locus-tag	class	description
I8T81_00010	COG0592	DNA-directed DNA polymerase activity
I8T81_00020	COG0187	DNA topoisomerase II activity
I8T81_00030	COG0586	Pfam SNARE associated Golgi protein
I8T81_00035	COG0488	(ABC) transporter
I8T81_00060	COG0596	Alpha beta hydrolase
I8T81_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I8T81_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I8T81_00100	COG0625	glutathione transferase activity
I8T81_00110	COG0733	neurotransmitter:sodium symporter activity
I8T81_00150	COG2233	PERMEase
I8T81_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I8T81_00200	COG2814	Major facilitator Superfamily
I8T81_00205	COG0656	L-ascorbic acid biosynthetic process
I8T81_00210	COG0583	DNA-binding transcription factor activity
I8T81_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8T81_00230	COG1064	alcohol dehydrogenase
I8T81_00235	COG2818	Glycosylase
I8T81_00250	COG1194	a g-specific adenine glycosylase
I8T81_00265	COG5487	UPF0391 membrane protein
I8T81_00270	COG2983	Belongs to the UPF0260 family
I8T81_00275	COG2133	pyrroloquinoline quinone binding
I8T81_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I8T81_00285	COG2116	formate transmembrane transporter activity
I8T81_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I8T81_00310	COG1335	isochorismatase
I8T81_00315	COG0385	Bile acid
I8T81_00320	COG0534	Mate efflux family protein
I8T81_00325	COG1683	Conserved Protein
I8T81_00340	COG0346	lactoylglutathione lyase activity
I8T81_00345	COG0625	glutathione transferase activity
I8T81_00355	COG1113	amino acid transport
I8T81_00365	COG0523	cobalamin synthesis protein
I8T81_00375	COG2188	Transcriptional regulator
I8T81_00405	COG0010	Belongs to the arginase family
I8T81_00415	COG0546	phosphoglycolate phosphatase activity
I8T81_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I8T81_00440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I8T81_00450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I8T81_00455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I8T81_00550	COG0534	Mate efflux family protein
I8T81_00555	COG0436	Aminotransferase
I8T81_00560	COG2733	membrane
I8T81_00575	COG2918	glutathione biosynthetic process
I8T81_00630	COG3150	esterase
I8T81_00675	COG1335	isochorismatase
I8T81_00685	COG1902	pentaerythritol trinitrate reductase activity
I8T81_00690	COG0583	DNA-binding transcription factor activity
I8T81_00700	COG1902	pentaerythritol trinitrate reductase activity
I8T81_00715	COG0464	growth
I8T81_00725	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I8T81_00735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8T81_00745	COG2233	PERMEase
I8T81_00750	COG2351	hydroxyisourate hydrolase activity
I8T81_00785	COG3706	GGDEF domain
I8T81_00800	COG1393	Belongs to the ArsC family
I8T81_00805	COG0708	Exodeoxyribonuclease III
I8T81_00830	COG0189	ligase activity
I8T81_00850	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I8T81_00860	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I8T81_00875	COG4942	peptidase
I8T81_00885	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8T81_00895	COG2119	membrane
I8T81_00900	COG0426	domain, Protein
I8T81_00900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I8T81_00925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I8T81_00945	COG1902	pentaerythritol trinitrate reductase activity
I8T81_00950	COG1519	Transferase
I8T81_00955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I8T81_00960	COG0668	transmembrane transport
I8T81_00970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I8T81_00975	COG1335	isochorismatase
I8T81_00980	COG1522	sequence-specific DNA binding
I8T81_01005	COG2205	protein histidine kinase activity
I8T81_01005	COG2198	Histidine kinase
I8T81_01005	COG0784	Response regulator, receiver
I8T81_01010	COG3162	membrane
I8T81_01015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8T81_01025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I8T81_01045	COG1309	transcriptional regulator
I8T81_01065	COG4221	oxidoreductase activity
I8T81_01075	COG0351	phosphomethylpyrimidine kinase
I8T81_01075	COG0352	thiamine-phosphate diphosphorylase activity
I8T81_01075	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I8T81_01085	COG2814	Major facilitator Superfamily
I8T81_01145	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I8T81_01155	COG1113	amino acid transport
I8T81_01165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I8T81_01170	COG1012	belongs to the aldehyde dehydrogenase family
I8T81_01180	COG1335	isochorismatase
I8T81_01215	COG2814	Major facilitator Superfamily
I8T81_01220	COG0583	DNA-binding transcription factor activity
I8T81_01245	COG0667	Aldo Keto reductase
I8T81_01290	COG1733	regulation of RNA biosynthetic process
I8T81_01305	COG1733	regulation of RNA biosynthetic process
I8T81_01310	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8T81_01380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I8T81_01395	COG2329	Antibiotic biosynthesis monooxygenase
I8T81_01410	COG1132	(ABC) transporter
I8T81_01430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I8T81_01460	COG0427	acetyl-CoA hydrolase
I8T81_01490	COG0659	secondary active sulfate transmembrane transporter activity
I8T81_01495	COG4221	oxidoreductase activity
I8T81_01505	COG0028	Belongs to the TPP enzyme family
I8T81_01510	COG0488	(ABC) transporter
I8T81_01585	COG0833	amino acid
I8T81_01630	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I8T81_01635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I8T81_01650	COG2226	methyltransferase
I8T81_01700	COG0067	glutamate synthase
I8T81_01700	COG0069	glutamate synthase activity
I8T81_01700	COG0070	glutamate synthase
I8T81_01705	COG0493	'glutamate synthase
I8T81_01715	COG1704	LemA family
I8T81_01720	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I8T81_01730	COG4969	Belongs to the N-Me-Phe pilin family
I8T81_01735	COG3307	-O-antigen
I8T81_01740	COG3307	-O-antigen
I8T81_01760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I8T81_01775	COG0194	GDP metabolic process
I8T81_01810	COG4969	Belongs to the N-Me-Phe pilin family
I8T81_01825	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I8T81_01835	COG0335	large ribosomal subunit rRNA binding
I8T81_01845	COG5380	lipid catabolic process
I8T81_01850	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I8T81_01875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I8T81_01880	COG0277	FAD linked oxidase domain protein
I8T81_01890	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I8T81_01895	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8T81_01910	COG1289	transmembrane transporter activity
I8T81_01920	COG0628	permease
I8T81_01925	COG1192	Involved in chromosome partitioning
I8T81_01955	COG0833	amino acid
I8T81_01960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I8T81_01965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8T81_01975	COG1012	belongs to the aldehyde dehydrogenase family
I8T81_02015	COG0583	DNA-binding transcription factor activity
I8T81_02020	COG1794	racemase activity, acting on amino acids and derivatives
I8T81_02025	COG0583	DNA-binding transcription factor activity
I8T81_02045	COG0752	glycyl-tRNA synthetase alpha subunit
I8T81_02070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I8T81_02070	COG0517	IMP dehydrogenase activity
I8T81_02070	COG0617	tRNA 3'-terminal CCA addition
I8T81_02075	COG1983	PspC domain protein
I8T81_02085	COG1960	acyl-CoA dehydrogenase activity
I8T81_02100	COG0408	coproporphyrinogen oxidase activity
I8T81_02120	COG0513	Belongs to the DEAD box helicase family
I8T81_02125	COG1127	ABC transporter
I8T81_02130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I8T81_02140	COG2854	intermembrane phospholipid transfer
I8T81_02150	COG0598	Magnesium transport protein CorA
I8T81_02160	COG0494	nUDIX hydrolase
I8T81_02165	COG1040	competence protein
I8T81_02170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I8T81_02185	COG2937	Belongs to the GPAT DAPAT family
I8T81_02190	COG1946	Acyl-CoA thioesterase
I8T81_02195	COG1301	dicarboxylic acid transport
I8T81_02210	COG1959	2 iron, 2 sulfur cluster binding
I8T81_02215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I8T81_02215	COG1017	nitric oxide dioxygenase activity
I8T81_02220	COG0433	COG0433 Predicted ATPase
I8T81_02225	COG0626	cystathionine gamma-synthase activity
I8T81_02240	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I8T81_02245	COG0088	Forms part of the polypeptide exit tunnel
I8T81_02380	COG1960	acyl-CoA dehydrogenase activity
I8T81_02385	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I8T81_02415	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I8T81_02420	COG0339	signal peptide processing
I8T81_02425	COG0557	exoribonuclease II activity
I8T81_02470	COG0179	Fumarylacetoacetate (FAA) hydrolase
I8T81_02475	COG2169	Transcriptional regulator
I8T81_02485	COG1295	ribonuclease BN
I8T81_02520	COG1702	phosphate starvation-inducible protein PhoH
I8T81_02530	COG0739	heme binding
I8T81_02530	COG1196	nuclear chromosome segregation
I8T81_02530	COG0741	lytic transglycosylase activity
I8T81_02560	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I8T81_02565	COG1183	phosphatidylcholine synthase activity
I8T81_02615	COG1960	acyl-CoA dehydrogenase activity
I8T81_02620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8T81_02625	COG1309	transcriptional regulator
I8T81_02645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8T81_02650	COG1960	acyl-CoA dehydrogenase activity
I8T81_02690	COG2969	positive regulation of protein catabolic process
I8T81_02700	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I8T81_02705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I8T81_02710	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I8T81_02715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I8T81_02720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I8T81_02740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I8T81_02750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8T81_02755	COG1408	metallophosphoesterase
I8T81_02765	COG2199	diguanylate cyclase activity
I8T81_02825	COG1607	acyl-coa hydrolase
I8T81_02860	COG2350	Protein conserved in bacteria
I8T81_02870	COG0613	PHP domain protein
I8T81_02875	COG3781	membrane
I8T81_02885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I8T81_02890	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I8T81_02900	COG1862	Preprotein translocase
I8T81_02955	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I8T81_02970	COG2194	sulfuric ester hydrolase activity
I8T81_02980	COG0726	polysaccharide deacetylase
I8T81_02985	COG0463	Glycosyl transferase, family 2
I8T81_02990	COG0438	transferase activity, transferring glycosyl groups
I8T81_03065	COG1960	acyl-CoA dehydrogenase activity
I8T81_03070	COG1960	acyl-CoA dehydrogenase activity
I8T81_03080	COG2205	protein histidine kinase activity
I8T81_03085	COG0745	RESPONSE REGULATOR receiver
I8T81_03095	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I8T81_03115	COG2096	Adenosyltransferase
I8T81_03170	COG0285	dihydrofolate synthase activity
I8T81_03190	COG0450	alkyl hydroperoxide reductase
I8T81_03205	COG0477	Major facilitator Superfamily
I8T81_03210	COG1272	protein, Hemolysin III
I8T81_03220	COG2153	protein acetylation
I8T81_03240	COG0183	Belongs to the thiolase family
I8T81_03245	COG2207	Transcriptional regulator
I8T81_03265	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I8T81_03280	COG0183	Belongs to the thiolase family
I8T81_03290	COG2885	chlorophyll binding
I8T81_03290	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I8T81_03300	COG1690	Belongs to the RtcB family
I8T81_03305	COG0833	amino acid
I8T81_03315	COG2233	PERMEase
I8T81_03320	COG1217	gtp-binding protein TYPA
I8T81_03350	COG2094	Belongs to the DNA glycosylase MPG family
I8T81_03355	COG4772	TonB-dependent receptor
I8T81_03360	COG1902	pentaerythritol trinitrate reductase activity
I8T81_03365	COG0679	Auxin Efflux Carrier
I8T81_03375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I8T81_03380	COG0354	folic acid binding
I8T81_03390	COG3189	MarR family transcriptional regulator
I8T81_03395	COG2824	Alkylphosphonate utilization operon protein PhnA
I8T81_03400	COG3422	double-strand break repair
I8T81_03440	COG0840	transmembrane signaling receptor activity
I8T81_03455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I8T81_03480	COG2832	Protein of unknown function (DUF454)
I8T81_03485	COG1376	ErfK ybiS ycfS ynhG family protein
I8T81_03535	COG1289	transmembrane transporter activity
I8T81_03540	COG2814	Major facilitator Superfamily
I8T81_03560	COG1115	amino acid carrier protein
I8T81_03565	COG1752	Esterase of the alpha-beta hydrolase superfamily
I8T81_03570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I8T81_03575	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I8T81_03605	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I8T81_03615	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I8T81_03620	COG1077	Cell shape determining protein MreB Mrl
I8T81_03625	COG1792	Involved in formation and maintenance of cell shape
I8T81_03630	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I8T81_03635	COG0424	maF-like protein
I8T81_03640	COG1530	ribonuclease E activity
I8T81_03650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8T81_03670	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8T81_03695	COG2207	Transcriptional regulator
I8T81_03740	COG3046	protein related to deoxyribodipyrimidine photolyase
I8T81_03745	COG2816	NAD+ diphosphatase activity
I8T81_03750	COG1113	amino acid transport
I8T81_03755	COG2828	Protein conserved in bacteria
I8T81_03760	COG0142	geranyltranstransferase activity
I8T81_03765	COG2315	Protein conserved in bacteria
I8T81_03780	COG1752	Esterase of the alpha-beta hydrolase superfamily
I8T81_03800	COG2194	sulfuric ester hydrolase activity
I8T81_03805	COG0745	RESPONSE REGULATOR receiver
I8T81_03810	COG0642	Histidine kinase
I8T81_03820	COG0004	ammonium transporteR
I8T81_03825	COG0583	DNA-binding transcription factor activity
I8T81_03845	COG0525	valine-tRNA ligase activity
I8T81_03855	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_03865	COG0393	Putative heavy-metal-binding
I8T81_03870	COG0393	Putative heavy-metal-binding
I8T81_03875	COG1538	Outer membrane efflux protein
I8T81_03885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I8T81_03890	COG0671	phosphoesterase, PA-phosphatase related
I8T81_03920	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I8T81_03935	COG1648	precorrin-2 dehydrogenase activity
I8T81_03935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I8T81_03940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I8T81_03955	COG0531	amino acid
I8T81_03970	COG0321	lipoyl(octanoyl) transferase activity
I8T81_03975	COG2921	Belongs to the UPF0250 family
I8T81_04010	COG2009	succinate dehydrogenase
I8T81_04015	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I8T81_04020	COG1053	succinate dehydrogenase
I8T81_04025	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I8T81_04050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8T81_04070	COG2354	Protein conserved in bacteria
I8T81_04075	COG2321	neutral zinc metallopeptidase
I8T81_04095	COG2843	Capsule synthesis protein
I8T81_04115	COG0589	response to stress
I8T81_04135	COG0505	Belongs to the CarA family
I8T81_04160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I8T81_04165	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I8T81_04215	COG0477	Major facilitator Superfamily
I8T81_04220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I8T81_04235	COG1597	lipid kinase activity
I8T81_04240	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I8T81_04260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8T81_04265	COG0584	glycerophosphoryl diester phosphodiesterase
I8T81_04285	COG0741	lytic transglycosylase activity
I8T81_04305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8T81_04310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I8T81_04325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I8T81_04345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8T81_04395	COG3811	Belongs to the UPF0386 family
I8T81_04440	COG1309	transcriptional regulator
I8T81_04445	COG1902	pentaerythritol trinitrate reductase activity
I8T81_04450	COG0596	Alpha beta hydrolase
I8T81_04450	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8T81_04455	COG0596	Alpha beta hydrolase
I8T81_04455	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8T81_04460	COG0596	Alpha beta hydrolase
I8T81_04470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I8T81_04475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I8T81_04480	COG0778	Nitroreductase
I8T81_04495	COG1929	Belongs to the glycerate kinase type-1 family
I8T81_04500	COG0243	molybdopterin cofactor binding
I8T81_04505	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I8T81_04535	COG1115	amino acid carrier protein
I8T81_04540	COG1113	amino acid transport
I8T81_04550	COG0019	diaminopimelate decarboxylase activity
I8T81_04560	COG1280	lysine exporter protein (LysE YggA)
I8T81_04565	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I8T81_04585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8T81_04595	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I8T81_04605	COG0463	Glycosyl transferase, family 2
I8T81_04625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I8T81_04655	COG4591	ABC-type transport system involved in lipoprotein release permease component
I8T81_04660	COG1136	(ABC) transporter
I8T81_04665	COG2333	competence protein COMEC
I8T81_04665	COG0658	competence protein
I8T81_04675	COG0616	signal peptide processing
I8T81_04675	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I8T81_04680	COG0596	Alpha beta hydrolase
I8T81_04685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I8T81_04695	COG0628	permease
I8T81_04730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I8T81_04750	COG0823	Involved in the tonB-independent uptake of proteins
I8T81_04770	COG0824	Thioesterase
I8T81_04775	COG1473	amidohydrolase
I8T81_04800	COG0047	phosphoribosylformylglycinamidine synthase activity
I8T81_04800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I8T81_04805	COG2814	Major facilitator Superfamily
I8T81_04825	COG1024	Enoyl-CoA hydratase
I8T81_04830	COG1051	belongs to the nudix hydrolase family
I8T81_04830	COG1056	cytidyltransferase-related domain
I8T81_04845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I8T81_04860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I8T81_04865	COG0602	queuosine metabolic process
I8T81_04875	COG4625	pathogenesis
I8T81_04880	COG0583	DNA-binding transcription factor activity
I8T81_04885	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I8T81_04890	COG4208	sulfate ABC transporter
I8T81_04895	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I8T81_04905	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I8T81_04910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8T81_04915	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I8T81_04935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8T81_04945	COG0481	GTPase activity
I8T81_04950	COG0681	Belongs to the peptidase S26 family
I8T81_04965	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I8T81_04975	COG1381	Involved in DNA repair and RecF pathway recombination
I8T81_04980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I8T81_04990	COG4221	oxidoreductase activity
I8T81_05015	COG0436	Aminotransferase
I8T81_05050	COG0556	nucleotide-excision repair
I8T81_05105	COG2070	2-Nitropropane dioxygenase
I8T81_05135	COG1215	transferase activity, transferring glycosyl groups
I8T81_05160	COG1252	NADH dehydrogenase
I8T81_05165	COG1686	Belongs to the peptidase S11 family
I8T81_05180	COG1187	pseudouridine synthase activity
I8T81_05200	COG0477	Major facilitator Superfamily
I8T81_05205	COG0583	DNA-binding transcription factor activity
I8T81_05210	COG1823	symporter activity
I8T81_05220	COG0612	Peptidase, M16
I8T81_05245	COG0352	thiamine-phosphate diphosphorylase activity
I8T81_05280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I8T81_05305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I8T81_05310	COG0076	glutamate decarboxylase activity
I8T81_05320	COG1522	sequence-specific DNA binding
I8T81_05325	COG3961	Belongs to the TPP enzyme family
I8T81_05330	COG1113	amino acid transport
I8T81_05335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I8T81_05340	COG0573	inorganic phosphate transmembrane transporter activity
I8T81_05350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I8T81_05355	COG0616	signal peptide processing
I8T81_05370	COG3647	Membrane
I8T81_05395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I8T81_05400	COG1686	Belongs to the peptidase S11 family
I8T81_05425	COG0583	DNA-binding transcription factor activity
I8T81_05430	COG1067	ATP-dependent peptidase activity
I8T81_05455	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I8T81_05470	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I8T81_05475	COG1966	Carbon starvation protein
I8T81_05480	COG2879	small protein
I8T81_05540	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I8T81_05545	COG2423	ornithine cyclodeaminase activity
I8T81_05555	COG2964	Protein conserved in bacteria
I8T81_05565	COG1741	Belongs to the pirin family
I8T81_05580	COG3739	integral membrane protein
I8T81_05600	COG0302	gtp cyclohydrolase
I8T81_05610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I8T81_05620	COG2840	Smr protein MutS2
I8T81_05635	COG0512	Glutamine amidotransferase of anthranilate synthase
I8T81_05650	COG0174	glutamine synthetase
I8T81_05660	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I8T81_05695	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I8T81_05700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I8T81_05705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8T81_05725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I8T81_05730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I8T81_05735	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I8T81_05750	COG1960	acyl-CoA dehydrogenase activity
I8T81_05755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I8T81_05760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8T81_05770	COG2223	nitrite transmembrane transporter activity
I8T81_05780	COG0024	Methionine aminopeptidase
I8T81_05785	COG0052	Belongs to the universal ribosomal protein uS2 family
I8T81_05800	COG2207	Transcriptional regulator
I8T81_05825	COG2951	lytic endotransglycosylase activity
I8T81_05830	COG0772	Belongs to the SEDS family
I8T81_05845	COG0842	Transport permease protein
I8T81_05850	COG1131	(ABC) transporter
I8T81_06020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I8T81_06035	COG4215	(ABC) transporter
I8T81_06040	COG4160	amino acid transport
I8T81_06045	COG4598	ABC transporter
I8T81_06055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I8T81_06060	COG0826	peptidase U32
I8T81_06065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8T81_06080	COG1720	tRNA m6t6A37 methyltransferase activity
I8T81_06090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I8T81_06105	COG0642	Histidine kinase
I8T81_06115	COG0494	nUDIX hydrolase
I8T81_06125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8T81_06130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I8T81_06135	COG3139	Protein of unknown function (DUF1315)
I8T81_06145	COG1301	dicarboxylic acid transport
I8T81_06150	COG1960	acyl-CoA dehydrogenase activity
I8T81_06170	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I8T81_06180	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I8T81_06185	COG2195	Cleaves the N-terminal amino acid of tripeptides
I8T81_06205	COG1690	Belongs to the RtcB family
I8T81_06210	COG1234	tRNA 3'-trailer cleavage
I8T81_06215	COG4650	regulator
I8T81_06245	COG2363	Small membrane protein
I8T81_06265	COG0513	Belongs to the DEAD box helicase family
I8T81_06275	COG0778	Nitroreductase
I8T81_06335	COG1610	YqeY-like protein
I8T81_06365	COG0515	serine threonine protein kinase
I8T81_06365	COG2815	serine threonine protein kinase
I8T81_06465	COG0786	glutamate:sodium symporter activity
I8T81_06470	COG0475	glutathione-regulated potassium exporter activity
I8T81_06470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I8T81_06475	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_06550	COG1309	transcriptional regulator
I8T81_06560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I8T81_06560	COG2169	Transcriptional regulator
I8T81_06575	COG2985	domain, Protein
I8T81_06600	COG2995	paraquat-inducible protein a
I8T81_06605	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I8T81_06605	COG3008	intermembrane lipid transfer
I8T81_06615	COG2351	hydroxyisourate hydrolase activity
I8T81_06630	COG5002	protein histidine kinase activity
I8T81_06655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I8T81_06665	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I8T81_06670	COG0642	Histidine kinase
I8T81_06675	COG0745	RESPONSE REGULATOR receiver
I8T81_06700	COG2175	clavaminate synthase activity
I8T81_06705	COG3246	L-lysine catabolic process to acetate
I8T81_06710	COG2814	Major facilitator Superfamily
I8T81_06725	COG2855	membrane
I8T81_06770	COG1301	dicarboxylic acid transport
I8T81_06785	COG2011	ABC-type metal ion transport system permease component
I8T81_06790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I8T81_06795	COG1464	Belongs to the NlpA lipoprotein family
I8T81_06800	COG0151	Belongs to the GarS family
I8T81_06805	COG0138	bifunctional purine biosynthesis protein purh
I8T81_06810	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I8T81_06840	COG2308	Evidence 4 Homologs of previously reported genes of
I8T81_06850	COG1305	Transglutaminase-like
I8T81_06860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I8T81_06865	COG0305	Participates in initiation and elongation during chromosome replication
I8T81_06890	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I8T81_06900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I8T81_06930	COG0726	polysaccharide deacetylase
I8T81_06930	COG1649	PFAM Uncharacterised BCR, COG1649
I8T81_06935	COG1215	transferase activity, transferring glycosyl groups
I8T81_06940	COG3658	cytochrome
I8T81_06950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8T81_06975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I8T81_06980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I8T81_06995	COG1960	acyl-CoA dehydrogenase activity
I8T81_07000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I8T81_07005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I8T81_07030	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I8T81_07035	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I8T81_07040	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I8T81_07045	COG2205	protein histidine kinase activity
I8T81_07050	COG0745	RESPONSE REGULATOR receiver
I8T81_07055	COG0174	glutamine synthetase
I8T81_07075	COG0729	surface antigen
I8T81_07105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I8T81_07110	COG2814	Major facilitator Superfamily
I8T81_07120	COG0583	DNA-binding transcription factor activity
I8T81_07135	COG1187	pseudouridine synthase activity
I8T81_07155	COG0802	atpase or kinase
I8T81_07160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I8T81_07170	COG1923	regulation of RNA biosynthetic process
I8T81_07175	COG0697	spore germination
I8T81_07190	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I8T81_07200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I8T81_07205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I8T81_07205	COG0519	Catalyzes the synthesis of GMP from XMP
I8T81_07210	COG4302	ethanolamine ammonia-lyase activity
I8T81_07215	COG4303	Ethanolamine ammonia lyase large subunit
I8T81_07220	COG0531	amino acid
I8T81_07240	COG1454	alcohol dehydrogenase
I8T81_07245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I8T81_07255	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I8T81_07275	COG0308	aminopeptidase N
I8T81_07305	COG0625	glutathione transferase activity
I8T81_07320	COG1605	Chorismate mutase
I8T81_07350	COG4264	IucA IucC family
I8T81_07360	COG4264	IucA IucC family
I8T81_07365	COG2423	ornithine cyclodeaminase activity
I8T81_07370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8T81_07380	COG0668	transmembrane transport
I8T81_07425	COG0488	(ABC) transporter
I8T81_07430	COG0589	response to stress
I8T81_07455	COG3135	benzoate transporter
I8T81_07460	COG1522	sequence-specific DNA binding
I8T81_07470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I8T81_07475	COG0583	DNA-binding transcription factor activity
I8T81_07485	COG0183	Belongs to the thiolase family
I8T81_07490	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_07495	COG2030	dehydratase
I8T81_07500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8T81_07525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I8T81_07535	COG0824	Thioesterase
I8T81_07540	COG1454	alcohol dehydrogenase
I8T81_07565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I8T81_07595	COG0069	glutamate synthase activity
I8T81_07635	COG2814	Major facilitator Superfamily
I8T81_07650	COG0511	ligase activity, forming carbon-carbon bonds
I8T81_07665	COG1116	anion transmembrane transporter activity
I8T81_07665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I8T81_07670	COG0745	RESPONSE REGULATOR receiver
I8T81_07680	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I8T81_07680	COG2146	nitrite reductase [NAD(P)H] activity
I8T81_07685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I8T81_07690	COG0243	molybdopterin cofactor binding
I8T81_07700	COG0243	molybdopterin cofactor binding
I8T81_07705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I8T81_07720	COG0521	Mo-molybdopterin cofactor biosynthetic process
I8T81_07720	COG0315	cyclic pyranopterin monophosphate synthase activity
I8T81_07725	COG0303	'Molybdopterin
I8T81_07735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8T81_07740	COG0697	spore germination
I8T81_07760	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I8T81_07765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I8T81_07820	COG2204	response regulator
I8T81_07825	COG3852	Histidine kinase
I8T81_07845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I8T81_07850	COG0575	Belongs to the CDS family
I8T81_07885	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I8T81_07900	COG2137	regulation of response to DNA damage stimulus
I8T81_07910	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I8T81_07915	COG1011	Hydrolase
I8T81_07930	COG1522	sequence-specific DNA binding
I8T81_07940	COG1113	amino acid transport
I8T81_07955	COG0659	secondary active sulfate transmembrane transporter activity
I8T81_07970	COG5001	Diguanylate cyclase
I8T81_07970	COG3300	MHYT domain
I8T81_07990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8T81_07990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8T81_07990	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I8T81_07995	COG1105	Belongs to the carbohydrate kinase PfkB family
I8T81_08000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I8T81_08000	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8T81_08030	COG0024	Methionine aminopeptidase
I8T81_08035	COG0583	DNA-binding transcription factor activity
I8T81_08045	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I8T81_08050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8T81_08055	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I8T81_08080	COG0552	protein localization to endoplasmic reticulum
I8T81_08090	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I8T81_08105	COG4890	Cyd operon protein YbgT
I8T81_08110	COG1294	oxidase, subunit
I8T81_08125	COG1585	Membrane protein implicated in regulation of membrane protease activity
I8T81_08135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8T81_08140	COG4774	siderophore transport
I8T81_08155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I8T81_08160	COG0569	domain protein
I8T81_08165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I8T81_08195	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I8T81_08200	COG0542	response to heat
I8T81_08225	COG0446	pyridine nucleotide-disulphide oxidoreductase
I8T81_08225	COG1902	pentaerythritol trinitrate reductase activity
I8T81_08265	COG0148	phosphopyruvate hydratase activity
I8T81_08270	COG2323	membrane
I8T81_08280	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I8T81_08290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I8T81_08295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I8T81_08300	COG0183	Belongs to the thiolase family
I8T81_08305	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I8T81_08310	COG0596	Alpha beta hydrolase
I8T81_08315	COG2271	Major facilitator Superfamily
I8T81_08320	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8T81_08325	COG3485	protocatechuate 3,4-dioxygenase
I8T81_08330	COG3485	protocatechuate 3,4-dioxygenase
I8T81_08335	COG0710	3-dehydroquinate dehydratase activity
I8T81_08340	COG3420	alginic acid biosynthetic process
I8T81_08345	COG3659	wide pore channel activity
I8T81_08350	COG4993	Dehydrogenase
I8T81_08360	COG2391	methyltransferase activity
I8T81_08455	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_08460	COG0477	Major facilitator Superfamily
I8T81_08465	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_08470	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_08475	COG4221	oxidoreductase activity
I8T81_08480	COG4753	response regulator
I8T81_08480	COG2207	Transcriptional regulator
I8T81_08495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I8T81_08500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8T81_08505	COG1012	belongs to the aldehyde dehydrogenase family
I8T81_08510	COG3938	Belongs to the proline racemase family
I8T81_08520	COG1115	amino acid carrier protein
I8T81_08530	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I8T81_08550	COG0583	DNA-binding transcription factor activity
I8T81_08555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8T81_08560	COG0251	oxidation-reduction process
I8T81_08565	COG0814	amino acid
I8T81_08570	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I8T81_08580	COG2814	Major facilitator Superfamily
I8T81_08610	COG0251	oxidation-reduction process
I8T81_08615	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I8T81_08620	COG1473	amidohydrolase
I8T81_08625	COG0814	amino acid
I8T81_08630	COG1522	sequence-specific DNA binding
I8T81_08645	COG1414	Transcriptional regulator
I8T81_08650	COG0583	DNA-binding transcription factor activity
I8T81_08655	COG1960	acyl-CoA dehydrogenase activity
I8T81_08680	COG2814	Major facilitator Superfamily
I8T81_08690	COG0154	amidase activity
I8T81_08710	COG4638	Rieske (2fe-2S)
I8T81_08720	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_08730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I8T81_08740	COG3733	amine oxidase
I8T81_08750	COG1012	belongs to the aldehyde dehydrogenase family
I8T81_08755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I8T81_08760	COG0183	Belongs to the thiolase family
I8T81_08765	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I8T81_08770	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I8T81_08780	COG4829	muconolactone delta-isomerase
I8T81_08785	COG4948	Mandelate Racemase Muconate Lactonizing
I8T81_08790	COG0583	DNA-binding transcription factor activity
I8T81_08810	COG1902	pentaerythritol trinitrate reductase activity
I8T81_08810	COG0446	pyridine nucleotide-disulphide oxidoreductase
I8T81_08820	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I8T81_08855	COG1309	transcriptional regulator
I8T81_08870	COG4774	siderophore transport
I8T81_08885	COG4689	acetoacetate decarboxylase
I8T81_08895	COG1902	pentaerythritol trinitrate reductase activity
I8T81_08905	COG2831	hemolysin activation secretion protein
I8T81_08910	COG3210	domain, Protein
I8T81_08945	COG2188	Transcriptional regulator
I8T81_08950	COG0583	DNA-binding transcription factor activity
I8T81_08975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I8T81_08980	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I8T81_09000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8T81_09015	COG2271	Major facilitator Superfamily
I8T81_09055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8T81_09060	COG1120	ATPase activity
I8T81_09080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I8T81_09160	COG2431	L-lysine efflux transmembrane transporter activity
I8T81_09170	COG1073	alpha beta
I8T81_09185	COG4628	conserved protein (DUF2132)
I8T81_09220	COG3971	2-oxopent-4-enoate hydratase activity
I8T81_09225	COG4569	acetaldehyde dehydrogenase (acetylating) activity
I8T81_09230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I8T81_09260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8T81_09270	COG1454	alcohol dehydrogenase
I8T81_09295	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I8T81_09300	COG4221	oxidoreductase activity
I8T81_09310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8T81_09330	COG0028	Belongs to the TPP enzyme family
I8T81_09345	COG1301	dicarboxylic acid transport
I8T81_09355	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_09380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I8T81_09385	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I8T81_09390	COG0183	Belongs to the thiolase family
I8T81_09395	COG4829	muconolactone delta-isomerase
I8T81_09400	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I8T81_09400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8T81_09430	COG2161	toxin-antitoxin pair type II binding
I8T81_09465	COG2175	clavaminate synthase activity
I8T81_09470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I8T81_09485	COG0667	Aldo Keto reductase
I8T81_09490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8T81_09505	COG2175	clavaminate synthase activity
I8T81_09535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I8T81_09540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8T81_09545	COG4771	TonB-dependent receptor
I8T81_09575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8T81_09580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I8T81_09585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I8T81_09590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I8T81_09605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I8T81_09610	COG0805	protein transport
I8T81_09620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8T81_09640	COG1132	(ABC) transporter
I8T81_09645	COG1132	(ABC) transporter
I8T81_09665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8T81_09670	COG0601	transmembrane transport
I8T81_09700	COG3539	Fimbrial protein
I8T81_09725	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I8T81_09735	COG0753	catalase activity
I8T81_09745	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I8T81_09750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8T81_09760	COG2205	protein histidine kinase activity
I8T81_09765	COG0745	RESPONSE REGULATOR receiver
I8T81_09770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I8T81_09775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I8T81_09835	COG4771	TonB-dependent receptor
I8T81_09845	COG1535	isochorismatase
I8T81_09845	COG3433	isochorismatase activity
I8T81_09850	COG1021	2,3-dihydroxybenzoate-AMP ligase
I8T81_09855	COG1169	isochorismate synthase
I8T81_09860	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_09870	COG3251	PFAM MbtH domain protein
I8T81_09875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8T81_09900	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I8T81_09905	COG4149	molybdate abc transporter
I8T81_09910	COG0725	ABC transporter, periplasmic molybdate-binding protein
I8T81_09920	COG4638	Rieske (2fe-2S)
I8T81_09925	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I8T81_09930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I8T81_09930	COG0543	2 iron, 2 sulfur cluster binding
I8T81_09945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I8T81_09955	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_09975	COG2207	Transcriptional regulator
I8T81_09980	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_09985	COG2610	gluconate transmembrane transporter activity
I8T81_09990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8T81_10020	COG2814	Major facilitator Superfamily
I8T81_10035	COG0583	DNA-binding transcription factor activity
I8T81_10050	COG2031	fatty acid transporter
I8T81_10055	COG0183	Belongs to the thiolase family
I8T81_10060	COG0583	DNA-binding transcription factor activity
I8T81_10065	COG0583	DNA-binding transcription factor activity
I8T81_10080	COG1027	Aspartate ammonia-lyase
I8T81_10090	COG0477	Major facilitator Superfamily
I8T81_10100	COG1609	Transcriptional regulator
I8T81_10100	COG2207	Transcriptional regulator
I8T81_10115	COG0730	response to heat
I8T81_10135	COG3781	membrane
I8T81_10140	COG1063	alcohol dehydrogenase
I8T81_10150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8T81_10155	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8T81_10160	COG0022	dehydrogenase e1 component
I8T81_10165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I8T81_10170	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I8T81_10185	COG3706	GGDEF domain
I8T81_10200	COG0133	tryptophan synthase activity
I8T81_10210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I8T81_10245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I8T81_10270	COG2226	methyltransferase
I8T81_10320	COG0842	Transport permease protein
I8T81_10325	COG0842	Transport permease protein
I8T81_10330	COG1131	(ABC) transporter
I8T81_10345	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I8T81_10350	COG4773	Receptor
I8T81_10370	COG0730	response to heat
I8T81_10375	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I8T81_10390	COG0406	alpha-ribazole phosphatase activity
I8T81_10395	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I8T81_10410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I8T81_10415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I8T81_10430	COG1960	acyl-CoA dehydrogenase activity
I8T81_10435	COG1960	acyl-CoA dehydrogenase activity
I8T81_10440	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I8T81_10445	COG2207	Transcriptional regulator
I8T81_10450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I8T81_10455	COG0776	regulation of translation
I8T81_10480	COG0822	iron-sulfur transferase activity
I8T81_10485	COG0316	Belongs to the HesB IscA family
I8T81_10515	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I8T81_10535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I8T81_10540	COG0702	epimerase
I8T81_10570	COG4172	Belongs to the ABC transporter superfamily
I8T81_10575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8T81_10580	COG0601	transmembrane transport
I8T81_10585	COG0339	signal peptide processing
I8T81_10635	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I8T81_10640	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I8T81_10655	COG2431	L-lysine efflux transmembrane transporter activity
I8T81_10670	COG0776	regulation of translation
I8T81_10735	COG0084	hydrolase, TatD family'
I8T81_10755	COG1663	tetraacyldisaccharide 4'-kinase activity
I8T81_10760	COG1132	(ABC) transporter
I8T81_10770	COG0811	peptide transport
I8T81_10775	COG1475	DNA binding
I8T81_10780	COG1192	Involved in chromosome partitioning
I8T81_10790	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I8T81_10805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I8T81_10830	COG0424	maF-like protein
I8T81_10835	COG2850	peptidyl-arginine hydroxylation
I8T81_10845	COG0640	Transcriptional regulator
I8T81_10855	COG3619	membrane
I8T81_10860	COG3122	Protein conserved in bacteria
I8T81_10865	COG1132	(ABC) transporter
I8T81_10885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I8T81_10890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8T81_10900	COG0506	proline dehydrogenase activity
I8T81_10900	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I8T81_10900	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I8T81_10905	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I8T81_10920	COG3698	Phosphodiester glycosidase
I8T81_10930	COG2353	YceI-like domain
I8T81_10945	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I8T81_10985	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I8T81_10985	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I8T81_11010	COG3539	Fimbrial protein
I8T81_11015	COG3121	Chaperone
I8T81_11035	COG0697	spore germination
I8T81_11045	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I8T81_11055	COG0583	DNA-binding transcription factor activity
I8T81_11100	COG1522	sequence-specific DNA binding
I8T81_11110	COG1126	abc transporter atp-binding protein
I8T81_11115	COG0765	amino acid transport
I8T81_11120	COG0765	amino acid transport
I8T81_11150	COG1464	Belongs to the NlpA lipoprotein family
I8T81_11160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I8T81_11165	COG2011	ABC-type metal ion transport system permease component
I8T81_11170	COG0012	GTP binding
I8T81_11195	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I8T81_11235	COG0386	Belongs to the glutathione peroxidase family
I8T81_11245	COG0436	Aminotransferase
I8T81_11250	COG1301	dicarboxylic acid transport
I8T81_11285	COG3634	alkyl hydroperoxide reductase activity
I8T81_11300	COG0583	DNA-binding transcription factor activity
I8T81_11305	COG0431	NADPH-dependent FMN reductase
I8T81_11310	COG0798	PFAM Bile acid sodium symporter
I8T81_11315	COG0640	Transcriptional regulator
I8T81_11330	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I8T81_11340	COG0583	DNA-binding transcription factor activity
I8T81_11350	COG1953	Uracil, thiamine, allantoin
I8T81_11360	COG2175	clavaminate synthase activity
I8T81_11365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I8T81_11370	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I8T81_11375	COG4521	taurine ABC transporter
I8T81_11385	COG0477	Major facilitator Superfamily
I8T81_11405	COG1271	oxidase subunit
I8T81_11410	COG1294	oxidase, subunit
I8T81_11420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8T81_11430	COG0300	oxidoreductase activity
I8T81_11455	COG1346	cytolysis
I8T81_11465	COG0583	DNA-binding transcription factor activity
I8T81_11470	COG0625	glutathione transferase activity
I8T81_11475	COG0625	glutathione transferase activity
I8T81_11480	COG0583	DNA-binding transcription factor activity
I8T81_11495	COG1045	serine acetyltransferase
I8T81_11500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I8T81_11505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I8T81_11510	COG1280	lysine exporter protein (LysE YggA)
I8T81_11525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8T81_11530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8T81_11540	COG0765	amino acid transport
I8T81_11545	COG0765	amino acid transport
I8T81_11585	COG2205	protein histidine kinase activity
I8T81_11585	COG0784	Response regulator, receiver
I8T81_11605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I8T81_11655	COG0583	DNA-binding transcription factor activity
I8T81_11675	COG0318	PFAM AMP-dependent synthetase and ligase
I8T81_11680	COG1309	transcriptional regulator
I8T81_11685	COG1960	acyl-CoA dehydrogenase activity
I8T81_11690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8T81_11695	COG1024	Enoyl-CoA hydratase
I8T81_11700	COG4770	biotin carboxylase activity
I8T81_11710	COG0583	DNA-binding transcription factor activity
I8T81_11735	COG2814	Major facilitator Superfamily
I8T81_11745	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I8T81_11750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I8T81_11755	COG2814	Major facilitator Superfamily
I8T81_11760	COG1960	acyl-CoA dehydrogenase activity
I8T81_11765	COG1024	Enoyl-CoA hydratase
I8T81_11770	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_11775	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8T81_11780	COG0183	Belongs to the thiolase family
I8T81_11790	COG2814	Major facilitator Superfamily
I8T81_11805	COG1024	Enoyl-CoA hydratase
I8T81_11815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I8T81_11820	COG1960	acyl-CoA dehydrogenase activity
I8T81_11825	COG2814	Major facilitator Superfamily
I8T81_11830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I8T81_11835	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I8T81_11850	COG3842	ATPase activity
I8T81_11855	COG1840	ABC-type Fe3 transport system, periplasmic component
I8T81_11870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8T81_11875	COG1414	Transcriptional regulator
I8T81_11885	COG0583	DNA-binding transcription factor activity
I8T81_11900	COG1073	alpha beta
I8T81_11905	COG1073	alpha beta
I8T81_11915	COG0531	amino acid
I8T81_11920	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I8T81_11935	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I8T81_11940	COG1309	transcriptional regulator
I8T81_11960	COG0406	alpha-ribazole phosphatase activity
I8T81_11985	COG3179	chitinase
I8T81_12015	COG2050	protein possibly involved in aromatic compounds catabolism
I8T81_12025	COG3327	negative regulation of DNA-templated transcription, initiation
I8T81_12030	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I8T81_12035	COG0183	Belongs to the thiolase family
I8T81_12040	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8T81_12045	COG1024	Enoyl-CoA hydratase
I8T81_12050	COG1024	Enoyl-CoA hydratase
I8T81_12055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I8T81_12060	COG2151	metal-sulfur cluster biosynthetic enzyme
I8T81_12065	COG3396	Phenylacetate-CoA oxygenase
I8T81_12070	COG3460	Phenylacetate-CoA oxygenase
I8T81_12075	COG3396	Phenylacetate-CoA oxygenase
I8T81_12080	COG2030	dehydratase
I8T81_12080	COG1012	belongs to the aldehyde dehydrogenase family
I8T81_12085	COG1760	l-serine dehydratase
I8T81_12095	COG0789	Transcriptional regulator
I8T81_12105	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I8T81_12110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8T81_12125	COG2807	transmembrane transport
I8T81_12130	COG0590	tRNA wobble adenosine to inosine editing
I8T81_12175	COG2885	chlorophyll binding
I8T81_12235	COG0477	Major facilitator Superfamily
I8T81_12250	COG1116	anion transmembrane transporter activity
I8T81_12255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8T81_12265	COG0864	Transcriptional regulator
I8T81_12275	COG1733	regulation of RNA biosynthetic process
I8T81_12280	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8T81_12285	COG0439	Biotin carboxylase
I8T81_12300	COG1063	alcohol dehydrogenase
I8T81_12345	COG0038	chloride channel
I8T81_12350	COG4770	biotin carboxylase activity
I8T81_12370	COG1914	H( )-stimulated, divalent metal cation uptake system
I8T81_12375	COG0583	DNA-binding transcription factor activity
I8T81_12385	COG1595	DNA-templated transcription, initiation
I8T81_12395	COG3220	belongs to the UPF0276 family
I8T81_12410	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_12425	COG2076	Multidrug Resistance protein
I8T81_12440	COG3713	MltA-interacting MipA family protein
I8T81_12445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8T81_12470	COG3209	COG3209 Rhs family protein
I8T81_12535	COG1309	transcriptional regulator
I8T81_12540	COG1278	Cold shock
I8T81_12550	COG0626	cystathionine gamma-synthase activity
I8T81_12560	COG1522	sequence-specific DNA binding
I8T81_12570	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_12580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8T81_12585	COG4774	siderophore transport
I8T81_12620	COG2814	Major facilitator Superfamily
I8T81_12635	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
I8T81_12655	COG1271	oxidase subunit
I8T81_12660	COG1294	oxidase, subunit
I8T81_12670	COG1469	GTP cyclohydrolase I activity
I8T81_12690	COG1560	Kdo2-lipid A biosynthetic process
I8T81_12735	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I8T81_12745	COG4122	O-methyltransferase activity
I8T81_12775	COG1538	Outer membrane efflux protein
I8T81_12780	COG1137	ATPase activity
I8T81_12785	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I8T81_12795	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I8T81_12800	COG0517	IMP dehydrogenase activity
I8T81_12800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I8T81_12820	COG0667	Aldo Keto reductase
I8T81_12830	COG2814	Major facilitator Superfamily
I8T81_12860	COG1278	Cold shock
I8T81_12865	COG1280	lysine exporter protein (LysE YggA)
I8T81_12895	COG1570	exodeoxyribonuclease VII activity
I8T81_12925	COG3791	Glutathione-dependent formaldehyde-activating
I8T81_12980	COG2871	sodium ion transport
I8T81_12990	COG0583	DNA-binding transcription factor activity
I8T81_13000	COG4638	Rieske (2fe-2S)
I8T81_13005	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I8T81_13010	COG0543	2 iron, 2 sulfur cluster binding
I8T81_13010	COG0633	Ferredoxin
I8T81_13015	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_13020	COG3135	benzoate transporter
I8T81_13025	COG2814	Major facilitator Superfamily
I8T81_13040	COG1643	Atp-dependent helicase
I8T81_13055	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I8T81_13065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I8T81_13075	COG3634	alkyl hydroperoxide reductase activity
I8T81_13095	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I8T81_13110	COG0625	glutathione transferase activity
I8T81_13155	COG0542	response to heat
I8T81_13175	COG1765	OsmC-like protein
I8T81_13185	COG0667	Aldo Keto reductase
I8T81_13200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I8T81_13215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I8T81_13225	COG0527	aspartate kinase activity
I8T81_13235	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I8T81_13245	COG3038	cytochrome b561
I8T81_13250	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I8T81_13255	COG2252	PERMEase
I8T81_13265	COG2072	flavoprotein involved in K transport
I8T81_13280	COG1741	Belongs to the pirin family
I8T81_13285	COG1309	transcriptional regulator
I8T81_13295	COG0300	oxidoreductase activity
I8T81_13300	COG2072	flavoprotein involved in K transport
I8T81_13305	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I8T81_13335	COG1944	ATP diphosphatase activity
I8T81_13355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I8T81_13370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I8T81_13385	COG2814	Major facilitator Superfamily
I8T81_13390	COG1024	Enoyl-CoA hydratase
I8T81_13395	COG1012	belongs to the aldehyde dehydrogenase family
I8T81_13405	COG1960	acyl-CoA dehydrogenase activity
I8T81_13430	COG0697	spore germination
I8T81_13450	COG1113	amino acid transport
I8T81_13470	COG1012	belongs to the aldehyde dehydrogenase family
I8T81_13490	COG0531	amino acid
I8T81_13500	COG1113	amino acid transport
I8T81_13535	COG1846	Transcriptional regulator
I8T81_13620	COG0583	DNA-binding transcription factor activity
I8T81_13630	COG0251	oxidation-reduction process
I8T81_13645	COG1902	pentaerythritol trinitrate reductase activity
I8T81_13645	COG0446	pyridine nucleotide-disulphide oxidoreductase
I8T81_13655	COG4251	negative regulation of phosphorylation
I8T81_13655	COG2203	Gaf domain
I8T81_13655	COG3706	GGDEF domain
I8T81_13655	COG5001	Diguanylate cyclase
I8T81_13665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I8T81_13690	COG4172	Belongs to the ABC transporter superfamily
I8T81_13695	COG4239	(ABC) transporter, permease
I8T81_13700	COG4174	ABC transporter (Permease)
I8T81_13710	COG0741	lytic transglycosylase activity
I8T81_13710	COG1388	LysM domain
I8T81_13710	COG1388	LysM domain
I8T81_13710	COG0741	lytic transglycosylase activity
I8T81_13755	COG0583	DNA-binding transcription factor activity
I8T81_13760	COG1279	arginine transmembrane transporter activity
I8T81_13780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8T81_13785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8T81_13790	COG0006	proline dipeptidase activity
I8T81_13825	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I8T81_13870	COG3384	dioxygenase
I8T81_13880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I8T81_13885	COG2878	Part of a membrane complex involved in electron transport
I8T81_13890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I8T81_13915	COG0768	penicillin binding
I8T81_13920	COG0742	ribosomal rna small subunit methyltransferase
I8T81_13940	COG0830	nickel cation binding
I8T81_13950	COG0804	urea catabolic process
I8T81_13990	COG1253	flavin adenine dinucleotide binding
I8T81_13995	COG2851	Citrate transporter
I8T81_14045	COG1773	rubredoxin
I8T81_14050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I8T81_14060	COG0583	DNA-binding transcription factor activity
I8T81_14085	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I8T81_14090	COG4181	ATPase activity
I8T81_14135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I8T81_14155	COG0306	phosphate transporter
I8T81_14180	COG2223	nitrite transmembrane transporter activity
I8T81_14185	COG2207	Transcriptional regulator
I8T81_14190	COG2066	Belongs to the glutaminase family
I8T81_14195	COG0242	peptide deformylase activity
I8T81_14200	COG0477	Major facilitator Superfamily
I8T81_14210	COG0028	Belongs to the TPP enzyme family
I8T81_14225	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_14230	COG2267	carboxylic ester hydrolase activity
I8T81_14240	COG2271	Major facilitator Superfamily
I8T81_14275	COG1414	Transcriptional regulator
I8T81_14305	COG1024	Enoyl-CoA hydratase
I8T81_14315	COG1215	transferase activity, transferring glycosyl groups
I8T81_14320	COG0726	polysaccharide deacetylase
I8T81_14320	COG1649	PFAM Uncharacterised BCR, COG1649
I8T81_14330	COG4681	YaeQ
I8T81_14340	COG0523	cobalamin synthesis protein
I8T81_14350	COG1607	acyl-coa hydrolase
I8T81_14360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I8T81_14365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I8T81_14370	COG1309	transcriptional regulator
I8T81_14395	COG2040	homocysteine
I8T81_14400	COG0531	amino acid
I8T81_14420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I8T81_14425	COG0477	Major facilitator Superfamily
I8T81_14470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I8T81_14480	COG0405	Gamma-glutamyltransferase
I8T81_14485	COG2814	Major facilitator Superfamily
I8T81_14495	COG2050	protein possibly involved in aromatic compounds catabolism
I8T81_14510	COG1090	epimerase
I8T81_14530	COG0420	3'-5' exonuclease activity
I8T81_14540	COG1968	undecaprenyl-diphosphatase activity
I8T81_14560	COG0735	belongs to the Fur family
I8T81_14565	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I8T81_14570	COG2914	Belongs to the UPF0125 (RnfH) family
I8T81_14585	COG0121	glutamine amidotransferase
I8T81_14600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I8T81_14610	COG0210	DNA helicase
I8T81_14615	COG2885	chlorophyll binding
I8T81_14620	COG0204	Acyl-transferase
I8T81_14635	COG2894	cell division
I8T81_14650	COG1280	lysine exporter protein (LysE YggA)
I8T81_14655	COG1674	ftsk spoiiie
I8T81_14660	COG0492	ferredoxin-NADP+ reductase activity
I8T81_14665	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I8T81_14675	COG0456	acetyltransferase
I8T81_14695	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I8T81_14705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I8T81_14720	COG1981	membrane
I8T81_14730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I8T81_14730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I8T81_14750	COG1012	belongs to the aldehyde dehydrogenase family
I8T81_14755	COG4638	Rieske (2fe-2S)
I8T81_14770	COG0473	3-isopropylmalate dehydrogenase activity
I8T81_14775	COG0583	DNA-binding transcription factor activity
I8T81_14795	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I8T81_14820	COG0564	pseudouridine synthase activity
I8T81_14830	COG0358	DNA primase activity
I8T81_14845	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I8T81_14875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I8T81_14905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I8T81_14915	COG0352	thiamine-phosphate diphosphorylase activity
I8T81_14915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I8T81_14915	COG0351	phosphomethylpyrimidine kinase
I8T81_14920	COG1652	LysM domain
I8T81_14945	COG1399	metal-binding, possibly nucleic acid-binding protein
I8T81_14950	COG3101	peptidyl-lysine hydroxylation
I8T81_14955	COG0009	L-threonylcarbamoyladenylate synthase
I8T81_14960	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I8T81_14965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I8T81_14980	COG4106	trans-aconitate 2-methyltransferase activity
I8T81_14995	COG0596	Alpha beta hydrolase
I8T81_14995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I8T81_14995	COG2226	methyltransferase
I8T81_15000	COG1877	trehalose-phosphatase activity
I8T81_15005	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I8T81_15010	COG2223	nitrite transmembrane transporter activity
I8T81_15030	COG1196	nuclear chromosome segregation
I8T81_15040	COG0730	response to heat
I8T81_15055	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I8T81_15065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I8T81_15110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I8T81_15115	COG0489	protein tyrosine kinase activity
I8T81_15125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8T81_15125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8T81_15160	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I8T81_15165	COG2081	HI0933 family
I8T81_15175	COG0668	transmembrane transport
I8T81_15195	COG0583	DNA-binding transcription factor activity
I8T81_15220	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I8T81_15225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I8T81_15240	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I8T81_15255	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I8T81_15280	COG3706	GGDEF domain
I8T81_15295	COG0745	RESPONSE REGULATOR receiver
I8T81_15315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8T81_15345	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I8T81_15350	COG0583	DNA-binding transcription factor activity
I8T81_15355	COG0604	alcohol dehydrogenase
I8T81_15360	COG1309	transcriptional regulator
I8T81_15415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I8T81_15430	COG0583	DNA-binding transcription factor activity
I8T81_15440	COG0583	DNA-binding transcription factor activity
I8T81_15455	COG0583	DNA-binding transcription factor activity
I8T81_15460	COG1053	succinate dehydrogenase
I8T81_15475	COG1309	transcriptional regulator
I8T81_15485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I8T81_15490	COG2814	Major facilitator Superfamily
I8T81_15495	COG1960	acyl-CoA dehydrogenase activity
I8T81_15500	COG0583	DNA-binding transcription factor activity
I8T81_15505	COG1063	alcohol dehydrogenase
I8T81_15535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I8T81_15540	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I8T81_15545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I8T81_15565	COG2132	Multicopper oxidase
I8T81_15575	COG0561	phosphatase activity
I8T81_15580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I8T81_15590	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I8T81_15605	COG1214	PFAM Peptidase M22, glycoprotease
I8T81_15665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I8T81_15670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I8T81_15675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I8T81_15735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I8T81_15745	COG1846	Transcriptional regulator
I8T81_15750	COG1764	response to oxidative stress
I8T81_15775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8T81_15775	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8T81_15790	COG0037	tRNA processing
I8T81_15800	COG0248	Ppx GppA phosphatase
I8T81_15830	COG0072	phenylalanine-tRNA ligase activity
I8T81_15860	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I8T81_15870	COG1238	metal cluster binding
I8T81_15875	COG0625	glutathione transferase activity
I8T81_15890	COG0318	PFAM AMP-dependent synthetase and ligase
I8T81_15895	COG3028	Belongs to the UPF0307 family
I8T81_15920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I8T81_15925	COG0617	tRNA 3'-terminal CCA addition
I8T81_15935	COG3956	TIGRFAM MazG family protein
I8T81_15945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I8T81_15965	COG2205	protein histidine kinase activity
I8T81_15965	COG5002	protein histidine kinase activity
I8T81_15965	COG0784	Response regulator, receiver
I8T81_15970	COG1024	Enoyl-CoA hydratase
I8T81_15975	COG2084	Dehydrogenase
I8T81_15980	COG3622	Belongs to the hyi family
I8T81_16020	COG0697	spore germination
I8T81_16030	COG2814	Major facilitator Superfamily
I8T81_16035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I8T81_16045	COG0583	DNA-binding transcription factor activity
I8T81_16055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I8T81_16065	COG0084	hydrolase, TatD family'
I8T81_16080	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I8T81_16105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I8T81_16110	COG0440	acetolactate synthase activity
I8T81_16115	COG0028	Belongs to the TPP enzyme family
I8T81_16140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I8T81_16145	COG0577	efflux transmembrane transporter activity
I8T81_16145	COG1136	(ABC) transporter
I8T81_16150	COG1538	Outer membrane efflux protein
I8T81_16165	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I8T81_16170	COG1162	GTPase activity
I8T81_16180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I8T81_16220	COG1426	Protein conserved in bacteria
I8T81_16255	COG0793	Belongs to the peptidase S41A family
I8T81_16270	COG2267	carboxylic ester hydrolase activity
I8T81_16280	COG1012	belongs to the aldehyde dehydrogenase family
I8T81_16285	COG3265	gluconokinase activity
I8T81_16295	COG0800	Aldolase
I8T81_16305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I8T81_16310	COG0280	phosphate acetyltransferase
I8T81_16310	COG0857	belongs to the CobB CobQ family
I8T81_16315	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I8T81_16315	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I8T81_16335	COG0740	serine-type endopeptidase activity
I8T81_16345	COG4774	siderophore transport
I8T81_16355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I8T81_16365	COG2813	Specifically methylates the guanine in position
I8T81_16365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I8T81_16460	COG0788	formyltetrahydrofolate deformylase activity
I8T81_16485	COG4651	solute:proton antiporter activity
I8T81_16485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I8T81_16505	COG0724	RNA recognition motif
I8T81_16510	COG0210	DNA helicase
I8T81_16535	COG1733	regulation of RNA biosynthetic process
I8T81_16545	COG2900	Belongs to the SlyX family
I8T81_16550	COG0488	(ABC) transporter
I8T81_16560	COG1280	lysine exporter protein (LysE YggA)
I8T81_16565	COG1560	Kdo2-lipid A biosynthetic process
I8T81_16575	COG1301	dicarboxylic acid transport
I8T81_16630	COG0473	3-isopropylmalate dehydrogenase activity
I8T81_16655	COG0583	DNA-binding transcription factor activity
I8T81_16700	COG0583	DNA-binding transcription factor activity
I8T81_16710	COG0625	glutathione transferase activity
I8T81_16715	COG2378	regulation of single-species biofilm formation
I8T81_16730	COG1530	ribonuclease E activity
I8T81_16735	COG0318	PFAM AMP-dependent synthetase and ligase
I8T81_16750	COG0583	DNA-binding transcription factor activity
I8T81_16755	COG4221	oxidoreductase activity
I8T81_16760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I8T81_16770	COG0534	Mate efflux family protein
I8T81_16785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I8T81_16815	COG0493	'glutamate synthase
I8T81_16815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I8T81_16825	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I8T81_16830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8T81_16845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I8T81_16855	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I8T81_16855	COG0644	oxidoreductase
I8T81_16870	COG4535	Mg2 and Co2 transporter CorC
I8T81_16880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8T81_16905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I8T81_16910	COG0475	glutathione-regulated potassium exporter activity
I8T81_16910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I8T81_16915	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I8T81_16920	COG1280	lysine exporter protein (LysE YggA)
I8T81_16925	COG0484	heat shock protein binding
I8T81_16930	COG0789	Transcriptional regulator
I8T81_16935	COG0598	Magnesium transport protein CorA
I8T81_16940	COG1185	polyribonucleotide nucleotidyltransferase activity
I8T81_16950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8T81_16955	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I8T81_16960	COG1074	ATP-dependent DNA helicase activity
I8T81_16965	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I8T81_16990	COG2226	methyltransferase
I8T81_17005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8T81_17020	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I8T81_17035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I8T81_17035	COG2111	Na H antiporter
I8T81_17040	COG1006	Multisubunit Na H antiporter MnhC subunit
I8T81_17045	COG0651	ATP synthesis coupled electron transport
I8T81_17050	COG1863	multisubunit Na H antiporter MnhE subunit
I8T81_17055	COG2212	antiporter activity
I8T81_17060	COG1320	monovalent cation:proton antiporter activity
I8T81_17065	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I8T81_17075	COG0195	Participates in both transcription termination and antitermination
I8T81_17125	COG0237	dephospho-CoA kinase activity
I8T81_17135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I8T81_17145	COG0497	DNA recombination
I8T81_17155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I8T81_17170	COG1289	transmembrane transporter activity
I8T81_17185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I8T81_17245	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I8T81_17260	COG0326	Molecular chaperone. Has ATPase activity
I8T81_17275	COG2056	Na+-H+ antiporter family
I8T81_17280	COG0596	Alpha beta hydrolase
I8T81_17375	COG0546	phosphoglycolate phosphatase activity
I8T81_17380	COG1716	ATPase activity
I8T81_17425	COG0181	hydroxymethylbilane synthase activity
I8T81_17435	COG3275	phosphorelay sensor kinase activity
I8T81_17455	COG1538	Outer membrane efflux protein
I8T81_17460	COG0697	spore germination
I8T81_17480	COG0494	nUDIX hydrolase
I8T81_17490	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I8T81_17495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I8T81_17500	COG0772	Belongs to the SEDS family
I8T81_17525	COG4974	Belongs to the 'phage' integrase family
I8T81_17530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I8T81_17540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I8T81_17550	COG2197	response regulator
I8T81_17565	COG0793	Belongs to the peptidase S41A family
I8T81_17570	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I8T81_17575	COG0795	lipopolysaccharide-transporting ATPase activity
I8T81_17580	COG0795	lipopolysaccharide-transporting ATPase activity
I8T81_17615	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I8T81_17615	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I8T81_17625	COG0004	ammonium transporteR
I8T81_17630	COG0347	Belongs to the P(II) protein family
I8T81_17640	COG0606	chelatase, subunit chli
I8T81_17645	COG0431	NADPH-dependent FMN reductase
I8T81_17650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8T81_17655	COG0235	Class ii aldolase
I8T81_17660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I8T81_17675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I8T81_17690	COG0318	PFAM AMP-dependent synthetase and ligase
I8T81_17700	COG0477	Major facilitator Superfamily
I8T81_17705	COG2860	membrane
I8T81_17715	COG1253	flavin adenine dinucleotide binding
I8T81_17725	COG2814	Major facilitator Superfamily
I8T81_17735	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I8T81_17740	COG0745	RESPONSE REGULATOR receiver
I8T81_17745	COG2205	protein histidine kinase activity
I8T81_17750	COG4452	Inner membrane protein CreD
I8T81_17790	COG0655	NAD(P)H dehydrogenase (quinone) activity
I8T81_17805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8T81_17840	COG1309	transcriptional regulator
I8T81_17875	COG0758	DNA mediated transformation
I8T81_17885	COG0697	spore germination
I8T81_17890	COG1309	transcriptional regulator
I8T81_17905	COG0386	Belongs to the glutathione peroxidase family
I8T81_17915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I8T81_17920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I8T81_17970	COG1121	(ABC) transporter
I8T81_17975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I8T81_17980	COG1280	lysine exporter protein (LysE YggA)
I8T81_17985	COG2837	iron assimilation
I8T81_17995	COG0281	malic enzyme
I8T81_18030	COG0735	belongs to the Fur family
I8T81_18040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8T81_18045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I8T81_18045	COG0519	Catalyzes the synthesis of GMP from XMP
I8T81_18050	COG4399	Belongs to the UPF0754 family
I8T81_18050	COG4399	Belongs to the UPF0754 family
I8T81_18055	COG2259	Doxx family
I8T81_18060	COG0586	Pfam SNARE associated Golgi protein
I8T81_18075	COG1192	Involved in chromosome partitioning
I8T81_18085	COG0271	Belongs to the BolA IbaG family
I8T81_18125	COG3321	synthase
I8T81_18125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8T81_18125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I8T81_18125	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I8T81_18130	COG1960	acyl-CoA dehydrogenase activity
I8T81_18140	COG2197	response regulator
I8T81_18150	COG3916	Acyl-homoserine-lactone synthase
I8T81_18155	COG0477	Major facilitator Superfamily
I8T81_18160	COG1024	Enoyl-CoA hydratase
I8T81_18165	COG1024	Enoyl-CoA hydratase
I8T81_18170	COG1960	acyl-CoA dehydrogenase activity
I8T81_18175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I8T81_18195	COG1113	amino acid transport
I8T81_18200	COG1113	amino acid transport
I8T81_18205	COG0251	oxidation-reduction process
I8T81_18245	COG0564	pseudouridine synthase activity
I8T81_18350	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I8T81_18365	COG1802	Transcriptional regulator
I8T81_18370	COG1448	Aminotransferase
I8T81_18375	COG0277	FAD linked oxidase domain protein
I8T81_18385	COG2186	Transcriptional regulator
I8T81_18395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I8T81_18415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I8T81_18420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I8T81_18435	COG0110	maltose O-acetyltransferase activity
I8T81_18465	COG2244	polysaccharide biosynthetic process
I8T81_18475	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I8T81_18480	COG1091	dTDP-4-dehydrorhamnose reductase activity
I8T81_18490	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I8T81_18495	COG1596	polysaccharide export
I8T81_18520	COG0728	peptidoglycan biosynthetic process
I8T81_18525	COG3023	N-Acetylmuramoyl-L-alanine amidase
I8T81_18580	COG0546	phosphoglycolate phosphatase activity
I8T81_18585	COG1028	Short-chain dehydrogenase reductase Sdr
I8T81_18600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I8T81_18600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I8T81_18605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I8T81_18610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I8T81_18615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8T81_18620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I8T81_18625	COG1116	anion transmembrane transporter activity
I8T81_18630	COG1309	transcriptional regulator
I8T81_18635	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I8T81_18645	COG0196	riboflavin kinase activity
I8T81_18650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I8T81_18660	COG1047	Peptidyl-prolyl cis-trans
I8T81_18700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I8T81_18705	COG0657	acetylesterase activity
I8T81_18755	COG2951	lytic endotransglycosylase activity
I8T81_18760	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I8T81_18775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I8T81_18785	COG0671	phosphoesterase, PA-phosphatase related
I8T81_18790	COG0861	Integral membrane protein TerC family
I8T81_18805	COG0402	S-adenosylhomocysteine deaminase activity
I8T81_18820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process