locus-tag	class	description
IC778_00010	COG0592	DNA-directed DNA polymerase activity
IC778_00020	COG0187	DNA topoisomerase II activity
IC778_00030	COG0586	Pfam SNARE associated Golgi protein
IC778_00035	COG0488	(ABC) transporter
IC778_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IC778_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IC778_00110	COG1047	Peptidyl-prolyl cis-trans
IC778_00120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IC778_00125	COG0196	riboflavin kinase activity
IC778_00135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IC778_00140	COG1309	transcriptional regulator
IC778_00145	COG1116	anion transmembrane transporter activity
IC778_00150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IC778_00155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IC778_00160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IC778_00165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IC778_00170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IC778_00170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IC778_00185	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_00190	COG0546	phosphoglycolate phosphatase activity
IC778_00245	COG3023	N-Acetylmuramoyl-L-alanine amidase
IC778_00250	COG0728	peptidoglycan biosynthetic process
IC778_00275	COG1596	polysaccharide export
IC778_00280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IC778_00290	COG1091	dTDP-4-dehydrorhamnose reductase activity
IC778_00295	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IC778_00305	COG1086	Polysaccharide biosynthesis protein
IC778_00340	COG0463	Glycosyl transferase, family 2
IC778_00340	COG1216	Glycosyl transferase, family 2
IC778_00345	COG0110	maltose O-acetyltransferase activity
IC778_00360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IC778_00365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IC778_00385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IC778_00395	COG2186	Transcriptional regulator
IC778_00405	COG0277	FAD linked oxidase domain protein
IC778_00410	COG1448	Aminotransferase
IC778_00420	COG1802	Transcriptional regulator
IC778_00435	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IC778_00505	COG0564	pseudouridine synthase activity
IC778_00545	COG0251	oxidation-reduction process
IC778_00550	COG1113	amino acid transport
IC778_00555	COG1113	amino acid transport
IC778_00575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IC778_00580	COG1960	acyl-CoA dehydrogenase activity
IC778_00585	COG1024	Enoyl-CoA hydratase
IC778_00590	COG1024	Enoyl-CoA hydratase
IC778_00595	COG0477	Major facilitator Superfamily
IC778_00600	COG3916	Acyl-homoserine-lactone synthase
IC778_00610	COG2197	response regulator
IC778_00620	COG1960	acyl-CoA dehydrogenase activity
IC778_00625	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IC778_00625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IC778_00625	COG3321	synthase
IC778_00625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IC778_00665	COG0271	Belongs to the BolA IbaG family
IC778_00675	COG1192	Involved in chromosome partitioning
IC778_00690	COG0586	Pfam SNARE associated Golgi protein
IC778_00695	COG2259	Doxx family
IC778_00700	COG4399	Belongs to the UPF0754 family
IC778_00700	COG4399	Belongs to the UPF0754 family
IC778_00705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IC778_00705	COG0519	Catalyzes the synthesis of GMP from XMP
IC778_00710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IC778_00720	COG0735	belongs to the Fur family
IC778_00755	COG0281	malic enzyme
IC778_00765	COG2826	transposase and inactivated derivatives, IS30 family
IC778_00775	COG1280	lysine exporter protein (LysE YggA)
IC778_00780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IC778_00785	COG1121	(ABC) transporter
IC778_00835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IC778_00840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IC778_00850	COG0386	Belongs to the glutathione peroxidase family
IC778_00865	COG1309	transcriptional regulator
IC778_00870	COG0697	spore germination
IC778_00880	COG0758	DNA mediated transformation
IC778_00915	COG1309	transcriptional regulator
IC778_00950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IC778_00965	COG0655	NAD(P)H dehydrogenase (quinone) activity
IC778_01000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IC778_01010	COG2814	Major facilitator Superfamily
IC778_01020	COG1253	flavin adenine dinucleotide binding
IC778_01030	COG2860	membrane
IC778_01035	COG0477	Major facilitator Superfamily
IC778_01045	COG0318	PFAM AMP-dependent synthetase and ligase
IC778_01060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IC778_01075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IC778_01080	COG0235	Class ii aldolase
IC778_01085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IC778_01090	COG0431	NADPH-dependent FMN reductase
IC778_01095	COG0606	chelatase, subunit chli
IC778_01105	COG0347	Belongs to the P(II) protein family
IC778_01110	COG0004	ammonium transporteR
IC778_01120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IC778_01120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IC778_01155	COG0795	lipopolysaccharide-transporting ATPase activity
IC778_01160	COG0795	lipopolysaccharide-transporting ATPase activity
IC778_01165	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IC778_01170	COG0793	Belongs to the peptidase S41A family
IC778_01185	COG2197	response regulator
IC778_01195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IC778_01205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IC778_01210	COG4974	Belongs to the 'phage' integrase family
IC778_01240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IC778_01245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IC778_01255	COG0494	nUDIX hydrolase
IC778_01275	COG0697	spore germination
IC778_01285	COG1538	Outer membrane efflux protein
IC778_01305	COG3275	phosphorelay sensor kinase activity
IC778_01315	COG0181	hydroxymethylbilane synthase activity
IC778_01360	COG1716	ATPase activity
IC778_01365	COG0546	phosphoglycolate phosphatase activity
IC778_01460	COG0596	Alpha beta hydrolase
IC778_01465	COG2056	Na+-H+ antiporter family
IC778_01480	COG0326	Molecular chaperone. Has ATPase activity
IC778_01495	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IC778_01555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IC778_01570	COG1289	transmembrane transporter activity
IC778_01585	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IC778_01595	COG0497	DNA recombination
IC778_01605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IC778_01615	COG0237	dephospho-CoA kinase activity
IC778_01665	COG0195	Participates in both transcription termination and antitermination
IC778_01675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IC778_01680	COG1320	monovalent cation:proton antiporter activity
IC778_01685	COG2212	antiporter activity
IC778_01690	COG1863	multisubunit Na H antiporter MnhE subunit
IC778_01695	COG0651	ATP synthesis coupled electron transport
IC778_01700	COG1006	Multisubunit Na H antiporter MnhC subunit
IC778_01705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IC778_01705	COG2111	Na H antiporter
IC778_01720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IC778_01735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC778_01750	COG2226	methyltransferase
IC778_01775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IC778_01780	COG1074	ATP-dependent DNA helicase activity
IC778_01785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IC778_01790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IC778_01800	COG1185	polyribonucleotide nucleotidyltransferase activity
IC778_01805	COG0598	Magnesium transport protein CorA
IC778_01810	COG0789	Transcriptional regulator
IC778_01815	COG0484	heat shock protein binding
IC778_01825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IC778_01830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IC778_01830	COG0475	glutathione-regulated potassium exporter activity
IC778_01835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IC778_01860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IC778_01870	COG4535	Mg2 and Co2 transporter CorC
IC778_01885	COG0644	oxidoreductase
IC778_01885	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IC778_01895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IC778_01910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC778_01915	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IC778_01925	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IC778_01925	COG0493	'glutamate synthase
IC778_01955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IC778_01970	COG0534	Mate efflux family protein
IC778_01980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IC778_01985	COG4221	oxidoreductase activity
IC778_01990	COG0583	DNA-binding transcription factor activity
IC778_02005	COG0318	PFAM AMP-dependent synthetase and ligase
IC778_02010	COG1530	ribonuclease E activity
IC778_02025	COG2378	regulation of single-species biofilm formation
IC778_02030	COG0625	glutathione transferase activity
IC778_02040	COG0583	DNA-binding transcription factor activity
IC778_02085	COG0583	DNA-binding transcription factor activity
IC778_02110	COG0473	3-isopropylmalate dehydrogenase activity
IC778_02165	COG1301	dicarboxylic acid transport
IC778_02175	COG1560	Kdo2-lipid A biosynthetic process
IC778_02180	COG1280	lysine exporter protein (LysE YggA)
IC778_02190	COG0488	(ABC) transporter
IC778_02195	COG2900	Belongs to the SlyX family
IC778_02205	COG1733	regulation of RNA biosynthetic process
IC778_02230	COG0210	DNA helicase
IC778_02235	COG0724	RNA recognition motif
IC778_02255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IC778_02255	COG4651	solute:proton antiporter activity
IC778_02280	COG0788	formyltetrahydrofolate deformylase activity
IC778_02385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IC778_02385	COG2813	Specifically methylates the guanine in position
IC778_02395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IC778_02405	COG4774	siderophore transport
IC778_02415	COG0740	serine-type endopeptidase activity
IC778_02435	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IC778_02435	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IC778_02440	COG0280	phosphate acetyltransferase
IC778_02440	COG0857	belongs to the CobB CobQ family
IC778_02445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IC778_02455	COG0800	Aldolase
IC778_02465	COG3265	gluconokinase activity
IC778_02470	COG1012	belongs to the aldehyde dehydrogenase family
IC778_02495	COG0793	Belongs to the peptidase S41A family
IC778_02530	COG1426	Protein conserved in bacteria
IC778_02570	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IC778_02580	COG1162	GTPase activity
IC778_02585	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IC778_02600	COG1538	Outer membrane efflux protein
IC778_02605	COG0577	efflux transmembrane transporter activity
IC778_02605	COG1136	(ABC) transporter
IC778_02610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC778_02635	COG0028	Belongs to the TPP enzyme family
IC778_02640	COG0440	acetolactate synthase activity
IC778_02645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IC778_02680	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IC778_02695	COG0084	hydrolase, TatD family'
IC778_02705	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IC778_02715	COG0583	DNA-binding transcription factor activity
IC778_02725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IC778_02830	COG2814	Major facilitator Superfamily
IC778_02845	COG1230	cation diffusion facilitator family transporter
IC778_02870	COG2814	Major facilitator Superfamily
IC778_02880	COG0697	spore germination
IC778_02915	COG3622	Belongs to the hyi family
IC778_02920	COG2084	Dehydrogenase
IC778_02925	COG1024	Enoyl-CoA hydratase
IC778_02930	COG0784	Response regulator, receiver
IC778_02930	COG2205	protein histidine kinase activity
IC778_02930	COG5002	protein histidine kinase activity
IC778_02950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IC778_02960	COG3956	TIGRFAM MazG family protein
IC778_02965	COG1555	photosystem II stabilization
IC778_02970	COG0617	tRNA 3'-terminal CCA addition
IC778_02975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IC778_03000	COG3028	Belongs to the UPF0307 family
IC778_03005	COG0318	PFAM AMP-dependent synthetase and ligase
IC778_03020	COG0625	glutathione transferase activity
IC778_03025	COG1238	metal cluster binding
IC778_03035	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IC778_03065	COG0072	phenylalanine-tRNA ligase activity
IC778_03095	COG0248	Ppx GppA phosphatase
IC778_03105	COG0037	tRNA processing
IC778_03145	COG1764	response to oxidative stress
IC778_03150	COG1846	Transcriptional regulator
IC778_03160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IC778_03220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IC778_03225	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IC778_03230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IC778_03240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IC778_03290	COG1214	PFAM Peptidase M22, glycoprotease
IC778_03305	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IC778_03315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IC778_03320	COG0561	phosphatase activity
IC778_03330	COG2132	Multicopper oxidase
IC778_03355	COG2826	transposase and inactivated derivatives, IS30 family
IC778_03365	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IC778_03370	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IC778_03400	COG1063	alcohol dehydrogenase
IC778_03405	COG0583	DNA-binding transcription factor activity
IC778_03410	COG1960	acyl-CoA dehydrogenase activity
IC778_03415	COG2814	Major facilitator Superfamily
IC778_03420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IC778_03430	COG1309	transcriptional regulator
IC778_03445	COG1053	succinate dehydrogenase
IC778_03450	COG0583	DNA-binding transcription factor activity
IC778_03465	COG0583	DNA-binding transcription factor activity
IC778_03475	COG0583	DNA-binding transcription factor activity
IC778_03490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC778_03535	COG0583	DNA-binding transcription factor activity
IC778_03540	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IC778_03570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IC778_03590	COG0745	RESPONSE REGULATOR receiver
IC778_03605	COG3706	GGDEF domain
IC778_03630	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IC778_03645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IC778_03660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IC778_03665	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IC778_03690	COG0583	DNA-binding transcription factor activity
IC778_03710	COG0668	transmembrane transport
IC778_03720	COG2081	HI0933 family
IC778_03725	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IC778_03760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IC778_03760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IC778_03770	COG0489	protein tyrosine kinase activity
IC778_03775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IC778_03820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IC778_03830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IC778_03845	COG0730	response to heat
IC778_03855	COG1196	nuclear chromosome segregation
IC778_03875	COG2223	nitrite transmembrane transporter activity
IC778_03880	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IC778_03885	COG1877	trehalose-phosphatase activity
IC778_03890	COG0596	Alpha beta hydrolase
IC778_03890	COG2226	methyltransferase
IC778_03890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IC778_03905	COG4106	trans-aconitate 2-methyltransferase activity
IC778_03920	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IC778_03925	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IC778_03930	COG0009	L-threonylcarbamoyladenylate synthase
IC778_03935	COG3101	peptidyl-lysine hydroxylation
IC778_03940	COG1399	metal-binding, possibly nucleic acid-binding protein
IC778_03965	COG1652	LysM domain
IC778_03970	COG0352	thiamine-phosphate diphosphorylase activity
IC778_03970	COG0351	phosphomethylpyrimidine kinase
IC778_03970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IC778_03980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IC778_04010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IC778_04040	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IC778_04055	COG0358	DNA primase activity
IC778_04090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IC778_04110	COG0583	DNA-binding transcription factor activity
IC778_04115	COG0473	3-isopropylmalate dehydrogenase activity
IC778_04125	COG0657	acetylesterase activity
IC778_04130	COG4638	Rieske (2fe-2S)
IC778_04135	COG1012	belongs to the aldehyde dehydrogenase family
IC778_04155	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IC778_04155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IC778_04165	COG1981	membrane
IC778_04180	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IC778_04190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IC778_04210	COG0456	acetyltransferase
IC778_04220	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IC778_04225	COG0492	ferredoxin-NADP+ reductase activity
IC778_04230	COG1674	ftsk spoiiie
IC778_04235	COG1280	lysine exporter protein (LysE YggA)
IC778_04250	COG2894	cell division
IC778_04265	COG0204	Acyl-transferase
IC778_04270	COG2885	chlorophyll binding
IC778_04275	COG0210	DNA helicase
IC778_04285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IC778_04300	COG0121	glutamine amidotransferase
IC778_04315	COG2914	Belongs to the UPF0125 (RnfH) family
IC778_04320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IC778_04325	COG0735	belongs to the Fur family
IC778_04345	COG1968	undecaprenyl-diphosphatase activity
IC778_04355	COG0420	3'-5' exonuclease activity
IC778_04375	COG1090	epimerase
IC778_04390	COG2050	protein possibly involved in aromatic compounds catabolism
IC778_04400	COG2814	Major facilitator Superfamily
IC778_04405	COG0405	Gamma-glutamyltransferase
IC778_04465	COG3586	endonuclease activity
IC778_04495	COG2826	transposase and inactivated derivatives, IS30 family
IC778_04515	COG0477	Major facilitator Superfamily
IC778_04520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IC778_04540	COG0531	amino acid
IC778_04545	COG2040	homocysteine
IC778_04570	COG1309	transcriptional regulator
IC778_04575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IC778_04580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IC778_04590	COG1607	acyl-coa hydrolase
IC778_04600	COG0523	cobalamin synthesis protein
IC778_04610	COG4681	YaeQ
IC778_04620	COG0726	polysaccharide deacetylase
IC778_04620	COG1649	PFAM Uncharacterised BCR, COG1649
IC778_04625	COG1215	transferase activity, transferring glycosyl groups
IC778_04635	COG1024	Enoyl-CoA hydratase
IC778_04665	COG1414	Transcriptional regulator
IC778_04700	COG2271	Major facilitator Superfamily
IC778_04710	COG2267	carboxylic ester hydrolase activity
IC778_04715	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_04730	COG0028	Belongs to the TPP enzyme family
IC778_04745	COG0242	peptide deformylase activity
IC778_04750	COG2066	Belongs to the glutaminase family
IC778_04755	COG2207	Transcriptional regulator
IC778_04760	COG2223	nitrite transmembrane transporter activity
IC778_04795	COG0306	phosphate transporter
IC778_04815	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IC778_04860	COG4181	ATPase activity
IC778_04865	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IC778_04890	COG0583	DNA-binding transcription factor activity
IC778_04900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IC778_04905	COG1773	rubredoxin
IC778_04955	COG2851	Citrate transporter
IC778_04960	COG1253	flavin adenine dinucleotide binding
IC778_05000	COG0804	urea catabolic process
IC778_05010	COG0830	nickel cation binding
IC778_05030	COG0742	ribosomal rna small subunit methyltransferase
IC778_05035	COG0768	penicillin binding
IC778_05060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IC778_05065	COG2878	Part of a membrane complex involved in electron transport
IC778_05070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IC778_05080	COG3384	dioxygenase
IC778_05115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IC778_05145	COG1674	ftsk spoiiie
IC778_05475	COG0006	proline dipeptidase activity
IC778_05480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC778_05485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC778_05510	COG0583	DNA-binding transcription factor activity
IC778_05555	COG0741	lytic transglycosylase activity
IC778_05555	COG1388	LysM domain
IC778_05565	COG4174	ABC transporter (Permease)
IC778_05570	COG4239	(ABC) transporter, permease
IC778_05575	COG4172	Belongs to the ABC transporter superfamily
IC778_05600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IC778_05610	COG4251	negative regulation of phosphorylation
IC778_05610	COG5001	Diguanylate cyclase
IC778_05610	COG2203	Gaf domain
IC778_05610	COG3706	GGDEF domain
IC778_05620	COG0446	pyridine nucleotide-disulphide oxidoreductase
IC778_05620	COG1902	pentaerythritol trinitrate reductase activity
IC778_05635	COG0251	oxidation-reduction process
IC778_05645	COG0583	DNA-binding transcription factor activity
IC778_05665	COG4269	membrane
IC778_05715	COG1846	Transcriptional regulator
IC778_05765	COG1113	amino acid transport
IC778_05775	COG0531	amino acid
IC778_05795	COG1012	belongs to the aldehyde dehydrogenase family
IC778_05815	COG1113	amino acid transport
IC778_05835	COG0697	spore germination
IC778_05855	COG1960	acyl-CoA dehydrogenase activity
IC778_05865	COG1012	belongs to the aldehyde dehydrogenase family
IC778_05870	COG1024	Enoyl-CoA hydratase
IC778_05875	COG2814	Major facilitator Superfamily
IC778_05890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC778_05910	COG1944	ATP diphosphatase activity
IC778_05940	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IC778_05955	COG0583	DNA-binding transcription factor activity
IC778_05960	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IC778_05965	COG2072	flavoprotein involved in K transport
IC778_05980	COG1309	transcriptional regulator
IC778_05985	COG1741	Belongs to the pirin family
IC778_06000	COG2072	flavoprotein involved in K transport
IC778_06010	COG2252	PERMEase
IC778_06015	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IC778_06020	COG3038	cytochrome b561
IC778_06030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IC778_06040	COG0527	aspartate kinase activity
IC778_06050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IC778_06065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IC778_06080	COG0667	Aldo Keto reductase
IC778_06090	COG1765	OsmC-like protein
IC778_06105	COG0542	response to heat
IC778_06150	COG0625	glutathione transferase activity
IC778_06155	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IC778_06175	COG3634	alkyl hydroperoxide reductase activity
IC778_06195	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC778_06210	COG1643	Atp-dependent helicase
IC778_06230	COG2814	Major facilitator Superfamily
IC778_06235	COG3135	benzoate transporter
IC778_06240	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_06245	COG0633	Ferredoxin
IC778_06245	COG0543	2 iron, 2 sulfur cluster binding
IC778_06250	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IC778_06255	COG4638	Rieske (2fe-2S)
IC778_06265	COG0583	DNA-binding transcription factor activity
IC778_06275	COG2871	sodium ion transport
IC778_06360	COG1570	exodeoxyribonuclease VII activity
IC778_06395	COG1280	lysine exporter protein (LysE YggA)
IC778_06400	COG1278	Cold shock
IC778_06430	COG2814	Major facilitator Superfamily
IC778_06440	COG0667	Aldo Keto reductase
IC778_06460	COG0517	IMP dehydrogenase activity
IC778_06460	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IC778_06465	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IC778_06475	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IC778_06480	COG1137	ATPase activity
IC778_06485	COG1538	Outer membrane efflux protein
IC778_06515	COG4122	O-methyltransferase activity
IC778_06525	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IC778_06580	COG1560	Kdo2-lipid A biosynthetic process
IC778_06600	COG1469	GTP cyclohydrolase I activity
IC778_06610	COG1294	oxidase, subunit
IC778_06615	COG1271	oxidase subunit
IC778_06625	COG0583	DNA-binding transcription factor activity
IC778_06630	COG0402	S-adenosylhomocysteine deaminase activity
IC778_06645	COG2814	Major facilitator Superfamily
IC778_06665	COG4774	siderophore transport
IC778_06670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IC778_06680	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_06690	COG1522	sequence-specific DNA binding
IC778_06695	COG0626	cystathionine gamma-synthase activity
IC778_06705	COG1278	Cold shock
IC778_06710	COG1309	transcriptional regulator
IC778_06790	COG3209	COG3209 Rhs family protein
IC778_06805	COG2826	transposase and inactivated derivatives, IS30 family
IC778_06845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IC778_06850	COG3713	MltA-interacting MipA family protein
IC778_06865	COG2076	Multidrug Resistance protein
IC778_06880	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_06895	COG3220	belongs to the UPF0276 family
IC778_06905	COG1595	DNA-templated transcription, initiation
IC778_06915	COG0583	DNA-binding transcription factor activity
IC778_06920	COG1914	H( )-stimulated, divalent metal cation uptake system
IC778_06940	COG4770	biotin carboxylase activity
IC778_06945	COG0038	chloride channel
IC778_06995	COG1063	alcohol dehydrogenase
IC778_07010	COG0439	Biotin carboxylase
IC778_07015	COG2249	NAD(P)H dehydrogenase (quinone) activity
IC778_07020	COG1733	regulation of RNA biosynthetic process
IC778_07035	COG0864	Transcriptional regulator
IC778_07045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IC778_07050	COG1116	anion transmembrane transporter activity
IC778_07075	COG0477	Major facilitator Superfamily
IC778_07180	COG0590	tRNA wobble adenosine to inosine editing
IC778_07185	COG2807	transmembrane transport
IC778_07200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IC778_07205	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IC778_07215	COG0789	Transcriptional regulator
IC778_07225	COG1760	l-serine dehydratase
IC778_07230	COG1012	belongs to the aldehyde dehydrogenase family
IC778_07230	COG2030	dehydratase
IC778_07235	COG3396	Phenylacetate-CoA oxygenase
IC778_07240	COG3460	Phenylacetate-CoA oxygenase
IC778_07245	COG3396	Phenylacetate-CoA oxygenase
IC778_07250	COG2151	metal-sulfur cluster biosynthetic enzyme
IC778_07255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC778_07260	COG1024	Enoyl-CoA hydratase
IC778_07265	COG1024	Enoyl-CoA hydratase
IC778_07270	COG1250	3-hydroxyacyl-CoA dehydrogenase
IC778_07280	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IC778_07285	COG3327	negative regulation of DNA-templated transcription, initiation
IC778_07295	COG2050	protein possibly involved in aromatic compounds catabolism
IC778_07305	COG0406	alpha-ribazole phosphatase activity
IC778_07325	COG3179	chitinase
IC778_07375	COG1309	transcriptional regulator
IC778_07380	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IC778_07395	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IC778_07400	COG0531	amino acid
IC778_07405	COG0753	catalase activity
IC778_07410	COG3038	cytochrome b561
IC778_07430	COG0583	DNA-binding transcription factor activity
IC778_07440	COG1414	Transcriptional regulator
IC778_07445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC778_07460	COG1840	ABC-type Fe3 transport system, periplasmic component
IC778_07465	COG3842	ATPase activity
IC778_07480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IC778_07485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IC778_07490	COG2814	Major facilitator Superfamily
IC778_07495	COG1960	acyl-CoA dehydrogenase activity
IC778_07500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IC778_07510	COG1024	Enoyl-CoA hydratase
IC778_07535	COG0183	Belongs to the thiolase family
IC778_07540	COG1250	3-hydroxyacyl-CoA dehydrogenase
IC778_07545	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_07550	COG1024	Enoyl-CoA hydratase
IC778_07555	COG1960	acyl-CoA dehydrogenase activity
IC778_07580	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IC778_07590	COG2814	Major facilitator Superfamily
IC778_07600	COG1960	acyl-CoA dehydrogenase activity
IC778_07615	COG0583	DNA-binding transcription factor activity
IC778_07625	COG4770	biotin carboxylase activity
IC778_07630	COG1024	Enoyl-CoA hydratase
IC778_07635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IC778_07640	COG1960	acyl-CoA dehydrogenase activity
IC778_07645	COG1309	transcriptional regulator
IC778_07650	COG0318	PFAM AMP-dependent synthetase and ligase
IC778_07670	COG0583	DNA-binding transcription factor activity
IC778_07715	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_07735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IC778_07795	COG0765	amino acid transport
IC778_07800	COG0765	amino acid transport
IC778_07810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IC778_07815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IC778_07825	COG1280	lysine exporter protein (LysE YggA)
IC778_07830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IC778_07840	COG1045	serine acetyltransferase
IC778_07855	COG0583	DNA-binding transcription factor activity
IC778_07860	COG0625	glutathione transferase activity
IC778_07865	COG0625	glutathione transferase activity
IC778_07870	COG0583	DNA-binding transcription factor activity
IC778_07880	COG1346	cytolysis
IC778_07905	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
IC778_07910	COG3052	prosthetic group binding
IC778_07930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IC778_07950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IC778_07960	COG1294	oxidase, subunit
IC778_07965	COG1271	oxidase subunit
IC778_07985	COG0477	Major facilitator Superfamily
IC778_07995	COG4521	taurine ABC transporter
IC778_08000	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IC778_08005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IC778_08010	COG2175	clavaminate synthase activity
IC778_08020	COG1953	Uracil, thiamine, allantoin
IC778_08030	COG0583	DNA-binding transcription factor activity
IC778_08040	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IC778_08055	COG0640	Transcriptional regulator
IC778_08060	COG0798	PFAM Bile acid sodium symporter
IC778_08065	COG0431	NADPH-dependent FMN reductase
IC778_08070	COG0583	DNA-binding transcription factor activity
IC778_08085	COG3634	alkyl hydroperoxide reductase activity
IC778_08120	COG1301	dicarboxylic acid transport
IC778_08125	COG0436	Aminotransferase
IC778_08135	COG0386	Belongs to the glutathione peroxidase family
IC778_08140	COG2207	Transcriptional regulator
IC778_08140	COG1917	Cupin 2, conserved barrel domain protein
IC778_08175	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IC778_08200	COG0012	GTP binding
IC778_08205	COG2011	ABC-type metal ion transport system permease component
IC778_08210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IC778_08220	COG1464	Belongs to the NlpA lipoprotein family
IC778_08250	COG0765	amino acid transport
IC778_08255	COG0765	amino acid transport
IC778_08260	COG1126	abc transporter atp-binding protein
IC778_08270	COG1522	sequence-specific DNA binding
IC778_08295	COG2197	response regulator
IC778_08315	COG0583	DNA-binding transcription factor activity
IC778_08325	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IC778_08335	COG0697	spore germination
IC778_08355	COG3121	Chaperone
IC778_08360	COG3539	Fimbrial protein
IC778_08385	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IC778_08385	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IC778_08425	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IC778_08440	COG2353	YceI-like domain
IC778_08450	COG3698	Phosphodiester glycosidase
IC778_08465	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IC778_08470	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IC778_08470	COG0506	proline dehydrogenase activity
IC778_08470	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IC778_08480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IC778_08485	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IC778_08505	COG1132	(ABC) transporter
IC778_08510	COG3122	Protein conserved in bacteria
IC778_08515	COG3619	membrane
IC778_08535	COG2850	peptidyl-arginine hydroxylation
IC778_08540	COG0424	maF-like protein
IC778_08580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IC778_08590	COG1192	Involved in chromosome partitioning
IC778_08595	COG1475	DNA binding
IC778_08600	COG0811	peptide transport
IC778_08610	COG1132	(ABC) transporter
IC778_08635	COG0084	hydrolase, TatD family'
IC778_08700	COG0776	regulation of translation
IC778_08715	COG2431	L-lysine efflux transmembrane transporter activity
IC778_08730	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IC778_08780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IC778_08800	COG0305	Participates in initiation and elongation during chromosome replication
IC778_08880	COG4695	Portal protein
IC778_09000	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IC778_09025	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IC778_09050	COG0601	transmembrane transport
IC778_09055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IC778_09060	COG4172	Belongs to the ABC transporter superfamily
IC778_09090	COG0702	epimerase
IC778_09095	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IC778_09115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IC778_09145	COG0316	Belongs to the HesB IscA family
IC778_09150	COG0822	iron-sulfur transferase activity
IC778_09175	COG0776	regulation of translation
IC778_09180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IC778_09185	COG2207	Transcriptional regulator
IC778_09190	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC778_09195	COG1960	acyl-CoA dehydrogenase activity
IC778_09200	COG1960	acyl-CoA dehydrogenase activity
IC778_09215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IC778_09220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IC778_09235	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IC778_09240	COG0406	alpha-ribazole phosphatase activity
IC778_09255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IC778_09260	COG0730	response to heat
IC778_09280	COG4773	Receptor
IC778_09285	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IC778_09300	COG1131	(ABC) transporter
IC778_09305	COG0842	Transport permease protein
IC778_09310	COG0842	Transport permease protein
IC778_09360	COG2226	methyltransferase
IC778_09385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IC778_09410	COG2826	transposase and inactivated derivatives, IS30 family
IC778_09425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IC778_09435	COG0133	tryptophan synthase activity
IC778_09450	COG3706	GGDEF domain
IC778_09465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IC778_09470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IC778_09475	COG0022	dehydrogenase e1 component
IC778_09480	COG0508	dehydrogenase complex catalyzes the overall conversion of
IC778_09485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IC778_09495	COG1063	alcohol dehydrogenase
IC778_09500	COG3781	membrane
IC778_09510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC778_09510	COG3453	Protein conserved in bacteria
IC778_09520	COG0730	response to heat
IC778_09535	COG2207	Transcriptional regulator
IC778_09535	COG3708	Transcriptional regulator
IC778_09545	COG0477	Major facilitator Superfamily
IC778_09555	COG1027	Aspartate ammonia-lyase
IC778_09570	COG0583	DNA-binding transcription factor activity
IC778_09575	COG0583	DNA-binding transcription factor activity
IC778_09580	COG0183	Belongs to the thiolase family
IC778_09585	COG2031	fatty acid transporter
IC778_09600	COG0583	DNA-binding transcription factor activity
IC778_09625	COG2814	Major facilitator Superfamily
IC778_09655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC778_09660	COG2610	gluconate transmembrane transporter activity
IC778_09665	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_09670	COG2207	Transcriptional regulator
IC778_09690	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_09700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC778_09715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC778_09715	COG0543	2 iron, 2 sulfur cluster binding
IC778_09720	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IC778_09725	COG4638	Rieske (2fe-2S)
IC778_09735	COG0725	ABC transporter, periplasmic molybdate-binding protein
IC778_09740	COG4149	molybdate abc transporter
IC778_09745	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IC778_09770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IC778_09775	COG3251	PFAM MbtH domain protein
IC778_09785	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_09790	COG1169	isochorismate synthase
IC778_09795	COG1021	2,3-dihydroxybenzoate-AMP ligase
IC778_09800	COG3433	isochorismatase activity
IC778_09800	COG1535	isochorismatase
IC778_09805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC778_09810	COG4771	TonB-dependent receptor
IC778_09870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC778_09875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC778_09880	COG0745	RESPONSE REGULATOR receiver
IC778_09895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IC778_09900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IC778_09910	COG0753	catalase activity
IC778_09920	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IC778_09945	COG3539	Fimbrial protein
IC778_09975	COG0601	transmembrane transport
IC778_09980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IC778_10000	COG1132	(ABC) transporter
IC778_10005	COG1132	(ABC) transporter
IC778_10025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IC778_10035	COG0805	protein transport
IC778_10040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IC778_10055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IC778_10060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IC778_10065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IC778_10070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IC778_10100	COG4771	TonB-dependent receptor
IC778_10105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IC778_10110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IC778_10140	COG2175	clavaminate synthase activity
IC778_10155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IC778_10160	COG0667	Aldo Keto reductase
IC778_10175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IC778_10180	COG2175	clavaminate synthase activity
IC778_10275	COG2826	transposase and inactivated derivatives, IS30 family
IC778_10300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IC778_10320	COG1120	ATPase activity
IC778_10325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IC778_10355	COG1566	PFAM secretion protein HlyD family protein
IC778_10365	COG2271	Major facilitator Superfamily
IC778_10380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC778_10395	COG2188	Transcriptional regulator
IC778_10475	COG1309	transcriptional regulator
IC778_10500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IC778_10530	COG0583	DNA-binding transcription factor activity
IC778_10535	COG4948	Mandelate Racemase Muconate Lactonizing
IC778_10540	COG4829	muconolactone delta-isomerase
IC778_10550	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IC778_10555	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IC778_10560	COG0183	Belongs to the thiolase family
IC778_10565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IC778_10570	COG1012	belongs to the aldehyde dehydrogenase family
IC778_10585	COG3733	amine oxidase
IC778_10595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC778_10605	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_10615	COG4638	Rieske (2fe-2S)
IC778_10635	COG0154	amidase activity
IC778_10645	COG2814	Major facilitator Superfamily
IC778_10670	COG1960	acyl-CoA dehydrogenase activity
IC778_10675	COG0583	DNA-binding transcription factor activity
IC778_10680	COG1414	Transcriptional regulator
IC778_10695	COG2391	methyltransferase activity
IC778_10705	COG4993	Dehydrogenase
IC778_10710	COG3659	wide pore channel activity
IC778_10715	COG3420	alginic acid biosynthetic process
IC778_10720	COG0710	3-dehydroquinate dehydratase activity
IC778_10725	COG3485	protocatechuate 3,4-dioxygenase
IC778_10730	COG3485	protocatechuate 3,4-dioxygenase
IC778_10735	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IC778_10740	COG2271	Major facilitator Superfamily
IC778_10745	COG0596	Alpha beta hydrolase
IC778_10750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IC778_10755	COG0183	Belongs to the thiolase family
IC778_10760	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IC778_10765	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IC778_10775	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IC778_10785	COG2323	membrane
IC778_10790	COG0148	phosphopyruvate hydratase activity
IC778_10830	COG0446	pyridine nucleotide-disulphide oxidoreductase
IC778_10830	COG1902	pentaerythritol trinitrate reductase activity
IC778_10855	COG0542	response to heat
IC778_10860	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IC778_10890	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IC778_10895	COG0569	domain protein
IC778_10900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IC778_10915	COG4774	siderophore transport
IC778_10920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IC778_10930	COG1585	Membrane protein implicated in regulation of membrane protease activity
IC778_10945	COG1294	oxidase, subunit
IC778_10950	COG4890	Cyd operon protein YbgT
IC778_10975	COG0552	protein localization to endoplasmic reticulum
IC778_11000	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IC778_11005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IC778_11010	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IC778_11020	COG0583	DNA-binding transcription factor activity
IC778_11025	COG0024	Methionine aminopeptidase
IC778_11055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IC778_11055	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IC778_11060	COG1105	Belongs to the carbohydrate kinase PfkB family
IC778_11065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IC778_11065	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IC778_11065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IC778_11090	COG2826	transposase and inactivated derivatives, IS30 family
IC778_11110	COG0659	secondary active sulfate transmembrane transporter activity
IC778_11125	COG1113	amino acid transport
IC778_11135	COG1522	sequence-specific DNA binding
IC778_11150	COG1011	Hydrolase
IC778_11155	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IC778_11165	COG2137	regulation of response to DNA damage stimulus
IC778_11180	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IC778_11200	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IC778_11215	COG0575	Belongs to the CDS family
IC778_11220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IC778_11245	COG3852	Histidine kinase
IC778_11250	COG2204	response regulator
IC778_11305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IC778_11310	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IC778_11330	COG0697	spore germination
IC778_11345	COG0303	'Molybdopterin
IC778_11350	COG0315	cyclic pyranopterin monophosphate synthase activity
IC778_11350	COG0521	Mo-molybdopterin cofactor biosynthetic process
IC778_11365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IC778_11370	COG0243	molybdopterin cofactor binding
IC778_11380	COG0243	molybdopterin cofactor binding
IC778_11385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IC778_11390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IC778_11390	COG2146	nitrite reductase [NAD(P)H] activity
IC778_11400	COG0745	RESPONSE REGULATOR receiver
IC778_11405	COG1116	anion transmembrane transporter activity
IC778_11405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IC778_11425	COG0511	ligase activity, forming carbon-carbon bonds
IC778_11485	COG0069	glutamate synthase activity
IC778_11515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IC778_11530	COG1335	isochorismatase
IC778_11540	COG1454	alcohol dehydrogenase
IC778_11545	COG0824	Thioesterase
IC778_11555	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IC778_11580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IC778_11585	COG2030	dehydratase
IC778_11590	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_11595	COG0183	Belongs to the thiolase family
IC778_11605	COG0583	DNA-binding transcription factor activity
IC778_11610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IC778_11620	COG1522	sequence-specific DNA binding
IC778_11625	COG3135	benzoate transporter
IC778_11650	COG0589	response to stress
IC778_11655	COG0488	(ABC) transporter
IC778_11700	COG0668	transmembrane transport
IC778_11710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IC778_11715	COG2423	ornithine cyclodeaminase activity
IC778_11720	COG4264	IucA IucC family
IC778_11730	COG4264	IucA IucC family
IC778_11770	COG2826	transposase and inactivated derivatives, IS30 family
IC778_11780	COG1605	Chorismate mutase
IC778_11795	COG0625	glutathione transferase activity
IC778_11825	COG0308	aminopeptidase N
IC778_11845	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IC778_11855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IC778_11860	COG1454	alcohol dehydrogenase
IC778_11880	COG0531	amino acid
IC778_11885	COG4303	Ethanolamine ammonia lyase large subunit
IC778_11890	COG4302	ethanolamine ammonia-lyase activity
IC778_11895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IC778_11895	COG0519	Catalyzes the synthesis of GMP from XMP
IC778_11900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IC778_11925	COG0697	spore germination
IC778_11930	COG1923	regulation of RNA biosynthetic process
IC778_11940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IC778_11945	COG0802	atpase or kinase
IC778_11965	COG1187	pseudouridine synthase activity
IC778_11980	COG0583	DNA-binding transcription factor activity
IC778_11990	COG2814	Major facilitator Superfamily
IC778_11995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IC778_12025	COG0729	surface antigen
IC778_12045	COG0174	glutamine synthetase
IC778_12050	COG0745	RESPONSE REGULATOR receiver
IC778_12055	COG2205	protein histidine kinase activity
IC778_12060	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IC778_12065	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IC778_12070	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IC778_12095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC778_12100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IC778_12105	COG1960	acyl-CoA dehydrogenase activity
IC778_12120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IC778_12125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IC778_12130	COG2890	protein-(glutamine-N5) methyltransferase activity
IC778_12150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IC778_12160	COG3658	cytochrome
IC778_12165	COG1215	transferase activity, transferring glycosyl groups
IC778_12170	COG1649	PFAM Uncharacterised BCR, COG1649
IC778_12170	COG0726	polysaccharide deacetylase
IC778_12200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IC778_12210	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IC778_12235	COG0305	Participates in initiation and elongation during chromosome replication
IC778_12240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IC778_12250	COG1305	Transglutaminase-like
IC778_12260	COG2308	Evidence 4 Homologs of previously reported genes of
IC778_12290	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IC778_12295	COG0138	bifunctional purine biosynthesis protein purh
IC778_12300	COG0151	Belongs to the GarS family
IC778_12305	COG1464	Belongs to the NlpA lipoprotein family
IC778_12310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IC778_12315	COG2011	ABC-type metal ion transport system permease component
IC778_12330	COG1301	dicarboxylic acid transport
IC778_12375	COG2855	membrane
IC778_12390	COG2814	Major facilitator Superfamily
IC778_12395	COG3246	L-lysine catabolic process to acetate
IC778_12400	COG2175	clavaminate synthase activity
IC778_12425	COG0745	RESPONSE REGULATOR receiver
IC778_12430	COG0642	Histidine kinase
IC778_12435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IC778_12480	COG5002	protein histidine kinase activity
IC778_12495	COG2351	hydroxyisourate hydrolase activity
IC778_12505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IC778_12505	COG3008	intermembrane lipid transfer
IC778_12510	COG2995	paraquat-inducible protein a
IC778_12535	COG2985	domain, Protein
IC778_12550	COG2169	Transcriptional regulator
IC778_12550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IC778_12560	COG1309	transcriptional regulator
IC778_12635	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_12640	COG0475	glutathione-regulated potassium exporter activity
IC778_12640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IC778_12645	COG0786	glutamate:sodium symporter activity
IC778_12655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IC778_12665	COG0596	Alpha beta hydrolase
IC778_12685	COG0583	DNA-binding transcription factor activity
IC778_12690	COG1335	isochorismatase
IC778_12760	COG2826	transposase and inactivated derivatives, IS30 family
IC778_12800	COG0515	serine threonine protein kinase
IC778_12800	COG2815	serine threonine protein kinase
IC778_12830	COG1610	YqeY-like protein
IC778_12890	COG0778	Nitroreductase
IC778_12900	COG0513	Belongs to the DEAD box helicase family
IC778_12920	COG2363	Small membrane protein
IC778_12945	COG4650	regulator
IC778_12950	COG1234	tRNA 3'-trailer cleavage
IC778_12955	COG1690	Belongs to the RtcB family
IC778_12975	COG2195	Cleaves the N-terminal amino acid of tripeptides
IC778_12980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IC778_12990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IC778_13010	COG1960	acyl-CoA dehydrogenase activity
IC778_13015	COG1301	dicarboxylic acid transport
IC778_13025	COG3139	Protein of unknown function (DUF1315)
IC778_13030	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IC778_13035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IC778_13045	COG0494	nUDIX hydrolase
IC778_13055	COG0642	Histidine kinase
IC778_13070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IC778_13080	COG1720	tRNA m6t6A37 methyltransferase activity
IC778_13090	COG0384	phenazine biosynthesis protein PhzF
IC778_13095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IC778_13100	COG0826	peptidase U32
IC778_13105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IC778_13115	COG4598	ABC transporter
IC778_13120	COG4160	amino acid transport
IC778_13125	COG4215	(ABC) transporter
IC778_13140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC778_13180	COG1131	(ABC) transporter
IC778_13185	COG0842	Transport permease protein
IC778_13200	COG0772	Belongs to the SEDS family
IC778_13205	COG2951	lytic endotransglycosylase activity
IC778_13230	COG2207	Transcriptional regulator
IC778_13245	COG0052	Belongs to the universal ribosomal protein uS2 family
IC778_13250	COG0024	Methionine aminopeptidase
IC778_13260	COG2223	nitrite transmembrane transporter activity
IC778_13270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IC778_13275	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IC778_13280	COG1960	acyl-CoA dehydrogenase activity
IC778_13295	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IC778_13300	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IC778_13305	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IC778_13325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IC778_13330	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IC778_13335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IC778_13370	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IC778_13380	COG0174	glutamine synthetase
IC778_13395	COG0512	Glutamine amidotransferase of anthranilate synthase
IC778_13410	COG2840	Smr protein MutS2
IC778_13420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IC778_13430	COG0302	gtp cyclohydrolase
IC778_13450	COG3739	integral membrane protein
IC778_13465	COG1741	Belongs to the pirin family
IC778_13475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IC778_13480	COG2826	transposase and inactivated derivatives, IS30 family
IC778_13490	COG2964	Protein conserved in bacteria
IC778_13500	COG2423	ornithine cyclodeaminase activity
IC778_13505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IC778_13545	COG2814	Major facilitator Superfamily
IC778_13575	COG2879	small protein
IC778_13580	COG1966	Carbon starvation protein
IC778_13585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IC778_13600	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IC778_13625	COG1067	ATP-dependent peptidase activity
IC778_13630	COG0583	DNA-binding transcription factor activity
IC778_13655	COG1686	Belongs to the peptidase S11 family
IC778_13660	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IC778_13685	COG3647	Membrane
IC778_13700	COG0616	signal peptide processing
IC778_13705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IC778_13715	COG0573	inorganic phosphate transmembrane transporter activity
IC778_13720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IC778_13725	COG1113	amino acid transport
IC778_13730	COG3961	Belongs to the TPP enzyme family
IC778_13735	COG1522	sequence-specific DNA binding
IC778_13745	COG0076	glutamate decarboxylase activity
IC778_13750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IC778_13775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC778_13810	COG0352	thiamine-phosphate diphosphorylase activity
IC778_13845	COG0612	Peptidase, M16
IC778_13855	COG1823	symporter activity
IC778_13860	COG0583	DNA-binding transcription factor activity
IC778_13865	COG0477	Major facilitator Superfamily
IC778_13890	COG1187	pseudouridine synthase activity
IC778_13905	COG1686	Belongs to the peptidase S11 family
IC778_13910	COG1252	NADH dehydrogenase
IC778_13920	COG0415	Belongs to the DNA photolyase family
IC778_13935	COG1215	transferase activity, transferring glycosyl groups
IC778_13950	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IC778_13965	COG2070	2-Nitropropane dioxygenase
IC778_14020	COG0556	nucleotide-excision repair
IC778_14025	COG3706	GGDEF domain
IC778_14045	COG0436	Aminotransferase
IC778_14070	COG4221	oxidoreductase activity
IC778_14080	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IC778_14085	COG1381	Involved in DNA repair and RecF pathway recombination
IC778_14095	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IC778_14110	COG0681	Belongs to the peptidase S26 family
IC778_14115	COG0481	GTPase activity
IC778_14125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IC778_14145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IC778_14150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IC778_14155	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IC778_14165	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IC778_14170	COG4208	sulfate ABC transporter
IC778_14175	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IC778_14180	COG0583	DNA-binding transcription factor activity
IC778_14185	COG4625	pathogenesis
IC778_14195	COG0602	queuosine metabolic process
IC778_14200	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IC778_14215	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IC778_14230	COG1051	belongs to the nudix hydrolase family
IC778_14230	COG1056	cytidyltransferase-related domain
IC778_14235	COG1024	Enoyl-CoA hydratase
IC778_14240	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IC778_14260	COG2814	Major facilitator Superfamily
IC778_14265	COG0047	phosphoribosylformylglycinamidine synthase activity
IC778_14265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IC778_14290	COG1473	amidohydrolase
IC778_14295	COG0824	Thioesterase
IC778_14315	COG0823	Involved in the tonB-independent uptake of proteins
IC778_14335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IC778_14370	COG0628	permease
IC778_14380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IC778_14385	COG0596	Alpha beta hydrolase
IC778_14390	COG0616	signal peptide processing
IC778_14390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IC778_14400	COG0658	competence protein
IC778_14400	COG2333	competence protein COMEC
IC778_14405	COG1136	(ABC) transporter
IC778_14410	COG4591	ABC-type transport system involved in lipoprotein release permease component
IC778_14445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC778_14465	COG0463	Glycosyl transferase, family 2
IC778_14475	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IC778_14485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC778_14505	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IC778_14510	COG1280	lysine exporter protein (LysE YggA)
IC778_14525	COG0019	diaminopimelate decarboxylase activity
IC778_14535	COG1113	amino acid transport
IC778_14540	COG1115	amino acid carrier protein
IC778_14665	COG0681	Belongs to the peptidase S26 family
IC778_14700	COG4373	Mu-like prophage FluMu protein gp28
IC778_14710	COG4383	Mu-like prophage protein gp29
IC778_14735	COG4397	Mu-like prophage major head subunit gpT
IC778_14825	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IC778_14830	COG0243	molybdopterin cofactor binding
IC778_14835	COG1929	Belongs to the glycerate kinase type-1 family
IC778_14850	COG0778	Nitroreductase
IC778_14855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC778_14860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC778_14880	COG1012	belongs to the aldehyde dehydrogenase family
IC778_14885	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IC778_14890	COG0583	DNA-binding transcription factor activity
IC778_14895	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_14900	COG0596	Alpha beta hydrolase
IC778_14905	COG0596	Alpha beta hydrolase
IC778_14905	COG0508	dehydrogenase complex catalyzes the overall conversion of
IC778_14910	COG0596	Alpha beta hydrolase
IC778_14910	COG0508	dehydrogenase complex catalyzes the overall conversion of
IC778_14915	COG1902	pentaerythritol trinitrate reductase activity
IC778_14920	COG1309	transcriptional regulator
IC778_14980	COG3811	Belongs to the UPF0386 family
IC778_15000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IC778_15015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC778_15020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC778_15040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IC778_15045	COG0183	Belongs to the thiolase family
IC778_15050	COG1250	3-hydroxyacyl-CoA dehydrogenase
IC778_15055	COG1024	Enoyl-CoA hydratase
IC778_15060	COG1960	acyl-CoA dehydrogenase activity
IC778_15065	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IC778_15065	COG0644	oxidoreductase
IC778_15130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IC778_15155	COG1002	Type II restriction enzyme, methylase subunits
IC778_15160	COG1061	Type III restriction enzyme res subunit
IC778_15170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IC778_15210	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IC778_15230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IC778_15255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IC778_15275	COG0741	lytic transglycosylase activity
IC778_15295	COG0584	glycerophosphoryl diester phosphodiesterase
IC778_15300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC778_15320	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IC778_15325	COG1597	lipid kinase activity
IC778_15340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IC778_15345	COG0477	Major facilitator Superfamily
IC778_15395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IC778_15400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IC778_15425	COG0505	Belongs to the CarA family
IC778_15445	COG0589	response to stress
IC778_15465	COG2321	neutral zinc metallopeptidase
IC778_15470	COG2354	Protein conserved in bacteria
IC778_15490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IC778_15515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IC778_15520	COG1053	succinate dehydrogenase
IC778_15525	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IC778_15530	COG2009	succinate dehydrogenase
IC778_15565	COG2921	Belongs to the UPF0250 family
IC778_15570	COG0321	lipoyl(octanoyl) transferase activity
IC778_15585	COG0531	amino acid
IC778_15595	COG1733	regulation of RNA biosynthetic process
IC778_15600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IC778_15605	COG1648	precorrin-2 dehydrogenase activity
IC778_15605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IC778_15620	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IC778_15650	COG0671	phosphoesterase, PA-phosphatase related
IC778_15655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC778_15665	COG1538	Outer membrane efflux protein
IC778_15670	COG0393	Putative heavy-metal-binding
IC778_15675	COG0393	Putative heavy-metal-binding
IC778_15685	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_15695	COG0525	valine-tRNA ligase activity
IC778_15705	COG0525	valine-tRNA ligase activity
IC778_15725	COG0583	DNA-binding transcription factor activity
IC778_15730	COG0004	ammonium transporteR
IC778_15740	COG0642	Histidine kinase
IC778_15745	COG0745	RESPONSE REGULATOR receiver
IC778_15750	COG2194	sulfuric ester hydrolase activity
IC778_15770	COG1752	Esterase of the alpha-beta hydrolase superfamily
IC778_15785	COG2315	Protein conserved in bacteria
IC778_15790	COG0142	geranyltranstransferase activity
IC778_15795	COG2828	Protein conserved in bacteria
IC778_15800	COG1113	amino acid transport
IC778_15805	COG2816	NAD+ diphosphatase activity
IC778_15810	COG3046	protein related to deoxyribodipyrimidine photolyase
IC778_15840	COG2207	Transcriptional regulator
IC778_15865	COG2249	NAD(P)H dehydrogenase (quinone) activity
IC778_15885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IC778_15895	COG1530	ribonuclease E activity
IC778_15900	COG0424	maF-like protein
IC778_15905	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IC778_15910	COG1792	Involved in formation and maintenance of cell shape
IC778_15915	COG1077	Cell shape determining protein MreB Mrl
IC778_15920	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IC778_15930	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IC778_15960	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IC778_15965	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IC778_15970	COG1752	Esterase of the alpha-beta hydrolase superfamily
IC778_15975	COG1115	amino acid carrier protein
IC778_15995	COG2814	Major facilitator Superfamily
IC778_16000	COG1289	transmembrane transporter activity
IC778_16050	COG1376	ErfK ybiS ycfS ynhG family protein
IC778_16055	COG2832	Protein of unknown function (DUF454)
IC778_16080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IC778_16095	COG0840	transmembrane signaling receptor activity
IC778_16135	COG3422	double-strand break repair
IC778_16140	COG2824	Alkylphosphonate utilization operon protein PhnA
IC778_16145	COG3189	MarR family transcriptional regulator
IC778_16150	COG0596	Alpha beta hydrolase
IC778_16160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IC778_16165	COG1335	isochorismatase
IC778_16170	COG0251	oxidation-reduction process
IC778_16175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC778_16180	COG2233	PERMEase
IC778_16195	COG0354	folic acid binding
IC778_16200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IC778_16210	COG0679	Auxin Efflux Carrier
IC778_16215	COG1902	pentaerythritol trinitrate reductase activity
IC778_16220	COG4772	TonB-dependent receptor
IC778_16225	COG2094	Belongs to the DNA glycosylase MPG family
IC778_16250	COG1217	gtp-binding protein TYPA
IC778_16255	COG2233	PERMEase
IC778_16265	COG0833	amino acid
IC778_16270	COG1690	Belongs to the RtcB family
IC778_16280	COG2885	chlorophyll binding
IC778_16280	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IC778_16290	COG0183	Belongs to the thiolase family
IC778_16305	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IC778_16325	COG2207	Transcriptional regulator
IC778_16330	COG0183	Belongs to the thiolase family
IC778_16350	COG2153	protein acetylation
IC778_16360	COG1272	protein, Hemolysin III
IC778_16365	COG0477	Major facilitator Superfamily
IC778_16380	COG0450	alkyl hydroperoxide reductase
IC778_16400	COG0285	dihydrofolate synthase activity
IC778_16450	COG4206	TonB-dependent receptor
IC778_16455	COG2096	Adenosyltransferase
IC778_16475	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IC778_16485	COG0745	RESPONSE REGULATOR receiver
IC778_16490	COG2205	protein histidine kinase activity
IC778_16500	COG1960	acyl-CoA dehydrogenase activity
IC778_16505	COG1960	acyl-CoA dehydrogenase activity
IC778_16540	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IC778_16560	COG2826	transposase and inactivated derivatives, IS30 family
IC778_16585	COG0438	transferase activity, transferring glycosyl groups
IC778_16590	COG0463	Glycosyl transferase, family 2
IC778_16595	COG0726	polysaccharide deacetylase
IC778_16605	COG2194	sulfuric ester hydrolase activity
IC778_16620	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IC778_16630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IC778_16665	COG1862	Preprotein translocase
IC778_16675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IC778_16680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IC778_16690	COG3781	membrane
IC778_16695	COG0613	PHP domain protein
IC778_16705	COG2350	Protein conserved in bacteria
IC778_16740	COG1607	acyl-coa hydrolase
IC778_16765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IC778_16800	COG2199	diguanylate cyclase activity
IC778_16810	COG1408	metallophosphoesterase
IC778_16815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IC778_16825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IC778_16845	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IC778_16850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IC778_16855	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IC778_16860	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IC778_16865	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IC778_16875	COG2969	positive regulation of protein catabolic process
IC778_16910	COG1024	Enoyl-CoA hydratase
IC778_16910	COG1250	3-hydroxyacyl-CoA dehydrogenase
IC778_16915	COG1960	acyl-CoA dehydrogenase activity
IC778_16920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IC778_16935	COG1309	transcriptional regulator
IC778_16940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IC778_17005	COG1183	phosphatidylcholine synthase activity
IC778_17010	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IC778_17040	COG1196	nuclear chromosome segregation
IC778_17040	COG0741	lytic transglycosylase activity
IC778_17040	COG0739	heme binding
IC778_17050	COG1702	phosphate starvation-inducible protein PhoH
IC778_17085	COG1295	ribonuclease BN
IC778_17095	COG2169	Transcriptional regulator
IC778_17100	COG0179	Fumarylacetoacetate (FAA) hydrolase
IC778_17145	COG0557	exoribonuclease II activity
IC778_17150	COG0339	signal peptide processing
IC778_17155	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IC778_17185	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IC778_17190	COG1960	acyl-CoA dehydrogenase activity
IC778_17240	COG1841	ribosomal large subunit assembly
IC778_17325	COG0088	Forms part of the polypeptide exit tunnel
IC778_17330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IC778_17345	COG0626	cystathionine gamma-synthase activity
IC778_17350	COG0433	COG0433 Predicted ATPase
IC778_17355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC778_17355	COG1017	nitric oxide dioxygenase activity
IC778_17360	COG1959	2 iron, 2 sulfur cluster binding
IC778_17375	COG1301	dicarboxylic acid transport
IC778_17380	COG1946	Acyl-CoA thioesterase
IC778_17385	COG2937	Belongs to the GPAT DAPAT family
IC778_17400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IC778_17405	COG1040	competence protein
IC778_17410	COG0494	nUDIX hydrolase
IC778_17420	COG0598	Magnesium transport protein CorA
IC778_17430	COG2854	intermembrane phospholipid transfer
IC778_17440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IC778_17445	COG1127	ABC transporter
IC778_17450	COG0513	Belongs to the DEAD box helicase family
IC778_17470	COG0408	coproporphyrinogen oxidase activity
IC778_17485	COG1960	acyl-CoA dehydrogenase activity
IC778_17495	COG1983	PspC domain protein
IC778_17500	COG0517	IMP dehydrogenase activity
IC778_17500	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IC778_17500	COG0617	tRNA 3'-terminal CCA addition
IC778_17525	COG0752	glycyl-tRNA synthetase alpha subunit
IC778_17545	COG0583	DNA-binding transcription factor activity
IC778_17550	COG1794	racemase activity, acting on amino acids and derivatives
IC778_17555	COG0583	DNA-binding transcription factor activity
IC778_17595	COG1012	belongs to the aldehyde dehydrogenase family
IC778_17605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IC778_17610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IC778_17615	COG0833	amino acid
IC778_17620	COG2826	transposase and inactivated derivatives, IS30 family
IC778_17650	COG1192	Involved in chromosome partitioning
IC778_17655	COG0628	permease
IC778_17665	COG1289	transmembrane transporter activity
IC778_17680	COG2249	NAD(P)H dehydrogenase (quinone) activity
IC778_17685	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IC778_17695	COG0277	FAD linked oxidase domain protein
IC778_17700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IC778_17705	COG5006	permease, DMT superfamily
IC778_17725	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IC778_17730	COG5380	lipid catabolic process
IC778_17740	COG0335	large ribosomal subunit rRNA binding
IC778_17750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IC778_17765	COG4969	Belongs to the N-Me-Phe pilin family
IC778_17790	COG4969	Belongs to the N-Me-Phe pilin family
IC778_17805	COG0194	GDP metabolic process
IC778_17820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IC778_17840	COG3307	-O-antigen
IC778_17850	COG4969	Belongs to the N-Me-Phe pilin family
IC778_17860	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IC778_17865	COG1704	LemA family
IC778_17875	COG0493	'glutamate synthase
IC778_17880	COG0067	glutamate synthase
IC778_17880	COG0069	glutamate synthase activity
IC778_17880	COG0070	glutamate synthase
IC778_17930	COG2226	methyltransferase
IC778_17945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IC778_17950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IC778_17995	COG0833	amino acid
IC778_18070	COG0488	(ABC) transporter
IC778_18075	COG0028	Belongs to the TPP enzyme family
IC778_18085	COG4221	oxidoreductase activity
IC778_18090	COG0659	secondary active sulfate transmembrane transporter activity
IC778_18120	COG0427	acetyl-CoA hydrolase
IC778_18150	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IC778_18195	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IC778_18260	COG2249	NAD(P)H dehydrogenase (quinone) activity
IC778_18265	COG1733	regulation of RNA biosynthetic process
IC778_18295	COG2826	transposase and inactivated derivatives, IS30 family
IC778_18300	COG1733	regulation of RNA biosynthetic process
IC778_18320	COG0667	Aldo Keto reductase
IC778_18340	COG0583	DNA-binding transcription factor activity
IC778_18345	COG2814	Major facilitator Superfamily
IC778_18380	COG1335	isochorismatase
IC778_18390	COG1012	belongs to the aldehyde dehydrogenase family
IC778_18395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IC778_18405	COG1113	amino acid transport
IC778_18415	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IC778_18435	COG2826	transposase and inactivated derivatives, IS30 family
IC778_18475	COG2814	Major facilitator Superfamily
IC778_18485	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IC778_18485	COG0352	thiamine-phosphate diphosphorylase activity
IC778_18485	COG0351	phosphomethylpyrimidine kinase
IC778_18495	COG4221	oxidoreductase activity
IC778_18515	COG1309	transcriptional regulator
IC778_18535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IC778_18545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IC778_18550	COG3162	membrane
IC778_18555	COG2198	Histidine kinase
IC778_18555	COG0784	Response regulator, receiver
IC778_18555	COG2205	protein histidine kinase activity
IC778_18580	COG1522	sequence-specific DNA binding
IC778_18585	COG1335	isochorismatase
IC778_18590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IC778_18600	COG0668	transmembrane transport
IC778_18605	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IC778_18610	COG1519	Transferase
IC778_18615	COG1902	pentaerythritol trinitrate reductase activity
IC778_18635	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IC778_18660	COG0426	domain, Protein
IC778_18660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC778_18665	COG2119	membrane
IC778_18675	COG0508	dehydrogenase complex catalyzes the overall conversion of
IC778_18685	COG4942	peptidase
IC778_18700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IC778_18710	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IC778_18730	COG0189	ligase activity
IC778_18755	COG0708	Exodeoxyribonuclease III
IC778_18760	COG1393	Belongs to the ArsC family
IC778_18775	COG3706	GGDEF domain
IC778_18790	COG0666	response to abiotic stimulus
IC778_18790	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IC778_18810	COG2351	hydroxyisourate hydrolase activity
IC778_18825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC778_18835	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IC778_18845	COG3150	esterase
IC778_18885	COG1388	LysM domain
IC778_18885	COG1705	Flagellar rod assembly protein muramidase FlgJ
IC778_18900	COG2918	glutathione biosynthetic process
IC778_18915	COG2733	membrane
IC778_18920	COG0436	Aminotransferase
IC778_18925	COG0534	Mate efflux family protein
IC778_19020	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IC778_19025	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IC778_19035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IC778_19065	COG1280	lysine exporter protein (LysE YggA)
IC778_19070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IC778_19075	COG0546	phosphoglycolate phosphatase activity
IC778_19085	COG0010	Belongs to the arginase family
IC778_19115	COG2188	Transcriptional regulator
IC778_19125	COG0523	cobalamin synthesis protein
IC778_19135	COG1113	amino acid transport
IC778_19145	COG0625	glutathione transferase activity
IC778_19150	COG0346	lactoylglutathione lyase activity
IC778_19165	COG1683	Conserved Protein
IC778_19170	COG0534	Mate efflux family protein
IC778_19175	COG0385	Bile acid
IC778_19180	COG1335	isochorismatase
IC778_19185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IC778_19205	COG2116	formate transmembrane transporter activity
IC778_19210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IC778_19215	COG2133	pyrroloquinoline quinone binding
IC778_19220	COG2983	Belongs to the UPF0260 family
IC778_19225	COG5487	UPF0391 membrane protein
IC778_19240	COG1194	a g-specific adenine glycosylase
IC778_19255	COG2818	Glycosylase
IC778_19260	COG1064	alcohol dehydrogenase
IC778_19280	COG0583	DNA-binding transcription factor activity
IC778_19285	COG0656	L-ascorbic acid biosynthetic process
IC778_19290	COG2814	Major facilitator Superfamily
IC778_19325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC778_19340	COG2233	PERMEase
IC778_19380	COG0733	neurotransmitter:sodium symporter activity
IC778_19390	COG0625	glutathione transferase activity
IC778_19420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IC778_19425	COG0657	acetylesterase activity
IC778_19475	COG2951	lytic endotransglycosylase activity
IC778_19480	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IC778_19495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IC778_19505	COG0671	phosphoesterase, PA-phosphatase related
IC778_19510	COG0861	Integral membrane protein TerC family
IC778_19520	COG0754	glutathionylspermidine amidase activity
IC778_19530	COG0402	S-adenosylhomocysteine deaminase activity
IC778_19545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IC778_19755	COG0501	Belongs to the peptidase M48B family
IC778_19795	COG4372	Transposase
IC778_19820	COG0589	response to stress
IC778_19825	COG0659	secondary active sulfate transmembrane transporter activity
IC778_19855	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IC778_19960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IC778_20035	COG2826	transposase and inactivated derivatives, IS30 family
IC778_20045	COG2826	transposase and inactivated derivatives, IS30 family
IC778_20145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IC778_20195	COG1192	Involved in chromosome partitioning
IC778_20210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IC778_20255	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IC778_20285	COG0477	Major facilitator Superfamily
IC778_20290	COG0697	spore germination
IC778_20300	COG3321	synthase
IC778_20300	COG0604	alcohol dehydrogenase
IC778_20305	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IC778_20310	COG0583	DNA-binding transcription factor activity
IC778_20315	COG3328	transposase activity
IC778_20330	COG0659	secondary active sulfate transmembrane transporter activity
IC778_20335	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
IC778_20370	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
IC778_20520	COG0789	Transcriptional regulator
IC778_20560	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC778_20585	COG2132	Multicopper oxidase
IC778_20600	COG2205	protein histidine kinase activity
IC778_20610	COG2217	Heavy metal translocating P-type atpase
IC778_20700	COG0210	DNA helicase
IC778_20720	COG0210	DNA helicase
IC778_20765	COG0582	viral genome integration into host DNA
IC778_20780	COG2130	NADP-dependent
IC778_20785	COG1309	transcriptional regulator
IC778_20795	COG1902	pentaerythritol trinitrate reductase activity
IC778_20885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IC778_20920	COG0741	lytic transglycosylase activity
IC778_21100	COG3853	Toxic anion resistance protein (TelA)
IC778_21115	COG1475	DNA binding
IC778_21195	COG1525	nuclease