locus-tag	class	description
G8E00_00015	COG0594	ribonuclease P activity
G8E00_00020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G8E00_00025	COG0706	membrane insertase activity
G8E00_00050	COG1230	cation diffusion facilitator family transporter
G8E00_00055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G8E00_00060	COG2261	transglycosylase associated protein
G8E00_00070	COG0402	S-adenosylhomocysteine deaminase activity
G8E00_00090	COG0754	glutathionylspermidine amidase activity
G8E00_00110	COG0861	Integral membrane protein TerC family
G8E00_00120	COG2388	GCN5-related N-acetyl-transferase
G8E00_00130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G8E00_00150	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G8E00_00155	COG2951	lytic endotransglycosylase activity
G8E00_00205	COG1012	belongs to the aldehyde dehydrogenase family
G8E00_00210	COG3738	Protein conserved in bacteria
G8E00_00215	COG0733	neurotransmitter:sodium symporter activity
G8E00_00225	COG0428	transporter
G8E00_00320	COG0129	dihydroxy-acid dehydratase activity
G8E00_00335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G8E00_00345	COG0583	DNA-binding transcription factor activity
G8E00_00350	COG2233	PERMEase
G8E00_00355	COG3706	GGDEF domain
G8E00_00370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8E00_00395	COG1028	Short-chain dehydrogenase reductase Sdr
G8E00_00400	COG0546	phosphoglycolate phosphatase activity
G8E00_00405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G8E00_00420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G8E00_00420	COG1017	nitric oxide dioxygenase activity
G8E00_00445	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G8E00_00455	COG1368	sulfuric ester hydrolase activity
G8E00_00465	COG3023	N-Acetylmuramoyl-L-alanine amidase
G8E00_00470	COG0728	peptidoglycan biosynthetic process
G8E00_00495	COG1596	polysaccharide export
G8E00_00500	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G8E00_00520	COG0438	transferase activity, transferring glycosyl groups
G8E00_00540	COG1215	transferase activity, transferring glycosyl groups
G8E00_00555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G8E00_00570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G8E00_00575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8E00_00630	COG0271	Belongs to the BolA IbaG family
G8E00_00640	COG1192	Involved in chromosome partitioning
G8E00_00655	COG0586	Pfam SNARE associated Golgi protein
G8E00_00665	COG0519	Catalyzes the synthesis of GMP from XMP
G8E00_00665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G8E00_00670	COG1715	Restriction endonuclease
G8E00_00675	COG3706	GGDEF domain
G8E00_00745	COG4266	Belongs to the allantoicase family
G8E00_00750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G8E00_00765	COG2233	PERMEase
G8E00_00770	COG2351	hydroxyisourate hydrolase activity
G8E00_00815	COG1393	Belongs to the ArsC family
G8E00_00820	COG0708	Exodeoxyribonuclease III
G8E00_00830	COG0456	acetyltransferase
G8E00_00850	COG2720	vancomycin resistance protein
G8E00_00855	COG2226	methyltransferase
G8E00_00860	COG0189	ligase activity
G8E00_00880	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G8E00_00910	COG4942	peptidase
G8E00_00930	COG2119	membrane
G8E00_00935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G8E00_00935	COG0426	domain, Protein
G8E00_00960	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G8E00_01025	COG1902	pentaerythritol trinitrate reductase activity
G8E00_01030	COG1519	Transferase
G8E00_01035	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G8E00_01040	COG0668	transmembrane transport
G8E00_01045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G8E00_01070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8E00_01090	COG0784	Response regulator, receiver
G8E00_01090	COG2205	protein histidine kinase activity
G8E00_01095	COG3162	membrane
G8E00_01120	COG3706	GGDEF domain
G8E00_01135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G8E00_01145	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G8E00_01155	COG2814	Major facilitator Superfamily
G8E00_01160	COG0629	single-stranded DNA binding
G8E00_01210	COG0778	Nitroreductase
G8E00_01220	COG1733	regulation of RNA biosynthetic process
G8E00_01235	COG1335	isochorismatase
G8E00_01245	COG0493	'glutamate synthase
G8E00_01270	COG3158	transport of potassium into the cell
G8E00_01295	COG2207	Transcriptional regulator
G8E00_01300	COG0107	imidazoleglycerol-phosphate synthase activity
G8E00_01305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G8E00_01310	COG1278	Cold shock
G8E00_01320	COG2329	Antibiotic biosynthesis monooxygenase
G8E00_01355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G8E00_01395	COG0427	acetyl-CoA hydrolase
G8E00_01400	COG2205	protein histidine kinase activity
G8E00_01405	COG0745	RESPONSE REGULATOR receiver
G8E00_01435	COG0659	secondary active sulfate transmembrane transporter activity
G8E00_01450	COG0583	DNA-binding transcription factor activity
G8E00_01455	COG4221	oxidoreductase activity
G8E00_01460	COG2873	o-acetylhomoserine
G8E00_01465	COG0488	(ABC) transporter
G8E00_01510	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G8E00_01540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G8E00_01545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G8E00_01555	COG2226	methyltransferase
G8E00_01605	COG0069	glutamate synthase activity
G8E00_01605	COG0070	glutamate synthase
G8E00_01605	COG0067	glutamate synthase
G8E00_01610	COG0493	'glutamate synthase
G8E00_01620	COG0307	riboflavin synthase, alpha
G8E00_01630	COG2212	antiporter activity
G8E00_01640	COG0651	ATP synthesis coupled electron transport
G8E00_01645	COG1006	Multisubunit Na H antiporter MnhC subunit
G8E00_01650	COG2111	Na H antiporter
G8E00_01650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G8E00_01655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G8E00_01665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G8E00_01680	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G8E00_01710	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
G8E00_01715	COG1074	ATP-dependent DNA helicase activity
G8E00_01720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G8E00_01735	COG1185	polyribonucleotide nucleotidyltransferase activity
G8E00_01740	COG0598	Magnesium transport protein CorA
G8E00_01745	COG2841	Protein conserved in bacteria
G8E00_01760	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G8E00_01770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G8E00_01790	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G8E00_01795	COG4535	Mg2 and Co2 transporter CorC
G8E00_01810	COG3501	Rhs element vgr protein
G8E00_01835	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
G8E00_01835	COG0644	oxidoreductase
G8E00_01845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G8E00_01860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G8E00_01865	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
G8E00_01875	COG0493	'glutamate synthase
G8E00_01890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G8E00_01895	COG0254	rRNA binding
G8E00_01900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G8E00_01905	COG0534	Mate efflux family protein
G8E00_01915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G8E00_01920	COG2194	sulfuric ester hydrolase activity
G8E00_01925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G8E00_01935	COG1960	acyl-CoA dehydrogenase activity
G8E00_01950	COG0408	coproporphyrinogen oxidase activity
G8E00_01955	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G8E00_01970	COG0513	Belongs to the DEAD box helicase family
G8E00_01975	COG1127	ABC transporter
G8E00_01980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G8E00_01985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G8E00_01990	COG2854	intermembrane phospholipid transfer
G8E00_02000	COG0598	Magnesium transport protein CorA
G8E00_02010	COG0494	nUDIX hydrolase
G8E00_02015	COG1040	competence protein
G8E00_02020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G8E00_02040	COG2937	Belongs to the GPAT DAPAT family
G8E00_02045	COG1946	Acyl-CoA thioesterase
G8E00_02055	COG1301	dicarboxylic acid transport
G8E00_02070	COG4993	Dehydrogenase
G8E00_02075	COG1959	2 iron, 2 sulfur cluster binding
G8E00_02080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G8E00_02080	COG1017	nitric oxide dioxygenase activity
G8E00_02085	COG0433	COG0433 Predicted ATPase
G8E00_02090	COG0626	cystathionine gamma-synthase activity
G8E00_02100	COG0051	transcription antitermination factor activity, RNA binding
G8E00_02105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G8E00_02110	COG0088	Forms part of the polypeptide exit tunnel
G8E00_02125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G8E00_02155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G8E00_02175	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G8E00_02180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G8E00_02190	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G8E00_02225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G8E00_02230	COG0202	RNA polymerase activity
G8E00_02235	COG0203	ribosomal protein L17
G8E00_02240	COG2072	flavoprotein involved in K transport
G8E00_02245	COG3971	2-oxopent-4-enoate hydratase activity
G8E00_02250	COG4569	acetaldehyde dehydrogenase (acetylating) activity
G8E00_02270	COG0583	DNA-binding transcription factor activity
G8E00_02275	COG4638	Rieske (2fe-2S)
G8E00_02290	COG1028	Short-chain dehydrogenase reductase Sdr
G8E00_02295	COG3384	dioxygenase
G8E00_02300	COG0446	pyridine nucleotide-disulphide oxidoreductase
G8E00_02340	COG1960	acyl-CoA dehydrogenase activity
G8E00_02345	COG0300	oxidoreductase activity
G8E00_02370	COG0494	nUDIX hydrolase
G8E00_02385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G8E00_02415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G8E00_02435	COG0473	3-isopropylmalate dehydrogenase activity
G8E00_02460	COG0252	asparaginase activity
G8E00_02500	COG1560	Kdo2-lipid A biosynthetic process
G8E00_02505	COG3594	Acyltransferase
G8E00_02530	COG0804	urea catabolic process
G8E00_02545	COG0494	nUDIX hydrolase
G8E00_02565	COG0830	nickel cation binding
G8E00_02585	COG2900	Belongs to the SlyX family
G8E00_02595	COG1028	Short-chain dehydrogenase reductase Sdr
G8E00_02600	COG1733	regulation of RNA biosynthetic process
G8E00_02625	COG1929	Belongs to the glycerate kinase type-1 family
G8E00_02635	COG0210	DNA helicase
G8E00_02670	COG4651	solute:proton antiporter activity
G8E00_02670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G8E00_02695	COG0788	formyltetrahydrofolate deformylase activity
G8E00_02805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G8E00_02805	COG2813	Specifically methylates the guanine in position
G8E00_02810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G8E00_02815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G8E00_02830	COG4774	siderophore transport
G8E00_02835	COG4774	siderophore transport
G8E00_02845	COG0740	serine-type endopeptidase activity
G8E00_02865	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G8E00_02865	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
G8E00_02875	COG0280	phosphate acetyltransferase
G8E00_02875	COG0857	belongs to the CobB CobQ family
G8E00_02880	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G8E00_02905	COG0793	Belongs to the peptidase S41A family
G8E00_02915	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G8E00_02930	COG0084	hydrolase, TatD family'
G8E00_02945	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G8E00_02955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G8E00_03040	COG2814	Major facilitator Superfamily
G8E00_03075	COG0583	DNA-binding transcription factor activity
G8E00_03080	COG1053	succinate dehydrogenase
G8E00_03095	COG0004	ammonium transporteR
G8E00_03110	COG3622	Belongs to the hyi family
G8E00_03115	COG2084	Dehydrogenase
G8E00_03120	COG1024	Enoyl-CoA hydratase
G8E00_03125	COG0784	Response regulator, receiver
G8E00_03125	COG2205	protein histidine kinase activity
G8E00_03125	COG5002	protein histidine kinase activity
G8E00_03145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G8E00_03160	COG3956	TIGRFAM MazG family protein
G8E00_03165	COG1555	photosystem II stabilization
G8E00_03170	COG0617	tRNA 3'-terminal CCA addition
G8E00_03175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G8E00_03190	COG1660	Displays ATPase and GTPase activities
G8E00_03195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G8E00_03210	COG0318	PFAM AMP-dependent synthetase and ligase
G8E00_03225	COG0069	glutamate synthase activity
G8E00_03245	COG0625	glutathione transferase activity
G8E00_03250	COG1238	metal cluster binding
G8E00_03300	COG0072	phenylalanine-tRNA ligase activity
G8E00_03305	COG0776	regulation of translation
G8E00_03325	COG0248	Ppx GppA phosphatase
G8E00_03335	COG0037	tRNA processing
G8E00_03395	COG1764	response to oxidative stress
G8E00_03400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G8E00_03415	COG2853	Lipoprotein
G8E00_03450	COG1960	acyl-CoA dehydrogenase activity
G8E00_03455	COG1309	transcriptional regulator
G8E00_03470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G8E00_03475	COG1960	acyl-CoA dehydrogenase activity
G8E00_03480	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8E00_03480	COG1024	Enoyl-CoA hydratase
G8E00_03515	COG2969	positive regulation of protein catabolic process
G8E00_03520	COG0625	glutathione transferase activity
G8E00_03530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G8E00_03535	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G8E00_03540	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G8E00_03545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G8E00_03550	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G8E00_03575	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G8E00_03585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G8E00_03590	COG1408	metallophosphoesterase
G8E00_03595	COG0477	Major facilitator Superfamily
G8E00_03600	COG1272	protein, Hemolysin III
G8E00_03615	COG0456	acetyltransferase
G8E00_03620	COG1011	Hydrolase
G8E00_03630	COG1024	Enoyl-CoA hydratase
G8E00_03630	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8E00_03635	COG0183	Belongs to the thiolase family
G8E00_03645	COG2207	Transcriptional regulator
G8E00_03695	COG0285	dihydrofolate synthase activity
G8E00_03715	COG0450	alkyl hydroperoxide reductase
G8E00_03730	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G8E00_03735	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G8E00_03760	COG2885	chlorophyll binding
G8E00_03765	COG2199	diguanylate cyclase activity
G8E00_03800	COG2814	Major facilitator Superfamily
G8E00_03805	COG1126	abc transporter atp-binding protein
G8E00_03810	COG0765	amino acid transport
G8E00_03815	COG0765	amino acid transport
G8E00_03820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8E00_03845	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G8E00_03855	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G8E00_03905	COG0494	nUDIX hydrolase
G8E00_03920	COG1968	undecaprenyl-diphosphatase activity
G8E00_03935	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G8E00_03955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G8E00_03965	COG2132	Multicopper oxidase
G8E00_03970	COG3667	copper resistance
G8E00_03975	COG2076	Multidrug Resistance protein
G8E00_03995	COG0028	Belongs to the TPP enzyme family
G8E00_04000	COG0352	thiamine-phosphate diphosphorylase activity
G8E00_04000	COG0351	phosphomethylpyrimidine kinase
G8E00_04000	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G8E00_04025	COG0251	oxidation-reduction process
G8E00_04030	COG1113	amino acid transport
G8E00_04055	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G8E00_04080	COG0456	acetyltransferase
G8E00_04090	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G8E00_04095	COG0492	ferredoxin-NADP+ reductase activity
G8E00_04100	COG1674	ftsk spoiiie
G8E00_04100	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G8E00_04135	COG0204	Acyl-transferase
G8E00_04140	COG2885	chlorophyll binding
G8E00_04145	COG2885	chlorophyll binding
G8E00_04150	COG0210	DNA helicase
G8E00_04155	COG0756	dUTP diphosphatase activity
G8E00_04160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8E00_04165	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G8E00_04170	COG0121	glutamine amidotransferase
G8E00_04185	COG2914	Belongs to the UPF0125 (RnfH) family
G8E00_04190	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G8E00_04195	COG0735	belongs to the Fur family
G8E00_04230	COG0420	3'-5' exonuclease activity
G8E00_04250	COG2050	protein possibly involved in aromatic compounds catabolism
G8E00_04255	COG1566	PFAM secretion protein HlyD family protein
G8E00_04260	COG2814	Major facilitator Superfamily
G8E00_04265	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G8E00_04275	COG1401	restriction endodeoxyribonuclease activity
G8E00_04290	COG4771	TonB-dependent receptor
G8E00_04295	COG1429	ligase activity, forming nitrogen-metal bonds
G8E00_04325	COG4774	siderophore transport
G8E00_04380	COG3706	GGDEF domain
G8E00_04395	COG3706	GGDEF domain
G8E00_04400	COG0242	peptide deformylase activity
G8E00_04410	COG2066	Belongs to the glutaminase family
G8E00_04420	COG2376	Dihydroxyacetone kinase
G8E00_04445	COG0306	phosphate transporter
G8E00_04460	COG4607	ABC-type enterochelin transport system periplasmic component
G8E00_04475	COG4771	TonB-dependent receptor
G8E00_04500	COG4181	ATPase activity
G8E00_04505	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G8E00_04525	COG0583	DNA-binding transcription factor activity
G8E00_04530	COG2267	carboxylic ester hydrolase activity
G8E00_04535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G8E00_04540	COG1773	rubredoxin
G8E00_04545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G8E00_04575	COG0175	sulfate reduction
G8E00_04595	COG1028	Short-chain dehydrogenase reductase Sdr
G8E00_04625	COG3338	carbonate dehydratase activity
G8E00_04660	COG0525	valine-tRNA ligase activity
G8E00_04670	COG1028	Short-chain dehydrogenase reductase Sdr
G8E00_04680	COG0393	Putative heavy-metal-binding
G8E00_04685	COG0393	Putative heavy-metal-binding
G8E00_04700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8E00_04705	COG0671	phosphoesterase, PA-phosphatase related
G8E00_04720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G8E00_04730	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G8E00_04740	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G8E00_04745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G8E00_04745	COG1648	precorrin-2 dehydrogenase activity
G8E00_04750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G8E00_04760	COG0531	amino acid
G8E00_04775	COG0321	lipoyl(octanoyl) transferase activity
G8E00_04795	COG2921	Belongs to the UPF0250 family
G8E00_04800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G8E00_04860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G8E00_04890	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
G8E00_04905	COG0358	DNA primase activity
G8E00_04915	COG0564	pseudouridine synthase activity
G8E00_04930	COG3293	Transposase
G8E00_04940	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G8E00_04950	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G8E00_04985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G8E00_04985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G8E00_04995	COG0714	Associated with various cellular activities
G8E00_05000	COG2425	protein containing a von Willebrand factor type A (vWA) domain
G8E00_05015	COG0300	oxidoreductase activity
G8E00_05020	COG2072	flavoprotein involved in K transport
G8E00_05035	COG2009	succinate dehydrogenase
G8E00_05040	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G8E00_05045	COG1053	succinate dehydrogenase
G8E00_05050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G8E00_05065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G8E00_05075	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G8E00_05085	COG0742	ribosomal rna small subunit methyltransferase
G8E00_05090	COG0768	penicillin binding
G8E00_05115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G8E00_05120	COG2878	Part of a membrane complex involved in electron transport
G8E00_05125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G8E00_05135	COG3384	dioxygenase
G8E00_05145	COG2234	aminopeptidase activity
G8E00_05155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G8E00_05165	COG2217	Heavy metal translocating P-type atpase
G8E00_05180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G8E00_05185	COG0022	dehydrogenase e1 component
G8E00_05190	COG0508	dehydrogenase complex catalyzes the overall conversion of
G8E00_05195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G8E00_05210	COG0640	Transcriptional regulator
G8E00_05280	COG0281	malic enzyme
G8E00_05280	COG0280	phosphate acetyltransferase
G8E00_05290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G8E00_05295	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G8E00_05300	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G8E00_05330	COG0583	DNA-binding transcription factor activity
G8E00_05335	COG0596	Alpha beta hydrolase
G8E00_05340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8E00_05345	COG1335	isochorismatase
G8E00_05350	COG0251	oxidation-reduction process
G8E00_05355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G8E00_05360	COG2233	PERMEase
G8E00_05375	COG0183	Belongs to the thiolase family
G8E00_05410	COG0833	amino acid
G8E00_05425	COG0833	amino acid
G8E00_05430	COG1671	Belongs to the UPF0178 family
G8E00_05450	COG1136	(ABC) transporter
G8E00_05480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G8E00_05485	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G8E00_05490	COG0628	permease
G8E00_05535	COG3634	alkyl hydroperoxide reductase activity
G8E00_05540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G8E00_05550	COG0640	Transcriptional regulator
G8E00_05555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G8E00_05560	COG0798	PFAM Bile acid sodium symporter
G8E00_05565	COG0431	NADPH-dependent FMN reductase
G8E00_05590	COG1720	tRNA m6t6A37 methyltransferase activity
G8E00_05600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G8E00_05620	COG0642	Histidine kinase
G8E00_05640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8E00_05645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G8E00_05650	COG3139	Protein of unknown function (DUF1315)
G8E00_05655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G8E00_05680	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
G8E00_05685	COG1960	acyl-CoA dehydrogenase activity
G8E00_05700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G8E00_05715	COG1522	sequence-specific DNA binding
G8E00_05750	COG3209	COG3209 Rhs family protein
G8E00_05775	COG0415	Belongs to the DNA photolyase family
G8E00_05785	COG1252	NADH dehydrogenase
G8E00_05790	COG2885	chlorophyll binding
G8E00_05795	COG1686	Belongs to the peptidase S11 family
G8E00_05810	COG2351	hydroxyisourate hydrolase activity
G8E00_05840	COG0612	Peptidase, M16
G8E00_05870	COG1309	transcriptional regulator
G8E00_05875	COG1132	(ABC) transporter
G8E00_05900	COG0352	thiamine-phosphate diphosphorylase activity
G8E00_05940	COG1022	Amp-dependent synthetase and ligase
G8E00_05950	COG0583	DNA-binding transcription factor activity
G8E00_05955	COG1309	transcriptional regulator
G8E00_05975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G8E00_05980	COG0076	glutamate decarboxylase activity
G8E00_06000	COG0573	inorganic phosphate transmembrane transporter activity
G8E00_06010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G8E00_06015	COG0765	amino acid transport
G8E00_06025	COG1126	abc transporter atp-binding protein
G8E00_06030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8E00_06035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8E00_06040	COG2234	aminopeptidase activity
G8E00_06040	COG4935	Belongs to the peptidase S8 family
G8E00_06045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G8E00_06045	COG0047	phosphoribosylformylglycinamidine synthase activity
G8E00_06065	COG0583	DNA-binding transcription factor activity
G8E00_06070	COG3323	Protein of unknown function (DUF1653)
G8E00_06070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G8E00_06075	COG0778	Nitroreductase
G8E00_06080	COG1024	Enoyl-CoA hydratase
G8E00_06085	COG1051	belongs to the nudix hydrolase family
G8E00_06085	COG1056	cytidyltransferase-related domain
G8E00_06090	COG0583	DNA-binding transcription factor activity
G8E00_06100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G8E00_06110	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G8E00_06115	COG0602	queuosine metabolic process
G8E00_06130	COG0583	DNA-binding transcription factor activity
G8E00_06135	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G8E00_06140	COG4208	sulfate ABC transporter
G8E00_06145	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
G8E00_06155	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G8E00_06160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G8E00_06165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G8E00_06185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G8E00_06215	COG0571	ribonuclease III activity
G8E00_06220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G8E00_06230	COG1381	Involved in DNA repair and RecF pathway recombination
G8E00_06235	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G8E00_06285	COG0436	Aminotransferase
G8E00_06310	COG0556	nucleotide-excision repair
G8E00_06315	COG3040	lipid binding
G8E00_06320	COG2962	Rard protein
G8E00_06345	COG0702	epimerase
G8E00_06350	COG1733	regulation of RNA biosynthetic process
G8E00_06360	COG1278	Cold shock
G8E00_06365	COG2814	Major facilitator Superfamily
G8E00_06405	COG2318	DinB family
G8E00_06470	COG1643	Atp-dependent helicase
G8E00_06555	COG0402	S-adenosylhomocysteine deaminase activity
G8E00_06560	COG4521	taurine ABC transporter
G8E00_06565	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G8E00_06570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8E00_06575	COG2175	clavaminate synthase activity
G8E00_06585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G8E00_06590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G8E00_06610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8E00_06610	COG1116	anion transmembrane transporter activity
G8E00_06620	COG2223	nitrite transmembrane transporter activity
G8E00_06625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G8E00_06630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G8E00_06635	COG0243	molybdopterin cofactor binding
G8E00_06645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G8E00_06655	COG0314	molybdopterin synthase activity
G8E00_06660	COG0315	cyclic pyranopterin monophosphate synthase activity
G8E00_06660	COG0521	Mo-molybdopterin cofactor biosynthetic process
G8E00_06665	COG0303	'Molybdopterin
G8E00_06670	COG0725	ABC transporter, periplasmic molybdate-binding protein
G8E00_06675	COG4149	molybdate abc transporter
G8E00_06680	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G8E00_06695	COG0517	IMP dehydrogenase activity
G8E00_06695	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
G8E00_06700	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G8E00_06710	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
G8E00_06715	COG1137	ATPase activity
G8E00_06725	COG1132	(ABC) transporter
G8E00_06750	COG4122	O-methyltransferase activity
G8E00_06760	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G8E00_06810	COG0436	Aminotransferase
G8E00_06815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G8E00_06820	COG0386	Belongs to the glutathione peroxidase family
G8E00_06830	COG2431	L-lysine efflux transmembrane transporter activity
G8E00_06840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G8E00_06845	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G8E00_06870	COG1253	flavin adenine dinucleotide binding
G8E00_06895	COG0024	Methionine aminopeptidase
G8E00_06900	COG3135	benzoate transporter
G8E00_06910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G8E00_06915	COG0583	DNA-binding transcription factor activity
G8E00_06930	COG0183	Belongs to the thiolase family
G8E00_06935	COG1028	Short-chain dehydrogenase reductase Sdr
G8E00_06960	COG0824	Thioesterase
G8E00_06965	COG1454	alcohol dehydrogenase
G8E00_06970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G8E00_06995	COG0069	glutamate synthase activity
G8E00_07000	COG2850	peptidyl-arginine hydroxylation
G8E00_07020	COG0126	phosphoglycerate kinase activity
G8E00_07040	COG0697	spore germination
G8E00_07065	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G8E00_07070	COG0730	response to heat
G8E00_07090	COG4773	Receptor
G8E00_07095	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G8E00_07120	COG3121	Chaperone
G8E00_07175	COG2814	Major facilitator Superfamily
G8E00_07205	COG4589	Belongs to the CDS family
G8E00_07220	COG0671	phosphoesterase, PA-phosphatase related
G8E00_07220	COG2453	phosphatase
G8E00_07225	COG2267	carboxylic ester hydrolase activity
G8E00_07230	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G8E00_07255	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G8E00_07305	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G8E00_07325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G8E00_07335	COG0133	tryptophan synthase activity
G8E00_07350	COG0517	IMP dehydrogenase activity
G8E00_07380	COG0612	Peptidase, M16
G8E00_07385	COG0552	protein localization to endoplasmic reticulum
G8E00_07420	COG4890	Cyd operon protein YbgT
G8E00_07425	COG1294	oxidase, subunit
G8E00_07440	COG1585	Membrane protein implicated in regulation of membrane protease activity
G8E00_07450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G8E00_07455	COG2153	protein acetylation
G8E00_07460	COG3539	Fimbrial protein
G8E00_07520	COG2031	fatty acid transporter
G8E00_07525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G8E00_07540	COG4770	biotin carboxylase activity
G8E00_07545	COG1024	Enoyl-CoA hydratase
G8E00_07550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G8E00_07555	COG1960	acyl-CoA dehydrogenase activity
G8E00_07560	COG1309	transcriptional regulator
G8E00_07565	COG0318	PFAM AMP-dependent synthetase and ligase
G8E00_07570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G8E00_07570	COG2226	methyltransferase
G8E00_07570	COG0596	Alpha beta hydrolase
G8E00_07575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G8E00_07600	COG0318	PFAM AMP-dependent synthetase and ligase
G8E00_07605	COG2072	flavoprotein involved in K transport
G8E00_07615	COG1073	alpha beta
G8E00_07625	COG0642	Histidine kinase
G8E00_07630	COG0745	RESPONSE REGULATOR receiver
G8E00_07635	COG2194	sulfuric ester hydrolase activity
G8E00_07660	COG0500	methyltransferase
G8E00_07670	COG2223	nitrite transmembrane transporter activity
G8E00_07675	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
G8E00_07690	COG1024	Enoyl-CoA hydratase
G8E00_07695	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8E00_07700	COG0183	Belongs to the thiolase family
G8E00_07705	COG1960	acyl-CoA dehydrogenase activity
G8E00_07710	COG1846	Transcriptional regulator
G8E00_07715	COG1028	Short-chain dehydrogenase reductase Sdr
G8E00_07720	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G8E00_07730	COG0318	PFAM AMP-dependent synthetase and ligase
G8E00_07755	COG0439	Biotin carboxylase
G8E00_07760	COG1196	nuclear chromosome segregation
G8E00_07765	COG0864	Transcriptional regulator
G8E00_07780	COG0583	DNA-binding transcription factor activity
G8E00_07795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G8E00_07800	COG1960	acyl-CoA dehydrogenase activity
G8E00_07805	COG1024	Enoyl-CoA hydratase
G8E00_07815	COG0477	Major facilitator Superfamily
G8E00_07820	COG4628	conserved protein (DUF2132)
G8E00_07865	COG0583	DNA-binding transcription factor activity
G8E00_07880	COG1741	Belongs to the pirin family
G8E00_07885	COG1335	isochorismatase
G8E00_07890	COG2259	Doxx family
G8E00_07895	COG1741	Belongs to the pirin family
G8E00_07965	COG3209	COG3209 Rhs family protein
G8E00_07975	COG2706	6-phosphogluconolactonase activity
G8E00_07980	COG1944	ATP diphosphatase activity
G8E00_07985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8E00_07990	COG1116	anion transmembrane transporter activity
G8E00_08020	COG3209	COG3209 Rhs family protein
G8E00_08030	COG3501	Rhs element vgr protein
G8E00_08050	COG3122	Protein conserved in bacteria
G8E00_08075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G8E00_08105	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G8E00_08125	COG1132	(ABC) transporter
G8E00_08150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G8E00_08155	COG5001	Diguanylate cyclase
G8E00_08155	COG3300	MHYT domain
G8E00_08160	COG0596	Alpha beta hydrolase
G8E00_08175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G8E00_08185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8E00_08190	COG0697	spore germination
G8E00_08235	COG1960	acyl-CoA dehydrogenase activity
G8E00_08240	COG0583	DNA-binding transcription factor activity
G8E00_08245	COG3152	Membrane
G8E00_08255	COG1294	oxidase, subunit
G8E00_08260	COG1271	oxidase subunit
G8E00_08275	COG2814	Major facilitator Superfamily
G8E00_08290	COG1598	PFAM Uncharacterised protein family UPF0150
G8E00_08305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G8E00_08310	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
G8E00_08345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G8E00_08355	COG0511	ligase activity, forming carbon-carbon bonds
G8E00_08360	COG0439	Biotin carboxylase
G8E00_08370	COG3706	GGDEF domain
G8E00_08375	COG2814	Major facilitator Superfamily
G8E00_08380	COG3042	response to heat
G8E00_08385	COG0589	response to stress
G8E00_08415	COG1278	Cold shock
G8E00_08435	COG1960	acyl-CoA dehydrogenase activity
G8E00_08440	COG1960	acyl-CoA dehydrogenase activity
G8E00_08470	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G8E00_08475	COG2207	Transcriptional regulator
G8E00_08480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G8E00_08510	COG0822	iron-sulfur transferase activity
G8E00_08515	COG0316	Belongs to the HesB IscA family
G8E00_08545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G8E00_08565	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G8E00_08570	COG0702	epimerase
G8E00_08590	COG1011	Hydrolase
G8E00_08595	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G8E00_08600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G8E00_08605	COG2137	regulation of response to DNA damage stimulus
G8E00_08620	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G8E00_08630	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G8E00_08640	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G8E00_08655	COG0575	Belongs to the CDS family
G8E00_08660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G8E00_08680	COG3852	Histidine kinase
G8E00_08685	COG2204	response regulator
G8E00_08700	COG0372	Belongs to the citrate synthase family
G8E00_08730	COG0542	response to heat
G8E00_08735	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G8E00_08760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G8E00_08765	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G8E00_08775	COG0569	domain protein
G8E00_08780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G8E00_08790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G8E00_08795	COG0583	DNA-binding transcription factor activity
G8E00_08820	COG0667	Aldo Keto reductase
G8E00_08825	COG0583	DNA-binding transcription factor activity
G8E00_08875	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
G8E00_08890	COG0778	Nitroreductase
G8E00_08900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8E00_08910	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G8E00_08915	COG0148	phosphopyruvate hydratase activity
G8E00_08950	COG1902	pentaerythritol trinitrate reductase activity
G8E00_08950	COG0446	pyridine nucleotide-disulphide oxidoreductase
G8E00_08960	COG2267	carboxylic ester hydrolase activity
G8E00_08975	COG2814	Major facilitator Superfamily
G8E00_08980	COG1960	acyl-CoA dehydrogenase activity
G8E00_08985	COG0583	DNA-binding transcription factor activity
G8E00_08990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G8E00_09000	COG1027	Aspartate ammonia-lyase
G8E00_09005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G8E00_09015	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G8E00_09015	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G8E00_09015	COG0506	proline dehydrogenase activity
G8E00_09025	COG0308	aminopeptidase N
G8E00_09060	COG4115	mRNA cleavage
G8E00_09070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G8E00_09100	COG0531	amino acid
G8E00_09105	COG4303	Ethanolamine ammonia lyase large subunit
G8E00_09110	COG4302	ethanolamine ammonia-lyase activity
G8E00_09130	COG1064	alcohol dehydrogenase
G8E00_09145	COG0405	Gamma-glutamyltransferase
G8E00_09150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G8E00_09150	COG0519	Catalyzes the synthesis of GMP from XMP
G8E00_09175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G8E00_09185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G8E00_09225	COG1254	Belongs to the acylphosphatase family
G8E00_09230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G8E00_09230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G8E00_09265	COG3433	isochorismatase activity
G8E00_09265	COG1535	isochorismatase
G8E00_09270	COG1021	2,3-dihydroxybenzoate-AMP ligase
G8E00_09275	COG1169	isochorismate synthase
G8E00_09280	COG1028	Short-chain dehydrogenase reductase Sdr
G8E00_09300	COG0477	Major facilitator Superfamily
G8E00_09325	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
G8E00_09330	COG4771	TonB-dependent receptor
G8E00_09345	COG0204	Acyl-transferase
G8E00_09390	COG1464	Belongs to the NlpA lipoprotein family
G8E00_09400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G8E00_09405	COG2011	ABC-type metal ion transport system permease component
G8E00_09410	COG0012	GTP binding
G8E00_09420	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G8E00_09430	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
G8E00_09440	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
G8E00_09450	COG0436	Aminotransferase
G8E00_09495	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G8E00_09520	COG2165	general secretion pathway protein
G8E00_09530	COG0084	hydrolase, TatD family'
G8E00_09550	COG1663	tetraacyldisaccharide 4'-kinase activity
G8E00_09555	COG1132	(ABC) transporter
G8E00_09565	COG0811	peptide transport
G8E00_09570	COG1475	DNA binding
G8E00_09575	COG1192	Involved in chromosome partitioning
G8E00_09585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G8E00_09590	COG3178	'Phosphotransferase
G8E00_09600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G8E00_09605	COG1923	regulation of RNA biosynthetic process
G8E00_09615	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G8E00_09620	COG0802	atpase or kinase
G8E00_09640	COG1187	pseudouridine synthase activity
G8E00_09655	COG2707	UPF0756 membrane protein
G8E00_09660	COG0668	transmembrane transport
G8E00_09665	COG0583	DNA-binding transcription factor activity
G8E00_09680	COG0786	glutamate:sodium symporter activity
G8E00_09695	COG2132	Multicopper oxidase
G8E00_09730	COG2911	Protein conserved in bacteria
G8E00_09735	COG0729	surface antigen
G8E00_09775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G8E00_09785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8E00_09790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8E00_09795	COG2890	protein-(glutamine-N5) methyltransferase activity
G8E00_09815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8E00_09820	COG4682	membrane
G8E00_09840	COG1215	transferase activity, transferring glycosyl groups
G8E00_09845	COG0726	polysaccharide deacetylase
G8E00_09845	COG1649	PFAM Uncharacterised BCR, COG1649
G8E00_09875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G8E00_09880	COG1845	cytochrome c oxidase, subunit III
G8E00_09885	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G8E00_09905	COG1505	serine-type exopeptidase activity
G8E00_09910	COG0360	Binds together with S18 to 16S ribosomal RNA
G8E00_09915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G8E00_09925	COG0305	Participates in initiation and elongation during chromosome replication
G8E00_09935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G8E00_09950	COG1305	Transglutaminase-like
G8E00_09960	COG2308	Evidence 4 Homologs of previously reported genes of
G8E00_09970	COG2814	Major facilitator Superfamily
G8E00_10000	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
G8E00_10005	COG0138	bifunctional purine biosynthesis protein purh
G8E00_10020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G8E00_10035	COG1464	Belongs to the NlpA lipoprotein family
G8E00_10040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G8E00_10045	COG2011	ABC-type metal ion transport system permease component
G8E00_10125	COG1610	YqeY-like protein
G8E00_10135	COG4783	chaperone-mediated protein folding
G8E00_10190	COG0778	Nitroreductase
G8E00_10200	COG0513	Belongs to the DEAD box helicase family
G8E00_10205	COG1278	Cold shock
G8E00_10220	COG2363	Small membrane protein
G8E00_10225	COG0625	glutathione transferase activity
G8E00_10230	COG0659	secondary active sulfate transmembrane transporter activity
G8E00_10235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G8E00_10255	COG3047	cAMP biosynthetic process
G8E00_10255	COG2885	chlorophyll binding
G8E00_10275	COG0540	Belongs to the ATCase OTCase family
G8E00_10315	COG0542	response to heat
G8E00_10325	COG1765	OsmC-like protein
G8E00_10335	COG0667	Aldo Keto reductase
G8E00_10355	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G8E00_10365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G8E00_10375	COG0527	aspartate kinase activity
G8E00_10385	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G8E00_10395	COG3038	cytochrome b561
G8E00_10405	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G8E00_10410	COG2252	PERMEase
G8E00_10470	COG0714	Associated with various cellular activities
G8E00_10480	COG1966	Carbon starvation protein
G8E00_10485	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G8E00_10490	COG1509	lysine 2,3-aminomutase activity
G8E00_10520	COG2211	Major facilitator Superfamily
G8E00_10525	COG1067	ATP-dependent peptidase activity
G8E00_10535	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G8E00_10540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G8E00_10545	COG0583	DNA-binding transcription factor activity
G8E00_10570	COG1686	Belongs to the peptidase S11 family
G8E00_10575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G8E00_10595	COG0482	sulfurtransferase activity
G8E00_10620	COG0616	signal peptide processing
G8E00_10640	COG2255	four-way junction helicase activity
G8E00_10650	COG0824	Thioesterase
G8E00_10670	COG0823	Involved in the tonB-independent uptake of proteins
G8E00_10675	COG2885	chlorophyll binding
G8E00_10690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8E00_10720	COG3040	lipid binding
G8E00_10755	COG1113	amino acid transport
G8E00_10765	COG1131	(ABC) transporter
G8E00_10770	COG0842	Transport permease protein
G8E00_10785	COG0772	Belongs to the SEDS family
G8E00_10790	COG2951	lytic endotransglycosylase activity
G8E00_10810	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G8E00_10815	COG0052	Belongs to the universal ribosomal protein uS2 family
G8E00_10820	COG0024	Methionine aminopeptidase
G8E00_10835	COG2175	clavaminate synthase activity
G8E00_10840	COG0583	DNA-binding transcription factor activity
G8E00_10855	COG1289	transmembrane transporter activity
G8E00_10860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G8E00_10865	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G8E00_10870	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
G8E00_10885	COG4172	Belongs to the ABC transporter superfamily
G8E00_10890	COG4239	(ABC) transporter, permease
G8E00_10895	COG4174	ABC transporter (Permease)
G8E00_10905	COG0741	lytic transglycosylase activity
G8E00_10905	COG1388	LysM domain
G8E00_10910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G8E00_10920	COG2816	NAD+ diphosphatase activity
G8E00_10940	COG3107	peptidoglycan biosynthetic process
G8E00_10955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G8E00_10960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G8E00_10975	COG0006	proline dipeptidase activity
G8E00_11000	COG0730	response to heat
G8E00_11005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G8E00_11060	COG4774	siderophore transport
G8E00_11080	COG4580	involved in the transport of maltose and maltodextrins
G8E00_11095	COG0183	Belongs to the thiolase family
G8E00_11100	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G8E00_11105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G8E00_11110	COG3485	protocatechuate 3,4-dioxygenase
G8E00_11125	COG0673	inositol 2-dehydrogenase activity
G8E00_11130	COG4213	ABC transporter substrate-binding protein
G8E00_11140	COG4214	carbohydrate transport
G8E00_11145	COG0673	inositol 2-dehydrogenase activity
G8E00_11165	COG0446	pyridine nucleotide-disulphide oxidoreductase
G8E00_11165	COG1902	pentaerythritol trinitrate reductase activity
G8E00_11170	COG0277	FAD linked oxidase domain protein
G8E00_11180	COG2186	Transcriptional regulator
G8E00_11185	COG1620	l-lactate permease
G8E00_11190	COG0737	Belongs to the 5'-nucleotidase family
G8E00_11200	COG4251	negative regulation of phosphorylation
G8E00_11200	COG5001	Diguanylate cyclase
G8E00_11200	COG2203	Gaf domain
G8E00_11200	COG3706	GGDEF domain
G8E00_11205	COG4251	negative regulation of phosphorylation
G8E00_11205	COG3706	GGDEF domain
G8E00_11205	COG2203	Gaf domain
G8E00_11205	COG5001	Diguanylate cyclase
G8E00_11210	COG2203	Gaf domain
G8E00_11210	COG5001	Diguanylate cyclase
G8E00_11210	COG3706	GGDEF domain
G8E00_11210	COG4251	negative regulation of phosphorylation
G8E00_11220	COG0418	dihydroorotase activity
G8E00_11225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G8E00_11250	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G8E00_11260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8E00_11275	COG1301	dicarboxylic acid transport
G8E00_11305	COG1280	lysine exporter protein (LysE YggA)
G8E00_11310	COG1522	sequence-specific DNA binding
G8E00_11345	COG0019	diaminopimelate decarboxylase activity
G8E00_11355	COG1113	amino acid transport
G8E00_11360	COG1115	amino acid carrier protein
G8E00_11380	COG1794	racemase activity, acting on amino acids and derivatives
G8E00_11385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G8E00_11395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G8E00_11430	COG0772	Belongs to the SEDS family
G8E00_11435	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G8E00_11460	COG0174	glutamine synthetase
G8E00_11475	COG0512	Glutamine amidotransferase of anthranilate synthase
G8E00_11480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G8E00_11485	COG0134	indole-3-glycerol-phosphate synthase activity
G8E00_11505	COG0302	gtp cyclohydrolase
G8E00_11515	COG3706	GGDEF domain
G8E00_11530	COG3739	integral membrane protein
G8E00_11535	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G8E00_11545	COG1741	Belongs to the pirin family
G8E00_11555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G8E00_11590	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G8E00_11600	COG0583	DNA-binding transcription factor activity
G8E00_11605	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
G8E00_11615	COG0037	tRNA processing
G8E00_11620	COG0741	lytic transglycosylase activity
G8E00_11620	COG0739	heme binding
G8E00_11620	COG1196	nuclear chromosome segregation
G8E00_11625	COG0501	Belongs to the peptidase M48B family
G8E00_11640	COG2239	Acts as a magnesium transporter
G8E00_11645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G8E00_11650	COG0584	glycerophosphoryl diester phosphodiesterase
G8E00_11670	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G8E00_11675	COG1597	lipid kinase activity
G8E00_11680	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
G8E00_11685	COG0477	Major facilitator Superfamily
G8E00_11700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G8E00_11735	COG2304	oxidoreductase activity
G8E00_11740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G8E00_11745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G8E00_11770	COG0505	Belongs to the CarA family
G8E00_11775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G8E00_11785	COG0110	maltose O-acetyltransferase activity
G8E00_11830	COG2321	neutral zinc metallopeptidase
G8E00_11835	COG2354	Protein conserved in bacteria
G8E00_11845	COG1585	Membrane protein implicated in regulation of membrane protease activity
G8E00_11850	COG2268	Band 7 protein
G8E00_11865	COG3023	N-Acetylmuramoyl-L-alanine amidase
G8E00_11890	COG1253	flavin adenine dinucleotide binding
G8E00_11905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8E00_11920	COG0805	protein transport
G8E00_11955	COG0004	ammonium transporteR
G8E00_11975	COG1752	Esterase of the alpha-beta hydrolase superfamily
G8E00_11990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G8E00_11995	COG0142	geranyltranstransferase activity
G8E00_12005	COG2828	Protein conserved in bacteria
G8E00_12010	COG1113	amino acid transport
G8E00_12040	COG0560	Phosphoserine phosphatase
G8E00_12050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G8E00_12060	COG1530	ribonuclease E activity
G8E00_12065	COG0424	maF-like protein
G8E00_12070	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
G8E00_12075	COG1792	Involved in formation and maintenance of cell shape
G8E00_12080	COG1077	Cell shape determining protein MreB Mrl
G8E00_12085	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G8E00_12095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G8E00_12150	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
G8E00_12165	COG1215	transferase activity, transferring glycosyl groups
G8E00_12170	COG1649	PFAM Uncharacterised BCR, COG1649
G8E00_12170	COG0726	polysaccharide deacetylase
G8E00_12185	COG4681	YaeQ
G8E00_12195	COG0523	cobalamin synthesis protein
G8E00_12210	COG1607	acyl-coa hydrolase
G8E00_12220	COG1752	Esterase of the alpha-beta hydrolase superfamily
G8E00_12225	COG0786	glutamate:sodium symporter activity
G8E00_12240	COG2814	Major facilitator Superfamily
G8E00_12245	COG1289	transmembrane transporter activity
G8E00_12255	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G8E00_12315	COG2832	Protein of unknown function (DUF454)
G8E00_12340	COG0643	Histidine kinase
G8E00_12340	COG0784	Response regulator, receiver
G8E00_12340	COG2198	Histidine kinase
G8E00_12345	COG0840	transmembrane signaling receptor activity
G8E00_12370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8E00_12380	COG0442	prolyl-tRNA aminoacylation
G8E00_12410	COG1045	serine acetyltransferase
G8E00_12425	COG0489	protein tyrosine kinase activity
G8E00_12450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8E00_12450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8E00_12460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G8E00_12510	COG2081	HI0933 family
G8E00_12525	COG0668	transmembrane transport
G8E00_12545	COG0583	DNA-binding transcription factor activity
G8E00_12555	COG1278	Cold shock
G8E00_12565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G8E00_12575	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G8E00_12580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G8E00_12585	COG0713	ATP synthesis coupled electron transport
G8E00_12595	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G8E00_12610	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G8E00_12645	COG0745	RESPONSE REGULATOR receiver
G8E00_12655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G8E00_12705	COG3152	Membrane
G8E00_12710	COG2314	TM2 domain
G8E00_12715	COG1652	LysM domain
G8E00_12725	COG1028	Short-chain dehydrogenase reductase Sdr
G8E00_12735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G8E00_12740	COG1399	metal-binding, possibly nucleic acid-binding protein
G8E00_12745	COG3101	peptidyl-lysine hydroxylation
G8E00_12750	COG0009	L-threonylcarbamoyladenylate synthase
G8E00_12760	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G8E00_12765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G8E00_12785	COG4106	trans-aconitate 2-methyltransferase activity
G8E00_12810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G8E00_12820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G8E00_12830	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G8E00_12840	COG1196	nuclear chromosome segregation
G8E00_12850	COG0730	response to heat
G8E00_12855	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
G8E00_12855	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
G8E00_12860	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G8E00_12870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G8E00_12875	COG4137	Cytochrome C assembly protein
G8E00_12880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G8E00_12895	COG0494	nUDIX hydrolase
G8E00_12910	COG3422	double-strand break repair
G8E00_12915	COG2824	Alkylphosphonate utilization operon protein PhnA
G8E00_12925	COG0628	permease
G8E00_12940	COG0564	pseudouridine synthase activity
G8E00_12970	COG3293	Transposase
G8E00_13000	COG0354	folic acid binding
G8E00_13040	COG4772	TonB-dependent receptor
G8E00_13045	COG3659	wide pore channel activity
G8E00_13055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G8E00_13060	COG1011	Hydrolase
G8E00_13065	COG1970	mechanosensitive ion channel activity
G8E00_13075	COG2233	PERMEase
G8E00_13085	COG0833	amino acid
G8E00_13105	COG0183	Belongs to the thiolase family
G8E00_13125	COG0484	heat shock protein binding
G8E00_13135	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G8E00_13180	COG4206	TonB-dependent receptor
G8E00_13185	COG2096	Adenosyltransferase
G8E00_13215	COG2315	Protein conserved in bacteria
G8E00_13220	COG0745	RESPONSE REGULATOR receiver
G8E00_13225	COG2205	protein histidine kinase activity
G8E00_13235	COG1960	acyl-CoA dehydrogenase activity
G8E00_13240	COG1960	acyl-CoA dehydrogenase activity
G8E00_13275	COG3307	-O-antigen
G8E00_13285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G8E00_13310	COG1215	transferase activity, transferring glycosyl groups
G8E00_13335	COG1091	dTDP-4-dehydrorhamnose reductase activity
G8E00_13370	COG0438	transferase activity, transferring glycosyl groups
G8E00_13380	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G8E00_13395	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G8E00_13400	COG5002	protein histidine kinase activity
G8E00_13400	COG2205	protein histidine kinase activity
G8E00_13400	COG0784	Response regulator, receiver
G8E00_13410	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G8E00_13440	COG1862	Preprotein translocase
G8E00_13465	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G8E00_13485	COG1426	Protein conserved in bacteria
G8E00_13535	COG0440	acetolactate synthase activity
G8E00_13540	COG0028	Belongs to the TPP enzyme family
G8E00_13565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8E00_13570	COG1136	(ABC) transporter
G8E00_13570	COG0577	efflux transmembrane transporter activity
G8E00_13585	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G8E00_13590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G8E00_13600	COG3501	Rhs element vgr protein
G8E00_13615	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G8E00_13620	COG1162	GTPase activity
G8E00_13630	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G8E00_13645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G8E00_13650	COG2003	Belongs to the UPF0758 family
G8E00_13655	COG3781	membrane
G8E00_13670	COG2350	Protein conserved in bacteria
G8E00_13685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G8E00_13705	COG1607	acyl-coa hydrolase
G8E00_13770	COG1183	phosphatidylcholine synthase activity
G8E00_13775	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G8E00_13810	COG0741	lytic transglycosylase activity
G8E00_13810	COG1196	nuclear chromosome segregation
G8E00_13810	COG0739	heme binding
G8E00_13815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G8E00_13820	COG1702	phosphate starvation-inducible protein PhoH
G8E00_13830	COG0668	transmembrane transport
G8E00_13860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8E00_13875	COG1295	ribonuclease BN
G8E00_13880	COG0179	Fumarylacetoacetate (FAA) hydrolase
G8E00_13925	COG0557	exoribonuclease II activity
G8E00_13935	COG0339	signal peptide processing
G8E00_13940	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
G8E00_13970	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G8E00_13975	COG1960	acyl-CoA dehydrogenase activity
G8E00_13980	COG0546	phosphoglycolate phosphatase activity
G8E00_13990	COG1530	ribonuclease E activity
G8E00_13995	COG0318	PFAM AMP-dependent synthetase and ligase
G8E00_14020	COG1983	PspC domain protein
G8E00_14040	COG0471	metal ion transport
G8E00_14065	COG0751	glycine-tRNA ligase activity
G8E00_14075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G8E00_14105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8E00_14155	COG0628	permease
G8E00_14160	COG2032	superoxide dismutase activity
G8E00_14165	COG2814	Major facilitator Superfamily
G8E00_14210	COG0277	FAD linked oxidase domain protein
G8E00_14215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G8E00_14220	COG5006	permease, DMT superfamily
G8E00_14240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G8E00_14245	COG5380	lipid catabolic process
G8E00_14250	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
G8E00_14255	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
G8E00_14260	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
G8E00_14265	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
G8E00_14270	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
G8E00_14275	COG0335	large ribosomal subunit rRNA binding
G8E00_14285	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G8E00_14290	COG0228	four-way junction DNA binding
G8E00_14300	COG4969	Belongs to the N-Me-Phe pilin family
G8E00_14325	COG4969	Belongs to the N-Me-Phe pilin family
G8E00_14330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G8E00_14335	COG0194	GDP metabolic process
G8E00_14340	COG1758	RNA polymerase activity
G8E00_14345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G8E00_14365	COG3307	-O-antigen
G8E00_14370	COG3307	-O-antigen
G8E00_14385	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G8E00_14390	COG1704	LemA family
G8E00_14400	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G8E00_14405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G8E00_14410	COG0195	Participates in both transcription termination and antitermination
G8E00_14415	COG0779	Required for maturation of 30S ribosomal subunits
G8E00_14465	COG0237	dephospho-CoA kinase activity
G8E00_14475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8E00_14485	COG0497	DNA recombination
G8E00_14500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G8E00_14530	COG1132	(ABC) transporter
G8E00_14545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G8E00_14580	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8E00_14580	COG1024	Enoyl-CoA hydratase
G8E00_14585	COG0183	Belongs to the thiolase family
G8E00_14590	COG3706	GGDEF domain
G8E00_14610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G8E00_14630	COG0326	Molecular chaperone. Has ATPase activity
G8E00_14645	COG2056	Na+-H+ antiporter family
G8E00_14675	COG0085	RNA polymerase activity
G8E00_14690	COG0081	regulation of translation
G8E00_14705	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G8E00_14745	COG0546	phosphoglycolate phosphatase activity
G8E00_14795	COG0181	hydroxymethylbilane synthase activity
G8E00_14805	COG3275	phosphorelay sensor kinase activity
G8E00_14825	COG1538	Outer membrane efflux protein
G8E00_14845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G8E00_14850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G8E00_14860	COG0772	Belongs to the SEDS family
G8E00_14890	COG4974	Belongs to the 'phage' integrase family
G8E00_14895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G8E00_14905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G8E00_14915	COG1686	Belongs to the peptidase S11 family
G8E00_14920	COG2197	response regulator
G8E00_14935	COG0793	Belongs to the peptidase S41A family
G8E00_14940	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
G8E00_14945	COG0795	lipopolysaccharide-transporting ATPase activity
G8E00_14950	COG0795	lipopolysaccharide-transporting ATPase activity
G8E00_14970	COG0586	Pfam SNARE associated Golgi protein
G8E00_14985	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G8E00_14985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G8E00_14990	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G8E00_14995	COG0004	ammonium transporteR
G8E00_15000	COG0347	Belongs to the P(II) protein family
G8E00_15020	COG0659	secondary active sulfate transmembrane transporter activity
G8E00_15025	COG0589	response to stress
G8E00_15035	COG0640	Transcriptional regulator
G8E00_15045	COG0798	PFAM Bile acid sodium symporter
G8E00_15050	COG0431	NADPH-dependent FMN reductase
G8E00_15055	COG0492	ferredoxin-NADP+ reductase activity
G8E00_15090	COG0606	chelatase, subunit chli
G8E00_15110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G8E00_15125	COG0318	PFAM AMP-dependent synthetase and ligase
G8E00_15135	COG0477	Major facilitator Superfamily
G8E00_15140	COG2860	membrane
G8E00_15150	COG1253	flavin adenine dinucleotide binding
G8E00_15160	COG2814	Major facilitator Superfamily
G8E00_15170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G8E00_15175	COG0477	Major facilitator Superfamily
G8E00_15205	COG2814	Major facilitator Superfamily
G8E00_15270	COG0758	DNA mediated transformation
G8E00_15280	COG0697	spore germination
G8E00_15290	COG0386	Belongs to the glutathione peroxidase family
G8E00_15320	COG1028	Short-chain dehydrogenase reductase Sdr
G8E00_15350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G8E00_15400	COG1121	(ABC) transporter
G8E00_15405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G8E00_15410	COG0668	transmembrane transport
G8E00_15415	COG1280	lysine exporter protein (LysE YggA)
G8E00_15425	COG2837	iron assimilation
G8E00_15450	COG3501	Rhs element vgr protein
G8E00_15455	COG0281	malic enzyme
G8E00_15485	COG3150	esterase
G8E00_15510	COG2918	glutathione biosynthetic process
G8E00_15525	COG2733	membrane
G8E00_15535	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G8E00_15535	COG2755	lipolytic protein G-D-S-L family
G8E00_15540	COG0436	Aminotransferase
G8E00_15545	COG0534	Mate efflux family protein
G8E00_15550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8E00_15565	COG3829	transcription factor binding
G8E00_15570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8E00_15580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8E00_15585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8E00_15665	COG0753	catalase activity
G8E00_15685	COG0560	Phosphoserine phosphatase
G8E00_15685	COG3830	Belongs to the UPF0237 family
G8E00_15710	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G8E00_15715	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G8E00_15725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G8E00_15760	COG1002	Type II restriction enzyme, methylase subunits
G8E00_15765	COG1061	Type III restriction enzyme res subunit
G8E00_15775	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G8E00_15790	COG0730	response to heat
G8E00_15810	COG1683	Conserved Protein
G8E00_15820	COG0385	Bile acid
G8E00_15825	COG1335	isochorismatase
G8E00_15830	COG2814	Major facilitator Superfamily
G8E00_15835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G8E00_15855	COG0584	glycerophosphoryl diester phosphodiesterase
G8E00_15865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G8E00_15870	COG2133	pyrroloquinoline quinone binding
G8E00_15875	COG2983	Belongs to the UPF0260 family
G8E00_15880	COG5487	UPF0391 membrane protein
G8E00_15895	COG1194	a g-specific adenine glycosylase
G8E00_15910	COG2818	Glycosylase
G8E00_15925	COG2814	Major facilitator Superfamily
G8E00_15950	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G8E00_15950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G8E00_15955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8E00_15960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8E00_15965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8E00_15970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8E00_15975	COG1116	anion transmembrane transporter activity
G8E00_15980	COG1309	transcriptional regulator
G8E00_15990	COG0196	riboflavin kinase activity
G8E00_15995	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G8E00_16005	COG1047	Peptidyl-prolyl cis-trans
G8E00_16165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G8E00_16185	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G8E00_16195	COG0789	Transcriptional regulator
G8E00_16210	COG0488	(ABC) transporter
G8E00_16215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G8E00_16220	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G8E00_16240	COG0596	Alpha beta hydrolase
G8E00_16270	COG0187	DNA topoisomerase II activity
G8E00_16280	COG0592	DNA-directed DNA polymerase activity