locus-tag class description WP2W18E11_00020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) WP2W18E11_00040 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WP2W18E11_00070 ENOG4105C5H ABC transporter WP2W18E11_00080 ENOG4108821 RND type efflux pump WP2W18E11_00090 ENOG4108821 RND type efflux pump WP2W18E11_00100 ENOG4108821 RND type efflux pump WP2W18E11_00120 ENOG4105D74 hydrolase WP2W18E11_00130 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) WP2W18E11_00140 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) WP2W18E11_00170 ENOG4105C8J )-transporter WP2W18E11_00190 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B WP2W18E11_00250 ENOG4105C2W permease WP2W18E11_00270 ENOG4108IG5 Transcriptional regulator WP2W18E11_00280 ENOG4105DJY efflux transporter, rnd family, mfp subunit WP2W18E11_00350 ENOG4105F27 Major Facilitator WP2W18E11_00360 ENOG4105CV8 reductase WP2W18E11_00370 ENOG4105HEI LysR family (Transcriptional regulator WP2W18E11_00400 ENOG4105DQ4 alcohol dehydrogenase WP2W18E11_00410 ENOG4108R3E Dna-3-methyladenine glycosylase i WP2W18E11_00440 ENOG4105CEN a g-specific adenine glycosylase WP2W18E11_00480 ENOG4108ZZ3 UPF0260 protein WP2W18E11_00490 ENOG4105D8V Glucose sorbosone dehydrogenase WP2W18E11_00500 ENOG4105D1H recombination factor protein RarA WP2W18E11_00510 ENOG4105S64 Formate nitrite transporter WP2W18E11_00550 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WP2W18E11_00560 ENOG4108RWI nicotinamidase WP2W18E11_00570 ENOG4105C09 Bile acid WP2W18E11_00580 ENOG4107QI1 Mate efflux family protein WP2W18E11_00590 ENOG4105EWC Purine nucleoside phosphorylase WP2W18E11_00620 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) WP2W18E11_00630 ENOG4108RXX maleylacetoacetate isomerase WP2W18E11_00650 ENOG4105C85 amino acid WP2W18E11_00670 ENOG4105CKI cobalamin synthesis protein WP2W18E11_00690 ENOG4105CZE histidine utilization repressor WP2W18E11_00700 ENOG41090B9 response to stress WP2W18E11_00730 ENOG4105C85 amino acid WP2W18E11_00750 ENOG41088SP formiminoglutamate hydrolase WP2W18E11_00770 ENOG4105D9U N-acetyltransferase WP2W18E11_00820 ENOG4108JJA ABC, transporter WP2W18E11_00850 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 WP2W18E11_00860 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) WP2W18E11_00890 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) WP2W18E11_00910 ENOG4108ZAI phosphatidylglycerophosphatase a WP2W18E11_00920 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) WP2W18E11_00950 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) WP2W18E11_01020 ENOG4105KHC sulfurtransferase WP2W18E11_01080 ENOG4105BZU Histidine kinase WP2W18E11_01090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WP2W18E11_01120 ENOG4107QJQ Mate efflux family protein WP2W18E11_01130 ENOG4105CHM Aminotransferase WP2W18E11_01140 ENOG4106BRA Membrane WP2W18E11_01170 ENOG4105D9M gamma-glutamylcysteine synthetase WP2W18E11_01190 ENOG4105CS6 Rhs element vgr protein WP2W18E11_01260 ENOG4105IPS esterase WP2W18E11_01270 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WP2W18E11_01280 ENOG4108Z2U ureidoglycolate hydrolase WP2W18E11_01300 ENOG41061H0 Monooxygenase WP2W18E11_01330 ENOG41084YZ Hydrolase WP2W18E11_01390 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) WP2W18E11_01400 ENOG4105BZU Histidine kinase WP2W18E11_01430 ENOG4105KUZ arsenate reductase WP2W18E11_01440 ENOG4105CGK Exodeoxyribonuclease III WP2W18E11_01500 ENOG4105D7Z glutathione synthase WP2W18E11_01540 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) WP2W18E11_01550 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) WP2W18E11_01560 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) WP2W18E11_01590 ENOG41063SB peptidase WP2W18E11_01600 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) WP2W18E11_01610 ENOG4107QSN dihydrolipoamide acetyltransferase WP2W18E11_01640 ENOG4105E0K tonB-dependent siderophore receptor WP2W18E11_01660 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) WP2W18E11_01690 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) WP2W18E11_01710 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) WP2W18E11_01730 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WP2W18E11_01740 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase WP2W18E11_01760 ENOG4105D64 Mechanosensitive ion channel WP2W18E11_01780 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) WP2W18E11_01790 ENOG4108W2Y isochorismatase WP2W18E11_01810 ENOG4105FBW Monooxygenase WP2W18E11_01820 ENOG4108UZX fmn reductase WP2W18E11_01850 ENOG4105BZU Histidine kinase WP2W18E11_01860 ENOG41062QD Membrane WP2W18E11_01870 ENOG4107QN1 sodium solute WP2W18E11_01890 ENOG4105C94 Transporter WP2W18E11_01910 ENOG4105BZU Histidine kinase WP2W18E11_01920 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) WP2W18E11_01930 ENOG4108WUH Transcriptional regulator, TetR family WP2W18E11_01960 ENOG4105RA2 Membrane WP2W18E11_01970 ENOG4108IXY short-chain dehydrogenase reductase WP2W18E11_01990 ENOG4105DWF phosphomethylpyrimidine kinase WP2W18E11_02010 ENOG4107RDB Major Facilitator WP2W18E11_02020 ENOG4108UUM single-stranded DNA-binding protein WP2W18E11_02040 ENOG4108UMN azlc family WP2W18E11_02060 ENOG4105C85 amino acid WP2W18E11_02080 ENOG4108JPW Aminotransferase WP2W18E11_02090 ENOG4105C26 Dehydrogenase WP2W18E11_02110 ENOG4105CHJ isochorismatase hydrolase WP2W18E11_02120 ENOG4105EUB pirin domain protein WP2W18E11_02310 ENOG41082JN Transcriptional regulator WP2W18E11_02340 ENOG4105D94 Major Facilitator Superfamily WP2W18E11_02350 ENOG4106NZI LysR family Transcriptional regulator WP2W18E11_02390 ENOG4105CPC Aldo Keto reductase WP2W18E11_02400 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) WP2W18E11_02410 ENOG4105R8C Transcriptional regulator WP2W18E11_02450 ENOG4105KVH Transcriptional regulator WP2W18E11_02460 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein WP2W18E11_02580 ENOG4105CUV Homoserine Kinase WP2W18E11_02610 ENOG41061CK Antibiotic biosynthesis monooxygenase WP2W18E11_02640 ENOG4105BZ1 (ABC) transporter WP2W18E11_02680 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) WP2W18E11_02710 ENOG4108R6G acetyltransferase WP2W18E11_02720 ENOG4105CYC Transferase WP2W18E11_02730 ENOG4105E0F Histidine kinase WP2W18E11_02760 ENOG4105CHH sulfate transporter WP2W18E11_02770 ENOG4105PDP Short chain dehydrogenase WP2W18E11_02790 ENOG4105C5H ABC transporter WP2W18E11_02930 ENOG4108IQI permease WP2W18E11_02960 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein WP2W18E11_02990 ENOG4105CJN penicillin-binding protein WP2W18E11_03000 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) WP2W18E11_03010 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) WP2W18E11_03040 ENOG4105DHI Methyltransferase WP2W18E11_03050 ENOG4108JQC penicillin-binding protein 1A WP2W18E11_03100 ENOG4105E4G Type IV pilus WP2W18E11_03140 ENOG4105CBC glutamate synthase WP2W18E11_03150 ENOG4105BZ8 glutamate synthase WP2W18E11_03170 ENOG4108V0P LemA family WP2W18E11_03180 ENOG4105HA9 of methanol dehydrogenase type WP2W18E11_03220 ENOG4108YSG O-Antigen polymerase WP2W18E11_03230 ENOG4108UQY Iron-storage protein WP2W18E11_03250 ENOG4105KME endoribonuclease L-psp WP2W18E11_03260 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) WP2W18E11_03280 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) WP2W18E11_03380 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) WP2W18E11_03400 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) WP2W18E11_03410 ENOG4107IFA Lipase (EC 3.1.1.3) WP2W18E11_03420 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) WP2W18E11_03430 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) WP2W18E11_03460 ENOG4107AQZ Membrane WP2W18E11_03470 ENOG4107AQZ Membrane WP2W18E11_03480 ENOG4108JQ1 Dehydrogenase WP2W18E11_03490 ENOG4105CQB FAD linked oxidase domain protein WP2W18E11_03510 ENOG4105VRH Antibiotic biosynthesis monooxygenase WP2W18E11_03520 ENOG4105NF4 modulator of drug activity WP2W18E11_03540 ENOG4107QF7 multi-drug WP2W18E11_03550 ENOG4105EM2 membrane WP2W18E11_03560 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) WP2W18E11_03570 ENOG4105IPI Membrane WP2W18E11_03640 ENOG4108IQI permease WP2W18E11_03650 ENOG4105D82 Glutamate dehydrogenase WP2W18E11_03660 ENOG4105C8Y Acetylornithine aminotransferase WP2W18E11_03680 ENOG4105C26 Dehydrogenase WP2W18E11_03810 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit WP2W18E11_03890 ENOG41067S9 phage shock protein C, PspC WP2W18E11_03910 ENOG4105CSU acyl-Coa dehydrogenase WP2W18E11_03940 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) WP2W18E11_03970 ENOG4105ECY inositol monophosphatase WP2W18E11_03980 ENOG4105C1J atp-dependent rna helicase WP2W18E11_04000 ENOG4105DHJ ABC, transporter WP2W18E11_04010 ENOG4105CY3 ABC transporter, permease WP2W18E11_04030 ENOG4105E3I toluene tolerance WP2W18E11_04050 ENOG4105D7N magnesium and cobalt transport protein CorA WP2W18E11_04060 ENOG4108URH decarboxylase WP2W18E11_04080 ENOG4105MJ2 Competence protein WP2W18E11_04090 ENOG4105CB5 ATP-dependent DNA helicase recG WP2W18E11_04130 ENOG4105C29 acyl-CoA thioesterase WP2W18E11_04140 ENOG4105CK2 sodium dicarboxylate symporter WP2W18E11_04170 ENOG4105KPV Transcriptional regulator WP2W18E11_04190 ENOG4105D7A ATP-binding protein WP2W18E11_04210 ENOG41089BK Glutamine amido-transferase WP2W18E11_04230 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) WP2W18E11_04240 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) WP2W18E11_04430 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) WP2W18E11_04510 ENOG4105C1G acyl-Coa dehydrogenase WP2W18E11_04590 ENOG4105VKU nucleicacid-binding protein WP2W18E11_04600 ENOG4105DGW oligopeptidase A WP2W18E11_04610 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) WP2W18E11_04700 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase WP2W18E11_04710 ENOG4107S2Z UPF0761 membrane protein WP2W18E11_04720 ENOG4105CS1 NAD(P)H quinone oxidoreductase WP2W18E11_04780 ENOG4105C9A Phoh family WP2W18E11_04800 ENOG4105E4C Lytic transglycosylase catalytic WP2W18E11_04860 ENOG4105D6S protein involved in catabolism of external DNA WP2W18E11_04870 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase WP2W18E11_04910 ENOG4105C1G acyl-Coa dehydrogenase WP2W18E11_04930 ENOG4108RZE Tetr family transcriptional regulator WP2W18E11_04960 ENOG4107QX3 carboxylase WP2W18E11_04970 ENOG4105C1G acyl-Coa dehydrogenase WP2W18E11_05050 ENOG4105KB2 stringent starvation protein b WP2W18E11_05060 ENOG4107MKT Stringent starvation protein a WP2W18E11_05070 ENOG4108UJD 30S ribosomal protein S9 WP2W18E11_05080 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) WP2W18E11_05090 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) WP2W18E11_05100 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) WP2W18E11_05110 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) WP2W18E11_05150 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) WP2W18E11_05170 ENOG4107RZC phospholipase d WP2W18E11_05200 ENOG4108KHX Diguanylate cyclase WP2W18E11_05210 ENOG4108WS1 WP2W18E11_05230 ENOG4107QN2 dihydrolipoyl dehydrogenase WP2W18E11_05260 ENOG4107U2T alpha beta WP2W18E11_05280 ENOG4105NAU thioesterase Superfamily protein WP2W18E11_05350 ENOG4105K9H YciI-like protein WP2W18E11_05380 ENOG4105FFC UPF0187 protein WP2W18E11_05400 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase WP2W18E11_05410 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) WP2W18E11_05420 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) WP2W18E11_05430 ENOG4105VIE preprotein translocase, subunit YajC WP2W18E11_05460 ENOG4105BZU Histidine kinase WP2W18E11_05470 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) WP2W18E11_05480 ENOG4105CM2 brancheD-chain amino acid aminotransferase WP2W18E11_05500 ENOG4107BJW polysaccharide deacetylase WP2W18E11_05530 ENOG4107S6X Glycosyl transferase, family 2 WP2W18E11_05580 ENOG4105UGU tonB-dependent Receptor WP2W18E11_05630 ENOG4108K3A Glutathione S-transferase WP2W18E11_05640 ENOG4105EQ2 LysR family Transcriptional regulator WP2W18E11_05650 ENOG4105CSU acyl-Coa dehydrogenase WP2W18E11_05660 ENOG4105CSU acyl-Coa dehydrogenase WP2W18E11_05680 ENOG4105EB3 Histidine kinase WP2W18E11_05690 ENOG4105E3W Two component transcriptional regulator (Winged helix family WP2W18E11_05710 ENOG4105CNG UPF0061 protein WP2W18E11_05750 ENOG4108WBT adenosyltransferase WP2W18E11_05760 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) WP2W18E11_05850 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase WP2W18E11_05890 ENOG4105D3R alkyl hydroperoxide reductase WP2W18E11_05920 ENOG4105CSH Transporter WP2W18E11_05930 ENOG4108UT2 hemolysin iii WP2W18E11_05950 ENOG41082BV acetyltransferase WP2W18E11_05990 ENOG4105CHU acetyl-coa acetyltransferase WP2W18E11_06000 ENOG4108R6W Transcriptional regulator, ARAC family WP2W18E11_06020 ENOG4105TW1 Carbohydrate-selective porin OprB WP2W18E11_06030 ENOG4105DZG Dehydrogenase WP2W18E11_06040 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) WP2W18E11_06080 ENOG4105CHU acetyl-coa acetyltransferase WP2W18E11_06090 ENOG4105X0D Fimbrial protein WP2W18E11_06100 ENOG4108WHA ompa motb domain protein WP2W18E11_06120 ENOG4105E0Y RtcB Protein WP2W18E11_06130 ENOG4108IQI permease WP2W18E11_06150 ENOG4105C2W permease WP2W18E11_06160 ENOG4105CI3 gtp-binding protein typa WP2W18E11_06190 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) WP2W18E11_06210 ENOG4108VX5 3-methyladenine DNA glycosylase WP2W18E11_06220 ENOG4105CHB tonB-dependent Receptor WP2W18E11_06230 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WP2W18E11_06240 ENOG4108N2Y auxin Efflux WP2W18E11_06260 ENOG4105T95 Thiol disulfide interChange protein WP2W18E11_06270 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) WP2W18E11_06300 ENOG4105C2W permease WP2W18E11_06310 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) WP2W18E11_06320 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) WP2W18E11_06330 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) WP2W18E11_06340 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) WP2W18E11_06350 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) WP2W18E11_06360 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) WP2W18E11_06370 ENOG4105K78 MarR family Transcriptional regulator WP2W18E11_06380 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA WP2W18E11_06390 ENOG4105KWI UPF0339 protein WP2W18E11_06440 ENOG4108UNF response regulator WP2W18E11_06450 ENOG4105M3Z response regulator WP2W18E11_06460 ENOG4108ZGA chew protein WP2W18E11_06470 ENOG4105C8Q Methyl-accepting chemotaxis WP2W18E11_06480 ENOG4105CBS Chea signal transduction histidine kinase WP2W18E11_06520 ENOG4107PEH Entericidin EcnA/B family WP2W18E11_06540 ENOG4105WD1 Membrane WP2W18E11_06550 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein WP2W18E11_06570 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) WP2W18E11_06590 ENOG4105EM2 membrane WP2W18E11_06600 ENOG4105C2C drug resistance transporter, Bcr CflA WP2W18E11_06630 ENOG4105BZG amino acid carrier protein WP2W18E11_06640 ENOG4105D78 K07001 NTE family protein WP2W18E11_06650 ENOG4105C7B Threonine dehydratase WP2W18E11_06680 ENOG4105C9K Endothelin-converting enzyme 1 WP2W18E11_06730 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) WP2W18E11_06750 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) WP2W18E11_06770 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) WP2W18E11_06780 ENOG4105VQ7 Rod shape-determining protein MreD WP2W18E11_06790 ENOG4108Z03 MAF-like protein WP2W18E11_06800 ENOG4105C03 ribonuclease WP2W18E11_06820 ENOG4105D8T Acyltransferase WP2W18E11_06840 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein WP2W18E11_06860 ENOG4108X0B nad(p)h dehydrogenase (quinone) WP2W18E11_06910 ENOG4105CF7 AraC family transcriptional regulator WP2W18E11_07050 ENOG4105CDU Replicative dna helicase WP2W18E11_07150 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein WP2W18E11_07160 ENOG4105E09 nadh pyrophosphatase WP2W18E11_07170 ENOG4105C85 amino acid WP2W18E11_07180 ENOG4105C7F AcnD-accessory protein PrpF WP2W18E11_07190 ENOG4105CTB Polyprenyl synthetase WP2W18E11_07200 ENOG4105MSB protein, conserved in bacteria WP2W18E11_07230 ENOG4105D78 K07001 NTE family protein WP2W18E11_07270 ENOG4105DIJ Phosphoethanolamine transferase WP2W18E11_07280 ENOG4105XJC Two component transcriptional regulator (Winged helix family WP2W18E11_07290 ENOG4105DHQ Histidine kinase WP2W18E11_07320 ENOG4108M0I Transcriptional regulator WP2W18E11_07370 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) WP2W18E11_07410 ENOG4105K8R UPF0145 protein WP2W18E11_07420 ENOG4105K8R UPF0145 protein WP2W18E11_07430 ENOG4105ENJ RND efflux system, outer membrane lipoprotein WP2W18E11_07440 ENOG4105BZS acriflavin resistance protein WP2W18E11_07450 ENOG4105C1P efflux transporter, rnd family, mfp subunit WP2W18E11_07460 ENOG410841Q phosphoesterase PA-phosphatase related protein WP2W18E11_07510 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) WP2W18E11_07540 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) WP2W18E11_07550 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) WP2W18E11_07620 ENOG4105CUB amino acid WP2W18E11_07650 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) WP2W18E11_07660 ENOG41084BA UPF0250 protein WP2W18E11_07670 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WP2W18E11_07740 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit WP2W18E11_07750 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein WP2W18E11_07770 ENOG4105E33 succinate dehydrogenase WP2W18E11_07780 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 WP2W18E11_07790 ENOG4105C7S Dehydrogenase WP2W18E11_07800 ENOG4107QN2 dihydrolipoyl dehydrogenase WP2W18E11_07820 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha WP2W18E11_07840 ENOG4105CKW Inner membrane protein yedI WP2W18E11_07850 ENOG4105CGZ zinc metallopeptidase WP2W18E11_07860 ENOG4105EEQ Na H antiporter WP2W18E11_07910 ENOG4105PNM synthesis protein WP2W18E11_07950 ENOG41080TK Universal stress protein WP2W18E11_07970 ENOG4108UQ8 endoribonuclease L-psp WP2W18E11_07980 ENOG4108IG5 Transcriptional regulator WP2W18E11_08000 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain WP2W18E11_08010 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain WP2W18E11_08040 ENOG4105HBR Rna-binding protein WP2W18E11_08060 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) WP2W18E11_08070 ENOG4105EEI dihydropteroate synthase WP2W18E11_08140 ENOG4105CSH Transporter WP2W18E11_08150 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) WP2W18E11_08160 ENOG4105C6V Glycerol-3-phosphate dehydrogenase WP2W18E11_08190 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) WP2W18E11_08230 ENOG41080IJ Diacylglycerol kinase WP2W18E11_08250 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase WP2W18E11_08260 ENOG4105BZS acriflavin resistance protein WP2W18E11_08290 ENOG4105E4C Lytic transglycosylase catalytic WP2W18E11_08330 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) WP2W18E11_08340 ENOG4108RRZ Transcription elongation factor GreB WP2W18E11_08350 ENOG4105D01 (LipO)protein WP2W18E11_08390 ENOG4105C1P efflux transporter, rnd family, mfp subunit WP2W18E11_08400 ENOG4105BZS acriflavin resistance protein WP2W18E11_08440 ENOG4105BZW Glycerate kinase WP2W18E11_08450 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit WP2W18E11_08460 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) WP2W18E11_08490 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) WP2W18E11_08510 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) WP2W18E11_08520 ENOG4105BZG amino acid carrier protein WP2W18E11_08530 ENOG4105C85 amino acid WP2W18E11_08550 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) WP2W18E11_08570 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) WP2W18E11_08580 ENOG4105N14 lysine exporter protein LysE YggA WP2W18E11_08590 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WP2W18E11_08600 ENOG4105BZJ Electron transfer flavoprotein WP2W18E11_08610 ENOG4105C10 Electron transfer flavoprotein WP2W18E11_08620 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WP2W18E11_08650 ENOG4107KET secretion protein, HlyD family WP2W18E11_08720 ENOG4105D60 lipoprotein releasing system transmembrane protein WP2W18E11_08730 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) WP2W18E11_08740 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 WP2W18E11_08760 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) WP2W18E11_08770 ENOG4107R6F Alpha Beta Hydrolase Fold protein WP2W18E11_08780 ENOG4108V3E phosphoribosylglycinamide formyltransferase WP2W18E11_08800 ENOG4105C02 permease WP2W18E11_08900 ENOG4105KCK Peptidoglycan-associated lipoprotein WP2W18E11_08910 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) WP2W18E11_08930 ENOG4105M8F Biopolymer transport protein exbD tolR WP2W18E11_08940 ENOG4105E02 MotA TolQ exbB proton channel WP2W18E11_08950 ENOG4107YD3 Thioesterase WP2W18E11_08960 ENOG4105CH2 amidohydrolase WP2W18E11_09000 ENOG4108ETH Formylglycinamide ribotide synthetase WP2W18E11_09010 ENOG4105C2C drug resistance transporter, Bcr CflA WP2W18E11_09040 ENOG4108UKI Enoyl-CoA hydratase WP2W18E11_09080 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WP2W18E11_09100 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) WP2W18E11_09110 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) WP2W18E11_09140 ENOG4107R11 Transcriptional regulator WP2W18E11_09150 ENOG4108IJ6 ABC transporter WP2W18E11_09170 ENOG4108I5D sulfate abc transporter WP2W18E11_09190 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein WP2W18E11_09200 ENOG4105YAZ 4-amino-4-deoxychorismate lyase WP2W18E11_09210 ENOG4105HHA aminodeoxychorismate lyase WP2W18E11_09240 ENOG4108IYU L-aspartate oxidase WP2W18E11_09250 ENOG4105C0H protease WP2W18E11_09280 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) WP2W18E11_09290 ENOG4105C3F Signal peptidase i WP2W18E11_09310 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) WP2W18E11_09320 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) WP2W18E11_09340 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) WP2W18E11_09350 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) WP2W18E11_09360 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase WP2W18E11_09370 ENOG4105EMU Dehydrogenase WP2W18E11_09430 ENOG4105BZU Histidine kinase WP2W18E11_09450 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) WP2W18E11_09470 ENOG4105DTR rard protein WP2W18E11_09540 ENOG4107QS8 (LipO)protein WP2W18E11_09550 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) WP2W18E11_09560 ENOG4105EA8 2-Nitropropane dioxygenase WP2W18E11_09590 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase WP2W18E11_09620 ENOG4107R8N Glycosyl transferase, family 2 WP2W18E11_09650 ENOG4105CVP deoxyribo-dipyrimidine photolyase WP2W18E11_09660 ENOG4108YZY peptidylprolyl cis-trans isomerase WP2W18E11_09670 ENOG4105CEP NADH dehydrogenase WP2W18E11_09680 ENOG4105DZ1 carboxypeptidase WP2W18E11_09700 ENOG4105E9K Isocitrate dehydrogenase WP2W18E11_09710 ENOG4108R99 pseudouridine synthase WP2W18E11_09740 ENOG4105CBP Major Facilitator WP2W18E11_09750 ENOG4105EGI Transcriptional regulator WP2W18E11_09760 ENOG4108ETY sodium dicarboxylate symporter WP2W18E11_09770 ENOG4105JAB phenazine biosynthesis protein, phzf family WP2W18E11_09830 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) WP2W18E11_09860 ENOG4105D3G Pseudouridine synthase WP2W18E11_09870 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) WP2W18E11_09900 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) WP2W18E11_09930 ENOG4108JPW Aminotransferase WP2W18E11_09940 ENOG4105DY8 decarboxylase WP2W18E11_09960 ENOG4105F7P transcriptional regulator AsnC family WP2W18E11_09970 ENOG4107RA9 decarboxylase WP2W18E11_09980 ENOG4105C85 amino acid WP2W18E11_09990 ENOG4105CVA phosphate WP2W18E11_10000 ENOG4105C8U phosphate abc transporter WP2W18E11_10020 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) WP2W18E11_10030 ENOG4105ERU peptidase WP2W18E11_10060 ENOG4107QTF adenylosuccinate lyase WP2W18E11_10100 ENOG4108Z0R Transferase WP2W18E11_10110 ENOG4105DZ1 carboxypeptidase WP2W18E11_10150 ENOG4108K5P (LipO)protein WP2W18E11_10160 ENOG4105EJC lysr family transcriptional regulator WP2W18E11_10170 ENOG4105DAN ATP-dependent protease WP2W18E11_10180 ENOG4105EYM Major Facilitator superfamily WP2W18E11_10200 ENOG4105DHU Bile acid WP2W18E11_10240 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein WP2W18E11_10250 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) WP2W18E11_10260 ENOG4105D22 carbon starvation protein WP2W18E11_10270 ENOG4105VCD cytoplasmic protein WP2W18E11_10310 ENOG4105CK2 sodium dicarboxylate symporter WP2W18E11_10330 ENOG41061TZ Short-chain dehydrogenase reductase Sdr WP2W18E11_10380 ENOG4107QP7 CoA-transferase subunit A WP2W18E11_10390 ENOG4107QNJ CoA-transferase subunit B WP2W18E11_10400 ENOG4105CHU acetyl-coa acetyltransferase WP2W18E11_10410 ENOG4105NN7 muconolactone delta-isomerase WP2W18E11_10460 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) WP2W18E11_10470 ENOG4105C2I pirin domain protein WP2W18E11_10500 ENOG4105CEY Amp-dependent synthetase and ligase WP2W18E11_10550 ENOG4108IPW abc transporter atp-binding protein WP2W18E11_10590 ENOG4105C0W non-ribosomal peptide synthetase WP2W18E11_10600 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase WP2W18E11_10610 ENOG4105WQI isochorismatase WP2W18E11_10640 ENOG4105BZ1 (ABC) transporter WP2W18E11_10650 ENOG4108JJ7 ABC transporter WP2W18E11_10680 ENOG4105E4F Isochorismate synthase WP2W18E11_10710 ENOG4105NX3 Membrane WP2W18E11_10740 ENOG41066YJ Beta-lactamase WP2W18E11_10750 ENOG4105EUJ GTP cyclohydrolase i WP2W18E11_10770 ENOG4105C7W Xanthine dehydrogenase WP2W18E11_10790 ENOG4108DG9 Smr protein MutS2 WP2W18E11_10840 ENOG4105DDQ anthranilate synthase WP2W18E11_10860 ENOG4105DUX Transporter WP2W18E11_10890 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) WP2W18E11_10930 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) WP2W18E11_10940 ENOG4107QNR UPF0135 protein WP2W18E11_10950 ENOG4105C0H protease WP2W18E11_10970 ENOG4105C6K Malic enzyme WP2W18E11_10980 ENOG4105BZU Histidine kinase WP2W18E11_10990 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) WP2W18E11_11000 ENOG4105SYT Methylenetetrahydrofolate reductase WP2W18E11_11010 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) WP2W18E11_11040 ENOG4107QPN acyl-Coa dehydrogenase WP2W18E11_11050 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) WP2W18E11_11060 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) WP2W18E11_11090 ENOG4107RNU major facilitator superfamily MFS_1 WP2W18E11_11110 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) WP2W18E11_11120 ENOG4105CE9 30S ribosomal protein S2 WP2W18E11_11200 ENOG4105CVE Lytic murein transglycosylase WP2W18E11_11210 ENOG4105CNI cell division protein FtsW WP2W18E11_11240 ENOG4105E3A (ABC) transporter WP2W18E11_11250 ENOG4105DA5 (ABC) transporter WP2W18E11_11310 ENOG4105ENT Efflux transporter rnd family, mfp subunit WP2W18E11_11330 ENOG4105E89 ABC transporter WP2W18E11_11340 ENOG4105DSP amino acid AbC transporter WP2W18E11_11350 ENOG4106YG3 ABC transporter WP2W18E11_11360 ENOG4108JEH abc transporter atp-binding protein WP2W18E11_11380 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding WP2W18E11_11390 ENOG4105CFP Peptidase U32 WP2W18E11_11400 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WP2W18E11_11410 ENOG4105JAB phenazine biosynthesis protein, phzf family WP2W18E11_11420 ENOG4105DP0 ferredoxin-NADP reductase WP2W18E11_11430 ENOG4108R96 Methyltransferase, YaeB family WP2W18E11_11450 ENOG4107QHF type ii secretion system protein e WP2W18E11_11470 ENOG4105XJC Two component transcriptional regulator (Winged helix family WP2W18E11_11480 ENOG4105DHQ Histidine kinase WP2W18E11_11500 ENOG4105M6F mutator MutT protein WP2W18E11_11520 ENOG4105BZ4 penicillin-binding protein WP2W18E11_11530 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) WP2W18E11_11540 ENOG4105VUT cytoplasmic protein WP2W18E11_11560 ENOG4105CK2 sodium dicarboxylate symporter WP2W18E11_11570 ENOG4105C1G acyl-Coa dehydrogenase WP2W18E11_11600 ENOG4105CQC Prephenate dehydratase WP2W18E11_11610 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase WP2W18E11_11630 ENOG4105E6M Sulphatase-modifying factor protein WP2W18E11_11640 ENOG4105CIN aminoacyl-histidine dipeptidase WP2W18E11_11680 ENOG4105E0Y RtcB Protein WP2W18E11_11690 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) WP2W18E11_11700 ENOG4105CYB regulatoR WP2W18E11_11750 ENOG4105M08 Membrane WP2W18E11_11760 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WP2W18E11_11780 ENOG4105VEQ Cold shock protein WP2W18E11_11790 ENOG4105C1J atp-dependent rna helicase WP2W18E11_11810 ENOG41069NU Nitroreductase WP2W18E11_11880 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase WP2W18E11_11910 ENOG4105C5I Dehydrogenase WP2W18E11_11920 ENOG4105ERG peptidase m48, ste24p WP2W18E11_11930 ENOG4105KTH gatB Yqey WP2W18E11_11990 ENOG4105D9P serine threonine protein kinase WP2W18E11_12000 ENOG4105VEQ Cold shock protein WP2W18E11_12040 ENOG4105D6U Sodium Glutamate Symporter WP2W18E11_12050 ENOG4105CKD glutathione-regulated potassium-efflux system protein WP2W18E11_12060 ENOG4105H9W Short-chain dehydrogenase reductase Sdr WP2W18E11_12170 ENOG4105R8C Transcriptional regulator WP2W18E11_12180 ENOG4105CEB Aspartate aminotransferase WP2W18E11_12220 ENOG4105F1S paraquat-inducible protein a WP2W18E11_12230 ENOG4105DY2 Paraquat-inducible protein b WP2W18E11_12250 ENOG4105VT2 5-hydroxyisourate hydrolase WP2W18E11_12280 ENOG4105GR3 Histidine kinase WP2W18E11_12330 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase WP2W18E11_12350 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase WP2W18E11_12360 ENOG4105DHQ Histidine kinase WP2W18E11_12370 ENOG4105ETX regulatoR WP2W18E11_12460 ENOG4105CK2 sodium dicarboxylate symporter WP2W18E11_12480 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) WP2W18E11_12490 ENOG4108UMI ABC transporter, permease WP2W18E11_12500 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) WP2W18E11_12510 ENOG4105D01 (LipO)protein WP2W18E11_12520 ENOG4105C12 Phosphoribosylglycinamide synthetase WP2W18E11_12540 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) WP2W18E11_12640 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) WP2W18E11_12650 ENOG4105CDU Replicative dna helicase WP2W18E11_12700 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) WP2W18E11_12710 ENOG4105CCU oxidase (Subunit III) WP2W18E11_12720 ENOG4105BZ9 Cytochrome C oxidase, subunit I WP2W18E11_12730 ENOG4105E2S oxidase) subunit II WP2W18E11_12780 ENOG4107BJW polysaccharide deacetylase WP2W18E11_12790 ENOG4105CND Glycosyl transferase, family 2 WP2W18E11_12820 ENOG4105DEN Luciferase family WP2W18E11_12840 ENOG4105CC0 LysR family Transcriptional regulator WP2W18E11_12870 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) WP2W18E11_12880 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component WP2W18E11_12890 ENOG4105GVF (ABC) transporter WP2W18E11_12920 ENOG4105C1G acyl-Coa dehydrogenase WP2W18E11_12930 ENOG4108MEJ flavin reductase domain protein WP2W18E11_12940 ENOG4105D06 uba thif-type nad fad binding protein WP2W18E11_12960 ENOG4105KRF dihydroneopterin aldolase WP2W18E11_12990 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) WP2W18E11_13000 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) WP2W18E11_13020 ENOG4105C08 Histidine kinase WP2W18E11_13030 ENOG4105EEX Two component transcriptional regulator (Winged helix family WP2W18E11_13040 ENOG4105CFQ glutamine synthetase WP2W18E11_13070 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) WP2W18E11_13080 ENOG4105CFU surface antigen WP2W18E11_13120 ENOG4107QIJ Aconitate hydratase 2 WP2W18E11_13140 ENOG4105EYW Ion transport protein WP2W18E11_13150 ENOG4105F27 Major Facilitator WP2W18E11_13180 ENOG4105F27 Major Facilitator WP2W18E11_13200 ENOG4105DZ2 Transcriptional regulator WP2W18E11_13230 ENOG4105I08 Pseudouridine synthase WP2W18E11_13260 ENOG4105C34 Pseudouridine synthase WP2W18E11_13270 ENOG4105K8N protein family UPF0079, ATPase WP2W18E11_13280 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) WP2W18E11_13300 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) WP2W18E11_13310 ENOG4108TZV Membrane WP2W18E11_13320 ENOG4108RCM Nitroreductase WP2W18E11_13330 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) WP2W18E11_13350 ENOG4105CX6 glutaminyL-tRNA synthetase WP2W18E11_13360 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) WP2W18E11_13370 ENOG4107FQ9 ethanolamine ammonia-lyase WP2W18E11_13380 ENOG4105CPD ethanolamine ammonia-lyase WP2W18E11_13390 ENOG4107R55 ethanolamine transporter WP2W18E11_13410 ENOG4107RR1 TRANSCRIPTIONal WP2W18E11_13430 ENOG4105C0A alcohol dehydrogenase WP2W18E11_13440 ENOG4107QUV Domain protein WP2W18E11_13490 ENOG4105CD8 aminopeptidase N WP2W18E11_13520 ENOG4108D1K outer membrane usher protein WP2W18E11_13570 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) WP2W18E11_13600 ENOG4105GAV receptor WP2W18E11_13610 ENOG4108ESX Receptor WP2W18E11_13670 ENOG41089BK Glutamine amido-transferase WP2W18E11_13740 ENOG4105KUS lysozyme WP2W18E11_13840 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium WP2W18E11_13850 ENOG4105C5H ABC transporter WP2W18E11_13860 ENOG41081QV Universal stress protein WP2W18E11_13900 ENOG4105DKK Benzoate WP2W18E11_13910 ENOG4105EW9 transcriptional regulator AsnC family WP2W18E11_13920 ENOG4108NIW Leucine export protein LeuE WP2W18E11_13940 ENOG4105CC0 LysR family Transcriptional regulator WP2W18E11_13960 ENOG4105CHU acetyl-coa acetyltransferase WP2W18E11_13970 ENOG4105CHR reductase WP2W18E11_14040 ENOG4107QMP dna polymerase iii subunits gamma and tau WP2W18E11_14050 ENOG4105HSS phospholipase C WP2W18E11_14070 ENOG4105C0A alcohol dehydrogenase WP2W18E11_14180 ENOG4105CBC glutamate synthase WP2W18E11_14220 ENOG4108D1K outer membrane usher protein WP2W18E11_14550 ENOG4107ZQ5 Phage-associated protein, HI1409 family WP2W18E11_14590 ENOG41090AG Bacteriophage protein WP2W18E11_14810 ENOG4105DIJ Phosphoethanolamine transferase WP2W18E11_14830 ENOG4105D8G Major Facilitator superfamily WP2W18E11_14850 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase WP2W18E11_14860 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein WP2W18E11_14910 ENOG4105DUU IucA IucC family protein WP2W18E11_14930 ENOG4105DJU Siderophore biosynthesis protein WP2W18E11_14940 ENOG4105CIF Ornithine Cyclodeaminase WP2W18E11_14990 ENOG4107QZF nitrite reductase NADPH large subunit WP2W18E11_15000 ENOG4108IFG nitrite reductase, (NAD(P)H) WP2W18E11_15070 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) WP2W18E11_15080 ENOG4105CVM Molybdenum cofactor synthesis domain protein WP2W18E11_15100 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WP2W18E11_15110 ENOG4105T38 integral membrane protein WP2W18E11_15160 ENOG4105CMR udp-glucose 4-epimerase WP2W18E11_15300 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WP2W18E11_15310 ENOG4105CUX Signal transduction histidine kinase WP2W18E11_15350 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) WP2W18E11_15360 ENOG4105KNE Phosphatidate cytidylyltransferase WP2W18E11_15380 ENOG4105DZP Membrane-associated zinc metalloprotease WP2W18E11_15430 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) WP2W18E11_15450 ENOG4105Y3E Modulates RecA activity (By similarity) WP2W18E11_15470 ENOG4105VEJ Heat shock protein WP2W18E11_15480 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 WP2W18E11_15510 ENOG4105F7P transcriptional regulator AsnC family WP2W18E11_15530 ENOG4105C85 amino acid WP2W18E11_15590 ENOG4105CHH sulfate transporter WP2W18E11_15610 ENOG4105D8V Glucose sorbosone dehydrogenase WP2W18E11_15630 ENOG4105BZU Histidine kinase WP2W18E11_15660 ENOG4105DM4 PTS System WP2W18E11_15670 ENOG4105DE4 1-phosphofructokinase WP2W18E11_15680 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) WP2W18E11_15720 ENOG4108ZJF Glcg protein WP2W18E11_15730 ENOG4105CWM branched-chain amino acid transport system II carrier protein WP2W18E11_15740 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) WP2W18E11_15750 ENOG4105CC0 LysR family Transcriptional regulator WP2W18E11_15770 ENOG4105M2J Glutaredoxin WP2W18E11_15780 ENOG4105C8Y Acetylornithine aminotransferase WP2W18E11_15790 ENOG4105C2X Arabinose 5-phosphate isomerase WP2W18E11_15840 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) WP2W18E11_15890 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii WP2W18E11_15900 ENOG4105C4M (Ubiquinol oxidase) subunit I WP2W18E11_15920 ENOG4105PV3 Inner membrane protein yqiJ WP2W18E11_15960 ENOG4105HDD phospholipase WP2W18E11_15970 ENOG4105CZN Potassium uptake protein WP2W18E11_15990 ENOG4105C7B Threonine dehydratase WP2W18E11_16050 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) WP2W18E11_16060 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit WP2W18E11_16080 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) WP2W18E11_16110 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WP2W18E11_16190 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) WP2W18E11_16200 ENOG4107VMU Membrane WP2W18E11_16250 ENOG4105CNM Receptor WP2W18E11_16290 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) WP2W18E11_16310 ENOG4107QP7 CoA-transferase subunit A WP2W18E11_16320 ENOG4107QNJ CoA-transferase subunit B WP2W18E11_16330 ENOG4105CHU acetyl-coa acetyltransferase WP2W18E11_16340 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase WP2W18E11_16350 ENOG4105F2Z 3-oxoadipate enol-lactonase WP2W18E11_16360 ENOG4105D2S major facilitator superfamily WP2W18E11_16370 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase WP2W18E11_16380 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta WP2W18E11_16390 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha WP2W18E11_16400 ENOG4105FF2 Type I DHQase WP2W18E11_16410 ENOG4106JPM 3-dehydroshikimate dehydratase WP2W18E11_16420 ENOG4105TW1 Carbohydrate-selective porin OprB WP2W18E11_16430 ENOG4105DZG Dehydrogenase WP2W18E11_16450 ENOG4105MD1 YeeE YedE family protein WP2W18E11_16480 ENOG4107HP6 Transcriptional regulator WP2W18E11_16490 ENOG4108PTX LysR family Transcriptional regulator WP2W18E11_16500 ENOG4105C1G acyl-Coa dehydrogenase WP2W18E11_16550 ENOG4105DNH Major Facilitator WP2W18E11_16570 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) WP2W18E11_16610 ENOG4105FUY alpha subunit WP2W18E11_16630 ENOG4105CHR reductase WP2W18E11_16670 ENOG4105F11 amine oxidase WP2W18E11_16690 ENOG4105C26 Dehydrogenase WP2W18E11_16700 ENOG4105F2Z 3-oxoadipate enol-lactonase WP2W18E11_16710 ENOG4105CHU acetyl-coa acetyltransferase WP2W18E11_16720 ENOG4107QNJ CoA-transferase subunit B WP2W18E11_16730 ENOG4107QP7 CoA-transferase subunit A WP2W18E11_16750 ENOG4105NN7 muconolactone delta-isomerase WP2W18E11_16760 ENOG4105DTQ mandelate racemase muconate lactonizing WP2W18E11_16770 ENOG4108KB2 LysR family Transcriptional regulator WP2W18E11_16790 ENOG4107EJG GntR family transcriptional regulator WP2W18E11_16830 ENOG4105CZJ Aldehyde dehydrogenase WP2W18E11_16840 ENOG4105VT2 5-hydroxyisourate hydrolase WP2W18E11_16850 ENOG4105C2W permease WP2W18E11_16870 ENOG41061H0 Monooxygenase WP2W18E11_16880 ENOG41073TP transcriptional regulator WP2W18E11_16900 ENOG4107XKF NMT1 THI5 Like Domain Protein WP2W18E11_16920 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component WP2W18E11_16960 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WP2W18E11_17030 ENOG4107Z3H Transcriptional regulator, TetR family WP2W18E11_17040 ENOG4108PTX LysR family Transcriptional regulator WP2W18E11_17050 ENOG41061TZ Short-chain dehydrogenase reductase Sdr WP2W18E11_17060 ENOG41061TZ Short-chain dehydrogenase reductase Sdr WP2W18E11_17070 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr WP2W18E11_17090 ENOG4105CSU acyl-Coa dehydrogenase WP2W18E11_17110 ENOG4105CEY Amp-dependent synthetase and ligase WP2W18E11_17130 ENOG4105J7D transcriptional regulator WP2W18E11_17150 ENOG4105D2S major facilitator superfamily WP2W18E11_17190 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) WP2W18E11_17200 ENOG4108VBZ doxx family WP2W18E11_17210 ENOG4108K3A Glutathione S-transferase WP2W18E11_17220 ENOG4105DZG Dehydrogenase WP2W18E11_17330 ENOG4106P55 Transcriptional regulator WP2W18E11_17380 ENOG4108JQ1 Dehydrogenase WP2W18E11_17390 ENOG4105JSC dimethylmenaquinone methyltransferase WP2W18E11_17420 ENOG4105EVZ LysR family transcriptional regulator WP2W18E11_17430 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WP2W18E11_17440 ENOG4105C26 Dehydrogenase WP2W18E11_17480 ENOG4105MSY salicylate hydroxylase WP2W18E11_17560 ENOG4105CF7 AraC family transcriptional regulator WP2W18E11_17570 ENOG4105DQ4 alcohol dehydrogenase WP2W18E11_17600 ENOG4105EHG Permease protein WP2W18E11_17610 ENOG4105E0A ABC, transporter WP2W18E11_17650 ENOG4105C5T Phosphoribosyl pyrophosphate synthase WP2W18E11_17740 ENOG4108UAJ Transcriptional regulator WP2W18E11_17820 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) WP2W18E11_17900 ENOG4105ENX hydrolase WP2W18E11_17910 ENOG4105EQ2 LysR family Transcriptional regulator WP2W18E11_17920 ENOG4108BAS reductase WP2W18E11_17950 ENOG4108R6W Transcriptional regulator, ARAC family WP2W18E11_17960 ENOG4108821 RND type efflux pump WP2W18E11_17970 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) WP2W18E11_18010 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) WP2W18E11_18020 ENOG4107QKA exodeoxyribonuclease V beta WP2W18E11_18160 ENOG4105X0I Fimbrial WP2W18E11_18280 ENOG4107RZC phospholipase d WP2W18E11_18300 ENOG4105JJR Histidine kinase WP2W18E11_18310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WP2W18E11_18320 ENOG4105C1P efflux transporter, rnd family, mfp subunit WP2W18E11_18330 ENOG4105BZS acriflavin resistance protein WP2W18E11_18360 ENOG4108IGT Dipeptidase WP2W18E11_18370 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E WP2W18E11_18390 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) WP2W18E11_18400 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) WP2W18E11_18410 ENOG4107T31 5'-nucleotidase WP2W18E11_18430 ENOG4105WQI isochorismatase WP2W18E11_18440 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase WP2W18E11_18450 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) WP2W18E11_18460 ENOG4105E0C molybdate abc transporter WP2W18E11_18470 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein WP2W18E11_18480 ENOG4105F4R Transcriptional regulator mode WP2W18E11_18490 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit WP2W18E11_18500 ENOG4108YS2 small subunit WP2W18E11_18510 ENOG4105F57 Anthranilate dioxygenase reductase WP2W18E11_18560 ENOG4105CHR reductase WP2W18E11_18590 ENOG4105D2S major facilitator superfamily WP2W18E11_18600 ENOG4105CF7 AraC family transcriptional regulator WP2W18E11_18610 ENOG4105DTD Dehydrogenase WP2W18E11_18620 ENOG4105CY2 Citrate transporter WP2W18E11_18680 ENOG4108M0I Transcriptional regulator WP2W18E11_18710 ENOG4105CRW Short chain fatty acid transporter WP2W18E11_18720 ENOG4105CHU acetyl-coa acetyltransferase WP2W18E11_18740 ENOG4107YNJ LysR family Transcriptional regulator WP2W18E11_18770 ENOG4108IJ0 Aspartate ammonia-lyase WP2W18E11_18790 ENOG4105CSH Transporter WP2W18E11_18810 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) WP2W18E11_18820 ENOG4105KVH Transcriptional regulator WP2W18E11_18830 ENOG4105UEI Transcriptional Regulator AraC Family WP2W18E11_18860 ENOG4108VCT Sulfite exporter TauE/SafE WP2W18E11_18900 ENOG4105FFC UPF0187 protein WP2W18E11_18920 ENOG4105CHR reductase WP2W18E11_18950 ENOG4105CPP Dehydrogenase, E1 component WP2W18E11_18960 ENOG4107R0V Pyruvate dehydrogenase WP2W18E11_18970 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) WP2W18E11_19000 ENOG4105BZU Histidine kinase WP2W18E11_19030 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) WP2W18E11_19040 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) WP2W18E11_19130 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) WP2W18E11_19150 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) WP2W18E11_19180 ENOG4105C28 cystathionine WP2W18E11_19220 ENOG4105K59 histidine triad (HIT) protein WP2W18E11_19270 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) WP2W18E11_19280 ENOG4105CNM Receptor WP2W18E11_19320 ENOG4107TSN permease WP2W18E11_19330 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) WP2W18E11_19370 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) WP2W18E11_19380 ENOG4108YZT Adenosylcobinamide kinase WP2W18E11_19400 ENOG4107VXZ Hydrolase WP2W18E11_19420 ENOG4108Z66 YbaK ebsC protein WP2W18E11_19450 ENOG4105C1G acyl-Coa dehydrogenase WP2W18E11_19460 ENOG4105C1G acyl-Coa dehydrogenase WP2W18E11_19470 ENOG4105EEF Alkane 1-monooxygenase WP2W18E11_19480 ENOG4105E7U AraC family transcriptional regulator WP2W18E11_19490 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) WP2W18E11_19500 ENOG4105K70 DNA-binding protein WP2W18E11_19530 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family WP2W18E11_19550 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins WP2W18E11_19560 ENOG4108Z4V iron-sulfur cluster assembly WP2W18E11_19590 ENOG4108ZIT Ferredoxin, 2FE-2S WP2W18E11_19600 ENOG4105F8J Adenylate Guanylate cyclase WP2W18E11_19620 ENOG4108JA2 transcriptioN-repair coupling factor WP2W18E11_19660 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) WP2W18E11_19670 ENOG4105K4T epimerase WP2W18E11_19700 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase WP2W18E11_19760 ENOG4105DGW oligopeptidase A WP2W18E11_19770 ENOG4107QSI ABC, transporter WP2W18E11_19830 ENOG4105SG9 biopolymer transport protein, ExbD WP2W18E11_19850 ENOG4107QP3 malate synthase g WP2W18E11_19860 ENOG4105D6Z AFG1 family ATPase WP2W18E11_19880 ENOG4107RN6 Monooxygenase WP2W18E11_19890 ENOG4105DWU Membrane WP2W18E11_19920 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) WP2W18E11_19930 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) WP2W18E11_19960 ENOG4108Z6B deaminase WP2W18E11_20000 ENOG4108RTD type II secretion system protein K WP2W18E11_20050 ENOG4105F8V Hydrolase, tatD family WP2W18E11_20070 ENOG4107QRG dna polymerase iii WP2W18E11_20090 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) WP2W18E11_20100 ENOG4105BZ1 (ABC) transporter WP2W18E11_20130 ENOG4105FA0 parb-like partition protein WP2W18E11_20140 ENOG4107QJE Chromosome Partitioning Protein WP2W18E11_20160 ENOG4108S0S Nucleotidyl transferase WP2W18E11_20170 ENOG4105EHM Aminoglycoside phosphotransferase WP2W18E11_20180 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) WP2W18E11_20190 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) WP2W18E11_20200 ENOG4105D2N Aldolase WP2W18E11_20240 ENOG4108UHJ MAF-like protein WP2W18E11_20250 ENOG4105EZE Cupin 4 family protein WP2W18E11_20270 ENOG41080HT Transcriptional regulator, arsr family WP2W18E11_20290 ENOG4105XPP Protein of unknown function (DUF1275) WP2W18E11_20300 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme WP2W18E11_20320 ENOG4105BZ1 (ABC) transporter WP2W18E11_20340 ENOG4108ZX5 transcriptional regulator WP2W18E11_20360 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) WP2W18E11_20370 ENOG4105CK7 Sodium proline symporter WP2W18E11_20380 ENOG4105EW9 transcriptional regulator AsnC family WP2W18E11_20390 ENOG4105C26 Dehydrogenase WP2W18E11_20430 ENOG4108T58 Mg2 transport protein CorA WP2W18E11_20450 ENOG4108YYC ycei family WP2W18E11_20470 ENOG4105CV1 Transketolase (EC 2.2.1.1) WP2W18E11_20520 ENOG4108HWY Beta-lactamase WP2W18E11_20560 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) WP2W18E11_20570 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) WP2W18E11_20610 ENOG4105X0I Fimbrial WP2W18E11_20670 ENOG4108IPJ Membrane WP2W18E11_20690 ENOG4105ETS cytosine purines uracil thiamine allantoin WP2W18E11_20710 ENOG4105HEI LysR family (Transcriptional regulator WP2W18E11_20730 ENOG41067SE Tetr family transcriptional regulator WP2W18E11_20760 ENOG4105EW9 transcriptional regulator AsnC family WP2W18E11_20780 ENOG4105CDA abc transporter atp-binding protein WP2W18E11_20790 ENOG4105DRP amino acid AbC transporter WP2W18E11_20800 ENOG4105EAD ABC transporter WP2W18E11_20830 ENOG4107T8P acyl-Coa dehydrogenase WP2W18E11_20860 ENOG4105D01 (LipO)protein WP2W18E11_20870 ENOG4105D01 (LipO)protein WP2W18E11_20880 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) WP2W18E11_20890 ENOG4108UMI ABC transporter, permease WP2W18E11_20900 ENOG4105C3G gtp-binding protein WP2W18E11_20950 ENOG4108UMN azlc family WP2W18E11_20960 ENOG4105ZED uncharacterized protein ygaH WP2W18E11_21020 ENOG4105E7U AraC family transcriptional regulator WP2W18E11_21030 ENOG4108V06 Glutathione peroxidase WP2W18E11_21050 ENOG4105CHM Aminotransferase WP2W18E11_21060 ENOG4105CK2 sodium dicarboxylate symporter WP2W18E11_21080 ENOG4105C0B DNA polymerase III (alpha subunit) WP2W18E11_21130 ENOG4108JU3 Alkyl hydroperoxide reductase WP2W18E11_21160 ENOG4108KB2 LysR family Transcriptional regulator WP2W18E11_21170 ENOG4105CAU Arsenical resistance protein, ArsH WP2W18E11_21180 ENOG4105D6J arsenicaL-resistance protein WP2W18E11_21200 ENOG41082YX Transcriptional regulator, arsr family WP2W18E11_21230 ENOG4105CPN adenine deaminase WP2W18E11_21250 ENOG4105CBN LysR family transcriptional regulator WP2W18E11_21270 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease WP2W18E11_21300 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component WP2W18E11_21310 ENOG4108IY8 ABC, transporter WP2W18E11_21320 ENOG4106FTQ Taurine ABC transporter, periplasmic WP2W18E11_21340 ENOG4105C54 Major Facilitator superfamily WP2W18E11_21380 ENOG4105C4M (Ubiquinol oxidase) subunit I WP2W18E11_21390 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii WP2W18E11_21410 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WP2W18E11_21420 ENOG4108K70 Transcriptional regulator WP2W18E11_21450 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase WP2W18E11_21460 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase WP2W18E11_21490 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) WP2W18E11_21500 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase WP2W18E11_21550 ENOG41067MG lrgb family WP2W18E11_21560 ENOG4105VAW lrga family WP2W18E11_21570 ENOG4105CMU LysR family (Transcriptional regulator WP2W18E11_21580 ENOG4108SHQ Glutathione S-transferase WP2W18E11_21590 ENOG4105CYM Glutathione S-transferase WP2W18E11_21630 ENOG4105CBN LysR family transcriptional regulator WP2W18E11_21640 ENOG4105CHR reductase WP2W18E11_21660 ENOG4105D7W serine acetyltransferase WP2W18E11_21670 ENOG4105ESN nucleotide-binding protein WP2W18E11_21680 ENOG4105C9B Cysteine desulfurase WP2W18E11_21690 ENOG4105CCF Lysine exporter protein (Lyse ygga) WP2W18E11_21700 ENOG4105EXG Transcriptional regulator WP2W18E11_21720 ENOG4105CT1 (ABC) transporter WP2W18E11_21730 ENOG4107RP9 extracellular solute-binding protein, family 3 WP2W18E11_21750 ENOG4108HW4 amino acid AbC transporter WP2W18E11_21760 ENOG4105EAD ABC transporter WP2W18E11_21780 ENOG4107RTG Major Facilitator superfamily WP2W18E11_21790 ENOG4105EQ2 LysR family Transcriptional regulator WP2W18E11_21810 ENOG4105ENX hydrolase WP2W18E11_21820 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WP2W18E11_21830 ENOG4105BZU Histidine kinase WP2W18E11_21850 ENOG4105EW9 transcriptional regulator AsnC family WP2W18E11_21870 ENOG4105KT5 UmuD protein WP2W18E11_21910 ENOG4105CYX Short-chain dehydrogenase reductase Sdr WP2W18E11_22010 ENOG4105HEI LysR family (Transcriptional regulator WP2W18E11_22030 ENOG4105D2S major facilitator superfamily WP2W18E11_22060 ENOG4105CEY Amp-dependent synthetase and ligase WP2W18E11_22070 ENOG4105R8C Transcriptional regulator WP2W18E11_22080 ENOG4105C1G acyl-Coa dehydrogenase WP2W18E11_22090 ENOG4107QX3 carboxylase WP2W18E11_22100 ENOG4105E39 Enoyl-CoA hydratase WP2W18E11_22130 ENOG4105CC0 LysR family Transcriptional regulator WP2W18E11_22160 ENOG4105CSU acyl-Coa dehydrogenase WP2W18E11_22200 ENOG4107QNJ CoA-transferase subunit B WP2W18E11_22210 ENOG4107QP7 CoA-transferase subunit A WP2W18E11_22220 ENOG4107RGD Major Facilitator superfamily WP2W18E11_22230 ENOG4105C1G acyl-Coa dehydrogenase WP2W18E11_22240 ENOG4105E39 Enoyl-CoA hydratase WP2W18E11_22250 ENOG4105CHR reductase WP2W18E11_22260 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WP2W18E11_22270 ENOG4105CHU acetyl-coa acetyltransferase WP2W18E11_22290 ENOG4105EQ0 Major Facilitator superfamily WP2W18E11_22300 ENOG4105EA8 2-Nitropropane dioxygenase WP2W18E11_22310 ENOG4108UKI Enoyl-CoA hydratase WP2W18E11_22330 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WP2W18E11_22340 ENOG4105C1G acyl-Coa dehydrogenase WP2W18E11_22350 ENOG4107RGD Major Facilitator superfamily WP2W18E11_22360 ENOG4108KAZ Involved in phosphonate degradation (By similarity) WP2W18E11_22370 ENOG4107STF Involved in phosphonate degradation (By similarity) WP2W18E11_22390 ENOG4107RCV ABC transporter, permease WP2W18E11_22400 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WP2W18E11_22410 ENOG4105C4Y ABC transporter WP2W18E11_22440 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase WP2W18E11_22450 ENOG4107HP6 Transcriptional regulator WP2W18E11_22560 ENOG4107YAU phenylacetic acid degradation protein WP2W18E11_22570 ENOG4108Z0R Transferase WP2W18E11_22580 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein WP2W18E11_22590 ENOG4105DZS Phenylacetate-CoA ligase WP2W18E11_22600 ENOG4105CHU acetyl-coa acetyltransferase WP2W18E11_22610 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WP2W18E11_22620 ENOG4108UKI Enoyl-CoA hydratase WP2W18E11_22630 ENOG4105E39 Enoyl-CoA hydratase WP2W18E11_22640 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) WP2W18E11_22650 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit WP2W18E11_22660 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit WP2W18E11_22670 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit WP2W18E11_22680 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit WP2W18E11_22690 ENOG4105DXM phenylacetic acid degradation protein WP2W18E11_22700 ENOG4105EJQ L-serine dehydratase WP2W18E11_22740 ENOG4108Z4X TRANSCRIPTIONal WP2W18E11_22760 ENOG4105WPN DNA integration recombination invertion protein WP2W18E11_22770 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WP2W18E11_22800 ENOG4105DJ2 Major Facilitator Superfamily WP2W18E11_22810 ENOG4107Y2X deaminase WP2W18E11_22830 ENOG4108MP6 LysR family Transcriptional regulator WP2W18E11_22890 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit WP2W18E11_22910 ENOG4105EIY sodium-type flagellar protein motY WP2W18E11_23230 ENOG4108HW3 (ABC) transporter WP2W18E11_23250 ENOG4105MRR Transcriptional regulator (By similarity) WP2W18E11_23290 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF WP2W18E11_23300 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase WP2W18E11_23330 ENOG4105E2A Dehydrogenase WP2W18E11_23340 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) WP2W18E11_23410 ENOG4105CKT filamentous hemagglutinin WP2W18E11_23420 ENOG4105D5K Hemolysin activator protein WP2W18E11_23430 ENOG4107R4J Chloride channel WP2W18E11_23440 ENOG4108JIK carboxylase WP2W18E11_23480 ENOG4105C5A transporter WP2W18E11_23490 ENOG4108WAV Transcriptional regulator WP2W18E11_23510 ENOG4108WQI RNA Polymerase WP2W18E11_23530 ENOG4105E18 UPF0276 protein WP2W18E11_23650 ENOG4108IND Tetr family transcriptional regulator WP2W18E11_23690 ENOG4105BZU Histidine kinase WP2W18E11_23750 ENOG4105D2S major facilitator superfamily WP2W18E11_23760 ENOG4105CPW cytochrome b561 WP2W18E11_23770 ENOG4107VGR Catalase WP2W18E11_23800 ENOG4105CF7 AraC family transcriptional regulator WP2W18E11_23840 ENOG4105VEQ Cold shock protein WP2W18E11_23900 ENOG4105D5Q Arginine ornithine antiporter WP2W18E11_23910 ENOG4105CRN Aminoglycoside phosphotransferase WP2W18E11_23930 ENOG4108ZX5 transcriptional regulator WP2W18E11_23970 ENOG4108Z4U Ferredoxin WP2W18E11_24030 ENOG4105C42 Type I secretion membrane fusion protein (HlyD WP2W18E11_24050 ENOG4105DFG type I secretion outer membrane protein WP2W18E11_24060 ENOG4108IUZ ABC transporter WP2W18E11_24070 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA WP2W18E11_24100 ENOG4105C2X Arabinose 5-phosphate isomerase WP2W18E11_24220 ENOG4105CUY Mechanosensitive ion channel WP2W18E11_24300 ENOG4105R8C Transcriptional regulator WP2W18E11_24320 ENOG4105F2W methyltransferase WP2W18E11_24330 ENOG4105EW9 transcriptional regulator AsnC family WP2W18E11_24350 ENOG4105II7 pyrroline-5-carboxylate reductase WP2W18E11_24370 ENOG4105VEQ Cold shock protein WP2W18E11_24380 ENOG4105D1S lipid A biosynthesis WP2W18E11_24390 ENOG410829K Lysine exporter protein (Lyse ygga) WP2W18E11_24450 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) WP2W18E11_24570 ENOG4105EUV Phenol 2-monooxygenase WP2W18E11_24610 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein WP2W18E11_24630 ENOG4108KB2 LysR family Transcriptional regulator WP2W18E11_24640 ENOG4105FUY alpha subunit WP2W18E11_24650 ENOG4108UKV benzoate 1,2-dioxygenase WP2W18E11_24660 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein WP2W18E11_24670 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase WP2W18E11_24680 ENOG4105DKK Benzoate WP2W18E11_24690 ENOG4105D2S major facilitator superfamily WP2W18E11_24720 ENOG4105CQ7 ATP-dependent helicase WP2W18E11_24730 ENOG4105D3R alkyl hydroperoxide reductase WP2W18E11_24770 ENOG4108JU3 Alkyl hydroperoxide reductase WP2W18E11_24790 ENOG4108K3A Glutathione S-transferase WP2W18E11_24810 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) WP2W18E11_24820 ENOG4108TGY Glutathione S-transferase WP2W18E11_24840 ENOG4108ZG0 Ompa motb domain protein WP2W18E11_24850 ENOG4105CD3 dihydroorotase WP2W18E11_24910 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit WP2W18E11_24940 ENOG4108UKZ OsmC family WP2W18E11_24950 ENOG4107RYR Transcriptional regulator, Crp Fnr family WP2W18E11_24960 ENOG4105CPC Aldo Keto reductase WP2W18E11_24990 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis WP2W18E11_25010 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase WP2W18E11_25030 ENOG4105CFH Aspartokinase WP2W18E11_25050 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) WP2W18E11_25070 ENOG4105CPW cytochrome b561 WP2W18E11_25080 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) WP2W18E11_25090 ENOG4105C7N Xanthine uracil vitamin C permease WP2W18E11_25150 ENOG4105F95 Monooxygenase WP2W18E11_25160 ENOG4105JQZ Methyltransferase WP2W18E11_25170 ENOG4105EJC lysr family transcriptional regulator WP2W18E11_25200 ENOG4107GFK fumarate WP2W18E11_25220 ENOG4107RN6 Monooxygenase WP2W18E11_25260 ENOG4105DDY UPF0142 protein ycaO WP2W18E11_25270 ENOG4105EPF Outer membrane porin WP2W18E11_25280 ENOG4105D2S major facilitator superfamily WP2W18E11_25290 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) WP2W18E11_25300 ENOG4105E6M Sulphatase-modifying factor protein WP2W18E11_25330 ENOG4105E3J oxidoreductase WP2W18E11_25360 ENOG4108SC4 )-transporter WP2W18E11_25370 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase WP2W18E11_25400 ENOG4105C1G acyl-Coa dehydrogenase WP2W18E11_25410 ENOG4105EPF Outer membrane porin WP2W18E11_25420 ENOG4105NI3 Protein of unknown function (DUF3237) WP2W18E11_25450 ENOG4105JXH GntR family transcriptional regulator WP2W18E11_25460 ENOG4105CZJ Aldehyde dehydrogenase WP2W18E11_25480 ENOG4105EQX glucarate dehydratase WP2W18E11_25490 ENOG4105DJB Major Facilitator Superfamily WP2W18E11_25500 ENOG4105CTX dehydratase WP2W18E11_25510 ENOG4105DJP Membrane WP2W18E11_25520 ENOG4108ZX5 transcriptional regulator WP2W18E11_25530 ENOG4107RGH Aldehyde dehydrogenase WP2W18E11_25550 ENOG4105C85 amino acid WP2W18E11_25590 ENOG4105C26 Dehydrogenase WP2W18E11_25630 ENOG4105CUB amino acid WP2W18E11_25650 ENOG4105C85 amino acid WP2W18E11_25670 ENOG4107Y60 (LipO)protein WP2W18E11_25690 ENOG4106B0W Curli production assembly transport component CsgG WP2W18E11_25720 ENOG4108M3P Membrane WP2W18E11_25800 ENOG4105CAH Chromate WP2W18E11_25830 ENOG4105EUZ Beta-lactamase domain protein WP2W18E11_25860 ENOG4105PGM cation diffusion facilitator family transporter WP2W18E11_25900 ENOG4107Y80 Major Facilitator superfamily WP2W18E11_26110 ENOG4105DFP Integrase WP2W18E11_26130 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WP2W18E11_26170 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) WP2W18E11_26200 ENOG4108JQ5 ABC transporter WP2W18E11_26210 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component WP2W18E11_26220 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component WP2W18E11_26230 ENOG4105E43 Extracellular solute-binding protein, family 5 WP2W18E11_26240 ENOG4105E9H Lytic Murein transglycosylase WP2W18E11_26250 ENOG4107RZZ dna polymerase iii epsilon subunit WP2W18E11_26270 ENOG4105E09 nadh pyrophosphatase WP2W18E11_26290 ENOG4105W4M Transport-associated protein WP2W18E11_26310 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) WP2W18E11_26340 ENOG4108ZUB Lysine exporter protein (Lyse ygga) WP2W18E11_26360 ENOG4105W1Y Transcriptional regulator WP2W18E11_26380 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family WP2W18E11_26390 ENOG4105D0A hydroxylase WP2W18E11_26400 ENOG4107RAQ aminopeptidase WP2W18E11_26470 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase WP2W18E11_26500 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b WP2W18E11_26520 ENOG4105D82 Glutamate dehydrogenase WP2W18E11_26530 ENOG4108R3D Electron transport complex WP2W18E11_26540 ENOG4105CSM endonuclease III WP2W18E11_26590 ENOG4105CJN penicillin-binding protein WP2W18E11_26600 ENOG4106H78 methyltransferase WP2W18E11_26630 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) WP2W18E11_26650 ENOG4105CQM Urea amidohydrolase subunit alpha WP2W18E11_26700 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion WP2W18E11_26710 ENOG4107RET Isocitrate lyase WP2W18E11_26730 ENOG4105C37 (CBS) domain WP2W18E11_26740 ENOG4105D4T Citrate transporter WP2W18E11_26770 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) WP2W18E11_26800 ENOG4108MRJ WP2W18E11_26840 ENOG4105VCQ rubredoxin WP2W18E11_26850 ENOG4107QZF nitrite reductase NADPH large subunit WP2W18E11_26860 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) WP2W18E11_26870 ENOG4105C5Q Transcriptional regulator WP2W18E11_26910 ENOG4107U91 Rhomboid family WP2W18E11_26920 ENOG4105CV6 ABC transporter, permease WP2W18E11_26930 ENOG4108I0Y (ABC) transporter WP2W18E11_26940 ENOG4108UJV acyl-CoA thioesterase i WP2W18E11_26980 ENOG4107RNH Outer membrane receptor FepA WP2W18E11_27010 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) WP2W18E11_27020 ENOG4105E6M Sulphatase-modifying factor protein WP2W18E11_27060 ENOG4105CJ3 phosphate transporter WP2W18E11_27070 ENOG4105C3R Methionine synthase WP2W18E11_27140 ENOG4105CSP Major Facilitator Superfamily WP2W18E11_27160 ENOG4108PZW LysR family Transcriptional regulator WP2W18E11_27200 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) WP2W18E11_27210 ENOG4105EU0 Major facilitator Superfamily WP2W18E11_27220 ENOG4108R6W Transcriptional regulator, ARAC family WP2W18E11_27230 ENOG4105CSV Glutaminase WP2W18E11_27240 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) WP2W18E11_27250 ENOG4105CSH Transporter WP2W18E11_27270 ENOG4105C7K acetolactate synthase WP2W18E11_27300 ENOG4105CHR reductase WP2W18E11_27310 ENOG4108MXF Alpha Beta Hydrolase WP2W18E11_27330 ENOG4105DJB Major Facilitator Superfamily WP2W18E11_27360 ENOG4105CHR reductase WP2W18E11_27400 ENOG41069M3 Transcriptional regulator WP2W18E11_27430 ENOG4105E9F Enoyl-CoA hydratase WP2W18E11_27450 ENOG4105CND Glycosyl transferase, family 2 WP2W18E11_27460 ENOG4107BJW polysaccharide deacetylase WP2W18E11_27480 ENOG4108VWS Yaeq family WP2W18E11_27500 ENOG4105CKI cobalamin synthesis protein WP2W18E11_27520 ENOG4108S4H thioesterase Superfamily protein WP2W18E11_27540 ENOG4105C94 Transporter WP2W18E11_27550 ENOG4105C94 Transporter WP2W18E11_27560 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) WP2W18E11_27610 ENOG4107QK5 Homocysteine s-methyltransferase WP2W18E11_27620 ENOG4105D5Q Arginine ornithine antiporter WP2W18E11_27670 ENOG4108YNN Heme oxygenase WP2W18E11_27730 ENOG4108SF5 RNA Polymerase WP2W18E11_27750 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WP2W18E11_27760 ENOG4105C54 Major Facilitator superfamily WP2W18E11_27980 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WP2W18E11_28150 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) WP2W18E11_28480 ENOG4105VTN Protein of unknown function (DUF1311) WP2W18E11_28810 ENOG41083X2 DNA polymerase III, epsilon subunit WP2W18E11_28940 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) WP2W18E11_28950 ENOG4105C0R drug resistance transporter emrb qaca subfamily WP2W18E11_28960 ENOG4105CW7 secretion protein, HlyD family WP2W18E11_28970 ENOG4108VUY thioesterase Superfamily protein WP2W18E11_28980 ENOG4105D52 delta-aminolevulinic acid dehydratase WP2W18E11_28990 ENOG4105MWK D-amino acid dehydrogenase, small subunit WP2W18E11_29000 ENOG4105ECP epimerase WP2W18E11_29040 ENOG4107RH8 nuclease SbcCD subunit D WP2W18E11_29050 ENOG4105EYH Exonuclease WP2W18E11_29060 ENOG4105DFA alanine racemase domain protein WP2W18E11_29070 ENOG4105CZX twitching motility protein WP2W18E11_29080 ENOG4105CZX twitching motility protein WP2W18E11_29090 ENOG41090R7 Ferric uptake WP2W18E11_29110 ENOG4105VDB UPF0125 protein WP2W18E11_29140 ENOG4105E7A Glutamine amidotransferase WP2W18E11_29170 ENOG4107QKV phosphomannomutase WP2W18E11_29190 ENOG4105C4R Atp-dependent dna helicase WP2W18E11_29210 ENOG4108ZG0 Ompa motb domain protein WP2W18E11_29220 ENOG4106HNH Acyl-transferase WP2W18E11_29250 ENOG4107QMS site-determining protein WP2W18E11_29290 ENOG4105CCF Lysine exporter protein (Lyse ygga) WP2W18E11_29300 ENOG4105CNU cell division protein FtsK WP2W18E11_29310 ENOG4105C3M thioredoxin reductase WP2W18E11_29320 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) WP2W18E11_29340 ENOG4105KEG ribosomal-protein-alanine acetyltransferase WP2W18E11_29370 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) WP2W18E11_29380 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) WP2W18E11_29400 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) WP2W18E11_29430 ENOG4108YXA Membrane WP2W18E11_29450 ENOG4105C4K Nad synthetase WP2W18E11_29470 ENOG4105E3J oxidoreductase WP2W18E11_29480 ENOG4105C26 Dehydrogenase WP2W18E11_29490 ENOG4105DVW rieske (2Fe-2S) WP2W18E11_29510 ENOG4105C94 Transporter WP2W18E11_29520 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) WP2W18E11_29530 ENOG4105EJC lysr family transcriptional regulator WP2W18E11_29550 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding WP2W18E11_29590 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase WP2W18E11_29600 ENOG4105C34 Pseudouridine synthase WP2W18E11_29610 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane WP2W18E11_29620 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) WP2W18E11_29650 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) WP2W18E11_29670 ENOG4105C5T Phosphoribosyl pyrophosphate synthase WP2W18E11_29730 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) WP2W18E11_29750 ENOG4105DWF phosphomethylpyrimidine kinase WP2W18E11_29760 ENOG4109066 lysm domain bon superfamily protein WP2W18E11_29780 ENOG4105CHR reductase WP2W18E11_29790 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase WP2W18E11_29810 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein WP2W18E11_29820 ENOG4108BPE -transporting atpase WP2W18E11_29830 ENOG4107RTD sua5 ycio yrdc ywlc family protein WP2W18E11_29840 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) WP2W18E11_29850 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) WP2W18E11_29860 ENOG4105FE9 pseudouridine synthase WP2W18E11_29880 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) WP2W18E11_29890 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) WP2W18E11_29910 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) WP2W18E11_29930 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase WP2W18E11_29940 ENOG4106UW1 Major Facilitator superfamily WP2W18E11_29980 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) WP2W18E11_30000 ENOG4105HF0 Membrane WP2W18E11_30030 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY WP2W18E11_30050 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) WP2W18E11_30150 ENOG4105D1F ATP-binding protein WP2W18E11_30170 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) WP2W18E11_30240 ENOG4105K6H D-cysteine desulfhydrase WP2W18E11_30250 ENOG4105CBX hi0933 family WP2W18E11_30300 ENOG4105DP0 ferredoxin-NADP reductase WP2W18E11_30310 ENOG4105DUM transcriptional regulator, lysR family WP2W18E11_30350 ENOG4105C8S subunit m WP2W18E11_30360 ENOG4105D65 subunit l WP2W18E11_30380 ENOG4107UFS subunit j WP2W18E11_30410 ENOG4108IEH NADH dehydrogenase subunit g WP2W18E11_30420 ENOG4107QIZ NADH dehydrogenase WP2W18E11_30430 ENOG4105GKE subunit e WP2W18E11_30470 ENOG4105BZU Histidine kinase WP2W18E11_30490 ENOG4105E0F Histidine kinase WP2W18E11_30500 ENOG4107EXC regulatoR WP2W18E11_30510 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WP2W18E11_30530 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WP2W18E11_30620 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) WP2W18E11_30650 ENOG4105ETT transcriptional Regulator, LysR family WP2W18E11_30690 ENOG4105CH2 amidohydrolase WP2W18E11_30750 ENOG4106P55 Transcriptional regulator WP2W18E11_30780 ENOG4106P55 Transcriptional regulator WP2W18E11_30790 ENOG4107EFR Flavocytochrome c WP2W18E11_30850 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WP2W18E11_30860 ENOG4107RGD Major Facilitator superfamily WP2W18E11_30870 ENOG4105C1G acyl-Coa dehydrogenase WP2W18E11_30880 ENOG4105ETT transcriptional Regulator, LysR family WP2W18E11_30900 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) WP2W18E11_30910 ENOG4107R08 Integrase WP2W18E11_30920 ENOG4105UMD exodeoxyribonuclease X WP2W18E11_31290 ENOG4108E1C hydrolase WP2W18E11_31380 ENOG4105ED4 portal protein WP2W18E11_31400 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) WP2W18E11_31410 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) WP2W18E11_31420 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) WP2W18E11_31460 ENOG4105E3B Multicopper oxidase WP2W18E11_31480 ENOG4108HCJ Hydrolase WP2W18E11_31490 ENOG4105DJV ribulose-phosphate 3-epimerase WP2W18E11_31540 ENOG41072GX Peptidase M22 Glycoprotease WP2W18E11_31550 ENOG4108Z0R Transferase WP2W18E11_31640 ENOG4105CRQ synthase (Component I) WP2W18E11_31660 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) WP2W18E11_31670 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) WP2W18E11_31680 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) WP2W18E11_31770 ENOG4105K56 Transcriptional regulator WP2W18E11_31780 ENOG4108ZHJ Organic hydroperoxide resistance protein WP2W18E11_31790 ENOG4107QHF type ii secretion system protein e WP2W18E11_31830 ENOG4105C2M dna polymerase I WP2W18E11_31840 ENOG4108VIA integral membrane protein WP2W18E11_31850 ENOG4105II7 pyrroline-5-carboxylate reductase WP2W18E11_31860 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) WP2W18E11_31880 ENOG4105C9X ppx gppa phosphatase WP2W18E11_31900 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) WP2W18E11_31930 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) WP2W18E11_31990 ENOG41082NX 50s ribosomal protein l35 WP2W18E11_32010 ENOG4105W39 Membrane WP2W18E11_32020 ENOG4105CYM Glutathione S-transferase WP2W18E11_32050 ENOG4105CEY Amp-dependent synthetase and ligase WP2W18E11_32060 ENOG4105N42 UPF0307 protein WP2W18E11_32070 ENOG41080Z8 PHOSPHOCARRIER protein WP2W18E11_32110 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase WP2W18E11_32120 ENOG4105DJ0 Poly(A) Polymerase WP2W18E11_32130 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein WP2W18E11_32140 ENOG4105DXN mazG family WP2W18E11_32150 ENOG4105EMU Dehydrogenase WP2W18E11_32160 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) WP2W18E11_32190 ENOG4105C6T cysteine synthase WP2W18E11_32200 ENOG4105BZU Histidine kinase WP2W18E11_32210 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase WP2W18E11_32220 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase WP2W18E11_32230 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) WP2W18E11_32260 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) WP2W18E11_32270 ENOG4105W8H transhydrogenase (subunit alpha WP2W18E11_32280 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) WP2W18E11_32290 ENOG4106UX7 integral membrane protein WP2W18E11_32390 ENOG4105H3G oxidoreductase WP2W18E11_32400 ENOG4105C3M thioredoxin reductase WP2W18E11_32410 ENOG4105CAU Arsenical resistance protein, ArsH WP2W18E11_32420 ENOG4105D6J arsenicaL-resistance protein WP2W18E11_32440 ENOG4105KBH arsR family transcriptional regulator WP2W18E11_32490 ENOG4105CE1 Ferrous iron transport protein b WP2W18E11_32510 ENOG4108IJF Heavy metal efflux pump, CzcA WP2W18E11_32520 ENOG4108IJF Heavy metal efflux pump, CzcA WP2W18E11_32570 ENOG4105E3B Multicopper oxidase WP2W18E11_32600 ENOG4105GR3 Histidine kinase WP2W18E11_32790 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) WP2W18E11_32820 ENOG4107RSM transcriptional regulator WP2W18E11_32830 ENOG4105CUZ uba thif-type nad fad binding protein WP2W18E11_32850 ENOG4107QM5 aconitate hydratase WP2W18E11_32860 ENOG4105F8V Hydrolase, tatD family WP2W18E11_32890 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) WP2W18E11_32920 ENOG4105BZU Histidine kinase WP2W18E11_32930 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase WP2W18E11_32940 ENOG4108ZP8 Acetolactate synthase small subunit WP2W18E11_32950 ENOG4105C7K acetolactate synthase WP2W18E11_32990 ENOG4105DJY efflux transporter, rnd family, mfp subunit WP2W18E11_33000 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) WP2W18E11_33010 ENOG4105ENJ RND efflux system, outer membrane lipoprotein WP2W18E11_33020 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH WP2W18E11_33040 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) WP2W18E11_33050 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) WP2W18E11_33070 ENOG4105VW4 glutaredoxin 3 WP2W18E11_33110 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) WP2W18E11_33150 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) WP2W18E11_33190 ENOG4105WVQ Fe-S assembly protein IscX WP2W18E11_33220 ENOG4105CN1 protease WP2W18E11_33250 ENOG4106HB6 Alpha beta hydrolase WP2W18E11_33270 ENOG4105C26 Dehydrogenase WP2W18E11_33280 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family WP2W18E11_33290 ENOG4105C6Z Gluconate WP2W18E11_33300 ENOG4108UHU Aldolase WP2W18E11_33310 ENOG4105C01 Dihydroxy-acid dehydratase WP2W18E11_33320 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) WP2W18E11_33330 ENOG4108DNC Involved in acetate metabolism (By similarity) WP2W18E11_33340 ENOG4107GFK fumarate WP2W18E11_33380 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) WP2W18E11_33400 ENOG4108ESX Receptor WP2W18E11_33420 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) WP2W18E11_33440 ENOG4105DWV Homoserine O-trans-acetylase WP2W18E11_33640 ENOG4105CIY formyltetrahydrofolate deformylase WP2W18E11_33660 ENOG4107RGH Aldehyde dehydrogenase WP2W18E11_33690 ENOG4105CKD glutathione-regulated potassium-efflux system protein WP2W18E11_33730 ENOG4105VFU Rna-binding protein WP2W18E11_33740 ENOG4105C4R Atp-dependent dna helicase WP2W18E11_33770 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) WP2W18E11_33790 ENOG4105KVH Transcriptional regulator WP2W18E11_33810 ENOG41069P5 Protein slyX homolog WP2W18E11_33820 ENOG4105C5H ABC transporter WP2W18E11_33840 ENOG4105D1S lipid A biosynthesis WP2W18E11_33860 ENOG4105CK2 sodium dicarboxylate symporter WP2W18E11_33970 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) WP2W18E11_34070 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase WP2W18E11_34100 ENOG4108W5M transcriptional regulator WP2W18E11_34130 ENOG4105D29 Helix-turn-helix type 11 domain protein WP2W18E11_34140 ENOG4107XGZ Hydrolase WP2W18E11_34150 ENOG4105EI2 Pseudouridine synthase WP2W18E11_34160 ENOG4105C03 ribonuclease WP2W18E11_34170 ENOG4105J5T Amp-dependent synthetase and ligase WP2W18E11_34180 ENOG4105CBN LysR family transcriptional regulator WP2W18E11_34200 ENOG4105CSA Coproporphyrinogen iii oxidase WP2W18E11_34220 ENOG4107QI1 Mate efflux family protein WP2W18E11_34240 ENOG4107T8P acyl-Coa dehydrogenase WP2W18E11_34300 ENOG4105BZ8 glutamate synthase WP2W18E11_34320 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) WP2W18E11_34330 ENOG4105C5X domain protein WP2W18E11_34360 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) WP2W18E11_34380 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase WP2W18E11_34400 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) WP2W18E11_34410 ENOG4108JU5 Magnesium and cobalt efflux protein WP2W18E11_34420 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) WP2W18E11_34430 ENOG4108Z7R Chaperone CsaA WP2W18E11_34450 ENOG4108VAU general secretion pathway protein G WP2W18E11_34460 ENOG4105D7Q type ii secretion system WP2W18E11_34470 ENOG4105C25 Primosomal protein n' WP2W18E11_34490 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) WP2W18E11_34510 ENOG4105DVC DnaJ domain protein WP2W18E11_34520 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) WP2W18E11_34530 ENOG4107QUT magnesium and cobalt transport protein CorA WP2W18E11_34540 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) WP2W18E11_34570 ENOG4107QYX exodeoxyribonuclease v alpha WP2W18E11_34580 ENOG4107QKA exodeoxyribonuclease V beta WP2W18E11_34590 ENOG4105DSY exodeoxyribonuclease V, gamma WP2W18E11_34610 ENOG4105CSR polyphosphate kinase 2 WP2W18E11_34630 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WP2W18E11_34650 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) WP2W18E11_34670 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase WP2W18E11_34680 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase WP2W18E11_34710 ENOG4105D65 subunit l WP2W18E11_34720 ENOG4108ZE9 Monovalent cation H antiporter subunit C WP2W18E11_34730 ENOG4107R4Z monovalent cation h antiporter subunit d WP2W18E11_34740 ENOG4105SC1 monovalent cation H antiporter subunit E WP2W18E11_34750 ENOG4105W4C monovalent cation H antiporter subunit F WP2W18E11_34760 ENOG4105KJM monovalent cation h antiporter subunit g WP2W18E11_34770 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) WP2W18E11_34790 ENOG4105CHV Transcription elongation factor NusA WP2W18E11_34810 ENOG4107EJC Preprotein translocase subunit SecG WP2W18E11_34830 ENOG4107QHF type ii secretion system protein e WP2W18E11_34860 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) WP2W18E11_34880 ENOG4105C2N RNA methyltransferase TrmH family group 3 WP2W18E11_34910 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) WP2W18E11_34930 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) WP2W18E11_34990 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) WP2W18E11_35000 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase WP2W18E11_35110 ENOG4108Z6Z Transcriptional regulator WP2W18E11_35130 ENOG4107ZXU DSBA oxidoreductase WP2W18E11_35160 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) WP2W18E11_35190 ENOG4105D3Y Na H antiporter WP2W18E11_35300 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) WP2W18E11_35310 ENOG4105PM1 preprotein translocase subunit SecE WP2W18E11_35320 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) WP2W18E11_35340 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) WP2W18E11_35350 ENOG4105TV9 FHA Domain-Containing protein WP2W18E11_35360 ENOG4105GVR general secretion pathway protein D WP2W18E11_35390 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS WP2W18E11_35440 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) WP2W18E11_35450 ENOG4108NEV two component transcriptional regulator, LytTR family WP2W18E11_35460 ENOG4108HRK Histidine kinase WP2W18E11_35490 ENOG4108UTW Plays a role in the regulation of phosphate uptake WP2W18E11_35500 ENOG4105DFG type I secretion outer membrane protein WP2W18E11_35510 ENOG4108RNG Permease of the drug metabolite transporter WP2W18E11_35550 ENOG41087AY ADP-Ribose pyrophosphatase WP2W18E11_35560 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) WP2W18E11_35580 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) WP2W18E11_35590 ENOG4105CNI cell division protein FtsW WP2W18E11_35620 ENOG4105CE1 Ferrous iron transport protein b WP2W18E11_35640 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WP2W18E11_35650 ENOG4105T95 Thiol disulfide interChange protein WP2W18E11_35660 ENOG4105D6E homoserine dehydrogenase WP2W18E11_35680 ENOG41061WM D-Alanyl-D-Alanine WP2W18E11_35700 ENOG4107TUY Histidine kinase WP2W18E11_35710 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WP2W18E11_35720 ENOG4105CN1 protease WP2W18E11_35730 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) WP2W18E11_35740 ENOG4108K5H permease YjgP YjgQ family protein WP2W18E11_35820 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) WP2W18E11_35840 ENOG4105BZU Histidine kinase WP2W18E11_35870 ENOG4105C0P Mg chelatase subunit ChlI WP2W18E11_35880 ENOG4108YYH Nadph-dependent fmn reductase WP2W18E11_35890 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WP2W18E11_35900 ENOG4105FB2 class II Aldolase WP2W18E11_35910 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WP2W18E11_35940 ENOG4105EPF Outer membrane porin WP2W18E11_35950 ENOG4105F0N pyrophosphate phospho-hydrolase WP2W18E11_35980 ENOG4105CEY Amp-dependent synthetase and ligase WP2W18E11_35990 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WP2W18E11_36000 ENOG41079KZ Major Facilitator Superfamily WP2W18E11_36010 ENOG4105EN6 Membrane WP2W18E11_36030 ENOG4105EE5 Membrane protein terC WP2W18E11_36040 ENOG4108URH decarboxylase WP2W18E11_36050 ENOG4105C0R drug resistance transporter emrb qaca subfamily WP2W18E11_36070 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WP2W18E11_36100 ENOG4105CCT upf0313 protein WP2W18E11_36140 ENOG4105CS1 NAD(P)H quinone oxidoreductase WP2W18E11_36170 ENOG4105C6T cysteine synthase WP2W18E11_36180 ENOG4105Y7M Transcriptional regulator, TetR family WP2W18E11_36250 ENOG4105C79 DNA protecting protein DprA WP2W18E11_36280 ENOG4108IND Tetr family transcriptional regulator WP2W18E11_36290 ENOG4107RTG Major Facilitator superfamily WP2W18E11_36310 ENOG4108V06 Glutathione peroxidase WP2W18E11_36340 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) WP2W18E11_36360 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) WP2W18E11_36440 ENOG4105FDK ABC transporter WP2W18E11_36450 ENOG4105FAV ABC, transporter WP2W18E11_36460 ENOG410829K Lysine exporter protein (Lyse ygga) WP2W18E11_36470 ENOG4105EZR dyp-type peroxidase family protein WP2W18E11_36480 ENOG4107R1I NAD-dependent malic enzyme WP2W18E11_36530 ENOG4105EUB pirin domain protein WP2W18E11_36570 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) WP2W18E11_36580 ENOG4106MP8 UPF0754 membrane protein WP2W18E11_36590 ENOG4108VBZ doxx family WP2W18E11_36600 ENOG4105DQR SNARE associated Golgi WP2W18E11_36630 ENOG4107QJE Chromosome Partitioning Protein WP2W18E11_36650 ENOG4107PSF BolA-like protein WP2W18E11_36720 ENOG4105C1G acyl-Coa dehydrogenase WP2W18E11_36730 ENOG4107RCI amp-dependent synthetase and ligase WP2W18E11_36770 ENOG4105CSH Transporter WP2W18E11_36780 ENOG4105E39 Enoyl-CoA hydratase WP2W18E11_36790 ENOG4105E39 Enoyl-CoA hydratase WP2W18E11_36800 ENOG4105C1G acyl-Coa dehydrogenase WP2W18E11_36820 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase WP2W18E11_36830 ENOG4105C26 Dehydrogenase WP2W18E11_36850 ENOG4105C85 amino acid WP2W18E11_36860 ENOG4105C85 amino acid WP2W18E11_36870 ENOG4105M4H endoribonuclease L-psp WP2W18E11_36900 ENOG4105EW9 transcriptional regulator AsnC family WP2W18E11_36950 ENOG4105D3G Pseudouridine synthase WP2W18E11_37070 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) WP2W18E11_37150 ENOG4108I0Z Aconitate hydratase WP2W18E11_37160 ENOG4105BZN citrate synthase WP2W18E11_37170 ENOG4105CR4 methylisocitrate lyase WP2W18E11_37180 ENOG4105DRR Transcriptional regulator, GntR family WP2W18E11_37190 ENOG4105CGF Aromatic amino acid aminotransferase WP2W18E11_37200 ENOG4105CXG d-lactate dehydrogenase WP2W18E11_37220 ENOG41073TP transcriptional regulator WP2W18E11_37230 ENOG4105DAA L-lactate WP2W18E11_37240 ENOG4107QKV phosphomannomutase WP2W18E11_37260 ENOG4105C6Y Udp-glucose 6-dehydrogenase WP2W18E11_37270 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase WP2W18E11_37280 ENOG4105D3Q Sugar transferase WP2W18E11_37300 ENOG4105H63 Glycosyl transferase, family 2 WP2W18E11_37330 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase WP2W18E11_37350 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase WP2W18E11_37360 ENOG4105C1B dTDP-glucose 4-6-dehydratase WP2W18E11_37370 ENOG4105C6Y Udp-glucose 6-dehydrogenase WP2W18E11_37400 ENOG4107QQG Dehydrogenase WP2W18E11_37410 ENOG4105DAY polysaccharide export protein WP2W18E11_37430 ENOG4105D75 Capsular exopolysaccharide family WP2W18E11_37440 ENOG4108V1T peptidylprolyl cis-trans isomerase WP2W18E11_37450 ENOG4108V1T peptidylprolyl cis-trans isomerase WP2W18E11_37460 ENOG4105CJR Integral membrane protein (MviN WP2W18E11_37470 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase WP2W18E11_37480 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase WP2W18E11_37500 ENOG4105HSS phospholipase C WP2W18E11_37550 ENOG41062JF Transcriptional regulator WP2W18E11_37560 ENOG4108Z33 Thiol disulfide Interchange Protein WP2W18E11_37580 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) WP2W18E11_37590 ENOG4105UBK short-chain dehydrogenase reductase WP2W18E11_37620 ENOG4107QZM n-acetylglutamate synthase WP2W18E11_37630 ENOG4105GVF (ABC) transporter WP2W18E11_37640 ENOG4105GVF (ABC) transporter WP2W18E11_37650 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) WP2W18E11_37660 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component WP2W18E11_37670 ENOG4108VM9 ABC, transporter WP2W18E11_37680 ENOG4108R86 Transcriptional regulator WP2W18E11_37690 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) WP2W18E11_37710 ENOG4105DTN riboflavin biosynthesis protein ribF WP2W18E11_37720 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) WP2W18E11_37740 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase WP2W18E11_37770 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) WP2W18E11_37880 ENOG4105CVE Lytic murein transglycosylase WP2W18E11_37890 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit WP2W18E11_37900 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) WP2W18E11_37920 ENOG4105DFU Cell wall formation (By similarity) WP2W18E11_37940 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase WP2W18E11_37950 ENOG4105DU1 integral membrane protein, terc WP2W18E11_37970 ENOG4106032 Glutathionylspermidine synthase WP2W18E11_37990 ENOG4107QUY Guanine deaminase WP2W18E11_38000 ENOG4108UGV hypoxanthine phosphoribosyltransferase WP2W18E11_38020 ENOG4105T95 Thiol disulfide interChange protein WP2W18E11_38030 ENOG4105PGM cation diffusion facilitator family transporter WP2W18E11_38060 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins WP2W18E11_P10140 ENOG4105EMU Dehydrogenase WP2W18E11_P10150 ENOG4105EJC lysr family transcriptional regulator WP2W18E11_P10160 ENOG4107QPD alcohol dehydrogenase WP2W18E11_P10190 ENOG4105RPH Inner membrane protein YddG WP2W18E11_P10200 ENOG4105CSH Transporter WP2W18E11_P10220 ENOG4105ECQ AraC Family Transcriptional Regulator WP2W18E11_P10250 ENOG4105C4W S-formylglutathione hydrolase WP2W18E11_P10270 ENOG4108I6A alcohol dehydrogenase WP2W18E11_P10290 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WP2W18E11_P10310 ENOG4108WUH Transcriptional regulator, TetR family WP2W18E11_P10320 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein WP2W18E11_P10340 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium WP2W18E11_P10430 ENOG4108R6W Transcriptional regulator, ARAC family WP2W18E11_P10440 ENOG4107Z7P Ferredoxin WP2W18E11_P10490 ENOG4108RZE Tetr family transcriptional regulator WP2W18E11_P10560 ENOG4105E4P ATPase (AAA WP2W18E11_P10610 ENOG4105MP0 transposase WP2W18E11_P10620 ENOG4108BUD transposase WP2W18E11_P10640 ENOG4105CPW cytochrome b561 WP2W18E11_P10660 ENOG4108BUD transposase WP2W18E11_P10800 ENOG4105MZU cell filamentation protein WP2W18E11_P10870 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)