locus-tag	class	description
I6L29_00040	COG1702	phosphate starvation-inducible protein PhoH
I6L29_00050	COG0739	heme binding
I6L29_00050	COG0741	lytic transglycosylase activity
I6L29_00050	COG1196	nuclear chromosome segregation
I6L29_00080	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6L29_00085	COG1183	phosphatidylcholine synthase activity
I6L29_00130	COG1960	acyl-CoA dehydrogenase activity
I6L29_00135	COG1309	transcriptional regulator
I6L29_00150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L29_00155	COG1960	acyl-CoA dehydrogenase activity
I6L29_00195	COG2969	positive regulation of protein catabolic process
I6L29_00205	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6L29_00210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6L29_00215	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6L29_00220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6L29_00225	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L29_00245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L29_00255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L29_00260	COG1408	metallophosphoesterase
I6L29_00265	COG2885	chlorophyll binding
I6L29_00265	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6L29_00270	COG2199	diguanylate cyclase activity
I6L29_00340	COG1607	acyl-coa hydrolase
I6L29_00375	COG2350	Protein conserved in bacteria
I6L29_00390	COG3781	membrane
I6L29_00400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L29_00405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L29_00415	COG1862	Preprotein translocase
I6L29_00455	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6L29_00470	COG0726	polysaccharide deacetylase
I6L29_00485	COG1216	Glycosyl transferase, family 2
I6L29_00535	COG0625	glutathione transferase activity
I6L29_00540	COG0583	DNA-binding transcription factor activity
I6L29_00545	COG1960	acyl-CoA dehydrogenase activity
I6L29_00550	COG1960	acyl-CoA dehydrogenase activity
I6L29_00560	COG2205	protein histidine kinase activity
I6L29_00565	COG0745	RESPONSE REGULATOR receiver
I6L29_00575	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6L29_00595	COG2096	Adenosyltransferase
I6L29_00600	COG4206	TonB-dependent receptor
I6L29_00645	COG0285	dihydrofolate synthase activity
I6L29_00665	COG0450	alkyl hydroperoxide reductase
I6L29_00680	COG0477	Major facilitator Superfamily
I6L29_00685	COG1272	protein, Hemolysin III
I6L29_00695	COG2153	protein acetylation
I6L29_00715	COG0183	Belongs to the thiolase family
I6L29_00720	COG2207	Transcriptional regulator
I6L29_00740	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L29_00760	COG0183	Belongs to the thiolase family
I6L29_00770	COG2885	chlorophyll binding
I6L29_00770	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6L29_00780	COG1690	Belongs to the RtcB family
I6L29_00785	COG0833	amino acid
I6L29_00795	COG2233	PERMEase
I6L29_00800	COG1217	gtp-binding protein TYPA
I6L29_00825	COG2094	Belongs to the DNA glycosylase MPG family
I6L29_00830	COG4772	TonB-dependent receptor
I6L29_00835	COG1902	pentaerythritol trinitrate reductase activity
I6L29_00850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L29_00855	COG0354	folic acid binding
I6L29_00875	COG2233	PERMEase
I6L29_00880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L29_00885	COG0251	oxidation-reduction process
I6L29_00890	COG1335	isochorismatase
I6L29_00895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L29_00905	COG0596	Alpha beta hydrolase
I6L29_00915	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L29_00920	COG3422	double-strand break repair
I6L29_00960	COG0840	transmembrane signaling receptor activity
I6L29_00980	COG5510	response to toxic substance
I6L29_00990	COG2832	Protein of unknown function (DUF454)
I6L29_00995	COG1376	ErfK ybiS ycfS ynhG family protein
I6L29_01035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L29_01045	COG1289	transmembrane transporter activity
I6L29_01050	COG2814	Major facilitator Superfamily
I6L29_01070	COG1115	amino acid carrier protein
I6L29_01075	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L29_01080	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L29_01085	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6L29_01090	COG3590	peptidase
I6L29_01100	COG5342	invasion associated locus B
I6L29_01115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6L29_01125	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6L29_01130	COG1077	Cell shape determining protein MreB Mrl
I6L29_01135	COG1792	Involved in formation and maintenance of cell shape
I6L29_01140	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6L29_01145	COG0424	maF-like protein
I6L29_01150	COG1530	ribonuclease E activity
I6L29_01160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L29_01180	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L29_01205	COG2207	Transcriptional regulator
I6L29_01235	COG3046	protein related to deoxyribodipyrimidine photolyase
I6L29_01245	COG1113	amino acid transport
I6L29_01250	COG2828	Protein conserved in bacteria
I6L29_01255	COG0142	geranyltranstransferase activity
I6L29_01260	COG2315	Protein conserved in bacteria
I6L29_01275	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L29_01300	COG2194	sulfuric ester hydrolase activity
I6L29_01305	COG0745	RESPONSE REGULATOR receiver
I6L29_01310	COG0642	Histidine kinase
I6L29_01325	COG0004	ammonium transporteR
I6L29_01330	COG0583	DNA-binding transcription factor activity
I6L29_01350	COG0525	valine-tRNA ligase activity
I6L29_01360	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_01370	COG0393	Putative heavy-metal-binding
I6L29_01375	COG0393	Putative heavy-metal-binding
I6L29_01380	COG1538	Outer membrane efflux protein
I6L29_01390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L29_01395	COG0671	phosphoesterase, PA-phosphatase related
I6L29_01420	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6L29_01435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L29_01435	COG1648	precorrin-2 dehydrogenase activity
I6L29_01440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6L29_01475	COG0531	amino acid
I6L29_01490	COG0321	lipoyl(octanoyl) transferase activity
I6L29_01495	COG2921	Belongs to the UPF0250 family
I6L29_01535	COG2009	succinate dehydrogenase
I6L29_01540	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6L29_01545	COG1053	succinate dehydrogenase
I6L29_01550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L29_01575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L29_01595	COG2354	Protein conserved in bacteria
I6L29_01600	COG2321	neutral zinc metallopeptidase
I6L29_01620	COG2843	Capsule synthesis protein
I6L29_01640	COG0589	response to stress
I6L29_01650	COG0251	oxidation-reduction process
I6L29_01655	COG1309	transcriptional regulator
I6L29_01670	COG0505	Belongs to the CarA family
I6L29_01700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L29_01705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6L29_01745	COG2264	protein methyltransferase activity
I6L29_01755	COG0477	Major facilitator Superfamily
I6L29_01760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6L29_01775	COG1597	lipid kinase activity
I6L29_01780	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6L29_01805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L29_01810	COG0584	glycerophosphoryl diester phosphodiesterase
I6L29_01830	COG0741	lytic transglycosylase activity
I6L29_01850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L29_01855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L29_01885	COG1309	transcriptional regulator
I6L29_01890	COG1902	pentaerythritol trinitrate reductase activity
I6L29_01895	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L29_01895	COG0596	Alpha beta hydrolase
I6L29_01900	COG0596	Alpha beta hydrolase
I6L29_01900	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L29_01905	COG0596	Alpha beta hydrolase
I6L29_01910	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_01920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L29_01930	COG0778	Nitroreductase
I6L29_01945	COG1929	Belongs to the glycerate kinase type-1 family
I6L29_01950	COG0243	molybdopterin cofactor binding
I6L29_01955	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6L29_01970	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6L29_01985	COG1115	amino acid carrier protein
I6L29_01990	COG1113	amino acid transport
I6L29_02000	COG0019	diaminopimelate decarboxylase activity
I6L29_02010	COG1280	lysine exporter protein (LysE YggA)
I6L29_02015	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6L29_02045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L29_02075	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L29_02080	COG1136	(ABC) transporter
I6L29_02085	COG2333	competence protein COMEC
I6L29_02085	COG0658	competence protein
I6L29_02095	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L29_02095	COG0616	signal peptide processing
I6L29_02100	COG0596	Alpha beta hydrolase
I6L29_02105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L29_02115	COG0628	permease
I6L29_02150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L29_02170	COG0823	Involved in the tonB-independent uptake of proteins
I6L29_02190	COG0824	Thioesterase
I6L29_02195	COG1473	amidohydrolase
I6L29_02215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L29_02215	COG0047	phosphoribosylformylglycinamidine synthase activity
I6L29_02220	COG2814	Major facilitator Superfamily
I6L29_02225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L29_02230	COG1024	Enoyl-CoA hydratase
I6L29_02235	COG1051	belongs to the nudix hydrolase family
I6L29_02235	COG1056	cytidyltransferase-related domain
I6L29_02250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6L29_02265	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6L29_02280	COG4625	pathogenesis
I6L29_02285	COG0583	DNA-binding transcription factor activity
I6L29_02290	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L29_02295	COG4208	sulfate ABC transporter
I6L29_02300	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6L29_02310	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L29_02315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L29_02320	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L29_02340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L29_02350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L29_02355	COG0481	GTPase activity
I6L29_02360	COG0681	Belongs to the peptidase S26 family
I6L29_02370	COG0571	ribonuclease III activity
I6L29_02375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6L29_02385	COG1381	Involved in DNA repair and RecF pathway recombination
I6L29_02390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6L29_02400	COG4221	oxidoreductase activity
I6L29_02430	COG0436	Aminotransferase
I6L29_02450	COG0556	nucleotide-excision repair
I6L29_02460	COG2962	Rard protein
I6L29_02505	COG2070	2-Nitropropane dioxygenase
I6L29_02520	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6L29_02535	COG1215	transferase activity, transferring glycosyl groups
I6L29_02550	COG0415	Belongs to the DNA photolyase family
I6L29_02560	COG1252	NADH dehydrogenase
I6L29_02565	COG1686	Belongs to the peptidase S11 family
I6L29_02580	COG1187	pseudouridine synthase activity
I6L29_02595	COG0477	Major facilitator Superfamily
I6L29_02600	COG0583	DNA-binding transcription factor activity
I6L29_02605	COG1823	symporter activity
I6L29_02615	COG0612	Peptidase, M16
I6L29_02640	COG0352	thiamine-phosphate diphosphorylase activity
I6L29_02675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L29_02690	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L29_02695	COG0076	glutamate decarboxylase activity
I6L29_02705	COG1522	sequence-specific DNA binding
I6L29_02710	COG3961	Belongs to the TPP enzyme family
I6L29_02715	COG1113	amino acid transport
I6L29_02720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6L29_02725	COG0573	inorganic phosphate transmembrane transporter activity
I6L29_02735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L29_02740	COG0616	signal peptide processing
I6L29_02780	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L29_02785	COG1686	Belongs to the peptidase S11 family
I6L29_02810	COG0583	DNA-binding transcription factor activity
I6L29_02815	COG1067	ATP-dependent peptidase activity
I6L29_02820	COG2211	Major facilitator Superfamily
I6L29_02855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6L29_02860	COG1966	Carbon starvation protein
I6L29_02865	COG2879	small protein
I6L29_02895	COG1741	Belongs to the pirin family
I6L29_02910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L29_02915	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L29_02920	COG4605	iron ion homeostasis
I6L29_02925	COG4604	ABC transporter, ATP-binding protein
I6L29_02930	COG4607	ABC-type enterochelin transport system periplasmic component
I6L29_02935	COG4774	siderophore transport
I6L29_02945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L29_02950	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6L29_02955	COG1535	isochorismatase
I6L29_02955	COG3433	isochorismatase activity
I6L29_02970	COG1132	(ABC) transporter
I6L29_02975	COG1132	(ABC) transporter
I6L29_02980	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6L29_02985	COG2977	Belongs to the P-Pant transferase superfamily
I6L29_02990	COG1169	isochorismate synthase
I6L29_03005	COG3739	integral membrane protein
I6L29_03025	COG0302	gtp cyclohydrolase
I6L29_03035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L29_03045	COG2840	Smr protein MutS2
I6L29_03070	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L29_03085	COG0174	glutamine synthetase
I6L29_03095	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6L29_03130	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L29_03135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L29_03140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L29_03160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L29_03165	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6L29_03170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6L29_03185	COG1960	acyl-CoA dehydrogenase activity
I6L29_03190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L29_03195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L29_03205	COG2223	nitrite transmembrane transporter activity
I6L29_03215	COG0024	Methionine aminopeptidase
I6L29_03220	COG0052	Belongs to the universal ribosomal protein uS2 family
I6L29_03235	COG2207	Transcriptional regulator
I6L29_03260	COG2951	lytic endotransglycosylase activity
I6L29_03265	COG0772	Belongs to the SEDS family
I6L29_03280	COG0842	Transport permease protein
I6L29_03285	COG1131	(ABC) transporter
I6L29_03330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L29_03340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L29_03345	COG4215	(ABC) transporter
I6L29_03350	COG4160	amino acid transport
I6L29_03355	COG4598	ABC transporter
I6L29_03365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L29_03370	COG0826	peptidase U32
I6L29_03375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L29_03380	COG0384	phenazine biosynthesis protein PhzF
I6L29_03390	COG1720	tRNA m6t6A37 methyltransferase activity
I6L29_03400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L29_03415	COG0642	Histidine kinase
I6L29_03425	COG0494	nUDIX hydrolase
I6L29_03435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L29_03440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6L29_03445	COG3139	Protein of unknown function (DUF1315)
I6L29_03450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L29_03455	COG1301	dicarboxylic acid transport
I6L29_03460	COG1960	acyl-CoA dehydrogenase activity
I6L29_03480	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6L29_03490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L29_03495	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L29_03515	COG1690	Belongs to the RtcB family
I6L29_03520	COG1234	tRNA 3'-trailer cleavage
I6L29_03525	COG4650	regulator
I6L29_03555	COG2363	Small membrane protein
I6L29_03575	COG0513	Belongs to the DEAD box helicase family
I6L29_03585	COG0778	Nitroreductase
I6L29_03615	COG1286	toxin biosynthetic process
I6L29_03640	COG4783	chaperone-mediated protein folding
I6L29_03645	COG1610	YqeY-like protein
I6L29_03675	COG0515	serine threonine protein kinase
I6L29_03675	COG2815	serine threonine protein kinase
I6L29_03700	COG1278	Cold shock
I6L29_03715	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6L29_03720	COG0786	glutamate:sodium symporter activity
I6L29_03725	COG0475	glutathione-regulated potassium exporter activity
I6L29_03725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L29_03740	COG1309	transcriptional regulator
I6L29_03750	COG2985	domain, Protein
I6L29_03760	COG2995	paraquat-inducible protein a
I6L29_03765	COG3008	intermembrane lipid transfer
I6L29_03765	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L29_03775	COG2351	hydroxyisourate hydrolase activity
I6L29_03815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L29_03825	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L29_03830	COG0642	Histidine kinase
I6L29_03835	COG0745	RESPONSE REGULATOR receiver
I6L29_03850	COG1794	racemase activity, acting on amino acids and derivatives
I6L29_03880	COG1301	dicarboxylic acid transport
I6L29_03890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L29_03895	COG2011	ABC-type metal ion transport system permease component
I6L29_03900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L29_03910	COG0151	Belongs to the GarS family
I6L29_03920	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6L29_03950	COG2308	Evidence 4 Homologs of previously reported genes of
I6L29_03960	COG1305	Transglutaminase-like
I6L29_03970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L29_03975	COG0305	Participates in initiation and elongation during chromosome replication
I6L29_04000	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6L29_04005	COG1845	cytochrome c oxidase, subunit III
I6L29_04010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6L29_04040	COG1649	PFAM Uncharacterised BCR, COG1649
I6L29_04040	COG0726	polysaccharide deacetylase
I6L29_04045	COG1215	transferase activity, transferring glycosyl groups
I6L29_04050	COG3658	cytochrome
I6L29_04060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L29_04075	COG0583	DNA-binding transcription factor activity
I6L29_04090	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L29_04095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L29_04100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L29_04115	COG1960	acyl-CoA dehydrogenase activity
I6L29_04120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L29_04135	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6L29_04145	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6L29_04150	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6L29_04160	COG2205	protein histidine kinase activity
I6L29_04165	COG0745	RESPONSE REGULATOR receiver
I6L29_04170	COG0174	glutamine synthetase
I6L29_04190	COG0729	surface antigen
I6L29_04220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L29_04225	COG2814	Major facilitator Superfamily
I6L29_04235	COG0583	DNA-binding transcription factor activity
I6L29_04250	COG1187	pseudouridine synthase activity
I6L29_04270	COG0802	atpase or kinase
I6L29_04275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L29_04285	COG1923	regulation of RNA biosynthetic process
I6L29_04290	COG0697	spore germination
I6L29_04300	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L29_04315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L29_04315	COG0519	Catalyzes the synthesis of GMP from XMP
I6L29_04320	COG4302	ethanolamine ammonia-lyase activity
I6L29_04325	COG4303	Ethanolamine ammonia lyase large subunit
I6L29_04330	COG0531	amino acid
I6L29_04350	COG1454	alcohol dehydrogenase
I6L29_04355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L29_04380	COG0308	aminopeptidase N
I6L29_04420	COG1605	Chorismate mutase
I6L29_04435	COG4772	TonB-dependent receptor
I6L29_04440	COG4774	siderophore transport
I6L29_04490	COG3772	lysozyme
I6L29_04515	COG0583	DNA-binding transcription factor activity
I6L29_04550	COG0488	(ABC) transporter
I6L29_04555	COG0589	response to stress
I6L29_04575	COG3135	benzoate transporter
I6L29_04580	COG1522	sequence-specific DNA binding
I6L29_04590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L29_04595	COG0583	DNA-binding transcription factor activity
I6L29_04605	COG0183	Belongs to the thiolase family
I6L29_04610	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_04615	COG2030	dehydratase
I6L29_04620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L29_04645	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6L29_04660	COG0824	Thioesterase
I6L29_04665	COG1454	alcohol dehydrogenase
I6L29_04680	COG1335	isochorismatase
I6L29_04695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6L29_04725	COG0069	glutamate synthase activity
I6L29_04750	COG2814	Major facilitator Superfamily
I6L29_04765	COG0511	ligase activity, forming carbon-carbon bonds
I6L29_04790	COG4264	IucA IucC family
I6L29_04800	COG4264	IucA IucC family
I6L29_04805	COG2423	ornithine cyclodeaminase activity
I6L29_04810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L29_04820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L29_04820	COG1116	anion transmembrane transporter activity
I6L29_04835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L29_04835	COG2146	nitrite reductase [NAD(P)H] activity
I6L29_04840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L29_04845	COG0243	molybdopterin cofactor binding
I6L29_04855	COG0243	molybdopterin cofactor binding
I6L29_04860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6L29_04875	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L29_04875	COG0315	cyclic pyranopterin monophosphate synthase activity
I6L29_04880	COG0303	'Molybdopterin
I6L29_04890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L29_04895	COG0697	spore germination
I6L29_04920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L29_04990	COG2204	response regulator
I6L29_04995	COG3852	Histidine kinase
I6L29_05020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L29_05025	COG0575	Belongs to the CDS family
I6L29_05060	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L29_05075	COG2137	regulation of response to DNA damage stimulus
I6L29_05085	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6L29_05090	COG1011	Hydrolase
I6L29_05105	COG1522	sequence-specific DNA binding
I6L29_05115	COG1113	amino acid transport
I6L29_05120	COG0657	acetylesterase activity
I6L29_05135	COG0659	secondary active sulfate transmembrane transporter activity
I6L29_05170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L29_05170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L29_05170	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6L29_05175	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L29_05180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L29_05180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L29_05210	COG0024	Methionine aminopeptidase
I6L29_05215	COG0583	DNA-binding transcription factor activity
I6L29_05225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6L29_05230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L29_05235	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L29_05235	COG0517	IMP dehydrogenase activity
I6L29_05260	COG0552	protein localization to endoplasmic reticulum
I6L29_05285	COG4890	Cyd operon protein YbgT
I6L29_05290	COG1294	oxidase, subunit
I6L29_05305	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L29_05315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L29_05330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L29_05335	COG0569	domain protein
I6L29_05340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L29_05370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6L29_05375	COG0542	response to heat
I6L29_05400	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L29_05400	COG1902	pentaerythritol trinitrate reductase activity
I6L29_05440	COG0148	phosphopyruvate hydratase activity
I6L29_05445	COG2323	membrane
I6L29_05455	COG4773	Receptor
I6L29_05460	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6L29_05470	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L29_05475	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L29_05480	COG0183	Belongs to the thiolase family
I6L29_05485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6L29_05490	COG0596	Alpha beta hydrolase
I6L29_05495	COG2271	Major facilitator Superfamily
I6L29_05500	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L29_05505	COG3485	protocatechuate 3,4-dioxygenase
I6L29_05510	COG3485	protocatechuate 3,4-dioxygenase
I6L29_05515	COG0710	3-dehydroquinate dehydratase activity
I6L29_05520	COG3420	alginic acid biosynthetic process
I6L29_05525	COG3659	wide pore channel activity
I6L29_05530	COG4993	Dehydrogenase
I6L29_05635	COG2369	cell adhesion
I6L29_05640	COG4383	Mu-like prophage protein gp29
I6L29_05660	COG4373	Mu-like prophage FluMu protein gp28
I6L29_05730	COG3409	Peptidoglycan-binding domain 1 protein
I6L29_05730	COG3267	Type II secretory pathway component ExeA
I6L29_05755	COG0776	regulation of translation
I6L29_05805	COG2391	methyltransferase activity
I6L29_05820	COG1414	Transcriptional regulator
I6L29_05825	COG0583	DNA-binding transcription factor activity
I6L29_05830	COG1960	acyl-CoA dehydrogenase activity
I6L29_05855	COG2814	Major facilitator Superfamily
I6L29_05865	COG0154	amidase activity
I6L29_05895	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_05905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L29_05915	COG3733	amine oxidase
I6L29_05925	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_05930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L29_05935	COG0183	Belongs to the thiolase family
I6L29_05940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L29_05945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L29_05955	COG4829	muconolactone delta-isomerase
I6L29_05960	COG4948	Mandelate Racemase Muconate Lactonizing
I6L29_05965	COG0583	DNA-binding transcription factor activity
I6L29_05975	COG2186	Transcriptional regulator
I6L29_05995	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_06000	COG2351	hydroxyisourate hydrolase activity
I6L29_06005	COG2233	PERMEase
I6L29_06015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L29_06020	COG2186	Transcriptional regulator
I6L29_06030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L29_06040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L29_06060	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L29_06060	COG1902	pentaerythritol trinitrate reductase activity
I6L29_06100	COG1309	transcriptional regulator
I6L29_06105	COG0583	DNA-binding transcription factor activity
I6L29_06110	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_06115	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_06120	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_06130	COG1960	acyl-CoA dehydrogenase activity
I6L29_06140	COG0318	PFAM AMP-dependent synthetase and ligase
I6L29_06215	COG0583	DNA-binding transcription factor activity
I6L29_06240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L29_06245	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L29_06260	COG2831	hemolysin activation secretion protein
I6L29_06265	COG3210	domain, Protein
I6L29_06320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L29_06325	COG1120	ATPase activity
I6L29_06345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L29_06395	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6L29_06440	COG3539	Fimbrial protein
I6L29_06465	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6L29_06475	COG0753	catalase activity
I6L29_06495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L29_06505	COG2205	protein histidine kinase activity
I6L29_06510	COG0745	RESPONSE REGULATOR receiver
I6L29_06515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L29_06520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L29_06575	COG1535	isochorismatase
I6L29_06575	COG3433	isochorismatase activity
I6L29_06580	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_06660	COG4397	Mu-like prophage major head subunit gpT
I6L29_06675	COG5005	Phage virion morphogenesis
I6L29_06685	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6L29_06690	COG4149	molybdate abc transporter
I6L29_06695	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6L29_06705	COG4638	Rieske (2fe-2S)
I6L29_06710	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6L29_06715	COG0543	2 iron, 2 sulfur cluster binding
I6L29_06715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L29_06730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L29_06740	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_06760	COG2207	Transcriptional regulator
I6L29_06765	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_06770	COG2610	gluconate transmembrane transporter activity
I6L29_06810	COG0583	DNA-binding transcription factor activity
I6L29_06825	COG2031	fatty acid transporter
I6L29_06830	COG0183	Belongs to the thiolase family
I6L29_06835	COG0583	DNA-binding transcription factor activity
I6L29_06840	COG0583	DNA-binding transcription factor activity
I6L29_06855	COG1027	Aspartate ammonia-lyase
I6L29_06865	COG0477	Major facilitator Superfamily
I6L29_06875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L29_06880	COG1733	regulation of RNA biosynthetic process
I6L29_06885	COG2207	Transcriptional regulator
I6L29_06885	COG3708	Transcriptional regulator
I6L29_06900	COG0730	response to heat
I6L29_06905	COG3453	Protein conserved in bacteria
I6L29_06905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L29_06920	COG3781	membrane
I6L29_06925	COG1063	alcohol dehydrogenase
I6L29_06935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L29_06940	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L29_06945	COG0022	dehydrogenase e1 component
I6L29_06950	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6L29_06955	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L29_06970	COG3706	GGDEF domain
I6L29_06990	COG0133	tryptophan synthase activity
I6L29_07000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L29_07030	COG0583	DNA-binding transcription factor activity
I6L29_07035	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L29_07040	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6L29_07045	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6L29_07105	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L29_07110	COG4773	Receptor
I6L29_07135	COG0730	response to heat
I6L29_07140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L29_07160	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6L29_07175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L29_07185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6L29_07200	COG1960	acyl-CoA dehydrogenase activity
I6L29_07205	COG1960	acyl-CoA dehydrogenase activity
I6L29_07210	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L29_07215	COG2207	Transcriptional regulator
I6L29_07220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L29_07225	COG0776	regulation of translation
I6L29_07250	COG0822	iron-sulfur transferase activity
I6L29_07255	COG0316	Belongs to the HesB IscA family
I6L29_07285	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L29_07305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L29_07310	COG0702	epimerase
I6L29_07345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L29_07350	COG0601	transmembrane transport
I6L29_07355	COG0339	signal peptide processing
I6L29_07360	COG4166	transmembrane transport
I6L29_07405	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L29_07410	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6L29_07425	COG2431	L-lysine efflux transmembrane transporter activity
I6L29_07440	COG0776	regulation of translation
I6L29_07505	COG0084	hydrolase, TatD family'
I6L29_07525	COG1663	tetraacyldisaccharide 4'-kinase activity
I6L29_07530	COG1132	(ABC) transporter
I6L29_07540	COG0811	peptide transport
I6L29_07545	COG1475	DNA binding
I6L29_07550	COG1192	Involved in chromosome partitioning
I6L29_07560	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6L29_07565	COG3178	'Phosphotransferase
I6L29_07575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L29_07600	COG0424	maF-like protein
I6L29_07605	COG2850	peptidyl-arginine hydroxylation
I6L29_07615	COG0640	Transcriptional regulator
I6L29_07625	COG3619	membrane
I6L29_07630	COG3122	Protein conserved in bacteria
I6L29_07635	COG1132	(ABC) transporter
I6L29_07655	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6L29_07660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L29_07670	COG0506	proline dehydrogenase activity
I6L29_07670	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L29_07670	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L29_07675	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6L29_07690	COG3698	Phosphodiester glycosidase
I6L29_07700	COG2353	YceI-like domain
I6L29_07710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L29_07755	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6L29_07755	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L29_07780	COG3539	Fimbrial protein
I6L29_07815	COG0583	DNA-binding transcription factor activity
I6L29_07820	COG0697	spore germination
I6L29_07830	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6L29_07840	COG0583	DNA-binding transcription factor activity
I6L29_07855	COG1309	transcriptional regulator
I6L29_07870	COG1522	sequence-specific DNA binding
I6L29_07880	COG1126	abc transporter atp-binding protein
I6L29_07885	COG0765	amino acid transport
I6L29_07890	COG0765	amino acid transport
I6L29_07920	COG1464	Belongs to the NlpA lipoprotein family
I6L29_07925	COG1464	Belongs to the NlpA lipoprotein family
I6L29_07930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L29_07935	COG2011	ABC-type metal ion transport system permease component
I6L29_07940	COG0012	GTP binding
I6L29_07965	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6L29_08000	COG1917	Cupin 2, conserved barrel domain protein
I6L29_08000	COG2207	Transcriptional regulator
I6L29_08005	COG0386	Belongs to the glutathione peroxidase family
I6L29_08015	COG0436	Aminotransferase
I6L29_08020	COG1301	dicarboxylic acid transport
I6L29_08055	COG3634	alkyl hydroperoxide reductase activity
I6L29_08070	COG0583	DNA-binding transcription factor activity
I6L29_08075	COG0431	NADPH-dependent FMN reductase
I6L29_08080	COG0798	PFAM Bile acid sodium symporter
I6L29_08090	COG0640	Transcriptional regulator
I6L29_08105	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6L29_08115	COG0583	DNA-binding transcription factor activity
I6L29_08125	COG1953	Uracil, thiamine, allantoin
I6L29_08135	COG2175	clavaminate synthase activity
I6L29_08140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L29_08145	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6L29_08150	COG4521	taurine ABC transporter
I6L29_08160	COG0477	Major facilitator Superfamily
I6L29_08180	COG1271	oxidase subunit
I6L29_08185	COG1294	oxidase, subunit
I6L29_08195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L29_08215	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6L29_08235	COG3052	prosthetic group binding
I6L29_08240	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6L29_08265	COG1346	cytolysis
I6L29_08275	COG0583	DNA-binding transcription factor activity
I6L29_08280	COG0625	glutathione transferase activity
I6L29_08285	COG0625	glutathione transferase activity
I6L29_08290	COG0583	DNA-binding transcription factor activity
I6L29_08295	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_08305	COG1045	serine acetyltransferase
I6L29_08310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L29_08315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6L29_08325	COG1280	lysine exporter protein (LysE YggA)
I6L29_08340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L29_08345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L29_08355	COG0765	amino acid transport
I6L29_08360	COG0765	amino acid transport
I6L29_08380	COG0784	Response regulator, receiver
I6L29_08380	COG2205	protein histidine kinase activity
I6L29_08400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L29_08420	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_08465	COG0583	DNA-binding transcription factor activity
I6L29_08475	COG2814	Major facilitator Superfamily
I6L29_08490	COG0318	PFAM AMP-dependent synthetase and ligase
I6L29_08495	COG1309	transcriptional regulator
I6L29_08500	COG1960	acyl-CoA dehydrogenase activity
I6L29_08505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L29_08510	COG1024	Enoyl-CoA hydratase
I6L29_08515	COG4770	biotin carboxylase activity
I6L29_08525	COG0583	DNA-binding transcription factor activity
I6L29_08540	COG1960	acyl-CoA dehydrogenase activity
I6L29_08550	COG2814	Major facilitator Superfamily
I6L29_08560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L29_08565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L29_08570	COG2814	Major facilitator Superfamily
I6L29_08575	COG1960	acyl-CoA dehydrogenase activity
I6L29_08580	COG1024	Enoyl-CoA hydratase
I6L29_08590	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L29_08595	COG0183	Belongs to the thiolase family
I6L29_08605	COG2814	Major facilitator Superfamily
I6L29_08615	COG1024	Enoyl-CoA hydratase
I6L29_08625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6L29_08630	COG1960	acyl-CoA dehydrogenase activity
I6L29_08635	COG2814	Major facilitator Superfamily
I6L29_08640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L29_08645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6L29_08660	COG3842	ATPase activity
I6L29_08665	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L29_08680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L29_08685	COG1414	Transcriptional regulator
I6L29_08695	COG0583	DNA-binding transcription factor activity
I6L29_08700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L29_08705	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_08715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6L29_08725	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_08730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L29_08735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L29_08740	COG2267	carboxylic ester hydrolase activity
I6L29_08785	COG2050	protein possibly involved in aromatic compounds catabolism
I6L29_08795	COG3327	negative regulation of DNA-templated transcription, initiation
I6L29_08800	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6L29_08805	COG0183	Belongs to the thiolase family
I6L29_08810	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L29_08815	COG1024	Enoyl-CoA hydratase
I6L29_08820	COG1024	Enoyl-CoA hydratase
I6L29_08825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L29_08830	COG2151	metal-sulfur cluster biosynthetic enzyme
I6L29_08835	COG3396	Phenylacetate-CoA oxygenase
I6L29_08840	COG3460	Phenylacetate-CoA oxygenase
I6L29_08845	COG3396	Phenylacetate-CoA oxygenase
I6L29_08850	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_08850	COG2030	dehydratase
I6L29_08855	COG1760	l-serine dehydratase
I6L29_08870	COG0789	Transcriptional regulator
I6L29_08880	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6L29_08885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L29_08900	COG2807	transmembrane transport
I6L29_08905	COG0590	tRNA wobble adenosine to inosine editing
I6L29_08910	COG0666	response to abiotic stimulus
I6L29_08955	COG2885	chlorophyll binding
I6L29_08975	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L29_09005	COG3210	domain, Protein
I6L29_09010	COG2831	hemolysin activation secretion protein
I6L29_09015	COG0038	chloride channel
I6L29_09020	COG4770	biotin carboxylase activity
I6L29_09040	COG1914	H( )-stimulated, divalent metal cation uptake system
I6L29_09045	COG0583	DNA-binding transcription factor activity
I6L29_09055	COG1595	DNA-templated transcription, initiation
I6L29_09065	COG3220	belongs to the UPF0276 family
I6L29_09115	COG0702	epimerase
I6L29_09120	COG1733	regulation of RNA biosynthetic process
I6L29_09130	COG1234	tRNA 3'-trailer cleavage
I6L29_09135	COG1051	belongs to the nudix hydrolase family
I6L29_09150	COG3712	iron ion homeostasis
I6L29_09200	COG3038	cytochrome b561
I6L29_09205	COG0753	catalase activity
I6L29_09210	COG1733	regulation of RNA biosynthetic process
I6L29_09235	COG0531	amino acid
I6L29_09240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L29_09255	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L29_09270	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6L29_09280	COG4122	O-methyltransferase activity
I6L29_09310	COG1538	Outer membrane efflux protein
I6L29_09315	COG1137	ATPase activity
I6L29_09320	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6L29_09330	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6L29_09355	COG0668	transmembrane transport
I6L29_09400	COG1309	transcriptional regulator
I6L29_09430	COG2226	methyltransferase
I6L29_09455	COG1278	Cold shock
I6L29_09460	COG1560	Kdo2-lipid A biosynthetic process
I6L29_09465	COG1280	lysine exporter protein (LysE YggA)
I6L29_09500	COG1570	exodeoxyribonuclease VII activity
I6L29_09585	COG2871	sodium ion transport
I6L29_09595	COG0583	DNA-binding transcription factor activity
I6L29_09605	COG4638	Rieske (2fe-2S)
I6L29_09610	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6L29_09615	COG0543	2 iron, 2 sulfur cluster binding
I6L29_09615	COG0633	Ferredoxin
I6L29_09620	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_09625	COG3135	benzoate transporter
I6L29_09630	COG2814	Major facilitator Superfamily
I6L29_09645	COG1643	Atp-dependent helicase
I6L29_09670	COG3634	alkyl hydroperoxide reductase activity
I6L29_09690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6L29_09710	COG0625	glutathione transferase activity
I6L29_09720	COG2885	chlorophyll binding
I6L29_09755	COG0542	response to heat
I6L29_09770	COG1765	OsmC-like protein
I6L29_09785	COG0667	Aldo Keto reductase
I6L29_09800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6L29_09815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L29_09825	COG0582	viral genome integration into host DNA
I6L29_09840	COG3293	Transposase
I6L29_09845	COG1063	alcohol dehydrogenase
I6L29_09895	COG0741	lytic transglycosylase activity
I6L29_09895	COG0739	heme binding
I6L29_09895	COG1196	nuclear chromosome segregation
I6L29_09910	COG1598	PFAM Uncharacterised protein family UPF0150
I6L29_10190	COG0527	aspartate kinase activity
I6L29_10200	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6L29_10210	COG3038	cytochrome b561
I6L29_10215	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L29_10220	COG2252	PERMEase
I6L29_10230	COG1741	Belongs to the pirin family
I6L29_10235	COG1309	transcriptional regulator
I6L29_10250	COG2072	flavoprotein involved in K transport
I6L29_10255	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6L29_10260	COG0583	DNA-binding transcription factor activity
I6L29_10275	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L29_10305	COG1944	ATP diphosphatase activity
I6L29_10325	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L29_10340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L29_10355	COG2814	Major facilitator Superfamily
I6L29_10360	COG1024	Enoyl-CoA hydratase
I6L29_10365	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_10375	COG1960	acyl-CoA dehydrogenase activity
I6L29_10400	COG2186	Transcriptional regulator
I6L29_10405	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_10415	COG4948	Mandelate Racemase Muconate Lactonizing
I6L29_10420	COG2271	Major facilitator Superfamily
I6L29_10425	COG2721	sulfolactate sulfo-lyase activity
I6L29_10430	COG0697	spore germination
I6L29_10450	COG3210	domain, Protein
I6L29_10455	COG2831	hemolysin activation secretion protein
I6L29_10460	COG1113	amino acid transport
I6L29_10480	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_10500	COG0531	amino acid
I6L29_10510	COG1113	amino acid transport
I6L29_10550	COG4269	membrane
I6L29_10570	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L29_10570	COG1902	pentaerythritol trinitrate reductase activity
I6L29_10580	COG2203	Gaf domain
I6L29_10580	COG3706	GGDEF domain
I6L29_10580	COG4251	negative regulation of phosphorylation
I6L29_10580	COG5001	Diguanylate cyclase
I6L29_10590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L29_10615	COG4172	Belongs to the ABC transporter superfamily
I6L29_10620	COG4239	(ABC) transporter, permease
I6L29_10625	COG4174	ABC transporter (Permease)
I6L29_10630	COG4166	transmembrane transport
I6L29_10635	COG0741	lytic transglycosylase activity
I6L29_10635	COG1388	LysM domain
I6L29_10635	COG1388	LysM domain
I6L29_10635	COG0741	lytic transglycosylase activity
I6L29_10680	COG0583	DNA-binding transcription factor activity
I6L29_10685	COG1279	arginine transmembrane transporter activity
I6L29_10695	COG0789	Transcriptional regulator
I6L29_10705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L29_10710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L29_10715	COG0006	proline dipeptidase activity
I6L29_10755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L29_10770	COG3384	dioxygenase
I6L29_10780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L29_10785	COG2878	Part of a membrane complex involved in electron transport
I6L29_10790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L29_10815	COG0768	penicillin binding
I6L29_10820	COG0742	ribosomal rna small subunit methyltransferase
I6L29_10835	COG0830	nickel cation binding
I6L29_10845	COG0804	urea catabolic process
I6L29_10870	COG3015	lipoprotein NlpE involved in copper resistance
I6L29_10885	COG1253	flavin adenine dinucleotide binding
I6L29_10890	COG2851	Citrate transporter
I6L29_10940	COG1773	rubredoxin
I6L29_10945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L29_10950	COG2267	carboxylic ester hydrolase activity
I6L29_10955	COG0583	DNA-binding transcription factor activity
I6L29_10985	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6L29_10990	COG4181	ATPase activity
I6L29_11035	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L29_11055	COG0306	phosphate transporter
I6L29_11085	COG2223	nitrite transmembrane transporter activity
I6L29_11090	COG2207	Transcriptional regulator
I6L29_11095	COG2066	Belongs to the glutaminase family
I6L29_11100	COG0242	peptide deformylase activity
I6L29_11105	COG0477	Major facilitator Superfamily
I6L29_11115	COG0028	Belongs to the TPP enzyme family
I6L29_11130	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_11135	COG2267	carboxylic ester hydrolase activity
I6L29_11145	COG2271	Major facilitator Superfamily
I6L29_11160	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_11180	COG1414	Transcriptional regulator
I6L29_11195	COG1024	Enoyl-CoA hydratase
I6L29_11205	COG1215	transferase activity, transferring glycosyl groups
I6L29_11210	COG1649	PFAM Uncharacterised BCR, COG1649
I6L29_11210	COG0726	polysaccharide deacetylase
I6L29_11220	COG4681	YaeQ
I6L29_11230	COG0523	cobalamin synthesis protein
I6L29_11240	COG1607	acyl-coa hydrolase
I6L29_11250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L29_11255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L29_11260	COG1309	transcriptional regulator
I6L29_11285	COG2040	homocysteine
I6L29_11290	COG0531	amino acid
I6L29_11340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L29_11345	COG2814	Major facilitator Superfamily
I6L29_11390	COG1401	restriction endodeoxyribonuclease activity
I6L29_11400	COG0405	Gamma-glutamyltransferase
I6L29_11405	COG2814	Major facilitator Superfamily
I6L29_11415	COG2050	protein possibly involved in aromatic compounds catabolism
I6L29_11430	COG1090	epimerase
I6L29_11450	COG0420	3'-5' exonuclease activity
I6L29_11475	COG0735	belongs to the Fur family
I6L29_11480	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L29_11485	COG2914	Belongs to the UPF0125 (RnfH) family
I6L29_11500	COG0121	glutamine amidotransferase
I6L29_11515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L29_11525	COG0210	DNA helicase
I6L29_11530	COG2885	chlorophyll binding
I6L29_11535	COG0204	Acyl-transferase
I6L29_11550	COG2894	cell division
I6L29_11565	COG1280	lysine exporter protein (LysE YggA)
I6L29_11570	COG1674	ftsk spoiiie
I6L29_11575	COG0492	ferredoxin-NADP+ reductase activity
I6L29_11580	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6L29_11590	COG0456	acetyltransferase
I6L29_11605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L29_11610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6L29_11620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6L29_11635	COG1981	membrane
I6L29_11645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L29_11645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6L29_11665	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_11670	COG4638	Rieske (2fe-2S)
I6L29_11675	COG0657	acetylesterase activity
I6L29_11685	COG0473	3-isopropylmalate dehydrogenase activity
I6L29_11690	COG0583	DNA-binding transcription factor activity
I6L29_11710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L29_11745	COG0358	DNA primase activity
I6L29_11760	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6L29_11790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L29_11820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L29_11830	COG0351	phosphomethylpyrimidine kinase
I6L29_11830	COG0352	thiamine-phosphate diphosphorylase activity
I6L29_11830	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6L29_11835	COG1652	LysM domain
I6L29_11860	COG1399	metal-binding, possibly nucleic acid-binding protein
I6L29_11865	COG3101	peptidyl-lysine hydroxylation
I6L29_11870	COG0009	L-threonylcarbamoyladenylate synthase
I6L29_11875	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6L29_11880	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6L29_11895	COG4106	trans-aconitate 2-methyltransferase activity
I6L29_11910	COG0596	Alpha beta hydrolase
I6L29_11910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L29_11910	COG2226	methyltransferase
I6L29_11920	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6L29_11925	COG2223	nitrite transmembrane transporter activity
I6L29_11945	COG1196	nuclear chromosome segregation
I6L29_11955	COG0730	response to heat
I6L29_11970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L29_11980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L29_12030	COG0489	protein tyrosine kinase activity
I6L29_12040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L29_12040	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L29_12075	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6L29_12080	COG2081	HI0933 family
I6L29_12090	COG0668	transmembrane transport
I6L29_12110	COG0583	DNA-binding transcription factor activity
I6L29_12130	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L29_12135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L29_12165	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6L29_12190	COG2199	diguanylate cyclase activity
I6L29_12205	COG0745	RESPONSE REGULATOR receiver
I6L29_12220	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L29_12260	COG0110	maltose O-acetyltransferase activity
I6L29_12265	COG0438	transferase activity, transferring glycosyl groups
I6L29_12275	COG3328	transposase activity
I6L29_12320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L29_12335	COG0583	DNA-binding transcription factor activity
I6L29_12370	COG0583	DNA-binding transcription factor activity
I6L29_12385	COG0583	DNA-binding transcription factor activity
I6L29_12390	COG1053	succinate dehydrogenase
I6L29_12405	COG1309	transcriptional regulator
I6L29_12415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6L29_12420	COG2814	Major facilitator Superfamily
I6L29_12425	COG1960	acyl-CoA dehydrogenase activity
I6L29_12430	COG0583	DNA-binding transcription factor activity
I6L29_12460	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6L29_12465	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6L29_12470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L29_12490	COG2132	Multicopper oxidase
I6L29_12500	COG0561	phosphatase activity
I6L29_12505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L29_12515	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6L29_12530	COG1214	PFAM Peptidase M22, glycoprotease
I6L29_12590	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6L29_12595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6L29_12600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6L29_12660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L29_12670	COG1846	Transcriptional regulator
I6L29_12675	COG1764	response to oxidative stress
I6L29_12715	COG0037	tRNA processing
I6L29_12725	COG0248	Ppx GppA phosphatase
I6L29_12755	COG0072	phenylalanine-tRNA ligase activity
I6L29_12780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6L29_12795	COG1238	metal cluster binding
I6L29_12800	COG0625	glutathione transferase activity
I6L29_12815	COG0318	PFAM AMP-dependent synthetase and ligase
I6L29_12820	COG3028	Belongs to the UPF0307 family
I6L29_12825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L29_12845	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6L29_12850	COG0617	tRNA 3'-terminal CCA addition
I6L29_12855	COG1555	photosystem II stabilization
I6L29_12860	COG3956	TIGRFAM MazG family protein
I6L29_12870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L29_12885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L29_12890	COG0784	Response regulator, receiver
I6L29_12890	COG2205	protein histidine kinase activity
I6L29_12890	COG5002	protein histidine kinase activity
I6L29_12895	COG1024	Enoyl-CoA hydratase
I6L29_12900	COG2084	Dehydrogenase
I6L29_12905	COG3622	Belongs to the hyi family
I6L29_12940	COG0697	spore germination
I6L29_12950	COG2814	Major facilitator Superfamily
I6L29_13000	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L29_13025	COG2132	Multicopper oxidase
I6L29_13040	COG2205	protein histidine kinase activity
I6L29_13125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L29_13140	COG0583	DNA-binding transcription factor activity
I6L29_13150	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6L29_13160	COG0084	hydrolase, TatD family'
I6L29_13175	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6L29_13195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6L29_13200	COG0440	acetolactate synthase activity
I6L29_13205	COG0028	Belongs to the TPP enzyme family
I6L29_13225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L29_13230	COG0577	efflux transmembrane transporter activity
I6L29_13230	COG1136	(ABC) transporter
I6L29_13260	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6L29_13265	COG1162	GTPase activity
I6L29_13275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L29_13295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L29_13315	COG1426	Protein conserved in bacteria
I6L29_13350	COG0793	Belongs to the peptidase S41A family
I6L29_13365	COG2267	carboxylic ester hydrolase activity
I6L29_13375	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_13380	COG3265	gluconokinase activity
I6L29_13390	COG0800	Aldolase
I6L29_13405	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L29_13410	COG0280	phosphate acetyltransferase
I6L29_13410	COG0857	belongs to the CobB CobQ family
I6L29_13415	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L29_13415	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L29_13435	COG0740	serine-type endopeptidase activity
I6L29_13445	COG4774	siderophore transport
I6L29_13455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L29_13465	COG2813	Specifically methylates the guanine in position
I6L29_13465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L29_13565	COG0788	formyltetrahydrofolate deformylase activity
I6L29_13590	COG4651	solute:proton antiporter activity
I6L29_13590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L29_13610	COG0724	RNA recognition motif
I6L29_13615	COG0210	DNA helicase
I6L29_13640	COG1733	regulation of RNA biosynthetic process
I6L29_13645	COG0604	alcohol dehydrogenase
I6L29_13650	COG2900	Belongs to the SlyX family
I6L29_13655	COG0488	(ABC) transporter
I6L29_13665	COG1560	Kdo2-lipid A biosynthetic process
I6L29_13675	COG1301	dicarboxylic acid transport
I6L29_13730	COG0473	3-isopropylmalate dehydrogenase activity
I6L29_13755	COG0583	DNA-binding transcription factor activity
I6L29_13795	COG0583	DNA-binding transcription factor activity
I6L29_13805	COG0625	glutathione transferase activity
I6L29_13810	COG2378	regulation of single-species biofilm formation
I6L29_13815	COG0546	phosphoglycolate phosphatase activity
I6L29_13825	COG1530	ribonuclease E activity
I6L29_13830	COG0318	PFAM AMP-dependent synthetase and ligase
I6L29_13845	COG0583	DNA-binding transcription factor activity
I6L29_13850	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_13855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L29_13865	COG0534	Mate efflux family protein
I6L29_13880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L29_13905	COG0493	'glutamate synthase
I6L29_13905	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L29_13915	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6L29_13920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L29_13935	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6L29_13945	COG0644	oxidoreductase
I6L29_13945	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6L29_13960	COG4535	Mg2 and Co2 transporter CorC
I6L29_13970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L29_13990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L29_14000	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6L29_14010	COG0484	heat shock protein binding
I6L29_14015	COG0789	Transcriptional regulator
I6L29_14020	COG0598	Magnesium transport protein CorA
I6L29_14025	COG1185	polyribonucleotide nucleotidyltransferase activity
I6L29_14035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L29_14040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L29_14045	COG1074	ATP-dependent DNA helicase activity
I6L29_14050	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6L29_14070	COG2226	methyltransferase
I6L29_14080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L29_14085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L29_14095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6L29_14110	COG2111	Na H antiporter
I6L29_14110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L29_14115	COG1006	Multisubunit Na H antiporter MnhC subunit
I6L29_14120	COG0651	ATP synthesis coupled electron transport
I6L29_14125	COG1863	multisubunit Na H antiporter MnhE subunit
I6L29_14130	COG2212	antiporter activity
I6L29_14135	COG1320	monovalent cation:proton antiporter activity
I6L29_14140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6L29_14150	COG0195	Participates in both transcription termination and antitermination
I6L29_14200	COG0237	dephospho-CoA kinase activity
I6L29_14210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L29_14225	COG0497	DNA recombination
I6L29_14235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6L29_14270	COG2169	Transcriptional regulator
I6L29_14270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L29_14275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L29_14345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6L29_14360	COG0326	Molecular chaperone. Has ATPase activity
I6L29_14375	COG2056	Na+-H+ antiporter family
I6L29_14445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L29_14475	COG0546	phosphoglycolate phosphatase activity
I6L29_14480	COG1716	ATPase activity
I6L29_14525	COG0181	hydroxymethylbilane synthase activity
I6L29_14535	COG3275	phosphorelay sensor kinase activity
I6L29_14555	COG1538	Outer membrane efflux protein
I6L29_14565	COG0697	spore germination
I6L29_14585	COG0494	nUDIX hydrolase
I6L29_14590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6L29_14595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L29_14600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L29_14605	COG0772	Belongs to the SEDS family
I6L29_14630	COG4974	Belongs to the 'phage' integrase family
I6L29_14635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L29_14645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L29_14655	COG2197	response regulator
I6L29_14670	COG0793	Belongs to the peptidase S41A family
I6L29_14675	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6L29_14680	COG0795	lipopolysaccharide-transporting ATPase activity
I6L29_14720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L29_14720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L29_14730	COG0004	ammonium transporteR
I6L29_14735	COG0347	Belongs to the P(II) protein family
I6L29_14745	COG0606	chelatase, subunit chli
I6L29_14750	COG0431	NADPH-dependent FMN reductase
I6L29_14755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L29_14760	COG0235	Class ii aldolase
I6L29_14765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L29_14785	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L29_14800	COG0318	PFAM AMP-dependent synthetase and ligase
I6L29_14810	COG0477	Major facilitator Superfamily
I6L29_14815	COG2860	membrane
I6L29_14825	COG1253	flavin adenine dinucleotide binding
I6L29_14835	COG2814	Major facilitator Superfamily
I6L29_14845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L29_14885	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6L29_14900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L29_14930	COG1309	transcriptional regulator
I6L29_14965	COG0758	DNA mediated transformation
I6L29_14975	COG0697	spore germination
I6L29_14980	COG1309	transcriptional regulator
I6L29_14995	COG0386	Belongs to the glutathione peroxidase family
I6L29_15010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6L29_15020	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6L29_15060	COG1121	(ABC) transporter
I6L29_15065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L29_15070	COG1280	lysine exporter protein (LysE YggA)
I6L29_15075	COG2837	iron assimilation
I6L29_15080	COG0281	malic enzyme
I6L29_15125	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L29_15125	COG0519	Catalyzes the synthesis of GMP from XMP
I6L29_15130	COG4399	Belongs to the UPF0754 family
I6L29_15135	COG2259	Doxx family
I6L29_15140	COG0586	Pfam SNARE associated Golgi protein
I6L29_15155	COG1192	Involved in chromosome partitioning
I6L29_15165	COG0271	Belongs to the BolA IbaG family
I6L29_15205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L29_15205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L29_15205	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6L29_15205	COG3321	synthase
I6L29_15210	COG1960	acyl-CoA dehydrogenase activity
I6L29_15215	COG0318	PFAM AMP-dependent synthetase and ligase
I6L29_15220	COG2197	response regulator
I6L29_15230	COG3916	Acyl-homoserine-lactone synthase
I6L29_15235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L29_15245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L29_15250	COG1113	amino acid transport
I6L29_15255	COG0697	spore germination
I6L29_15260	COG0477	Major facilitator Superfamily
I6L29_15265	COG1024	Enoyl-CoA hydratase
I6L29_15270	COG1024	Enoyl-CoA hydratase
I6L29_15275	COG1960	acyl-CoA dehydrogenase activity
I6L29_15280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L29_15300	COG1113	amino acid transport
I6L29_15305	COG1113	amino acid transport
I6L29_15310	COG0251	oxidation-reduction process
I6L29_15350	COG0564	pseudouridine synthase activity
I6L29_15380	COG3328	transposase activity
I6L29_15435	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6L29_15450	COG1802	Transcriptional regulator
I6L29_15460	COG1448	Aminotransferase
I6L29_15465	COG0277	FAD linked oxidase domain protein
I6L29_15475	COG2186	Transcriptional regulator
I6L29_15485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L29_15500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L29_15505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6L29_15540	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6L29_15565	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6L29_15595	COG0728	peptidoglycan biosynthetic process
I6L29_15600	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L29_15655	COG0546	phosphoglycolate phosphatase activity
I6L29_15660	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_15675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L29_15675	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6L29_15680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L29_15685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L29_15690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L29_15695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L29_15700	COG1116	anion transmembrane transporter activity
I6L29_15705	COG1309	transcriptional regulator
I6L29_15710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6L29_15720	COG0196	riboflavin kinase activity
I6L29_15725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6L29_15735	COG1047	Peptidyl-prolyl cis-trans
I6L29_15775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L29_15780	COG0657	acetylesterase activity
I6L29_15830	COG2951	lytic endotransglycosylase activity
I6L29_15835	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6L29_15850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L29_15860	COG0671	phosphoesterase, PA-phosphatase related
I6L29_15865	COG0861	Integral membrane protein TerC family
I6L29_15875	COG0754	glutathionylspermidine amidase activity
I6L29_15885	COG0402	S-adenosylhomocysteine deaminase activity
I6L29_15900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L29_15920	COG0706	membrane insertase activity
I6L29_15945	COG0592	DNA-directed DNA polymerase activity
I6L29_15955	COG0187	DNA topoisomerase II activity
I6L29_15970	COG0488	(ABC) transporter
I6L29_15995	COG0596	Alpha beta hydrolase
I6L29_16000	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6L29_16005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L29_16035	COG0625	glutathione transferase activity
I6L29_16045	COG0733	neurotransmitter:sodium symporter activity
I6L29_16085	COG2233	PERMEase
I6L29_16100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L29_16135	COG2814	Major facilitator Superfamily
I6L29_16140	COG0656	L-ascorbic acid biosynthetic process
I6L29_16145	COG0583	DNA-binding transcription factor activity
I6L29_16160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L29_16165	COG1064	alcohol dehydrogenase
I6L29_16170	COG2818	Glycosylase
I6L29_16185	COG1194	a g-specific adenine glycosylase
I6L29_16200	COG5487	UPF0391 membrane protein
I6L29_16205	COG2983	Belongs to the UPF0260 family
I6L29_16210	COG2133	pyrroloquinoline quinone binding
I6L29_16215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L29_16220	COG2116	formate transmembrane transporter activity
I6L29_16240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L29_16245	COG1335	isochorismatase
I6L29_16250	COG0385	Bile acid
I6L29_16255	COG0534	Mate efflux family protein
I6L29_16260	COG1683	Conserved Protein
I6L29_16275	COG0346	lactoylglutathione lyase activity
I6L29_16280	COG0625	glutathione transferase activity
I6L29_16290	COG1113	amino acid transport
I6L29_16300	COG0523	cobalamin synthesis protein
I6L29_16310	COG2188	Transcriptional regulator
I6L29_16340	COG0010	Belongs to the arginase family
I6L29_16375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6L29_16385	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6L29_16390	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6L29_16490	COG0534	Mate efflux family protein
I6L29_16495	COG0436	Aminotransferase
I6L29_16500	COG2733	membrane
I6L29_16515	COG2918	glutathione biosynthetic process
I6L29_16560	COG3150	esterase
I6L29_16570	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6L29_16580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L29_16590	COG2233	PERMEase
I6L29_16595	COG2351	hydroxyisourate hydrolase activity
I6L29_16630	COG3706	GGDEF domain
I6L29_16645	COG1393	Belongs to the ArsC family
I6L29_16650	COG0708	Exodeoxyribonuclease III
I6L29_16670	COG0189	ligase activity
I6L29_16690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6L29_16700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6L29_16715	COG4942	peptidase
I6L29_16725	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L29_16735	COG2119	membrane
I6L29_16740	COG4774	siderophore transport
I6L29_16745	COG0426	domain, Protein
I6L29_16745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L29_16765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6L29_16785	COG1902	pentaerythritol trinitrate reductase activity
I6L29_16790	COG1519	Transferase
I6L29_16795	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L29_16800	COG0668	transmembrane transport
I6L29_16810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L29_16815	COG1335	isochorismatase
I6L29_16820	COG1522	sequence-specific DNA binding
I6L29_16845	COG2205	protein histidine kinase activity
I6L29_16845	COG2198	Histidine kinase
I6L29_16845	COG0784	Response regulator, receiver
I6L29_16850	COG3162	membrane
I6L29_16855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L29_16865	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L29_16890	COG1309	transcriptional regulator
I6L29_16910	COG0300	oxidoreductase activity
I6L29_16915	COG0789	Transcriptional regulator
I6L29_16920	COG0351	phosphomethylpyrimidine kinase
I6L29_16920	COG0352	thiamine-phosphate diphosphorylase activity
I6L29_16920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6L29_16930	COG2814	Major facilitator Superfamily
I6L29_16945	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6L29_16955	COG1113	amino acid transport
I6L29_16965	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L29_16970	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_16980	COG1335	isochorismatase
I6L29_17020	COG2814	Major facilitator Superfamily
I6L29_17025	COG0583	DNA-binding transcription factor activity
I6L29_17045	COG0667	Aldo Keto reductase
I6L29_17060	COG1309	transcriptional regulator
I6L29_17080	COG1733	regulation of RNA biosynthetic process
I6L29_17085	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L29_17170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L29_17185	COG2329	Antibiotic biosynthesis monooxygenase
I6L29_17190	COG0697	spore germination
I6L29_17200	COG1132	(ABC) transporter
I6L29_17210	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6L29_17220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L29_17250	COG0427	acetyl-CoA hydrolase
I6L29_17275	COG0659	secondary active sulfate transmembrane transporter activity
I6L29_17280	COG4221	oxidoreductase activity
I6L29_17285	COG2873	o-acetylhomoserine
I6L29_17290	COG0488	(ABC) transporter
I6L29_17370	COG0833	amino acid
I6L29_17415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L29_17420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L29_17435	COG2226	methyltransferase
I6L29_17485	COG0070	glutamate synthase
I6L29_17485	COG0069	glutamate synthase activity
I6L29_17485	COG0067	glutamate synthase
I6L29_17490	COG0493	'glutamate synthase
I6L29_17500	COG1704	LemA family
I6L29_17505	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L29_17515	COG4969	Belongs to the N-Me-Phe pilin family
I6L29_17525	COG3328	transposase activity
I6L29_17535	COG3307	-O-antigen
I6L29_17560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L29_17575	COG0194	GDP metabolic process
I6L29_17625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6L29_17635	COG0335	large ribosomal subunit rRNA binding
I6L29_17645	COG5380	lipid catabolic process
I6L29_17650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6L29_17665	COG5006	permease, DMT superfamily
I6L29_17670	COG5006	permease, DMT superfamily
I6L29_17675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L29_17680	COG0277	FAD linked oxidase domain protein
I6L29_17690	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6L29_17695	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L29_17710	COG1289	transmembrane transporter activity
I6L29_17720	COG0628	permease
I6L29_17725	COG1192	Involved in chromosome partitioning
I6L29_17755	COG0833	amino acid
I6L29_17760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L29_17765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L29_17775	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_17815	COG0583	DNA-binding transcription factor activity
I6L29_17845	COG0752	glycyl-tRNA synthetase alpha subunit
I6L29_17865	COG0617	tRNA 3'-terminal CCA addition
I6L29_17865	COG0517	IMP dehydrogenase activity
I6L29_17865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6L29_17870	COG1983	PspC domain protein
I6L29_17880	COG1960	acyl-CoA dehydrogenase activity
I6L29_17895	COG0408	coproporphyrinogen oxidase activity
I6L29_17915	COG0513	Belongs to the DEAD box helicase family
I6L29_17925	COG1127	ABC transporter
I6L29_17930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6L29_17940	COG2854	intermembrane phospholipid transfer
I6L29_17950	COG0598	Magnesium transport protein CorA
I6L29_17960	COG0494	nUDIX hydrolase
I6L29_17965	COG1040	competence protein
I6L29_17970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L29_17990	COG1946	Acyl-CoA thioesterase
I6L29_17995	COG1301	dicarboxylic acid transport
I6L29_18010	COG1959	2 iron, 2 sulfur cluster binding
I6L29_18015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L29_18015	COG1017	nitric oxide dioxygenase activity
I6L29_18025	COG0433	COG0433 Predicted ATPase
I6L29_18030	COG0626	cystathionine gamma-synthase activity
I6L29_18045	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6L29_18050	COG0088	Forms part of the polypeptide exit tunnel
I6L29_18185	COG1960	acyl-CoA dehydrogenase activity
I6L29_18190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6L29_18220	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6L29_18225	COG0339	signal peptide processing
I6L29_18230	COG0557	exoribonuclease II activity
I6L29_18260	COG3328	transposase activity
I6L29_18285	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6L29_18300	COG0477	Major facilitator Superfamily
I6L29_18305	COG0697	spore germination
I6L29_18315	COG0604	alcohol dehydrogenase
I6L29_18315	COG3321	synthase
I6L29_18320	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6L29_18325	COG0583	DNA-binding transcription factor activity
I6L29_18330	COG3328	transposase activity
I6L29_18345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L29_18360	COG4772	TonB-dependent receptor
I6L29_18375	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6L29_18415	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
I6L29_18495	COG3586	endonuclease activity
I6L29_18530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L29_18610	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L29_18630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L29_18690	COG4372	Transposase
I6L29_18720	COG0358	DNA primase activity
I6L29_18740	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6L29_18800	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6L29_18820	COG3328	transposase activity
I6L29_18830	COG0582	viral genome integration into host DNA
I6L29_18845	COG2130	NADP-dependent
I6L29_18850	COG1309	transcriptional regulator
I6L29_18860	COG1902	pentaerythritol trinitrate reductase activity
I6L29_18870	COG1979	alcohol dehydrogenase
I6L29_18885	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6L29_18950	COG4683	PFAM Phage derived protein Gp49-like (DUF891)