locus-tag	class	description
E5Y90_00010	COG0592	DNA-directed DNA polymerase activity
E5Y90_00025	COG1063	alcohol dehydrogenase
E5Y90_00030	COG0488	(ABC) transporter
E5Y90_00050	COG0316	Belongs to the HesB IscA family
E5Y90_00090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5Y90_00125	COG2814	Major facilitator Superfamily
E5Y90_00130	COG2814	Major facilitator Superfamily
E5Y90_00140	COG0666	response to abiotic stimulus
E5Y90_00145	COG0693	protein deglycase activity
E5Y90_00155	COG1012	belongs to the aldehyde dehydrogenase family
E5Y90_00160	COG0733	neurotransmitter:sodium symporter activity
E5Y90_00170	COG0428	transporter
E5Y90_00195	COG0129	dihydroxy-acid dehydratase activity
E5Y90_00220	COG2233	PERMEase
E5Y90_00235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5Y90_00285	COG2733	membrane
E5Y90_00300	COG2918	glutathione biosynthetic process
E5Y90_00305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E5Y90_00315	COG3150	esterase
E5Y90_00360	COG3706	GGDEF domain
E5Y90_00365	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E5Y90_00380	COG1393	Belongs to the ArsC family
E5Y90_00385	COG0708	Exodeoxyribonuclease III
E5Y90_00400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5Y90_00410	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E5Y90_00415	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E5Y90_00445	COG4771	TonB-dependent receptor
E5Y90_00495	COG4521	taurine ABC transporter
E5Y90_00500	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E5Y90_00505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5Y90_00510	COG2175	clavaminate synthase activity
E5Y90_00520	COG2186	Transcriptional regulator
E5Y90_00530	COG0277	FAD linked oxidase domain protein
E5Y90_00580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E5Y90_00670	COG1074	ATP-dependent DNA helicase activity
E5Y90_00685	COG4372	Transposase
E5Y90_00695	COG2963	transposase activity
E5Y90_00730	COG3727	T/G mismatch-specific endonuclease activity
E5Y90_00735	COG0270	DNA (cytosine-5-)-methyltransferase activity
E5Y90_00775	COG3756	Protein conserved in bacteria
E5Y90_00820	COG1192	Involved in chromosome partitioning
E5Y90_00835	COG0586	Pfam SNARE associated Golgi protein
E5Y90_00840	COG3111	PFAM Bacterial OB fold (BOF) protein
E5Y90_00845	COG0519	Catalyzes the synthesis of GMP from XMP
E5Y90_00845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5Y90_00850	COG3706	GGDEF domain
E5Y90_00885	COG0534	Mate efflux family protein
E5Y90_00935	COG3158	transport of potassium into the cell
E5Y90_00970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E5Y90_01005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5Y90_01060	COG0183	Belongs to the thiolase family
E5Y90_01095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5Y90_01115	COG3275	phosphorelay sensor kinase activity
E5Y90_01125	COG0181	hydroxymethylbilane synthase activity
E5Y90_01145	COG0824	Thioesterase
E5Y90_01175	COG0546	phosphoglycolate phosphatase activity
E5Y90_01225	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E5Y90_01230	COG0081	regulation of translation
E5Y90_01235	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E5Y90_01245	COG0085	RNA polymerase activity
E5Y90_01275	COG2056	Na+-H+ antiporter family
E5Y90_01290	COG0326	Molecular chaperone. Has ATPase activity
E5Y90_01315	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E5Y90_01320	COG0427	acetyl-CoA hydrolase
E5Y90_01325	COG2205	protein histidine kinase activity
E5Y90_01330	COG0745	RESPONSE REGULATOR receiver
E5Y90_01350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5Y90_01380	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E5Y90_01385	COG1074	ATP-dependent DNA helicase activity
E5Y90_01390	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5Y90_01400	COG1185	polyribonucleotide nucleotidyltransferase activity
E5Y90_01405	COG0598	Magnesium transport protein CorA
E5Y90_01410	COG2841	Protein conserved in bacteria
E5Y90_01415	COG0789	Transcriptional regulator
E5Y90_01425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E5Y90_01435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5Y90_01460	COG4535	Mg2 and Co2 transporter CorC
E5Y90_01465	COG0425	Belongs to the sulfur carrier protein TusA family
E5Y90_01470	COG3501	Rhs element vgr protein
E5Y90_01485	COG0644	oxidoreductase
E5Y90_01485	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E5Y90_01495	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5Y90_01510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5Y90_01520	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E5Y90_01530	COG0493	'glutamate synthase
E5Y90_01540	COG2226	methyltransferase
E5Y90_01555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5Y90_01575	COG0751	glycine-tRNA ligase activity
E5Y90_01590	COG0471	metal ion transport
E5Y90_01600	COG1983	PspC domain protein
E5Y90_01625	COG0318	PFAM AMP-dependent synthetase and ligase
E5Y90_01630	COG1530	ribonuclease E activity
E5Y90_01645	COG0546	phosphoglycolate phosphatase activity
E5Y90_01650	COG3971	2-oxopent-4-enoate hydratase activity
E5Y90_01655	COG4569	acetaldehyde dehydrogenase (acetylating) activity
E5Y90_01675	COG2963	transposase activity
E5Y90_01685	COG4372	Transposase
E5Y90_01690	COG0583	DNA-binding transcription factor activity
E5Y90_01695	COG4638	Rieske (2fe-2S)
E5Y90_01710	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_01715	COG3384	dioxygenase
E5Y90_01720	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5Y90_01740	COG3011	Protein conserved in bacteria
E5Y90_01745	COG0753	catalase activity
E5Y90_01750	COG1960	acyl-CoA dehydrogenase activity
E5Y90_01795	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5Y90_01810	COG0473	3-isopropylmalate dehydrogenase activity
E5Y90_01860	COG1560	Kdo2-lipid A biosynthetic process
E5Y90_01870	COG2900	Belongs to the SlyX family
E5Y90_01900	COG1929	Belongs to the glycerate kinase type-1 family
E5Y90_01910	COG0724	RNA recognition motif
E5Y90_01925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5Y90_01925	COG4651	solute:proton antiporter activity
E5Y90_01950	COG0788	formyltetrahydrofolate deformylase activity
E5Y90_01990	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E5Y90_02030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5Y90_02045	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5Y90_02050	COG0583	DNA-binding transcription factor activity
E5Y90_02060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5Y90_02060	COG2813	Specifically methylates the guanine in position
E5Y90_02065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5Y90_02070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5Y90_02080	COG4774	siderophore transport
E5Y90_02085	COG4771	TonB-dependent receptor
E5Y90_02095	COG0740	serine-type endopeptidase activity
E5Y90_02110	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E5Y90_02110	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E5Y90_02120	COG1414	Transcriptional regulator
E5Y90_02130	COG1454	alcohol dehydrogenase
E5Y90_02135	COG2610	gluconate transmembrane transporter activity
E5Y90_02140	COG0280	phosphate acetyltransferase
E5Y90_02140	COG0857	belongs to the CobB CobQ family
E5Y90_02145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5Y90_02170	COG0793	Belongs to the peptidase S41A family
E5Y90_02185	COG2814	Major facilitator Superfamily
E5Y90_02210	COG0697	spore germination
E5Y90_02220	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E5Y90_02225	COG0339	signal peptide processing
E5Y90_02235	COG0557	exoribonuclease II activity
E5Y90_02270	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5Y90_02275	COG1295	ribonuclease BN
E5Y90_02325	COG1702	phosphate starvation-inducible protein PhoH
E5Y90_02335	COG0739	heme binding
E5Y90_02335	COG1196	nuclear chromosome segregation
E5Y90_02335	COG0741	lytic transglycosylase activity
E5Y90_02375	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E5Y90_02380	COG1183	phosphatidylcholine synthase activity
E5Y90_02445	COG1607	acyl-coa hydrolase
E5Y90_02475	COG2350	Protein conserved in bacteria
E5Y90_02490	COG3781	membrane
E5Y90_02495	COG2003	Belongs to the UPF0758 family
E5Y90_02500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5Y90_02510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5Y90_02515	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E5Y90_02525	COG0726	polysaccharide deacetylase
E5Y90_02530	COG0084	hydrolase, TatD family'
E5Y90_02545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E5Y90_02555	COG1162	GTPase activity
E5Y90_02560	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E5Y90_02565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E5Y90_02575	COG1538	Outer membrane efflux protein
E5Y90_02580	COG1136	(ABC) transporter
E5Y90_02580	COG0577	efflux transmembrane transporter activity
E5Y90_02585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5Y90_02590	COG2963	transposase activity
E5Y90_02600	COG4372	Transposase
E5Y90_02630	COG0028	Belongs to the TPP enzyme family
E5Y90_02635	COG0440	acetolactate synthase activity
E5Y90_02675	COG2975	iron-sulfur cluster assembly
E5Y90_02690	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E5Y90_02695	COG1426	Protein conserved in bacteria
E5Y90_02705	COG0124	histidyl-tRNA synthetase
E5Y90_02735	COG0300	oxidoreductase activity
E5Y90_02740	COG3956	TIGRFAM MazG family protein
E5Y90_02745	COG1555	photosystem II stabilization
E5Y90_02745	COG1596	polysaccharide export
E5Y90_02750	COG0617	tRNA 3'-terminal CCA addition
E5Y90_02755	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E5Y90_02770	COG1660	Displays ATPase and GTPase activities
E5Y90_02775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5Y90_02780	COG3028	Belongs to the UPF0307 family
E5Y90_02785	COG2205	protein histidine kinase activity
E5Y90_02790	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E5Y90_02835	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E5Y90_02855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5Y90_02860	COG0463	Glycosyl transferase, family 2
E5Y90_02885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5Y90_02920	COG1960	acyl-CoA dehydrogenase activity
E5Y90_02925	COG1960	acyl-CoA dehydrogenase activity
E5Y90_02935	COG2205	protein histidine kinase activity
E5Y90_02940	COG0745	RESPONSE REGULATOR receiver
E5Y90_02950	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E5Y90_02965	COG2096	Adenosyltransferase
E5Y90_02970	COG4206	TonB-dependent receptor
E5Y90_03010	COG1764	response to oxidative stress
E5Y90_03015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5Y90_03080	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5Y90_03090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5Y90_03140	COG0494	nUDIX hydrolase
E5Y90_03150	COG1214	PFAM Peptidase M22, glycoprotease
E5Y90_03155	COG1968	undecaprenyl-diphosphatase activity
E5Y90_03170	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E5Y90_03185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5Y90_03220	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5Y90_03245	COG0730	response to heat
E5Y90_03255	COG1196	nuclear chromosome segregation
E5Y90_03265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5Y90_03275	COG2193	ferroxidase activity
E5Y90_03315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5Y90_03320	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E5Y90_03330	COG0009	L-threonylcarbamoyladenylate synthase
E5Y90_03335	COG3101	peptidyl-lysine hydroxylation
E5Y90_03340	COG1399	metal-binding, possibly nucleic acid-binding protein
E5Y90_03355	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_03360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5Y90_03365	COG1652	LysM domain
E5Y90_03385	COG0251	oxidation-reduction process
E5Y90_03390	COG1113	amino acid transport
E5Y90_03410	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5Y90_03435	COG0456	acetyltransferase
E5Y90_03450	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E5Y90_03455	COG0492	ferredoxin-NADP+ reductase activity
E5Y90_03460	COG0531	amino acid
E5Y90_03460	COG1674	ftsk spoiiie
E5Y90_03470	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E5Y90_03480	COG0850	regulation of cytokinetic process
E5Y90_03490	COG0204	Acyl-transferase
E5Y90_03495	COG2885	chlorophyll binding
E5Y90_03500	COG0210	DNA helicase
E5Y90_03505	COG0756	dUTP diphosphatase activity
E5Y90_03525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5Y90_03530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5Y90_03535	COG0121	glutamine amidotransferase
E5Y90_03560	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5Y90_03565	COG0735	belongs to the Fur family
E5Y90_03595	COG0420	3'-5' exonuclease activity
E5Y90_03605	COG1090	epimerase
E5Y90_03610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5Y90_03620	COG2050	protein possibly involved in aromatic compounds catabolism
E5Y90_03625	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5Y90_03665	COG1785	Belongs to the alkaline phosphatase family
E5Y90_03670	COG1785	Belongs to the alkaline phosphatase family
E5Y90_03770	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E5Y90_03775	COG0477	Major facilitator Superfamily
E5Y90_03785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5Y90_03790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5Y90_03795	COG0730	response to heat
E5Y90_03800	COG0583	DNA-binding transcription factor activity
E5Y90_03815	COG2207	Transcriptional regulator
E5Y90_03835	COG0543	2 iron, 2 sulfur cluster binding
E5Y90_03835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5Y90_03840	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E5Y90_03845	COG4638	Rieske (2fe-2S)
E5Y90_03875	COG4773	Receptor
E5Y90_03890	COG0583	DNA-binding transcription factor activity
E5Y90_03900	COG0657	acetylesterase activity
E5Y90_03925	COG0281	malic enzyme
E5Y90_03965	COG2871	sodium ion transport
E5Y90_03980	COG0640	Transcriptional regulator
E5Y90_04000	COG0783	Belongs to the Dps family
E5Y90_04020	COG0500	methyltransferase
E5Y90_04030	COG2223	nitrite transmembrane transporter activity
E5Y90_04035	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E5Y90_04050	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E5Y90_04095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5Y90_04105	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5Y90_04110	COG1077	Cell shape determining protein MreB Mrl
E5Y90_04115	COG1792	Involved in formation and maintenance of cell shape
E5Y90_04120	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E5Y90_04125	COG0424	maF-like protein
E5Y90_04130	COG1530	ribonuclease E activity
E5Y90_04135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5Y90_04145	COG0560	Phosphoserine phosphatase
E5Y90_04165	COG1113	amino acid transport
E5Y90_04170	COG0583	DNA-binding transcription factor activity
E5Y90_04175	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E5Y90_04180	COG4208	sulfate ABC transporter
E5Y90_04195	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E5Y90_04205	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E5Y90_04225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5Y90_04250	COG0571	ribonuclease III activity
E5Y90_04255	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5Y90_04265	COG1381	Involved in DNA repair and RecF pathway recombination
E5Y90_04270	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E5Y90_04300	COG0436	Aminotransferase
E5Y90_04310	COG0052	Belongs to the universal ribosomal protein uS2 family
E5Y90_04330	COG2951	lytic endotransglycosylase activity
E5Y90_04345	COG0842	Transport permease protein
E5Y90_04350	COG1131	(ABC) transporter
E5Y90_04365	COG0584	glycerophosphoryl diester phosphodiesterase
E5Y90_04370	COG3118	belongs to the thioredoxin family
E5Y90_04425	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E5Y90_04430	COG1053	succinate dehydrogenase
E5Y90_04435	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5Y90_04450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5Y90_04475	COG0726	polysaccharide deacetylase
E5Y90_04475	COG1649	PFAM Uncharacterised BCR, COG1649
E5Y90_04505	COG0642	Histidine kinase
E5Y90_04510	COG0745	RESPONSE REGULATOR receiver
E5Y90_04550	COG0583	DNA-binding transcription factor activity
E5Y90_04620	COG3634	alkyl hydroperoxide reductase activity
E5Y90_04625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5Y90_04635	COG0789	Transcriptional regulator
E5Y90_04650	COG1720	tRNA m6t6A37 methyltransferase activity
E5Y90_04660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5Y90_04670	COG0745	RESPONSE REGULATOR receiver
E5Y90_04675	COG0642	Histidine kinase
E5Y90_04685	COG0494	nUDIX hydrolase
E5Y90_04695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5Y90_04700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5Y90_04705	COG3139	Protein of unknown function (DUF1315)
E5Y90_04715	COG1301	dicarboxylic acid transport
E5Y90_04720	COG1960	acyl-CoA dehydrogenase activity
E5Y90_04725	COG0693	protein deglycase activity
E5Y90_04730	COG1605	Chorismate mutase
E5Y90_04730	COG0077	Prephenate dehydratase
E5Y90_04735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5Y90_04740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5Y90_04765	COG2252	PERMEase
E5Y90_04770	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5Y90_04790	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5Y90_04800	COG0527	aspartate kinase activity
E5Y90_04810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5Y90_04825	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E5Y90_04840	COG1047	Peptidyl-prolyl cis-trans
E5Y90_04850	COG1686	Belongs to the peptidase S11 family
E5Y90_04865	COG3338	carbonate dehydratase activity
E5Y90_04870	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_04890	COG2963	transposase activity
E5Y90_04900	COG4372	Transposase
E5Y90_04920	COG0584	glycerophosphoryl diester phosphodiesterase
E5Y90_04945	COG0436	Aminotransferase
E5Y90_04950	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5Y90_04955	COG0386	Belongs to the glutathione peroxidase family
E5Y90_04960	COG0436	Aminotransferase
E5Y90_04965	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E5Y90_04980	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E5Y90_05000	COG3739	integral membrane protein
E5Y90_05015	COG3706	GGDEF domain
E5Y90_05030	COG0302	gtp cyclohydrolase
E5Y90_05045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5Y90_05050	COG0512	Glutamine amidotransferase of anthranilate synthase
E5Y90_05055	COG0174	glutamine synthetase
E5Y90_05065	COG3161	chorismate lyase activity
E5Y90_05070	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E5Y90_05115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5Y90_05120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5Y90_05125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5Y90_05160	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5Y90_05165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5Y90_05195	COG0556	nucleotide-excision repair
E5Y90_05240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5Y90_05240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E5Y90_05270	COG3634	alkyl hydroperoxide reductase activity
E5Y90_05285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5Y90_05295	COG3178	'Phosphotransferase
E5Y90_05300	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E5Y90_05310	COG1192	Involved in chromosome partitioning
E5Y90_05315	COG1475	DNA binding
E5Y90_05320	COG0811	peptide transport
E5Y90_05330	COG1132	(ABC) transporter
E5Y90_05335	COG1663	tetraacyldisaccharide 4'-kinase activity
E5Y90_05355	COG0084	hydrolase, TatD family'
E5Y90_05360	COG1309	transcriptional regulator
E5Y90_05375	COG4795	General secretion pathway protein
E5Y90_05390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E5Y90_05400	COG0590	tRNA wobble adenosine to inosine editing
E5Y90_05420	COG0776	regulation of translation
E5Y90_05435	COG2431	L-lysine efflux transmembrane transporter activity
E5Y90_05450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E5Y90_05455	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E5Y90_05475	COG1253	flavin adenine dinucleotide binding
E5Y90_05490	COG0308	aminopeptidase N
E5Y90_05500	COG0589	response to stress
E5Y90_05515	COG3135	benzoate transporter
E5Y90_05525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5Y90_05530	COG0583	DNA-binding transcription factor activity
E5Y90_05545	COG0183	Belongs to the thiolase family
E5Y90_05565	COG2963	transposase activity
E5Y90_05575	COG4372	Transposase
E5Y90_05580	COG0431	NADPH-dependent FMN reductase
E5Y90_05585	COG0798	PFAM Bile acid sodium symporter
E5Y90_05590	COG0640	Transcriptional regulator
E5Y90_05595	COG1393	Belongs to the ArsC family
E5Y90_05630	COG1309	transcriptional regulator
E5Y90_05695	COG1114	Component of the transport system for branched-chain amino acids
E5Y90_05705	COG0583	DNA-binding transcription factor activity
E5Y90_05710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5Y90_05725	COG1902	pentaerythritol trinitrate reductase activity
E5Y90_05725	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5Y90_05755	COG0148	phosphopyruvate hydratase activity
E5Y90_05770	COG0772	Belongs to the SEDS family
E5Y90_05780	COG4890	Cyd operon protein YbgT
E5Y90_05785	COG1294	oxidase, subunit
E5Y90_05805	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5Y90_05815	COG0583	DNA-binding transcription factor activity
E5Y90_05865	COG2011	ABC-type metal ion transport system permease component
E5Y90_05870	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5Y90_05875	COG1464	Belongs to the NlpA lipoprotein family
E5Y90_05885	COG0138	bifunctional purine biosynthesis protein purh
E5Y90_05890	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E5Y90_05925	COG2814	Major facilitator Superfamily
E5Y90_05940	COG3852	Histidine kinase
E5Y90_05960	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5Y90_05965	COG0575	Belongs to the CDS family
E5Y90_05980	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5Y90_05990	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5Y90_05995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5Y90_06000	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5Y90_06015	COG2137	regulation of response to DNA damage stimulus
E5Y90_06020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E5Y90_06025	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E5Y90_06030	COG1011	Hydrolase
E5Y90_06050	COG0268	Binds directly to 16S ribosomal RNA
E5Y90_06055	COG0702	epimerase
E5Y90_06060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5Y90_06070	COG2850	peptidyl-arginine hydroxylation
E5Y90_06080	COG0424	maF-like protein
E5Y90_06090	COG0126	phosphoglycerate kinase activity
E5Y90_06105	COG0697	spore germination
E5Y90_06115	COG0778	Nitroreductase
E5Y90_06125	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5Y90_06135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5Y90_06140	COG3781	membrane
E5Y90_06155	COG5265	(ABC) transporter
E5Y90_06165	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5Y90_06170	COG0824	Thioesterase
E5Y90_06175	COG1454	alcohol dehydrogenase
E5Y90_06180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5Y90_06200	COG0069	glutamate synthase activity
E5Y90_06225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5Y90_06245	COG0360	Binds together with S18 to 16S ribosomal RNA
E5Y90_06255	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E5Y90_06260	COG1845	cytochrome c oxidase, subunit III
E5Y90_06265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5Y90_06270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E5Y90_06295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5Y90_06310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5Y90_06315	COG2890	protein-(glutamine-N5) methyltransferase activity
E5Y90_06335	COG1960	acyl-CoA dehydrogenase activity
E5Y90_06340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5Y90_06355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5Y90_06380	COG0477	Major facilitator Superfamily
E5Y90_06385	COG0729	surface antigen
E5Y90_06560	COG5410	chromosome segregation
E5Y90_06705	COG3179	chitinase
E5Y90_06750	COG2391	methyltransferase activity
E5Y90_06765	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E5Y90_06775	COG2826	transposase and inactivated derivatives, IS30 family
E5Y90_06780	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E5Y90_06790	COG2353	YceI-like domain
E5Y90_06800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5Y90_06800	COG0519	Catalyzes the synthesis of GMP from XMP
E5Y90_06805	COG0625	glutathione transferase activity
E5Y90_06825	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E5Y90_06825	COG0517	IMP dehydrogenase activity
E5Y90_06830	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E5Y90_06840	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E5Y90_06845	COG1137	ATPase activity
E5Y90_06850	COG1538	Outer membrane efflux protein
E5Y90_06875	COG0589	response to stress
E5Y90_06880	COG4122	O-methyltransferase activity
E5Y90_06890	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E5Y90_06910	COG2084	Dehydrogenase
E5Y90_06930	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5Y90_06950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5Y90_06960	COG0133	tryptophan synthase activity
E5Y90_06965	COG0517	IMP dehydrogenase activity
E5Y90_06995	COG0612	Peptidase, M16
E5Y90_07000	COG0552	protein localization to endoplasmic reticulum
E5Y90_07015	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
E5Y90_07060	COG1960	acyl-CoA dehydrogenase activity
E5Y90_07125	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5Y90_07130	COG0730	response to heat
E5Y90_07135	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5Y90_07140	COG2207	Transcriptional regulator
E5Y90_07145	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5Y90_07150	COG1960	acyl-CoA dehydrogenase activity
E5Y90_07155	COG2169	Transcriptional regulator
E5Y90_07170	COG1271	oxidase subunit
E5Y90_07175	COG1294	oxidase, subunit
E5Y90_07185	COG1525	nuclease
E5Y90_07190	COG0583	DNA-binding transcription factor activity
E5Y90_07230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5Y90_07235	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E5Y90_07245	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5Y90_07250	COG2814	Major facilitator Superfamily
E5Y90_07265	COG1132	(ABC) transporter
E5Y90_07270	COG0668	transmembrane transport
E5Y90_07275	COG3122	Protein conserved in bacteria
E5Y90_07295	COG0640	Transcriptional regulator
E5Y90_07300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5Y90_07305	COG2217	Heavy metal translocating P-type atpase
E5Y90_07310	COG0789	Transcriptional regulator
E5Y90_07325	COG1960	acyl-CoA dehydrogenase activity
E5Y90_07330	COG0183	Belongs to the thiolase family
E5Y90_07335	COG0427	acetyl-CoA hydrolase
E5Y90_07350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5Y90_07355	COG0183	Belongs to the thiolase family
E5Y90_07360	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5Y90_07365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E5Y90_07370	COG3135	benzoate transporter
E5Y90_07375	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_07380	COG0543	2 iron, 2 sulfur cluster binding
E5Y90_07380	COG0633	Ferredoxin
E5Y90_07385	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E5Y90_07390	COG4638	Rieske (2fe-2S)
E5Y90_07400	COG4829	muconolactone delta-isomerase
E5Y90_07405	COG4948	Mandelate Racemase Muconate Lactonizing
E5Y90_07410	COG0583	DNA-binding transcription factor activity
E5Y90_07415	COG2814	Major facilitator Superfamily
E5Y90_07425	COG0318	PFAM AMP-dependent synthetase and ligase
E5Y90_07430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5Y90_07430	COG1017	nitric oxide dioxygenase activity
E5Y90_07440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5Y90_07445	COG0583	DNA-binding transcription factor activity
E5Y90_07450	COG1944	ATP diphosphatase activity
E5Y90_07455	COG0644	oxidoreductase
E5Y90_07455	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E5Y90_07470	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_07490	COG4106	trans-aconitate 2-methyltransferase activity
E5Y90_07510	COG1454	alcohol dehydrogenase
E5Y90_07525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5Y90_07535	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5Y90_07540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E5Y90_07545	COG0022	dehydrogenase e1 component
E5Y90_07550	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5Y90_07555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5Y90_07560	COG2801	Transposase and inactivated derivatives
E5Y90_07570	COG2801	Transposase and inactivated derivatives
E5Y90_07600	COG0596	Alpha beta hydrolase
E5Y90_07655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5Y90_07665	COG0511	ligase activity, forming carbon-carbon bonds
E5Y90_07670	COG0439	Biotin carboxylase
E5Y90_07685	COG2814	Major facilitator Superfamily
E5Y90_07730	COG2199	diguanylate cyclase activity
E5Y90_07730	COG2203	Gaf domain
E5Y90_07735	COG2801	Transposase and inactivated derivatives
E5Y90_07750	COG0167	dihydroorotate dehydrogenase activity
E5Y90_07780	COG0372	Belongs to the citrate synthase family
E5Y90_07810	COG0542	response to heat
E5Y90_07815	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E5Y90_07825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E5Y90_07840	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E5Y90_07845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5Y90_07850	COG0569	domain protein
E5Y90_07855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5Y90_07875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5Y90_07885	COG1585	Membrane protein implicated in regulation of membrane protease activity
E5Y90_07905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5Y90_07935	COG0822	iron-sulfur transferase activity
E5Y90_07940	COG0316	Belongs to the HesB IscA family
E5Y90_07970	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E5Y90_07980	COG1027	Aspartate ammonia-lyase
E5Y90_08015	COG0352	thiamine-phosphate diphosphorylase activity
E5Y90_08030	COG3025	triphosphatase activity
E5Y90_08055	COG0612	Peptidase, M16
E5Y90_08065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5Y90_08135	COG0154	amidase activity
E5Y90_08140	COG0477	Major facilitator Superfamily
E5Y90_08145	COG1522	sequence-specific DNA binding
E5Y90_08160	COG1610	YqeY-like protein
E5Y90_08170	COG4783	chaperone-mediated protein folding
E5Y90_08225	COG0778	Nitroreductase
E5Y90_08235	COG0513	Belongs to the DEAD box helicase family
E5Y90_08240	COG1278	Cold shock
E5Y90_08255	COG2363	Small membrane protein
E5Y90_08285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5Y90_08305	COG0318	PFAM AMP-dependent synthetase and ligase
E5Y90_08310	COG1309	transcriptional regulator
E5Y90_08315	COG1960	acyl-CoA dehydrogenase activity
E5Y90_08320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5Y90_08325	COG1024	Enoyl-CoA hydratase
E5Y90_08330	COG4770	biotin carboxylase activity
E5Y90_08345	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5Y90_08350	COG2031	fatty acid transporter
E5Y90_08365	COG0540	Belongs to the ATCase OTCase family
E5Y90_08380	COG0667	Aldo Keto reductase
E5Y90_08390	COG1765	OsmC-like protein
E5Y90_08395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5Y90_08420	COG0714	Associated with various cellular activities
E5Y90_08430	COG1966	Carbon starvation protein
E5Y90_08435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5Y90_08440	COG1509	lysine 2,3-aminomutase activity
E5Y90_08475	COG1067	ATP-dependent peptidase activity
E5Y90_08480	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E5Y90_08485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5Y90_08495	COG0583	DNA-binding transcription factor activity
E5Y90_08505	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E5Y90_08520	COG1686	Belongs to the peptidase S11 family
E5Y90_08525	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E5Y90_08535	COG1923	regulation of RNA biosynthetic process
E5Y90_08545	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E5Y90_08550	COG0802	atpase or kinase
E5Y90_08575	COG2707	UPF0756 membrane protein
E5Y90_08580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5Y90_08585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5Y90_08600	COG1643	Atp-dependent helicase
E5Y90_08630	COG0482	sulfurtransferase activity
E5Y90_08635	COG2915	High frequency lysogenization protein hflD homolog
E5Y90_08655	COG0616	signal peptide processing
E5Y90_08665	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5Y90_08675	COG0573	inorganic phosphate transmembrane transporter activity
E5Y90_08680	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E5Y90_08685	COG0076	glutamate decarboxylase activity
E5Y90_08690	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E5Y90_08720	COG2801	Transposase and inactivated derivatives
E5Y90_08760	COG0582	viral genome integration into host DNA
E5Y90_08765	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E5Y90_08775	COG1733	regulation of RNA biosynthetic process
E5Y90_08795	COG4372	Transposase
E5Y90_08805	COG2963	transposase activity
E5Y90_08815	COG1024	Enoyl-CoA hydratase
E5Y90_08820	COG1960	acyl-CoA dehydrogenase activity
E5Y90_08825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5Y90_08840	COG0583	DNA-binding transcription factor activity
E5Y90_08850	COG0582	viral genome integration into host DNA
E5Y90_08865	COG3485	protocatechuate 3,4-dioxygenase
E5Y90_08870	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5Y90_08875	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E5Y90_08880	COG0583	DNA-binding transcription factor activity
E5Y90_08885	COG4948	Mandelate Racemase Muconate Lactonizing
E5Y90_08890	COG4829	muconolactone delta-isomerase
E5Y90_08895	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E5Y90_08900	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5Y90_08965	COG4638	Rieske (2fe-2S)
E5Y90_08970	COG0154	amidase activity
E5Y90_08995	COG4372	Transposase
E5Y90_09005	COG2963	transposase activity
E5Y90_09065	COG0012	GTP binding
E5Y90_09070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5Y90_09075	COG1741	Belongs to the pirin family
E5Y90_09105	COG1518	maintenance of DNA repeat elements
E5Y90_09115	COG2072	flavoprotein involved in K transport
E5Y90_09130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5Y90_09150	COG3842	ATPase activity
E5Y90_09155	COG1840	ABC-type Fe3 transport system, periplasmic component
E5Y90_09170	COG1902	pentaerythritol trinitrate reductase activity
E5Y90_09170	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5Y90_09185	COG5001	Diguanylate cyclase
E5Y90_09185	COG3706	GGDEF domain
E5Y90_09185	COG2203	Gaf domain
E5Y90_09185	COG4251	negative regulation of phosphorylation
E5Y90_09190	COG0418	dihydroorotase activity
E5Y90_09195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5Y90_09205	COG0833	amino acid
E5Y90_09215	COG0833	amino acid
E5Y90_09250	COG4239	(ABC) transporter, permease
E5Y90_09255	COG4174	ABC transporter (Permease)
E5Y90_09260	COG4166	transmembrane transport
E5Y90_09265	COG0741	lytic transglycosylase activity
E5Y90_09265	COG1388	LysM domain
E5Y90_09280	COG2816	NAD+ diphosphatase activity
E5Y90_09300	COG3107	peptidoglycan biosynthetic process
E5Y90_09315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5Y90_09320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5Y90_09325	COG2155	Conserved Protein
E5Y90_09330	COG0006	proline dipeptidase activity
E5Y90_09355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5Y90_09365	COG2234	aminopeptidase activity
E5Y90_09370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E5Y90_09375	COG3384	dioxygenase
E5Y90_09385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5Y90_09390	COG2878	Part of a membrane complex involved in electron transport
E5Y90_09395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5Y90_09420	COG0768	penicillin binding
E5Y90_09425	COG0742	ribosomal rna small subunit methyltransferase
E5Y90_09440	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_09450	COG0204	Acyl-transferase
E5Y90_09480	COG1597	lipid kinase activity
E5Y90_09505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5Y90_09505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5Y90_09520	COG0589	response to stress
E5Y90_09540	COG2321	neutral zinc metallopeptidase
E5Y90_09545	COG2354	Protein conserved in bacteria
E5Y90_09565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5Y90_09570	COG1773	rubredoxin
E5Y90_09575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5Y90_09585	COG0583	DNA-binding transcription factor activity
E5Y90_09605	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E5Y90_09610	COG4181	ATPase activity
E5Y90_09650	COG0306	phosphate transporter
E5Y90_09660	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_09670	COG0525	valine-tRNA ligase activity
E5Y90_09705	COG2323	membrane
E5Y90_09725	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5Y90_09740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5Y90_09745	COG0142	geranyltranstransferase activity
E5Y90_09750	COG2828	Protein conserved in bacteria
E5Y90_09760	COG2171	N-acyltransferase activity
E5Y90_09765	COG0602	queuosine metabolic process
E5Y90_09770	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E5Y90_09780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5Y90_09795	COG2353	YceI-like domain
E5Y90_09800	COG1051	belongs to the nudix hydrolase family
E5Y90_09800	COG1056	cytidyltransferase-related domain
E5Y90_09810	COG0778	Nitroreductase
E5Y90_09820	COG0047	phosphoribosylformylglycinamidine synthase activity
E5Y90_09820	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5Y90_09840	COG2255	four-way junction helicase activity
E5Y90_09845	COG0824	Thioesterase
E5Y90_09865	COG0823	Involved in the tonB-independent uptake of proteins
E5Y90_09885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5Y90_09915	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5Y90_09920	COG0628	permease
E5Y90_09930	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5Y90_09945	COG1560	Kdo2-lipid A biosynthetic process
E5Y90_09950	COG2333	competence protein COMEC
E5Y90_09950	COG0658	competence protein
E5Y90_09955	COG1136	(ABC) transporter
E5Y90_09975	COG1671	Belongs to the UPF0178 family
E5Y90_10010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5Y90_10060	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E5Y90_10065	COG0596	Alpha beta hydrolase
E5Y90_10085	COG1113	amino acid transport
E5Y90_10090	COG1115	amino acid carrier protein
E5Y90_10105	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E5Y90_10110	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E5Y90_10115	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E5Y90_10120	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5Y90_10125	COG5001	Diguanylate cyclase
E5Y90_10125	COG1716	ATPase activity
E5Y90_10140	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E5Y90_10150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5Y90_10155	COG2814	Major facilitator Superfamily
E5Y90_10160	COG1960	acyl-CoA dehydrogenase activity
E5Y90_10165	COG0583	DNA-binding transcription factor activity
E5Y90_10180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5Y90_10195	COG0037	tRNA processing
E5Y90_10200	COG0741	lytic transglycosylase activity
E5Y90_10200	COG0739	heme binding
E5Y90_10200	COG1196	nuclear chromosome segregation
E5Y90_10205	COG0501	Belongs to the peptidase M48B family
E5Y90_10215	COG2239	Acts as a magnesium transporter
E5Y90_10235	COG1253	flavin adenine dinucleotide binding
E5Y90_10270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5Y90_10280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5Y90_10285	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E5Y90_10305	COG0505	Belongs to the CarA family
E5Y90_10310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5Y90_10320	COG0415	Belongs to the DNA photolyase family
E5Y90_10325	COG0110	maltose O-acetyltransferase activity
E5Y90_10345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5Y90_10370	COG0564	pseudouridine synthase activity
E5Y90_10380	COG0358	DNA primase activity
E5Y90_10395	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E5Y90_10425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5Y90_10430	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E5Y90_10475	COG0586	Pfam SNARE associated Golgi protein
E5Y90_10500	COG2921	Belongs to the UPF0250 family
E5Y90_10505	COG0321	lipoyl(octanoyl) transferase activity
E5Y90_10520	COG0531	amino acid
E5Y90_10530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E5Y90_10535	COG1648	precorrin-2 dehydrogenase activity
E5Y90_10535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5Y90_10540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5Y90_10555	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E5Y90_10565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5Y90_10580	COG0671	phosphoesterase, PA-phosphatase related
E5Y90_10585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5Y90_10595	COG1538	Outer membrane efflux protein
E5Y90_10600	COG0393	Putative heavy-metal-binding
E5Y90_10605	COG0393	Putative heavy-metal-binding
E5Y90_10660	COG4681	YaeQ
E5Y90_10665	COG0523	cobalamin synthesis protein
E5Y90_10680	COG0583	DNA-binding transcription factor activity
E5Y90_10685	COG2814	Major facilitator Superfamily
E5Y90_10695	COG1607	acyl-coa hydrolase
E5Y90_10705	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5Y90_10715	COG0786	glutamate:sodium symporter activity
E5Y90_10725	COG2814	Major facilitator Superfamily
E5Y90_10730	COG1289	transmembrane transporter activity
E5Y90_10740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E5Y90_10800	COG2832	Protein of unknown function (DUF454)
E5Y90_10825	COG0643	Histidine kinase
E5Y90_10825	COG2198	Histidine kinase
E5Y90_10825	COG0784	Response regulator, receiver
E5Y90_10830	COG0840	transmembrane signaling receptor activity
E5Y90_10855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5Y90_10900	COG2358	TRAP transporter, solute receptor (TAXI family
E5Y90_10915	COG0489	protein tyrosine kinase activity
E5Y90_10925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5Y90_10925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5Y90_10945	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E5Y90_10950	COG2081	HI0933 family
E5Y90_10960	COG0668	transmembrane transport
E5Y90_10980	COG0583	DNA-binding transcription factor activity
E5Y90_10985	COG1278	Cold shock
E5Y90_11000	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E5Y90_11010	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5Y90_11015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5Y90_11020	COG0713	ATP synthesis coupled electron transport
E5Y90_11025	COG0839	Belongs to the complex I subunit 6 family
E5Y90_11030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5Y90_11045	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E5Y90_11065	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5Y90_11075	COG2205	protein histidine kinase activity
E5Y90_11080	COG0745	RESPONSE REGULATOR receiver
E5Y90_11085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5Y90_11085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5Y90_11090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5Y90_11135	COG0351	phosphomethylpyrimidine kinase
E5Y90_11135	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E5Y90_11135	COG0352	thiamine-phosphate diphosphorylase activity
E5Y90_11140	COG2824	Alkylphosphonate utilization operon protein PhnA
E5Y90_11155	COG0564	pseudouridine synthase activity
E5Y90_11185	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_11195	COG2610	gluconate transmembrane transporter activity
E5Y90_11205	COG0354	folic acid binding
E5Y90_11215	COG0679	Auxin Efflux Carrier
E5Y90_11220	COG1902	pentaerythritol trinitrate reductase activity
E5Y90_11230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5Y90_11235	COG1970	mechanosensitive ion channel activity
E5Y90_11245	COG2233	PERMEase
E5Y90_11255	COG0833	amino acid
E5Y90_11275	COG0183	Belongs to the thiolase family
E5Y90_11290	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5Y90_11300	COG2207	Transcriptional regulator
E5Y90_11305	COG0183	Belongs to the thiolase family
E5Y90_11310	COG1024	Enoyl-CoA hydratase
E5Y90_11310	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5Y90_11330	COG1272	protein, Hemolysin III
E5Y90_11335	COG0477	Major facilitator Superfamily
E5Y90_11345	COG1408	metallophosphoesterase
E5Y90_11350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5Y90_11360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5Y90_11385	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5Y90_11390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5Y90_11395	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E5Y90_11405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5Y90_11410	COG0625	glutathione transferase activity
E5Y90_11415	COG2969	positive regulation of protein catabolic process
E5Y90_11455	COG2199	diguanylate cyclase activity
E5Y90_11460	COG2885	chlorophyll binding
E5Y90_11490	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5Y90_11495	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E5Y90_11510	COG0450	alkyl hydroperoxide reductase
E5Y90_11525	COG0285	dihydrofolate synthase activity
E5Y90_11530	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E5Y90_11575	COG0037	tRNA processing
E5Y90_11585	COG0248	Ppx GppA phosphatase
E5Y90_11610	COG0072	phenylalanine-tRNA ligase activity
E5Y90_11615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E5Y90_11650	COG1238	metal cluster binding
E5Y90_11660	COG0625	glutathione transferase activity
E5Y90_11670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E5Y90_11690	COG0318	PFAM AMP-dependent synthetase and ligase
E5Y90_11705	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E5Y90_11715	COG1704	LemA family
E5Y90_11725	COG1862	Preprotein translocase
E5Y90_11735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5Y90_11750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5Y90_11770	COG2205	protein histidine kinase activity
E5Y90_11770	COG0784	Response regulator, receiver
E5Y90_11770	COG5002	protein histidine kinase activity
E5Y90_11780	COG2084	Dehydrogenase
E5Y90_11785	COG3622	Belongs to the hyi family
E5Y90_11815	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E5Y90_11820	COG1960	acyl-CoA dehydrogenase activity
E5Y90_11825	COG2072	flavoprotein involved in K transport
E5Y90_11830	COG0203	ribosomal protein L17
E5Y90_11840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5Y90_11875	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5Y90_11885	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5Y90_11890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5Y90_11895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5Y90_11925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5Y90_11940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E5Y90_11950	COG0089	rRNA binding
E5Y90_11955	COG0088	Forms part of the polypeptide exit tunnel
E5Y90_11960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E5Y90_11985	COG1959	2 iron, 2 sulfur cluster binding
E5Y90_12005	COG1301	dicarboxylic acid transport
E5Y90_12010	COG1946	Acyl-CoA thioesterase
E5Y90_12015	COG2937	Belongs to the GPAT DAPAT family
E5Y90_12025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5Y90_12030	COG1040	competence protein
E5Y90_12035	COG0494	nUDIX hydrolase
E5Y90_12045	COG0598	Magnesium transport protein CorA
E5Y90_12055	COG2854	intermembrane phospholipid transfer
E5Y90_12060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E5Y90_12065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E5Y90_12070	COG1127	ABC transporter
E5Y90_12085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5Y90_12095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5Y90_12100	COG0408	coproporphyrinogen oxidase activity
E5Y90_12115	COG1960	acyl-CoA dehydrogenase activity
E5Y90_12125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5Y90_12135	COG0534	Mate efflux family protein
E5Y90_12145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5Y90_12150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5Y90_12180	COG1192	Involved in chromosome partitioning
E5Y90_12185	COG0628	permease
E5Y90_12195	COG2814	Major facilitator Superfamily
E5Y90_12215	COG0277	FAD linked oxidase domain protein
E5Y90_12220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5Y90_12230	COG5006	permease, DMT superfamily
E5Y90_12245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5Y90_12250	COG5380	lipid catabolic process
E5Y90_12255	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E5Y90_12270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5Y90_12275	COG0228	four-way junction DNA binding
E5Y90_12320	COG0194	GDP metabolic process
E5Y90_12325	COG1758	RNA polymerase activity
E5Y90_12330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5Y90_12350	COG3307	-O-antigen
E5Y90_12355	COG3307	-O-antigen
E5Y90_12445	COG1704	LemA family
E5Y90_12455	COG0493	'glutamate synthase
E5Y90_12460	COG0067	glutamate synthase
E5Y90_12460	COG0069	glutamate synthase activity
E5Y90_12460	COG0070	glutamate synthase
E5Y90_12510	COG2226	methyltransferase
E5Y90_12515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5Y90_12520	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5Y90_12525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5Y90_12545	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E5Y90_12575	COG0488	(ABC) transporter
E5Y90_12585	COG4221	oxidoreductase activity
E5Y90_12590	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5Y90_12600	COG2111	Na H antiporter
E5Y90_12600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5Y90_12605	COG1006	Multisubunit Na H antiporter MnhC subunit
E5Y90_12610	COG0651	ATP synthesis coupled electron transport
E5Y90_12615	COG1863	multisubunit Na H antiporter MnhE subunit
E5Y90_12620	COG2212	antiporter activity
E5Y90_12630	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5Y90_12640	COG0195	Participates in both transcription termination and antitermination
E5Y90_12680	COG0149	triose-phosphate isomerase activity
E5Y90_12700	COG0237	dephospho-CoA kinase activity
E5Y90_12710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5Y90_12715	COG3123	guanosine phosphorylase activity
E5Y90_12720	COG0497	DNA recombination
E5Y90_12730	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E5Y90_12740	COG1132	(ABC) transporter
E5Y90_12760	COG1538	Outer membrane efflux protein
E5Y90_12775	COG0494	nUDIX hydrolase
E5Y90_12785	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E5Y90_12790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5Y90_12800	COG0772	Belongs to the SEDS family
E5Y90_12825	COG4974	Belongs to the 'phage' integrase family
E5Y90_12830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5Y90_12840	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5Y90_12850	COG2197	response regulator
E5Y90_12855	COG4191	Histidine kinase
E5Y90_12865	COG0793	Belongs to the peptidase S41A family
E5Y90_12870	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E5Y90_12875	COG0795	lipopolysaccharide-transporting ATPase activity
E5Y90_12880	COG0795	lipopolysaccharide-transporting ATPase activity
E5Y90_12900	COG0586	Pfam SNARE associated Golgi protein
E5Y90_12915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5Y90_12915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5Y90_12925	COG0004	ammonium transporteR
E5Y90_12930	COG0347	Belongs to the P(II) protein family
E5Y90_12940	COG0606	chelatase, subunit chli
E5Y90_12955	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E5Y90_12970	COG0318	PFAM AMP-dependent synthetase and ligase
E5Y90_12980	COG0477	Major facilitator Superfamily
E5Y90_12985	COG2860	membrane
E5Y90_12995	COG1253	flavin adenine dinucleotide binding
E5Y90_13010	COG0477	Major facilitator Superfamily
E5Y90_13020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5Y90_13040	COG2814	Major facilitator Superfamily
E5Y90_13090	COG0758	DNA mediated transformation
E5Y90_13100	COG0697	spore germination
E5Y90_13115	COG0386	Belongs to the glutathione peroxidase family
E5Y90_13140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5Y90_13190	COG1121	(ABC) transporter
E5Y90_13195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5Y90_13200	COG1683	Conserved Protein
E5Y90_13215	COG2837	iron assimilation
E5Y90_13225	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
E5Y90_13270	COG0629	single-stranded DNA binding
E5Y90_13275	COG2814	Major facilitator Superfamily
E5Y90_13285	COG0351	phosphomethylpyrimidine kinase
E5Y90_13285	COG0352	thiamine-phosphate diphosphorylase activity
E5Y90_13285	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E5Y90_13295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5Y90_13310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5Y90_13320	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5Y90_13325	COG3162	membrane
E5Y90_13330	COG2205	protein histidine kinase activity
E5Y90_13330	COG0784	Response regulator, receiver
E5Y90_13345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5Y90_13355	COG0668	transmembrane transport
E5Y90_13360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5Y90_13365	COG1519	Transferase
E5Y90_13370	COG1902	pentaerythritol trinitrate reductase activity
E5Y90_13400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5Y90_13425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5Y90_13425	COG0426	domain, Protein
E5Y90_13430	COG2119	membrane
E5Y90_13445	COG4942	peptidase
E5Y90_13470	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5Y90_13480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5Y90_13490	COG0189	ligase activity
E5Y90_13505	COG2132	Multicopper oxidase
E5Y90_13530	COG4689	acetoacetate decarboxylase
E5Y90_13535	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5Y90_13535	COG1902	pentaerythritol trinitrate reductase activity
E5Y90_13545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5Y90_13550	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5Y90_13565	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5Y90_13575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5Y90_13585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5Y90_13590	COG0438	transferase activity, transferring glycosyl groups
E5Y90_13605	COG0438	transferase activity, transferring glycosyl groups
E5Y90_13620	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E5Y90_13665	COG1194	a g-specific adenine glycosylase
E5Y90_13670	COG0739	heme binding
E5Y90_13695	COG2818	Glycosylase
E5Y90_13700	COG1064	alcohol dehydrogenase
E5Y90_13710	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E5Y90_13755	COG0560	Phosphoserine phosphatase
E5Y90_13755	COG3830	Belongs to the UPF0237 family
E5Y90_13765	COG0385	Bile acid
E5Y90_13770	COG1335	isochorismatase
E5Y90_13775	COG2814	Major facilitator Superfamily
E5Y90_13780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5Y90_13790	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5Y90_13795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5Y90_13805	COG2983	Belongs to the UPF0260 family
E5Y90_13810	COG5487	UPF0391 membrane protein
E5Y90_13820	COG3023	N-Acetylmuramoyl-L-alanine amidase
E5Y90_13835	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E5Y90_13840	COG1309	transcriptional regulator
E5Y90_13845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5Y90_13850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5Y90_13855	COG0546	phosphoglycolate phosphatase activity
E5Y90_13860	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_13880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5Y90_13880	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E5Y90_13885	COG1309	transcriptional regulator
E5Y90_13895	COG0196	riboflavin kinase activity
E5Y90_13900	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5Y90_13910	COG1047	Peptidyl-prolyl cis-trans
E5Y90_13920	COG2133	pyrroloquinoline quinone binding
E5Y90_13950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5Y90_13955	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E5Y90_13960	COG2951	lytic endotransglycosylase activity
E5Y90_13965	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5Y90_13980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5Y90_13990	COG2814	Major facilitator Superfamily
E5Y90_13995	COG0861	Integral membrane protein TerC family
E5Y90_14000	COG0402	S-adenosylhomocysteine deaminase activity
E5Y90_14015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5Y90_14030	COG0706	membrane insertase activity
E5Y90_14035	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E5Y90_14040	COG0594	ribonuclease P activity
E5Y90_14070	COG1024	Enoyl-CoA hydratase
E5Y90_14085	COG0318	PFAM AMP-dependent synthetase and ligase
E5Y90_14410	COG0629	single-stranded DNA binding
E5Y90_14445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5Y90_14640	COG1309	transcriptional regulator
E5Y90_14995	COG3550	peptidyl-serine autophosphorylation
E5Y90_15275	COG0739	heme binding
E5Y90_15460	COG0501	Belongs to the peptidase M48B family
E5Y90_15475	COG1309	transcriptional regulator
E5Y90_15495	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_15645	COG5265	(ABC) transporter
E5Y90_15690	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E5Y90_15715	COG0754	glutathionylspermidine amidase activity
E5Y90_15805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5Y90_15815	COG1525	nuclease
E5Y90_15945	COG1484	DNA-dependent DNA replication
E5Y90_16000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5Y90_16010	COG2610	gluconate transmembrane transporter activity
E5Y90_16015	COG1454	alcohol dehydrogenase
E5Y90_16025	COG1414	Transcriptional regulator
E5Y90_16075	COG1373	ATPase (AAA superfamily
E5Y90_16145	COG1012	belongs to the aldehyde dehydrogenase family
E5Y90_16165	COG3077	Addiction module antitoxin, RelB DinJ family
E5Y90_16190	COG1414	Transcriptional regulator
E5Y90_16225	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
E5Y90_16295	COG2801	Transposase and inactivated derivatives
E5Y90_16345	COG2801	Transposase and inactivated derivatives
E5Y90_16370	COG4680	protein conserved in bacteria
E5Y90_16400	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5Y90_16435	COG0789	Transcriptional regulator
E5Y90_16460	COG0582	viral genome integration into host DNA
E5Y90_16465	COG2369	cell adhesion
E5Y90_16490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5Y90_16550	COG4372	Transposase
E5Y90_16610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5Y90_16670	COG2963	transposase activity
E5Y90_16675	COG1475	DNA binding
E5Y90_16680	COG1192	Involved in chromosome partitioning
E5Y90_16695	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5Y90_16790	COG2184	nucleotidyltransferase activity
E5Y90_16820	COG1475	DNA binding
E5Y90_16825	COG1192	Involved in chromosome partitioning
E5Y90_16870	COG0745	RESPONSE REGULATOR receiver
E5Y90_16875	COG5002	protein histidine kinase activity
E5Y90_16885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5Y90_16940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5Y90_16985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5Y90_17005	COG1335	isochorismatase
E5Y90_17010	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5Y90_17030	COG0753	catalase activity
E5Y90_17040	COG0753	catalase activity
E5Y90_17100	COG0583	DNA-binding transcription factor activity
E5Y90_17120	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E5Y90_17125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5Y90_17135	COG0659	secondary active sulfate transmembrane transporter activity
E5Y90_17190	COG2944	sequence-specific DNA binding
E5Y90_17250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5Y90_17290	COG2076	Multidrug Resistance protein
E5Y90_17300	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
E5Y90_17325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD