locus-tag	class	description
EPY81_00015	COG2321	neutral zinc metallopeptidase
EPY81_00020	COG2354	Protein conserved in bacteria
EPY81_00040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPY81_00065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EPY81_00070	COG1053	succinate dehydrogenase
EPY81_00075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EPY81_00080	COG2009	succinate dehydrogenase
EPY81_00120	COG2921	Belongs to the UPF0250 family
EPY81_00125	COG0321	lipoyl(octanoyl) transferase activity
EPY81_00140	COG0531	amino acid
EPY81_00175	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EPY81_00180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EPY81_00180	COG1648	precorrin-2 dehydrogenase activity
EPY81_00195	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EPY81_00220	COG0671	phosphoesterase, PA-phosphatase related
EPY81_00225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPY81_00235	COG1538	Outer membrane efflux protein
EPY81_00240	COG0393	Putative heavy-metal-binding
EPY81_00245	COG0393	Putative heavy-metal-binding
EPY81_00255	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_00265	COG0525	valine-tRNA ligase activity
EPY81_00285	COG0583	DNA-binding transcription factor activity
EPY81_00290	COG0004	ammonium transporteR
EPY81_00305	COG0642	Histidine kinase
EPY81_00310	COG0745	RESPONSE REGULATOR receiver
EPY81_00315	COG2194	sulfuric ester hydrolase activity
EPY81_00340	COG1752	Esterase of the alpha-beta hydrolase superfamily
EPY81_00355	COG2315	Protein conserved in bacteria
EPY81_00360	COG0142	geranyltranstransferase activity
EPY81_00365	COG2828	Protein conserved in bacteria
EPY81_00370	COG1113	amino acid transport
EPY81_00380	COG3046	protein related to deoxyribodipyrimidine photolyase
EPY81_00400	COG0582	viral genome integration into host DNA
EPY81_00435	COG0305	Participates in initiation and elongation during chromosome replication
EPY81_00515	COG2207	Transcriptional regulator
EPY81_00540	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPY81_00560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPY81_00570	COG1530	ribonuclease E activity
EPY81_00575	COG0424	maF-like protein
EPY81_00580	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EPY81_00585	COG1792	Involved in formation and maintenance of cell shape
EPY81_00590	COG1077	Cell shape determining protein MreB Mrl
EPY81_00595	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EPY81_00605	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EPY81_00630	COG3590	peptidase
EPY81_00635	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
EPY81_00640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EPY81_00645	COG1752	Esterase of the alpha-beta hydrolase superfamily
EPY81_00650	COG1115	amino acid carrier protein
EPY81_00675	COG2814	Major facilitator Superfamily
EPY81_00680	COG1289	transmembrane transporter activity
EPY81_00690	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPY81_00730	COG1376	ErfK ybiS ycfS ynhG family protein
EPY81_00735	COG2832	Protein of unknown function (DUF454)
EPY81_00745	COG5510	response to toxic substance
EPY81_00765	COG0840	transmembrane signaling receptor activity
EPY81_00805	COG3422	double-strand break repair
EPY81_00810	COG2824	Alkylphosphonate utilization operon protein PhnA
EPY81_00820	COG0596	Alpha beta hydrolase
EPY81_00830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPY81_00835	COG1335	isochorismatase
EPY81_00840	COG0251	oxidation-reduction process
EPY81_00845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPY81_00850	COG2233	PERMEase
EPY81_00870	COG0354	folic acid binding
EPY81_00875	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPY81_00890	COG1902	pentaerythritol trinitrate reductase activity
EPY81_00895	COG4772	TonB-dependent receptor
EPY81_00900	COG2094	Belongs to the DNA glycosylase MPG family
EPY81_00930	COG2233	PERMEase
EPY81_00940	COG0833	amino acid
EPY81_00945	COG1690	Belongs to the RtcB family
EPY81_00950	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EPY81_00950	COG2885	chlorophyll binding
EPY81_00960	COG0183	Belongs to the thiolase family
EPY81_00980	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPY81_01000	COG2207	Transcriptional regulator
EPY81_01005	COG0183	Belongs to the thiolase family
EPY81_01025	COG2153	protein acetylation
EPY81_01035	COG1272	protein, Hemolysin III
EPY81_01040	COG0477	Major facilitator Superfamily
EPY81_01055	COG0450	alkyl hydroperoxide reductase
EPY81_01075	COG0285	dihydrofolate synthase activity
EPY81_01120	COG4206	TonB-dependent receptor
EPY81_01125	COG2096	Adenosyltransferase
EPY81_01145	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EPY81_01155	COG0745	RESPONSE REGULATOR receiver
EPY81_01160	COG2205	protein histidine kinase activity
EPY81_01170	COG1960	acyl-CoA dehydrogenase activity
EPY81_01175	COG1960	acyl-CoA dehydrogenase activity
EPY81_01180	COG0583	DNA-binding transcription factor activity
EPY81_01185	COG0625	glutathione transferase activity
EPY81_01235	COG1216	Glycosyl transferase, family 2
EPY81_01250	COG0726	polysaccharide deacetylase
EPY81_01265	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EPY81_01270	COG0784	Response regulator, receiver
EPY81_01270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPY81_01270	COG2198	Histidine kinase
EPY81_01270	COG2205	protein histidine kinase activity
EPY81_01305	COG1862	Preprotein translocase
EPY81_01315	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPY81_01320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EPY81_01330	COG3781	membrane
EPY81_01345	COG2350	Protein conserved in bacteria
EPY81_01380	COG1607	acyl-coa hydrolase
EPY81_01450	COG2199	diguanylate cyclase activity
EPY81_01455	COG2885	chlorophyll binding
EPY81_01455	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EPY81_01460	COG1408	metallophosphoesterase
EPY81_01465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPY81_01475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EPY81_01495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EPY81_01500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EPY81_01505	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EPY81_01510	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EPY81_01515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EPY81_01520	COG0625	glutathione transferase activity
EPY81_01525	COG2969	positive regulation of protein catabolic process
EPY81_01565	COG1960	acyl-CoA dehydrogenase activity
EPY81_01570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EPY81_01585	COG1309	transcriptional regulator
EPY81_01590	COG1960	acyl-CoA dehydrogenase activity
EPY81_01635	COG1183	phosphatidylcholine synthase activity
EPY81_01640	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EPY81_01670	COG1196	nuclear chromosome segregation
EPY81_01670	COG0741	lytic transglycosylase activity
EPY81_01670	COG0739	heme binding
EPY81_01680	COG1702	phosphate starvation-inducible protein PhoH
EPY81_01715	COG1295	ribonuclease BN
EPY81_01720	COG0179	Fumarylacetoacetate (FAA) hydrolase
EPY81_01770	COG0557	exoribonuclease II activity
EPY81_01775	COG0339	signal peptide processing
EPY81_01780	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
EPY81_01810	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EPY81_01815	COG1960	acyl-CoA dehydrogenase activity
EPY81_01950	COG0088	Forms part of the polypeptide exit tunnel
EPY81_01955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EPY81_01970	COG0626	cystathionine gamma-synthase activity
EPY81_01975	COG0433	COG0433 Predicted ATPase
EPY81_01985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPY81_01985	COG1017	nitric oxide dioxygenase activity
EPY81_01990	COG1959	2 iron, 2 sulfur cluster binding
EPY81_02005	COG1301	dicarboxylic acid transport
EPY81_02010	COG1946	Acyl-CoA thioesterase
EPY81_02015	COG2937	Belongs to the GPAT DAPAT family
EPY81_02030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EPY81_02035	COG1040	competence protein
EPY81_02040	COG0494	nUDIX hydrolase
EPY81_02050	COG0598	Magnesium transport protein CorA
EPY81_02060	COG2854	intermembrane phospholipid transfer
EPY81_02070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EPY81_02075	COG1127	ABC transporter
EPY81_02085	COG0513	Belongs to the DEAD box helicase family
EPY81_02105	COG0408	coproporphyrinogen oxidase activity
EPY81_02120	COG1960	acyl-CoA dehydrogenase activity
EPY81_02130	COG1983	PspC domain protein
EPY81_02135	COG0517	IMP dehydrogenase activity
EPY81_02160	COG0752	glycyl-tRNA synthetase alpha subunit
EPY81_02185	COG5002	protein histidine kinase activity
EPY81_02200	COG0583	DNA-binding transcription factor activity
EPY81_02240	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_02250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPY81_02255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EPY81_02260	COG0833	amino acid
EPY81_02290	COG1192	Involved in chromosome partitioning
EPY81_02295	COG0628	permease
EPY81_02305	COG1289	transmembrane transporter activity
EPY81_02320	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPY81_02325	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EPY81_02335	COG0277	FAD linked oxidase domain protein
EPY81_02340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPY81_02345	COG5006	permease, DMT superfamily
EPY81_02350	COG5006	permease, DMT superfamily
EPY81_02365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EPY81_02370	COG5380	lipid catabolic process
EPY81_02380	COG0335	large ribosomal subunit rRNA binding
EPY81_02390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EPY81_02440	COG0194	GDP metabolic process
EPY81_02455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPY81_02480	COG3307	-O-antigen
EPY81_02490	COG4969	Belongs to the N-Me-Phe pilin family
EPY81_02500	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EPY81_02505	COG1704	LemA family
EPY81_02515	COG0493	'glutamate synthase
EPY81_02520	COG0070	glutamate synthase
EPY81_02520	COG0069	glutamate synthase activity
EPY81_02520	COG0067	glutamate synthase
EPY81_02570	COG2226	methyltransferase
EPY81_02585	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EPY81_02590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EPY81_02635	COG0833	amino acid
EPY81_02655	COG0582	viral genome integration into host DNA
EPY81_02815	COG0488	(ABC) transporter
EPY81_02820	COG2873	o-acetylhomoserine
EPY81_02825	COG4221	oxidoreductase activity
EPY81_02830	COG0659	secondary active sulfate transmembrane transporter activity
EPY81_02840	COG0745	RESPONSE REGULATOR receiver
EPY81_02845	COG2205	protein histidine kinase activity
EPY81_02855	COG0427	acetyl-CoA hydrolase
EPY81_02885	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EPY81_02910	COG0697	spore germination
EPY81_02925	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EPY81_02985	COG2207	Transcriptional regulator
EPY81_02990	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EPY81_03000	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPY81_03010	COG1733	regulation of RNA biosynthetic process
EPY81_03055	COG0667	Aldo Keto reductase
EPY81_03075	COG0583	DNA-binding transcription factor activity
EPY81_03080	COG2814	Major facilitator Superfamily
EPY81_03170	COG1335	isochorismatase
EPY81_03180	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_03185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPY81_03195	COG1113	amino acid transport
EPY81_03205	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EPY81_03220	COG2814	Major facilitator Superfamily
EPY81_03230	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EPY81_03230	COG0351	phosphomethylpyrimidine kinase
EPY81_03230	COG0352	thiamine-phosphate diphosphorylase activity
EPY81_03235	COG0789	Transcriptional regulator
EPY81_03240	COG0300	oxidoreductase activity
EPY81_03260	COG1309	transcriptional regulator
EPY81_03275	COG3706	GGDEF domain
EPY81_03285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPY81_03295	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPY81_03300	COG3162	membrane
EPY81_03305	COG2205	protein histidine kinase activity
EPY81_03305	COG2198	Histidine kinase
EPY81_03305	COG0784	Response regulator, receiver
EPY81_03325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPY81_03330	COG1522	sequence-specific DNA binding
EPY81_03335	COG1335	isochorismatase
EPY81_03340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPY81_03350	COG0668	transmembrane transport
EPY81_03355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EPY81_03360	COG1519	Transferase
EPY81_03365	COG1902	pentaerythritol trinitrate reductase activity
EPY81_03385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EPY81_03405	COG0426	domain, Protein
EPY81_03405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPY81_03410	COG4774	siderophore transport
EPY81_03415	COG2119	membrane
EPY81_03425	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPY81_03435	COG4942	peptidase
EPY81_03450	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EPY81_03460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EPY81_03480	COG0189	ligase activity
EPY81_03500	COG0708	Exodeoxyribonuclease III
EPY81_03505	COG1393	Belongs to the ArsC family
EPY81_03520	COG3706	GGDEF domain
EPY81_03555	COG2351	hydroxyisourate hydrolase activity
EPY81_03560	COG2233	PERMEase
EPY81_03570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPY81_03580	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
EPY81_03590	COG3150	esterase
EPY81_03625	COG3501	Rhs element vgr protein
EPY81_03635	COG2918	glutathione biosynthetic process
EPY81_03650	COG2733	membrane
EPY81_03655	COG0436	Aminotransferase
EPY81_03660	COG0534	Mate efflux family protein
EPY81_03765	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EPY81_03770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EPY81_03780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EPY81_03820	COG0010	Belongs to the arginase family
EPY81_03850	COG2188	Transcriptional regulator
EPY81_03860	COG0523	cobalamin synthesis protein
EPY81_03870	COG1113	amino acid transport
EPY81_03880	COG0625	glutathione transferase activity
EPY81_03885	COG0346	lactoylglutathione lyase activity
EPY81_03900	COG1683	Conserved Protein
EPY81_03905	COG0534	Mate efflux family protein
EPY81_03910	COG0385	Bile acid
EPY81_03915	COG1335	isochorismatase
EPY81_03920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPY81_03940	COG2116	formate transmembrane transporter activity
EPY81_03945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EPY81_03950	COG2133	pyrroloquinoline quinone binding
EPY81_03955	COG2983	Belongs to the UPF0260 family
EPY81_03960	COG5487	UPF0391 membrane protein
EPY81_03975	COG1194	a g-specific adenine glycosylase
EPY81_03990	COG2818	Glycosylase
EPY81_03995	COG1064	alcohol dehydrogenase
EPY81_04000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPY81_04015	COG0583	DNA-binding transcription factor activity
EPY81_04020	COG0656	L-ascorbic acid biosynthetic process
EPY81_04025	COG2814	Major facilitator Superfamily
EPY81_04060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPY81_04075	COG2233	PERMEase
EPY81_04115	COG0733	neurotransmitter:sodium symporter activity
EPY81_04125	COG0625	glutathione transferase activity
EPY81_04160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPY81_04165	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EPY81_04170	COG0596	Alpha beta hydrolase
EPY81_04195	COG0488	(ABC) transporter
EPY81_04210	COG0187	DNA topoisomerase II activity
EPY81_04220	COG0592	DNA-directed DNA polymerase activity
EPY81_04245	COG0706	membrane insertase activity
EPY81_04260	COG1230	cation diffusion facilitator family transporter
EPY81_04265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPY81_04280	COG0402	S-adenosylhomocysteine deaminase activity
EPY81_04290	COG0754	glutathionylspermidine amidase activity
EPY81_04300	COG0861	Integral membrane protein TerC family
EPY81_04305	COG0671	phosphoesterase, PA-phosphatase related
EPY81_04315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPY81_04330	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EPY81_04335	COG2951	lytic endotransglycosylase activity
EPY81_04390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPY81_04430	COG1047	Peptidyl-prolyl cis-trans
EPY81_04440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EPY81_04445	COG0196	riboflavin kinase activity
EPY81_04455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EPY81_04460	COG1309	transcriptional regulator
EPY81_04465	COG1116	anion transmembrane transporter activity
EPY81_04470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPY81_04475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPY81_04480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPY81_04485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPY81_04490	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPY81_04490	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EPY81_04505	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_04510	COG0546	phosphoglycolate phosphatase activity
EPY81_04565	COG3023	N-Acetylmuramoyl-L-alanine amidase
EPY81_04570	COG0728	peptidoglycan biosynthetic process
EPY81_04600	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EPY81_04620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EPY81_04630	COG1091	dTDP-4-dehydrorhamnose reductase activity
EPY81_04645	COG1215	transferase activity, transferring glycosyl groups
EPY81_04665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPY81_04670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EPY81_04685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPY81_04695	COG2186	Transcriptional regulator
EPY81_04705	COG0277	FAD linked oxidase domain protein
EPY81_04710	COG1448	Aminotransferase
EPY81_04720	COG1802	Transcriptional regulator
EPY81_04735	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EPY81_04755	COG1051	belongs to the nudix hydrolase family
EPY81_04830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPY81_04855	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EPY81_04875	COG0564	pseudouridine synthase activity
EPY81_04915	COG0251	oxidation-reduction process
EPY81_04920	COG1113	amino acid transport
EPY81_04925	COG1113	amino acid transport
EPY81_04945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPY81_04950	COG1960	acyl-CoA dehydrogenase activity
EPY81_04955	COG1024	Enoyl-CoA hydratase
EPY81_04960	COG1024	Enoyl-CoA hydratase
EPY81_04965	COG0477	Major facilitator Superfamily
EPY81_04970	COG0697	spore germination
EPY81_04975	COG1113	amino acid transport
EPY81_04980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPY81_04990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPY81_04995	COG3916	Acyl-homoserine-lactone synthase
EPY81_05005	COG2197	response regulator
EPY81_05010	COG0318	PFAM AMP-dependent synthetase and ligase
EPY81_05015	COG1960	acyl-CoA dehydrogenase activity
EPY81_05020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPY81_05020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPY81_05020	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
EPY81_05020	COG3321	synthase
EPY81_05060	COG0271	Belongs to the BolA IbaG family
EPY81_05070	COG1192	Involved in chromosome partitioning
EPY81_05085	COG0586	Pfam SNARE associated Golgi protein
EPY81_05090	COG2259	Doxx family
EPY81_05095	COG4399	Belongs to the UPF0754 family
EPY81_05100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EPY81_05100	COG0519	Catalyzes the synthesis of GMP from XMP
EPY81_05145	COG0281	malic enzyme
EPY81_05150	COG2837	iron assimilation
EPY81_05155	COG1280	lysine exporter protein (LysE YggA)
EPY81_05160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPY81_05165	COG1121	(ABC) transporter
EPY81_05205	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EPY81_05215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EPY81_05230	COG0386	Belongs to the glutathione peroxidase family
EPY81_05245	COG1309	transcriptional regulator
EPY81_05250	COG0697	spore germination
EPY81_05260	COG0758	DNA mediated transformation
EPY81_05295	COG1309	transcriptional regulator
EPY81_05325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPY81_05340	COG0655	NAD(P)H dehydrogenase (quinone) activity
EPY81_05380	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EPY81_05390	COG2814	Major facilitator Superfamily
EPY81_05400	COG1253	flavin adenine dinucleotide binding
EPY81_05410	COG2860	membrane
EPY81_05415	COG0477	Major facilitator Superfamily
EPY81_05425	COG0318	PFAM AMP-dependent synthetase and ligase
EPY81_05440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EPY81_05460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPY81_05465	COG0235	Class ii aldolase
EPY81_05470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPY81_05475	COG0431	NADPH-dependent FMN reductase
EPY81_05480	COG0606	chelatase, subunit chli
EPY81_05490	COG0347	Belongs to the P(II) protein family
EPY81_05495	COG0004	ammonium transporteR
EPY81_05505	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPY81_05505	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPY81_05545	COG0795	lipopolysaccharide-transporting ATPase activity
EPY81_05550	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EPY81_05555	COG0793	Belongs to the peptidase S41A family
EPY81_05570	COG2197	response regulator
EPY81_05580	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EPY81_05590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPY81_05595	COG4974	Belongs to the 'phage' integrase family
EPY81_05620	COG0772	Belongs to the SEDS family
EPY81_05625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPY81_05630	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EPY81_05635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EPY81_05640	COG0494	nUDIX hydrolase
EPY81_05660	COG0697	spore germination
EPY81_05670	COG1538	Outer membrane efflux protein
EPY81_05690	COG3275	phosphorelay sensor kinase activity
EPY81_05700	COG0181	hydroxymethylbilane synthase activity
EPY81_05745	COG1716	ATPase activity
EPY81_05750	COG0546	phosphoglycolate phosphatase activity
EPY81_05780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPY81_05850	COG2056	Na+-H+ antiporter family
EPY81_05865	COG0326	Molecular chaperone. Has ATPase activity
EPY81_05880	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EPY81_05950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EPY81_05955	COG2169	Transcriptional regulator
EPY81_05955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EPY81_05990	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EPY81_06000	COG0497	DNA recombination
EPY81_06015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPY81_06025	COG0237	dephospho-CoA kinase activity
EPY81_06075	COG0195	Participates in both transcription termination and antitermination
EPY81_06085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EPY81_06095	COG2212	antiporter activity
EPY81_06105	COG0651	ATP synthesis coupled electron transport
EPY81_06110	COG1006	Multisubunit Na H antiporter MnhC subunit
EPY81_06115	COG2111	Na H antiporter
EPY81_06115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EPY81_06130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EPY81_06140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPY81_06155	COG2226	methyltransferase
EPY81_06175	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EPY81_06180	COG1074	ATP-dependent DNA helicase activity
EPY81_06185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPY81_06200	COG1185	polyribonucleotide nucleotidyltransferase activity
EPY81_06205	COG0598	Magnesium transport protein CorA
EPY81_06210	COG0789	Transcriptional regulator
EPY81_06215	COG0484	heat shock protein binding
EPY81_06225	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EPY81_06235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EPY81_06255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPY81_06265	COG4535	Mg2 and Co2 transporter CorC
EPY81_06280	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
EPY81_06280	COG0644	oxidoreductase
EPY81_06290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EPY81_06305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPY81_06310	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EPY81_06320	COG0493	'glutamate synthase
EPY81_06345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EPY81_06360	COG0534	Mate efflux family protein
EPY81_06370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPY81_06375	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_06380	COG0583	DNA-binding transcription factor activity
EPY81_06395	COG0318	PFAM AMP-dependent synthetase and ligase
EPY81_06400	COG1530	ribonuclease E activity
EPY81_06415	COG0546	phosphoglycolate phosphatase activity
EPY81_06420	COG2378	regulation of single-species biofilm formation
EPY81_06425	COG0625	glutathione transferase activity
EPY81_06435	COG0583	DNA-binding transcription factor activity
EPY81_06475	COG0583	DNA-binding transcription factor activity
EPY81_06500	COG0473	3-isopropylmalate dehydrogenase activity
EPY81_06555	COG1301	dicarboxylic acid transport
EPY81_06565	COG1560	Kdo2-lipid A biosynthetic process
EPY81_06580	COG2900	Belongs to the SlyX family
EPY81_06590	COG1733	regulation of RNA biosynthetic process
EPY81_06615	COG0210	DNA helicase
EPY81_06620	COG0724	RNA recognition motif
EPY81_06640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPY81_06640	COG4651	solute:proton antiporter activity
EPY81_06665	COG0788	formyltetrahydrofolate deformylase activity
EPY81_06765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPY81_06765	COG2813	Specifically methylates the guanine in position
EPY81_06775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EPY81_06785	COG4774	siderophore transport
EPY81_06795	COG0740	serine-type endopeptidase activity
EPY81_06815	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EPY81_06815	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EPY81_06820	COG0857	belongs to the CobB CobQ family
EPY81_06820	COG0280	phosphate acetyltransferase
EPY81_06825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EPY81_06840	COG0800	Aldolase
EPY81_06850	COG3265	gluconokinase activity
EPY81_06855	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_06865	COG2267	carboxylic ester hydrolase activity
EPY81_06880	COG0793	Belongs to the peptidase S41A family
EPY81_06915	COG1426	Protein conserved in bacteria
EPY81_06935	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPY81_06955	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPY81_06965	COG1162	GTPase activity
EPY81_06970	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EPY81_07000	COG0577	efflux transmembrane transporter activity
EPY81_07000	COG1136	(ABC) transporter
EPY81_07005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPY81_07025	COG0028	Belongs to the TPP enzyme family
EPY81_07030	COG0440	acetolactate synthase activity
EPY81_07035	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EPY81_07055	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EPY81_07070	COG0084	hydrolase, TatD family'
EPY81_07080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EPY81_07090	COG0583	DNA-binding transcription factor activity
EPY81_07105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPY81_07185	COG2217	Heavy metal translocating P-type atpase
EPY81_07190	COG2205	protein histidine kinase activity
EPY81_07205	COG2132	Multicopper oxidase
EPY81_07230	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPY81_07255	COG0789	Transcriptional regulator
EPY81_07290	COG2814	Major facilitator Superfamily
EPY81_07300	COG0697	spore germination
EPY81_07335	COG3622	Belongs to the hyi family
EPY81_07340	COG2084	Dehydrogenase
EPY81_07345	COG1024	Enoyl-CoA hydratase
EPY81_07350	COG2205	protein histidine kinase activity
EPY81_07350	COG0784	Response regulator, receiver
EPY81_07350	COG5002	protein histidine kinase activity
EPY81_07355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPY81_07370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPY81_07375	COG4221	oxidoreductase activity
EPY81_07380	COG3956	TIGRFAM MazG family protein
EPY81_07385	COG1555	photosystem II stabilization
EPY81_07390	COG0617	tRNA 3'-terminal CCA addition
EPY81_07395	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPY81_07415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPY81_07420	COG3028	Belongs to the UPF0307 family
EPY81_07425	COG0318	PFAM AMP-dependent synthetase and ligase
EPY81_07445	COG0625	glutathione transferase activity
EPY81_07450	COG1238	metal cluster binding
EPY81_07465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EPY81_07490	COG0072	phenylalanine-tRNA ligase activity
EPY81_07520	COG0248	Ppx GppA phosphatase
EPY81_07530	COG0037	tRNA processing
EPY81_07570	COG1764	response to oxidative stress
EPY81_07575	COG1846	Transcriptional regulator
EPY81_07585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPY81_07645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EPY81_07650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EPY81_07655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EPY81_07715	COG1214	PFAM Peptidase M22, glycoprotease
EPY81_07730	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EPY81_07740	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EPY81_07745	COG0561	phosphatase activity
EPY81_07755	COG2132	Multicopper oxidase
EPY81_07775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EPY81_07780	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EPY81_07785	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EPY81_07815	COG1063	alcohol dehydrogenase
EPY81_07820	COG0583	DNA-binding transcription factor activity
EPY81_07825	COG1960	acyl-CoA dehydrogenase activity
EPY81_07830	COG2814	Major facilitator Superfamily
EPY81_07835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EPY81_07845	COG1309	transcriptional regulator
EPY81_07860	COG1053	succinate dehydrogenase
EPY81_07865	COG0583	DNA-binding transcription factor activity
EPY81_07900	COG0583	DNA-binding transcription factor activity
EPY81_07935	COG0583	DNA-binding transcription factor activity
EPY81_07950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPY81_08015	COG0438	transferase activity, transferring glycosyl groups
EPY81_08020	COG0110	maltose O-acetyltransferase activity
EPY81_08060	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPY81_08075	COG0745	RESPONSE REGULATOR receiver
EPY81_08080	COG2205	protein histidine kinase activity
EPY81_08090	COG2199	diguanylate cyclase activity
EPY81_08115	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EPY81_08145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EPY81_08150	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPY81_08170	COG0583	DNA-binding transcription factor activity
EPY81_08190	COG0668	transmembrane transport
EPY81_08200	COG2081	HI0933 family
EPY81_08205	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EPY81_08240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPY81_08240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPY81_08250	COG0489	protein tyrosine kinase activity
EPY81_08305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPY81_08315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EPY81_08330	COG0730	response to heat
EPY81_08340	COG1196	nuclear chromosome segregation
EPY81_08360	COG2223	nitrite transmembrane transporter activity
EPY81_08365	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EPY81_08375	COG2226	methyltransferase
EPY81_08375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPY81_08375	COG0596	Alpha beta hydrolase
EPY81_08390	COG4106	trans-aconitate 2-methyltransferase activity
EPY81_08405	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EPY81_08410	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EPY81_08415	COG0009	L-threonylcarbamoyladenylate synthase
EPY81_08420	COG3101	peptidyl-lysine hydroxylation
EPY81_08425	COG1399	metal-binding, possibly nucleic acid-binding protein
EPY81_08450	COG1652	LysM domain
EPY81_08455	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EPY81_08455	COG0352	thiamine-phosphate diphosphorylase activity
EPY81_08455	COG0351	phosphomethylpyrimidine kinase
EPY81_08465	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPY81_08495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EPY81_08525	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EPY81_08540	COG0358	DNA primase activity
EPY81_08575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPY81_08595	COG0583	DNA-binding transcription factor activity
EPY81_08600	COG0473	3-isopropylmalate dehydrogenase activity
EPY81_08615	COG4638	Rieske (2fe-2S)
EPY81_08620	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_08640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPY81_08640	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EPY81_08665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EPY81_08675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPY81_08680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPY81_08695	COG0456	acetyltransferase
EPY81_08705	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EPY81_08710	COG0492	ferredoxin-NADP+ reductase activity
EPY81_08715	COG1674	ftsk spoiiie
EPY81_08720	COG1280	lysine exporter protein (LysE YggA)
EPY81_08735	COG2894	cell division
EPY81_08750	COG0204	Acyl-transferase
EPY81_08755	COG2885	chlorophyll binding
EPY81_08760	COG0210	DNA helicase
EPY81_08770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPY81_08785	COG0121	glutamine amidotransferase
EPY81_08805	COG2914	Belongs to the UPF0125 (RnfH) family
EPY81_08810	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPY81_08815	COG0735	belongs to the Fur family
EPY81_08840	COG0420	3'-5' exonuclease activity
EPY81_08860	COG1090	epimerase
EPY81_08875	COG2050	protein possibly involved in aromatic compounds catabolism
EPY81_08885	COG2814	Major facilitator Superfamily
EPY81_08890	COG0405	Gamma-glutamyltransferase
EPY81_08900	COG0582	viral genome integration into host DNA
EPY81_08945	COG0629	single-stranded DNA binding
EPY81_08970	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EPY81_08985	COG1401	restriction endodeoxyribonuclease activity
EPY81_09055	COG0477	Major facilitator Superfamily
EPY81_09060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPY81_09110	COG0531	amino acid
EPY81_09115	COG2040	homocysteine
EPY81_09140	COG1309	transcriptional regulator
EPY81_09145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPY81_09150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPY81_09160	COG1607	acyl-coa hydrolase
EPY81_09170	COG0523	cobalamin synthesis protein
EPY81_09180	COG4681	YaeQ
EPY81_09190	COG0726	polysaccharide deacetylase
EPY81_09190	COG1649	PFAM Uncharacterised BCR, COG1649
EPY81_09195	COG1215	transferase activity, transferring glycosyl groups
EPY81_09205	COG1024	Enoyl-CoA hydratase
EPY81_09220	COG1414	Transcriptional regulator
EPY81_09240	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_09250	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPY81_09255	COG2271	Major facilitator Superfamily
EPY81_09265	COG2267	carboxylic ester hydrolase activity
EPY81_09270	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_09285	COG0028	Belongs to the TPP enzyme family
EPY81_09295	COG0477	Major facilitator Superfamily
EPY81_09300	COG0242	peptide deformylase activity
EPY81_09305	COG2066	Belongs to the glutaminase family
EPY81_09310	COG0662	Cupin 2, conserved barrel domain protein
EPY81_09310	COG2207	Transcriptional regulator
EPY81_09315	COG2223	nitrite transmembrane transporter activity
EPY81_09335	COG0583	DNA-binding transcription factor activity
EPY81_09340	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_09345	COG2271	Major facilitator Superfamily
EPY81_09350	COG3959	Transketolase, thiamine diphosphate binding domain
EPY81_09355	COG3958	Transketolase
EPY81_09370	COG0306	phosphate transporter
EPY81_09390	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EPY81_09435	COG4181	ATPase activity
EPY81_09440	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EPY81_09470	COG0583	DNA-binding transcription factor activity
EPY81_09475	COG2267	carboxylic ester hydrolase activity
EPY81_09480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPY81_09485	COG1773	rubredoxin
EPY81_09535	COG2851	Citrate transporter
EPY81_09540	COG1253	flavin adenine dinucleotide binding
EPY81_09555	COG3015	lipoprotein NlpE involved in copper resistance
EPY81_09580	COG0804	urea catabolic process
EPY81_09590	COG0830	nickel cation binding
EPY81_09605	COG0742	ribosomal rna small subunit methyltransferase
EPY81_09610	COG0768	penicillin binding
EPY81_09635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPY81_09640	COG2878	Part of a membrane complex involved in electron transport
EPY81_09645	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EPY81_09655	COG3384	dioxygenase
EPY81_09670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EPY81_09710	COG0006	proline dipeptidase activity
EPY81_09715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPY81_09720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPY81_09730	COG0789	Transcriptional regulator
EPY81_09740	COG1279	arginine transmembrane transporter activity
EPY81_09745	COG0583	DNA-binding transcription factor activity
EPY81_09790	COG0741	lytic transglycosylase activity
EPY81_09790	COG1388	LysM domain
EPY81_09790	COG1388	LysM domain
EPY81_09790	COG0741	lytic transglycosylase activity
EPY81_09795	COG4166	transmembrane transport
EPY81_09800	COG4174	ABC transporter (Permease)
EPY81_09805	COG4239	(ABC) transporter, permease
EPY81_09810	COG4172	Belongs to the ABC transporter superfamily
EPY81_09835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EPY81_09845	COG5001	Diguanylate cyclase
EPY81_09845	COG3706	GGDEF domain
EPY81_09845	COG2203	Gaf domain
EPY81_09845	COG4251	negative regulation of phosphorylation
EPY81_09855	COG1902	pentaerythritol trinitrate reductase activity
EPY81_09855	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPY81_09865	COG0582	viral genome integration into host DNA
EPY81_09970	COG2814	Major facilitator Superfamily
EPY81_09985	COG1230	cation diffusion facilitator family transporter
EPY81_09995	COG2059	Chromate
EPY81_10030	COG4269	membrane
EPY81_10075	COG1113	amino acid transport
EPY81_10085	COG0531	amino acid
EPY81_10105	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_10125	COG1113	amino acid transport
EPY81_10130	COG2831	hemolysin activation secretion protein
EPY81_10135	COG3210	domain, Protein
EPY81_10155	COG0697	spore germination
EPY81_10160	COG2721	sulfolactate sulfo-lyase activity
EPY81_10165	COG2271	Major facilitator Superfamily
EPY81_10170	COG4948	Mandelate Racemase Muconate Lactonizing
EPY81_10180	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_10185	COG2186	Transcriptional regulator
EPY81_10210	COG1960	acyl-CoA dehydrogenase activity
EPY81_10220	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_10225	COG1024	Enoyl-CoA hydratase
EPY81_10230	COG2814	Major facilitator Superfamily
EPY81_10250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPY81_10265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EPY81_10285	COG1944	ATP diphosphatase activity
EPY81_10315	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EPY81_10320	COG2072	flavoprotein involved in K transport
EPY81_10335	COG1309	transcriptional regulator
EPY81_10340	COG1741	Belongs to the pirin family
EPY81_10350	COG2252	PERMEase
EPY81_10355	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EPY81_10360	COG3038	cytochrome b561
EPY81_10370	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EPY81_10380	COG0527	aspartate kinase activity
EPY81_10430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EPY81_10435	COG4197	protein conserved in bacteria, prophage-related
EPY81_10525	COG5410	chromosome segregation
EPY81_10540	COG3567	Phage-associated protein, HI1409 family
EPY81_10560	COG3566	protein conserved in bacteria
EPY81_10665	COG2194	sulfuric ester hydrolase activity
EPY81_10680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPY81_10695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPY81_10710	COG0667	Aldo Keto reductase
EPY81_10725	COG1765	OsmC-like protein
EPY81_10740	COG0542	response to heat
EPY81_10775	COG2885	chlorophyll binding
EPY81_10785	COG0625	glutathione transferase activity
EPY81_10815	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EPY81_10835	COG3634	alkyl hydroperoxide reductase activity
EPY81_10860	COG1643	Atp-dependent helicase
EPY81_10875	COG2814	Major facilitator Superfamily
EPY81_10880	COG3135	benzoate transporter
EPY81_10885	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_10890	COG0633	Ferredoxin
EPY81_10890	COG0543	2 iron, 2 sulfur cluster binding
EPY81_10895	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EPY81_10900	COG4638	Rieske (2fe-2S)
EPY81_10910	COG0583	DNA-binding transcription factor activity
EPY81_10920	COG2871	sodium ion transport
EPY81_11005	COG1570	exodeoxyribonuclease VII activity
EPY81_11060	COG1560	Kdo2-lipid A biosynthetic process
EPY81_11065	COG1278	Cold shock
EPY81_11090	COG1011	Hydrolase
EPY81_11095	COG2226	methyltransferase
EPY81_11125	COG1309	transcriptional regulator
EPY81_11170	COG0668	transmembrane transport
EPY81_11180	COG2814	Major facilitator Superfamily
EPY81_11235	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EPY81_11245	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EPY81_11250	COG1137	ATPase activity
EPY81_11255	COG1538	Outer membrane efflux protein
EPY81_11285	COG4122	O-methyltransferase activity
EPY81_11295	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EPY81_11310	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPY81_11325	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EPY81_11330	COG0531	amino acid
EPY81_11335	COG1522	sequence-specific DNA binding
EPY81_11350	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EPY81_11360	COG1469	GTP cyclohydrolase I activity
EPY81_11380	COG1733	regulation of RNA biosynthetic process
EPY81_11385	COG0753	catalase activity
EPY81_11390	COG3038	cytochrome b561
EPY81_11500	COG3220	belongs to the UPF0276 family
EPY81_11510	COG1595	DNA-templated transcription, initiation
EPY81_11525	COG1914	H( )-stimulated, divalent metal cation uptake system
EPY81_11545	COG4770	biotin carboxylase activity
EPY81_11550	COG0038	chloride channel
EPY81_11555	COG2831	hemolysin activation secretion protein
EPY81_11560	COG3210	domain, Protein
EPY81_11595	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPY81_11600	COG1063	alcohol dehydrogenase
EPY81_11615	COG0439	Biotin carboxylase
EPY81_11620	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPY81_11625	COG1733	regulation of RNA biosynthetic process
EPY81_11635	COG0864	Transcriptional regulator
EPY81_11645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPY81_11650	COG1116	anion transmembrane transporter activity
EPY81_11665	COG0477	Major facilitator Superfamily
EPY81_11700	COG0666	response to abiotic stimulus
EPY81_11705	COG0590	tRNA wobble adenosine to inosine editing
EPY81_11710	COG2807	transmembrane transport
EPY81_11725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPY81_11730	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EPY81_11740	COG0789	Transcriptional regulator
EPY81_11760	COG1760	l-serine dehydratase
EPY81_11765	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_11765	COG2030	dehydratase
EPY81_11770	COG3396	Phenylacetate-CoA oxygenase
EPY81_11775	COG3460	Phenylacetate-CoA oxygenase
EPY81_11780	COG3396	Phenylacetate-CoA oxygenase
EPY81_11785	COG2151	metal-sulfur cluster biosynthetic enzyme
EPY81_11790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPY81_11795	COG1024	Enoyl-CoA hydratase
EPY81_11800	COG1024	Enoyl-CoA hydratase
EPY81_11805	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPY81_11810	COG0183	Belongs to the thiolase family
EPY81_11815	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EPY81_11820	COG3327	negative regulation of DNA-templated transcription, initiation
EPY81_11830	COG2050	protein possibly involved in aromatic compounds catabolism
EPY81_11865	COG0583	DNA-binding transcription factor activity
EPY81_11875	COG1414	Transcriptional regulator
EPY81_11880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPY81_11900	COG1840	ABC-type Fe3 transport system, periplasmic component
EPY81_11905	COG3842	ATPase activity
EPY81_11920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EPY81_11925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPY81_11930	COG2814	Major facilitator Superfamily
EPY81_11935	COG1960	acyl-CoA dehydrogenase activity
EPY81_11950	COG1024	Enoyl-CoA hydratase
EPY81_11960	COG2814	Major facilitator Superfamily
EPY81_11970	COG0183	Belongs to the thiolase family
EPY81_11975	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPY81_11980	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_11985	COG1024	Enoyl-CoA hydratase
EPY81_11990	COG1960	acyl-CoA dehydrogenase activity
EPY81_11995	COG2814	Major facilitator Superfamily
EPY81_12000	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EPY81_12005	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EPY81_12015	COG2814	Major facilitator Superfamily
EPY81_12025	COG1960	acyl-CoA dehydrogenase activity
EPY81_12040	COG0583	DNA-binding transcription factor activity
EPY81_12050	COG4770	biotin carboxylase activity
EPY81_12055	COG1024	Enoyl-CoA hydratase
EPY81_12060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EPY81_12065	COG1960	acyl-CoA dehydrogenase activity
EPY81_12070	COG1309	transcriptional regulator
EPY81_12075	COG0318	PFAM AMP-dependent synthetase and ligase
EPY81_12090	COG2814	Major facilitator Superfamily
EPY81_12105	COG0583	DNA-binding transcription factor activity
EPY81_12165	COG0776	regulation of translation
EPY81_12255	COG4373	Mu-like prophage FluMu protein gp28
EPY81_12260	COG4383	Mu-like prophage protein gp29
EPY81_12265	COG2369	cell adhesion
EPY81_12400	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_12420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EPY81_12440	COG0784	Response regulator, receiver
EPY81_12440	COG2205	protein histidine kinase activity
EPY81_12460	COG0765	amino acid transport
EPY81_12465	COG0765	amino acid transport
EPY81_12475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPY81_12480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPY81_12490	COG1280	lysine exporter protein (LysE YggA)
EPY81_12500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPY81_12505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPY81_12510	COG1045	serine acetyltransferase
EPY81_12520	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_12525	COG0583	DNA-binding transcription factor activity
EPY81_12545	COG0625	glutathione transferase activity
EPY81_12550	COG0625	glutathione transferase activity
EPY81_12555	COG0583	DNA-binding transcription factor activity
EPY81_12565	COG1346	cytolysis
EPY81_12590	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
EPY81_12595	COG3052	prosthetic group binding
EPY81_12615	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EPY81_12635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPY81_12645	COG1294	oxidase, subunit
EPY81_12650	COG1271	oxidase subunit
EPY81_12670	COG0477	Major facilitator Superfamily
EPY81_12680	COG4521	taurine ABC transporter
EPY81_12685	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EPY81_12690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPY81_12695	COG2175	clavaminate synthase activity
EPY81_12705	COG1953	Uracil, thiamine, allantoin
EPY81_12715	COG0583	DNA-binding transcription factor activity
EPY81_12725	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EPY81_12740	COG0640	Transcriptional regulator
EPY81_12750	COG0798	PFAM Bile acid sodium symporter
EPY81_12755	COG0431	NADPH-dependent FMN reductase
EPY81_12760	COG0583	DNA-binding transcription factor activity
EPY81_12775	COG3634	alkyl hydroperoxide reductase activity
EPY81_12810	COG1301	dicarboxylic acid transport
EPY81_12815	COG0436	Aminotransferase
EPY81_12825	COG0386	Belongs to the glutathione peroxidase family
EPY81_12865	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EPY81_12890	COG0012	GTP binding
EPY81_12895	COG2011	ABC-type metal ion transport system permease component
EPY81_12900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EPY81_12910	COG1464	Belongs to the NlpA lipoprotein family
EPY81_12940	COG0765	amino acid transport
EPY81_12945	COG0765	amino acid transport
EPY81_12950	COG1126	abc transporter atp-binding protein
EPY81_12960	COG1522	sequence-specific DNA binding
EPY81_12975	COG1309	transcriptional regulator
EPY81_12990	COG0583	DNA-binding transcription factor activity
EPY81_13000	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EPY81_13010	COG0697	spore germination
EPY81_13015	COG0583	DNA-binding transcription factor activity
EPY81_13050	COG3539	Fimbrial protein
EPY81_13075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EPY81_13075	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EPY81_13120	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPY81_13130	COG2353	YceI-like domain
EPY81_13140	COG3698	Phosphodiester glycosidase
EPY81_13155	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EPY81_13160	COG0506	proline dehydrogenase activity
EPY81_13160	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EPY81_13160	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EPY81_13170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPY81_13175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPY81_13195	COG1132	(ABC) transporter
EPY81_13200	COG3122	Protein conserved in bacteria
EPY81_13205	COG3619	membrane
EPY81_13215	COG0640	Transcriptional regulator
EPY81_13225	COG2850	peptidyl-arginine hydroxylation
EPY81_13230	COG0424	maF-like protein
EPY81_13255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPY81_13265	COG3178	'Phosphotransferase
EPY81_13270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EPY81_13280	COG1192	Involved in chromosome partitioning
EPY81_13285	COG1475	DNA binding
EPY81_13290	COG0811	peptide transport
EPY81_13300	COG1132	(ABC) transporter
EPY81_13305	COG1663	tetraacyldisaccharide 4'-kinase activity
EPY81_13325	COG0084	hydrolase, TatD family'
EPY81_13390	COG0776	regulation of translation
EPY81_13405	COG2431	L-lysine efflux transmembrane transporter activity
EPY81_13420	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EPY81_13425	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EPY81_13470	COG4166	transmembrane transport
EPY81_13475	COG0339	signal peptide processing
EPY81_13480	COG0601	transmembrane transport
EPY81_13520	COG0702	epimerase
EPY81_13525	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPY81_13545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EPY81_13575	COG0316	Belongs to the HesB IscA family
EPY81_13580	COG0822	iron-sulfur transferase activity
EPY81_13605	COG0776	regulation of translation
EPY81_13610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPY81_13615	COG2207	Transcriptional regulator
EPY81_13620	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPY81_13625	COG1960	acyl-CoA dehydrogenase activity
EPY81_13630	COG1960	acyl-CoA dehydrogenase activity
EPY81_13645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EPY81_13675	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EPY81_13695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPY81_13700	COG0730	response to heat
EPY81_13725	COG4773	Receptor
EPY81_13730	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPY81_13790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EPY81_13805	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EPY81_13810	COG0583	DNA-binding transcription factor activity
EPY81_13840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPY81_13850	COG0133	tryptophan synthase activity
EPY81_13885	COG3706	GGDEF domain
EPY81_13900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EPY81_13905	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EPY81_13910	COG0022	dehydrogenase e1 component
EPY81_13915	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPY81_13920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPY81_13930	COG1063	alcohol dehydrogenase
EPY81_13935	COG3781	membrane
EPY81_13945	COG3453	Protein conserved in bacteria
EPY81_13945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPY81_13955	COG0730	response to heat
EPY81_13975	COG3708	Transcriptional regulator
EPY81_13975	COG2207	Transcriptional regulator
EPY81_13980	COG1733	regulation of RNA biosynthetic process
EPY81_13985	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EPY81_13995	COG0477	Major facilitator Superfamily
EPY81_14005	COG1027	Aspartate ammonia-lyase
EPY81_14020	COG0583	DNA-binding transcription factor activity
EPY81_14025	COG0583	DNA-binding transcription factor activity
EPY81_14030	COG0183	Belongs to the thiolase family
EPY81_14035	COG2031	fatty acid transporter
EPY81_14050	COG0583	DNA-binding transcription factor activity
EPY81_14090	COG2610	gluconate transmembrane transporter activity
EPY81_14095	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_14100	COG2207	Transcriptional regulator
EPY81_14120	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_14130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPY81_14145	COG0543	2 iron, 2 sulfur cluster binding
EPY81_14145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPY81_14150	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EPY81_14155	COG4638	Rieske (2fe-2S)
EPY81_14165	COG0725	ABC transporter, periplasmic molybdate-binding protein
EPY81_14170	COG4149	molybdate abc transporter
EPY81_14175	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EPY81_14180	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_14185	COG3433	isochorismatase activity
EPY81_14185	COG1535	isochorismatase
EPY81_14240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPY81_14245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPY81_14250	COG0745	RESPONSE REGULATOR receiver
EPY81_14255	COG2205	protein histidine kinase activity
EPY81_14265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPY81_14285	COG0753	catalase activity
EPY81_14320	COG3539	Fimbrial protein
EPY81_14400	COG4628	conserved protein (DUF2132)
EPY81_14410	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EPY81_14465	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EPY81_14570	COG0318	PFAM AMP-dependent synthetase and ligase
EPY81_14580	COG1960	acyl-CoA dehydrogenase activity
EPY81_14590	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_14595	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_14600	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_14605	COG0583	DNA-binding transcription factor activity
EPY81_14610	COG1309	transcriptional regulator
EPY81_14650	COG1902	pentaerythritol trinitrate reductase activity
EPY81_14650	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPY81_14670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPY81_14680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPY81_14695	COG2186	Transcriptional regulator
EPY81_14700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPY81_14710	COG2233	PERMEase
EPY81_14715	COG2351	hydroxyisourate hydrolase activity
EPY81_14720	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_14740	COG2186	Transcriptional regulator
EPY81_14750	COG0583	DNA-binding transcription factor activity
EPY81_14755	COG4948	Mandelate Racemase Muconate Lactonizing
EPY81_14760	COG4829	muconolactone delta-isomerase
EPY81_14770	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EPY81_14775	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EPY81_14780	COG0183	Belongs to the thiolase family
EPY81_14785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPY81_14790	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_14800	COG3733	amine oxidase
EPY81_14810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPY81_14820	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_14830	COG4638	Rieske (2fe-2S)
EPY81_14850	COG0154	amidase activity
EPY81_14860	COG2814	Major facilitator Superfamily
EPY81_14885	COG1960	acyl-CoA dehydrogenase activity
EPY81_14890	COG0583	DNA-binding transcription factor activity
EPY81_14895	COG1414	Transcriptional regulator
EPY81_14910	COG2391	methyltransferase activity
EPY81_14920	COG4993	Dehydrogenase
EPY81_14925	COG3659	wide pore channel activity
EPY81_14930	COG3420	alginic acid biosynthetic process
EPY81_14935	COG0710	3-dehydroquinate dehydratase activity
EPY81_14940	COG3485	protocatechuate 3,4-dioxygenase
EPY81_14945	COG3485	protocatechuate 3,4-dioxygenase
EPY81_14950	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EPY81_14955	COG2271	Major facilitator Superfamily
EPY81_14960	COG0596	Alpha beta hydrolase
EPY81_14965	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EPY81_14970	COG0183	Belongs to the thiolase family
EPY81_14975	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EPY81_14980	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EPY81_14990	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EPY81_14995	COG4773	Receptor
EPY81_15005	COG2323	membrane
EPY81_15010	COG0148	phosphopyruvate hydratase activity
EPY81_15050	COG1902	pentaerythritol trinitrate reductase activity
EPY81_15050	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPY81_15075	COG0542	response to heat
EPY81_15080	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EPY81_15110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EPY81_15115	COG0569	domain protein
EPY81_15120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPY81_15135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPY81_15145	COG1585	Membrane protein implicated in regulation of membrane protease activity
EPY81_15160	COG1294	oxidase, subunit
EPY81_15165	COG4890	Cyd operon protein YbgT
EPY81_15190	COG0552	protein localization to endoplasmic reticulum
EPY81_15215	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EPY81_15215	COG0517	IMP dehydrogenase activity
EPY81_15220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPY81_15225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EPY81_15235	COG0583	DNA-binding transcription factor activity
EPY81_15240	COG0024	Methionine aminopeptidase
EPY81_15250	COG3193	protein, possibly involved in utilization of glycolate and propanediol
EPY81_15270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPY81_15270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPY81_15275	COG1105	Belongs to the carbohydrate kinase PfkB family
EPY81_15280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPY81_15280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPY81_15280	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EPY81_15315	COG0659	secondary active sulfate transmembrane transporter activity
EPY81_15335	COG1113	amino acid transport
EPY81_15345	COG1522	sequence-specific DNA binding
EPY81_15360	COG1011	Hydrolase
EPY81_15365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EPY81_15375	COG2137	regulation of response to DNA damage stimulus
EPY81_15390	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPY81_15425	COG0575	Belongs to the CDS family
EPY81_15430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EPY81_15455	COG3852	Histidine kinase
EPY81_15460	COG2204	response regulator
EPY81_15530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EPY81_15555	COG0697	spore germination
EPY81_15560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPY81_15570	COG0303	'Molybdopterin
EPY81_15575	COG0315	cyclic pyranopterin monophosphate synthase activity
EPY81_15575	COG0521	Mo-molybdopterin cofactor biosynthetic process
EPY81_15590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EPY81_15595	COG0243	molybdopterin cofactor binding
EPY81_15605	COG0243	molybdopterin cofactor binding
EPY81_15610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPY81_15615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPY81_15615	COG2146	nitrite reductase [NAD(P)H] activity
EPY81_15630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPY81_15630	COG1116	anion transmembrane transporter activity
EPY81_15635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPY81_15640	COG2423	ornithine cyclodeaminase activity
EPY81_15645	COG4264	IucA IucC family
EPY81_15655	COG4264	IucA IucC family
EPY81_15680	COG0511	ligase activity, forming carbon-carbon bonds
EPY81_15695	COG2814	Major facilitator Superfamily
EPY81_15750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EPY81_15770	COG1335	isochorismatase
EPY81_15785	COG1454	alcohol dehydrogenase
EPY81_15790	COG0824	Thioesterase
EPY81_15800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EPY81_15830	COG2030	dehydratase
EPY81_15835	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_15840	COG0183	Belongs to the thiolase family
EPY81_15850	COG0583	DNA-binding transcription factor activity
EPY81_15855	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EPY81_15865	COG1522	sequence-specific DNA binding
EPY81_15870	COG3135	benzoate transporter
EPY81_15900	COG0589	response to stress
EPY81_15905	COG0488	(ABC) transporter
EPY81_15940	COG0583	DNA-binding transcription factor activity
EPY81_15965	COG3772	lysozyme
EPY81_16020	COG4774	siderophore transport
EPY81_16025	COG4772	TonB-dependent receptor
EPY81_16050	COG1605	Chorismate mutase
EPY81_16090	COG0308	aminopeptidase N
EPY81_16115	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPY81_16120	COG1454	alcohol dehydrogenase
EPY81_16140	COG0531	amino acid
EPY81_16145	COG4303	Ethanolamine ammonia lyase large subunit
EPY81_16150	COG4302	ethanolamine ammonia-lyase activity
EPY81_16155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EPY81_16155	COG0519	Catalyzes the synthesis of GMP from XMP
EPY81_16160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPY81_16170	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPY81_16185	COG0697	spore germination
EPY81_16190	COG1923	regulation of RNA biosynthetic process
EPY81_16200	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EPY81_16205	COG0802	atpase or kinase
EPY81_16225	COG1187	pseudouridine synthase activity
EPY81_16240	COG0583	DNA-binding transcription factor activity
EPY81_16345	COG2369	cell adhesion
EPY81_16365	COG4373	Mu-like prophage FluMu protein gp28
EPY81_16400	COG0681	Belongs to the peptidase S26 family
EPY81_16425	COG3267	Type II secretory pathway component ExeA
EPY81_16425	COG3409	Peptidoglycan-binding domain 1 protein
EPY81_16450	COG0776	regulation of translation
EPY81_16495	COG2814	Major facilitator Superfamily
EPY81_16500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPY81_16535	COG0729	surface antigen
EPY81_16540	COG0477	Major facilitator Superfamily
EPY81_16555	COG0174	glutamine synthetase
EPY81_16560	COG0745	RESPONSE REGULATOR receiver
EPY81_16565	COG2205	protein histidine kinase activity
EPY81_16570	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EPY81_16575	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EPY81_16580	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EPY81_16590	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EPY81_16605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPY81_16610	COG1960	acyl-CoA dehydrogenase activity
EPY81_16625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPY81_16630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPY81_16635	COG2890	protein-(glutamine-N5) methyltransferase activity
EPY81_16650	COG0583	DNA-binding transcription factor activity
EPY81_16665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPY81_16675	COG3658	cytochrome
EPY81_16680	COG1215	transferase activity, transferring glycosyl groups
EPY81_16685	COG1649	PFAM Uncharacterised BCR, COG1649
EPY81_16685	COG0726	polysaccharide deacetylase
EPY81_16715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EPY81_16720	COG1845	cytochrome c oxidase, subunit III
EPY81_16725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EPY81_16750	COG0305	Participates in initiation and elongation during chromosome replication
EPY81_16755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPY81_16765	COG1305	Transglutaminase-like
EPY81_16775	COG2308	Evidence 4 Homologs of previously reported genes of
EPY81_16805	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EPY81_16815	COG0151	Belongs to the GarS family
EPY81_16825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EPY81_16830	COG2011	ABC-type metal ion transport system permease component
EPY81_16835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPY81_16845	COG1301	dicarboxylic acid transport
EPY81_16875	COG1794	racemase activity, acting on amino acids and derivatives
EPY81_16890	COG0745	RESPONSE REGULATOR receiver
EPY81_16895	COG0642	Histidine kinase
EPY81_16900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EPY81_16910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EPY81_16950	COG2351	hydroxyisourate hydrolase activity
EPY81_16960	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EPY81_16960	COG3008	intermembrane lipid transfer
EPY81_16965	COG2995	paraquat-inducible protein a
EPY81_16975	COG2985	domain, Protein
EPY81_16985	COG1309	transcriptional regulator
EPY81_17000	COG0475	glutathione-regulated potassium exporter activity
EPY81_17000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPY81_17005	COG0786	glutamate:sodium symporter activity
EPY81_17010	COG3243	poly(R)-hydroxyalkanoic acid synthase
EPY81_17025	COG1278	Cold shock
EPY81_17080	COG1610	YqeY-like protein
EPY81_17085	COG4783	chaperone-mediated protein folding
EPY81_17110	COG1286	toxin biosynthetic process
EPY81_17140	COG0778	Nitroreductase
EPY81_17150	COG0513	Belongs to the DEAD box helicase family
EPY81_17170	COG2363	Small membrane protein
EPY81_17200	COG4650	regulator
EPY81_17205	COG1234	tRNA 3'-trailer cleavage
EPY81_17210	COG1690	Belongs to the RtcB family
EPY81_17230	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPY81_17240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EPY81_17255	COG1960	acyl-CoA dehydrogenase activity
EPY81_17260	COG1301	dicarboxylic acid transport
EPY81_17275	COG3139	Protein of unknown function (DUF1315)
EPY81_17280	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EPY81_17285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPY81_17295	COG0494	nUDIX hydrolase
EPY81_17305	COG0642	Histidine kinase
EPY81_17310	COG0745	RESPONSE REGULATOR receiver
EPY81_17330	COG1720	tRNA m6t6A37 methyltransferase activity
EPY81_17340	COG0384	phenazine biosynthesis protein PhzF
EPY81_17345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPY81_17355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPY81_17365	COG4598	ABC transporter
EPY81_17370	COG4160	amino acid transport
EPY81_17375	COG4215	(ABC) transporter
EPY81_17380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPY81_17390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPY81_17435	COG1131	(ABC) transporter
EPY81_17440	COG0842	Transport permease protein
EPY81_17455	COG0772	Belongs to the SEDS family
EPY81_17460	COG2951	lytic endotransglycosylase activity
EPY81_17485	COG2207	Transcriptional regulator
EPY81_17500	COG0052	Belongs to the universal ribosomal protein uS2 family
EPY81_17505	COG0024	Methionine aminopeptidase
EPY81_17515	COG2223	nitrite transmembrane transporter activity
EPY81_17525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPY81_17530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EPY81_17535	COG1960	acyl-CoA dehydrogenase activity
EPY81_17550	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EPY81_17555	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EPY81_17560	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EPY81_17580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPY81_17585	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EPY81_17590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EPY81_17625	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EPY81_17635	COG0174	glutamine synthetase
EPY81_17640	COG3104	oligopeptide transport
EPY81_17650	COG0582	viral genome integration into host DNA
EPY81_17670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EPY81_17695	COG3179	chitinase
EPY81_17735	COG2314	TM2 domain
EPY81_17795	COG3566	protein conserved in bacteria
EPY81_17815	COG3567	Phage-associated protein, HI1409 family
EPY81_17820	COG5410	chromosome segregation
EPY81_17910	COG4197	protein conserved in bacteria, prophage-related
EPY81_17915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EPY81_17965	COG0512	Glutamine amidotransferase of anthranilate synthase
EPY81_17970	COG0308	aminopeptidase N
EPY81_17975	COG4771	TonB-dependent receptor
EPY81_17990	COG2840	Smr protein MutS2
EPY81_18000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EPY81_18030	COG3739	integral membrane protein
EPY81_18050	COG1169	isochorismate synthase
EPY81_18060	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EPY81_18070	COG1132	(ABC) transporter
EPY81_18085	COG1535	isochorismatase
EPY81_18085	COG3433	isochorismatase activity
EPY81_18090	COG1021	2,3-dihydroxybenzoate-AMP ligase
EPY81_18095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPY81_18105	COG4774	siderophore transport
EPY81_18110	COG4607	ABC-type enterochelin transport system periplasmic component
EPY81_18115	COG4604	ABC transporter, ATP-binding protein
EPY81_18120	COG4605	iron ion homeostasis
EPY81_18125	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPY81_18130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPY81_18145	COG1741	Belongs to the pirin family
EPY81_18205	COG3621	Patatin-like phospholipase
EPY81_18245	COG0582	viral genome integration into host DNA
EPY81_18255	COG2879	small protein
EPY81_18260	COG1966	Carbon starvation protein
EPY81_18265	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EPY81_18300	COG2211	Major facilitator Superfamily
EPY81_18305	COG1067	ATP-dependent peptidase activity
EPY81_18310	COG0583	DNA-binding transcription factor activity
EPY81_18335	COG1686	Belongs to the peptidase S11 family
EPY81_18340	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EPY81_18380	COG0616	signal peptide processing
EPY81_18385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPY81_18395	COG0573	inorganic phosphate transmembrane transporter activity
EPY81_18400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EPY81_18405	COG1113	amino acid transport
EPY81_18410	COG3961	Belongs to the TPP enzyme family
EPY81_18415	COG1522	sequence-specific DNA binding
EPY81_18425	COG0076	glutamate decarboxylase activity
EPY81_18430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPY81_18445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPY81_18480	COG0352	thiamine-phosphate diphosphorylase activity
EPY81_18505	COG0612	Peptidase, M16
EPY81_18520	COG0583	DNA-binding transcription factor activity
EPY81_18525	COG0477	Major facilitator Superfamily
EPY81_18540	COG1187	pseudouridine synthase activity
EPY81_18555	COG1686	Belongs to the peptidase S11 family
EPY81_18560	COG1252	NADH dehydrogenase
EPY81_18570	COG0415	Belongs to the DNA photolyase family
EPY81_18585	COG1215	transferase activity, transferring glycosyl groups
EPY81_18600	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EPY81_18615	COG2070	2-Nitropropane dioxygenase
EPY81_18660	COG2962	Rard protein
EPY81_18670	COG0556	nucleotide-excision repair
EPY81_18690	COG0436	Aminotransferase
EPY81_18720	COG4221	oxidoreductase activity
EPY81_18730	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EPY81_18735	COG1381	Involved in DNA repair and RecF pathway recombination
EPY81_18745	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EPY81_18750	COG0571	ribonuclease III activity
EPY81_18760	COG0681	Belongs to the peptidase S26 family
EPY81_18765	COG0481	GTPase activity
EPY81_18770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPY81_18780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPY81_18800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EPY81_18805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPY81_18810	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EPY81_18820	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EPY81_18825	COG4208	sulfate ABC transporter
EPY81_18830	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EPY81_18835	COG0583	DNA-binding transcription factor activity
EPY81_18840	COG4625	pathogenesis
EPY81_18855	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EPY81_18870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EPY81_18885	COG1056	cytidyltransferase-related domain
EPY81_18885	COG1051	belongs to the nudix hydrolase family
EPY81_18890	COG1024	Enoyl-CoA hydratase
EPY81_18895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EPY81_18900	COG2814	Major facilitator Superfamily
EPY81_18905	COG0047	phosphoribosylformylglycinamidine synthase activity
EPY81_18905	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EPY81_18925	COG1473	amidohydrolase
EPY81_18930	COG0824	Thioesterase
EPY81_18950	COG0823	Involved in the tonB-independent uptake of proteins
EPY81_18970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPY81_19010	COG0628	permease
EPY81_19020	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EPY81_19025	COG0596	Alpha beta hydrolase
EPY81_19030	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPY81_19030	COG0616	signal peptide processing
EPY81_19040	COG0658	competence protein
EPY81_19040	COG2333	competence protein COMEC
EPY81_19045	COG1136	(ABC) transporter
EPY81_19050	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPY81_19080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPY81_19110	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EPY81_19115	COG1280	lysine exporter protein (LysE YggA)
EPY81_19125	COG0019	diaminopimelate decarboxylase activity
EPY81_19135	COG1113	amino acid transport
EPY81_19140	COG1115	amino acid carrier protein
EPY81_19155	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EPY81_19165	COG3339	Conserved Protein
EPY81_19170	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EPY81_19175	COG0243	molybdopterin cofactor binding
EPY81_19180	COG1929	Belongs to the glycerate kinase type-1 family
EPY81_19195	COG0778	Nitroreductase
EPY81_19205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPY81_19250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPY81_19255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPY81_19280	COG0741	lytic transglycosylase activity
EPY81_19300	COG0584	glycerophosphoryl diester phosphodiesterase
EPY81_19330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EPY81_19335	COG1597	lipid kinase activity
EPY81_19350	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EPY81_19355	COG0477	Major facilitator Superfamily
EPY81_19365	COG2264	protein methyltransferase activity
EPY81_19410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EPY81_19415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPY81_19450	COG0505	Belongs to the CarA family
EPY81_19465	COG1309	transcriptional regulator
EPY81_19470	COG0251	oxidation-reduction process
EPY81_19480	COG0589	response to stress
EPY81_19500	COG2843	Capsule synthesis protein