locus-tag	class	description
WP2W18E11_00020	COG0592	DNA-directed DNA polymerase activity
WP2W18E11_00040	COG0187	DNA topoisomerase II activity
WP2W18E11_00070	COG0488	(ABC) transporter
WP2W18E11_00120	COG0596	Alpha beta hydrolase
WP2W18E11_00130	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
WP2W18E11_00140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP2W18E11_00150	COG0625	glutathione transferase activity
WP2W18E11_00170	COG0733	neurotransmitter:sodium symporter activity
WP2W18E11_00250	COG2233	PERMEase
WP2W18E11_00280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18E11_00350	COG2814	Major facilitator Superfamily
WP2W18E11_00360	COG0656	L-ascorbic acid biosynthetic process
WP2W18E11_00370	COG0583	DNA-binding transcription factor activity
WP2W18E11_00390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP2W18E11_00400	COG1064	alcohol dehydrogenase
WP2W18E11_00410	COG2818	Glycosylase
WP2W18E11_00440	COG1194	a g-specific adenine glycosylase
WP2W18E11_00470	COG5487	UPF0391 membrane protein
WP2W18E11_00480	COG2983	Belongs to the UPF0260 family
WP2W18E11_00490	COG2133	pyrroloquinoline quinone binding
WP2W18E11_00500	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WP2W18E11_00510	COG2116	formate transmembrane transporter activity
WP2W18E11_00550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP2W18E11_00560	COG1335	isochorismatase
WP2W18E11_00570	COG0385	Bile acid
WP2W18E11_00580	COG0534	Mate efflux family protein
WP2W18E11_00590	COG1683	Conserved Protein
WP2W18E11_00620	COG0346	lactoylglutathione lyase activity
WP2W18E11_00630	COG0625	glutathione transferase activity
WP2W18E11_00650	COG1113	amino acid transport
WP2W18E11_00670	COG0523	cobalamin synthesis protein
WP2W18E11_00690	COG2188	Transcriptional regulator
WP2W18E11_00750	COG0010	Belongs to the arginase family
WP2W18E11_00770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP2W18E11_00850	COG0546	phosphoglycolate phosphatase activity
WP2W18E11_00860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WP2W18E11_00890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WP2W18E11_00910	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WP2W18E11_00920	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WP2W18E11_01120	COG0534	Mate efflux family protein
WP2W18E11_01130	COG0436	Aminotransferase
WP2W18E11_01140	COG2733	membrane
WP2W18E11_01170	COG2918	glutathione biosynthetic process
WP2W18E11_01190	COG3501	Rhs element vgr protein
WP2W18E11_01260	COG3150	esterase
WP2W18E11_01280	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
WP2W18E11_01300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP2W18E11_01320	COG2233	PERMEase
WP2W18E11_01330	COG2351	hydroxyisourate hydrolase activity
WP2W18E11_01400	COG3706	GGDEF domain
WP2W18E11_01430	COG1393	Belongs to the ArsC family
WP2W18E11_01440	COG0708	Exodeoxyribonuclease III
WP2W18E11_01500	COG0189	ligase activity
WP2W18E11_01540	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WP2W18E11_01560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WP2W18E11_01590	COG4942	peptidase
WP2W18E11_01610	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP2W18E11_01630	COG2119	membrane
WP2W18E11_01640	COG4774	siderophore transport
WP2W18E11_01650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WP2W18E11_01650	COG0426	domain, Protein
WP2W18E11_01690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WP2W18E11_01730	COG1902	pentaerythritol trinitrate reductase activity
WP2W18E11_01740	COG1519	Transferase
WP2W18E11_01750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WP2W18E11_01760	COG0668	transmembrane transport
WP2W18E11_01780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP2W18E11_01790	COG1335	isochorismatase
WP2W18E11_01800	COG1522	sequence-specific DNA binding
WP2W18E11_01850	COG2205	protein histidine kinase activity
WP2W18E11_01850	COG2198	Histidine kinase
WP2W18E11_01850	COG0784	Response regulator, receiver
WP2W18E11_01860	COG3162	membrane
WP2W18E11_01870	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP2W18E11_01890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WP2W18E11_01910	COG3706	GGDEF domain
WP2W18E11_01930	COG1309	transcriptional regulator
WP2W18E11_01970	COG0300	oxidoreductase activity
WP2W18E11_01990	COG0352	thiamine-phosphate diphosphorylase activity
WP2W18E11_01990	COG0351	phosphomethylpyrimidine kinase
WP2W18E11_01990	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WP2W18E11_02010	COG2814	Major facilitator Superfamily
WP2W18E11_02040	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
WP2W18E11_02060	COG1113	amino acid transport
WP2W18E11_02080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
WP2W18E11_02090	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18E11_02110	COG1335	isochorismatase
WP2W18E11_02310	COG1309	transcriptional regulator
WP2W18E11_02340	COG2814	Major facilitator Superfamily
WP2W18E11_02350	COG0583	DNA-binding transcription factor activity
WP2W18E11_02390	COG0667	Aldo Keto reductase
WP2W18E11_02410	COG1309	transcriptional regulator
WP2W18E11_02450	COG1733	regulation of RNA biosynthetic process
WP2W18E11_02460	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP2W18E11_02580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WP2W18E11_02610	COG2329	Antibiotic biosynthesis monooxygenase
WP2W18E11_02640	COG1132	(ABC) transporter
WP2W18E11_02680	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WP2W18E11_02720	COG0427	acetyl-CoA hydrolase
WP2W18E11_02730	COG2205	protein histidine kinase activity
WP2W18E11_02740	COG0745	RESPONSE REGULATOR receiver
WP2W18E11_02760	COG0659	secondary active sulfate transmembrane transporter activity
WP2W18E11_02770	COG4221	oxidoreductase activity
WP2W18E11_02780	COG2873	o-acetylhomoserine
WP2W18E11_02790	COG0488	(ABC) transporter
WP2W18E11_02930	COG0833	amino acid
WP2W18E11_03000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WP2W18E11_03010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WP2W18E11_03040	COG2226	methyltransferase
WP2W18E11_03140	COG0070	glutamate synthase
WP2W18E11_03140	COG0067	glutamate synthase
WP2W18E11_03140	COG0069	glutamate synthase activity
WP2W18E11_03150	COG0493	'glutamate synthase
WP2W18E11_03170	COG1704	LemA family
WP2W18E11_03180	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
WP2W18E11_03220	COG3307	-O-antigen
WP2W18E11_03260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP2W18E11_03280	COG0194	GDP metabolic process
WP2W18E11_03380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WP2W18E11_03400	COG0335	large ribosomal subunit rRNA binding
WP2W18E11_03420	COG5380	lipid catabolic process
WP2W18E11_03430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WP2W18E11_03460	COG5006	permease, DMT superfamily
WP2W18E11_03470	COG5006	permease, DMT superfamily
WP2W18E11_03480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP2W18E11_03490	COG0277	FAD linked oxidase domain protein
WP2W18E11_03510	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
WP2W18E11_03520	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP2W18E11_03550	COG1289	transmembrane transporter activity
WP2W18E11_03570	COG0628	permease
WP2W18E11_03640	COG0833	amino acid
WP2W18E11_03650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WP2W18E11_03660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WP2W18E11_03680	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18E11_03760	COG0583	DNA-binding transcription factor activity
WP2W18E11_03810	COG0752	glycyl-tRNA synthetase alpha subunit
WP2W18E11_03880	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WP2W18E11_03880	COG0617	tRNA 3'-terminal CCA addition
WP2W18E11_03880	COG0517	IMP dehydrogenase activity
WP2W18E11_03890	COG1983	PspC domain protein
WP2W18E11_03910	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_03940	COG0408	coproporphyrinogen oxidase activity
WP2W18E11_03980	COG0513	Belongs to the DEAD box helicase family
WP2W18E11_04000	COG1127	ABC transporter
WP2W18E11_04010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WP2W18E11_04030	COG2854	intermembrane phospholipid transfer
WP2W18E11_04050	COG0598	Magnesium transport protein CorA
WP2W18E11_04070	COG0494	nUDIX hydrolase
WP2W18E11_04080	COG1040	competence protein
WP2W18E11_04090	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WP2W18E11_04130	COG1946	Acyl-CoA thioesterase
WP2W18E11_04140	COG1301	dicarboxylic acid transport
WP2W18E11_04170	COG1959	2 iron, 2 sulfur cluster binding
WP2W18E11_04180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP2W18E11_04180	COG1017	nitric oxide dioxygenase activity
WP2W18E11_04190	COG0433	COG0433 Predicted ATPase
WP2W18E11_04200	COG0626	cystathionine gamma-synthase activity
WP2W18E11_04230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WP2W18E11_04240	COG0088	Forms part of the polypeptide exit tunnel
WP2W18E11_04510	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_04520	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
WP2W18E11_04590	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
WP2W18E11_04600	COG0339	signal peptide processing
WP2W18E11_04610	COG0557	exoribonuclease II activity
WP2W18E11_04700	COG0179	Fumarylacetoacetate (FAA) hydrolase
WP2W18E11_04710	COG1295	ribonuclease BN
WP2W18E11_04780	COG1702	phosphate starvation-inducible protein PhoH
WP2W18E11_04800	COG0741	lytic transglycosylase activity
WP2W18E11_04800	COG1196	nuclear chromosome segregation
WP2W18E11_04800	COG0739	heme binding
WP2W18E11_04860	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
WP2W18E11_04870	COG1183	phosphatidylcholine synthase activity
WP2W18E11_04910	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_04920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP2W18E11_04930	COG1309	transcriptional regulator
WP2W18E11_04960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WP2W18E11_04970	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_05050	COG2969	positive regulation of protein catabolic process
WP2W18E11_05060	COG0625	glutathione transferase activity
WP2W18E11_05070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WP2W18E11_05080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WP2W18E11_05090	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WP2W18E11_05100	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WP2W18E11_05110	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WP2W18E11_05150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WP2W18E11_05170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP2W18E11_05180	COG1408	metallophosphoesterase
WP2W18E11_05190	COG2885	chlorophyll binding
WP2W18E11_05190	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
WP2W18E11_05200	COG2199	diguanylate cyclase activity
WP2W18E11_05280	COG1607	acyl-coa hydrolase
WP2W18E11_05350	COG2350	Protein conserved in bacteria
WP2W18E11_05380	COG3781	membrane
WP2W18E11_05400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WP2W18E11_05410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP2W18E11_05430	COG1862	Preprotein translocase
WP2W18E11_05470	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WP2W18E11_05500	COG0726	polysaccharide deacetylase
WP2W18E11_05530	COG1216	Glycosyl transferase, family 2
WP2W18E11_05630	COG0625	glutathione transferase activity
WP2W18E11_05640	COG0583	DNA-binding transcription factor activity
WP2W18E11_05650	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_05660	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_05680	COG2205	protein histidine kinase activity
WP2W18E11_05690	COG0745	RESPONSE REGULATOR receiver
WP2W18E11_05710	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WP2W18E11_05750	COG2096	Adenosyltransferase
WP2W18E11_05760	COG4206	TonB-dependent receptor
WP2W18E11_05850	COG0285	dihydrofolate synthase activity
WP2W18E11_05890	COG0450	alkyl hydroperoxide reductase
WP2W18E11_05920	COG0477	Major facilitator Superfamily
WP2W18E11_05930	COG1272	protein, Hemolysin III
WP2W18E11_05950	COG2153	protein acetylation
WP2W18E11_05990	COG0183	Belongs to the thiolase family
WP2W18E11_06000	COG2207	Transcriptional regulator
WP2W18E11_06040	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP2W18E11_06080	COG0183	Belongs to the thiolase family
WP2W18E11_06100	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
WP2W18E11_06100	COG2885	chlorophyll binding
WP2W18E11_06120	COG1690	Belongs to the RtcB family
WP2W18E11_06130	COG0833	amino acid
WP2W18E11_06150	COG2233	PERMEase
WP2W18E11_06210	COG2094	Belongs to the DNA glycosylase MPG family
WP2W18E11_06220	COG4772	TonB-dependent receptor
WP2W18E11_06230	COG1902	pentaerythritol trinitrate reductase activity
WP2W18E11_06240	COG0679	Auxin Efflux Carrier
WP2W18E11_06260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP2W18E11_06270	COG0354	folic acid binding
WP2W18E11_06300	COG2233	PERMEase
WP2W18E11_06310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WP2W18E11_06320	COG0251	oxidation-reduction process
WP2W18E11_06330	COG1335	isochorismatase
WP2W18E11_06340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WP2W18E11_06360	COG0596	Alpha beta hydrolase
WP2W18E11_06370	COG3189	MarR family transcriptional regulator
WP2W18E11_06380	COG2824	Alkylphosphonate utilization operon protein PhnA
WP2W18E11_06390	COG3422	double-strand break repair
WP2W18E11_06470	COG0840	transmembrane signaling receptor activity
WP2W18E11_06520	COG5510	response to toxic substance
WP2W18E11_06540	COG2832	Protein of unknown function (DUF454)
WP2W18E11_06550	COG1376	ErfK ybiS ycfS ynhG family protein
WP2W18E11_06570	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WP2W18E11_06590	COG1289	transmembrane transporter activity
WP2W18E11_06600	COG2814	Major facilitator Superfamily
WP2W18E11_06630	COG1115	amino acid carrier protein
WP2W18E11_06640	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP2W18E11_06650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WP2W18E11_06670	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
WP2W18E11_06680	COG3590	peptidase
WP2W18E11_06730	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WP2W18E11_06750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WP2W18E11_06760	COG1077	Cell shape determining protein MreB Mrl
WP2W18E11_06770	COG1792	Involved in formation and maintenance of cell shape
WP2W18E11_06780	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
WP2W18E11_06790	COG0424	maF-like protein
WP2W18E11_06800	COG1530	ribonuclease E activity
WP2W18E11_06820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP2W18E11_06860	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP2W18E11_06910	COG2207	Transcriptional regulator
WP2W18E11_06950	COG0464	growth
WP2W18E11_07050	COG0305	Participates in initiation and elongation during chromosome replication
WP2W18E11_07130	COG0582	viral genome integration into host DNA
WP2W18E11_07150	COG3046	protein related to deoxyribodipyrimidine photolyase
WP2W18E11_07170	COG1113	amino acid transport
WP2W18E11_07180	COG2828	Protein conserved in bacteria
WP2W18E11_07190	COG0142	geranyltranstransferase activity
WP2W18E11_07200	COG2315	Protein conserved in bacteria
WP2W18E11_07230	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP2W18E11_07270	COG2194	sulfuric ester hydrolase activity
WP2W18E11_07280	COG0745	RESPONSE REGULATOR receiver
WP2W18E11_07290	COG0642	Histidine kinase
WP2W18E11_07310	COG0004	ammonium transporteR
WP2W18E11_07320	COG0583	DNA-binding transcription factor activity
WP2W18E11_07370	COG0525	valine-tRNA ligase activity
WP2W18E11_07390	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_07410	COG0393	Putative heavy-metal-binding
WP2W18E11_07420	COG0393	Putative heavy-metal-binding
WP2W18E11_07430	COG1538	Outer membrane efflux protein
WP2W18E11_07450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18E11_07460	COG0671	phosphoesterase, PA-phosphatase related
WP2W18E11_07510	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WP2W18E11_07540	COG1648	precorrin-2 dehydrogenase activity
WP2W18E11_07540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP2W18E11_07550	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WP2W18E11_07620	COG0531	amino acid
WP2W18E11_07650	COG0321	lipoyl(octanoyl) transferase activity
WP2W18E11_07660	COG2921	Belongs to the UPF0250 family
WP2W18E11_07740	COG2009	succinate dehydrogenase
WP2W18E11_07750	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WP2W18E11_07760	COG1053	succinate dehydrogenase
WP2W18E11_07770	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WP2W18E11_07800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP2W18E11_07840	COG2354	Protein conserved in bacteria
WP2W18E11_07850	COG2321	neutral zinc metallopeptidase
WP2W18E11_07910	COG2843	Capsule synthesis protein
WP2W18E11_07950	COG0589	response to stress
WP2W18E11_07970	COG0251	oxidation-reduction process
WP2W18E11_07980	COG1309	transcriptional regulator
WP2W18E11_08010	COG0505	Belongs to the CarA family
WP2W18E11_08060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WP2W18E11_08070	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WP2W18E11_08140	COG0477	Major facilitator Superfamily
WP2W18E11_08150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WP2W18E11_08180	COG1597	lipid kinase activity
WP2W18E11_08190	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
WP2W18E11_08250	COG0584	glycerophosphoryl diester phosphodiesterase
WP2W18E11_08290	COG0741	lytic transglycosylase activity
WP2W18E11_08330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WP2W18E11_08340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP2W18E11_08390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18E11_08400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18E11_08410	COG0778	Nitroreductase
WP2W18E11_08440	COG1929	Belongs to the glycerate kinase type-1 family
WP2W18E11_08450	COG0243	molybdopterin cofactor binding
WP2W18E11_08460	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WP2W18E11_08520	COG1115	amino acid carrier protein
WP2W18E11_08530	COG1113	amino acid transport
WP2W18E11_08550	COG0019	diaminopimelate decarboxylase activity
WP2W18E11_08570	COG2267	carboxylic ester hydrolase activity
WP2W18E11_08580	COG1280	lysine exporter protein (LysE YggA)
WP2W18E11_08590	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
WP2W18E11_08650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18E11_08720	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP2W18E11_08730	COG1136	(ABC) transporter
WP2W18E11_08740	COG2333	competence protein COMEC
WP2W18E11_08740	COG0658	competence protein
WP2W18E11_08760	COG0616	signal peptide processing
WP2W18E11_08760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP2W18E11_08770	COG0596	Alpha beta hydrolase
WP2W18E11_08780	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WP2W18E11_08800	COG0628	permease
WP2W18E11_08870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP2W18E11_08910	COG0823	Involved in the tonB-independent uptake of proteins
WP2W18E11_08950	COG0824	Thioesterase
WP2W18E11_08960	COG1473	amidohydrolase
WP2W18E11_09000	COG0047	phosphoribosylformylglycinamidine synthase activity
WP2W18E11_09000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WP2W18E11_09010	COG2814	Major facilitator Superfamily
WP2W18E11_09040	COG1024	Enoyl-CoA hydratase
WP2W18E11_09050	COG1056	cytidyltransferase-related domain
WP2W18E11_09050	COG1051	belongs to the nudix hydrolase family
WP2W18E11_09080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WP2W18E11_09100	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WP2W18E11_09130	COG4625	pathogenesis
WP2W18E11_09140	COG0583	DNA-binding transcription factor activity
WP2W18E11_09150	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WP2W18E11_09160	COG4208	sulfate ABC transporter
WP2W18E11_09170	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
WP2W18E11_09190	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
WP2W18E11_09200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WP2W18E11_09210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WP2W18E11_09250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP2W18E11_09280	COG0481	GTPase activity
WP2W18E11_09290	COG0681	Belongs to the peptidase S26 family
WP2W18E11_09310	COG0571	ribonuclease III activity
WP2W18E11_09320	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WP2W18E11_09350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WP2W18E11_09370	COG4221	oxidoreductase activity
WP2W18E11_09410	COG0436	Aminotransferase
WP2W18E11_09450	COG0556	nucleotide-excision repair
WP2W18E11_09470	COG2962	Rard protein
WP2W18E11_09560	COG2070	2-Nitropropane dioxygenase
WP2W18E11_09590	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
WP2W18E11_09620	COG1215	transferase activity, transferring glycosyl groups
WP2W18E11_09650	COG0415	Belongs to the DNA photolyase family
WP2W18E11_09670	COG1252	NADH dehydrogenase
WP2W18E11_09680	COG1686	Belongs to the peptidase S11 family
WP2W18E11_09710	COG1187	pseudouridine synthase activity
WP2W18E11_09740	COG0477	Major facilitator Superfamily
WP2W18E11_09750	COG0583	DNA-binding transcription factor activity
WP2W18E11_09780	COG0612	Peptidase, M16
WP2W18E11_09830	COG0352	thiamine-phosphate diphosphorylase activity
WP2W18E11_09900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP2W18E11_09930	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
WP2W18E11_09940	COG0076	glutamate decarboxylase activity
WP2W18E11_09960	COG1522	sequence-specific DNA binding
WP2W18E11_09970	COG3961	Belongs to the TPP enzyme family
WP2W18E11_09980	COG1113	amino acid transport
WP2W18E11_09990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WP2W18E11_10000	COG0573	inorganic phosphate transmembrane transporter activity
WP2W18E11_10020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WP2W18E11_10030	COG0616	signal peptide processing
WP2W18E11_10100	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WP2W18E11_10110	COG1686	Belongs to the peptidase S11 family
WP2W18E11_10160	COG0583	DNA-binding transcription factor activity
WP2W18E11_10170	COG1067	ATP-dependent peptidase activity
WP2W18E11_10180	COG2211	Major facilitator Superfamily
WP2W18E11_10250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WP2W18E11_10260	COG1966	Carbon starvation protein
WP2W18E11_10270	COG2879	small protein
WP2W18E11_10310	COG1301	dicarboxylic acid transport
WP2W18E11_10330	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_10380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
WP2W18E11_10390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WP2W18E11_10400	COG0183	Belongs to the thiolase family
WP2W18E11_10410	COG4829	muconolactone delta-isomerase
WP2W18E11_10460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP2W18E11_10470	COG1741	Belongs to the pirin family
WP2W18E11_10500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP2W18E11_10530	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP2W18E11_10540	COG4605	iron ion homeostasis
WP2W18E11_10550	COG4604	ABC transporter, ATP-binding protein
WP2W18E11_10560	COG4607	ABC-type enterochelin transport system periplasmic component
WP2W18E11_10570	COG4774	siderophore transport
WP2W18E11_10590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP2W18E11_10600	COG1021	2,3-dihydroxybenzoate-AMP ligase
WP2W18E11_10610	COG3433	isochorismatase activity
WP2W18E11_10610	COG1535	isochorismatase
WP2W18E11_10640	COG1132	(ABC) transporter
WP2W18E11_10650	COG5265	(ABC) transporter
WP2W18E11_10660	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
WP2W18E11_10680	COG1169	isochorismate synthase
WP2W18E11_10710	COG3739	integral membrane protein
WP2W18E11_10770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WP2W18E11_10790	COG2840	Smr protein MutS2
WP2W18E11_10840	COG0512	Glutamine amidotransferase of anthranilate synthase
WP2W18E11_10860	COG3104	oligopeptide transport
WP2W18E11_10870	COG0174	glutamine synthetase
WP2W18E11_10890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WP2W18E11_10930	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WP2W18E11_10940	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WP2W18E11_10950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP2W18E11_10990	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WP2W18E11_11000	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
WP2W18E11_11010	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WP2W18E11_11040	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_11050	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WP2W18E11_11060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP2W18E11_11090	COG2223	nitrite transmembrane transporter activity
WP2W18E11_11110	COG0024	Methionine aminopeptidase
WP2W18E11_11120	COG0052	Belongs to the universal ribosomal protein uS2 family
WP2W18E11_11150	COG2207	Transcriptional regulator
WP2W18E11_11200	COG2951	lytic endotransglycosylase activity
WP2W18E11_11210	COG0772	Belongs to the SEDS family
WP2W18E11_11240	COG0842	Transport permease protein
WP2W18E11_11250	COG1131	(ABC) transporter
WP2W18E11_11310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18E11_11330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18E11_11340	COG4215	(ABC) transporter
WP2W18E11_11350	COG4160	amino acid transport
WP2W18E11_11360	COG4598	ABC transporter
WP2W18E11_11380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP2W18E11_11400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP2W18E11_11410	COG0384	phenazine biosynthesis protein PhzF
WP2W18E11_11430	COG1720	tRNA m6t6A37 methyltransferase activity
WP2W18E11_11470	COG0745	RESPONSE REGULATOR receiver
WP2W18E11_11480	COG0642	Histidine kinase
WP2W18E11_11500	COG0494	nUDIX hydrolase
WP2W18E11_11520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP2W18E11_11530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WP2W18E11_11540	COG3139	Protein of unknown function (DUF1315)
WP2W18E11_11560	COG1301	dicarboxylic acid transport
WP2W18E11_11570	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_11610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WP2W18E11_11630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WP2W18E11_11640	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP2W18E11_11680	COG1690	Belongs to the RtcB family
WP2W18E11_11690	COG1234	tRNA 3'-trailer cleavage
WP2W18E11_11700	COG4650	regulator
WP2W18E11_11750	COG2363	Small membrane protein
WP2W18E11_11790	COG0513	Belongs to the DEAD box helicase family
WP2W18E11_11810	COG0778	Nitroreductase
WP2W18E11_11870	COG1286	toxin biosynthetic process
WP2W18E11_11920	COG4783	chaperone-mediated protein folding
WP2W18E11_11930	COG1610	YqeY-like protein
WP2W18E11_11990	COG0515	serine threonine protein kinase
WP2W18E11_11990	COG2815	serine threonine protein kinase
WP2W18E11_12000	COG1278	Cold shock
WP2W18E11_12030	COG3243	poly(R)-hydroxyalkanoic acid synthase
WP2W18E11_12040	COG0786	glutamate:sodium symporter activity
WP2W18E11_12050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WP2W18E11_12050	COG0475	glutathione-regulated potassium exporter activity
WP2W18E11_12060	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_12170	COG1309	transcriptional regulator
WP2W18E11_12190	COG2985	domain, Protein
WP2W18E11_12220	COG2995	paraquat-inducible protein a
WP2W18E11_12230	COG3008	intermembrane lipid transfer
WP2W18E11_12230	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP2W18E11_12250	COG2351	hydroxyisourate hydrolase activity
WP2W18E11_12280	COG5002	protein histidine kinase activity
WP2W18E11_12330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WP2W18E11_12350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WP2W18E11_12360	COG0642	Histidine kinase
WP2W18E11_12370	COG0745	RESPONSE REGULATOR receiver
WP2W18E11_12400	COG1794	racemase activity, acting on amino acids and derivatives
WP2W18E11_12460	COG1301	dicarboxylic acid transport
WP2W18E11_12480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP2W18E11_12490	COG2011	ABC-type metal ion transport system permease component
WP2W18E11_12500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WP2W18E11_12520	COG0151	Belongs to the GarS family
WP2W18E11_12540	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
WP2W18E11_12600	COG2308	Evidence 4 Homologs of previously reported genes of
WP2W18E11_12620	COG1305	Transglutaminase-like
WP2W18E11_12640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP2W18E11_12650	COG0305	Participates in initiation and elongation during chromosome replication
WP2W18E11_12700	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
WP2W18E11_12710	COG1845	cytochrome c oxidase, subunit III
WP2W18E11_12720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WP2W18E11_12780	COG0726	polysaccharide deacetylase
WP2W18E11_12780	COG1649	PFAM Uncharacterised BCR, COG1649
WP2W18E11_12790	COG1215	transferase activity, transferring glycosyl groups
WP2W18E11_12800	COG3658	cytochrome
WP2W18E11_12820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WP2W18E11_12840	COG0583	DNA-binding transcription factor activity
WP2W18E11_12870	COG2890	protein-(glutamine-N5) methyltransferase activity
WP2W18E11_12880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WP2W18E11_12890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WP2W18E11_12920	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_12930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WP2W18E11_12960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WP2W18E11_12990	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
WP2W18E11_13000	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
WP2W18E11_13020	COG2205	protein histidine kinase activity
WP2W18E11_13030	COG0745	RESPONSE REGULATOR receiver
WP2W18E11_13040	COG0174	glutamine synthetase
WP2W18E11_13070	COG0477	Major facilitator Superfamily
WP2W18E11_13080	COG0729	surface antigen
WP2W18E11_13140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP2W18E11_13150	COG2814	Major facilitator Superfamily
WP2W18E11_13180	COG2814	Major facilitator Superfamily
WP2W18E11_13200	COG0583	DNA-binding transcription factor activity
WP2W18E11_13230	COG1187	pseudouridine synthase activity
WP2W18E11_13260	COG0564	pseudouridine synthase activity
WP2W18E11_13270	COG0802	atpase or kinase
WP2W18E11_13280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WP2W18E11_13300	COG1923	regulation of RNA biosynthetic process
WP2W18E11_13310	COG0697	spore germination
WP2W18E11_13330	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP2W18E11_13350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP2W18E11_13360	COG0519	Catalyzes the synthesis of GMP from XMP
WP2W18E11_13360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP2W18E11_13370	COG4302	ethanolamine ammonia-lyase activity
WP2W18E11_13380	COG4303	Ethanolamine ammonia lyase large subunit
WP2W18E11_13390	COG0531	amino acid
WP2W18E11_13430	COG1454	alcohol dehydrogenase
WP2W18E11_13440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP2W18E11_13490	COG0308	aminopeptidase N
WP2W18E11_13570	COG1605	Chorismate mutase
WP2W18E11_13600	COG4772	TonB-dependent receptor
WP2W18E11_13610	COG4774	siderophore transport
WP2W18E11_13740	COG3772	lysozyme
WP2W18E11_13790	COG0583	DNA-binding transcription factor activity
WP2W18E11_13850	COG0488	(ABC) transporter
WP2W18E11_13860	COG0589	response to stress
WP2W18E11_13900	COG3135	benzoate transporter
WP2W18E11_13910	COG1522	sequence-specific DNA binding
WP2W18E11_13930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WP2W18E11_13940	COG0583	DNA-binding transcription factor activity
WP2W18E11_13960	COG0183	Belongs to the thiolase family
WP2W18E11_13980	COG2030	dehydratase
WP2W18E11_14040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WP2W18E11_14060	COG0824	Thioesterase
WP2W18E11_14070	COG1454	alcohol dehydrogenase
WP2W18E11_14120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WP2W18E11_14180	COG0069	glutamate synthase activity
WP2W18E11_14540	COG5410	chromosome segregation
WP2W18E11_14550	COG3567	Phage-associated protein, HI1409 family
WP2W18E11_14590	COG3566	protein conserved in bacteria
WP2W18E11_14810	COG2194	sulfuric ester hydrolase activity
WP2W18E11_14830	COG2814	Major facilitator Superfamily
WP2W18E11_14860	COG0511	ligase activity, forming carbon-carbon bonds
WP2W18E11_14910	COG4264	IucA IucC family
WP2W18E11_14930	COG4264	IucA IucC family
WP2W18E11_14940	COG2423	ornithine cyclodeaminase activity
WP2W18E11_14950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WP2W18E11_14960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WP2W18E11_14960	COG1116	anion transmembrane transporter activity
WP2W18E11_14990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP2W18E11_14990	COG2146	nitrite reductase [NAD(P)H] activity
WP2W18E11_15000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP2W18E11_15010	COG0243	molybdopterin cofactor binding
WP2W18E11_15030	COG0243	molybdopterin cofactor binding
WP2W18E11_15040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WP2W18E11_15070	COG0315	cyclic pyranopterin monophosphate synthase activity
WP2W18E11_15070	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP2W18E11_15080	COG0303	'Molybdopterin
WP2W18E11_15100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP2W18E11_15110	COG0697	spore germination
WP2W18E11_15160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP2W18E11_15300	COG2204	response regulator
WP2W18E11_15310	COG3852	Histidine kinase
WP2W18E11_15350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WP2W18E11_15360	COG0575	Belongs to the CDS family
WP2W18E11_15430	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP2W18E11_15450	COG2137	regulation of response to DNA damage stimulus
WP2W18E11_15470	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
WP2W18E11_15480	COG1011	Hydrolase
WP2W18E11_15510	COG1522	sequence-specific DNA binding
WP2W18E11_15530	COG1113	amino acid transport
WP2W18E11_15590	COG0659	secondary active sulfate transmembrane transporter activity
WP2W18E11_15660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP2W18E11_15660	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
WP2W18E11_15660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP2W18E11_15670	COG1105	Belongs to the carbohydrate kinase PfkB family
WP2W18E11_15680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2W18E11_15680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WP2W18E11_15720	COG3193	protein, possibly involved in utilization of glycolate and propanediol
WP2W18E11_15740	COG0024	Methionine aminopeptidase
WP2W18E11_15750	COG0583	DNA-binding transcription factor activity
WP2W18E11_15770	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WP2W18E11_15780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WP2W18E11_15790	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
WP2W18E11_15790	COG0517	IMP dehydrogenase activity
WP2W18E11_15840	COG0552	protein localization to endoplasmic reticulum
WP2W18E11_15880	COG4890	Cyd operon protein YbgT
WP2W18E11_15890	COG1294	oxidase, subunit
WP2W18E11_15920	COG1585	Membrane protein implicated in regulation of membrane protease activity
WP2W18E11_15940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP2W18E11_15970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP2W18E11_15980	COG0569	domain protein
WP2W18E11_15990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WP2W18E11_16050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WP2W18E11_16060	COG0542	response to heat
WP2W18E11_16110	COG1902	pentaerythritol trinitrate reductase activity
WP2W18E11_16110	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP2W18E11_16190	COG0148	phosphopyruvate hydratase activity
WP2W18E11_16200	COG2323	membrane
WP2W18E11_16250	COG4773	Receptor
WP2W18E11_16290	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
WP2W18E11_16310	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
WP2W18E11_16320	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WP2W18E11_16330	COG0183	Belongs to the thiolase family
WP2W18E11_16340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WP2W18E11_16350	COG0596	Alpha beta hydrolase
WP2W18E11_16360	COG2271	Major facilitator Superfamily
WP2W18E11_16370	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WP2W18E11_16380	COG3485	protocatechuate 3,4-dioxygenase
WP2W18E11_16390	COG3485	protocatechuate 3,4-dioxygenase
WP2W18E11_16400	COG0710	3-dehydroquinate dehydratase activity
WP2W18E11_16410	COG3420	alginic acid biosynthetic process
WP2W18E11_16420	COG3659	wide pore channel activity
WP2W18E11_16430	COG4993	Dehydrogenase
WP2W18E11_16450	COG2391	methyltransferase activity
WP2W18E11_16480	COG1414	Transcriptional regulator
WP2W18E11_16490	COG0583	DNA-binding transcription factor activity
WP2W18E11_16500	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_16550	COG2814	Major facilitator Superfamily
WP2W18E11_16570	COG0154	amidase activity
WP2W18E11_16610	COG4638	Rieske (2fe-2S)
WP2W18E11_16630	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_16650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WP2W18E11_16670	COG3733	amine oxidase
WP2W18E11_16690	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18E11_16700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WP2W18E11_16710	COG0183	Belongs to the thiolase family
WP2W18E11_16720	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WP2W18E11_16730	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
WP2W18E11_16750	COG4829	muconolactone delta-isomerase
WP2W18E11_16760	COG4948	Mandelate Racemase Muconate Lactonizing
WP2W18E11_16770	COG0583	DNA-binding transcription factor activity
WP2W18E11_16790	COG2186	Transcriptional regulator
WP2W18E11_16830	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18E11_16840	COG2351	hydroxyisourate hydrolase activity
WP2W18E11_16850	COG2233	PERMEase
WP2W18E11_16870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP2W18E11_16880	COG2186	Transcriptional regulator
WP2W18E11_16900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WP2W18E11_16920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WP2W18E11_16960	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP2W18E11_16960	COG1902	pentaerythritol trinitrate reductase activity
WP2W18E11_17030	COG1309	transcriptional regulator
WP2W18E11_17040	COG0583	DNA-binding transcription factor activity
WP2W18E11_17050	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_17060	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_17070	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_17090	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_17110	COG0318	PFAM AMP-dependent synthetase and ligase
WP2W18E11_17130	COG1309	transcriptional regulator
WP2W18E11_17190	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WP2W18E11_17200	COG2259	Doxx family
WP2W18E11_17220	COG4993	Dehydrogenase
WP2W18E11_17330	COG0583	DNA-binding transcription factor activity
WP2W18E11_17380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP2W18E11_17390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP2W18E11_17480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP2W18E11_17510	COG2271	Major facilitator Superfamily
WP2W18E11_17560	COG2207	Transcriptional regulator
WP2W18E11_17570	COG1064	alcohol dehydrogenase
WP2W18E11_17610	COG1120	ATPase activity
WP2W18E11_17650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WP2W18E11_17820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WP2W18E11_17900	COG1073	alpha beta
WP2W18E11_17920	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_17950	COG2207	Transcriptional regulator
WP2W18E11_17970	COG0556	nucleotide-excision repair
WP2W18E11_18010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WP2W18E11_18020	COG1074	ATP-dependent DNA helicase activity
WP2W18E11_18160	COG3539	Fimbrial protein
WP2W18E11_18210	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
WP2W18E11_18230	COG0753	catalase activity
WP2W18E11_18280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP2W18E11_18300	COG2205	protein histidine kinase activity
WP2W18E11_18310	COG0745	RESPONSE REGULATOR receiver
WP2W18E11_18320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18E11_18330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18E11_18430	COG1535	isochorismatase
WP2W18E11_18430	COG3433	isochorismatase activity
WP2W18E11_18440	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_18450	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
WP2W18E11_18460	COG4149	molybdate abc transporter
WP2W18E11_18470	COG0725	ABC transporter, periplasmic molybdate-binding protein
WP2W18E11_18490	COG4638	Rieske (2fe-2S)
WP2W18E11_18500	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
WP2W18E11_18510	COG0543	2 iron, 2 sulfur cluster binding
WP2W18E11_18510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP2W18E11_18540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WP2W18E11_18560	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_18600	COG2207	Transcriptional regulator
WP2W18E11_18610	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_18620	COG2610	gluconate transmembrane transporter activity
WP2W18E11_18680	COG0583	DNA-binding transcription factor activity
WP2W18E11_18710	COG2031	fatty acid transporter
WP2W18E11_18720	COG0183	Belongs to the thiolase family
WP2W18E11_18730	COG0583	DNA-binding transcription factor activity
WP2W18E11_18740	COG0583	DNA-binding transcription factor activity
WP2W18E11_18770	COG1027	Aspartate ammonia-lyase
WP2W18E11_18790	COG0477	Major facilitator Superfamily
WP2W18E11_18810	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WP2W18E11_18820	COG1733	regulation of RNA biosynthetic process
WP2W18E11_18830	COG3708	Transcriptional regulator
WP2W18E11_18830	COG2207	Transcriptional regulator
WP2W18E11_18860	COG0730	response to heat
WP2W18E11_18900	COG3781	membrane
WP2W18E11_18910	COG1063	alcohol dehydrogenase
WP2W18E11_18930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP2W18E11_18940	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP2W18E11_18950	COG0022	dehydrogenase e1 component
WP2W18E11_18960	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WP2W18E11_18970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WP2W18E11_19000	COG3706	GGDEF domain
WP2W18E11_19040	COG0133	tryptophan synthase activity
WP2W18E11_19060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WP2W18E11_19120	COG0583	DNA-binding transcription factor activity
WP2W18E11_19130	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WP2W18E11_19150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WP2W18E11_19270	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP2W18E11_19280	COG4773	Receptor
WP2W18E11_19320	COG0730	response to heat
WP2W18E11_19330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP2W18E11_19370	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
WP2W18E11_19400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP2W18E11_19420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WP2W18E11_19450	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_19460	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_19470	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18E11_19480	COG2207	Transcriptional regulator
WP2W18E11_19490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP2W18E11_19500	COG0776	regulation of translation
WP2W18E11_19550	COG0822	iron-sulfur transferase activity
WP2W18E11_19560	COG0316	Belongs to the HesB IscA family
WP2W18E11_19620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WP2W18E11_19660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP2W18E11_19670	COG0702	epimerase
WP2W18E11_19750	COG0601	transmembrane transport
WP2W18E11_19760	COG0339	signal peptide processing
WP2W18E11_19770	COG4166	transmembrane transport
WP2W18E11_19850	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WP2W18E11_19860	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WP2W18E11_19890	COG2431	L-lysine efflux transmembrane transporter activity
WP2W18E11_19920	COG0776	regulation of translation
WP2W18E11_20050	COG0084	hydrolase, TatD family'
WP2W18E11_20090	COG1663	tetraacyldisaccharide 4'-kinase activity
WP2W18E11_20100	COG1132	(ABC) transporter
WP2W18E11_20120	COG0811	peptide transport
WP2W18E11_20130	COG1475	DNA binding
WP2W18E11_20140	COG1192	Involved in chromosome partitioning
WP2W18E11_20160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WP2W18E11_20170	COG3178	'Phosphotransferase
WP2W18E11_20190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP2W18E11_20240	COG0424	maF-like protein
WP2W18E11_20250	COG2850	peptidyl-arginine hydroxylation
WP2W18E11_20270	COG0640	Transcriptional regulator
WP2W18E11_20290	COG3619	membrane
WP2W18E11_20300	COG3122	Protein conserved in bacteria
WP2W18E11_20320	COG1132	(ABC) transporter
WP2W18E11_20360	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
WP2W18E11_20370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP2W18E11_20390	COG0506	proline dehydrogenase activity
WP2W18E11_20390	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WP2W18E11_20390	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WP2W18E11_20430	COG3698	Phosphodiester glycosidase
WP2W18E11_20450	COG2353	YceI-like domain
WP2W18E11_20470	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WP2W18E11_20560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WP2W18E11_20560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WP2W18E11_20610	COG3539	Fimbrial protein
WP2W18E11_20670	COG0697	spore germination
WP2W18E11_20690	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
WP2W18E11_20710	COG0583	DNA-binding transcription factor activity
WP2W18E11_20730	COG1309	transcriptional regulator
WP2W18E11_20760	COG1522	sequence-specific DNA binding
WP2W18E11_20780	COG1126	abc transporter atp-binding protein
WP2W18E11_20790	COG0765	amino acid transport
WP2W18E11_20800	COG0765	amino acid transport
WP2W18E11_20860	COG1464	Belongs to the NlpA lipoprotein family
WP2W18E11_20880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WP2W18E11_20890	COG2011	ABC-type metal ion transport system permease component
WP2W18E11_20900	COG0012	GTP binding
WP2W18E11_20950	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
WP2W18E11_21030	COG0386	Belongs to the glutathione peroxidase family
WP2W18E11_21050	COG0436	Aminotransferase
WP2W18E11_21060	COG1301	dicarboxylic acid transport
WP2W18E11_21130	COG3634	alkyl hydroperoxide reductase activity
WP2W18E11_21160	COG0583	DNA-binding transcription factor activity
WP2W18E11_21170	COG0431	NADPH-dependent FMN reductase
WP2W18E11_21180	COG0798	PFAM Bile acid sodium symporter
WP2W18E11_21200	COG0640	Transcriptional regulator
WP2W18E11_21230	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
WP2W18E11_21250	COG0583	DNA-binding transcription factor activity
WP2W18E11_21270	COG1953	Uracil, thiamine, allantoin
WP2W18E11_21290	COG2175	clavaminate synthase activity
WP2W18E11_21300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WP2W18E11_21310	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
WP2W18E11_21320	COG4521	taurine ABC transporter
WP2W18E11_21340	COG0477	Major facilitator Superfamily
WP2W18E11_21380	COG1271	oxidase subunit
WP2W18E11_21390	COG1294	oxidase, subunit
WP2W18E11_21410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP2W18E11_21450	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WP2W18E11_21490	COG3052	prosthetic group binding
WP2W18E11_21500	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
WP2W18E11_21550	COG1346	cytolysis
WP2W18E11_21570	COG0583	DNA-binding transcription factor activity
WP2W18E11_21580	COG0625	glutathione transferase activity
WP2W18E11_21590	COG0625	glutathione transferase activity
WP2W18E11_21630	COG0583	DNA-binding transcription factor activity
WP2W18E11_21640	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_21660	COG1045	serine acetyltransferase
WP2W18E11_21670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP2W18E11_21680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WP2W18E11_21690	COG1280	lysine exporter protein (LysE YggA)
WP2W18E11_21720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18E11_21730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18E11_21750	COG0765	amino acid transport
WP2W18E11_21760	COG0765	amino acid transport
WP2W18E11_21830	COG0784	Response regulator, receiver
WP2W18E11_21830	COG2205	protein histidine kinase activity
WP2W18E11_21870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP2W18E11_21910	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_22010	COG0583	DNA-binding transcription factor activity
WP2W18E11_22030	COG2814	Major facilitator Superfamily
WP2W18E11_22060	COG0318	PFAM AMP-dependent synthetase and ligase
WP2W18E11_22070	COG1309	transcriptional regulator
WP2W18E11_22080	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_22090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WP2W18E11_22100	COG1024	Enoyl-CoA hydratase
WP2W18E11_22110	COG4770	biotin carboxylase activity
WP2W18E11_22130	COG0583	DNA-binding transcription factor activity
WP2W18E11_22160	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_22180	COG2814	Major facilitator Superfamily
WP2W18E11_22200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WP2W18E11_22210	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
WP2W18E11_22220	COG2814	Major facilitator Superfamily
WP2W18E11_22230	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_22240	COG1024	Enoyl-CoA hydratase
WP2W18E11_22250	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_22260	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP2W18E11_22270	COG0183	Belongs to the thiolase family
WP2W18E11_22290	COG2814	Major facilitator Superfamily
WP2W18E11_22310	COG1024	Enoyl-CoA hydratase
WP2W18E11_22330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WP2W18E11_22340	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_22350	COG2814	Major facilitator Superfamily
WP2W18E11_22360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP2W18E11_22370	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
WP2W18E11_22400	COG3842	ATPase activity
WP2W18E11_22410	COG1840	ABC-type Fe3 transport system, periplasmic component
WP2W18E11_22440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP2W18E11_22450	COG1414	Transcriptional regulator
WP2W18E11_22560	COG2050	protein possibly involved in aromatic compounds catabolism
WP2W18E11_22580	COG3327	negative regulation of DNA-templated transcription, initiation
WP2W18E11_22590	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
WP2W18E11_22600	COG0183	Belongs to the thiolase family
WP2W18E11_22610	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP2W18E11_22620	COG1024	Enoyl-CoA hydratase
WP2W18E11_22630	COG1024	Enoyl-CoA hydratase
WP2W18E11_22640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP2W18E11_22650	COG2151	metal-sulfur cluster biosynthetic enzyme
WP2W18E11_22660	COG3396	Phenylacetate-CoA oxygenase
WP2W18E11_22670	COG3460	Phenylacetate-CoA oxygenase
WP2W18E11_22680	COG3396	Phenylacetate-CoA oxygenase
WP2W18E11_22690	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18E11_22690	COG2030	dehydratase
WP2W18E11_22700	COG1760	l-serine dehydratase
WP2W18E11_22740	COG0789	Transcriptional regulator
WP2W18E11_22760	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
WP2W18E11_22770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP2W18E11_22800	COG2807	transmembrane transport
WP2W18E11_22810	COG0590	tRNA wobble adenosine to inosine editing
WP2W18E11_22910	COG2885	chlorophyll binding
WP2W18E11_23220	COG1116	anion transmembrane transporter activity
WP2W18E11_23230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18E11_23250	COG0864	Transcriptional regulator
WP2W18E11_23280	COG1733	regulation of RNA biosynthetic process
WP2W18E11_23290	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP2W18E11_23300	COG0439	Biotin carboxylase
WP2W18E11_23330	COG1063	alcohol dehydrogenase
WP2W18E11_23340	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP2W18E11_23410	COG3210	domain, Protein
WP2W18E11_23420	COG2831	hemolysin activation secretion protein
WP2W18E11_23430	COG0038	chloride channel
WP2W18E11_23440	COG4770	biotin carboxylase activity
WP2W18E11_23480	COG1914	H( )-stimulated, divalent metal cation uptake system
WP2W18E11_23490	COG0583	DNA-binding transcription factor activity
WP2W18E11_23510	COG1595	DNA-templated transcription, initiation
WP2W18E11_23530	COG3220	belongs to the UPF0276 family
WP2W18E11_23650	COG1309	transcriptional regulator
WP2W18E11_23760	COG3038	cytochrome b561
WP2W18E11_23770	COG0753	catalase activity
WP2W18E11_23800	COG2207	Transcriptional regulator
WP2W18E11_23840	COG1278	Cold shock
WP2W18E11_23900	COG0531	amino acid
WP2W18E11_23910	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WP2W18E11_23940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
WP2W18E11_23970	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WP2W18E11_23990	COG4122	O-methyltransferase activity
WP2W18E11_24050	COG1538	Outer membrane efflux protein
WP2W18E11_24060	COG1137	ATPase activity
WP2W18E11_24070	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
WP2W18E11_24090	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WP2W18E11_24200	COG2814	Major facilitator Superfamily
WP2W18E11_24220	COG0668	transmembrane transport
WP2W18E11_24300	COG1309	transcriptional regulator
WP2W18E11_24320	COG2226	methyltransferase
WP2W18E11_24370	COG1278	Cold shock
WP2W18E11_24380	COG1560	Kdo2-lipid A biosynthetic process
WP2W18E11_24390	COG1280	lysine exporter protein (LysE YggA)
WP2W18E11_24450	COG1570	exodeoxyribonuclease VII activity
WP2W18E11_24610	COG2871	sodium ion transport
WP2W18E11_24630	COG0583	DNA-binding transcription factor activity
WP2W18E11_24640	COG4638	Rieske (2fe-2S)
WP2W18E11_24650	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
WP2W18E11_24660	COG0633	Ferredoxin
WP2W18E11_24660	COG0543	2 iron, 2 sulfur cluster binding
WP2W18E11_24670	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_24680	COG3135	benzoate transporter
WP2W18E11_24690	COG2814	Major facilitator Superfamily
WP2W18E11_24720	COG1643	Atp-dependent helicase
WP2W18E11_24770	COG3634	alkyl hydroperoxide reductase activity
WP2W18E11_24810	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WP2W18E11_24820	COG0625	glutathione transferase activity
WP2W18E11_24840	COG2885	chlorophyll binding
WP2W18E11_24910	COG0542	response to heat
WP2W18E11_24940	COG1765	OsmC-like protein
WP2W18E11_24960	COG0667	Aldo Keto reductase
WP2W18E11_24990	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WP2W18E11_25010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP2W18E11_25030	COG0527	aspartate kinase activity
WP2W18E11_25050	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WP2W18E11_25070	COG3038	cytochrome b561
WP2W18E11_25080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WP2W18E11_25090	COG2252	PERMEase
WP2W18E11_25110	COG1741	Belongs to the pirin family
WP2W18E11_25120	COG1309	transcriptional regulator
WP2W18E11_25150	COG2072	flavoprotein involved in K transport
WP2W18E11_25160	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
WP2W18E11_25170	COG0583	DNA-binding transcription factor activity
WP2W18E11_25200	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
WP2W18E11_25260	COG1944	ATP diphosphatase activity
WP2W18E11_25300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WP2W18E11_25330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP2W18E11_25360	COG2814	Major facilitator Superfamily
WP2W18E11_25370	COG1024	Enoyl-CoA hydratase
WP2W18E11_25380	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18E11_25400	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_25450	COG2186	Transcriptional regulator
WP2W18E11_25460	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18E11_25480	COG4948	Mandelate Racemase Muconate Lactonizing
WP2W18E11_25490	COG2271	Major facilitator Superfamily
WP2W18E11_25500	COG2721	sulfolactate sulfo-lyase activity
WP2W18E11_25510	COG0697	spore germination
WP2W18E11_25550	COG1113	amino acid transport
WP2W18E11_25590	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18E11_25630	COG0531	amino acid
WP2W18E11_25650	COG1113	amino acid transport
WP2W18E11_25720	COG4269	membrane
WP2W18E11_25800	COG2059	Chromate
WP2W18E11_25830	COG2015	COG2015, Alkyl sulfatase and related hydrolases
WP2W18E11_25860	COG1230	cation diffusion facilitator family transporter
WP2W18E11_25900	COG2814	Major facilitator Superfamily
WP2W18E11_26110	COG0582	viral genome integration into host DNA
WP2W18E11_26130	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP2W18E11_26130	COG1902	pentaerythritol trinitrate reductase activity
WP2W18E11_26150	COG5001	Diguanylate cyclase
WP2W18E11_26150	COG4251	negative regulation of phosphorylation
WP2W18E11_26150	COG3706	GGDEF domain
WP2W18E11_26150	COG2203	Gaf domain
WP2W18E11_26170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP2W18E11_26200	COG4172	Belongs to the ABC transporter superfamily
WP2W18E11_26210	COG4239	(ABC) transporter, permease
WP2W18E11_26220	COG4174	ABC transporter (Permease)
WP2W18E11_26230	COG4166	transmembrane transport
WP2W18E11_26240	COG1388	LysM domain
WP2W18E11_26240	COG0741	lytic transglycosylase activity
WP2W18E11_26330	COG0583	DNA-binding transcription factor activity
WP2W18E11_26340	COG1279	arginine transmembrane transporter activity
WP2W18E11_26360	COG0789	Transcriptional regulator
WP2W18E11_26380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP2W18E11_26390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP2W18E11_26400	COG0006	proline dipeptidase activity
WP2W18E11_26470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WP2W18E11_26500	COG3384	dioxygenase
WP2W18E11_26520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WP2W18E11_26530	COG2878	Part of a membrane complex involved in electron transport
WP2W18E11_26540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WP2W18E11_26590	COG0768	penicillin binding
WP2W18E11_26600	COG0742	ribosomal rna small subunit methyltransferase
WP2W18E11_26630	COG0830	nickel cation binding
WP2W18E11_26650	COG0804	urea catabolic process
WP2W18E11_26700	COG3015	lipoprotein NlpE involved in copper resistance
WP2W18E11_26730	COG1253	flavin adenine dinucleotide binding
WP2W18E11_26740	COG2851	Citrate transporter
WP2W18E11_26840	COG1773	rubredoxin
WP2W18E11_26850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP2W18E11_26860	COG2267	carboxylic ester hydrolase activity
WP2W18E11_26870	COG0583	DNA-binding transcription factor activity
WP2W18E11_26920	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
WP2W18E11_26930	COG4181	ATPase activity
WP2W18E11_27020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WP2W18E11_27060	COG0306	phosphate transporter
WP2W18E11_27120	COG3958	Transketolase
WP2W18E11_27130	COG3959	Transketolase, thiamine diphosphate binding domain
WP2W18E11_27140	COG2271	Major facilitator Superfamily
WP2W18E11_27150	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_27160	COG0583	DNA-binding transcription factor activity
WP2W18E11_27210	COG2223	nitrite transmembrane transporter activity
WP2W18E11_27220	COG2207	Transcriptional regulator
WP2W18E11_27230	COG2066	Belongs to the glutaminase family
WP2W18E11_27240	COG0242	peptide deformylase activity
WP2W18E11_27250	COG0477	Major facilitator Superfamily
WP2W18E11_27270	COG0028	Belongs to the TPP enzyme family
WP2W18E11_27300	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_27310	COG2267	carboxylic ester hydrolase activity
WP2W18E11_27330	COG2271	Major facilitator Superfamily
WP2W18E11_27360	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_27400	COG1414	Transcriptional regulator
WP2W18E11_27430	COG1024	Enoyl-CoA hydratase
WP2W18E11_27450	COG1215	transferase activity, transferring glycosyl groups
WP2W18E11_27460	COG1649	PFAM Uncharacterised BCR, COG1649
WP2W18E11_27460	COG0726	polysaccharide deacetylase
WP2W18E11_27480	COG4681	YaeQ
WP2W18E11_27500	COG0523	cobalamin synthesis protein
WP2W18E11_27520	COG1607	acyl-coa hydrolase
WP2W18E11_27540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WP2W18E11_27550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WP2W18E11_27560	COG1309	transcriptional regulator
WP2W18E11_27610	COG2040	homocysteine
WP2W18E11_27620	COG0531	amino acid
WP2W18E11_27730	COG1595	DNA-templated transcription, initiation
WP2W18E11_27750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP2W18E11_27760	COG0477	Major facilitator Superfamily
WP2W18E11_27980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP2W18E11_28150	COG0592	DNA-directed DNA polymerase activity
WP2W18E11_28480	COG3755	Protein conserved in bacteria
WP2W18E11_28570	COG1484	DNA-dependent DNA replication
WP2W18E11_28810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP2W18E11_28940	COG0405	Gamma-glutamyltransferase
WP2W18E11_28950	COG2814	Major facilitator Superfamily
WP2W18E11_28970	COG2050	protein possibly involved in aromatic compounds catabolism
WP2W18E11_29000	COG1090	epimerase
WP2W18E11_29040	COG0420	3'-5' exonuclease activity
WP2W18E11_29090	COG0735	belongs to the Fur family
WP2W18E11_29100	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP2W18E11_29110	COG2914	Belongs to the UPF0125 (RnfH) family
WP2W18E11_29140	COG0121	glutamine amidotransferase
WP2W18E11_29170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WP2W18E11_29190	COG0210	DNA helicase
WP2W18E11_29210	COG2885	chlorophyll binding
WP2W18E11_29220	COG0204	Acyl-transferase
WP2W18E11_29250	COG2894	cell division
WP2W18E11_29290	COG1280	lysine exporter protein (LysE YggA)
WP2W18E11_29300	COG1674	ftsk spoiiie
WP2W18E11_29310	COG0492	ferredoxin-NADP+ reductase activity
WP2W18E11_29320	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WP2W18E11_29340	COG0456	acetyltransferase
WP2W18E11_29370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP2W18E11_29380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WP2W18E11_29400	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WP2W18E11_29450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP2W18E11_29450	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WP2W18E11_29480	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18E11_29490	COG4638	Rieske (2fe-2S)
WP2W18E11_29520	COG0473	3-isopropylmalate dehydrogenase activity
WP2W18E11_29530	COG0583	DNA-binding transcription factor activity
WP2W18E11_29550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP2W18E11_29620	COG0358	DNA primase activity
WP2W18E11_29650	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WP2W18E11_29670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WP2W18E11_29730	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP2W18E11_29750	COG0351	phosphomethylpyrimidine kinase
WP2W18E11_29750	COG0352	thiamine-phosphate diphosphorylase activity
WP2W18E11_29750	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WP2W18E11_29760	COG1652	LysM domain
WP2W18E11_29810	COG1399	metal-binding, possibly nucleic acid-binding protein
WP2W18E11_29820	COG3101	peptidyl-lysine hydroxylation
WP2W18E11_29830	COG0009	L-threonylcarbamoyladenylate synthase
WP2W18E11_29840	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
WP2W18E11_29850	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WP2W18E11_29880	COG4106	trans-aconitate 2-methyltransferase activity
WP2W18E11_29910	COG0596	Alpha beta hydrolase
WP2W18E11_29910	COG2226	methyltransferase
WP2W18E11_29910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WP2W18E11_29930	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
WP2W18E11_29940	COG2223	nitrite transmembrane transporter activity
WP2W18E11_29980	COG1196	nuclear chromosome segregation
WP2W18E11_30000	COG0730	response to heat
WP2W18E11_30030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WP2W18E11_30050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP2W18E11_30150	COG0489	protein tyrosine kinase activity
WP2W18E11_30170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2W18E11_30170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2W18E11_30240	COG2515	1-aminocyclopropane-1-carboxylate deaminase
WP2W18E11_30250	COG2081	HI0933 family
WP2W18E11_30270	COG0668	transmembrane transport
WP2W18E11_30310	COG0583	DNA-binding transcription factor activity
WP2W18E11_30320	COG1278	Cold shock
WP2W18E11_30350	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2W18E11_30360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WP2W18E11_30420	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WP2W18E11_30470	COG2199	diguanylate cyclase activity
WP2W18E11_30490	COG2205	protein histidine kinase activity
WP2W18E11_30500	COG0745	RESPONSE REGULATOR receiver
WP2W18E11_30530	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP2W18E11_30620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WP2W18E11_30650	COG0583	DNA-binding transcription factor activity
WP2W18E11_30690	COG1473	amidohydrolase
WP2W18E11_30750	COG0583	DNA-binding transcription factor activity
WP2W18E11_30780	COG0583	DNA-binding transcription factor activity
WP2W18E11_30790	COG1053	succinate dehydrogenase
WP2W18E11_30820	COG1309	transcriptional regulator
WP2W18E11_30850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WP2W18E11_30860	COG2814	Major facilitator Superfamily
WP2W18E11_30870	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_30880	COG0583	DNA-binding transcription factor activity
WP2W18E11_30890	COG1063	alcohol dehydrogenase
WP2W18E11_30910	COG0582	viral genome integration into host DNA
WP2W18E11_30920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP2W18E11_31290	COG3409	Peptidoglycan-binding domain 1 protein
WP2W18E11_31290	COG0860	N-Acetylmuramoyl-L-alanine amidase
WP2W18E11_31380	COG4695	Portal protein
WP2W18E11_31400	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WP2W18E11_31410	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
WP2W18E11_31420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WP2W18E11_31460	COG2132	Multicopper oxidase
WP2W18E11_31480	COG0561	phosphatase activity
WP2W18E11_31490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WP2W18E11_31540	COG1214	PFAM Peptidase M22, glycoprotease
WP2W18E11_31660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WP2W18E11_31670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WP2W18E11_31680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WP2W18E11_31750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP2W18E11_31770	COG1846	Transcriptional regulator
WP2W18E11_31780	COG1764	response to oxidative stress
WP2W18E11_31860	COG0037	tRNA processing
WP2W18E11_31930	COG0072	phenylalanine-tRNA ligase activity
WP2W18E11_31990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WP2W18E11_32010	COG1238	metal cluster binding
WP2W18E11_32020	COG0625	glutathione transferase activity
WP2W18E11_32050	COG0318	PFAM AMP-dependent synthetase and ligase
WP2W18E11_32060	COG3028	Belongs to the UPF0307 family
WP2W18E11_32070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2W18E11_32110	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WP2W18E11_32120	COG0617	tRNA 3'-terminal CCA addition
WP2W18E11_32130	COG1555	photosystem II stabilization
WP2W18E11_32140	COG3956	TIGRFAM MazG family protein
WP2W18E11_32150	COG4221	oxidoreductase activity
WP2W18E11_32160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP2W18E11_32200	COG2205	protein histidine kinase activity
WP2W18E11_32200	COG5002	protein histidine kinase activity
WP2W18E11_32200	COG0784	Response regulator, receiver
WP2W18E11_32210	COG1024	Enoyl-CoA hydratase
WP2W18E11_32220	COG2084	Dehydrogenase
WP2W18E11_32230	COG3622	Belongs to the hyi family
WP2W18E11_32290	COG0697	spore germination
WP2W18E11_32310	COG2814	Major facilitator Superfamily
WP2W18E11_32390	COG2072	flavoprotein involved in K transport
WP2W18E11_32400	COG0492	ferredoxin-NADP+ reductase activity
WP2W18E11_32410	COG0431	NADPH-dependent FMN reductase
WP2W18E11_32420	COG0798	PFAM Bile acid sodium symporter
WP2W18E11_32440	COG0640	Transcriptional regulator
WP2W18E11_32510	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18E11_32520	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18E11_32570	COG2132	Multicopper oxidase
WP2W18E11_32600	COG2205	protein histidine kinase activity
WP2W18E11_32790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP2W18E11_32820	COG0583	DNA-binding transcription factor activity
WP2W18E11_32830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WP2W18E11_32860	COG0084	hydrolase, TatD family'
WP2W18E11_32890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
WP2W18E11_32930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WP2W18E11_32940	COG0440	acetolactate synthase activity
WP2W18E11_32950	COG0028	Belongs to the TPP enzyme family
WP2W18E11_32990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18E11_33000	COG0577	efflux transmembrane transporter activity
WP2W18E11_33000	COG1136	(ABC) transporter
WP2W18E11_33040	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WP2W18E11_33050	COG1162	GTPase activity
WP2W18E11_33070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WP2W18E11_33110	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP2W18E11_33150	COG1426	Protein conserved in bacteria
WP2W18E11_33220	COG0793	Belongs to the peptidase S41A family
WP2W18E11_33250	COG2267	carboxylic ester hydrolase activity
WP2W18E11_33270	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18E11_33280	COG3265	gluconokinase activity
WP2W18E11_33300	COG0800	Aldolase
WP2W18E11_33320	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WP2W18E11_33330	COG0280	phosphate acetyltransferase
WP2W18E11_33330	COG0857	belongs to the CobB CobQ family
WP2W18E11_33340	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
WP2W18E11_33340	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
WP2W18E11_33380	COG0740	serine-type endopeptidase activity
WP2W18E11_33400	COG4774	siderophore transport
WP2W18E11_33420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP2W18E11_33440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WP2W18E11_33440	COG2813	Specifically methylates the guanine in position
WP2W18E11_33640	COG0788	formyltetrahydrofolate deformylase activity
WP2W18E11_33690	COG4651	solute:proton antiporter activity
WP2W18E11_33690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WP2W18E11_33730	COG0724	RNA recognition motif
WP2W18E11_33740	COG0210	DNA helicase
WP2W18E11_33790	COG1733	regulation of RNA biosynthetic process
WP2W18E11_33810	COG2900	Belongs to the SlyX family
WP2W18E11_33840	COG1560	Kdo2-lipid A biosynthetic process
WP2W18E11_33860	COG1301	dicarboxylic acid transport
WP2W18E11_33970	COG0473	3-isopropylmalate dehydrogenase activity
WP2W18E11_34020	COG0583	DNA-binding transcription factor activity
WP2W18E11_34100	COG0583	DNA-binding transcription factor activity
WP2W18E11_34120	COG0625	glutathione transferase activity
WP2W18E11_34130	COG2378	regulation of single-species biofilm formation
WP2W18E11_34140	COG0546	phosphoglycolate phosphatase activity
WP2W18E11_34160	COG1530	ribonuclease E activity
WP2W18E11_34170	COG0318	PFAM AMP-dependent synthetase and ligase
WP2W18E11_34180	COG0583	DNA-binding transcription factor activity
WP2W18E11_34190	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_34200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WP2W18E11_34220	COG0534	Mate efflux family protein
WP2W18E11_34250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WP2W18E11_34300	COG0493	'glutamate synthase
WP2W18E11_34320	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
WP2W18E11_34330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP2W18E11_34360	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WP2W18E11_34380	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
WP2W18E11_34380	COG0644	oxidoreductase
WP2W18E11_34410	COG4535	Mg2 and Co2 transporter CorC
WP2W18E11_34430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2W18E11_34470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WP2W18E11_34490	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WP2W18E11_34510	COG0484	heat shock protein binding
WP2W18E11_34520	COG0789	Transcriptional regulator
WP2W18E11_34530	COG0598	Magnesium transport protein CorA
WP2W18E11_34540	COG1185	polyribonucleotide nucleotidyltransferase activity
WP2W18E11_34570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP2W18E11_34580	COG1074	ATP-dependent DNA helicase activity
WP2W18E11_34590	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
WP2W18E11_34630	COG2226	methyltransferase
WP2W18E11_34650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WP2W18E11_34680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WP2W18E11_34710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WP2W18E11_34710	COG2111	Na H antiporter
WP2W18E11_34720	COG1006	Multisubunit Na H antiporter MnhC subunit
WP2W18E11_34730	COG0651	ATP synthesis coupled electron transport
WP2W18E11_34750	COG2212	antiporter activity
WP2W18E11_34770	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WP2W18E11_34790	COG0195	Participates in both transcription termination and antitermination
WP2W18E11_34860	COG0237	dephospho-CoA kinase activity
WP2W18E11_34880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP2W18E11_34910	COG0497	DNA recombination
WP2W18E11_34930	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WP2W18E11_34990	COG2169	Transcriptional regulator
WP2W18E11_34990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WP2W18E11_35000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WP2W18E11_35130	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
WP2W18E11_35160	COG0326	Molecular chaperone. Has ATPase activity
WP2W18E11_35190	COG2056	Na+-H+ antiporter family
WP2W18E11_35320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP2W18E11_35340	COG0546	phosphoglycolate phosphatase activity
WP2W18E11_35350	COG1716	ATPase activity
WP2W18E11_35440	COG0181	hydroxymethylbilane synthase activity
WP2W18E11_35460	COG3275	phosphorelay sensor kinase activity
WP2W18E11_35500	COG1538	Outer membrane efflux protein
WP2W18E11_35510	COG0697	spore germination
WP2W18E11_35550	COG0494	nUDIX hydrolase
WP2W18E11_35560	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
WP2W18E11_35570	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WP2W18E11_35580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP2W18E11_35590	COG0772	Belongs to the SEDS family
WP2W18E11_35640	COG4974	Belongs to the 'phage' integrase family
WP2W18E11_35650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP2W18E11_35670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP2W18E11_35690	COG2197	response regulator
WP2W18E11_35720	COG0793	Belongs to the peptidase S41A family
WP2W18E11_35730	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WP2W18E11_35740	COG0795	lipopolysaccharide-transporting ATPase activity
WP2W18E11_35820	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP2W18E11_35820	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP2W18E11_35840	COG0004	ammonium transporteR
WP2W18E11_35850	COG0347	Belongs to the P(II) protein family
WP2W18E11_35870	COG0606	chelatase, subunit chli
WP2W18E11_35880	COG0431	NADPH-dependent FMN reductase
WP2W18E11_35890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP2W18E11_35900	COG0235	Class ii aldolase
WP2W18E11_35910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP2W18E11_35950	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WP2W18E11_35980	COG0318	PFAM AMP-dependent synthetase and ligase
WP2W18E11_36000	COG0477	Major facilitator Superfamily
WP2W18E11_36010	COG2860	membrane
WP2W18E11_36030	COG1253	flavin adenine dinucleotide binding
WP2W18E11_36050	COG2814	Major facilitator Superfamily
WP2W18E11_36070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP2W18E11_36140	COG0655	NAD(P)H dehydrogenase (quinone) activity
WP2W18E11_36170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WP2W18E11_36180	COG1309	transcriptional regulator
WP2W18E11_36250	COG0758	DNA mediated transformation
WP2W18E11_36270	COG0697	spore germination
WP2W18E11_36280	COG1309	transcriptional regulator
WP2W18E11_36310	COG0386	Belongs to the glutathione peroxidase family
WP2W18E11_36340	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WP2W18E11_36360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WP2W18E11_36440	COG1121	(ABC) transporter
WP2W18E11_36450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WP2W18E11_36460	COG1280	lysine exporter protein (LysE YggA)
WP2W18E11_36470	COG2837	iron assimilation
WP2W18E11_36480	COG0281	malic enzyme
WP2W18E11_36570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP2W18E11_36570	COG0519	Catalyzes the synthesis of GMP from XMP
WP2W18E11_36580	COG4399	Belongs to the UPF0754 family
WP2W18E11_36590	COG2259	Doxx family
WP2W18E11_36600	COG0586	Pfam SNARE associated Golgi protein
WP2W18E11_36630	COG1192	Involved in chromosome partitioning
WP2W18E11_36650	COG0271	Belongs to the BolA IbaG family
WP2W18E11_36710	COG3321	synthase
WP2W18E11_36710	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
WP2W18E11_36710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP2W18E11_36710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WP2W18E11_36720	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_36730	COG0318	PFAM AMP-dependent synthetase and ligase
WP2W18E11_36740	COG2197	response regulator
WP2W18E11_36760	COG3916	Acyl-homoserine-lactone synthase
WP2W18E11_36770	COG0477	Major facilitator Superfamily
WP2W18E11_36780	COG1024	Enoyl-CoA hydratase
WP2W18E11_36790	COG1024	Enoyl-CoA hydratase
WP2W18E11_36800	COG1960	acyl-CoA dehydrogenase activity
WP2W18E11_36810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP2W18E11_36850	COG1113	amino acid transport
WP2W18E11_36860	COG1113	amino acid transport
WP2W18E11_36870	COG0251	oxidation-reduction process
WP2W18E11_36950	COG0564	pseudouridine synthase activity
WP2W18E11_37070	COG1051	belongs to the nudix hydrolase family
WP2W18E11_37150	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WP2W18E11_37180	COG1802	Transcriptional regulator
WP2W18E11_37190	COG1448	Aminotransferase
WP2W18E11_37200	COG0277	FAD linked oxidase domain protein
WP2W18E11_37220	COG2186	Transcriptional regulator
WP2W18E11_37240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WP2W18E11_37270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WP2W18E11_37280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WP2W18E11_37350	COG1091	dTDP-4-dehydrorhamnose reductase activity
WP2W18E11_37400	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WP2W18E11_37460	COG0728	peptidoglycan biosynthetic process
WP2W18E11_37470	COG3023	N-Acetylmuramoyl-L-alanine amidase
WP2W18E11_37580	COG0546	phosphoglycolate phosphatase activity
WP2W18E11_37590	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18E11_37620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP2W18E11_37620	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
WP2W18E11_37630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WP2W18E11_37640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WP2W18E11_37650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WP2W18E11_37660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WP2W18E11_37670	COG1116	anion transmembrane transporter activity
WP2W18E11_37680	COG1309	transcriptional regulator
WP2W18E11_37690	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WP2W18E11_37710	COG0196	riboflavin kinase activity
WP2W18E11_37720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WP2W18E11_37740	COG1047	Peptidyl-prolyl cis-trans
WP2W18E11_37770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP2W18E11_37820	COG0583	DNA-binding transcription factor activity
WP2W18E11_37880	COG2951	lytic endotransglycosylase activity
WP2W18E11_37890	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WP2W18E11_37920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP2W18E11_37940	COG0671	phosphoesterase, PA-phosphatase related
WP2W18E11_37950	COG0861	Integral membrane protein TerC family
WP2W18E11_37970	COG0754	glutathionylspermidine amidase activity
WP2W18E11_37990	COG0402	S-adenosylhomocysteine deaminase activity
WP2W18E11_38020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP2W18E11_38030	COG1230	cation diffusion facilitator family transporter
WP2W18E11_38060	COG0706	membrane insertase activity
WP2W18E11_P10080	COG3077	Addiction module antitoxin, RelB DinJ family
WP2W18E11_P10140	COG4221	oxidoreductase activity
WP2W18E11_P10150	COG0583	DNA-binding transcription factor activity
WP2W18E11_P10160	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
WP2W18E11_P10190	COG0697	spore germination
WP2W18E11_P10200	COG0477	Major facilitator Superfamily
WP2W18E11_P10250	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
WP2W18E11_P10270	COG1979	alcohol dehydrogenase
WP2W18E11_P10290	COG1902	pentaerythritol trinitrate reductase activity
WP2W18E11_P10310	COG1309	transcriptional regulator
WP2W18E11_P10320	COG2130	NADP-dependent
WP2W18E11_P10350	COG0582	viral genome integration into host DNA
WP2W18E11_P10430	COG2207	Transcriptional regulator
WP2W18E11_P10440	COG0633	Ferredoxin
WP2W18E11_P10490	COG1309	transcriptional regulator
WP2W18E11_P10560	COG1373	ATPase (AAA superfamily
WP2W18E11_P10640	COG3038	cytochrome b561
WP2W18E11_P10870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair