locus-tag	class	description
E3H47_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E3H47_00010	COG0592	DNA-directed DNA polymerase activity
E3H47_00020	COG0187	DNA topoisomerase II activity
E3H47_00025	COG1063	alcohol dehydrogenase
E3H47_00035	COG0488	(ABC) transporter
E3H47_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E3H47_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E3H47_00085	COG1047	Peptidyl-prolyl cis-trans
E3H47_00090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E3H47_00095	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E3H47_00100	COG0196	riboflavin kinase activity
E3H47_00120	COG1116	anion transmembrane transporter activity
E3H47_00125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3H47_00130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3H47_00135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E3H47_00140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E3H47_00145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E3H47_00145	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E3H47_00160	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_00165	COG0546	phosphoglycolate phosphatase activity
E3H47_00180	COG1309	transcriptional regulator
E3H47_00190	COG0543	2 iron, 2 sulfur cluster binding
E3H47_00200	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E3H47_00260	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E3H47_00305	COG0438	transferase activity, transferring glycosyl groups
E3H47_00310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3H47_00320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E3H47_00330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E3H47_00345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3H47_00350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3H47_00365	COG0271	Belongs to the BolA IbaG family
E3H47_00380	COG0586	Pfam SNARE associated Golgi protein
E3H47_00385	COG0519	Catalyzes the synthesis of GMP from XMP
E3H47_00385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3H47_00415	COG0281	malic enzyme
E3H47_00420	COG3501	Rhs element vgr protein
E3H47_00480	COG2837	iron assimilation
E3H47_00485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3H47_00490	COG1121	(ABC) transporter
E3H47_00550	COG1012	belongs to the aldehyde dehydrogenase family
E3H47_00565	COG0386	Belongs to the glutathione peroxidase family
E3H47_00580	COG0697	spore germination
E3H47_00590	COG0758	DNA mediated transformation
E3H47_00595	COG1652	LysM domain
E3H47_00640	COG2814	Major facilitator Superfamily
E3H47_00650	COG2814	Major facilitator Superfamily
E3H47_00670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3H47_00695	COG1253	flavin adenine dinucleotide binding
E3H47_00705	COG2860	membrane
E3H47_00710	COG0477	Major facilitator Superfamily
E3H47_00720	COG0318	PFAM AMP-dependent synthetase and ligase
E3H47_00735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E3H47_00750	COG0606	chelatase, subunit chli
E3H47_00760	COG0347	Belongs to the P(II) protein family
E3H47_00765	COG0004	ammonium transporteR
E3H47_00775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3H47_00775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3H47_00805	COG0795	lipopolysaccharide-transporting ATPase activity
E3H47_00810	COG0795	lipopolysaccharide-transporting ATPase activity
E3H47_00815	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E3H47_00820	COG0793	Belongs to the peptidase S41A family
E3H47_00835	COG2197	response regulator
E3H47_00845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E3H47_00860	COG4974	Belongs to the 'phage' integrase family
E3H47_00885	COG0772	Belongs to the SEDS family
E3H47_00895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3H47_00900	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3H47_00910	COG0494	nUDIX hydrolase
E3H47_00945	COG3275	phosphorelay sensor kinase activity
E3H47_00955	COG0181	hydroxymethylbilane synthase activity
E3H47_01000	COG1716	ATPase activity
E3H47_01005	COG0546	phosphoglycolate phosphatase activity
E3H47_01075	COG0085	RNA polymerase activity
E3H47_01080	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E3H47_01095	COG2056	Na+-H+ antiporter family
E3H47_01105	COG0326	Molecular chaperone. Has ATPase activity
E3H47_01125	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E3H47_01155	COG0322	excinuclease ABC activity
E3H47_01165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3H47_01170	COG1132	(ABC) transporter
E3H47_01200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E3H47_01210	COG0497	DNA recombination
E3H47_01220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3H47_01225	COG0697	spore germination
E3H47_01230	COG0237	dephospho-CoA kinase activity
E3H47_01275	COG0779	Required for maturation of 30S ribosomal subunits
E3H47_01280	COG0195	Participates in both transcription termination and antitermination
E3H47_01300	COG2212	antiporter activity
E3H47_01310	COG0651	ATP synthesis coupled electron transport
E3H47_01315	COG1006	Multisubunit Na H antiporter MnhC subunit
E3H47_01320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3H47_01320	COG2111	Na H antiporter
E3H47_01335	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E3H47_01340	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E3H47_01370	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E3H47_01375	COG1074	ATP-dependent DNA helicase activity
E3H47_01380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3H47_01390	COG1185	polyribonucleotide nucleotidyltransferase activity
E3H47_01395	COG0598	Magnesium transport protein CorA
E3H47_01405	COG0484	heat shock protein binding
E3H47_01415	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E3H47_01425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3H47_01445	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E3H47_01450	COG4535	Mg2 and Co2 transporter CorC
E3H47_01460	COG0425	Belongs to the sulfur carrier protein TusA family
E3H47_01470	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E3H47_01470	COG0644	oxidoreductase
E3H47_01480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E3H47_01495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3H47_01505	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E3H47_01515	COG0493	'glutamate synthase
E3H47_01515	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3H47_01530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E3H47_01540	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E3H47_01545	COG0534	Mate efflux family protein
E3H47_01555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3H47_01560	COG1280	lysine exporter protein (LysE YggA)
E3H47_01590	COG1530	ribonuclease E activity
E3H47_01605	COG0546	phosphoglycolate phosphatase activity
E3H47_01610	COG3971	2-oxopent-4-enoate hydratase activity
E3H47_01615	COG4569	acetaldehyde dehydrogenase (acetylating) activity
E3H47_01645	COG0583	DNA-binding transcription factor activity
E3H47_01650	COG4638	Rieske (2fe-2S)
E3H47_01665	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_01670	COG3384	dioxygenase
E3H47_01675	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3H47_01700	COG0753	catalase activity
E3H47_01710	COG1960	acyl-CoA dehydrogenase activity
E3H47_01725	COG0494	nUDIX hydrolase
E3H47_01735	COG0583	DNA-binding transcription factor activity
E3H47_01740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E3H47_01755	COG0473	3-isopropylmalate dehydrogenase activity
E3H47_01810	COG1560	Kdo2-lipid A biosynthetic process
E3H47_01855	COG1929	Belongs to the glycerate kinase type-1 family
E3H47_01860	COG0210	DNA helicase
E3H47_01865	COG0724	RNA recognition motif
E3H47_01880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3H47_01880	COG4651	solute:proton antiporter activity
E3H47_01885	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E3H47_01890	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E3H47_01905	COG0788	formyltetrahydrofolate deformylase activity
E3H47_01940	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E3H47_01960	COG0500	methyltransferase
E3H47_02025	COG2813	Specifically methylates the guanine in position
E3H47_02025	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3H47_02030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3H47_02035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E3H47_02045	COG4774	siderophore transport
E3H47_02055	COG0740	serine-type endopeptidase activity
E3H47_02070	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E3H47_02070	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E3H47_02080	COG0857	belongs to the CobB CobQ family
E3H47_02080	COG0280	phosphate acetyltransferase
E3H47_02085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E3H47_02100	COG2267	carboxylic ester hydrolase activity
E3H47_02115	COG0793	Belongs to the peptidase S41A family
E3H47_02150	COG1426	Protein conserved in bacteria
E3H47_02160	COG0124	histidyl-tRNA synthetase
E3H47_02170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3H47_02195	COG1862	Preprotein translocase
E3H47_02205	COG1704	LemA family
E3H47_02230	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E3H47_02245	COG0726	polysaccharide deacetylase
E3H47_02265	COG1091	dTDP-4-dehydrorhamnose reductase activity
E3H47_02280	COG1215	transferase activity, transferring glycosyl groups
E3H47_02335	COG1538	Outer membrane efflux protein
E3H47_02340	COG1136	(ABC) transporter
E3H47_02340	COG0577	efflux transmembrane transporter activity
E3H47_02345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3H47_02370	COG0028	Belongs to the TPP enzyme family
E3H47_02375	COG0440	acetolactate synthase activity
E3H47_02390	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E3H47_02405	COG0084	hydrolase, TatD family'
E3H47_02415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3H47_02420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3H47_02430	COG2814	Major facilitator Superfamily
E3H47_02435	COG0697	spore germination
E3H47_02440	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E3H47_02445	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E3H47_02450	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E3H47_02460	COG3622	Belongs to the hyi family
E3H47_02465	COG2084	Dehydrogenase
E3H47_02470	COG1024	Enoyl-CoA hydratase
E3H47_02475	COG2205	protein histidine kinase activity
E3H47_02475	COG5002	protein histidine kinase activity
E3H47_02475	COG0784	Response regulator, receiver
E3H47_02495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3H47_02505	COG3956	TIGRFAM MazG family protein
E3H47_02510	COG1555	photosystem II stabilization
E3H47_02515	COG0617	tRNA 3'-terminal CCA addition
E3H47_02520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3H47_02530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E3H47_02535	COG1660	Displays ATPase and GTPase activities
E3H47_02540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3H47_02545	COG3028	Belongs to the UPF0307 family
E3H47_02560	COG0318	PFAM AMP-dependent synthetase and ligase
E3H47_02580	COG0625	glutathione transferase activity
E3H47_02585	COG1238	metal cluster binding
E3H47_02605	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E3H47_02625	COG0072	phenylalanine-tRNA ligase activity
E3H47_02650	COG0248	Ppx GppA phosphatase
E3H47_02660	COG0037	tRNA processing
E3H47_02700	COG1764	response to oxidative stress
E3H47_02705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3H47_02755	COG2969	positive regulation of protein catabolic process
E3H47_02760	COG0625	glutathione transferase activity
E3H47_02765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E3H47_02780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E3H47_02785	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E3H47_02790	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E3H47_02800	COG1346	cytolysis
E3H47_02810	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3H47_02820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3H47_02825	COG1408	metallophosphoesterase
E3H47_02830	COG0477	Major facilitator Superfamily
E3H47_02835	COG1272	protein, Hemolysin III
E3H47_02845	COG4667	esterase of the alpha-beta hydrolase superfamily
E3H47_02855	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3H47_02855	COG1024	Enoyl-CoA hydratase
E3H47_02860	COG0183	Belongs to the thiolase family
E3H47_02865	COG2207	Transcriptional regulator
E3H47_02875	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3H47_02885	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E3H47_02895	COG1289	transmembrane transporter activity
E3H47_02900	COG2814	Major facilitator Superfamily
E3H47_02915	COG0786	glutamate:sodium symporter activity
E3H47_02920	COG1115	amino acid carrier protein
E3H47_02925	COG2059	Chromate
E3H47_02930	COG1752	Esterase of the alpha-beta hydrolase superfamily
E3H47_02955	COG1024	Enoyl-CoA hydratase
E3H47_02960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E3H47_02965	COG1960	acyl-CoA dehydrogenase activity
E3H47_02970	COG1309	transcriptional regulator
E3H47_02975	COG0318	PFAM AMP-dependent synthetase and ligase
E3H47_02980	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E3H47_03005	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3H47_03015	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3H47_03020	COG1077	Cell shape determining protein MreB Mrl
E3H47_03025	COG1792	Involved in formation and maintenance of cell shape
E3H47_03030	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E3H47_03035	COG0424	maF-like protein
E3H47_03040	COG1530	ribonuclease E activity
E3H47_03045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3H47_03055	COG0560	Phosphoserine phosphatase
E3H47_03075	COG0642	Histidine kinase
E3H47_03080	COG0745	RESPONSE REGULATOR receiver
E3H47_03085	COG2194	sulfuric ester hydrolase activity
E3H47_03095	COG1113	amino acid transport
E3H47_03100	COG2828	Protein conserved in bacteria
E3H47_03105	COG2824	Alkylphosphonate utilization operon protein PhnA
E3H47_03110	COG0142	geranyltranstransferase activity
E3H47_03125	COG0210	DNA helicase
E3H47_03140	COG1484	DNA-dependent DNA replication
E3H47_03190	COG1752	Esterase of the alpha-beta hydrolase superfamily
E3H47_03215	COG1309	transcriptional regulator
E3H47_03235	COG0004	ammonium transporteR
E3H47_03240	COG1126	abc transporter atp-binding protein
E3H47_03245	COG0765	amino acid transport
E3H47_03250	COG0765	amino acid transport
E3H47_03280	COG0525	valine-tRNA ligase activity
E3H47_03290	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_03300	COG0393	Putative heavy-metal-binding
E3H47_03305	COG1538	Outer membrane efflux protein
E3H47_03315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3H47_03320	COG0671	phosphoesterase, PA-phosphatase related
E3H47_03335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E3H47_03340	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E3H47_03345	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E3H47_03370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3H47_03380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E3H47_03380	COG1648	precorrin-2 dehydrogenase activity
E3H47_03385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E3H47_03390	COG0531	amino acid
E3H47_03405	COG0321	lipoyl(octanoyl) transferase activity
E3H47_03430	COG0586	Pfam SNARE associated Golgi protein
E3H47_03450	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E3H47_03470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E3H47_03500	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E3H47_03515	COG0358	DNA primase activity
E3H47_03525	COG0564	pseudouridine synthase activity
E3H47_03545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3H47_03575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3H47_03575	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E3H47_03590	COG2009	succinate dehydrogenase
E3H47_03595	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E3H47_03600	COG1053	succinate dehydrogenase
E3H47_03620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3H47_03630	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3H47_03640	COG2354	Protein conserved in bacteria
E3H47_03645	COG2321	neutral zinc metallopeptidase
E3H47_03670	COG0110	maltose O-acetyltransferase activity
E3H47_03680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3H47_03685	COG0505	Belongs to the CarA family
E3H47_03710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3H47_03715	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E3H47_03750	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E3H47_03770	COG0459	protein refolding
E3H47_03785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3H47_03790	COG2239	Acts as a magnesium transporter
E3H47_03800	COG0501	Belongs to the peptidase M48B family
E3H47_03805	COG1196	nuclear chromosome segregation
E3H47_03805	COG0741	lytic transglycosylase activity
E3H47_03805	COG0739	heme binding
E3H47_03810	COG0037	tRNA processing
E3H47_03820	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E3H47_03825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3H47_03855	COG1215	transferase activity, transferring glycosyl groups
E3H47_03880	COG0439	Biotin carboxylase
E3H47_03895	COG0864	Transcriptional regulator
E3H47_03905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3H47_03930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3H47_03935	COG2814	Major facilitator Superfamily
E3H47_03950	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3H47_03960	COG0154	amidase activity
E3H47_03990	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_04000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3H47_04115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E3H47_04120	COG3739	integral membrane protein
E3H47_04135	COG3706	GGDEF domain
E3H47_04155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3H47_04160	COG0512	Glutamine amidotransferase of anthranilate synthase
E3H47_04180	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E3H47_04215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E3H47_04220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E3H47_04225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3H47_04240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E3H47_04250	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E3H47_04255	COG0415	Belongs to the DNA photolyase family
E3H47_04265	COG1252	NADH dehydrogenase
E3H47_04270	COG1686	Belongs to the peptidase S11 family
E3H47_04315	COG0612	Peptidase, M16
E3H47_04335	COG3025	triphosphatase activity
E3H47_04345	COG0352	thiamine-phosphate diphosphorylase activity
E3H47_04400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3H47_04405	COG0076	glutamate decarboxylase activity
E3H47_04410	COG1522	sequence-specific DNA binding
E3H47_04415	COG3961	Belongs to the TPP enzyme family
E3H47_04420	COG1113	amino acid transport
E3H47_04430	COG0573	inorganic phosphate transmembrane transporter activity
E3H47_04440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3H47_04450	COG0616	signal peptide processing
E3H47_04470	COG2915	High frequency lysogenization protein hflD homolog
E3H47_04485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E3H47_04490	COG1686	Belongs to the peptidase S11 family
E3H47_04515	COG0583	DNA-binding transcription factor activity
E3H47_04520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3H47_04525	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E3H47_04530	COG1067	ATP-dependent peptidase activity
E3H47_04575	COG1966	Carbon starvation protein
E3H47_04580	COG2879	small protein
E3H47_04585	COG0714	Associated with various cellular activities
E3H47_04680	COG1396	sequence-specific DNA binding
E3H47_04885	COG3179	chitinase
E3H47_04955	COG3179	chitinase
E3H47_05000	COG0659	secondary active sulfate transmembrane transporter activity
E3H47_05010	COG2252	PERMEase
E3H47_05015	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E3H47_05025	COG1215	transferase activity, transferring glycosyl groups
E3H47_05035	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E3H47_05045	COG0527	aspartate kinase activity
E3H47_05055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E3H47_05070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E3H47_05085	COG0667	Aldo Keto reductase
E3H47_05095	COG1765	OsmC-like protein
E3H47_05115	COG0540	Belongs to the ATCase OTCase family
E3H47_05125	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E3H47_05125	COG2885	chlorophyll binding
E3H47_05140	COG0596	Alpha beta hydrolase
E3H47_05140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3H47_05140	COG2226	methyltransferase
E3H47_05145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E3H47_05180	COG1278	Cold shock
E3H47_05185	COG0513	Belongs to the DEAD box helicase family
E3H47_05195	COG0778	Nitroreductase
E3H47_05225	COG1286	toxin biosynthetic process
E3H47_05250	COG4783	chaperone-mediated protein folding
E3H47_05255	COG1610	YqeY-like protein
E3H47_05260	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E3H47_05285	COG0515	serine threonine protein kinase
E3H47_05285	COG2815	serine threonine protein kinase
E3H47_05365	COG2308	Evidence 4 Homologs of previously reported genes of
E3H47_05385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3H47_05390	COG0305	Participates in initiation and elongation during chromosome replication
E3H47_05400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E3H47_05405	COG0360	Binds together with S18 to 16S ribosomal RNA
E3H47_05415	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E3H47_05420	COG1845	cytochrome c oxidase, subunit III
E3H47_05425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3H47_05430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E3H47_05455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E3H47_05475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3H47_05490	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E3H47_05495	COG2890	protein-(glutamine-N5) methyltransferase activity
E3H47_05510	COG1960	acyl-CoA dehydrogenase activity
E3H47_05515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3H47_05535	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E3H47_05555	COG0729	surface antigen
E3H47_05560	COG2911	Protein conserved in bacteria
E3H47_05605	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3H47_05610	COG4605	iron ion homeostasis
E3H47_05615	COG4604	ABC transporter, ATP-binding protein
E3H47_05620	COG4607	ABC-type enterochelin transport system periplasmic component
E3H47_05625	COG2814	Major facilitator Superfamily
E3H47_05630	COG0786	glutamate:sodium symporter activity
E3H47_05635	COG0583	DNA-binding transcription factor activity
E3H47_05640	COG2707	UPF0756 membrane protein
E3H47_05655	COG0564	pseudouridine synthase activity
E3H47_05660	COG0802	atpase or kinase
E3H47_05665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E3H47_05675	COG1923	regulation of RNA biosynthetic process
E3H47_05680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3H47_05695	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E3H47_05705	COG1192	Involved in chromosome partitioning
E3H47_05710	COG1475	DNA binding
E3H47_05715	COG0811	peptide transport
E3H47_05725	COG1132	(ABC) transporter
E3H47_05730	COG1663	tetraacyldisaccharide 4'-kinase activity
E3H47_05750	COG0084	hydrolase, TatD family'
E3H47_05760	COG2165	general secretion pathway protein
E3H47_05775	COG3156	type II secretion system protein K
E3H47_05795	COG0590	tRNA wobble adenosine to inosine editing
E3H47_05815	COG0776	regulation of translation
E3H47_05835	COG1396	sequence-specific DNA binding
E3H47_05845	COG2431	L-lysine efflux transmembrane transporter activity
E3H47_05860	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E3H47_05870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3H47_05885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E3H47_05890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E3H47_05895	COG0022	dehydrogenase e1 component
E3H47_05900	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3H47_05905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3H47_05910	COG1063	alcohol dehydrogenase
E3H47_05945	COG1114	Component of the transport system for branched-chain amino acids
E3H47_05950	COG0024	Methionine aminopeptidase
E3H47_05955	COG0583	DNA-binding transcription factor activity
E3H47_05965	COG0583	DNA-binding transcription factor activity
E3H47_05970	COG1960	acyl-CoA dehydrogenase activity
E3H47_05985	COG1585	Membrane protein implicated in regulation of membrane protease activity
E3H47_05995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3H47_06010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3H47_06015	COG0569	domain protein
E3H47_06020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3H47_06025	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E3H47_06035	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E3H47_06045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E3H47_06050	COG0542	response to heat
E3H47_06080	COG0372	Belongs to the citrate synthase family
E3H47_06090	COG2204	response regulator
E3H47_06095	COG3852	Histidine kinase
E3H47_06110	COG0233	cytoplasmic translational termination
E3H47_06115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3H47_06120	COG0575	Belongs to the CDS family
E3H47_06135	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3H47_06155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3H47_06170	COG2137	regulation of response to DNA damage stimulus
E3H47_06175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E3H47_06180	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E3H47_06185	COG1011	Hydrolase
E3H47_06200	COG0268	Binds directly to 16S ribosomal RNA
E3H47_06205	COG0702	epimerase
E3H47_06210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E3H47_06225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E3H47_06255	COG0316	Belongs to the HesB IscA family
E3H47_06260	COG0822	iron-sulfur transferase activity
E3H47_06285	COG0776	regulation of translation
E3H47_06290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3H47_06300	COG1960	acyl-CoA dehydrogenase activity
E3H47_06305	COG1960	acyl-CoA dehydrogenase activity
E3H47_06330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E3H47_06335	COG1546	Belongs to the CinA family
E3H47_06335	COG1058	Belongs to the CinA family
E3H47_06365	COG1278	Cold shock
E3H47_06370	COG2323	membrane
E3H47_06375	COG0671	phosphoesterase, PA-phosphatase related
E3H47_06385	COG2819	hydrolase of the alpha beta superfamily
E3H47_06395	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_06430	COG3706	GGDEF domain
E3H47_06430	COG0745	RESPONSE REGULATOR receiver
E3H47_06460	COG0439	Biotin carboxylase
E3H47_06470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E3H47_06495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3H47_06555	COG1271	oxidase subunit
E3H47_06560	COG1294	oxidase, subunit
E3H47_06575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3H47_06620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3H47_06625	COG1027	Aspartate ammonia-lyase
E3H47_06635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3H47_06645	COG1448	Aminotransferase
E3H47_06650	COG1113	amino acid transport
E3H47_06665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3H47_06670	COG2814	Major facilitator Superfamily
E3H47_06675	COG0509	glycine decarboxylation via glycine cleavage system
E3H47_06690	COG1132	(ABC) transporter
E3H47_06695	COG2199	diguanylate cyclase activity
E3H47_06695	COG2203	Gaf domain
E3H47_06710	COG3706	GGDEF domain
E3H47_06715	COG2801	Transposase and inactivated derivatives
E3H47_06730	COG0668	transmembrane transport
E3H47_06735	COG3122	Protein conserved in bacteria
E3H47_06755	COG0640	Transcriptional regulator
E3H47_06760	COG0783	Belongs to the Dps family
E3H47_06785	COG0235	Class ii aldolase
E3H47_06795	COG1024	Enoyl-CoA hydratase
E3H47_06815	COG3781	membrane
E3H47_06825	COG2985	domain, Protein
E3H47_06860	COG0583	DNA-binding transcription factor activity
E3H47_06905	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E3H47_06910	COG0210	DNA helicase
E3H47_06945	COG0477	Major facilitator Superfamily
E3H47_06950	COG1024	Enoyl-CoA hydratase
E3H47_06955	COG1024	Enoyl-CoA hydratase
E3H47_06960	COG1960	acyl-CoA dehydrogenase activity
E3H47_06965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3H47_06980	COG0583	DNA-binding transcription factor activity
E3H47_06990	COG3327	negative regulation of DNA-templated transcription, initiation
E3H47_06995	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E3H47_07000	COG1024	Enoyl-CoA hydratase
E3H47_07005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3H47_07010	COG2151	metal-sulfur cluster biosynthetic enzyme
E3H47_07015	COG3396	Phenylacetate-CoA oxygenase
E3H47_07020	COG3460	Phenylacetate-CoA oxygenase
E3H47_07025	COG3396	Phenylacetate-CoA oxygenase
E3H47_07030	COG1012	belongs to the aldehyde dehydrogenase family
E3H47_07030	COG2030	dehydratase
E3H47_07040	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E3H47_07045	COG4149	molybdate abc transporter
E3H47_07050	COG0725	ABC transporter, periplasmic molybdate-binding protein
E3H47_07055	COG0303	'Molybdopterin
E3H47_07060	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3H47_07060	COG0315	cyclic pyranopterin monophosphate synthase activity
E3H47_07065	COG0314	molybdopterin synthase activity
E3H47_07075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E3H47_07085	COG0243	molybdopterin cofactor binding
E3H47_07095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3H47_07100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3H47_07105	COG2223	nitrite transmembrane transporter activity
E3H47_07135	COG1570	exodeoxyribonuclease VII activity
E3H47_07160	COG2814	Major facilitator Superfamily
E3H47_07170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E3H47_07180	COG2814	Major facilitator Superfamily
E3H47_07185	COG1960	acyl-CoA dehydrogenase activity
E3H47_07190	COG0183	Belongs to the thiolase family
E3H47_07200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E3H47_07205	COG1960	acyl-CoA dehydrogenase activity
E3H47_07210	COG2814	Major facilitator Superfamily
E3H47_07215	COG2814	Major facilitator Superfamily
E3H47_07225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E3H47_07230	COG1960	acyl-CoA dehydrogenase activity
E3H47_07235	COG2814	Major facilitator Superfamily
E3H47_07240	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E3H47_07240	COG0644	oxidoreductase
E3H47_07265	COG0583	DNA-binding transcription factor activity
E3H47_07270	COG1380	Effector of murein hydrolase LrgA
E3H47_07275	COG1346	cytolysis
E3H47_07285	COG0406	alpha-ribazole phosphatase activity
E3H47_07290	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E3H47_07335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3H47_07380	COG1294	oxidase, subunit
E3H47_07385	COG4890	Cyd operon protein YbgT
E3H47_07405	COG0552	protein localization to endoplasmic reticulum
E3H47_07410	COG0612	Peptidase, M16
E3H47_07440	COG0516	GMP reductase activity
E3H47_07440	COG0517	IMP dehydrogenase activity
E3H47_07445	COG0133	tryptophan synthase activity
E3H47_07475	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E3H47_07500	COG0798	PFAM Bile acid sodium symporter
E3H47_07505	COG0640	Transcriptional regulator
E3H47_07550	COG1278	Cold shock
E3H47_07555	COG1560	Kdo2-lipid A biosynthetic process
E3H47_07570	COG0537	adenosine 5'-monophosphoramidase activity
E3H47_07595	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3H47_07615	COG0730	response to heat
E3H47_07620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3H47_07650	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E3H47_07655	COG0148	phosphopyruvate hydratase activity
E3H47_07690	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3H47_07690	COG1902	pentaerythritol trinitrate reductase activity
E3H47_07705	COG0583	DNA-binding transcription factor activity
E3H47_07710	COG4948	Mandelate Racemase Muconate Lactonizing
E3H47_07715	COG4829	muconolactone delta-isomerase
E3H47_07725	COG4638	Rieske (2fe-2S)
E3H47_07730	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E3H47_07735	COG0543	2 iron, 2 sulfur cluster binding
E3H47_07735	COG0633	Ferredoxin
E3H47_07740	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_07750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E3H47_07755	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E3H47_07760	COG0183	Belongs to the thiolase family
E3H47_07765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3H47_07780	COG0477	Major facilitator Superfamily
E3H47_07785	COG0596	Alpha beta hydrolase
E3H47_07795	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E3H47_07815	COG2351	hydroxyisourate hydrolase activity
E3H47_07820	COG4772	TonB-dependent receptor
E3H47_07835	COG2084	Dehydrogenase
E3H47_07840	COG2233	PERMEase
E3H47_07845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3H47_07850	COG0251	oxidation-reduction process
E3H47_07855	COG1335	isochorismatase
E3H47_07860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3H47_07870	COG0596	Alpha beta hydrolase
E3H47_07885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3H47_07895	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3H47_07905	COG0697	spore germination
E3H47_07930	COG0424	maF-like protein
E3H47_07935	COG2850	peptidyl-arginine hydroxylation
E3H47_07940	COG0069	glutamate synthase activity
E3H47_07965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3H47_07970	COG1454	alcohol dehydrogenase
E3H47_07975	COG0824	Thioesterase
E3H47_07980	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3H47_08005	COG0183	Belongs to the thiolase family
E3H47_08015	COG0583	DNA-binding transcription factor activity
E3H47_08020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3H47_08030	COG3135	benzoate transporter
E3H47_08035	COG2076	Multidrug Resistance protein
E3H47_08050	COG0589	response to stress
E3H47_08055	COG0308	aminopeptidase N
E3H47_08075	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3H47_08080	COG1454	alcohol dehydrogenase
E3H47_08100	COG0531	amino acid
E3H47_08105	COG4303	Ethanolamine ammonia lyase large subunit
E3H47_08110	COG4302	ethanolamine ammonia-lyase activity
E3H47_08115	COG0519	Catalyzes the synthesis of GMP from XMP
E3H47_08115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3H47_08120	COG2353	YceI-like domain
E3H47_08130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E3H47_08165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E3H47_08165	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E3H47_08230	COG1464	Belongs to the NlpA lipoprotein family
E3H47_08235	COG1464	Belongs to the NlpA lipoprotein family
E3H47_08240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E3H47_08245	COG2011	ABC-type metal ion transport system permease component
E3H47_08250	COG0012	GTP binding
E3H47_08265	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E3H47_08280	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E3H47_08285	COG0436	Aminotransferase
E3H47_08290	COG0386	Belongs to the glutathione peroxidase family
E3H47_08295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3H47_08300	COG0436	Aminotransferase
E3H47_08305	COG1464	Belongs to the NlpA lipoprotein family
E3H47_08310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E3H47_08315	COG2011	ABC-type metal ion transport system permease component
E3H47_08350	COG0242	peptide deformylase activity
E3H47_08365	COG0028	Belongs to the TPP enzyme family
E3H47_08380	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_08385	COG2267	carboxylic ester hydrolase activity
E3H47_08395	COG2271	Major facilitator Superfamily
E3H47_08400	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3H47_08410	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_08430	COG1414	Transcriptional regulator
E3H47_08435	COG4638	Rieske (2fe-2S)
E3H47_08440	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E3H47_08445	COG0543	2 iron, 2 sulfur cluster binding
E3H47_08445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3H47_08455	COG2271	Major facilitator Superfamily
E3H47_08460	COG2207	Transcriptional regulator
E3H47_08485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E3H47_08505	COG3052	prosthetic group binding
E3H47_08510	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E3H47_08525	COG0583	DNA-binding transcription factor activity
E3H47_08595	COG3706	GGDEF domain
E3H47_08600	COG1280	lysine exporter protein (LysE YggA)
E3H47_08605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3H47_08610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E3H47_08645	COG0583	DNA-binding transcription factor activity
E3H47_08655	COG2814	Major facilitator Superfamily
E3H47_08665	COG0318	PFAM AMP-dependent synthetase and ligase
E3H47_08675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E3H47_08680	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_08685	COG1846	Transcriptional regulator
E3H47_08725	COG4264	IucA IucC family
E3H47_08730	COG4264	IucA IucC family
E3H47_08745	COG4264	IucA IucC family
E3H47_08750	COG0789	Transcriptional regulator
E3H47_08770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E3H47_08780	COG4122	O-methyltransferase activity
E3H47_08795	COG1739	Uncharacterized protein family UPF0029
E3H47_08810	COG1538	Outer membrane efflux protein
E3H47_08815	COG1137	ATPase activity
E3H47_08820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E3H47_08830	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E3H47_08835	COG0517	IMP dehydrogenase activity
E3H47_08835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E3H47_08850	COG1683	Conserved Protein
E3H47_08860	COG1228	amidohydrolase
E3H47_08870	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E3H47_08895	COG0830	nickel cation binding
E3H47_08915	COG0804	urea catabolic process
E3H47_08930	COG0829	nickel cation binding
E3H47_08945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3H47_08970	COG4232	protein-disulfide reductase activity
E3H47_08975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3H47_08980	COG1012	belongs to the aldehyde dehydrogenase family
E3H47_08985	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3H47_08990	COG1012	belongs to the aldehyde dehydrogenase family
E3H47_09010	COG0531	amino acid
E3H47_09015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3H47_09035	COG1643	Atp-dependent helicase
E3H47_09040	COG0450	alkyl hydroperoxide reductase
E3H47_09060	COG3634	alkyl hydroperoxide reductase activity
E3H47_09095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E3H47_09105	COG0318	PFAM AMP-dependent synthetase and ligase
E3H47_09110	COG1960	acyl-CoA dehydrogenase activity
E3H47_09115	COG1301	dicarboxylic acid transport
E3H47_09130	COG3139	Protein of unknown function (DUF1315)
E3H47_09135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E3H47_09140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3H47_09150	COG0494	nUDIX hydrolase
E3H47_09160	COG0642	Histidine kinase
E3H47_09165	COG0745	RESPONSE REGULATOR receiver
E3H47_09170	COG3111	PFAM Bacterial OB fold (BOF) protein
E3H47_09180	COG2203	Gaf domain
E3H47_09180	COG2199	diguanylate cyclase activity
E3H47_09185	COG1720	tRNA m6t6A37 methyltransferase activity
E3H47_09200	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3H47_09205	COG3634	alkyl hydroperoxide reductase activity
E3H47_09225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3H47_09265	COG1131	(ABC) transporter
E3H47_09270	COG0842	Transport permease protein
E3H47_09285	COG0772	Belongs to the SEDS family
E3H47_09290	COG2951	lytic endotransglycosylase activity
E3H47_09310	COG0052	Belongs to the universal ribosomal protein uS2 family
E3H47_09315	COG0024	Methionine aminopeptidase
E3H47_09330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3H47_09335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E3H47_09350	COG2391	methyltransferase activity
E3H47_09385	COG3706	GGDEF domain
E3H47_09390	COG1253	flavin adenine dinucleotide binding
E3H47_09415	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E3H47_09445	COG3040	lipid binding
E3H47_09450	COG0556	nucleotide-excision repair
E3H47_09460	COG2199	diguanylate cyclase activity
E3H47_09470	COG1733	regulation of RNA biosynthetic process
E3H47_09495	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E3H47_09500	COG1381	Involved in DNA repair and RecF pathway recombination
E3H47_09510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E3H47_09515	COG0571	ribonuclease III activity
E3H47_09525	COG0681	Belongs to the peptidase S26 family
E3H47_09540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3H47_09555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E3H47_09560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3H47_09565	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E3H47_09575	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E3H47_09580	COG4208	sulfate ABC transporter
E3H47_09585	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E3H47_09590	COG0583	DNA-binding transcription factor activity
E3H47_09605	COG0602	queuosine metabolic process
E3H47_09610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E3H47_09620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E3H47_09625	COG1056	cytidyltransferase-related domain
E3H47_09625	COG1051	belongs to the nudix hydrolase family
E3H47_09630	COG1024	Enoyl-CoA hydratase
E3H47_09640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E3H47_09645	COG0300	oxidoreductase activity
E3H47_09650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3H47_09650	COG0047	phosphoribosylformylglycinamidine synthase activity
E3H47_09665	COG2255	four-way junction helicase activity
E3H47_09670	COG2072	flavoprotein involved in K transport
E3H47_09685	COG0824	Thioesterase
E3H47_09705	COG0823	Involved in the tonB-independent uptake of proteins
E3H47_09725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3H47_09765	COG0628	permease
E3H47_09770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E3H47_09775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E3H47_09795	COG0658	competence protein
E3H47_09795	COG2333	competence protein COMEC
E3H47_09800	COG1136	(ABC) transporter
E3H47_09820	COG1671	Belongs to the UPF0178 family
E3H47_09840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3H47_09870	COG1280	lysine exporter protein (LysE YggA)
E3H47_09890	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E3H47_09895	COG0019	diaminopimelate decarboxylase activity
E3H47_09905	COG1113	amino acid transport
E3H47_09930	COG0174	glutamine synthetase
E3H47_09935	COG0745	RESPONSE REGULATOR receiver
E3H47_09950	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E3H47_09955	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E3H47_09965	COG0833	amino acid
E3H47_09975	COG3724	N-succinylarginine dihydrolase activity
E3H47_09980	COG1012	belongs to the aldehyde dehydrogenase family
E3H47_09985	COG3138	arginine N-succinyltransferase
E3H47_09990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3H47_09995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3H47_10010	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3H47_10010	COG1902	pentaerythritol trinitrate reductase activity
E3H47_10015	COG0277	FAD linked oxidase domain protein
E3H47_10025	COG2186	Transcriptional regulator
E3H47_10040	COG2203	Gaf domain
E3H47_10040	COG3706	GGDEF domain
E3H47_10040	COG4251	negative regulation of phosphorylation
E3H47_10040	COG5001	Diguanylate cyclase
E3H47_10045	COG0418	dihydroorotase activity
E3H47_10050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3H47_10065	COG0833	amino acid
E3H47_10085	COG4172	Belongs to the ABC transporter superfamily
E3H47_10090	COG4239	(ABC) transporter, permease
E3H47_10095	COG4174	ABC transporter (Permease)
E3H47_10100	COG4166	transmembrane transport
E3H47_10105	COG0741	lytic transglycosylase activity
E3H47_10105	COG1388	LysM domain
E3H47_10105	COG1388	LysM domain
E3H47_10105	COG0741	lytic transglycosylase activity
E3H47_10110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3H47_10120	COG2816	NAD+ diphosphatase activity
E3H47_10140	COG3107	peptidoglycan biosynthetic process
E3H47_10155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3H47_10160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3H47_10165	COG0006	proline dipeptidase activity
E3H47_10190	COG1522	sequence-specific DNA binding
E3H47_10210	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3H47_10215	COG1917	Cupin 2, conserved barrel domain protein
E3H47_10215	COG2169	Transcriptional regulator
E3H47_10230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3H47_10240	COG2234	aminopeptidase activity
E3H47_10245	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E3H47_10250	COG3384	dioxygenase
E3H47_10260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3H47_10265	COG2878	Part of a membrane complex involved in electron transport
E3H47_10270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3H47_10295	COG0768	penicillin binding
E3H47_10300	COG0742	ribosomal rna small subunit methyltransferase
E3H47_10315	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_10345	COG1253	flavin adenine dinucleotide binding
E3H47_10360	COG0584	glycerophosphoryl diester phosphodiesterase
E3H47_10370	COG0175	sulfate reduction
E3H47_10390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3H47_10395	COG1773	rubredoxin
E3H47_10400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3H47_10410	COG0583	DNA-binding transcription factor activity
E3H47_10430	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E3H47_10435	COG4181	ATPase activity
E3H47_10445	COG0288	reversible hydration of carbon dioxide
E3H47_10480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E3H47_10490	COG0306	phosphate transporter
E3H47_10510	COG0477	Major facilitator Superfamily
E3H47_10525	COG0477	Major facilitator Superfamily
E3H47_10555	COG1285	pathogenesis
E3H47_10560	COG4681	YaeQ
E3H47_10565	COG0523	cobalamin synthesis protein
E3H47_10575	COG1607	acyl-coa hydrolase
E3H47_10590	COG1309	transcriptional regulator
E3H47_10595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3H47_10605	COG1741	Belongs to the pirin family
E3H47_10615	COG2132	Multicopper oxidase
E3H47_10630	COG0625	glutathione transferase activity
E3H47_10650	COG2031	fatty acid transporter
E3H47_10655	COG0183	Belongs to the thiolase family
E3H47_10665	COG0589	response to stress
E3H47_10710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E3H47_10715	COG2814	Major facilitator Superfamily
E3H47_10720	COG1566	PFAM secretion protein HlyD family protein
E3H47_10730	COG2050	protein possibly involved in aromatic compounds catabolism
E3H47_10740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3H47_10745	COG1090	epimerase
E3H47_10755	COG0420	3'-5' exonuclease activity
E3H47_10780	COG0735	belongs to the Fur family
E3H47_10785	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3H47_10805	COG0121	glutamine amidotransferase
E3H47_10815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3H47_10820	COG0756	dUTP diphosphatase activity
E3H47_10830	COG2885	chlorophyll binding
E3H47_10835	COG0204	Acyl-transferase
E3H47_10850	COG2894	cell division
E3H47_10855	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E3H47_10865	COG1674	ftsk spoiiie
E3H47_10870	COG0492	ferredoxin-NADP+ reductase activity
E3H47_10875	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E3H47_10885	COG0456	acetyltransferase
E3H47_10935	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E3H47_10935	COG0352	thiamine-phosphate diphosphorylase activity
E3H47_10935	COG0351	phosphomethylpyrimidine kinase
E3H47_10940	COG1652	LysM domain
E3H47_10950	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_10965	COG1399	metal-binding, possibly nucleic acid-binding protein
E3H47_10970	COG3101	peptidyl-lysine hydroxylation
E3H47_10975	COG0009	L-threonylcarbamoyladenylate synthase
E3H47_10985	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E3H47_10990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E3H47_11005	COG4106	trans-aconitate 2-methyltransferase activity
E3H47_11020	COG0596	Alpha beta hydrolase
E3H47_11020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3H47_11020	COG2226	methyltransferase
E3H47_11025	COG2193	ferroxidase activity
E3H47_11035	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E3H47_11040	COG2223	nitrite transmembrane transporter activity
E3H47_11045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E3H47_11055	COG1196	nuclear chromosome segregation
E3H47_11065	COG0730	response to heat
E3H47_11080	COG3545	Serine hydrolase
E3H47_11085	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3H47_11095	COG2226	methyltransferase
E3H47_11100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3H47_11130	COG0564	pseudouridine synthase activity
E3H47_11160	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E3H47_11165	COG0354	folic acid binding
E3H47_11175	COG1902	pentaerythritol trinitrate reductase activity
E3H47_11180	COG2094	Belongs to the DNA glycosylase MPG family
E3H47_11190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3H47_11195	COG1970	mechanosensitive ion channel activity
E3H47_11205	COG2233	PERMEase
E3H47_11215	COG0833	amino acid
E3H47_11220	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E3H47_11220	COG2885	chlorophyll binding
E3H47_11230	COG0183	Belongs to the thiolase family
E3H47_11270	COG1376	ErfK ybiS ycfS ynhG family protein
E3H47_11275	COG2832	Protein of unknown function (DUF454)
E3H47_11285	COG5510	response to toxic substance
E3H47_11290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3H47_11300	COG0643	Histidine kinase
E3H47_11300	COG2198	Histidine kinase
E3H47_11305	COG0840	transmembrane signaling receptor activity
E3H47_11340	COG0442	prolyl-tRNA aminoacylation
E3H47_11375	COG0489	protein tyrosine kinase activity
E3H47_11380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3H47_11380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3H47_11415	COG2081	HI0933 family
E3H47_11425	COG0668	transmembrane transport
E3H47_11445	COG0583	DNA-binding transcription factor activity
E3H47_11460	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3H47_11465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3H47_11470	COG0713	ATP synthesis coupled electron transport
E3H47_11480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3H47_11495	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E3H47_11515	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3H47_11530	COG2205	protein histidine kinase activity
E3H47_11535	COG0745	RESPONSE REGULATOR receiver
E3H47_11555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3H47_11560	COG0583	DNA-binding transcription factor activity
E3H47_11565	COG4773	Receptor
E3H47_11580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3H47_11590	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3H47_11615	COG1968	undecaprenyl-diphosphatase activity
E3H47_11620	COG1214	PFAM Peptidase M22, glycoprotease
E3H47_11625	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E3H47_11630	COG0494	nUDIX hydrolase
E3H47_11670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3H47_11680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E3H47_11685	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E3H47_11690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E3H47_11760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E3H47_11775	COG0450	alkyl hydroperoxide reductase
E3H47_11790	COG0285	dihydrofolate synthase activity
E3H47_11795	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E3H47_11830	COG0133	tryptophan synthase activity
E3H47_11840	COG4206	TonB-dependent receptor
E3H47_11845	COG2096	Adenosyltransferase
E3H47_11865	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E3H47_11870	COG0745	RESPONSE REGULATOR receiver
E3H47_11875	COG2205	protein histidine kinase activity
E3H47_11885	COG1960	acyl-CoA dehydrogenase activity
E3H47_11890	COG1960	acyl-CoA dehydrogenase activity
E3H47_11895	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E3H47_11900	COG1162	GTPase activity
E3H47_11910	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3H47_11915	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E3H47_11920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3H47_11925	COG2003	Belongs to the UPF0758 family
E3H47_11930	COG3781	membrane
E3H47_11945	COG2350	Protein conserved in bacteria
E3H47_11965	COG1666	GTP binding
E3H47_11975	COG1607	acyl-coa hydrolase
E3H47_11985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3H47_11985	COG3453	Protein conserved in bacteria
E3H47_12040	COG1183	phosphatidylcholine synthase activity
E3H47_12045	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E3H47_12075	COG0739	heme binding
E3H47_12075	COG1196	nuclear chromosome segregation
E3H47_12075	COG0741	lytic transglycosylase activity
E3H47_12080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3H47_12085	COG1702	phosphate starvation-inducible protein PhoH
E3H47_12090	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E3H47_12125	COG1295	ribonuclease BN
E3H47_12130	COG0179	Fumarylacetoacetate (FAA) hydrolase
E3H47_12165	COG0557	exoribonuclease II activity
E3H47_12170	COG0339	signal peptide processing
E3H47_12175	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E3H47_12205	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E3H47_12210	COG1960	acyl-CoA dehydrogenase activity
E3H47_12215	COG2072	flavoprotein involved in K transport
E3H47_12220	COG0203	ribosomal protein L17
E3H47_12225	COG0202	RNA polymerase activity
E3H47_12230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E3H47_12235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E3H47_12245	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E3H47_12265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E3H47_12280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E3H47_12295	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E3H47_12300	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E3H47_12305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E3H47_12320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E3H47_12330	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E3H47_12340	COG0089	rRNA binding
E3H47_12345	COG0088	Forms part of the polypeptide exit tunnel
E3H47_12350	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E3H47_12365	COG0626	cystathionine gamma-synthase activity
E3H47_12370	COG1017	nitric oxide dioxygenase activity
E3H47_12370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3H47_12375	COG1959	2 iron, 2 sulfur cluster binding
E3H47_12385	COG1301	dicarboxylic acid transport
E3H47_12390	COG1946	Acyl-CoA thioesterase
E3H47_12395	COG2937	Belongs to the GPAT DAPAT family
E3H47_12405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E3H47_12410	COG1040	competence protein
E3H47_12425	COG0598	Magnesium transport protein CorA
E3H47_12435	COG2854	intermembrane phospholipid transfer
E3H47_12440	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E3H47_12445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E3H47_12450	COG1127	ABC transporter
E3H47_12465	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E3H47_12475	COG0408	coproporphyrinogen oxidase activity
E3H47_12495	COG1960	acyl-CoA dehydrogenase activity
E3H47_12505	COG1983	PspC domain protein
E3H47_12520	COG0752	glycyl-tRNA synthetase alpha subunit
E3H47_12525	COG0751	glycine-tRNA ligase activity
E3H47_12545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3H47_12585	COG0628	permease
E3H47_12590	COG2032	superoxide dismutase activity
E3H47_12605	COG0277	FAD linked oxidase domain protein
E3H47_12610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3H47_12615	COG5006	permease, DMT superfamily
E3H47_12620	COG5006	permease, DMT superfamily
E3H47_12635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E3H47_12640	COG5380	lipid catabolic process
E3H47_12645	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E3H47_12655	COG0335	large ribosomal subunit rRNA binding
E3H47_12665	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E3H47_12670	COG0228	four-way junction DNA binding
E3H47_12715	COG0194	GDP metabolic process
E3H47_12720	COG1758	RNA polymerase activity
E3H47_12725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3H47_12735	COG2906	2 iron, 2 sulfur cluster binding
E3H47_12775	COG0463	Glycosyl transferase, family 2
E3H47_12795	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E3H47_12800	COG1704	LemA family
E3H47_12810	COG0493	'glutamate synthase
E3H47_12815	COG0070	glutamate synthase
E3H47_12815	COG0069	glutamate synthase activity
E3H47_12815	COG0067	glutamate synthase
E3H47_12865	COG2226	methyltransferase
E3H47_12875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3H47_12880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3H47_12895	COG0275	rRNA processing
E3H47_12900	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E3H47_12910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3H47_12935	COG0488	(ABC) transporter
E3H47_12945	COG4221	oxidoreductase activity
E3H47_12965	COG0745	RESPONSE REGULATOR receiver
E3H47_12970	COG2205	protein histidine kinase activity
E3H47_12975	COG0427	acetyl-CoA hydrolase
E3H47_13005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E3H47_13020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E3H47_13025	COG0697	spore germination
E3H47_13040	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E3H47_13045	COG0107	imidazoleglycerol-phosphate synthase activity
E3H47_13100	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E3H47_13130	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_13140	COG1196	nuclear chromosome segregation
E3H47_13175	COG0629	single-stranded DNA binding
E3H47_13180	COG2814	Major facilitator Superfamily
E3H47_13195	COG0351	phosphomethylpyrimidine kinase
E3H47_13195	COG0352	thiamine-phosphate diphosphorylase activity
E3H47_13195	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E3H47_13215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3H47_13235	COG3162	membrane
E3H47_13240	COG2205	protein histidine kinase activity
E3H47_13240	COG0784	Response regulator, receiver
E3H47_13240	COG2198	Histidine kinase
E3H47_13270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3H47_13275	COG3152	Membrane
E3H47_13280	COG0668	transmembrane transport
E3H47_13290	COG1519	Transferase
E3H47_13295	COG1902	pentaerythritol trinitrate reductase activity
E3H47_13310	COG0586	Pfam SNARE associated Golgi protein
E3H47_13325	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3H47_13350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3H47_13350	COG0426	domain, Protein
E3H47_13355	COG2119	membrane
E3H47_13385	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E3H47_13395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E3H47_13405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3H47_13415	COG2814	Major facilitator Superfamily
E3H47_13425	COG0189	ligase activity
E3H47_13435	COG0708	Exodeoxyribonuclease III
E3H47_13460	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E3H47_13460	COG0666	response to abiotic stimulus
E3H47_13480	COG3150	esterase
E3H47_13495	COG2918	glutathione biosynthetic process
E3H47_13515	COG0436	Aminotransferase
E3H47_13520	COG0534	Mate efflux family protein
E3H47_13545	COG0688	phosphatidylethanolamine metabolic process
E3H47_13565	COG0753	catalase activity
E3H47_13585	COG3830	Belongs to the UPF0237 family
E3H47_13585	COG0560	Phosphoserine phosphatase
E3H47_13600	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E3H47_13605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3H47_13615	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E3H47_13625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E3H47_13630	COG0697	spore germination
E3H47_13635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3H47_13640	COG0385	Bile acid
E3H47_13645	COG1335	isochorismatase
E3H47_13650	COG2814	Major facilitator Superfamily
E3H47_13655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3H47_13675	COG2155	Conserved Protein
E3H47_13680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3H47_13685	COG2133	pyrroloquinoline quinone binding
E3H47_13690	COG0789	Transcriptional regulator
E3H47_13700	COG2983	Belongs to the UPF0260 family
E3H47_13705	COG5487	UPF0391 membrane protein
E3H47_13720	COG1194	a g-specific adenine glycosylase
E3H47_13735	COG2818	Glycosylase
E3H47_13740	COG1064	alcohol dehydrogenase
E3H47_13755	COG0583	DNA-binding transcription factor activity
E3H47_13760	COG0656	L-ascorbic acid biosynthetic process
E3H47_13765	COG2814	Major facilitator Superfamily
E3H47_13805	COG1309	transcriptional regulator
E3H47_13815	COG2233	PERMEase
E3H47_13830	COG0546	phosphoglycolate phosphatase activity
E3H47_13840	COG0129	dihydroxy-acid dehydratase activity
E3H47_13855	COG0428	transporter
E3H47_13865	COG0733	neurotransmitter:sodium symporter activity
E3H47_13915	COG1846	Transcriptional regulator
E3H47_13950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E3H47_13975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E3H47_13990	COG2951	lytic endotransglycosylase activity
E3H47_13995	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E3H47_14010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3H47_14015	COG0318	PFAM AMP-dependent synthetase and ligase
E3H47_14020	COG1960	acyl-CoA dehydrogenase activity
E3H47_14030	COG2814	Major facilitator Superfamily
E3H47_14040	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3H47_14055	COG0402	S-adenosylhomocysteine deaminase activity
E3H47_14070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3H47_14075	COG1230	cation diffusion facilitator family transporter
E3H47_14090	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E3H47_14095	COG0706	membrane insertase activity
E3H47_14100	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E3H47_14105	COG0594	ribonuclease P activity
E3H47_14110	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E3H47_14155	COG1373	ATPase (AAA superfamily
E3H47_14245	COG2132	Multicopper oxidase
E3H47_14285	COG2132	Multicopper oxidase
E3H47_14300	COG2205	protein histidine kinase activity
E3H47_14305	COG3174	membrane
E3H47_14310	COG2217	Heavy metal translocating P-type atpase
E3H47_14365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3H47_14375	COG1063	alcohol dehydrogenase
E3H47_14385	COG3316	Transposase and inactivated derivatives
E3H47_14455	COG3077	Addiction module antitoxin, RelB DinJ family
E3H47_14465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E3H47_14475	COG0640	Transcriptional regulator
E3H47_14485	COG0798	PFAM Bile acid sodium symporter
E3H47_14490	COG0431	NADPH-dependent FMN reductase
E3H47_14495	COG0492	ferredoxin-NADP+ reductase activity
E3H47_14525	COG3316	Transposase and inactivated derivatives
E3H47_14545	COG0642	Histidine kinase
E3H47_14550	COG0745	RESPONSE REGULATOR receiver
E3H47_14555	COG2194	sulfuric ester hydrolase activity
E3H47_14585	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E3H47_14600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3H47_14640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3H47_14650	COG0745	RESPONSE REGULATOR receiver
E3H47_14655	COG0642	Histidine kinase
E3H47_14665	COG2801	Transposase and inactivated derivatives
E3H47_14680	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
E3H47_14760	COG3451	type IV secretory pathway VirB4
E3H47_14780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3H47_14835	COG1192	Involved in chromosome partitioning
E3H47_14870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3H47_14905	COG3316	Transposase and inactivated derivatives
E3H47_14970	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E3H47_14980	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3H47_14990	COG2026	Addiction module toxin, RelE StbE family
E3H47_15010	COG2072	flavoprotein involved in K transport
E3H47_15020	COG2144	transferase activity, transferring acyl groups
E3H47_15045	COG3604	Transcriptional regulator
E3H47_15050	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E3H47_15080	COG1192	Involved in chromosome partitioning
E3H47_15135	COG0582	viral genome integration into host DNA
E3H47_15150	COG3485	protocatechuate 3,4-dioxygenase
E3H47_15155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E3H47_15160	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E3H47_15165	COG0583	DNA-binding transcription factor activity
E3H47_15170	COG4948	Mandelate Racemase Muconate Lactonizing
E3H47_15175	COG4829	muconolactone delta-isomerase
E3H47_15180	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E3H47_15185	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E3H47_15190	COG0183	Belongs to the thiolase family
E3H47_15195	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3H47_15205	COG4680	protein conserved in bacteria
E3H47_15260	COG1309	transcriptional regulator
E3H47_15295	COG0633	Ferredoxin
E3H47_15300	COG2207	Transcriptional regulator
E3H47_15355	COG2871	sodium ion transport