locus-tag	class	description
LDO52_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LDO52_00010	COG0592	DNA-directed DNA polymerase activity
LDO52_00020	COG0187	DNA topoisomerase II activity
LDO52_00025	COG1063	alcohol dehydrogenase
LDO52_00030	COG0488	(ABC) transporter
LDO52_00085	COG0657	acetylesterase activity
LDO52_00095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LDO52_00130	COG2814	Major facilitator Superfamily
LDO52_00135	COG2814	Major facilitator Superfamily
LDO52_00150	COG0666	response to abiotic stimulus
LDO52_00155	COG0693	protein deglycase activity
LDO52_00165	COG1012	belongs to the aldehyde dehydrogenase family
LDO52_00170	COG0733	neurotransmitter:sodium symporter activity
LDO52_00180	COG0428	transporter
LDO52_00200	COG0129	dihydroxy-acid dehydratase activity
LDO52_00205	COG0675	Transposase, IS605 OrfB family
LDO52_00225	COG2233	PERMEase
LDO52_00235	COG1309	transcriptional regulator
LDO52_00240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDO52_00260	COG2801	Transposase and inactivated derivatives
LDO52_00275	COG0463	Glycosyl transferase, family 2
LDO52_00280	COG2246	polysaccharide biosynthetic process
LDO52_00295	COG1064	alcohol dehydrogenase
LDO52_00300	COG2818	Glycosylase
LDO52_00310	COG0739	heme binding
LDO52_00360	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LDO52_00375	COG0463	Glycosyl transferase, family 2
LDO52_00385	COG1215	transferase activity, transferring glycosyl groups
LDO52_00395	COG0438	transferase activity, transferring glycosyl groups
LDO52_00405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LDO52_00415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LDO52_00425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LDO52_00440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LDO52_00445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDO52_00450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LDO52_00460	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LDO52_00465	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LDO52_00475	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LDO52_00495	COG0281	malic enzyme
LDO52_00500	COG4628	conserved protein (DUF2132)
LDO52_00535	COG0271	Belongs to the BolA IbaG family
LDO52_00545	COG1192	Involved in chromosome partitioning
LDO52_00560	COG0586	Pfam SNARE associated Golgi protein
LDO52_00565	COG3111	PFAM Bacterial OB fold (BOF) protein
LDO52_00570	COG0519	Catalyzes the synthesis of GMP from XMP
LDO52_00570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LDO52_00610	COG0534	Mate efflux family protein
LDO52_00615	COG0436	Aminotransferase
LDO52_00635	COG2837	iron assimilation
LDO52_00640	COG1280	lysine exporter protein (LysE YggA)
LDO52_00645	COG1683	Conserved Protein
LDO52_00650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LDO52_00655	COG1121	(ABC) transporter
LDO52_00705	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LDO52_00720	COG1012	belongs to the aldehyde dehydrogenase family
LDO52_00735	COG0386	Belongs to the glutathione peroxidase family
LDO52_00740	COG0697	spore germination
LDO52_00750	COG0758	DNA mediated transformation
LDO52_00800	COG2814	Major facilitator Superfamily
LDO52_00825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LDO52_00860	COG1253	flavin adenine dinucleotide binding
LDO52_00870	COG2860	membrane
LDO52_00875	COG0477	Major facilitator Superfamily
LDO52_00885	COG0318	PFAM AMP-dependent synthetase and ligase
LDO52_00900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LDO52_00915	COG0606	chelatase, subunit chli
LDO52_00925	COG0347	Belongs to the P(II) protein family
LDO52_00930	COG0004	ammonium transporteR
LDO52_00940	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LDO52_00940	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LDO52_00955	COG0586	Pfam SNARE associated Golgi protein
LDO52_00975	COG0795	lipopolysaccharide-transporting ATPase activity
LDO52_00980	COG0795	lipopolysaccharide-transporting ATPase activity
LDO52_00985	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LDO52_00990	COG0793	Belongs to the peptidase S41A family
LDO52_01000	COG3852	Histidine kinase
LDO52_01005	COG2197	response regulator
LDO52_01015	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LDO52_01025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LDO52_01030	COG4974	Belongs to the 'phage' integrase family
LDO52_01055	COG0772	Belongs to the SEDS family
LDO52_01065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDO52_01070	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LDO52_01080	COG0494	nUDIX hydrolase
LDO52_01095	COG1538	Outer membrane efflux protein
LDO52_01105	COG1132	(ABC) transporter
LDO52_01115	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LDO52_01125	COG0497	DNA recombination
LDO52_01130	COG3123	guanosine phosphorylase activity
LDO52_01135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDO52_01145	COG0237	dephospho-CoA kinase activity
LDO52_01150	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LDO52_01170	COG0149	triose-phosphate isomerase activity
LDO52_01205	COG0779	Required for maturation of 30S ribosomal subunits
LDO52_01210	COG0195	Participates in both transcription termination and antitermination
LDO52_01215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LDO52_01220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LDO52_01225	COG1320	monovalent cation:proton antiporter activity
LDO52_01230	COG2212	antiporter activity
LDO52_01235	COG1863	multisubunit Na H antiporter MnhE subunit
LDO52_01240	COG0651	ATP synthesis coupled electron transport
LDO52_01245	COG1006	Multisubunit Na H antiporter MnhC subunit
LDO52_01250	COG2111	Na H antiporter
LDO52_01250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LDO52_01265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LDO52_01270	COG4221	oxidoreductase activity
LDO52_01280	COG0488	(ABC) transporter
LDO52_01300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDO52_01335	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LDO52_01355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LDO52_01360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LDO52_01365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LDO52_01370	COG2226	methyltransferase
LDO52_01425	COG0069	glutamate synthase activity
LDO52_01425	COG0070	glutamate synthase
LDO52_01425	COG0067	glutamate synthase
LDO52_01430	COG0493	'glutamate synthase
LDO52_01435	COG1704	LemA family
LDO52_01470	COG4372	Transposase
LDO52_01530	COG3307	-O-antigen
LDO52_01550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LDO52_01555	COG1758	RNA polymerase activity
LDO52_01560	COG0194	GDP metabolic process
LDO52_01570	COG4969	Belongs to the N-Me-Phe pilin family
LDO52_01605	COG0228	four-way junction DNA binding
LDO52_01610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LDO52_01620	COG0335	large ribosomal subunit rRNA binding
LDO52_01625	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LDO52_01635	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LDO52_01640	COG5380	lipid catabolic process
LDO52_01645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LDO52_01675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDO52_01685	COG0277	FAD linked oxidase domain protein
LDO52_01730	COG2814	Major facilitator Superfamily
LDO52_01740	COG0628	permease
LDO52_01745	COG1192	Involved in chromosome partitioning
LDO52_01760	COG2226	methyltransferase
LDO52_01775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LDO52_01785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LDO52_01795	COG0534	Mate efflux family protein
LDO52_01805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LDO52_01810	COG1278	Cold shock
LDO52_01815	COG1960	acyl-CoA dehydrogenase activity
LDO52_01830	COG0408	coproporphyrinogen oxidase activity
LDO52_01835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LDO52_01860	COG0513	Belongs to the DEAD box helicase family
LDO52_01865	COG1127	ABC transporter
LDO52_01870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LDO52_01875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LDO52_01880	COG2854	intermembrane phospholipid transfer
LDO52_01890	COG0598	Magnesium transport protein CorA
LDO52_01900	COG0494	nUDIX hydrolase
LDO52_01905	COG1040	competence protein
LDO52_01910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LDO52_01920	COG2937	Belongs to the GPAT DAPAT family
LDO52_01925	COG1946	Acyl-CoA thioesterase
LDO52_01930	COG1301	dicarboxylic acid transport
LDO52_01945	COG1959	2 iron, 2 sulfur cluster binding
LDO52_01955	COG0626	cystathionine gamma-synthase activity
LDO52_01975	COG0088	Forms part of the polypeptide exit tunnel
LDO52_01980	COG0089	rRNA binding
LDO52_01990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LDO52_02040	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LDO52_02045	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LDO52_02055	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LDO52_02080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LDO52_02090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LDO52_02095	COG0202	RNA polymerase activity
LDO52_02100	COG0203	ribosomal protein L17
LDO52_02105	COG2072	flavoprotein involved in K transport
LDO52_02110	COG1960	acyl-CoA dehydrogenase activity
LDO52_02115	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LDO52_02150	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LDO52_02155	COG0339	signal peptide processing
LDO52_02165	COG0557	exoribonuclease II activity
LDO52_02200	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDO52_02215	COG1295	ribonuclease BN
LDO52_02265	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LDO52_02270	COG1702	phosphate starvation-inducible protein PhoH
LDO52_02275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LDO52_02280	COG0741	lytic transglycosylase activity
LDO52_02280	COG1196	nuclear chromosome segregation
LDO52_02280	COG0739	heme binding
LDO52_02320	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LDO52_02325	COG1183	phosphatidylcholine synthase activity
LDO52_02370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDO52_02400	COG1607	acyl-coa hydrolase
LDO52_02410	COG1666	GTP binding
LDO52_02430	COG2350	Protein conserved in bacteria
LDO52_02445	COG3781	membrane
LDO52_02450	COG2003	Belongs to the UPF0758 family
LDO52_02455	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LDO52_02465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LDO52_02475	COG2814	Major facilitator Superfamily
LDO52_02500	COG3622	Belongs to the hyi family
LDO52_02505	COG2084	Dehydrogenase
LDO52_02535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LDO52_02545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDO52_02555	COG1862	Preprotein translocase
LDO52_02570	COG1704	LemA family
LDO52_02580	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LDO52_02630	COG0285	dihydrofolate synthase activity
LDO52_02640	COG0450	alkyl hydroperoxide reductase
LDO52_02645	COG0653	protein targeting
LDO52_02655	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LDO52_02660	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LDO52_02715	COG2969	positive regulation of protein catabolic process
LDO52_02720	COG0625	glutathione transferase activity
LDO52_02725	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LDO52_02730	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LDO52_02740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LDO52_02745	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LDO52_02785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LDO52_02795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LDO52_02800	COG1408	metallophosphoesterase
LDO52_02810	COG0477	Major facilitator Superfamily
LDO52_02815	COG1272	protein, Hemolysin III
LDO52_02835	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO52_02835	COG1024	Enoyl-CoA hydratase
LDO52_02840	COG0183	Belongs to the thiolase family
LDO52_02845	COG2207	Transcriptional regulator
LDO52_02850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO52_02855	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LDO52_02870	COG0183	Belongs to the thiolase family
LDO52_02875	COG4969	Belongs to the N-Me-Phe pilin family
LDO52_02890	COG0833	amino acid
LDO52_02900	COG2233	PERMEase
LDO52_02905	COG1217	gtp-binding protein TYPA
LDO52_02915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LDO52_02930	COG1902	pentaerythritol trinitrate reductase activity
LDO52_02955	COG0354	folic acid binding
LDO52_03005	COG0564	pseudouridine synthase activity
LDO52_03035	COG2824	Alkylphosphonate utilization operon protein PhnA
LDO52_03060	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LDO52_03060	COG0352	thiamine-phosphate diphosphorylase activity
LDO52_03060	COG0351	phosphomethylpyrimidine kinase
LDO52_03075	COG3152	Membrane
LDO52_03085	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LDO52_03095	COG0745	RESPONSE REGULATOR receiver
LDO52_03100	COG2205	protein histidine kinase activity
LDO52_03110	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDO52_03130	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LDO52_03145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDO52_03155	COG0713	ATP synthesis coupled electron transport
LDO52_03160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LDO52_03165	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDO52_03190	COG1278	Cold shock
LDO52_03195	COG0583	DNA-binding transcription factor activity
LDO52_03205	COG1126	abc transporter atp-binding protein
LDO52_03210	COG0765	amino acid transport
LDO52_03215	COG0765	amino acid transport
LDO52_03240	COG0668	transmembrane transport
LDO52_03255	COG2081	HI0933 family
LDO52_03265	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LDO52_03300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDO52_03300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDO52_03315	COG0489	protein tyrosine kinase activity
LDO52_03360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDO52_03385	COG0840	transmembrane signaling receptor activity
LDO52_03415	COG2832	Protein of unknown function (DUF454)
LDO52_03475	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LDO52_03485	COG1289	transmembrane transporter activity
LDO52_03490	COG2814	Major facilitator Superfamily
LDO52_03500	COG0786	glutamate:sodium symporter activity
LDO52_03505	COG1115	amino acid carrier protein
LDO52_03510	COG2059	Chromate
LDO52_03515	COG1752	Esterase of the alpha-beta hydrolase superfamily
LDO52_03525	COG1607	acyl-coa hydrolase
LDO52_03535	COG2814	Major facilitator Superfamily
LDO52_03540	COG0583	DNA-binding transcription factor activity
LDO52_03560	COG0523	cobalamin synthesis protein
LDO52_03565	COG4681	YaeQ
LDO52_03580	COG4251	negative regulation of phosphorylation
LDO52_03580	COG5001	Diguanylate cyclase
LDO52_03580	COG3706	GGDEF domain
LDO52_03580	COG2203	Gaf domain
LDO52_03610	COG0393	Putative heavy-metal-binding
LDO52_03615	COG0393	Putative heavy-metal-binding
LDO52_03620	COG1538	Outer membrane efflux protein
LDO52_03630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDO52_03635	COG0671	phosphoesterase, PA-phosphatase related
LDO52_03650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LDO52_03655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LDO52_03660	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LDO52_03680	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LDO52_03685	COG1648	precorrin-2 dehydrogenase activity
LDO52_03685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LDO52_03690	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LDO52_03700	COG0531	amino acid
LDO52_03715	COG0321	lipoyl(octanoyl) transferase activity
LDO52_03720	COG2921	Belongs to the UPF0250 family
LDO52_03725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LDO52_03745	COG0586	Pfam SNARE associated Golgi protein
LDO52_03790	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LDO52_03795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LDO52_03825	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LDO52_03840	COG0358	DNA primase activity
LDO52_03850	COG0564	pseudouridine synthase activity
LDO52_03875	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LDO52_03895	COG0110	maltose O-acetyltransferase activity
LDO52_03900	COG0251	oxidation-reduction process
LDO52_03905	COG1309	transcriptional regulator
LDO52_03915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LDO52_03920	COG0505	Belongs to the CarA family
LDO52_03950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDO52_03955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LDO52_03990	COG1253	flavin adenine dinucleotide binding
LDO52_04010	COG2239	Acts as a magnesium transporter
LDO52_04020	COG0501	Belongs to the peptidase M48B family
LDO52_04025	COG1196	nuclear chromosome segregation
LDO52_04025	COG0741	lytic transglycosylase activity
LDO52_04025	COG0739	heme binding
LDO52_04030	COG0037	tRNA processing
LDO52_04040	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LDO52_04045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LDO52_04065	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LDO52_04075	COG0281	malic enzyme
LDO52_04075	COG0280	phosphate acetyltransferase
LDO52_04080	COG5001	Diguanylate cyclase
LDO52_04080	COG1716	ATPase activity
LDO52_04085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LDO52_04090	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LDO52_04095	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LDO52_04145	COG1115	amino acid carrier protein
LDO52_04150	COG1113	amino acid transport
LDO52_04160	COG0019	diaminopimelate decarboxylase activity
LDO52_04175	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LDO52_04185	COG1522	sequence-specific DNA binding
LDO52_04190	COG1280	lysine exporter protein (LysE YggA)
LDO52_04225	COG0842	Transport permease protein
LDO52_04230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDO52_04250	COG1671	Belongs to the UPF0178 family
LDO52_04270	COG1136	(ABC) transporter
LDO52_04275	COG2333	competence protein COMEC
LDO52_04275	COG0658	competence protein
LDO52_04290	COG2267	carboxylic ester hydrolase activity
LDO52_04295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LDO52_04305	COG0628	permease
LDO52_04310	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LDO52_04340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDO52_04355	COG2885	chlorophyll binding
LDO52_04360	COG0823	Involved in the tonB-independent uptake of proteins
LDO52_04380	COG0824	Thioesterase
LDO52_04385	COG1473	amidohydrolase
LDO52_04400	COG2255	four-way junction helicase activity
LDO52_04425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LDO52_04425	COG0047	phosphoribosylformylglycinamidine synthase activity
LDO52_04440	COG0583	DNA-binding transcription factor activity
LDO52_04450	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
LDO52_04455	COG0778	Nitroreductase
LDO52_04460	COG1024	Enoyl-CoA hydratase
LDO52_04465	COG1051	belongs to the nudix hydrolase family
LDO52_04465	COG1056	cytidyltransferase-related domain
LDO52_04470	COG0583	DNA-binding transcription factor activity
LDO52_04485	COG2353	YceI-like domain
LDO52_04490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LDO52_04500	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LDO52_04505	COG0602	queuosine metabolic process
LDO52_04525	COG0583	DNA-binding transcription factor activity
LDO52_04530	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LDO52_04535	COG4208	sulfate ABC transporter
LDO52_04550	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LDO52_04555	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LDO52_04565	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LDO52_04635	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
LDO52_04660	COG0640	Transcriptional regulator
LDO52_04670	COG0798	PFAM Bile acid sodium symporter
LDO52_04675	COG0431	NADPH-dependent FMN reductase
LDO52_04720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDO52_04745	COG0571	ribonuclease III activity
LDO52_04750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LDO52_04760	COG1381	Involved in DNA repair and RecF pathway recombination
LDO52_04765	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LDO52_04795	COG0436	Aminotransferase
LDO52_04805	COG0052	Belongs to the universal ribosomal protein uS2 family
LDO52_04830	COG2951	lytic endotransglycosylase activity
LDO52_04845	COG0842	Transport permease protein
LDO52_04850	COG1131	(ABC) transporter
LDO52_04860	COG0583	DNA-binding transcription factor activity
LDO52_04895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LDO52_04915	COG3634	alkyl hydroperoxide reductase activity
LDO52_04920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LDO52_04925	COG0826	peptidase U32
LDO52_04955	COG1720	tRNA m6t6A37 methyltransferase activity
LDO52_04965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LDO52_04990	COG0494	nUDIX hydrolase
LDO52_05000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDO52_05005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LDO52_05010	COG3139	Protein of unknown function (DUF1315)
LDO52_05020	COG1301	dicarboxylic acid transport
LDO52_05025	COG1960	acyl-CoA dehydrogenase activity
LDO52_05030	COG0693	protein deglycase activity
LDO52_05040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LDO52_05045	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LDO52_05075	COG2252	PERMEase
LDO52_05080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LDO52_05100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LDO52_05110	COG0527	aspartate kinase activity
LDO52_05115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LDO52_05120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LDO52_05135	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LDO52_05150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LDO52_05170	COG1252	NADH dehydrogenase
LDO52_05175	COG1686	Belongs to the peptidase S11 family
LDO52_05190	COG2351	hydroxyisourate hydrolase activity
LDO52_05210	COG1187	pseudouridine synthase activity
LDO52_05230	COG0436	Aminotransferase
LDO52_05235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDO52_05240	COG0386	Belongs to the glutathione peroxidase family
LDO52_05250	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LDO52_05265	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LDO52_05275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LDO52_05280	COG0012	GTP binding
LDO52_05305	COG0204	Acyl-transferase
LDO52_05360	COG4372	Transposase
LDO52_05430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LDO52_05445	COG4245	von Willebrand factor, type A
LDO52_05465	COG1136	(ABC) transporter
LDO52_05525	COG3177	Filamentation induced by cAMP protein fic
LDO52_05530	COG0582	viral genome integration into host DNA
LDO52_05560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LDO52_05560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LDO52_05565	COG1254	Belongs to the acylphosphatase family
LDO52_05595	COG3634	alkyl hydroperoxide reductase activity
LDO52_05620	COG1643	Atp-dependent helicase
LDO52_05640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LDO52_05650	COG2707	UPF0756 membrane protein
LDO52_05675	COG0802	atpase or kinase
LDO52_05680	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LDO52_05690	COG1923	regulation of RNA biosynthetic process
LDO52_05695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LDO52_05705	COG3178	'Phosphotransferase
LDO52_05710	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LDO52_05720	COG1192	Involved in chromosome partitioning
LDO52_05725	COG1475	DNA binding
LDO52_05730	COG0811	peptide transport
LDO52_05740	COG1132	(ABC) transporter
LDO52_05745	COG1663	tetraacyldisaccharide 4'-kinase activity
LDO52_05765	COG0084	hydrolase, TatD family'
LDO52_05770	COG1309	transcriptional regulator
LDO52_05800	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LDO52_05830	COG0776	regulation of translation
LDO52_05850	COG2431	L-lysine efflux transmembrane transporter activity
LDO52_05865	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LDO52_05870	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LDO52_05890	COG1253	flavin adenine dinucleotide binding
LDO52_05910	COG0308	aminopeptidase N
LDO52_05920	COG0589	response to stress
LDO52_05925	COG0589	response to stress
LDO52_05940	COG3135	benzoate transporter
LDO52_05950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LDO52_05955	COG0583	DNA-binding transcription factor activity
LDO52_05970	COG0183	Belongs to the thiolase family
LDO52_05985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LDO52_06000	COG0824	Thioesterase
LDO52_06005	COG1454	alcohol dehydrogenase
LDO52_06010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDO52_06030	COG0069	glutamate synthase activity
LDO52_06040	COG2308	Evidence 4 Homologs of previously reported genes of
LDO52_06050	COG1305	Transglutaminase-like
LDO52_06065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LDO52_06070	COG0305	Participates in initiation and elongation during chromosome replication
LDO52_06085	COG0360	Binds together with S18 to 16S ribosomal RNA
LDO52_06095	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LDO52_06100	COG1845	cytochrome c oxidase, subunit III
LDO52_06105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LDO52_06110	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LDO52_06135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO52_06150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LDO52_06155	COG2890	protein-(glutamine-N5) methyltransferase activity
LDO52_06175	COG1960	acyl-CoA dehydrogenase activity
LDO52_06180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO52_06190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LDO52_06225	COG0477	Major facilitator Superfamily
LDO52_06230	COG0729	surface antigen
LDO52_06255	COG1570	exodeoxyribonuclease VII activity
LDO52_06295	COG0786	glutamate:sodium symporter activity
LDO52_06315	COG1114	Component of the transport system for branched-chain amino acids
LDO52_06325	COG0583	DNA-binding transcription factor activity
LDO52_06335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LDO52_06370	COG1902	pentaerythritol trinitrate reductase activity
LDO52_06370	COG0446	pyridine nucleotide-disulphide oxidoreductase
LDO52_06400	COG0148	phosphopyruvate hydratase activity
LDO52_06415	COG0772	Belongs to the SEDS family
LDO52_06425	COG4890	Cyd operon protein YbgT
LDO52_06430	COG1294	oxidase, subunit
LDO52_06480	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LDO52_06500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDO52_06510	COG0133	tryptophan synthase activity
LDO52_06515	COG0517	IMP dehydrogenase activity
LDO52_06515	COG0617	tRNA 3'-terminal CCA addition
LDO52_06515	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LDO52_06545	COG0612	Peptidase, M16
LDO52_06550	COG0552	protein localization to endoplasmic reticulum
LDO52_06615	COG1960	acyl-CoA dehydrogenase activity
LDO52_06680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LDO52_06685	COG0730	response to heat
LDO52_06690	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LDO52_06695	COG2207	Transcriptional regulator
LDO52_06700	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LDO52_06705	COG1960	acyl-CoA dehydrogenase activity
LDO52_06710	COG2169	Transcriptional regulator
LDO52_06715	COG2814	Major facilitator Superfamily
LDO52_06725	COG1271	oxidase subunit
LDO52_06730	COG1294	oxidase, subunit
LDO52_06740	COG1525	nuclease
LDO52_06800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LDO52_06805	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LDO52_06815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LDO52_06825	COG2814	Major facilitator Superfamily
LDO52_06830	COG0509	glycine decarboxylation via glycine cleavage system
LDO52_06845	COG1132	(ABC) transporter
LDO52_06855	COG0668	transmembrane transport
LDO52_06860	COG3122	Protein conserved in bacteria
LDO52_06880	COG0640	Transcriptional regulator
LDO52_06885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LDO52_06895	COG0789	Transcriptional regulator
LDO52_06910	COG1960	acyl-CoA dehydrogenase activity
LDO52_06915	COG0183	Belongs to the thiolase family
LDO52_06920	COG0427	acetyl-CoA hydrolase
LDO52_06940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDO52_06945	COG0183	Belongs to the thiolase family
LDO52_06950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LDO52_06955	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LDO52_06960	COG3135	benzoate transporter
LDO52_06965	COG1028	Short-chain dehydrogenase reductase Sdr
LDO52_06970	COG0543	2 iron, 2 sulfur cluster binding
LDO52_06970	COG0633	Ferredoxin
LDO52_06975	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LDO52_06980	COG4638	Rieske (2fe-2S)
LDO52_06990	COG4829	muconolactone delta-isomerase
LDO52_06995	COG4948	Mandelate Racemase Muconate Lactonizing
LDO52_07000	COG0583	DNA-binding transcription factor activity
LDO52_07005	COG2814	Major facilitator Superfamily
LDO52_07015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDO52_07020	COG0318	PFAM AMP-dependent synthetase and ligase
LDO52_07030	COG1017	nitric oxide dioxygenase activity
LDO52_07030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO52_07045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDO52_07055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LDO52_07055	COG1116	anion transmembrane transporter activity
LDO52_07065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LDO52_07070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LDO52_07075	COG2116	formate transmembrane transporter activity
LDO52_07080	COG0515	serine threonine protein kinase
LDO52_07095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LDO52_07100	COG1309	transcriptional regulator
LDO52_07105	COG1012	belongs to the aldehyde dehydrogenase family
LDO52_07120	COG1944	ATP diphosphatase activity
LDO52_07125	COG0644	oxidoreductase
LDO52_07125	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LDO52_07135	COG1960	acyl-CoA dehydrogenase activity
LDO52_07140	COG1960	acyl-CoA dehydrogenase activity
LDO52_07145	COG2814	Major facilitator Superfamily
LDO52_07150	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LDO52_07155	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LDO52_07170	COG2814	Major facilitator Superfamily
LDO52_07180	COG2814	Major facilitator Superfamily
LDO52_07185	COG1024	Enoyl-CoA hydratase
LDO52_07190	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO52_07195	COG0183	Belongs to the thiolase family
LDO52_07205	COG0235	Class ii aldolase
LDO52_07210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDO52_07215	COG1024	Enoyl-CoA hydratase
LDO52_07225	COG1960	acyl-CoA dehydrogenase activity
LDO52_07230	COG0596	Alpha beta hydrolase
LDO52_07230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDO52_07230	COG2226	methyltransferase
LDO52_07240	COG0318	PFAM AMP-dependent synthetase and ligase
LDO52_07245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO52_07250	COG2814	Major facilitator Superfamily
LDO52_07260	COG1028	Short-chain dehydrogenase reductase Sdr
LDO52_07265	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LDO52_07275	COG0318	PFAM AMP-dependent synthetase and ligase
LDO52_07285	COG0583	DNA-binding transcription factor activity
LDO52_07300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO52_07305	COG1960	acyl-CoA dehydrogenase activity
LDO52_07310	COG1024	Enoyl-CoA hydratase
LDO52_07325	COG1028	Short-chain dehydrogenase reductase Sdr
LDO52_07335	COG2801	Transposase and inactivated derivatives
LDO52_07340	COG2885	chlorophyll binding
LDO52_07340	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LDO52_07350	COG0596	Alpha beta hydrolase
LDO52_07430	COG0741	lytic transglycosylase activity
LDO52_07430	COG1196	nuclear chromosome segregation
LDO52_07430	COG0739	heme binding
LDO52_07460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LDO52_07480	COG3646	Phage regulatory protein
LDO52_07550	COG5410	chromosome segregation
LDO52_07710	COG0582	viral genome integration into host DNA
LDO52_07720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LDO52_07755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LDO52_07770	COG0439	Biotin carboxylase
LDO52_07790	COG2814	Major facilitator Superfamily
LDO52_07820	COG4680	protein conserved in bacteria
LDO52_07860	COG0372	Belongs to the citrate synthase family
LDO52_07890	COG0542	response to heat
LDO52_07895	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LDO52_07915	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LDO52_07920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LDO52_07925	COG0569	domain protein
LDO52_07930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LDO52_07950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDO52_07960	COG1585	Membrane protein implicated in regulation of membrane protease activity
LDO52_07980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LDO52_08010	COG0822	iron-sulfur transferase activity
LDO52_08015	COG0316	Belongs to the HesB IscA family
LDO52_08045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LDO52_08055	COG1027	Aspartate ammonia-lyase
LDO52_08060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDO52_08075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LDO52_08090	COG3781	membrane
LDO52_08115	COG0778	Nitroreductase
LDO52_08125	COG0697	spore germination
LDO52_08150	COG0424	maF-like protein
LDO52_08155	COG2850	peptidyl-arginine hydroxylation
LDO52_08160	COG4585	Histidine kinase
LDO52_08165	COG2197	response regulator
LDO52_08175	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LDO52_08180	COG0702	epimerase
LDO52_08205	COG1011	Hydrolase
LDO52_08210	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LDO52_08215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LDO52_08220	COG2137	regulation of response to DNA damage stimulus
LDO52_08235	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LDO52_08240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LDO52_08255	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LDO52_08270	COG0575	Belongs to the CDS family
LDO52_08275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LDO52_08295	COG3852	Histidine kinase
LDO52_08310	COG2814	Major facilitator Superfamily
LDO52_08320	COG2814	Major facilitator Superfamily
LDO52_08355	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LDO52_08360	COG0138	bifunctional purine biosynthesis protein purh
LDO52_08365	COG0151	Belongs to the GarS family
LDO52_08370	COG1464	Belongs to the NlpA lipoprotein family
LDO52_08375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LDO52_08380	COG2011	ABC-type metal ion transport system permease component
LDO52_08410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LDO52_08415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LDO52_08425	COG4122	O-methyltransferase activity
LDO52_08460	COG1137	ATPase activity
LDO52_08465	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LDO52_08475	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LDO52_08480	COG0517	IMP dehydrogenase activity
LDO52_08480	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LDO52_08510	COG0625	glutathione transferase activity
LDO52_08515	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LDO52_08515	COG0519	Catalyzes the synthesis of GMP from XMP
LDO52_08525	COG2353	YceI-like domain
LDO52_08540	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LDO52_08550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LDO52_08580	COG2070	2-Nitropropane dioxygenase
LDO52_08590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LDO52_08615	COG1309	transcriptional regulator
LDO52_08660	COG0564	pseudouridine synthase activity
LDO52_08685	COG0352	thiamine-phosphate diphosphorylase activity
LDO52_08700	COG3025	triphosphatase activity
LDO52_08720	COG0612	Peptidase, M16
LDO52_08780	COG0515	serine threonine protein kinase
LDO52_08805	COG1610	YqeY-like protein
LDO52_08845	COG0167	dihydroorotate dehydrogenase activity
LDO52_08865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LDO52_08870	COG0778	Nitroreductase
LDO52_08880	COG0513	Belongs to the DEAD box helicase family
LDO52_08885	COG1278	Cold shock
LDO52_08900	COG2363	Small membrane protein
LDO52_08920	COG0659	secondary active sulfate transmembrane transporter activity
LDO52_08925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LDO52_08945	COG0318	PFAM AMP-dependent synthetase and ligase
LDO52_08950	COG1309	transcriptional regulator
LDO52_08955	COG1960	acyl-CoA dehydrogenase activity
LDO52_08960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LDO52_08965	COG1024	Enoyl-CoA hydratase
LDO52_08970	COG4770	biotin carboxylase activity
LDO52_08985	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LDO52_08990	COG2031	fatty acid transporter
LDO52_09005	COG0540	Belongs to the ATCase OTCase family
LDO52_09035	COG0667	Aldo Keto reductase
LDO52_09045	COG1765	OsmC-like protein
LDO52_09050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LDO52_09080	COG4372	Transposase
LDO52_09165	COG2755	lipolytic protein G-D-S-L family
LDO52_09165	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LDO52_09220	COG0714	Associated with various cellular activities
LDO52_09225	COG2879	small protein
LDO52_09230	COG1966	Carbon starvation protein
LDO52_09235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LDO52_09240	COG1509	lysine 2,3-aminomutase activity
LDO52_09255	COG0254	rRNA binding
LDO52_09275	COG1067	ATP-dependent peptidase activity
LDO52_09280	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LDO52_09285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LDO52_09290	COG0583	DNA-binding transcription factor activity
LDO52_09300	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LDO52_09315	COG1686	Belongs to the peptidase S11 family
LDO52_09320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LDO52_09345	COG0482	sulfurtransferase activity
LDO52_09375	COG0616	signal peptide processing
LDO52_09385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LDO52_09395	COG0573	inorganic phosphate transmembrane transporter activity
LDO52_09400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LDO52_09405	COG0076	glutamate decarboxylase activity
LDO52_09410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LDO52_09420	COG0671	phosphoesterase, PA-phosphatase related
LDO52_09425	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LDO52_09435	COG2814	Major facilitator Superfamily
LDO52_09445	COG1733	regulation of RNA biosynthetic process
LDO52_09465	COG0556	nucleotide-excision repair
LDO52_09500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDO52_09505	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LDO52_09525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDO52_09530	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LDO52_09535	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LDO52_09575	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LDO52_09590	COG0174	glutamine synthetase
LDO52_09595	COG0512	Glutamine amidotransferase of anthranilate synthase
LDO52_09600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LDO52_09605	COG0134	indole-3-glycerol-phosphate synthase activity
LDO52_09615	COG0302	gtp cyclohydrolase
LDO52_09630	COG3706	GGDEF domain
LDO52_09645	COG3739	integral membrane protein
LDO52_09660	COG1741	Belongs to the pirin family
LDO52_09675	COG0446	pyridine nucleotide-disulphide oxidoreductase
LDO52_09675	COG1902	pentaerythritol trinitrate reductase activity
LDO52_09690	COG3706	GGDEF domain
LDO52_09690	COG5001	Diguanylate cyclase
LDO52_09690	COG4251	negative regulation of phosphorylation
LDO52_09690	COG2203	Gaf domain
LDO52_09695	COG0418	dihydroorotase activity
LDO52_09710	COG4771	TonB-dependent receptor
LDO52_09735	COG0833	amino acid
LDO52_09770	COG4239	(ABC) transporter, permease
LDO52_09775	COG4174	ABC transporter (Permease)
LDO52_09780	COG4166	transmembrane transport
LDO52_09785	COG1388	LysM domain
LDO52_09785	COG0741	lytic transglycosylase activity
LDO52_09790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LDO52_09805	COG0657	acetylesterase activity
LDO52_09820	COG3107	peptidoglycan biosynthetic process
LDO52_09835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDO52_09840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDO52_09845	COG0697	spore germination
LDO52_09850	COG2155	Conserved Protein
LDO52_09855	COG0006	proline dipeptidase activity
LDO52_09895	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LDO52_09905	COG2234	aminopeptidase activity
LDO52_09915	COG3384	dioxygenase
LDO52_09925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LDO52_09930	COG2878	Part of a membrane complex involved in electron transport
LDO52_09935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LDO52_09960	COG0768	penicillin binding
LDO52_09965	COG0742	ribosomal rna small subunit methyltransferase
LDO52_10025	COG0459	protein refolding
LDO52_10040	COG1597	lipid kinase activity
LDO52_10060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LDO52_10085	COG3321	synthase
LDO52_10085	COG0604	alcohol dehydrogenase
LDO52_10085	COG4221	oxidoreductase activity
LDO52_10085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LDO52_10090	COG3118	belongs to the thioredoxin family
LDO52_10105	COG0175	sulfate reduction
LDO52_10120	COG2268	Band 7 protein
LDO52_10125	COG3385	transposase activity
LDO52_10130	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LDO52_10140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDO52_10155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LDO52_10160	COG1053	succinate dehydrogenase
LDO52_10165	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LDO52_10185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LDO52_10185	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LDO52_10200	COG0589	response to stress
LDO52_10220	COG2321	neutral zinc metallopeptidase
LDO52_10225	COG2354	Protein conserved in bacteria
LDO52_10245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LDO52_10250	COG1773	rubredoxin
LDO52_10255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LDO52_10260	COG2267	carboxylic ester hydrolase activity
LDO52_10265	COG0583	DNA-binding transcription factor activity
LDO52_10280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDO52_10290	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LDO52_10295	COG4181	ATPase activity
LDO52_10320	COG4771	TonB-dependent receptor
LDO52_10340	COG0306	phosphate transporter
LDO52_10350	COG0210	DNA helicase
LDO52_10355	COG2376	Dihydroxyacetone kinase
LDO52_10360	COG2066	Belongs to the glutaminase family
LDO52_10365	COG1028	Short-chain dehydrogenase reductase Sdr
LDO52_10375	COG0525	valine-tRNA ligase activity
LDO52_10405	COG2852	Protein conserved in bacteria
LDO52_10425	COG2323	membrane
LDO52_10430	COG0546	phosphoglycolate phosphatase activity
LDO52_10450	COG1752	Esterase of the alpha-beta hydrolase superfamily
LDO52_10465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDO52_10470	COG0142	geranyltranstransferase activity
LDO52_10475	COG2828	Protein conserved in bacteria
LDO52_10480	COG1113	amino acid transport
LDO52_10510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LDO52_10520	COG1530	ribonuclease E activity
LDO52_10525	COG0424	maF-like protein
LDO52_10530	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LDO52_10535	COG1792	Involved in formation and maintenance of cell shape
LDO52_10540	COG1077	Cell shape determining protein MreB Mrl
LDO52_10545	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LDO52_10555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LDO52_10580	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
LDO52_10595	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LDO52_10600	COG2223	nitrite transmembrane transporter activity
LDO52_10610	COG0500	methyltransferase
LDO52_10650	COG0783	Belongs to the Dps family
LDO52_10670	COG1136	(ABC) transporter
LDO52_10675	COG4591	ABC-type transport system involved in lipoprotein release permease component
LDO52_10765	COG4372	Transposase
LDO52_10780	COG1253	flavin adenine dinucleotide binding
LDO52_10795	COG2205	protein histidine kinase activity
LDO52_10800	COG3842	ATPase activity
LDO52_10805	COG1840	ABC-type Fe3 transport system, periplasmic component
LDO52_10825	COG3177	Filamentation induced by cAMP protein fic
LDO52_10840	COG1454	alcohol dehydrogenase
LDO52_10845	COG2610	gluconate transmembrane transporter activity
LDO52_10920	COG0582	viral genome integration into host DNA
LDO52_10930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LDO52_10935	COG2050	protein possibly involved in aromatic compounds catabolism
LDO52_10945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO52_10950	COG1090	epimerase
LDO52_10960	COG0420	3'-5' exonuclease activity
LDO52_10990	COG0735	belongs to the Fur family
LDO52_10995	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LDO52_11000	COG2914	Belongs to the UPF0125 (RnfH) family
LDO52_11015	COG0121	glutamine amidotransferase
LDO52_11020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LDO52_11025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDO52_11030	COG0756	dUTP diphosphatase activity
LDO52_11035	COG0210	DNA helicase
LDO52_11040	COG2885	chlorophyll binding
LDO52_11045	COG0204	Acyl-transferase
LDO52_11055	COG0850	regulation of cytokinetic process
LDO52_11075	COG0531	amino acid
LDO52_11075	COG1674	ftsk spoiiie
LDO52_11080	COG0492	ferredoxin-NADP+ reductase activity
LDO52_11085	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LDO52_11090	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LDO52_11095	COG0456	acetyltransferase
LDO52_11105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LDO52_11110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LDO52_11120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LDO52_11135	COG1981	membrane
LDO52_11145	COG1113	amino acid transport
LDO52_11150	COG0251	oxidation-reduction process
LDO52_11170	COG1652	LysM domain
LDO52_11175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LDO52_11180	COG1028	Short-chain dehydrogenase reductase Sdr
LDO52_11185	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LDO52_11195	COG1399	metal-binding, possibly nucleic acid-binding protein
LDO52_11200	COG3101	peptidyl-lysine hydroxylation
LDO52_11205	COG0009	L-threonylcarbamoyladenylate synthase
LDO52_11215	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LDO52_11220	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LDO52_11235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO52_11245	COG0339	signal peptide processing
LDO52_11295	COG2193	ferroxidase activity
LDO52_11300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDO52_11305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LDO52_11315	COG1196	nuclear chromosome segregation
LDO52_11325	COG0730	response to heat
LDO52_11350	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LDO52_11380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LDO52_11390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LDO52_11400	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LDO52_11415	COG1968	undecaprenyl-diphosphatase activity
LDO52_11420	COG1214	PFAM Peptidase M22, glycoprotease
LDO52_11430	COG0494	nUDIX hydrolase
LDO52_11465	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LDO52_11470	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LDO52_11520	COG2853	Lipoprotein
LDO52_11535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LDO52_11540	COG1764	response to oxidative stress
LDO52_11585	COG0037	tRNA processing
LDO52_11595	COG0248	Ppx GppA phosphatase
LDO52_11620	COG0072	phenylalanine-tRNA ligase activity
LDO52_11625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LDO52_11645	COG1238	metal cluster binding
LDO52_11655	COG0625	glutathione transferase activity
LDO52_11670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LDO52_11690	COG0318	PFAM AMP-dependent synthetase and ligase
LDO52_11705	COG4206	TonB-dependent receptor
LDO52_11710	COG2096	Adenosyltransferase
LDO52_11735	COG0745	RESPONSE REGULATOR receiver
LDO52_11740	COG2205	protein histidine kinase activity
LDO52_11750	COG1960	acyl-CoA dehydrogenase activity
LDO52_11755	COG1960	acyl-CoA dehydrogenase activity
LDO52_11795	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LDO52_11840	COG0438	transferase activity, transferring glycosyl groups
LDO52_11840	COG4641	Protein conserved in bacteria
LDO52_11865	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LDO52_11870	COG2205	protein histidine kinase activity
LDO52_11885	COG1660	Displays ATPase and GTPase activities
LDO52_11900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LDO52_11905	COG0617	tRNA 3'-terminal CCA addition
LDO52_11910	COG1596	polysaccharide export
LDO52_11910	COG1555	photosystem II stabilization
LDO52_11915	COG3956	TIGRFAM MazG family protein
LDO52_11920	COG0300	oxidoreductase activity
LDO52_11960	COG0124	histidyl-tRNA synthetase
LDO52_12010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LDO52_12015	COG0440	acetolactate synthase activity
LDO52_12020	COG0028	Belongs to the TPP enzyme family
LDO52_12050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDO52_12055	COG0577	efflux transmembrane transporter activity
LDO52_12055	COG1136	(ABC) transporter
LDO52_12060	COG1538	Outer membrane efflux protein
LDO52_12070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LDO52_12080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LDO52_12085	COG1162	GTPase activity
LDO52_12110	COG0084	hydrolase, TatD family'
LDO52_12115	COG0726	polysaccharide deacetylase
LDO52_12125	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LDO52_12135	COG0793	Belongs to the peptidase S41A family
LDO52_12160	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LDO52_12165	COG0280	phosphate acetyltransferase
LDO52_12165	COG0857	belongs to the CobB CobQ family
LDO52_12180	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LDO52_12180	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LDO52_12195	COG0740	serine-type endopeptidase activity
LDO52_12210	COG4771	TonB-dependent receptor
LDO52_12230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LDO52_12240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDO52_12240	COG2813	Specifically methylates the guanine in position
LDO52_12305	COG3040	lipid binding
LDO52_12310	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LDO52_12315	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LDO52_12350	COG0788	formyltetrahydrofolate deformylase activity
LDO52_12375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LDO52_12375	COG4651	solute:proton antiporter activity
LDO52_12395	COG0210	DNA helicase
LDO52_12400	COG1929	Belongs to the glycerate kinase type-1 family
LDO52_12425	COG2900	Belongs to the SlyX family
LDO52_12430	COG0488	(ABC) transporter
LDO52_12435	COG1560	Kdo2-lipid A biosynthetic process
LDO52_12495	COG0473	3-isopropylmalate dehydrogenase activity
LDO52_12510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LDO52_12520	COG0583	DNA-binding transcription factor activity
LDO52_12540	COG0494	nUDIX hydrolase
LDO52_12560	COG0753	catalase activity
LDO52_12585	COG0446	pyridine nucleotide-disulphide oxidoreductase
LDO52_12590	COG3384	dioxygenase
LDO52_12610	COG4638	Rieske (2fe-2S)
LDO52_12615	COG0583	DNA-binding transcription factor activity
LDO52_12635	COG4569	acetaldehyde dehydrogenase (acetylating) activity
LDO52_12640	COG3971	2-oxopent-4-enoate hydratase activity
LDO52_12645	COG0546	phosphoglycolate phosphatase activity
LDO52_12655	COG1530	ribonuclease E activity
LDO52_12660	COG0318	PFAM AMP-dependent synthetase and ligase
LDO52_12685	COG1983	PspC domain protein
LDO52_12695	COG0471	metal ion transport
LDO52_12715	COG0751	glycine-tRNA ligase activity
LDO52_12735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LDO52_12760	COG0493	'glutamate synthase
LDO52_12770	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LDO52_12780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDO52_12795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LDO52_12805	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LDO52_12805	COG0644	oxidoreductase
LDO52_12810	COG0425	Belongs to the sulfur carrier protein TusA family
LDO52_12815	COG4535	Mg2 and Co2 transporter CorC
LDO52_12820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LDO52_12830	COG2165	general secretion pathway protein
LDO52_12840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LDO52_12845	COG0475	glutathione-regulated potassium exporter activity
LDO52_12845	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LDO52_12850	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LDO52_12860	COG0789	Transcriptional regulator
LDO52_12865	COG2841	Protein conserved in bacteria
LDO52_12870	COG1185	polyribonucleotide nucleotidyltransferase activity
LDO52_12875	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LDO52_12880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LDO52_12885	COG1074	ATP-dependent DNA helicase activity
LDO52_12890	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LDO52_12920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LDO52_12955	COG0427	acetyl-CoA hydrolase
LDO52_12960	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LDO52_12990	COG0326	Molecular chaperone. Has ATPase activity
LDO52_13000	COG3047	cAMP biosynthetic process
LDO52_13005	COG2056	Na+-H+ antiporter family
LDO52_13025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LDO52_13030	COG0085	RNA polymerase activity
LDO52_13040	COG0222	ribosome binding
LDO52_13045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LDO52_13050	COG0081	regulation of translation
LDO52_13075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LDO52_13155	COG0181	hydroxymethylbilane synthase activity
LDO52_13165	COG3275	phosphorelay sensor kinase activity
LDO52_13180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LDO52_13205	COG1024	Enoyl-CoA hydratase
LDO52_13205	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO52_13270	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LDO52_13295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO52_13300	COG0531	amino acid
LDO52_13320	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LDO52_13355	COG3158	transport of potassium into the cell
LDO52_13380	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
LDO52_13390	COG1335	isochorismatase
LDO52_13395	COG0583	DNA-binding transcription factor activity
LDO52_13405	COG0629	single-stranded DNA binding
LDO52_13410	COG2814	Major facilitator Superfamily
LDO52_13420	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LDO52_13420	COG0351	phosphomethylpyrimidine kinase
LDO52_13420	COG0352	thiamine-phosphate diphosphorylase activity
LDO52_13440	COG3706	GGDEF domain
LDO52_13450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LDO52_13460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDO52_13465	COG3162	membrane
LDO52_13470	COG0784	Response regulator, receiver
LDO52_13470	COG2205	protein histidine kinase activity
LDO52_13485	COG0431	NADPH-dependent FMN reductase
LDO52_13490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO52_13495	COG0307	riboflavin synthase, alpha
LDO52_13500	COG0415	Belongs to the DNA photolyase family
LDO52_13510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO52_13515	COG3152	Membrane
LDO52_13520	COG0668	transmembrane transport
LDO52_13525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LDO52_13530	COG1519	Transferase
LDO52_13535	COG1902	pentaerythritol trinitrate reductase activity
LDO52_13560	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LDO52_13585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LDO52_13585	COG0426	domain, Protein
LDO52_13590	COG2119	membrane
LDO52_13595	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO52_13620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LDO52_13630	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LDO52_13640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LDO52_13665	COG0189	ligase activity
LDO52_13680	COG2132	Multicopper oxidase
LDO52_13695	COG1278	Cold shock
LDO52_13700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LDO52_13705	COG0708	Exodeoxyribonuclease III
LDO52_13710	COG1393	Belongs to the ArsC family
LDO52_13760	COG1247	-acetyltransferase
LDO52_13790	COG3150	esterase
LDO52_13800	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LDO52_13805	COG2918	glutathione biosynthetic process
LDO52_13820	COG2733	membrane
LDO52_13860	COG0753	catalase activity
LDO52_13890	COG0385	Bile acid
LDO52_13895	COG1335	isochorismatase
LDO52_13905	COG2814	Major facilitator Superfamily
LDO52_13910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDO52_13920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LDO52_13925	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LDO52_13930	COG3300	MHYT domain
LDO52_13930	COG5001	Diguanylate cyclase
LDO52_13935	COG2983	Belongs to the UPF0260 family
LDO52_13940	COG5487	UPF0391 membrane protein
LDO52_13945	COG0728	peptidoglycan biosynthetic process
LDO52_13950	COG3023	N-Acetylmuramoyl-L-alanine amidase
LDO52_13965	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LDO52_13970	COG1309	transcriptional regulator
LDO52_13990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LDO52_13995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LDO52_14000	COG0546	phosphoglycolate phosphatase activity
LDO52_14005	COG1028	Short-chain dehydrogenase reductase Sdr
LDO52_14035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LDO52_14035	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LDO52_14040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LDO52_14045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LDO52_14050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LDO52_14055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDO52_14060	COG1116	anion transmembrane transporter activity
LDO52_14065	COG1309	transcriptional regulator
LDO52_14075	COG0196	riboflavin kinase activity
LDO52_14080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LDO52_14085	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LDO52_14090	COG1047	Peptidyl-prolyl cis-trans
LDO52_14100	COG2133	pyrroloquinoline quinone binding
LDO52_14135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LDO52_14140	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LDO52_14145	COG2951	lytic endotransglycosylase activity
LDO52_14150	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LDO52_14165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LDO52_14180	COG2388	GCN5-related N-acetyl-transferase
LDO52_14185	COG2814	Major facilitator Superfamily
LDO52_14190	COG0861	Integral membrane protein TerC family
LDO52_14195	COG0402	S-adenosylhomocysteine deaminase activity
LDO52_14225	COG0706	membrane insertase activity
LDO52_14230	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LDO52_14235	COG0594	ribonuclease P activity
LDO52_14285	COG2801	Transposase and inactivated derivatives
LDO52_14320	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
LDO52_14330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDO52_14340	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LDO52_14345	COG3657	addiction module killer protein
LDO52_14350	COG1028	Short-chain dehydrogenase reductase Sdr
LDO52_14405	COG0582	viral genome integration into host DNA
LDO52_14410	COG3321	synthase
LDO52_14410	COG1028	Short-chain dehydrogenase reductase Sdr
LDO52_14410	COG0604	alcohol dehydrogenase
LDO52_14425	COG0753	catalase activity
LDO52_14435	COG0133	tryptophan synthase activity
LDO52_14445	COG0675	Transposase, IS605 OrfB family
LDO52_14485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LDO52_14500	COG0642	Histidine kinase
LDO52_14505	COG0745	RESPONSE REGULATOR receiver
LDO52_14530	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LDO52_14595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LDO52_14635	COG1063	alcohol dehydrogenase
LDO52_14650	COG4716	Myosin-crossreactive antigen
LDO52_14670	COG1846	Transcriptional regulator
LDO52_14675	COG1764	response to oxidative stress
LDO52_14710	COG4372	Transposase
LDO52_14725	COG1380	Effector of murein hydrolase LrgA
LDO52_14730	COG0583	DNA-binding transcription factor activity
LDO52_14735	COG0730	response to heat
LDO52_14740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LDO52_14745	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LDO52_14760	COG2186	Transcriptional regulator
LDO52_14795	COG4106	trans-aconitate 2-methyltransferase activity
LDO52_14805	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LDO52_14805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LDO52_14810	COG2267	carboxylic ester hydrolase activity
LDO52_14810	COG2226	methyltransferase
LDO52_14815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LDO52_14860	COG1454	alcohol dehydrogenase
LDO52_14885	COG4774	siderophore transport
LDO52_14910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LDO52_14935	COG0640	Transcriptional regulator
LDO52_14950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDO52_14965	COG0642	Histidine kinase
LDO52_14980	COG1192	Involved in chromosome partitioning
LDO52_14985	COG1475	DNA binding
LDO52_15005	COG3586	endonuclease activity
LDO52_15030	COG0640	Transcriptional regulator
LDO52_15040	COG0798	PFAM Bile acid sodium symporter
LDO52_15045	COG0431	NADPH-dependent FMN reductase
LDO52_15050	COG2072	flavoprotein involved in K transport
LDO52_15060	COG4628	conserved protein (DUF2132)
LDO52_15080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LDO52_15085	COG3550	peptidyl-serine autophosphorylation
LDO52_15175	COG1373	ATPase (AAA superfamily
LDO52_15290	COG2963	transposase activity
LDO52_15315	COG2801	Transposase and inactivated derivatives
LDO52_15320	COG3657	addiction module killer protein
LDO52_15325	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LDO52_15345	COG0488	(ABC) transporter
LDO52_15350	COG3173	Aminoglycoside phosphotransferase
LDO52_15455	COG2184	nucleotidyltransferase activity
LDO52_15470	COG1475	DNA binding
LDO52_15475	COG1192	Involved in chromosome partitioning
LDO52_15520	COG2132	Multicopper oxidase
LDO52_15530	COG2801	Transposase and inactivated derivatives
LDO52_15535	COG3077	Addiction module antitoxin, RelB DinJ family
LDO52_15545	COG2801	Transposase and inactivated derivatives
LDO52_15565	COG4372	Transposase
LDO52_15585	COG2801	Transposase and inactivated derivatives
LDO52_15660	COG1192	Involved in chromosome partitioning
LDO52_15670	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LDO52_15720	COG1660	Displays ATPase and GTPase activities
LDO52_15780	COG1959	2 iron, 2 sulfur cluster binding
LDO52_15785	COG0720	synthase
LDO52_15810	COG4974	Belongs to the 'phage' integrase family
LDO52_15870	COG4974	Belongs to the 'phage' integrase family
LDO52_15915	COG1683	Conserved Protein
LDO52_15950	COG1230	cation diffusion facilitator family transporter
LDO52_15960	COG0789	Transcriptional regulator
LDO52_15965	COG0582	viral genome integration into host DNA
LDO52_15980	COG2369	cell adhesion
LDO52_16060	COG3077	Addiction module antitoxin, RelB DinJ family
LDO52_16185	COG0488	(ABC) transporter
LDO52_16190	COG3173	Aminoglycoside phosphotransferase