locus-tag	class	description
C2U64_00020	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C2U64_00045	COG3316	Transposase and inactivated derivatives
C2U64_00060	COG1660	Displays ATPase and GTPase activities
C2U64_00095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U64_00125	COG3316	Transposase and inactivated derivatives
C2U64_00140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U64_00230	COG3316	Transposase and inactivated derivatives
C2U64_00255	COG2184	nucleotidyltransferase activity
C2U64_00290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U64_00330	COG0582	viral genome integration into host DNA
C2U64_00390	COG2801	Transposase and inactivated derivatives
C2U64_00410	COG1570	exodeoxyribonuclease VII activity
C2U64_00420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U64_00430	COG2801	Transposase and inactivated derivatives
C2U64_00440	COG2801	Transposase and inactivated derivatives
C2U64_00450	COG3173	Aminoglycoside phosphotransferase
C2U64_00475	COG2801	Transposase and inactivated derivatives
C2U64_00490	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U64_00495	COG3657	addiction module killer protein
C2U64_00520	COG2801	Transposase and inactivated derivatives
C2U64_00530	COG2801	Transposase and inactivated derivatives
C2U64_00555	COG3316	Transposase and inactivated derivatives
C2U64_00570	COG3077	Addiction module antitoxin, RelB DinJ family
C2U64_00585	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U64_00615	COG3316	Transposase and inactivated derivatives
C2U64_00640	COG3316	Transposase and inactivated derivatives
C2U64_00645	COG0659	secondary active sulfate transmembrane transporter activity
C2U64_00650	COG0589	response to stress
C2U64_00665	COG2130	NADP-dependent
C2U64_00680	COG0582	viral genome integration into host DNA
C2U64_00710	COG0604	alcohol dehydrogenase
C2U64_00740	COG1192	Involved in chromosome partitioning
C2U64_00745	COG1475	DNA binding
C2U64_00750	COG1785	Belongs to the alkaline phosphatase family
C2U64_00860	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
C2U64_00895	COG2184	nucleotidyltransferase activity
C2U64_00945	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C2U64_00945	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C2U64_00975	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C2U64_00995	COG2801	Transposase and inactivated derivatives
C2U64_01020	COG4221	oxidoreductase activity
C2U64_01025	COG0583	DNA-binding transcription factor activity
C2U64_01030	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C2U64_01035	COG0604	alcohol dehydrogenase
C2U64_01035	COG3321	synthase
C2U64_01045	COG0697	spore germination
C2U64_01050	COG0477	Major facilitator Superfamily
C2U64_01080	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C2U64_01095	COG1979	alcohol dehydrogenase
C2U64_01105	COG1902	pentaerythritol trinitrate reductase activity
C2U64_01115	COG1309	transcriptional regulator
C2U64_01135	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C2U64_01160	COG0659	secondary active sulfate transmembrane transporter activity
C2U64_01165	COG0589	response to stress
C2U64_01185	COG0592	DNA-directed DNA polymerase activity
C2U64_01195	COG0187	DNA topoisomerase II activity
C2U64_01210	COG0488	(ABC) transporter
C2U64_01235	COG0596	Alpha beta hydrolase
C2U64_01240	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C2U64_01245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U64_01280	COG0625	glutathione transferase activity
C2U64_01290	COG0733	neurotransmitter:sodium symporter activity
C2U64_01330	COG2233	PERMEase
C2U64_01345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U64_01380	COG2814	Major facilitator Superfamily
C2U64_01385	COG0656	L-ascorbic acid biosynthetic process
C2U64_01390	COG0583	DNA-binding transcription factor activity
C2U64_01405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U64_01410	COG1064	alcohol dehydrogenase
C2U64_01415	COG2818	Glycosylase
C2U64_01430	COG1194	a g-specific adenine glycosylase
C2U64_01445	COG5487	UPF0391 membrane protein
C2U64_01450	COG2983	Belongs to the UPF0260 family
C2U64_01455	COG2133	pyrroloquinoline quinone binding
C2U64_01460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2U64_01465	COG2116	formate transmembrane transporter activity
C2U64_01485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U64_01490	COG1335	isochorismatase
C2U64_01495	COG0385	Bile acid
C2U64_01500	COG0534	Mate efflux family protein
C2U64_01505	COG1683	Conserved Protein
C2U64_01520	COG0346	lactoylglutathione lyase activity
C2U64_01525	COG0625	glutathione transferase activity
C2U64_01535	COG1113	amino acid transport
C2U64_01545	COG0523	cobalamin synthesis protein
C2U64_01555	COG2188	Transcriptional regulator
C2U64_01585	COG0010	Belongs to the arginase family
C2U64_01635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2U64_01645	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2U64_01650	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2U64_01760	COG0534	Mate efflux family protein
C2U64_01765	COG0436	Aminotransferase
C2U64_01770	COG2733	membrane
C2U64_01785	COG2918	glutathione biosynthetic process
C2U64_01795	COG3501	Rhs element vgr protein
C2U64_01840	COG3150	esterase
C2U64_01850	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C2U64_01860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U64_01870	COG2233	PERMEase
C2U64_01875	COG2351	hydroxyisourate hydrolase activity
C2U64_01910	COG3706	GGDEF domain
C2U64_01915	COG2826	transposase and inactivated derivatives, IS30 family
C2U64_01930	COG1393	Belongs to the ArsC family
C2U64_01935	COG0708	Exodeoxyribonuclease III
C2U64_01955	COG0189	ligase activity
C2U64_01975	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2U64_01985	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2U64_02000	COG4942	peptidase
C2U64_02010	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U64_02020	COG2119	membrane
C2U64_02025	COG4774	siderophore transport
C2U64_02030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U64_02030	COG0426	domain, Protein
C2U64_02050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2U64_02070	COG1902	pentaerythritol trinitrate reductase activity
C2U64_02075	COG1519	Transferase
C2U64_02080	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U64_02085	COG0668	transmembrane transport
C2U64_02095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U64_02100	COG1335	isochorismatase
C2U64_02105	COG1522	sequence-specific DNA binding
C2U64_02110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U64_02130	COG0784	Response regulator, receiver
C2U64_02130	COG2205	protein histidine kinase activity
C2U64_02130	COG2198	Histidine kinase
C2U64_02135	COG3162	membrane
C2U64_02140	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U64_02150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U64_02160	COG3706	GGDEF domain
C2U64_02175	COG1309	transcriptional regulator
C2U64_02195	COG0300	oxidoreductase activity
C2U64_02200	COG0789	Transcriptional regulator
C2U64_02205	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2U64_02205	COG0352	thiamine-phosphate diphosphorylase activity
C2U64_02205	COG0351	phosphomethylpyrimidine kinase
C2U64_02215	COG2814	Major facilitator Superfamily
C2U64_02280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U64_02295	COG0641	radical SAM
C2U64_02315	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2U64_02325	COG1113	amino acid transport
C2U64_02335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U64_02340	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_02350	COG1335	isochorismatase
C2U64_02440	COG2814	Major facilitator Superfamily
C2U64_02445	COG0583	DNA-binding transcription factor activity
C2U64_02465	COG0667	Aldo Keto reductase
C2U64_02505	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2U64_02595	COG2814	Major facilitator Superfamily
C2U64_02660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U64_02685	COG0582	viral genome integration into host DNA
C2U64_02745	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2U64_02760	COG0697	spore germination
C2U64_02785	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2U64_02815	COG0427	acetyl-CoA hydrolase
C2U64_02825	COG2205	protein histidine kinase activity
C2U64_02830	COG0745	RESPONSE REGULATOR receiver
C2U64_02840	COG0659	secondary active sulfate transmembrane transporter activity
C2U64_02845	COG4221	oxidoreductase activity
C2U64_02855	COG0488	(ABC) transporter
C2U64_02940	COG0833	amino acid
C2U64_02985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U64_02990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2U64_03005	COG2226	methyltransferase
C2U64_03055	COG0070	glutamate synthase
C2U64_03055	COG0069	glutamate synthase activity
C2U64_03055	COG0067	glutamate synthase
C2U64_03060	COG0493	'glutamate synthase
C2U64_03070	COG1704	LemA family
C2U64_03075	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2U64_03085	COG4969	Belongs to the N-Me-Phe pilin family
C2U64_03095	COG3307	-O-antigen
C2U64_03120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U64_03135	COG0194	GDP metabolic process
C2U64_03185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2U64_03195	COG0335	large ribosomal subunit rRNA binding
C2U64_03205	COG5380	lipid catabolic process
C2U64_03210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2U64_03225	COG5006	permease, DMT superfamily
C2U64_03235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U64_03240	COG0277	FAD linked oxidase domain protein
C2U64_03250	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2U64_03255	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U64_03270	COG1289	transmembrane transporter activity
C2U64_03280	COG0628	permease
C2U64_03285	COG1192	Involved in chromosome partitioning
C2U64_03315	COG0833	amino acid
C2U64_03320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U64_03325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U64_03335	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_03375	COG0583	DNA-binding transcription factor activity
C2U64_03400	COG0752	glycyl-tRNA synthetase alpha subunit
C2U64_03425	COG0517	IMP dehydrogenase activity
C2U64_03430	COG1983	PspC domain protein
C2U64_03440	COG1960	acyl-CoA dehydrogenase activity
C2U64_03455	COG0408	coproporphyrinogen oxidase activity
C2U64_03475	COG0513	Belongs to the DEAD box helicase family
C2U64_03485	COG1127	ABC transporter
C2U64_03490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U64_03500	COG2854	intermembrane phospholipid transfer
C2U64_03510	COG0598	Magnesium transport protein CorA
C2U64_03520	COG0494	nUDIX hydrolase
C2U64_03525	COG1040	competence protein
C2U64_03530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2U64_03545	COG2937	Belongs to the GPAT DAPAT family
C2U64_03550	COG1946	Acyl-CoA thioesterase
C2U64_03555	COG1301	dicarboxylic acid transport
C2U64_03570	COG1959	2 iron, 2 sulfur cluster binding
C2U64_03575	COG1017	nitric oxide dioxygenase activity
C2U64_03575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U64_03585	COG0433	COG0433 Predicted ATPase
C2U64_03590	COG0626	cystathionine gamma-synthase activity
C2U64_03605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2U64_03610	COG0088	Forms part of the polypeptide exit tunnel
C2U64_03710	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U64_03720	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2U64_03745	COG1960	acyl-CoA dehydrogenase activity
C2U64_03750	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2U64_03780	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2U64_03785	COG0339	signal peptide processing
C2U64_03790	COG0557	exoribonuclease II activity
C2U64_03840	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2U64_03845	COG1295	ribonuclease BN
C2U64_03880	COG1702	phosphate starvation-inducible protein PhoH
C2U64_03890	COG0739	heme binding
C2U64_03890	COG1196	nuclear chromosome segregation
C2U64_03890	COG0741	lytic transglycosylase activity
C2U64_03920	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2U64_03925	COG1183	phosphatidylcholine synthase activity
C2U64_03970	COG1960	acyl-CoA dehydrogenase activity
C2U64_03975	COG1309	transcriptional regulator
C2U64_03990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2U64_03995	COG1960	acyl-CoA dehydrogenase activity
C2U64_04035	COG2969	positive regulation of protein catabolic process
C2U64_04040	COG0625	glutathione transferase activity
C2U64_04045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2U64_04050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2U64_04055	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U64_04060	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2U64_04065	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U64_04085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2U64_04095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U64_04100	COG1408	metallophosphoesterase
C2U64_04105	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2U64_04105	COG2885	chlorophyll binding
C2U64_04110	COG2199	diguanylate cyclase activity
C2U64_04165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U64_04165	COG3453	Protein conserved in bacteria
C2U64_04180	COG1607	acyl-coa hydrolase
C2U64_04215	COG2350	Protein conserved in bacteria
C2U64_04230	COG3781	membrane
C2U64_04240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2U64_04255	COG1862	Preprotein translocase
C2U64_04290	COG2205	protein histidine kinase activity
C2U64_04290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U64_04290	COG0784	Response regulator, receiver
C2U64_04290	COG2198	Histidine kinase
C2U64_04295	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C2U64_04310	COG0726	polysaccharide deacetylase
C2U64_04325	COG1216	Glycosyl transferase, family 2
C2U64_04375	COG0625	glutathione transferase activity
C2U64_04380	COG0583	DNA-binding transcription factor activity
C2U64_04385	COG1960	acyl-CoA dehydrogenase activity
C2U64_04390	COG1960	acyl-CoA dehydrogenase activity
C2U64_04400	COG2205	protein histidine kinase activity
C2U64_04405	COG0745	RESPONSE REGULATOR receiver
C2U64_04415	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2U64_04435	COG2096	Adenosyltransferase
C2U64_04440	COG4206	TonB-dependent receptor
C2U64_04450	COG0133	tryptophan synthase activity
C2U64_04485	COG0285	dihydrofolate synthase activity
C2U64_04505	COG0450	alkyl hydroperoxide reductase
C2U64_04520	COG0477	Major facilitator Superfamily
C2U64_04525	COG1272	protein, Hemolysin III
C2U64_04535	COG2153	protein acetylation
C2U64_04555	COG0183	Belongs to the thiolase family
C2U64_04560	COG2207	Transcriptional regulator
C2U64_04580	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U64_04600	COG0183	Belongs to the thiolase family
C2U64_04610	COG2885	chlorophyll binding
C2U64_04610	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2U64_04615	COG1690	Belongs to the RtcB family
C2U64_04620	COG0833	amino acid
C2U64_04630	COG2233	PERMEase
C2U64_04660	COG2094	Belongs to the DNA glycosylase MPG family
C2U64_04665	COG4772	TonB-dependent receptor
C2U64_04670	COG1902	pentaerythritol trinitrate reductase activity
C2U64_04675	COG0679	Auxin Efflux Carrier
C2U64_04685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U64_04690	COG0354	folic acid binding
C2U64_04710	COG2233	PERMEase
C2U64_04715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U64_04720	COG0251	oxidation-reduction process
C2U64_04725	COG1335	isochorismatase
C2U64_04730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U64_04735	COG0778	Nitroreductase
C2U64_04740	COG0596	Alpha beta hydrolase
C2U64_04745	COG3189	MarR family transcriptional regulator
C2U64_04750	COG2824	Alkylphosphonate utilization operon protein PhnA
C2U64_04755	COG3422	double-strand break repair
C2U64_04795	COG0840	transmembrane signaling receptor activity
C2U64_04815	COG5510	response to toxic substance
C2U64_04825	COG2832	Protein of unknown function (DUF454)
C2U64_04830	COG1376	ErfK ybiS ycfS ynhG family protein
C2U64_04870	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2U64_04880	COG1289	transmembrane transporter activity
C2U64_04885	COG2814	Major facilitator Superfamily
C2U64_04910	COG1115	amino acid carrier protein
C2U64_04915	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U64_04920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U64_04925	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C2U64_04930	COG3590	peptidase
C2U64_04955	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2U64_04965	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2U64_04970	COG1077	Cell shape determining protein MreB Mrl
C2U64_04975	COG1792	Involved in formation and maintenance of cell shape
C2U64_04980	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2U64_04985	COG0424	maF-like protein
C2U64_04990	COG1530	ribonuclease E activity
C2U64_05000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U64_05020	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U64_05045	COG2207	Transcriptional regulator
C2U64_05075	COG3046	protein related to deoxyribodipyrimidine photolyase
C2U64_05085	COG1113	amino acid transport
C2U64_05095	COG0142	geranyltranstransferase activity
C2U64_05100	COG2315	Protein conserved in bacteria
C2U64_05115	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U64_05140	COG2194	sulfuric ester hydrolase activity
C2U64_05145	COG0745	RESPONSE REGULATOR receiver
C2U64_05150	COG0642	Histidine kinase
C2U64_05165	COG0004	ammonium transporteR
C2U64_05170	COG0583	DNA-binding transcription factor activity
C2U64_05195	COG0525	valine-tRNA ligase activity
C2U64_05205	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_05215	COG0393	Putative heavy-metal-binding
C2U64_05220	COG0393	Putative heavy-metal-binding
C2U64_05225	COG1538	Outer membrane efflux protein
C2U64_05235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U64_05240	COG0671	phosphoesterase, PA-phosphatase related
C2U64_05265	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2U64_05280	COG1648	precorrin-2 dehydrogenase activity
C2U64_05280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U64_05285	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2U64_05305	COG0531	amino acid
C2U64_05320	COG0321	lipoyl(octanoyl) transferase activity
C2U64_05325	COG2921	Belongs to the UPF0250 family
C2U64_05370	COG2009	succinate dehydrogenase
C2U64_05375	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2U64_05380	COG1053	succinate dehydrogenase
C2U64_05385	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2U64_05410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U64_05430	COG2354	Protein conserved in bacteria
C2U64_05435	COG2321	neutral zinc metallopeptidase
C2U64_05455	COG2843	Capsule synthesis protein
C2U64_05480	COG0589	response to stress
C2U64_05490	COG0251	oxidation-reduction process
C2U64_05495	COG1309	transcriptional regulator
C2U64_05510	COG0505	Belongs to the CarA family
C2U64_05545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U64_05550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2U64_05595	COG2264	protein methyltransferase activity
C2U64_05605	COG0477	Major facilitator Superfamily
C2U64_05610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2U64_05630	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2U64_05955	COG0582	viral genome integration into host DNA
C2U64_05965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U64_05970	COG0584	glycerophosphoryl diester phosphodiesterase
C2U64_05990	COG0741	lytic transglycosylase activity
C2U64_06015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U64_06060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U64_06065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U64_06070	COG0778	Nitroreductase
C2U64_06085	COG1929	Belongs to the glycerate kinase type-1 family
C2U64_06090	COG0243	molybdopterin cofactor binding
C2U64_06095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2U64_06130	COG1115	amino acid carrier protein
C2U64_06135	COG1113	amino acid transport
C2U64_06145	COG0019	diaminopimelate decarboxylase activity
C2U64_06155	COG1280	lysine exporter protein (LysE YggA)
C2U64_06160	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2U64_06190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U64_06220	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U64_06225	COG1136	(ABC) transporter
C2U64_06230	COG2333	competence protein COMEC
C2U64_06230	COG0658	competence protein
C2U64_06240	COG0616	signal peptide processing
C2U64_06240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U64_06245	COG0596	Alpha beta hydrolase
C2U64_06250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2U64_06260	COG0628	permease
C2U64_06300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U64_06320	COG0823	Involved in the tonB-independent uptake of proteins
C2U64_06340	COG0824	Thioesterase
C2U64_06345	COG1473	amidohydrolase
C2U64_06365	COG0047	phosphoribosylformylglycinamidine synthase activity
C2U64_06365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2U64_06370	COG2814	Major facilitator Superfamily
C2U64_06375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2U64_06380	COG1024	Enoyl-CoA hydratase
C2U64_06385	COG1056	cytidyltransferase-related domain
C2U64_06385	COG1051	belongs to the nudix hydrolase family
C2U64_06400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2U64_06415	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2U64_06430	COG4625	pathogenesis
C2U64_06435	COG0583	DNA-binding transcription factor activity
C2U64_06440	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2U64_06445	COG4208	sulfate ABC transporter
C2U64_06450	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2U64_06460	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2U64_06465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U64_06470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2U64_06490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U64_06500	COG0481	GTPase activity
C2U64_06505	COG0681	Belongs to the peptidase S26 family
C2U64_06515	COG0571	ribonuclease III activity
C2U64_06520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2U64_06535	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2U64_06545	COG4221	oxidoreductase activity
C2U64_06595	COG0556	nucleotide-excision repair
C2U64_06605	COG2962	Rard protein
C2U64_06650	COG2070	2-Nitropropane dioxygenase
C2U64_06665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2U64_06680	COG1215	transferase activity, transferring glycosyl groups
C2U64_06695	COG0415	Belongs to the DNA photolyase family
C2U64_06705	COG1252	NADH dehydrogenase
C2U64_06710	COG1686	Belongs to the peptidase S11 family
C2U64_06725	COG1187	pseudouridine synthase activity
C2U64_06740	COG0477	Major facilitator Superfamily
C2U64_06745	COG0583	DNA-binding transcription factor activity
C2U64_06760	COG0612	Peptidase, M16
C2U64_06785	COG0352	thiamine-phosphate diphosphorylase activity
C2U64_06820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U64_06835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U64_06840	COG0076	glutamate decarboxylase activity
C2U64_06850	COG1522	sequence-specific DNA binding
C2U64_06855	COG3961	Belongs to the TPP enzyme family
C2U64_06860	COG1113	amino acid transport
C2U64_06865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2U64_06870	COG0573	inorganic phosphate transmembrane transporter activity
C2U64_06880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2U64_06885	COG0616	signal peptide processing
C2U64_06920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2U64_06925	COG1686	Belongs to the peptidase S11 family
C2U64_06950	COG0583	DNA-binding transcription factor activity
C2U64_06955	COG1067	ATP-dependent peptidase activity
C2U64_06995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2U64_07000	COG1966	Carbon starvation protein
C2U64_07005	COG2879	small protein
C2U64_07055	COG1741	Belongs to the pirin family
C2U64_07070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U64_07075	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U64_07080	COG4605	iron ion homeostasis
C2U64_07085	COG4604	ABC transporter, ATP-binding protein
C2U64_07090	COG4607	ABC-type enterochelin transport system periplasmic component
C2U64_07095	COG4774	siderophore transport
C2U64_07105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U64_07110	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2U64_07115	COG3433	isochorismatase activity
C2U64_07115	COG1535	isochorismatase
C2U64_07130	COG1132	(ABC) transporter
C2U64_07140	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C2U64_07150	COG1169	isochorismate synthase
C2U64_07170	COG3739	integral membrane protein
C2U64_07190	COG0302	gtp cyclohydrolase
C2U64_07200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2U64_07210	COG2840	Smr protein MutS2
C2U64_07245	COG0512	Glutamine amidotransferase of anthranilate synthase
C2U64_07370	COG5410	chromosome segregation
C2U64_07480	COG0582	viral genome integration into host DNA
C2U64_07490	COG3104	oligopeptide transport
C2U64_07505	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C2U64_07540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2U64_07545	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2U64_07550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U64_07570	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U64_07575	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2U64_07580	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C2U64_07595	COG1960	acyl-CoA dehydrogenase activity
C2U64_07600	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2U64_07605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U64_07615	COG2223	nitrite transmembrane transporter activity
C2U64_07625	COG0024	Methionine aminopeptidase
C2U64_07630	COG0052	Belongs to the universal ribosomal protein uS2 family
C2U64_07670	COG2951	lytic endotransglycosylase activity
C2U64_07675	COG0772	Belongs to the SEDS family
C2U64_07690	COG0842	Transport permease protein
C2U64_07695	COG1131	(ABC) transporter
C2U64_07730	COG1538	Outer membrane efflux protein
C2U64_07740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U64_07750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U64_07755	COG4215	(ABC) transporter
C2U64_07760	COG4160	amino acid transport
C2U64_07765	COG4598	ABC transporter
C2U64_07775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U64_07785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U64_07790	COG0384	phenazine biosynthesis protein PhzF
C2U64_07800	COG1720	tRNA m6t6A37 methyltransferase activity
C2U64_07820	COG0745	RESPONSE REGULATOR receiver
C2U64_07825	COG0642	Histidine kinase
C2U64_07835	COG0494	nUDIX hydrolase
C2U64_07845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U64_07850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2U64_07855	COG3139	Protein of unknown function (DUF1315)
C2U64_07860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U64_07870	COG1301	dicarboxylic acid transport
C2U64_07875	COG1960	acyl-CoA dehydrogenase activity
C2U64_07890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2U64_07900	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U64_07905	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U64_07925	COG1690	Belongs to the RtcB family
C2U64_07930	COG1234	tRNA 3'-trailer cleavage
C2U64_07935	COG4650	regulator
C2U64_07965	COG2363	Small membrane protein
C2U64_07985	COG0513	Belongs to the DEAD box helicase family
C2U64_07995	COG0778	Nitroreductase
C2U64_08025	COG1286	toxin biosynthetic process
C2U64_08050	COG4783	chaperone-mediated protein folding
C2U64_08055	COG1610	YqeY-like protein
C2U64_08060	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2U64_08110	COG1278	Cold shock
C2U64_08125	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2U64_08130	COG0786	glutamate:sodium symporter activity
C2U64_08135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U64_08135	COG0475	glutathione-regulated potassium exporter activity
C2U64_08140	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_08190	COG1309	transcriptional regulator
C2U64_08200	COG2985	domain, Protein
C2U64_08215	COG2995	paraquat-inducible protein a
C2U64_08220	COG3008	intermembrane lipid transfer
C2U64_08220	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U64_08230	COG2351	hydroxyisourate hydrolase activity
C2U64_08270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U64_08280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U64_08285	COG0642	Histidine kinase
C2U64_08290	COG0745	RESPONSE REGULATOR receiver
C2U64_08305	COG1794	racemase activity, acting on amino acids and derivatives
C2U64_08335	COG1301	dicarboxylic acid transport
C2U64_08345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U64_08350	COG2011	ABC-type metal ion transport system permease component
C2U64_08355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U64_08365	COG0151	Belongs to the GarS family
C2U64_08375	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C2U64_08405	COG2308	Evidence 4 Homologs of previously reported genes of
C2U64_08415	COG1305	Transglutaminase-like
C2U64_08425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U64_08430	COG0305	Participates in initiation and elongation during chromosome replication
C2U64_08455	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2U64_08460	COG1845	cytochrome c oxidase, subunit III
C2U64_08465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U64_08495	COG3328	transposase activity
C2U64_08500	COG0726	polysaccharide deacetylase
C2U64_08500	COG1649	PFAM Uncharacterised BCR, COG1649
C2U64_08505	COG1215	transferase activity, transferring glycosyl groups
C2U64_08510	COG3658	cytochrome
C2U64_08520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U64_08535	COG0583	DNA-binding transcription factor activity
C2U64_08550	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U64_08555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U64_08560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U64_08575	COG1960	acyl-CoA dehydrogenase activity
C2U64_08580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U64_08595	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2U64_08605	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C2U64_08610	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C2U64_08620	COG2205	protein histidine kinase activity
C2U64_08625	COG0745	RESPONSE REGULATOR receiver
C2U64_08630	COG0174	glutamine synthetase
C2U64_08645	COG0477	Major facilitator Superfamily
C2U64_08650	COG0729	surface antigen
C2U64_08685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U64_08690	COG2814	Major facilitator Superfamily
C2U64_08745	COG2369	cell adhesion
C2U64_08750	COG4383	Mu-like prophage protein gp29
C2U64_08760	COG4373	Mu-like prophage FluMu protein gp28
C2U64_08825	COG3267	Type II secretory pathway component ExeA
C2U64_08825	COG3409	Peptidoglycan-binding domain 1 protein
C2U64_08850	COG0776	regulation of translation
C2U64_08900	COG0583	DNA-binding transcription factor activity
C2U64_08915	COG1187	pseudouridine synthase activity
C2U64_08935	COG0802	atpase or kinase
C2U64_08940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2U64_08950	COG1923	regulation of RNA biosynthetic process
C2U64_08955	COG0697	spore germination
C2U64_08980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U64_08985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U64_08985	COG0519	Catalyzes the synthesis of GMP from XMP
C2U64_08995	COG4302	ethanolamine ammonia-lyase activity
C2U64_09000	COG4303	Ethanolamine ammonia lyase large subunit
C2U64_09005	COG0531	amino acid
C2U64_09025	COG1454	alcohol dehydrogenase
C2U64_09030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U64_09055	COG0308	aminopeptidase N
C2U64_09095	COG1605	Chorismate mutase
C2U64_09120	COG2826	transposase and inactivated derivatives, IS30 family
C2U64_09155	COG3772	lysozyme
C2U64_09165	COG1733	regulation of RNA biosynthetic process
C2U64_09190	COG0583	DNA-binding transcription factor activity
C2U64_09230	COG0488	(ABC) transporter
C2U64_09235	COG0589	response to stress
C2U64_09255	COG3135	benzoate transporter
C2U64_09260	COG1522	sequence-specific DNA binding
C2U64_09275	COG0583	DNA-binding transcription factor activity
C2U64_09285	COG0183	Belongs to the thiolase family
C2U64_09290	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_09325	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2U64_09335	COG0824	Thioesterase
C2U64_09340	COG1454	alcohol dehydrogenase
C2U64_09355	COG1335	isochorismatase
C2U64_09375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2U64_09405	COG0069	glutamate synthase activity
C2U64_09430	COG2814	Major facilitator Superfamily
C2U64_09445	COG0511	ligase activity, forming carbon-carbon bonds
C2U64_09470	COG4264	IucA IucC family
C2U64_09480	COG4264	IucA IucC family
C2U64_09485	COG2423	ornithine cyclodeaminase activity
C2U64_09490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2U64_09495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U64_09495	COG1116	anion transmembrane transporter activity
C2U64_09510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U64_09510	COG2146	nitrite reductase [NAD(P)H] activity
C2U64_09515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U64_09520	COG0243	molybdopterin cofactor binding
C2U64_09530	COG0243	molybdopterin cofactor binding
C2U64_09535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2U64_09550	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U64_09550	COG0315	cyclic pyranopterin monophosphate synthase activity
C2U64_09555	COG0303	'Molybdopterin
C2U64_09565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U64_09570	COG0697	spore germination
C2U64_09595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U64_09665	COG2204	response regulator
C2U64_09670	COG3852	Histidine kinase
C2U64_09695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2U64_09700	COG0575	Belongs to the CDS family
C2U64_09735	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U64_09750	COG2137	regulation of response to DNA damage stimulus
C2U64_09760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2U64_09765	COG1011	Hydrolase
C2U64_09780	COG1522	sequence-specific DNA binding
C2U64_09790	COG1113	amino acid transport
C2U64_09795	COG0657	acetylesterase activity
C2U64_09810	COG0659	secondary active sulfate transmembrane transporter activity
C2U64_09845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U64_09845	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2U64_09845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U64_09850	COG1105	Belongs to the carbohydrate kinase PfkB family
C2U64_09855	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U64_09855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2U64_09875	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C2U64_09885	COG0024	Methionine aminopeptidase
C2U64_09890	COG0583	DNA-binding transcription factor activity
C2U64_09900	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2U64_09905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U64_09910	COG0517	IMP dehydrogenase activity
C2U64_09910	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2U64_09935	COG0552	protein localization to endoplasmic reticulum
C2U64_09960	COG4890	Cyd operon protein YbgT
C2U64_09965	COG1294	oxidase, subunit
C2U64_09980	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2U64_09990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U64_10005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U64_10010	COG0569	domain protein
C2U64_10015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U64_10045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2U64_10050	COG0542	response to heat
C2U64_10060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U64_10075	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U64_10075	COG1902	pentaerythritol trinitrate reductase activity
C2U64_10115	COG0148	phosphopyruvate hydratase activity
C2U64_10120	COG2323	membrane
C2U64_10130	COG4773	Receptor
C2U64_10135	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2U64_10145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2U64_10150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U64_10155	COG0183	Belongs to the thiolase family
C2U64_10160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2U64_10165	COG0596	Alpha beta hydrolase
C2U64_10170	COG2271	Major facilitator Superfamily
C2U64_10175	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U64_10180	COG3485	protocatechuate 3,4-dioxygenase
C2U64_10185	COG3485	protocatechuate 3,4-dioxygenase
C2U64_10190	COG0710	3-dehydroquinate dehydratase activity
C2U64_10195	COG3420	alginic acid biosynthetic process
C2U64_10200	COG3659	wide pore channel activity
C2U64_10205	COG4993	Dehydrogenase
C2U64_10215	COG2391	methyltransferase activity
C2U64_10230	COG1414	Transcriptional regulator
C2U64_10235	COG0583	DNA-binding transcription factor activity
C2U64_10240	COG1960	acyl-CoA dehydrogenase activity
C2U64_10265	COG2814	Major facilitator Superfamily
C2U64_10275	COG0154	amidase activity
C2U64_10295	COG4638	Rieske (2fe-2S)
C2U64_10305	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_10315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U64_10325	COG3733	amine oxidase
C2U64_10335	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_10340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U64_10345	COG0183	Belongs to the thiolase family
C2U64_10350	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U64_10355	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2U64_10365	COG4829	muconolactone delta-isomerase
C2U64_10370	COG4948	Mandelate Racemase Muconate Lactonizing
C2U64_10375	COG0583	DNA-binding transcription factor activity
C2U64_10385	COG2186	Transcriptional regulator
C2U64_10405	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_10410	COG2351	hydroxyisourate hydrolase activity
C2U64_10415	COG2233	PERMEase
C2U64_10425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U64_10430	COG2186	Transcriptional regulator
C2U64_10445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U64_10455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U64_10475	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U64_10475	COG1902	pentaerythritol trinitrate reductase activity
C2U64_10515	COG1960	acyl-CoA dehydrogenase activity
C2U64_10525	COG0318	PFAM AMP-dependent synthetase and ligase
C2U64_10540	COG1309	transcriptional regulator
C2U64_10570	COG0018	arginyl-trna synthetase
C2U64_10600	COG0583	DNA-binding transcription factor activity
C2U64_10625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U64_10630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U64_10645	COG2831	hemolysin activation secretion protein
C2U64_10720	COG1120	ATPase activity
C2U64_10730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U64_10780	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2U64_10815	COG4628	conserved protein (DUF2132)
C2U64_10830	COG3539	Fimbrial protein
C2U64_10855	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C2U64_10865	COG0753	catalase activity
C2U64_10885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U64_10895	COG2205	protein histidine kinase activity
C2U64_10900	COG0745	RESPONSE REGULATOR receiver
C2U64_10905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U64_10910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U64_10965	COG3433	isochorismatase activity
C2U64_10965	COG1535	isochorismatase
C2U64_10970	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_10975	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2U64_10980	COG4149	molybdate abc transporter
C2U64_10985	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2U64_10995	COG4638	Rieske (2fe-2S)
C2U64_11000	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2U64_11005	COG0543	2 iron, 2 sulfur cluster binding
C2U64_11005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U64_11020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U64_11030	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_11035	COG0412	Dienelactone hydrolase
C2U64_11050	COG2207	Transcriptional regulator
C2U64_11055	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_11060	COG2610	gluconate transmembrane transporter activity
C2U64_11100	COG0583	DNA-binding transcription factor activity
C2U64_11115	COG2031	fatty acid transporter
C2U64_11120	COG0183	Belongs to the thiolase family
C2U64_11125	COG0583	DNA-binding transcription factor activity
C2U64_11130	COG2826	transposase and inactivated derivatives, IS30 family
C2U64_11135	COG0583	DNA-binding transcription factor activity
C2U64_11150	COG1027	Aspartate ammonia-lyase
C2U64_11160	COG0477	Major facilitator Superfamily
C2U64_11170	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U64_11175	COG1733	regulation of RNA biosynthetic process
C2U64_11180	COG3708	Transcriptional regulator
C2U64_11180	COG2207	Transcriptional regulator
C2U64_11195	COG0730	response to heat
C2U64_11215	COG3781	membrane
C2U64_11220	COG1063	alcohol dehydrogenase
C2U64_11230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U64_11235	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U64_11240	COG0022	dehydrogenase e1 component
C2U64_11245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2U64_11250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2U64_11265	COG3706	GGDEF domain
C2U64_11285	COG0133	tryptophan synthase activity
C2U64_11295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U64_11325	COG0583	DNA-binding transcription factor activity
C2U64_11330	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U64_11340	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2U64_11400	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U64_11405	COG4773	Receptor
C2U64_11430	COG0730	response to heat
C2U64_11435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U64_11455	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C2U64_11485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U64_11500	COG1960	acyl-CoA dehydrogenase activity
C2U64_11505	COG1960	acyl-CoA dehydrogenase activity
C2U64_11510	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U64_11515	COG2207	Transcriptional regulator
C2U64_11520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U64_11525	COG0776	regulation of translation
C2U64_11550	COG0822	iron-sulfur transferase activity
C2U64_11555	COG0316	Belongs to the HesB IscA family
C2U64_11585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2U64_11605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U64_11610	COG0702	epimerase
C2U64_11650	COG0601	transmembrane transport
C2U64_11655	COG0339	signal peptide processing
C2U64_11660	COG4166	transmembrane transport
C2U64_11705	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2U64_11815	COG3328	transposase activity
C2U64_11825	COG3728	DNA packaging
C2U64_11825	COG5484	DNA packaging
C2U64_11910	COG5377	YqaJ viral recombinase family
C2U64_11920	COG0210	DNA helicase
C2U64_11950	COG0582	viral genome integration into host DNA
C2U64_11955	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2U64_11970	COG3328	transposase activity
C2U64_11975	COG2431	L-lysine efflux transmembrane transporter activity
C2U64_11990	COG0776	regulation of translation
C2U64_12010	COG0590	tRNA wobble adenosine to inosine editing
C2U64_12055	COG0084	hydrolase, TatD family'
C2U64_12075	COG1663	tetraacyldisaccharide 4'-kinase activity
C2U64_12080	COG1132	(ABC) transporter
C2U64_12090	COG0811	peptide transport
C2U64_12095	COG1475	DNA binding
C2U64_12100	COG1192	Involved in chromosome partitioning
C2U64_12110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2U64_12115	COG3178	'Phosphotransferase
C2U64_12125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U64_12150	COG0424	maF-like protein
C2U64_12155	COG2850	peptidyl-arginine hydroxylation
C2U64_12165	COG0640	Transcriptional regulator
C2U64_12175	COG3619	membrane
C2U64_12180	COG3122	Protein conserved in bacteria
C2U64_12185	COG1132	(ABC) transporter
C2U64_12205	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2U64_12210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U64_12220	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U64_12220	COG0506	proline dehydrogenase activity
C2U64_12220	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U64_12225	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2U64_12240	COG3698	Phosphodiester glycosidase
C2U64_12250	COG2353	YceI-like domain
C2U64_12260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2U64_12305	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2U64_12305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2U64_12335	COG3539	Fimbrial protein
C2U64_12370	COG0583	DNA-binding transcription factor activity
C2U64_12375	COG0697	spore germination
C2U64_12385	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2U64_12395	COG0583	DNA-binding transcription factor activity
C2U64_12410	COG1309	transcriptional regulator
C2U64_12425	COG1522	sequence-specific DNA binding
C2U64_12435	COG1126	abc transporter atp-binding protein
C2U64_12440	COG0765	amino acid transport
C2U64_12445	COG0765	amino acid transport
C2U64_12475	COG1464	Belongs to the NlpA lipoprotein family
C2U64_12485	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U64_12490	COG2011	ABC-type metal ion transport system permease component
C2U64_12495	COG0012	GTP binding
C2U64_12520	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2U64_12555	COG2207	Transcriptional regulator
C2U64_12555	COG1917	Cupin 2, conserved barrel domain protein
C2U64_12560	COG0386	Belongs to the glutathione peroxidase family
C2U64_12570	COG0436	Aminotransferase
C2U64_12575	COG1301	dicarboxylic acid transport
C2U64_12610	COG3634	alkyl hydroperoxide reductase activity
C2U64_12625	COG0583	DNA-binding transcription factor activity
C2U64_12630	COG0431	NADPH-dependent FMN reductase
C2U64_12635	COG0798	PFAM Bile acid sodium symporter
C2U64_12645	COG0640	Transcriptional regulator
C2U64_12660	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2U64_12670	COG0583	DNA-binding transcription factor activity
C2U64_12680	COG1953	Uracil, thiamine, allantoin
C2U64_12690	COG2175	clavaminate synthase activity
C2U64_12695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U64_12700	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2U64_12705	COG4521	taurine ABC transporter
C2U64_12715	COG0477	Major facilitator Superfamily
C2U64_12740	COG1271	oxidase subunit
C2U64_12745	COG1294	oxidase, subunit
C2U64_12755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U64_12775	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2U64_12795	COG3052	prosthetic group binding
C2U64_12800	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C2U64_12825	COG1346	cytolysis
C2U64_12835	COG0583	DNA-binding transcription factor activity
C2U64_12840	COG0625	glutathione transferase activity
C2U64_12845	COG0625	glutathione transferase activity
C2U64_12865	COG0583	DNA-binding transcription factor activity
C2U64_12880	COG1045	serine acetyltransferase
C2U64_12890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U64_12895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2U64_12900	COG1280	lysine exporter protein (LysE YggA)
C2U64_12915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U64_12920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U64_12930	COG0765	amino acid transport
C2U64_12935	COG0765	amino acid transport
C2U64_12955	COG0784	Response regulator, receiver
C2U64_12955	COG2205	protein histidine kinase activity
C2U64_12975	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U64_12995	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_13045	COG0583	DNA-binding transcription factor activity
C2U64_13060	COG2814	Major facilitator Superfamily
C2U64_13075	COG0318	PFAM AMP-dependent synthetase and ligase
C2U64_13080	COG1309	transcriptional regulator
C2U64_13085	COG1960	acyl-CoA dehydrogenase activity
C2U64_13090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2U64_13095	COG1024	Enoyl-CoA hydratase
C2U64_13110	COG0583	DNA-binding transcription factor activity
C2U64_13125	COG1960	acyl-CoA dehydrogenase activity
C2U64_13135	COG2814	Major facilitator Superfamily
C2U64_13145	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U64_13150	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2U64_13155	COG2814	Major facilitator Superfamily
C2U64_13160	COG1960	acyl-CoA dehydrogenase activity
C2U64_13165	COG1024	Enoyl-CoA hydratase
C2U64_13170	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_13175	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U64_13180	COG0183	Belongs to the thiolase family
C2U64_13190	COG2814	Major facilitator Superfamily
C2U64_13200	COG1024	Enoyl-CoA hydratase
C2U64_13215	COG1960	acyl-CoA dehydrogenase activity
C2U64_13220	COG2814	Major facilitator Superfamily
C2U64_13225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U64_13230	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2U64_13245	COG3842	ATPase activity
C2U64_13250	COG1840	ABC-type Fe3 transport system, periplasmic component
C2U64_13265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U64_13270	COG1414	Transcriptional regulator
C2U64_13280	COG0583	DNA-binding transcription factor activity
C2U64_13310	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_13315	COG0583	DNA-binding transcription factor activity
C2U64_13320	COG2050	protein possibly involved in aromatic compounds catabolism
C2U64_13330	COG3327	negative regulation of DNA-templated transcription, initiation
C2U64_13335	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C2U64_13340	COG0183	Belongs to the thiolase family
C2U64_13345	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U64_13350	COG1024	Enoyl-CoA hydratase
C2U64_13355	COG1024	Enoyl-CoA hydratase
C2U64_13360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U64_13365	COG2151	metal-sulfur cluster biosynthetic enzyme
C2U64_13370	COG3396	Phenylacetate-CoA oxygenase
C2U64_13375	COG3460	Phenylacetate-CoA oxygenase
C2U64_13380	COG3396	Phenylacetate-CoA oxygenase
C2U64_13385	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_13385	COG2030	dehydratase
C2U64_13390	COG1760	l-serine dehydratase
C2U64_13410	COG0789	Transcriptional regulator
C2U64_13420	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2U64_13425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U64_13440	COG2807	transmembrane transport
C2U64_13445	COG0590	tRNA wobble adenosine to inosine editing
C2U64_13450	COG0666	response to abiotic stimulus
C2U64_13455	COG0583	DNA-binding transcription factor activity
C2U64_13475	COG0439	Biotin carboxylase
C2U64_13490	COG1063	alcohol dehydrogenase
C2U64_13495	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U64_13540	COG2831	hemolysin activation secretion protein
C2U64_13545	COG0038	chloride channel
C2U64_13550	COG4770	biotin carboxylase activity
C2U64_13570	COG1914	H( )-stimulated, divalent metal cation uptake system
C2U64_13575	COG0583	DNA-binding transcription factor activity
C2U64_13585	COG1595	DNA-templated transcription, initiation
C2U64_13595	COG3220	belongs to the UPF0276 family
C2U64_13655	COG0702	epimerase
C2U64_13660	COG1733	regulation of RNA biosynthetic process
C2U64_13680	COG1051	belongs to the nudix hydrolase family
C2U64_13690	COG1595	DNA-templated transcription, initiation
C2U64_13695	COG3712	iron ion homeostasis
C2U64_13735	COG3038	cytochrome b561
C2U64_13740	COG0753	catalase activity
C2U64_13745	COG1733	regulation of RNA biosynthetic process
C2U64_13770	COG1522	sequence-specific DNA binding
C2U64_13775	COG0531	amino acid
C2U64_13780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2U64_13795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U64_13810	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C2U64_13820	COG4122	O-methyltransferase activity
C2U64_13850	COG1538	Outer membrane efflux protein
C2U64_13855	COG1137	ATPase activity
C2U64_13860	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2U64_13870	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2U64_14005	COG5410	chromosome segregation
C2U64_14160	COG1733	regulation of RNA biosynthetic process
C2U64_14165	COG2814	Major facilitator Superfamily
C2U64_14175	COG0668	transmembrane transport
C2U64_14240	COG2226	methyltransferase
C2U64_14265	COG1278	Cold shock
C2U64_14270	COG1560	Kdo2-lipid A biosynthetic process
C2U64_14275	COG1280	lysine exporter protein (LysE YggA)
C2U64_14315	COG1570	exodeoxyribonuclease VII activity
C2U64_14400	COG2871	sodium ion transport
C2U64_14410	COG0583	DNA-binding transcription factor activity
C2U64_14420	COG4638	Rieske (2fe-2S)
C2U64_14425	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2U64_14430	COG0633	Ferredoxin
C2U64_14430	COG0543	2 iron, 2 sulfur cluster binding
C2U64_14435	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_14440	COG3135	benzoate transporter
C2U64_14445	COG2814	Major facilitator Superfamily
C2U64_14460	COG1643	Atp-dependent helicase
C2U64_14465	COG0450	alkyl hydroperoxide reductase
C2U64_14485	COG3634	alkyl hydroperoxide reductase activity
C2U64_14505	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2U64_14510	COG0625	glutathione transferase activity
C2U64_14520	COG2885	chlorophyll binding
C2U64_14555	COG0542	response to heat
C2U64_14570	COG1765	OsmC-like protein
C2U64_14585	COG0667	Aldo Keto reductase
C2U64_14600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C2U64_14610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U64_14620	COG0582	viral genome integration into host DNA
C2U64_14640	COG3293	Transposase
C2U64_14645	COG1063	alcohol dehydrogenase
C2U64_14685	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C2U64_14690	COG3421	Type III restriction
C2U64_14725	COG1196	nuclear chromosome segregation
C2U64_14725	COG0739	heme binding
C2U64_14725	COG0741	lytic transglycosylase activity
C2U64_14740	COG1598	PFAM Uncharacterised protein family UPF0150
C2U64_14930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2U64_14940	COG3038	cytochrome b561
C2U64_14945	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U64_14950	COG2252	PERMEase
C2U64_14960	COG1741	Belongs to the pirin family
C2U64_14965	COG1309	transcriptional regulator
C2U64_14980	COG2072	flavoprotein involved in K transport
C2U64_14985	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C2U64_14990	COG0583	DNA-binding transcription factor activity
C2U64_15000	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2U64_15035	COG1944	ATP diphosphatase activity
C2U64_15055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U64_15070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U64_15090	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C2U64_15095	COG2826	transposase and inactivated derivatives, IS30 family
C2U64_15110	COG2814	Major facilitator Superfamily
C2U64_15115	COG1024	Enoyl-CoA hydratase
C2U64_15130	COG1960	acyl-CoA dehydrogenase activity
C2U64_15155	COG2186	Transcriptional regulator
C2U64_15160	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_15170	COG4948	Mandelate Racemase Muconate Lactonizing
C2U64_15175	COG2271	Major facilitator Superfamily
C2U64_15180	COG2721	sulfolactate sulfo-lyase activity
C2U64_15185	COG0697	spore germination
C2U64_15205	COG1113	amino acid transport
C2U64_15225	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_15245	COG0531	amino acid
C2U64_15255	COG1113	amino acid transport
C2U64_15290	COG2801	Transposase and inactivated derivatives
C2U64_15300	COG4269	membrane
C2U64_15320	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U64_15320	COG1902	pentaerythritol trinitrate reductase activity
C2U64_15345	COG3328	transposase activity
C2U64_15360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U64_15385	COG4172	Belongs to the ABC transporter superfamily
C2U64_15390	COG4239	(ABC) transporter, permease
C2U64_15395	COG4174	ABC transporter (Permease)
C2U64_15400	COG4166	transmembrane transport
C2U64_15405	COG0741	lytic transglycosylase activity
C2U64_15405	COG1388	LysM domain
C2U64_15410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U64_15450	COG0583	DNA-binding transcription factor activity
C2U64_15455	COG1279	arginine transmembrane transporter activity
C2U64_15475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U64_15480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U64_15485	COG0006	proline dipeptidase activity
C2U64_15525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2U64_15540	COG3384	dioxygenase
C2U64_15550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U64_15555	COG2878	Part of a membrane complex involved in electron transport
C2U64_15560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2U64_15585	COG0768	penicillin binding
C2U64_15590	COG0742	ribosomal rna small subunit methyltransferase
C2U64_15605	COG0830	nickel cation binding
C2U64_15615	COG0804	urea catabolic process
C2U64_15640	COG3015	lipoprotein NlpE involved in copper resistance
C2U64_15655	COG1253	flavin adenine dinucleotide binding
C2U64_15660	COG2851	Citrate transporter
C2U64_15710	COG1773	rubredoxin
C2U64_15715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U64_15720	COG2267	carboxylic ester hydrolase activity
C2U64_15725	COG0583	DNA-binding transcription factor activity
C2U64_15755	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2U64_15760	COG4181	ATPase activity
C2U64_15805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U64_15825	COG0306	phosphate transporter
C2U64_15840	COG3958	Transketolase
C2U64_15845	COG3959	Transketolase, thiamine diphosphate binding domain
C2U64_15850	COG2271	Major facilitator Superfamily
C2U64_15855	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_15860	COG0583	DNA-binding transcription factor activity
C2U64_15880	COG2223	nitrite transmembrane transporter activity
C2U64_15885	COG0662	Cupin 2, conserved barrel domain protein
C2U64_15885	COG2207	Transcriptional regulator
C2U64_15890	COG2066	Belongs to the glutaminase family
C2U64_15895	COG0242	peptide deformylase activity
C2U64_15900	COG0477	Major facilitator Superfamily
C2U64_15910	COG0028	Belongs to the TPP enzyme family
C2U64_15925	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_15930	COG2267	carboxylic ester hydrolase activity
C2U64_15940	COG2271	Major facilitator Superfamily
C2U64_15945	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U64_15955	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_15975	COG1414	Transcriptional regulator
C2U64_15990	COG1024	Enoyl-CoA hydratase
C2U64_16000	COG1215	transferase activity, transferring glycosyl groups
C2U64_16005	COG1649	PFAM Uncharacterised BCR, COG1649
C2U64_16005	COG0726	polysaccharide deacetylase
C2U64_16015	COG4681	YaeQ
C2U64_16025	COG0523	cobalamin synthesis protein
C2U64_16035	COG1607	acyl-coa hydrolase
C2U64_16045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U64_16050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U64_16055	COG1309	transcriptional regulator
C2U64_16080	COG2040	homocysteine
C2U64_16085	COG0531	amino acid
C2U64_16110	COG2826	transposase and inactivated derivatives, IS30 family
C2U64_16140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U64_16145	COG0477	Major facilitator Superfamily
C2U64_16175	COG2826	transposase and inactivated derivatives, IS30 family
C2U64_16205	COG1401	restriction endodeoxyribonuclease activity
C2U64_16225	COG0405	Gamma-glutamyltransferase
C2U64_16230	COG2814	Major facilitator Superfamily
C2U64_16240	COG2050	protein possibly involved in aromatic compounds catabolism
C2U64_16255	COG1090	epimerase
C2U64_16275	COG0420	3'-5' exonuclease activity
C2U64_16300	COG0735	belongs to the Fur family
C2U64_16305	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U64_16310	COG2914	Belongs to the UPF0125 (RnfH) family
C2U64_16330	COG0121	glutamine amidotransferase
C2U64_16345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U64_16355	COG0210	DNA helicase
C2U64_16360	COG2885	chlorophyll binding
C2U64_16365	COG0204	Acyl-transferase
C2U64_16380	COG2894	cell division
C2U64_16395	COG1280	lysine exporter protein (LysE YggA)
C2U64_16400	COG1674	ftsk spoiiie
C2U64_16405	COG0492	ferredoxin-NADP+ reductase activity
C2U64_16410	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2U64_16420	COG0456	acetyltransferase
C2U64_16435	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U64_16440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2U64_16450	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2U64_16475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2U64_16475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U64_16495	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_16500	COG4638	Rieske (2fe-2S)
C2U64_16515	COG0473	3-isopropylmalate dehydrogenase activity
C2U64_16520	COG0583	DNA-binding transcription factor activity
C2U64_16540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U64_16575	COG0358	DNA primase activity
C2U64_16590	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C2U64_16620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U64_16650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U64_16660	COG0351	phosphomethylpyrimidine kinase
C2U64_16660	COG0352	thiamine-phosphate diphosphorylase activity
C2U64_16660	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2U64_16665	COG1652	LysM domain
C2U64_16675	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_16690	COG1399	metal-binding, possibly nucleic acid-binding protein
C2U64_16695	COG3101	peptidyl-lysine hydroxylation
C2U64_16700	COG0009	L-threonylcarbamoyladenylate synthase
C2U64_16705	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C2U64_16710	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2U64_16725	COG4106	trans-aconitate 2-methyltransferase activity
C2U64_16740	COG2226	methyltransferase
C2U64_16740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U64_16740	COG0596	Alpha beta hydrolase
C2U64_16750	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C2U64_16755	COG2223	nitrite transmembrane transporter activity
C2U64_16775	COG1196	nuclear chromosome segregation
C2U64_16785	COG0730	response to heat
C2U64_16800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2U64_16810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U64_16860	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U64_16865	COG0489	protein tyrosine kinase activity
C2U64_16875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U64_16875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U64_16910	COG3328	transposase activity
C2U64_16915	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C2U64_16920	COG2081	HI0933 family
C2U64_16930	COG0668	transmembrane transport
C2U64_16950	COG0583	DNA-binding transcription factor activity
C2U64_16970	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U64_16975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2U64_17005	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C2U64_17030	COG2199	diguanylate cyclase activity
C2U64_17040	COG2205	protein histidine kinase activity
C2U64_17045	COG0745	RESPONSE REGULATOR receiver
C2U64_17060	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U64_17080	COG2826	transposase and inactivated derivatives, IS30 family
C2U64_17110	COG0110	maltose O-acetyltransferase activity
C2U64_17115	COG0438	transferase activity, transferring glycosyl groups
C2U64_17190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U64_17195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2U64_17205	COG0583	DNA-binding transcription factor activity
C2U64_17240	COG0583	DNA-binding transcription factor activity
C2U64_17260	COG0583	DNA-binding transcription factor activity
C2U64_17265	COG1053	succinate dehydrogenase
C2U64_17290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U64_17295	COG2814	Major facilitator Superfamily
C2U64_17300	COG1960	acyl-CoA dehydrogenase activity
C2U64_17305	COG0583	DNA-binding transcription factor activity
C2U64_17330	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2U64_17335	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C2U64_17340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U64_17360	COG2132	Multicopper oxidase
C2U64_17370	COG0561	phosphatase activity
C2U64_17375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2U64_17385	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C2U64_17400	COG1214	PFAM Peptidase M22, glycoprotease
C2U64_17460	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2U64_17465	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2U64_17470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2U64_17530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U64_17540	COG1846	Transcriptional regulator
C2U64_17545	COG1764	response to oxidative stress
C2U64_17585	COG0037	tRNA processing
C2U64_17595	COG0248	Ppx GppA phosphatase
C2U64_17625	COG0072	phenylalanine-tRNA ligase activity
C2U64_17645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2U64_17650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2U64_17665	COG1238	metal cluster binding
C2U64_17670	COG0625	glutathione transferase activity
C2U64_17690	COG0318	PFAM AMP-dependent synthetase and ligase
C2U64_17695	COG3028	Belongs to the UPF0307 family
C2U64_17700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U64_17720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2U64_17725	COG0617	tRNA 3'-terminal CCA addition
C2U64_17730	COG1555	photosystem II stabilization
C2U64_17735	COG3956	TIGRFAM MazG family protein
C2U64_17740	COG4221	oxidoreductase activity
C2U64_17745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U64_17760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2U64_17765	COG0784	Response regulator, receiver
C2U64_17765	COG2205	protein histidine kinase activity
C2U64_17765	COG5002	protein histidine kinase activity
C2U64_17770	COG1024	Enoyl-CoA hydratase
C2U64_17775	COG2084	Dehydrogenase
C2U64_17780	COG3622	Belongs to the hyi family
C2U64_17795	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2U64_17800	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2U64_17805	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2U64_17810	COG0697	spore germination
C2U64_17820	COG2814	Major facilitator Superfamily
C2U64_17855	COG2072	flavoprotein involved in K transport
C2U64_17860	COG0492	ferredoxin-NADP+ reductase activity
C2U64_17865	COG0431	NADPH-dependent FMN reductase
C2U64_17870	COG0798	PFAM Bile acid sodium symporter
C2U64_17880	COG0640	Transcriptional regulator
C2U64_17915	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U64_17940	COG2132	Multicopper oxidase
C2U64_17955	COG2205	protein histidine kinase activity
C2U64_18035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U64_18050	COG0583	DNA-binding transcription factor activity
C2U64_18060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2U64_18070	COG0084	hydrolase, TatD family'
C2U64_18085	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C2U64_18100	COG2826	transposase and inactivated derivatives, IS30 family
C2U64_18120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2U64_18125	COG0440	acetolactate synthase activity
C2U64_18130	COG0028	Belongs to the TPP enzyme family
C2U64_18150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U64_18155	COG1136	(ABC) transporter
C2U64_18155	COG0577	efflux transmembrane transporter activity
C2U64_18190	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C2U64_18195	COG1162	GTPase activity
C2U64_18205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U64_18225	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U64_18245	COG1426	Protein conserved in bacteria
C2U64_18280	COG0793	Belongs to the peptidase S41A family
C2U64_18295	COG2267	carboxylic ester hydrolase activity
C2U64_18305	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_18310	COG3265	gluconokinase activity
C2U64_18320	COG0800	Aldolase
C2U64_18335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2U64_18340	COG0857	belongs to the CobB CobQ family
C2U64_18340	COG0280	phosphate acetyltransferase
C2U64_18345	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2U64_18345	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2U64_18365	COG0740	serine-type endopeptidase activity
C2U64_18375	COG4774	siderophore transport
C2U64_18385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U64_18395	COG2813	Specifically methylates the guanine in position
C2U64_18395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U64_18495	COG0788	formyltetrahydrofolate deformylase activity
C2U64_18510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2U64_18515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2U64_18520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U64_18520	COG4651	solute:proton antiporter activity
C2U64_18540	COG0724	RNA recognition motif
C2U64_18545	COG0210	DNA helicase
C2U64_18570	COG1733	regulation of RNA biosynthetic process
C2U64_18575	COG0604	alcohol dehydrogenase
C2U64_18580	COG2900	Belongs to the SlyX family
C2U64_18595	COG1560	Kdo2-lipid A biosynthetic process
C2U64_18605	COG1301	dicarboxylic acid transport
C2U64_18660	COG0473	3-isopropylmalate dehydrogenase activity
C2U64_18685	COG0583	DNA-binding transcription factor activity
C2U64_18730	COG0583	DNA-binding transcription factor activity
C2U64_18740	COG0625	glutathione transferase activity
C2U64_18745	COG2378	regulation of single-species biofilm formation
C2U64_18750	COG0546	phosphoglycolate phosphatase activity
C2U64_18765	COG1530	ribonuclease E activity
C2U64_18785	COG0583	DNA-binding transcription factor activity
C2U64_18790	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_18795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U64_18805	COG0534	Mate efflux family protein
C2U64_18820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2U64_18845	COG0493	'glutamate synthase
C2U64_18855	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C2U64_18860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U64_18875	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2U64_18885	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C2U64_18885	COG0644	oxidoreductase
C2U64_18900	COG4535	Mg2 and Co2 transporter CorC
C2U64_18910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U64_18930	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2U64_18940	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2U64_18950	COG0484	heat shock protein binding
C2U64_18955	COG0789	Transcriptional regulator
C2U64_18960	COG0598	Magnesium transport protein CorA
C2U64_18965	COG1185	polyribonucleotide nucleotidyltransferase activity
C2U64_18980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U64_18985	COG1074	ATP-dependent DNA helicase activity
C2U64_18990	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2U64_19010	COG2226	methyltransferase
C2U64_19025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U64_19050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2U64_19050	COG2111	Na H antiporter
C2U64_19055	COG1006	Multisubunit Na H antiporter MnhC subunit
C2U64_19060	COG0651	ATP synthesis coupled electron transport
C2U64_19070	COG2212	antiporter activity
C2U64_19080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2U64_19090	COG0195	Participates in both transcription termination and antitermination
C2U64_19140	COG0237	dephospho-CoA kinase activity
C2U64_19150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U64_19165	COG0497	DNA recombination
C2U64_19175	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2U64_19210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U64_19210	COG2169	Transcriptional regulator
C2U64_19215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2U64_19285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2U64_19300	COG0326	Molecular chaperone. Has ATPase activity
C2U64_19315	COG2056	Na+-H+ antiporter family
C2U64_19385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U64_19415	COG0546	phosphoglycolate phosphatase activity
C2U64_19420	COG1716	ATPase activity
C2U64_19465	COG0181	hydroxymethylbilane synthase activity
C2U64_19475	COG3275	phosphorelay sensor kinase activity
C2U64_19495	COG1538	Outer membrane efflux protein
C2U64_19505	COG0697	spore germination
C2U64_19525	COG0494	nUDIX hydrolase
C2U64_19530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2U64_19535	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U64_19540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U64_19545	COG0772	Belongs to the SEDS family
C2U64_19570	COG4974	Belongs to the 'phage' integrase family
C2U64_19575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U64_19585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U64_19595	COG2197	response regulator
C2U64_19610	COG0793	Belongs to the peptidase S41A family
C2U64_19615	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2U64_19620	COG0795	lipopolysaccharide-transporting ATPase activity
C2U64_19660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U64_19660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U64_19670	COG0004	ammonium transporteR
C2U64_19675	COG0347	Belongs to the P(II) protein family
C2U64_19685	COG0606	chelatase, subunit chli
C2U64_19690	COG0431	NADPH-dependent FMN reductase
C2U64_19695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U64_19700	COG0235	Class ii aldolase
C2U64_19705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U64_19725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2U64_19740	COG0318	PFAM AMP-dependent synthetase and ligase
C2U64_19750	COG0477	Major facilitator Superfamily
C2U64_19755	COG2860	membrane
C2U64_19765	COG1253	flavin adenine dinucleotide binding
C2U64_19775	COG2814	Major facilitator Superfamily
C2U64_19785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U64_19825	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2U64_19840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2U64_19870	COG1309	transcriptional regulator
C2U64_19905	COG0758	DNA mediated transformation
C2U64_19915	COG0697	spore germination
C2U64_19920	COG1309	transcriptional regulator
C2U64_19935	COG0386	Belongs to the glutathione peroxidase family
C2U64_19950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2U64_19960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2U64_20000	COG1121	(ABC) transporter
C2U64_20005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2U64_20010	COG1280	lysine exporter protein (LysE YggA)
C2U64_20015	COG2837	iron assimilation
C2U64_20020	COG0281	malic enzyme
C2U64_20065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U64_20065	COG0519	Catalyzes the synthesis of GMP from XMP
C2U64_20070	COG4399	Belongs to the UPF0754 family
C2U64_20075	COG2259	Doxx family
C2U64_20080	COG0586	Pfam SNARE associated Golgi protein
C2U64_20095	COG1192	Involved in chromosome partitioning
C2U64_20105	COG0271	Belongs to the BolA IbaG family
C2U64_20145	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2U64_20145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U64_20145	COG3321	synthase
C2U64_20145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2U64_20150	COG1960	acyl-CoA dehydrogenase activity
C2U64_20155	COG0318	PFAM AMP-dependent synthetase and ligase
C2U64_20160	COG2197	response regulator
C2U64_20170	COG3916	Acyl-homoserine-lactone synthase
C2U64_20175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U64_20185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U64_20190	COG1113	amino acid transport
C2U64_20195	COG0697	spore germination
C2U64_20200	COG0477	Major facilitator Superfamily
C2U64_20205	COG1024	Enoyl-CoA hydratase
C2U64_20210	COG1024	Enoyl-CoA hydratase
C2U64_20215	COG1960	acyl-CoA dehydrogenase activity
C2U64_20220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U64_20240	COG1113	amino acid transport
C2U64_20245	COG1113	amino acid transport
C2U64_20250	COG0251	oxidation-reduction process
C2U64_20265	COG1522	sequence-specific DNA binding
C2U64_20290	COG0564	pseudouridine synthase activity
C2U64_20310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U64_20325	COG1051	belongs to the nudix hydrolase family
C2U64_20345	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2U64_20360	COG1802	Transcriptional regulator
C2U64_20370	COG1448	Aminotransferase
C2U64_20375	COG0277	FAD linked oxidase domain protein
C2U64_20385	COG2186	Transcriptional regulator
C2U64_20395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U64_20410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2U64_20415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2U64_20450	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2U64_20460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2U64_20480	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2U64_20510	COG0728	peptidoglycan biosynthetic process
C2U64_20515	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2U64_20570	COG0546	phosphoglycolate phosphatase activity
C2U64_20575	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_20590	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2U64_20590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U64_20595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U64_20600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U64_20605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U64_20610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U64_20615	COG1116	anion transmembrane transporter activity
C2U64_20620	COG1309	transcriptional regulator
C2U64_20625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U64_20635	COG0196	riboflavin kinase activity
C2U64_20640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2U64_20650	COG1047	Peptidyl-prolyl cis-trans
C2U64_20690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U64_20745	COG2951	lytic endotransglycosylase activity
C2U64_20750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2U64_20765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U64_20775	COG3328	transposase activity
C2U64_20785	COG0671	phosphoesterase, PA-phosphatase related
C2U64_20790	COG0861	Integral membrane protein TerC family
C2U64_20800	COG0754	glutathionylspermidine amidase activity
C2U64_20810	COG0402	S-adenosylhomocysteine deaminase activity
C2U64_20825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U64_20845	COG0706	membrane insertase activity
C2U64_20860	COG0230	Belongs to the bacterial ribosomal protein bL34 family