_01385	COG4605	iron ion homeostasis
I6L27_01390	COG4604	ABC transporter, ATP-binding protein
I6L27_01395	COG4607	ABC-type enterochelin transport system periplasmic component
I6L27_01400	COG4774	siderophore transport
I6L27_01410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L27_01415	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6L27_01420	COG3433	isochorismatase activity
I6L27_01420	COG1535	isochorismatase
I6L27_01430	COG1132	(ABC) transporter
I6L27_01435	COG1132	(ABC) transporter
I6L27_01440	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6L27_01445	COG2977	Belongs to the P-Pant transferase superfamily
I6L27_01450	COG1169	isochorismate synthase
I6L27_01465	COG3739	integral membrane protein
I6L27_01485	COG0302	gtp cyclohydrolase
I6L27_01495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L27_01505	COG2840	Smr protein MutS2
I6L27_01520	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L27_01540	COG0174	glutamine synthetase
I6L27_01550	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6L27_01585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L27_01590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L27_01595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L27_01615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L27_01620	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6L27_01625	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6L27_01640	COG1960	acyl-CoA dehydrogenase activity
I6L27_01645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L27_01650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L27_01660	COG2223	nitrite transmembrane transporter activity
I6L27_01670	COG0024	Methionine aminopeptidase
I6L27_01675	COG0052	Belongs to the universal ribosomal protein uS2 family
I6L27_01690	COG2207	Transcriptional regulator
I6L27_01715	COG2951	lytic endotransglycosylase activity
I6L27_01720	COG0772	Belongs to the SEDS family
I6L27_01735	COG0842	Transport permease protein
I6L27_01740	COG1131	(ABC) transporter
I6L27_01745	COG0582	viral genome integration into host DNA
I6L27_01815	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L27_01985	COG3657	addiction module killer protein
I6L27_02070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L27_02075	COG0583	DNA-binding transcription factor activity
I6L27_02080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L27_02085	COG4215	(ABC) transporter
I6L27_02090	COG4160	amino acid transport
I6L27_02095	COG4598	ABC transporter
I6L27_02105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L27_02110	COG0826	peptidase U32
I6L27_02115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L27_02120	COG0384	phenazine biosynthesis protein PhzF
I6L27_02130	COG1720	tRNA m6t6A37 methyltransferase activity
I6L27_02140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L27_02155	COG0642	Histidine kinase
I6L27_02165	COG0494	nUDIX hydrolase
I6L27_02175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L27_02180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6L27_02185	COG3139	Protein of unknown function (DUF1315)
I6L27_02195	COG1301	dicarboxylic acid transport
I6L27_02200	COG1960	acyl-CoA dehydrogenase activity
I6L27_02220	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6L27_02230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L27_02235	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L27_02255	COG1690	Belongs to the RtcB family
I6L27_02260	COG1234	tRNA 3'-trailer cleavage
I6L27_02265	COG4650	regulator
I6L27_02290	COG2363	Small membrane protein
I6L27_02310	COG0513	Belongs to the DEAD box helicase family
I6L27_02320	COG0778	Nitroreductase
I6L27_02350	COG1286	toxin biosynthetic process
I6L27_02375	COG4783	chaperone-mediated protein folding
I6L27_02380	COG1610	YqeY-like protein
I6L27_02435	COG1278	Cold shock
I6L27_02455	COG2207	Transcriptional regulator
I6L27_02460	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6L27_02465	COG1335	isochorismatase
I6L27_02470	COG0583	DNA-binding transcription factor activity
I6L27_02475	COG0786	glutamate:sodium symporter activity
I6L27_02480	COG0475	glutathione-regulated potassium exporter activity
I6L27_02480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L27_02490	COG1309	transcriptional regulator
I6L27_02500	COG2985	domain, Protein
I6L27_02510	COG2995	paraquat-inducible protein a
I6L27_02515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L27_02515	COG3008	intermembrane lipid transfer
I6L27_02525	COG2351	hydroxyisourate hydrolase activity
I6L27_02540	COG5002	protein histidine kinase activity
I6L27_02565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L27_02575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L27_02580	COG0642	Histidine kinase
I6L27_02585	COG0745	RESPONSE REGULATOR receiver
I6L27_02600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6L27_02605	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6L27_02610	COG1794	racemase activity, acting on amino acids and derivatives
I6L27_02620	COG2175	clavaminate synthase activity
I6L27_02625	COG3246	L-lysine catabolic process to acetate
I6L27_02630	COG2814	Major facilitator Superfamily
I6L27_02645	COG2855	membrane
I6L27_02680	COG2814	Major facilitator Superfamily
I6L27_02705	COG1301	dicarboxylic acid transport
I6L27_02715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L27_02720	COG2011	ABC-type metal ion transport system permease component
I6L27_02725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L27_02735	COG0151	Belongs to the GarS family
I6L27_02745	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6L27_02775	COG0735	belongs to the Fur family
I6L27_02800	COG2308	Evidence 4 Homologs of previously reported genes of
I6L27_02810	COG1305	Transglutaminase-like
I6L27_02820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L27_02825	COG0305	Participates in initiation and elongation during chromosome replication
I6L27_02850	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6L27_02860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6L27_02890	COG0726	polysaccharide deacetylase
I6L27_02890	COG1649	PFAM Uncharacterised BCR, COG1649
I6L27_02895	COG1215	transferase activity, transferring glycosyl groups
I6L27_02900	COG3658	cytochrome
I6L27_02910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L27_02925	COG0583	DNA-binding transcription factor activity
I6L27_02940	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L27_02945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L27_02950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L27_02965	COG1960	acyl-CoA dehydrogenase activity
I6L27_02970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L27_02985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6L27_02995	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6L27_03000	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6L27_03010	COG2205	protein histidine kinase activity
I6L27_03015	COG0745	RESPONSE REGULATOR receiver
I6L27_03020	COG0174	glutamine synthetase
I6L27_03035	COG0477	Major facilitator Superfamily
I6L27_03040	COG0729	surface antigen
I6L27_03070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L27_03075	COG2814	Major facilitator Superfamily
I6L27_03085	COG0583	DNA-binding transcription factor activity
I6L27_03100	COG1187	pseudouridine synthase activity
I6L27_03120	COG0802	atpase or kinase
I6L27_03125	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L27_03135	COG1923	regulation of RNA biosynthetic process
I6L27_03140	COG0697	spore germination
I6L27_03150	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L27_03160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L27_03165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L27_03165	COG0519	Catalyzes the synthesis of GMP from XMP
I6L27_03170	COG4302	ethanolamine ammonia-lyase activity
I6L27_03175	COG4303	Ethanolamine ammonia lyase large subunit
I6L27_03180	COG0531	amino acid
I6L27_03200	COG1454	alcohol dehydrogenase
I6L27_03205	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L27_03215	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6L27_03235	COG0308	aminopeptidase N
I6L27_03275	COG1605	Chorismate mutase
I6L27_03285	COG4772	TonB-dependent receptor
I6L27_03290	COG4774	siderophore transport
I6L27_03345	COG1733	regulation of RNA biosynthetic process
I6L27_03370	COG0583	DNA-binding transcription factor activity
I6L27_03415	COG0488	(ABC) transporter
I6L27_03420	COG0589	response to stress
I6L27_03440	COG3135	benzoate transporter
I6L27_03445	COG1522	sequence-specific DNA binding
I6L27_03455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L27_03460	COG0583	DNA-binding transcription factor activity
I6L27_03470	COG0183	Belongs to the thiolase family
I6L27_03480	COG2030	dehydratase
I6L27_03485	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L27_03510	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6L27_03520	COG0824	Thioesterase
I6L27_03525	COG1454	alcohol dehydrogenase
I6L27_03550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6L27_03580	COG0069	glutamate synthase activity
I6L27_03605	COG2814	Major facilitator Superfamily
I6L27_03615	COG0439	Biotin carboxylase
I6L27_03620	COG0511	ligase activity, forming carbon-carbon bonds
I6L27_03650	COG2814	Major facilitator Superfamily
I6L27_03655	COG4264	IucA IucC family
I6L27_03660	COG4264	IucA IucC family
I6L27_03670	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L27_03685	COG1116	anion transmembrane transporter activity
I6L27_03685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L27_03700	COG2146	nitrite reductase [NAD(P)H] activity
I6L27_03700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L27_03705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L27_03710	COG0243	molybdopterin cofactor binding
I6L27_03720	COG0243	molybdopterin cofactor binding
I6L27_03725	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6L27_03740	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L27_03740	COG0315	cyclic pyranopterin monophosphate synthase activity
I6L27_03745	COG0303	'Molybdopterin
I6L27_03755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L27_03760	COG0697	spore germination
I6L27_03785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L27_03850	COG2204	response regulator
I6L27_03855	COG3852	Histidine kinase
I6L27_03880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L27_03885	COG0575	Belongs to the CDS family
I6L27_03900	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L27_03920	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L27_03935	COG2137	regulation of response to DNA damage stimulus
I6L27_03945	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6L27_03950	COG1011	Hydrolase
I6L27_03965	COG1522	sequence-specific DNA binding
I6L27_03975	COG1113	amino acid transport
I6L27_03995	COG0659	secondary active sulfate transmembrane transporter activity
I6L27_04015	COG3300	MHYT domain
I6L27_04015	COG5001	Diguanylate cyclase
I6L27_04030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L27_04030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L27_04030	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6L27_04035	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L27_04040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L27_04040	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L27_04060	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6L27_04070	COG0024	Methionine aminopeptidase
I6L27_04075	COG0583	DNA-binding transcription factor activity
I6L27_04085	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6L27_04090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L27_04095	COG0517	IMP dehydrogenase activity
I6L27_04095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L27_04120	COG0552	protein localization to endoplasmic reticulum
I6L27_04130	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I6L27_04145	COG4890	Cyd operon protein YbgT
I6L27_04150	COG1294	oxidase, subunit
I6L27_04165	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L27_04175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L27_04190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L27_04195	COG0569	domain protein
I6L27_04200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L27_04230	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6L27_04235	COG0542	response to heat
I6L27_04245	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L27_04260	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L27_04260	COG1902	pentaerythritol trinitrate reductase activity
I6L27_04300	COG0148	phosphopyruvate hydratase activity
I6L27_04305	COG2323	membrane
I6L27_04315	COG4773	Receptor
I6L27_04320	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6L27_04330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L27_04335	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L27_04340	COG0183	Belongs to the thiolase family
I6L27_04345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6L27_04350	COG0596	Alpha beta hydrolase
I6L27_04355	COG2271	Major facilitator Superfamily
I6L27_04360	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L27_04365	COG3485	protocatechuate 3,4-dioxygenase
I6L27_04370	COG3485	protocatechuate 3,4-dioxygenase
I6L27_04375	COG0710	3-dehydroquinate dehydratase activity
I6L27_04380	COG3420	alginic acid biosynthetic process
I6L27_04385	COG3659	wide pore channel activity
I6L27_04390	COG4993	Dehydrogenase
I6L27_04400	COG2391	methyltransferase activity
I6L27_04415	COG1414	Transcriptional regulator
I6L27_04420	COG0583	DNA-binding transcription factor activity
I6L27_04425	COG1960	acyl-CoA dehydrogenase activity
I6L27_04450	COG2814	Major facilitator Superfamily
I6L27_04460	COG0154	amidase activity
I6L27_04480	COG4638	Rieske (2fe-2S)
I6L27_04490	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_04500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L27_04510	COG3733	amine oxidase
I6L27_04525	COG1012	belongs to the aldehyde dehydrogenase family
I6L27_04530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L27_04535	COG0183	Belongs to the thiolase family
I6L27_04540	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L27_04545	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L27_04555	COG4829	muconolactone delta-isomerase
I6L27_04560	COG4948	Mandelate Racemase Muconate Lactonizing
I6L27_04565	COG0583	DNA-binding transcription factor activity
I6L27_04575	COG2186	Transcriptional regulator
I6L27_04595	COG1012	belongs to the aldehyde dehydrogenase family
I6L27_04600	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_04605	COG1414	Transcriptional regulator
I6L27_04610	COG1053	succinate dehydrogenase
I6L27_04625	COG3659	wide pore channel activity
I6L27_04630	COG1309	transcriptional regulator
I6L27_04650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6L27_04660	COG1053	succinate dehydrogenase
I6L27_04665	COG1053	succinate dehydrogenase
I6L27_04685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L27_04695	COG0583	DNA-binding transcription factor activity
I6L27_04715	COG1012	belongs to the aldehyde dehydrogenase family
I6L27_04720	COG1454	alcohol dehydrogenase
I6L27_04725	COG3485	protocatechuate 3,4-dioxygenase
I6L27_04740	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L27_04745	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L27_04750	COG0183	Belongs to the thiolase family
I6L27_04770	COG1234	tRNA 3'-trailer cleavage
I6L27_04775	COG2271	Major facilitator Superfamily
I6L27_04785	COG3971	2-oxopent-4-enoate hydratase activity
I6L27_04790	COG4569	acetaldehyde dehydrogenase (acetylating) activity
I6L27_04810	COG0583	DNA-binding transcription factor activity
I6L27_04815	COG4638	Rieske (2fe-2S)
I6L27_04820	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6L27_04830	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_04835	COG3384	dioxygenase
I6L27_04840	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L27_04845	COG2814	Major facilitator Superfamily
I6L27_04850	COG2814	Major facilitator Superfamily
I6L27_04855	COG0583	DNA-binding transcription factor activity
I6L27_04875	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L27_04875	COG1902	pentaerythritol trinitrate reductase activity
I6L27_04915	COG1309	transcriptional regulator
I6L27_04920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L27_04920	COG3321	synthase
I6L27_04920	COG4221	oxidoreductase activity
I6L27_04920	COG0604	alcohol dehydrogenase
I6L27_04925	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_04935	COG1733	regulation of RNA biosynthetic process
I6L27_04940	COG0702	epimerase
I6L27_04955	COG4689	acetoacetate decarboxylase
I6L27_04965	COG1902	pentaerythritol trinitrate reductase activity
I6L27_04970	COG1473	amidohydrolase
I6L27_05100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L27_05115	COG2271	Major facilitator Superfamily
I6L27_05125	COG1566	PFAM secretion protein HlyD family protein
I6L27_05140	COG1012	belongs to the aldehyde dehydrogenase family
I6L27_05145	COG0129	dihydroxy-acid dehydratase activity
I6L27_05155	COG0583	DNA-binding transcription factor activity
I6L27_05160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L27_05170	COG2084	Dehydrogenase
I6L27_05185	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6L27_05190	COG0583	DNA-binding transcription factor activity
I6L27_05195	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_05200	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_05205	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_05215	COG1960	acyl-CoA dehydrogenase activity
I6L27_05225	COG0318	PFAM AMP-dependent synthetase and ligase
I6L27_05235	COG2207	Transcriptional regulator
I6L27_05250	COG1064	alcohol dehydrogenase
I6L27_05255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L27_05275	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L27_05280	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_05285	COG3118	belongs to the thioredoxin family
I6L27_05290	COG1902	pentaerythritol trinitrate reductase activity
I6L27_05300	COG1309	transcriptional regulator
I6L27_05325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L27_05330	COG1120	ATPase activity
I6L27_05350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L27_05415	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6L27_05465	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_05475	COG2207	Transcriptional regulator
I6L27_05495	COG1073	alpha beta
I6L27_05505	COG0477	Major facilitator Superfamily
I6L27_05510	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_05515	COG0371	Dehydrogenase
I6L27_05525	COG0583	DNA-binding transcription factor activity
I6L27_05545	COG2814	Major facilitator Superfamily
I6L27_05550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L27_05570	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6L27_05580	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L27_05590	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_05595	COG0583	DNA-binding transcription factor activity
I6L27_05600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L27_05670	COG3539	Fimbrial protein
I6L27_05695	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6L27_05705	COG0753	catalase activity
I6L27_05725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L27_05785	COG3433	isochorismatase activity
I6L27_05785	COG1535	isochorismatase
I6L27_05790	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_05805	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6L27_05810	COG4149	molybdate abc transporter
I6L27_05815	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6L27_05825	COG4638	Rieske (2fe-2S)
I6L27_05830	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6L27_05835	COG0543	2 iron, 2 sulfur cluster binding
I6L27_05835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L27_05850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L27_05860	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_05880	COG2207	Transcriptional regulator
I6L27_05885	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_05890	COG2610	gluconate transmembrane transporter activity
I6L27_05910	COG0583	DNA-binding transcription factor activity
I6L27_05920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L27_05925	COG2031	fatty acid transporter
I6L27_05930	COG0183	Belongs to the thiolase family
I6L27_05935	COG0583	DNA-binding transcription factor activity
I6L27_05940	COG0583	DNA-binding transcription factor activity
I6L27_05955	COG1027	Aspartate ammonia-lyase
I6L27_05965	COG0477	Major facilitator Superfamily
I6L27_05975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L27_05980	COG1733	regulation of RNA biosynthetic process
I6L27_05985	COG2207	Transcriptional regulator
I6L27_05985	COG3708	Transcriptional regulator
I6L27_06000	COG0730	response to heat
I6L27_06020	COG3781	membrane
I6L27_06025	COG1063	alcohol dehydrogenase
I6L27_06035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L27_06040	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L27_06045	COG0022	dehydrogenase e1 component
I6L27_06050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6L27_06055	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L27_06070	COG3706	GGDEF domain
I6L27_06090	COG0133	tryptophan synthase activity
I6L27_06100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L27_06130	COG0583	DNA-binding transcription factor activity
I6L27_06135	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L27_06145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6L27_06200	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L27_06205	COG4773	Receptor
I6L27_06230	COG0730	response to heat
I6L27_06235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L27_06255	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6L27_06270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L27_06275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6L27_06290	COG1960	acyl-CoA dehydrogenase activity
I6L27_06295	COG1960	acyl-CoA dehydrogenase activity
I6L27_06300	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L27_06305	COG2207	Transcriptional regulator
I6L27_06310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L27_06315	COG0776	regulation of translation
I6L27_06340	COG0822	iron-sulfur transferase activity
I6L27_06345	COG0316	Belongs to the HesB IscA family
I6L27_06375	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L27_06395	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L27_06400	COG0702	epimerase
I6L27_06440	COG0601	transmembrane transport
I6L27_06445	COG0339	signal peptide processing
I6L27_06450	COG4166	transmembrane transport
I6L27_06495	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L27_06500	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6L27_06515	COG2431	L-lysine efflux transmembrane transporter activity
I6L27_06530	COG0776	regulation of translation
I6L27_06595	COG0084	hydrolase, TatD family'
I6L27_06615	COG1663	tetraacyldisaccharide 4'-kinase activity
I6L27_06620	COG1132	(ABC) transporter
I6L27_06630	COG0811	peptide transport
I6L27_06635	COG1475	DNA binding
I6L27_06640	COG1192	Involved in chromosome partitioning
I6L27_06650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6L27_06655	COG3178	'Phosphotransferase
I6L27_06665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L27_06690	COG0424	maF-like protein
I6L27_06695	COG2850	peptidyl-arginine hydroxylation
I6L27_06705	COG0640	Transcriptional regulator
I6L27_06715	COG3619	membrane
I6L27_06720	COG3122	Protein conserved in bacteria
I6L27_06725	COG1132	(ABC) transporter
I6L27_06745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6L27_06750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L27_06760	COG0506	proline dehydrogenase activity
I6L27_06760	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L27_06760	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L27_06765	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6L27_06780	COG3698	Phosphodiester glycosidase
I6L27_06790	COG2353	YceI-like domain
I6L27_06800	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L27_06845	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6L27_06845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L27_06870	COG3539	Fimbrial protein
I6L27_06895	COG0583	DNA-binding transcription factor activity
I6L27_06900	COG0697	spore germination
I6L27_06910	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6L27_06920	COG0583	DNA-binding transcription factor activity
I6L27_06955	COG2161	toxin-antitoxin pair type II binding
I6L27_06970	COG4974	Belongs to the 'phage' integrase family
I6L27_06980	COG1309	transcriptional regulator
I6L27_06995	COG1522	sequence-specific DNA binding
I6L27_07005	COG1126	abc transporter atp-binding protein
I6L27_07010	COG0765	amino acid transport
I6L27_07015	COG0765	amino acid transport
I6L27_07045	COG1464	Belongs to the NlpA lipoprotein family
I6L27_07055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L27_07060	COG2011	ABC-type metal ion transport system permease component
I6L27_07065	COG0012	GTP binding
I6L27_07085	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6L27_07120	COG2207	Transcriptional regulator
I6L27_07120	COG1917	Cupin 2, conserved barrel domain protein
I6L27_07125	COG0386	Belongs to the glutathione peroxidase family
I6L27_07135	COG0436	Aminotransferase
I6L27_07140	COG1301	dicarboxylic acid transport
I6L27_07175	COG3634	alkyl hydroperoxide reductase activity
I6L27_07190	COG0583	DNA-binding transcription factor activity
I6L27_07195	COG0431	NADPH-dependent FMN reductase
I6L27_07200	COG0798	PFAM Bile acid sodium symporter
I6L27_07210	COG0640	Transcriptional regulator
I6L27_07225	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6L27_07235	COG0583	DNA-binding transcription factor activity
I6L27_07245	COG1953	Uracil, thiamine, allantoin
I6L27_07255	COG2175	clavaminate synthase activity
I6L27_07260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L27_07265	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6L27_07270	COG4521	taurine ABC transporter
I6L27_07280	COG0477	Major facilitator Superfamily
I6L27_07300	COG1271	oxidase subunit
I6L27_07305	COG1294	oxidase, subunit
I6L27_07315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L27_07335	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6L27_07355	COG3052	prosthetic group binding
I6L27_07360	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6L27_07370	COG0583	DNA-binding transcription factor activity
I6L27_07385	COG2814	Major facilitator Superfamily
I6L27_07405	COG1346	cytolysis
I6L27_07415	COG0583	DNA-binding transcription factor activity
I6L27_07420	COG0625	glutathione transferase activity
I6L27_07425	COG0625	glutathione transferase activity
I6L27_07430	COG0583	DNA-binding transcription factor activity
I6L27_07435	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_07445	COG1045	serine acetyltransferase
I6L27_07450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L27_07455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6L27_07460	COG1280	lysine exporter protein (LysE YggA)
I6L27_07470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L27_07475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L27_07485	COG0765	amino acid transport
I6L27_07490	COG0765	amino acid transport
I6L27_07510	COG0784	Response regulator, receiver
I6L27_07510	COG2205	protein histidine kinase activity
I6L27_07530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L27_07550	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_07595	COG0583	DNA-binding transcription factor activity
I6L27_07605	COG2814	Major facilitator Superfamily
I6L27_07615	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6L27_07620	COG0318	PFAM AMP-dependent synthetase and ligase
I6L27_07625	COG1309	transcriptional regulator
I6L27_07630	COG1960	acyl-CoA dehydrogenase activity
I6L27_07635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L27_07640	COG1024	Enoyl-CoA hydratase
I6L27_07645	COG4770	biotin carboxylase activity
I6L27_07655	COG0583	DNA-binding transcription factor activity
I6L27_07670	COG1960	acyl-CoA dehydrogenase activity
I6L27_07680	COG2814	Major facilitator Superfamily
I6L27_07690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L27_07695	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L27_07700	COG2814	Major facilitator Superfamily
I6L27_07705	COG1960	acyl-CoA dehydrogenase activity
I6L27_07710	COG1024	Enoyl-CoA hydratase
I6L27_07715	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_07720	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L27_07725	COG0183	Belongs to the thiolase family
I6L27_07735	COG2814	Major facilitator Superfamily
I6L27_07745	COG1024	Enoyl-CoA hydratase
I6L27_07760	COG1960	acyl-CoA dehydrogenase activity
I6L27_07765	COG2814	Major facilitator Superfamily
I6L27_07770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L27_07775	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6L27_07790	COG3842	ATPase activity
I6L27_07795	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L27_07810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L27_07815	COG1414	Transcriptional regulator
I6L27_07840	COG1278	Cold shock
I6L27_07870	COG1309	transcriptional regulator
I6L27_07890	COG2050	protein possibly involved in aromatic compounds catabolism
I6L27_07900	COG3327	negative regulation of DNA-templated transcription, initiation
I6L27_07905	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6L27_07910	COG0183	Belongs to the thiolase family
I6L27_07915	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L27_07920	COG1024	Enoyl-CoA hydratase
I6L27_07925	COG1024	Enoyl-CoA hydratase
I6L27_07930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L27_07935	COG2151	metal-sulfur cluster biosynthetic enzyme
I6L27_07940	COG3396	Phenylacetate-CoA oxygenase
I6L27_07945	COG3460	Phenylacetate-CoA oxygenase
I6L27_07950	COG3396	Phenylacetate-CoA oxygenase
I6L27_07955	COG1012	belongs to the aldehyde dehydrogenase family
I6L27_07955	COG2030	dehydratase
I6L27_07960	COG1760	l-serine dehydratase
I6L27_07965	COG0531	amino acid
I6L27_07970	COG1012	belongs to the aldehyde dehydrogenase family
I6L27_07995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L27_08015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L27_08025	COG0789	Transcriptional regulator
I6L27_08035	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6L27_08040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L27_08055	COG2807	transmembrane transport
I6L27_08060	COG0590	tRNA wobble adenosine to inosine editing
I6L27_08110	COG2885	chlorophyll binding
I6L27_08230	COG0477	Major facilitator Superfamily
I6L27_08245	COG1116	anion transmembrane transporter activity
I6L27_08250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L27_08260	COG0864	Transcriptional regulator
I6L27_08270	COG1733	regulation of RNA biosynthetic process
I6L27_08275	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L27_08295	COG1063	alcohol dehydrogenase
I6L27_08300	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L27_08325	COG0038	chloride channel
I6L27_08330	COG4770	biotin carboxylase activity
I6L27_08350	COG1914	H( )-stimulated, divalent metal cation uptake system
I6L27_08365	COG1595	DNA-templated transcription, initiation
I6L27_08375	COG3220	belongs to the UPF0276 family
I6L27_08425	COG0598	Magnesium transport protein CorA
I6L27_08460	COG1234	tRNA 3'-trailer cleavage
I6L27_08465	COG1309	transcriptional regulator
I6L27_08520	COG2274	protein secretion by the type I secretion system
I6L27_08610	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6L27_08620	COG4122	O-methyltransferase activity
I6L27_08630	COG0110	maltose O-acetyltransferase activity
I6L27_08650	COG1538	Outer membrane efflux protein
I6L27_08655	COG1137	ATPase activity
I6L27_08660	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6L27_08670	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6L27_08705	COG3561	AntA/AntB antirepressor
I6L27_08720	COG2814	Major facilitator Superfamily
I6L27_08750	COG0668	transmembrane transport
I6L27_08795	COG1309	transcriptional regulator
I6L27_08825	COG2226	methyltransferase
I6L27_08850	COG1278	Cold shock
I6L27_08855	COG1560	Kdo2-lipid A biosynthetic process
I6L27_08860	COG1280	lysine exporter protein (LysE YggA)
I6L27_08895	COG1570	exodeoxyribonuclease VII activity
I6L27_08975	COG2871	sodium ion transport
I6L27_08985	COG0583	DNA-binding transcription factor activity
I6L27_08995	COG4638	Rieske (2fe-2S)
I6L27_09000	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6L27_09005	COG0543	2 iron, 2 sulfur cluster binding
I6L27_09005	COG0633	Ferredoxin
I6L27_09010	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_09015	COG3135	benzoate transporter
I6L27_09020	COG2814	Major facilitator Superfamily
I6L27_09035	COG1643	Atp-dependent helicase
I6L27_09060	COG3634	alkyl hydroperoxide reductase activity
I6L27_09080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6L27_09090	COG0625	glutathione transferase activity
I6L27_09100	COG2885	chlorophyll binding
I6L27_09130	COG1058	Belongs to the CinA family
I6L27_09130	COG1546	Belongs to the CinA family
I6L27_09135	COG0542	response to heat
I6L27_09150	COG1765	OsmC-like protein
I6L27_09165	COG0667	Aldo Keto reductase
I6L27_09180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6L27_09195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L27_09205	COG0527	aspartate kinase activity
I6L27_09215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6L27_09225	COG3038	cytochrome b561
I6L27_09230	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L27_09235	COG2252	PERMEase
I6L27_09245	COG1741	Belongs to the pirin family
I6L27_09250	COG1309	transcriptional regulator
I6L27_09260	COG0300	oxidoreductase activity
I6L27_09265	COG2072	flavoprotein involved in K transport
I6L27_09270	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6L27_09300	COG1944	ATP diphosphatase activity
I6L27_09320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L27_09335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L27_09350	COG2814	Major facilitator Superfamily
I6L27_09355	COG1024	Enoyl-CoA hydratase
I6L27_09360	COG1012	belongs to the aldehyde dehydrogenase family
I6L27_09370	COG1960	acyl-CoA dehydrogenase activity
I6L27_09395	COG2186	Transcriptional regulator
I6L27_09400	COG1012	belongs to the aldehyde dehydrogenase family
I6L27_09410	COG4948	Mandelate Racemase Muconate Lactonizing
I6L27_09415	COG2271	Major facilitator Superfamily
I6L27_09420	COG2721	sulfolactate sulfo-lyase activity
I6L27_09425	COG0697	spore germination
I6L27_09460	COG1113	amino acid transport
I6L27_09480	COG1012	belongs to the aldehyde dehydrogenase family
I6L27_09500	COG0531	amino acid
I6L27_09510	COG1113	amino acid transport
I6L27_09525	COG4269	membrane
I6L27_09550	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L27_09550	COG1902	pentaerythritol trinitrate reductase activity
I6L27_09560	COG2203	Gaf domain
I6L27_09560	COG3706	GGDEF domain
I6L27_09560	COG4251	negative regulation of phosphorylation
I6L27_09560	COG5001	Diguanylate cyclase
I6L27_09570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L27_09590	COG4172	Belongs to the ABC transporter superfamily
I6L27_09595	COG4239	(ABC) transporter, permease
I6L27_09600	COG4174	ABC transporter (Permease)
I6L27_09605	COG4166	transmembrane transport
I6L27_09610	COG0741	lytic transglycosylase activity
I6L27_09610	COG1388	LysM domain
I6L27_09650	COG0583	DNA-binding transcription factor activity
I6L27_09655	COG1279	arginine transmembrane transporter activity
I6L27_09665	COG0789	Transcriptional regulator
I6L27_09675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L27_09680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L27_09685	COG0006	proline dipeptidase activity
I6L27_09725	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L27_09740	COG3384	dioxygenase
I6L27_09750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L27_09755	COG2878	Part of a membrane complex involved in electron transport
I6L27_09760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L27_09785	COG0768	penicillin binding
I6L27_09790	COG0742	ribosomal rna small subunit methyltransferase
I6L27_09805	COG0830	nickel cation binding
I6L27_09815	COG0804	urea catabolic process
I6L27_09840	COG3015	lipoprotein NlpE involved in copper resistance
I6L27_09855	COG1253	flavin adenine dinucleotide binding
I6L27_09860	COG2851	Citrate transporter
I6L27_09905	COG1773	rubredoxin
I6L27_09910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L27_09915	COG2267	carboxylic ester hydrolase activity
I6L27_09920	COG0583	DNA-binding transcription factor activity
I6L27_09950	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6L27_09955	COG4181	ATPase activity
I6L27_09980	COG4771	TonB-dependent receptor
I6L27_10000	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L27_10020	COG0306	phosphate transporter
I6L27_10035	COG3958	Transketolase
I6L27_10040	COG3959	Transketolase, thiamine diphosphate binding domain
I6L27_10045	COG2271	Major facilitator Superfamily
I6L27_10050	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_10055	COG0583	DNA-binding transcription factor activity
I6L27_10070	COG2223	nitrite transmembrane transporter activity
I6L27_10075	COG2207	Transcriptional regulator
I6L27_10080	COG2066	Belongs to the glutaminase family
I6L27_10085	COG0242	peptide deformylase activity
I6L27_10090	COG0477	Major facilitator Superfamily
I6L27_10100	COG0028	Belongs to the TPP enzyme family
I6L27_10115	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_10120	COG2267	carboxylic ester hydrolase activity
I6L27_10130	COG2271	Major facilitator Superfamily
I6L27_10165	COG1414	Transcriptional regulator
I6L27_10180	COG1024	Enoyl-CoA hydratase
I6L27_10190	COG1215	transferase activity, transferring glycosyl groups
I6L27_10195	COG0726	polysaccharide deacetylase
I6L27_10195	COG1649	PFAM Uncharacterised BCR, COG1649
I6L27_10205	COG4681	YaeQ
I6L27_10215	COG0523	cobalamin synthesis protein
I6L27_10225	COG1607	acyl-coa hydrolase
I6L27_10235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L27_10240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L27_10245	COG1309	transcriptional regulator
I6L27_10270	COG2040	homocysteine
I6L27_10275	COG0531	amino acid
I6L27_10330	COG1595	DNA-templated transcription, initiation
I6L27_10340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L27_10345	COG0477	Major facilitator Superfamily
I6L27_10380	COG1401	restriction endodeoxyribonuclease activity
I6L27_10395	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6L27_10405	COG0405	Gamma-glutamyltransferase
I6L27_10410	COG2814	Major facilitator Superfamily
I6L27_10420	COG2050	protein possibly involved in aromatic compounds catabolism
I6L27_10435	COG1090	epimerase
I6L27_10455	COG0420	3'-5' exonuclease activity
I6L27_10480	COG0735	belongs to the Fur family
I6L27_10485	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L27_10490	COG2914	Belongs to the UPF0125 (RnfH) family
I6L27_10505	COG0121	glutamine amidotransferase
I6L27_10520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L27_10530	COG0210	DNA helicase
I6L27_10535	COG2885	chlorophyll binding
I6L27_10540	COG0204	Acyl-transferase
I6L27_10555	COG2894	cell division
I6L27_10570	COG1280	lysine exporter protein (LysE YggA)
I6L27_10575	COG1674	ftsk spoiiie
I6L27_10580	COG0492	ferredoxin-NADP+ reductase activity
I6L27_10585	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6L27_10595	COG0456	acetyltransferase
I6L27_10610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L27_10615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6L27_10625	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6L27_10640	COG1981	membrane
I6L27_10650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L27_10650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6L27_10670	COG1012	belongs to the aldehyde dehydrogenase family
I6L27_10675	COG4638	Rieske (2fe-2S)
I6L27_10680	COG0657	acetylesterase activity
I6L27_10690	COG0473	3-isopropylmalate dehydrogenase activity
I6L27_10695	COG0583	DNA-binding transcription factor activity
I6L27_10715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L27_10750	COG0358	DNA primase activity
I6L27_10765	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6L27_10790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L27_10820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L27_10830	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6L27_10830	COG0352	thiamine-phosphate diphosphorylase activity
I6L27_10830	COG0351	phosphomethylpyrimidine kinase
I6L27_10835	COG1652	LysM domain
I6L27_10860	COG1399	metal-binding, possibly nucleic acid-binding protein
I6L27_10865	COG3101	peptidyl-lysine hydroxylation
I6L27_10870	COG0009	L-threonylcarbamoyladenylate synthase
I6L27_10875	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6L27_10880	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6L27_10895	COG4106	trans-aconitate 2-methyltransferase activity
I6L27_10910	COG2226	methyltransferase
I6L27_10910	COG0596	Alpha beta hydrolase
I6L27_10910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L27_10920	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6L27_10925	COG2223	nitrite transmembrane transporter activity
I6L27_10945	COG1196	nuclear chromosome segregation
I6L27_10955	COG0730	response to heat
I6L27_10970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L27_11030	COG0489	protein tyrosine kinase activity
I6L27_11040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L27_11040	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L27_11075	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6L27_11080	COG2081	HI0933 family
I6L27_11090	COG0668	transmembrane transport
I6L27_11110	COG0583	DNA-binding transcription factor activity
I6L27_11115	COG1278	Cold shock
I6L27_11130	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L27_11135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L27_11165	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6L27_11190	COG2199	diguanylate cyclase activity
I6L27_11205	COG0745	RESPONSE REGULATOR receiver
I6L27_11220	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L27_11230	COG0384	phenazine biosynthesis protein PhzF
I6L27_11275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L27_11290	COG0583	DNA-binding transcription factor activity
I6L27_11345	COG0583	DNA-binding transcription factor activity
I6L27_11360	COG0583	DNA-binding transcription factor activity
I6L27_11365	COG1053	succinate dehydrogenase
I6L27_11380	COG1309	transcriptional regulator
I6L27_11385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6L27_11390	COG2814	Major facilitator Superfamily
I6L27_11395	COG1960	acyl-CoA dehydrogenase activity
I6L27_11400	COG0583	DNA-binding transcription factor activity
I6L27_11405	COG1063	alcohol dehydrogenase
I6L27_11435	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6L27_11440	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6L27_11445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L27_11465	COG2132	Multicopper oxidase
I6L27_11475	COG0561	phosphatase activity
I6L27_11480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L27_11490	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6L27_11505	COG1214	PFAM Peptidase M22, glycoprotease
I6L27_11565	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6L27_11570	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6L27_11575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6L27_11620	COG2853	Lipoprotein
I6L27_11635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L27_11645	COG1846	Transcriptional regulator
I6L27_11650	COG1764	response to oxidative stress
I6L27_11690	COG0037	tRNA processing
I6L27_11700	COG0248	Ppx GppA phosphatase
I6L27_11730	COG0072	phenylalanine-tRNA ligase activity
I6L27_11760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6L27_11775	COG1238	metal cluster binding
I6L27_11780	COG0625	glutathione transferase activity
I6L27_11795	COG0318	PFAM AMP-dependent synthetase and ligase
I6L27_11800	COG3028	Belongs to the UPF0307 family
I6L27_11805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L27_11825	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6L27_11830	COG0617	tRNA 3'-terminal CCA addition
I6L27_11835	COG1555	photosystem II stabilization
I6L27_11840	COG3956	TIGRFAM MazG family protein
I6L27_11850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L27_11870	COG2205	protein histidine kinase activity
I6L27_11870	COG0784	Response regulator, receiver
I6L27_11870	COG5002	protein histidine kinase activity
I6L27_11875	COG1024	Enoyl-CoA hydratase
I6L27_11880	COG2084	Dehydrogenase
I6L27_11885	COG3622	Belongs to the hyi family
I6L27_11915	COG0697	spore germination
I6L27_11925	COG2814	Major facilitator Superfamily
I6L27_11950	COG2072	flavoprotein involved in K transport
I6L27_11955	COG0492	ferredoxin-NADP+ reductase activity
I6L27_11960	COG0431	NADPH-dependent FMN reductase
I6L27_11965	COG0798	PFAM Bile acid sodium symporter
I6L27_11975	COG0640	Transcriptional regulator
I6L27_12010	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L27_12035	COG2132	Multicopper oxidase
I6L27_12050	COG2205	protein histidine kinase activity
I6L27_12135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L27_12145	COG0583	DNA-binding transcription factor activity
I6L27_12155	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6L27_12165	COG0084	hydrolase, TatD family'
I6L27_12180	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6L27_12200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6L27_12205	COG0440	acetolactate synthase activity
I6L27_12210	COG0028	Belongs to the TPP enzyme family
I6L27_12230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L27_12235	COG0577	efflux transmembrane transporter activity
I6L27_12235	COG1136	(ABC) transporter
I6L27_12255	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6L27_12260	COG1162	GTPase activity
I6L27_12270	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L27_12290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L27_12295	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_12350	COG0318	PFAM AMP-dependent synthetase and ligase
I6L27_12360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L27_12385	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L27_12405	COG1426	Protein conserved in bacteria
I6L27_12440	COG0793	Belongs to the peptidase S41A family
I6L27_12455	COG2267	carboxylic ester hydrolase activity
I6L27_12465	COG1012	belongs to the aldehyde dehydrogenase family
I6L27_12470	COG3265	gluconokinase activity
I6L27_12480	COG0800	Aldolase
I6L27_12495	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L27_12500	COG0280	phosphate acetyltransferase
I6L27_12500	COG0857	belongs to the CobB CobQ family
I6L27_12505	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L27_12505	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L27_12525	COG0740	serine-type endopeptidase activity
I6L27_12535	COG4774	siderophore transport
I6L27_12545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L27_12555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L27_12555	COG2813	Specifically methylates the guanine in position
I6L27_12655	COG0788	formyltetrahydrofolate deformylase activity
I6L27_12680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L27_12680	COG4651	solute:proton antiporter activity
I6L27_12700	COG0724	RNA recognition motif
I6L27_12705	COG0210	DNA helicase
I6L27_12730	COG1733	regulation of RNA biosynthetic process
I6L27_12740	COG2900	Belongs to the SlyX family
I6L27_12745	COG0488	(ABC) transporter
I6L27_12755	COG1560	Kdo2-lipid A biosynthetic process
I6L27_12765	COG1301	dicarboxylic acid transport
I6L27_12775	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L27_12820	COG0473	3-isopropylmalate dehydrogenase activity
I6L27_12845	COG0583	DNA-binding transcription factor activity
I6L27_12885	COG0583	DNA-binding transcription factor activity
I6L27_12895	COG0625	glutathione transferase activity
I6L27_12900	COG2378	regulation of single-species biofilm formation
I6L27_12905	COG0546	phosphoglycolate phosphatase activity
I6L27_12915	COG1530	ribonuclease E activity
I6L27_12920	COG0318	PFAM AMP-dependent synthetase and ligase
I6L27_12935	COG0583	DNA-binding transcription factor activity
I6L27_12940	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_12945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L27_12955	COG0534	Mate efflux family protein
I6L27_12970	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L27_12995	COG0493	'glutamate synthase
I6L27_13005	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6L27_13010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L27_13025	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6L27_13035	COG0644	oxidoreductase
I6L27_13035	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6L27_13050	COG4535	Mg2 and Co2 transporter CorC
I6L27_13060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L27_13060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L27_13080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L27_13090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6L27_13100	COG0484	heat shock protein binding
I6L27_13105	COG0789	Transcriptional regulator
I6L27_13110	COG0598	Magnesium transport protein CorA
I6L27_13115	COG1185	polyribonucleotide nucleotidyltransferase activity
I6L27_13125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L27_13130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L27_13135	COG1074	ATP-dependent DNA helicase activity
I6L27_13140	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6L27_13160	COG2226	methyltransferase
I6L27_13170	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L27_13175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L27_13180	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6L27_13195	COG2111	Na H antiporter
I6L27_13195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L27_13200	COG1006	Multisubunit Na H antiporter MnhC subunit
I6L27_13205	COG0651	ATP synthesis coupled electron transport
I6L27_13210	COG1863	multisubunit Na H antiporter MnhE subunit
I6L27_13215	COG2212	antiporter activity
I6L27_13220	COG1320	monovalent cation:proton antiporter activity
I6L27_13225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6L27_13235	COG0195	Participates in both transcription termination and antitermination
I6L27_13285	COG0237	dephospho-CoA kinase activity
I6L27_13295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L27_13310	COG0497	DNA recombination
I6L27_13320	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6L27_13355	COG2169	Transcriptional regulator
I6L27_13355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L27_13360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L27_13430	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6L27_13445	COG0326	Molecular chaperone. Has ATPase activity
I6L27_13460	COG2056	Na+-H+ antiporter family
I6L27_13530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L27_13560	COG0546	phosphoglycolate phosphatase activity
I6L27_13565	COG1716	ATPase activity
I6L27_13610	COG0181	hydroxymethylbilane synthase activity
I6L27_13620	COG3275	phosphorelay sensor kinase activity
I6L27_13640	COG1538	Outer membrane efflux protein
I6L27_13650	COG0697	spore germination
I6L27_13670	COG0494	nUDIX hydrolase
I6L27_13675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6L27_13680	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L27_13685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L27_13690	COG0772	Belongs to the SEDS family
I6L27_13715	COG4974	Belongs to the 'phage' integrase family
I6L27_13720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L27_13730	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L27_13740	COG2197	response regulator
I6L27_13755	COG0793	Belongs to the peptidase S41A family
I6L27_13760	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6L27_13765	COG0795	lipopolysaccharide-transporting ATPase activity
I6L27_13805	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L27_13805	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L27_13815	COG0004	ammonium transporteR
I6L27_13820	COG0347	Belongs to the P(II) protein family
I6L27_13830	COG0606	chelatase, subunit chli
I6L27_13835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L27_13840	COG0235	Class ii aldolase
I6L27_13845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L27_13865	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L27_13880	COG0318	PFAM AMP-dependent synthetase and ligase
I6L27_13890	COG0477	Major facilitator Superfamily
I6L27_13895	COG2860	membrane
I6L27_13905	COG1253	flavin adenine dinucleotide binding
I6L27_13920	COG2814	Major facilitator Superfamily
I6L27_13930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L27_13965	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6L27_13975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L27_14010	COG1309	transcriptional regulator
I6L27_14045	COG0758	DNA mediated transformation
I6L27_14055	COG0697	spore germination
I6L27_14060	COG1309	transcriptional regulator
I6L27_14075	COG0386	Belongs to the glutathione peroxidase family
I6L27_14095	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6L27_14105	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6L27_14145	COG1121	(ABC) transporter
I6L27_14150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L27_14155	COG1280	lysine exporter protein (LysE YggA)
I6L27_14160	COG2837	iron assimilation
I6L27_14165	COG0281	malic enzyme
I6L27_14210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L27_14210	COG0519	Catalyzes the synthesis of GMP from XMP
I6L27_14215	COG4399	Belongs to the UPF0754 family
I6L27_14220	COG2259	Doxx family
I6L27_14225	COG0586	Pfam SNARE associated Golgi protein
I6L27_14240	COG1192	Involved in chromosome partitioning
I6L27_14250	COG0271	Belongs to the BolA IbaG family
I6L27_14290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L27_14290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L27_14290	COG3321	synthase
I6L27_14290	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6L27_14295	COG1960	acyl-CoA dehydrogenase activity
I6L27_14300	COG0318	PFAM AMP-dependent synthetase and ligase
I6L27_14305	COG2197	response regulator
I6L27_14315	COG3916	Acyl-homoserine-lactone synthase
I6L27_14320	COG0477	Major facilitator Superfamily
I6L27_14325	COG1024	Enoyl-CoA hydratase
I6L27_14330	COG1024	Enoyl-CoA hydratase
I6L27_14335	COG1960	acyl-CoA dehydrogenase activity
I6L27_14340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L27_14360	COG1113	amino acid transport
I6L27_14365	COG1113	amino acid transport
I6L27_14370	COG0251	oxidation-reduction process
I6L27_14410	COG0564	pseudouridine synthase activity
I6L27_14460	COG1051	belongs to the nudix hydrolase family
I6L27_14490	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6L27_14505	COG1802	Transcriptional regulator
I6L27_14515	COG1448	Aminotransferase
I6L27_14520	COG0277	FAD linked oxidase domain protein
I6L27_14530	COG2186	Transcriptional regulator
I6L27_14540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L27_14545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L27_14560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L27_14575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L27_14585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6L27_14595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6L27_14600	COG0438	transferase activity, transferring glycosyl groups
I6L27_14605	COG0438	transferase activity, transferring glycosyl groups
I6L27_14615	COG0438	transferase activity, transferring glycosyl groups
I6L27_14635	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6L27_14665	COG0728	peptidoglycan biosynthetic process
I6L27_14670	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L27_14705	COG1017	nitric oxide dioxygenase activity
I6L27_14705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L27_14730	COG0546	phosphoglycolate phosphatase activity
I6L27_14735	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_14750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L27_14750	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6L27_14755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L27_14760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L27_14765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L27_14770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L27_14775	COG1116	anion transmembrane transporter activity
I6L27_14780	COG1309	transcriptional regulator
I6L27_14785	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6L27_14795	COG0196	riboflavin kinase activity
I6L27_14800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6L27_14810	COG1047	Peptidyl-prolyl cis-trans
I6L27_14850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L27_14855	COG0657	acetylesterase activity
I6L27_14905	COG2951	lytic endotransglycosylase activity
I6L27_14910	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6L27_14925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L27_14935	COG0671	phosphoesterase, PA-phosphatase related
I6L27_14940	COG0861	Integral membrane protein TerC family
I6L27_14950	COG0754	glutathionylspermidine amidase activity
I6L27_14960	COG0402	S-adenosylhomocysteine deaminase activity
I6L27_14975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L27_14980	COG1230	cation diffusion facilitator family transporter
I6L27_14995	COG0706	membrane insertase activity
I6L27_15020	COG0592	DNA-directed DNA polymerase activity
I6L27_15030	COG0187	DNA topoisomerase II activity
I6L27_15045	COG0488	(ABC) transporter
I6L27_15075	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6L27_15080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L27_15110	COG0625	glutathione transferase activity
I6L27_15120	COG0733	neurotransmitter:sodium symporter activity
I6L27_15160	COG2233	PERMEase
I6L27_15175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L27_15210	COG2814	Major facilitator Superfamily
I6L27_15215	COG0656	L-ascorbic acid biosynthetic process
I6L27_15220	COG0583	DNA-binding transcription factor activity
I6L27_15235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L27_15240	COG1064	alcohol dehydrogenase
I6L27_15245	COG2818	Glycosylase
I6L27_15260	COG1194	a g-specific adenine glycosylase
I6L27_15275	COG5487	UPF0391 membrane protein
I6L27_15280	COG2983	Belongs to the UPF0260 family
I6L27_15285	COG2133	pyrroloquinoline quinone binding
I6L27_15290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L27_15295	COG2116	formate transmembrane transporter activity
I6L27_15315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L27_15320	COG1335	isochorismatase
I6L27_15325	COG0385	Bile acid
I6L27_15330	COG0534	Mate efflux family protein
I6L27_15335	COG1683	Conserved Protein
I6L27_15350	COG0346	lactoylglutathione lyase activity
I6L27_15355	COG0625	glutathione transferase activity
I6L27_15365	COG1113	amino acid transport
I6L27_15375	COG0523	cobalamin synthesis protein
I6L27_15385	COG2188	Transcriptional regulator
I6L27_15415	COG0010	Belongs to the arginase family
I6L27_15425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6L27_15440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6L27_15450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6L27_15455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6L27_15555	COG0534	Mate efflux family protein
I6L27_15560	COG0436	Aminotransferase
I6L27_15565	COG2733	membrane
I6L27_15580	COG2918	glutathione biosynthetic process
I6L27_15615	COG3150	esterase
I6L27_15625	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6L27_15635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L27_15645	COG2233	PERMEase
I6L27_15650	COG2351	hydroxyisourate hydrolase activity
I6L27_15685	COG3706	GGDEF domain
I6L27_15700	COG1393	Belongs to the ArsC family
I6L27_15705	COG0708	Exodeoxyribonuclease III
I6L27_15745	COG0189	ligase activity
I6L27_15765	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6L27_15775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6L27_15790	COG4942	peptidase
I6L27_15800	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L27_15810	COG2119	membrane
I6L27_15815	COG4774	siderophore transport
I6L27_15820	COG0426	domain, Protein
I6L27_15820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L27_15840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6L27_15865	COG1902	pentaerythritol trinitrate reductase activity
I6L27_15870	COG1519	Transferase
I6L27_15875	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L27_15880	COG0668	transmembrane transport
I6L27_15890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L27_15895	COG1335	isochorismatase
I6L27_15900	COG1522	sequence-specific DNA binding
I6L27_15925	COG0784	Response regulator, receiver
I6L27_15925	COG2198	Histidine kinase
I6L27_15925	COG2205	protein histidine kinase activity
I6L27_15930	COG3162	membrane
I6L27_15935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L27_15945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L27_15955	COG3706	GGDEF domain
I6L27_15965	COG1309	transcriptional regulator
I6L27_15985	COG0300	oxidoreductase activity
I6L27_15995	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6L27_15995	COG0352	thiamine-phosphate diphosphorylase activity
I6L27_15995	COG0351	phosphomethylpyrimidine kinase
I6L27_16005	COG2814	Major facilitator Superfamily
I6L27_16055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6L27_16065	COG1113	amino acid transport
I6L27_16075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L27_16080	COG1012	belongs to the aldehyde dehydrogenase family
I6L27_16090	COG1335	isochorismatase
I6L27_16125	COG0583	DNA-binding transcription factor activity
I6L27_16145	COG2814	Major facilitator Superfamily
I6L27_16150	COG0583	DNA-binding transcription factor activity
I6L27_16170	COG0667	Aldo Keto reductase
I6L27_16205	COG1733	regulation of RNA biosynthetic process
I6L27_16210	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L27_16270	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L27_16285	COG2329	Antibiotic biosynthesis monooxygenase
I6L27_16290	COG0697	spore germination
I6L27_16315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L27_16345	COG0427	acetyl-CoA hydrolase
I6L27_16370	COG0659	secondary active sulfate transmembrane transporter activity
I6L27_16375	COG4221	oxidoreductase activity
I6L27_16380	COG2873	o-acetylhomoserine
I6L27_16385	COG0488	(ABC) transporter
I6L27_16460	COG0833	amino acid
I6L27_16505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L27_16510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L27_16525	COG2226	methyltransferase
I6L27_16575	COG0069	glutamate synthase activity
I6L27_16575	COG0067	glutamate synthase
I6L27_16575	COG0070	glutamate synthase
I6L27_16580	COG0493	'glutamate synthase
I6L27_16590	COG1704	LemA family
I6L27_16595	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L27_16610	COG3307	-O-antigen
I6L27_16630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L27_16645	COG0194	GDP metabolic process
I6L27_16695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6L27_16705	COG0335	large ribosomal subunit rRNA binding
I6L27_16715	COG5380	lipid catabolic process
I6L27_16720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6L27_16740	COG5006	permease, DMT superfamily
I6L27_16745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L27_16750	COG0277	FAD linked oxidase domain protein
I6L27_16760	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6L27_16765	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L27_16780	COG1289	transmembrane transporter activity
I6L27_16790	COG0628	permease
I6L27_16795	COG1192	Involved in chromosome partitioning
I6L27_16825	COG0833	amino acid
I6L27_16830	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L27_16835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L27_16845	COG1012	belongs to the aldehyde dehydrogenase family
I6L27_16870	COG1404	Belongs to the peptidase S8 family
I6L27_16885	COG0583	DNA-binding transcription factor activity
I6L27_16915	COG0752	glycyl-tRNA synthetase alpha subunit
I6L27_16940	COG0517	IMP dehydrogenase activity
I6L27_16940	COG0617	tRNA 3'-terminal CCA addition
I6L27_16940	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6L27_16945	COG1983	PspC domain protein
I6L27_16955	COG1960	acyl-CoA dehydrogenase activity
I6L27_16970	COG0408	coproporphyrinogen oxidase activity
I6L27_16990	COG0513	Belongs to the DEAD box helicase family
I6L27_17000	COG1127	ABC transporter
I6L27_17005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6L27_17015	COG2854	intermembrane phospholipid transfer
I6L27_17025	COG0598	Magnesium transport protein CorA
I6L27_17035	COG0494	nUDIX hydrolase
I6L27_17040	COG1040	competence protein
I6L27_17045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L27_17060	COG2937	Belongs to the GPAT DAPAT family
I6L27_17065	COG1946	Acyl-CoA thioesterase
I6L27_17070	COG1301	dicarboxylic acid transport
I6L27_17085	COG1959	2 iron, 2 sulfur cluster binding
I6L27_17090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L27_17090	COG1017	nitric oxide dioxygenase activity
I6L27_17100	COG0433	COG0433 Predicted ATPase
I6L27_17105	COG0626	cystathionine gamma-synthase activity
I6L27_17120	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6L27_17125	COG0088	Forms part of the polypeptide exit tunnel
I6L27_17260	COG1960	acyl-CoA dehydrogenase activity
I6L27_17265	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6L27_17295	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6L27_17300	COG0339	signal peptide processing
I6L27_17305	COG0557	exoribonuclease II activity
I6L27_17350	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6L27_17355	COG1295	ribonuclease BN
I6L27_17390	COG1702	phosphate starvation-inducible protein PhoH
I6L27_17400	COG0741	lytic transglycosylase activity
I6L27_17400	COG1196	nuclear chromosome segregation
I6L27_17400	COG0739	heme binding
I6L27_17430	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6L27_17435	COG1183	phosphatidylcholine synthase activity
I6L27_17480	COG1960	acyl-CoA dehydrogenase activity
I6L27_17485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L27_17490	COG1309	transcriptional regulator
I6L27_17505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L27_17510	COG1960	acyl-CoA dehydrogenase activity
I6L27_17530	COG2969	positive regulation of protein catabolic process
I6L27_17540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6L27_17545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6L27_17550	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6L27_17555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6L27_17560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L27_17580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L27_17590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L27_17595	COG1408	metallophosphoesterase
I6L27_17600	COG2885	chlorophyll binding
I6L27_17600	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6L27_17605	COG2199	diguanylate cyclase activity
I6L27_17650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L27_17675	COG1607	acyl-coa hydrolase
I6L27_17710	COG2350	Protein conserved in bacteria
I6L27_17725	COG3781	membrane
I6L27_17735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L27_17750	COG1862	Preprotein translocase
I6L27_17775	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6L27_17795	COG0726	polysaccharide deacetylase
I6L27_17800	COG0463	Glycosyl transferase, family 2
I6L27_17805	COG0438	transferase activity, transferring glycosyl groups
I6L27_17820	COG1215	transferase activity, transferring glycosyl groups
I6L27_17820	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6L27_17870	COG0625	glutathione transferase activity
I6L27_17875	COG0583	DNA-binding transcription factor activity
I6L27_17880	COG1960	acyl-CoA dehydrogenase activity
I6L27_17885	COG1960	acyl-CoA dehydrogenase activity
I6L27_17895	COG2205	protein histidine kinase activity
I6L27_17900	COG0745	RESPONSE REGULATOR receiver
I6L27_17910	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6L27_17930	COG2096	Adenosyltransferase
I6L27_17935	COG4206	TonB-dependent receptor
I6L27_17980	COG0285	dihydrofolate synthase activity
I6L27_18005	COG0450	alkyl hydroperoxide reductase
I6L27_18020	COG0477	Major facilitator Superfamily
I6L27_18025	COG1272	protein, Hemolysin III
I6L27_18035	COG2153	protein acetylation
I6L27_18055	COG0183	Belongs to the thiolase family
I6L27_18060	COG2207	Transcriptional regulator
I6L27_18080	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L27_18100	COG0183	Belongs to the thiolase family
I6L27_18110	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6L27_18110	COG2885	chlorophyll binding
I6L27_18120	COG1690	Belongs to the RtcB family
I6L27_18125	COG0833	amino acid
I6L27_18135	COG2233	PERMEase
I6L27_18140	COG1217	gtp-binding protein TYPA
I6L27_18165	COG2094	Belongs to the DNA glycosylase MPG family
I6L27_18170	COG4772	TonB-dependent receptor
I6L27_18175	COG1902	pentaerythritol trinitrate reductase activity
I6L27_18190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L27_18195	COG0354	folic acid binding
I6L27_18210	COG3189	MarR family transcriptional regulator
I6L27_18215	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L27_18220	COG3422	double-strand break repair
I6L27_18260	COG0840	transmembrane signaling receptor activity
I6L27_18275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L27_18290	COG5510	response to toxic substance
I6L27_18300	COG2832	Protein of unknown function (DUF454)
I6L27_18305	COG1376	ErfK ybiS ycfS ynhG family protein
I6L27_18345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L27_18355	COG1289	transmembrane transporter activity
I6L27_18360	COG2814	Major facilitator Superfamily
I6L27_18380	COG1115	amino acid carrier protein
I6L27_18385	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L27_18390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L27_18395	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6L27_18420	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6L27_18430	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6L27_18435	COG1077	Cell shape determining protein MreB Mrl
I6L27_18440	COG1792	Involved in formation and maintenance of cell shape
I6L27_18445	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6L27_18450	COG0424	maF-like protein
I6L27_18455	COG1530	ribonuclease E activity
I6L27_18465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L27_18485	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L27_18510	COG2207	Transcriptional regulator
I6L27_18570	COG1113	amino acid transport
I6L27_18580	COG0142	geranyltranstransferase activity
I6L27_18585	COG2315	Protein conserved in bacteria
I6L27_18600	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L27_18625	COG2194	sulfuric ester hydrolase activity
I6L27_18630	COG0745	RESPONSE REGULATOR receiver
I6L27_18635	COG0642	Histidine kinase
I6L27_18645	COG0004	ammonium transporteR
I6L27_18650	COG0583	DNA-binding transcription factor activity
I6L27_18670	COG0525	valine-tRNA ligase activity
I6L27_18680	COG1028	Short-chain dehydrogenase reductase Sdr
I6L27_18690	COG0393	Putative heavy-metal-binding
I6L27_18695	COG0393	Putative heavy-metal-binding
I6L27_18700	COG1538	Outer membrane efflux protein
I6L27_18710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L27_18715	COG0671	phosphoesterase, PA-phosphatase related
I6L27_18740	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6L27_18755	COG1648	precorrin-2 dehydrogenase activity
I6L27_18755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L27_18760	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6L27_18795	COG0531	amino acid
I6L27_18810	COG0321	lipoyl(octanoyl) transferase activity
I6L27_18815	COG2921	Belongs to the UPF0250 family
I6L27_18855	COG2009	succinate dehydrogenase
I6L27_18860	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6L27_18865	COG1053	succinate dehydrogenase
I6L27_18870	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L27_18895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L27_18915	COG2354	Protein conserved in bacteria
I6L27_18920	COG2321	neutral zinc metallopeptidase
I6L27_18940	COG2843	Capsule synthesis protein
I6L27_18955	COG0589	response to stress
I6L27_18975	COG0505	Belongs to the CarA family
I6L27_19005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L27_19010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6L27_19060	COG0477	Major facilitator Superfamily
I6L27_19065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6L27_19080	COG1597	lipid kinase activity
I6L27_19085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6L27_19165	COG3620	sequence-specific DNA binding
I6L27_19250	COG0604	alcohol dehydrogenase
I6L27_19250	COG3321	synthase
I6L27_19255	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6L27_19260	COG0583	DNA-binding transcription factor activity
I6L27_19265	COG4221	oxidoreductase activity
I6L27_19315	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L27_19320	COG3657	addiction module killer protein
I6L27_19335	COG0300	oxidoreductase activity
I6L27_19370	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6L27_19405	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
I6L27_19500	COG1785	Belongs to the alkaline phosphatase family
I6L27_19505	COG1475	DNA binding
I6L27_19510	COG1192	Involved in chromosome partitioning
I6L27_19525	COG3293	Transposase
I6L27_19530	COG1063	alcohol dehydrogenase
I6L27_19555	COG0604	alcohol dehydrogenase
I6L27_19560	COG1309	transcriptional regulator
I6L27_19585	COG0582	viral genome integration into host DNA
I6L27_19600	COG2130	NADP-dependent
I6L27_19605	COG1309	transcriptional regulator
I6L27_19615	COG1902	pentaerythritol trinitrate reductase activity
I6L27_19625	COG1979	alcohol dehydrogenase
I6L27_19640	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6L27_19750	COG3736	Type IV secretory pathway, component VirB8
I6L27_19765	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
I6L27_19830	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6L27_19870	COG2431	L-lysine efflux transmembrane transporter activity