locus-tag	class	description
MKL45_00010	COG0592	DNA-directed DNA polymerase activity
MKL45_00020	COG0187	DNA topoisomerase II activity
MKL45_00030	COG0586	Pfam SNARE associated Golgi protein
MKL45_00035	COG0488	(ABC) transporter
MKL45_00060	COG0596	Alpha beta hydrolase
MKL45_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MKL45_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MKL45_00110	COG1047	Peptidyl-prolyl cis-trans
MKL45_00120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MKL45_00125	COG0196	riboflavin kinase activity
MKL45_00135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MKL45_00140	COG1309	transcriptional regulator
MKL45_00145	COG1116	anion transmembrane transporter activity
MKL45_00150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MKL45_00155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKL45_00160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MKL45_00165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MKL45_00185	COG1028	Short-chain dehydrogenase reductase Sdr
MKL45_00190	COG0546	phosphoglycolate phosphatase activity
MKL45_00250	COG3023	N-Acetylmuramoyl-L-alanine amidase
MKL45_00255	COG0728	peptidoglycan biosynthetic process
MKL45_00280	COG1596	polysaccharide export
MKL45_00285	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MKL45_00295	COG1091	dTDP-4-dehydrorhamnose reductase activity
MKL45_00300	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MKL45_00325	COG0463	Glycosyl transferase, family 2
MKL45_00325	COG1216	Glycosyl transferase, family 2
MKL45_00330	COG0110	maltose O-acetyltransferase activity
MKL45_00345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MKL45_00350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MKL45_00370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MKL45_00380	COG2186	Transcriptional regulator
MKL45_00390	COG0277	FAD linked oxidase domain protein
MKL45_00395	COG1448	Aminotransferase
MKL45_00400	COG1802	Transcriptional regulator
MKL45_00415	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MKL45_00445	COG0564	pseudouridine synthase activity
MKL45_00485	COG0251	oxidation-reduction process
MKL45_00490	COG1113	amino acid transport
MKL45_00495	COG1113	amino acid transport
MKL45_00515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MKL45_00520	COG1960	acyl-CoA dehydrogenase activity
MKL45_00525	COG1024	Enoyl-CoA hydratase
MKL45_00530	COG1024	Enoyl-CoA hydratase
MKL45_00535	COG0477	Major facilitator Superfamily
MKL45_00540	COG3916	Acyl-homoserine-lactone synthase
MKL45_00550	COG2197	response regulator
MKL45_00560	COG1960	acyl-CoA dehydrogenase activity
MKL45_00565	COG3321	synthase
MKL45_00565	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
MKL45_00565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MKL45_00565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MKL45_00585	COG2267	carboxylic ester hydrolase activity
MKL45_00605	COG0271	Belongs to the BolA IbaG family
MKL45_00615	COG1192	Involved in chromosome partitioning
MKL45_00630	COG0586	Pfam SNARE associated Golgi protein
MKL45_00635	COG2259	Doxx family
MKL45_00640	COG4399	Belongs to the UPF0754 family
MKL45_00645	COG0519	Catalyzes the synthesis of GMP from XMP
MKL45_00645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MKL45_00690	COG0281	malic enzyme
MKL45_00695	COG2837	iron assimilation
MKL45_00700	COG1280	lysine exporter protein (LysE YggA)
MKL45_00705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MKL45_00710	COG1121	(ABC) transporter
MKL45_00775	COG0386	Belongs to the glutathione peroxidase family
MKL45_00790	COG1309	transcriptional regulator
MKL45_00795	COG0697	spore germination
MKL45_00805	COG0758	DNA mediated transformation
MKL45_00875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MKL45_00885	COG0655	NAD(P)H dehydrogenase (quinone) activity
MKL45_00925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MKL45_00935	COG0477	Major facilitator Superfamily
MKL45_00945	COG1253	flavin adenine dinucleotide binding
MKL45_00950	COG3012	SEC-C Motif Domain Protein
MKL45_00955	COG2860	membrane
MKL45_00960	COG0477	Major facilitator Superfamily
MKL45_00970	COG0318	PFAM AMP-dependent synthetase and ligase
MKL45_00985	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MKL45_01005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MKL45_01060	COG0589	response to stress
MKL45_01065	COG0659	secondary active sulfate transmembrane transporter activity
MKL45_01085	COG0347	Belongs to the P(II) protein family
MKL45_01090	COG0004	ammonium transporteR
MKL45_01100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MKL45_01100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MKL45_01140	COG0795	lipopolysaccharide-transporting ATPase activity
MKL45_01145	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MKL45_01150	COG0793	Belongs to the peptidase S41A family
MKL45_01165	COG2197	response regulator
MKL45_01175	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MKL45_01185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MKL45_01190	COG4974	Belongs to the 'phage' integrase family
MKL45_01215	COG0772	Belongs to the SEDS family
MKL45_01220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MKL45_01225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MKL45_01230	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MKL45_01255	COG0697	spore germination
MKL45_01260	COG1538	Outer membrane efflux protein
MKL45_01280	COG3275	phosphorelay sensor kinase activity
MKL45_01290	COG0181	hydroxymethylbilane synthase activity
MKL45_01335	COG1716	ATPase activity
MKL45_01340	COG0546	phosphoglycolate phosphatase activity
MKL45_01435	COG0596	Alpha beta hydrolase
MKL45_01440	COG2056	Na+-H+ antiporter family
MKL45_01455	COG0326	Molecular chaperone. Has ATPase activity
MKL45_01470	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MKL45_01540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MKL45_01575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MKL45_01585	COG0497	DNA recombination
MKL45_01600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MKL45_01610	COG0237	dephospho-CoA kinase activity
MKL45_01660	COG0195	Participates in both transcription termination and antitermination
MKL45_01675	COG1320	monovalent cation:proton antiporter activity
MKL45_01680	COG2212	antiporter activity
MKL45_01685	COG1863	multisubunit Na H antiporter MnhE subunit
MKL45_01690	COG0651	ATP synthesis coupled electron transport
MKL45_01695	COG1006	Multisubunit Na H antiporter MnhC subunit
MKL45_01700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MKL45_01700	COG2111	Na H antiporter
MKL45_01715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MKL45_01745	COG2226	methyltransferase
MKL45_01765	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MKL45_01770	COG1074	ATP-dependent DNA helicase activity
MKL45_01775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MKL45_01780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MKL45_01795	COG0598	Magnesium transport protein CorA
MKL45_01800	COG0789	Transcriptional regulator
MKL45_01805	COG0484	heat shock protein binding
MKL45_01820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MKL45_01820	COG0475	glutathione-regulated potassium exporter activity
MKL45_01825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MKL45_01845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKL45_01855	COG4535	Mg2 and Co2 transporter CorC
MKL45_01860	COG0425	Belongs to the sulfur carrier protein TusA family
MKL45_01870	COG0644	oxidoreductase
MKL45_01870	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
MKL45_01880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MKL45_01895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MKL45_01900	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MKL45_01910	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MKL45_01910	COG0493	'glutamate synthase
MKL45_01935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MKL45_01950	COG0534	Mate efflux family protein
MKL45_01960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MKL45_01965	COG1028	Short-chain dehydrogenase reductase Sdr
MKL45_01970	COG0583	DNA-binding transcription factor activity
MKL45_01985	COG0318	PFAM AMP-dependent synthetase and ligase
MKL45_01990	COG1530	ribonuclease E activity
MKL45_02000	COG0546	phosphoglycolate phosphatase activity
MKL45_02005	COG2378	regulation of single-species biofilm formation
MKL45_02010	COG0625	glutathione transferase activity
MKL45_02020	COG0583	DNA-binding transcription factor activity
MKL45_02085	COG0473	3-isopropylmalate dehydrogenase activity
MKL45_02140	COG1301	dicarboxylic acid transport
MKL45_02150	COG1560	Kdo2-lipid A biosynthetic process
MKL45_02155	COG1280	lysine exporter protein (LysE YggA)
MKL45_02165	COG0488	(ABC) transporter
MKL45_02170	COG2900	Belongs to the SlyX family
MKL45_02180	COG1733	regulation of RNA biosynthetic process
MKL45_02205	COG0210	DNA helicase
MKL45_02210	COG0724	RNA recognition motif
MKL45_02230	COG4651	solute:proton antiporter activity
MKL45_02230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MKL45_02255	COG0788	formyltetrahydrofolate deformylase activity
MKL45_02355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MKL45_02355	COG2813	Specifically methylates the guanine in position
MKL45_02365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MKL45_02375	COG4774	siderophore transport
MKL45_02385	COG0740	serine-type endopeptidase activity
MKL45_02405	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MKL45_02405	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
MKL45_02410	COG0280	phosphate acetyltransferase
MKL45_02410	COG0857	belongs to the CobB CobQ family
MKL45_02415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MKL45_02425	COG0800	Aldolase
MKL45_02435	COG3265	gluconokinase activity
MKL45_02440	COG1012	belongs to the aldehyde dehydrogenase family
MKL45_02450	COG2267	carboxylic ester hydrolase activity
MKL45_02465	COG0793	Belongs to the peptidase S41A family
MKL45_02500	COG1426	Protein conserved in bacteria
MKL45_02520	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MKL45_02540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MKL45_02550	COG1162	GTPase activity
MKL45_02555	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MKL45_02570	COG1538	Outer membrane efflux protein
MKL45_02575	COG1136	(ABC) transporter
MKL45_02575	COG0577	efflux transmembrane transporter activity
MKL45_02580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKL45_02605	COG0028	Belongs to the TPP enzyme family
MKL45_02610	COG0440	acetolactate synthase activity
MKL45_02640	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MKL45_02655	COG0084	hydrolase, TatD family'
MKL45_02670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MKL45_02680	COG0583	DNA-binding transcription factor activity
MKL45_02690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MKL45_02730	COG2205	protein histidine kinase activity
MKL45_02745	COG2132	Multicopper oxidase
MKL45_02755	COG3328	transposase activity
MKL45_02775	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKL45_02810	COG0640	Transcriptional regulator
MKL45_02820	COG0798	PFAM Bile acid sodium symporter
MKL45_02825	COG0431	NADPH-dependent FMN reductase
MKL45_02830	COG0492	ferredoxin-NADP+ reductase activity
MKL45_02835	COG2072	flavoprotein involved in K transport
MKL45_02870	COG1358	cellular component organization or biogenesis
MKL45_02915	COG2814	Major facilitator Superfamily
MKL45_02925	COG0697	spore germination
MKL45_02955	COG3622	Belongs to the hyi family
MKL45_02960	COG2084	Dehydrogenase
MKL45_02965	COG1024	Enoyl-CoA hydratase
MKL45_02970	COG5002	protein histidine kinase activity
MKL45_02970	COG2205	protein histidine kinase activity
MKL45_02970	COG0784	Response regulator, receiver
MKL45_02990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MKL45_03000	COG3956	TIGRFAM MazG family protein
MKL45_03005	COG1555	photosystem II stabilization
MKL45_03010	COG0617	tRNA 3'-terminal CCA addition
MKL45_03015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MKL45_03035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKL45_03040	COG3028	Belongs to the UPF0307 family
MKL45_03045	COG0318	PFAM AMP-dependent synthetase and ligase
MKL45_03060	COG0625	glutathione transferase activity
MKL45_03065	COG1238	metal cluster binding
MKL45_03110	COG0072	phenylalanine-tRNA ligase activity
MKL45_03140	COG0248	Ppx GppA phosphatase
MKL45_03150	COG0037	tRNA processing
MKL45_03190	COG1764	response to oxidative stress
MKL45_03195	COG1846	Transcriptional regulator
MKL45_03205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MKL45_03265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MKL45_03270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MKL45_03275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MKL45_03335	COG1214	PFAM Peptidase M22, glycoprotease
MKL45_03350	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MKL45_03360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MKL45_03365	COG0561	phosphatase activity
MKL45_03375	COG2132	Multicopper oxidase
MKL45_03380	COG3667	copper resistance
MKL45_03395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MKL45_03400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MKL45_03405	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MKL45_03435	COG1063	alcohol dehydrogenase
MKL45_03440	COG0583	DNA-binding transcription factor activity
MKL45_03445	COG1960	acyl-CoA dehydrogenase activity
MKL45_03450	COG2814	Major facilitator Superfamily
MKL45_03455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MKL45_03460	COG1309	transcriptional regulator
MKL45_03475	COG1053	succinate dehydrogenase
MKL45_03480	COG0583	DNA-binding transcription factor activity
MKL45_03495	COG0583	DNA-binding transcription factor activity
MKL45_03525	COG0583	DNA-binding transcription factor activity
MKL45_03540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MKL45_03600	COG0384	phenazine biosynthesis protein PhzF
MKL45_03615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MKL45_03635	COG0745	RESPONSE REGULATOR receiver
MKL45_03675	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MKL45_03705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MKL45_03710	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MKL45_03730	COG0583	DNA-binding transcription factor activity
MKL45_03750	COG0668	transmembrane transport
MKL45_03760	COG2081	HI0933 family
MKL45_03765	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MKL45_03795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKL45_03795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKL45_03805	COG0489	protein tyrosine kinase activity
MKL45_03855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MKL45_03865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MKL45_03880	COG0730	response to heat
MKL45_03890	COG1196	nuclear chromosome segregation
MKL45_03910	COG2223	nitrite transmembrane transporter activity
MKL45_03915	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MKL45_03920	COG1877	trehalose-phosphatase activity
MKL45_03925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MKL45_03925	COG2226	methyltransferase
MKL45_03925	COG0596	Alpha beta hydrolase
MKL45_03940	COG4106	trans-aconitate 2-methyltransferase activity
MKL45_03955	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MKL45_03960	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MKL45_03965	COG0009	L-threonylcarbamoyladenylate synthase
MKL45_03970	COG3101	peptidyl-lysine hydroxylation
MKL45_03975	COG1399	metal-binding, possibly nucleic acid-binding protein
MKL45_04000	COG1652	LysM domain
MKL45_04005	COG0351	phosphomethylpyrimidine kinase
MKL45_04005	COG0352	thiamine-phosphate diphosphorylase activity
MKL45_04005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MKL45_04015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MKL45_04045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MKL45_04075	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MKL45_04090	COG0358	DNA primase activity
MKL45_04100	COG0564	pseudouridine synthase activity
MKL45_04125	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MKL45_04145	COG0583	DNA-binding transcription factor activity
MKL45_04150	COG0473	3-isopropylmalate dehydrogenase activity
MKL45_04160	COG0657	acetylesterase activity
MKL45_04170	COG1012	belongs to the aldehyde dehydrogenase family
MKL45_04190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MKL45_04190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MKL45_04205	COG1981	membrane
MKL45_04250	COG0456	acetyltransferase
MKL45_04260	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MKL45_04265	COG0492	ferredoxin-NADP+ reductase activity
MKL45_04270	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MKL45_04270	COG1674	ftsk spoiiie
MKL45_04275	COG1280	lysine exporter protein (LysE YggA)
MKL45_04290	COG2894	cell division
MKL45_04305	COG0204	Acyl-transferase
MKL45_04310	COG2885	chlorophyll binding
MKL45_04315	COG0210	DNA helicase
MKL45_04325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MKL45_04340	COG0121	glutamine amidotransferase
MKL45_04360	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MKL45_04365	COG0735	belongs to the Fur family
MKL45_04390	COG0420	3'-5' exonuclease activity
MKL45_04410	COG1090	epimerase
MKL45_04425	COG2050	protein possibly involved in aromatic compounds catabolism
MKL45_04435	COG2814	Major facilitator Superfamily
MKL45_04440	COG0405	Gamma-glutamyltransferase
MKL45_04480	COG1396	sequence-specific DNA binding
MKL45_04510	COG0477	Major facilitator Superfamily
MKL45_04515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MKL45_04540	COG0531	amino acid
MKL45_04545	COG2040	homocysteine
MKL45_04570	COG1309	transcriptional regulator
MKL45_04575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKL45_04580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKL45_04590	COG1607	acyl-coa hydrolase
MKL45_04600	COG0523	cobalamin synthesis protein
MKL45_04610	COG4681	YaeQ
MKL45_04620	COG1649	PFAM Uncharacterised BCR, COG1649
MKL45_04620	COG0726	polysaccharide deacetylase
MKL45_04625	COG1215	transferase activity, transferring glycosyl groups
MKL45_04635	COG1024	Enoyl-CoA hydratase
MKL45_04650	COG1414	Transcriptional regulator
MKL45_04670	COG1028	Short-chain dehydrogenase reductase Sdr
MKL45_04680	COG0446	pyridine nucleotide-disulphide oxidoreductase
MKL45_04685	COG2271	Major facilitator Superfamily
MKL45_04695	COG2267	carboxylic ester hydrolase activity
MKL45_04700	COG1028	Short-chain dehydrogenase reductase Sdr
MKL45_04715	COG0028	Belongs to the TPP enzyme family
MKL45_04725	COG0477	Major facilitator Superfamily
MKL45_04730	COG0242	peptide deformylase activity
MKL45_04735	COG2066	Belongs to the glutaminase family
MKL45_04740	COG2207	Transcriptional regulator
MKL45_04745	COG2223	nitrite transmembrane transporter activity
MKL45_04760	COG0583	DNA-binding transcription factor activity
MKL45_04765	COG1028	Short-chain dehydrogenase reductase Sdr
MKL45_04770	COG2271	Major facilitator Superfamily
MKL45_04775	COG3959	Transketolase, thiamine diphosphate binding domain
MKL45_04780	COG3958	Transketolase
MKL45_04820	COG0306	phosphate transporter
MKL45_04840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MKL45_04860	COG4771	TonB-dependent receptor
MKL45_04885	COG4181	ATPase activity
MKL45_04890	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MKL45_04920	COG0583	DNA-binding transcription factor activity
MKL45_04930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MKL45_04935	COG1773	rubredoxin
MKL45_04985	COG2851	Citrate transporter
MKL45_04990	COG1253	flavin adenine dinucleotide binding
MKL45_05030	COG0804	urea catabolic process
MKL45_05040	COG0830	nickel cation binding
MKL45_05055	COG0742	ribosomal rna small subunit methyltransferase
MKL45_05060	COG0768	penicillin binding
MKL45_05085	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MKL45_05090	COG2878	Part of a membrane complex involved in electron transport
MKL45_05095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MKL45_05105	COG3384	dioxygenase
MKL45_05130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MKL45_05170	COG0006	proline dipeptidase activity
MKL45_05175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MKL45_05180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MKL45_05200	COG1279	arginine transmembrane transporter activity
MKL45_05205	COG0583	DNA-binding transcription factor activity
MKL45_05245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MKL45_05250	COG1388	LysM domain
MKL45_05250	COG0741	lytic transglycosylase activity
MKL45_05250	COG1388	LysM domain
MKL45_05250	COG0741	lytic transglycosylase activity
MKL45_05260	COG4174	ABC transporter (Permease)
MKL45_05265	COG4239	(ABC) transporter, permease
MKL45_05270	COG4172	Belongs to the ABC transporter superfamily
MKL45_05290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MKL45_05300	COG4251	negative regulation of phosphorylation
MKL45_05300	COG5001	Diguanylate cyclase
MKL45_05300	COG2203	Gaf domain
MKL45_05300	COG3706	GGDEF domain
MKL45_05310	COG1902	pentaerythritol trinitrate reductase activity
MKL45_05310	COG0446	pyridine nucleotide-disulphide oxidoreductase
MKL45_05320	COG0457	Tetratricopeptide repeat
MKL45_05330	COG0251	oxidation-reduction process
MKL45_05340	COG0583	DNA-binding transcription factor activity
MKL45_05370	COG3209	COG3209 Rhs family protein
MKL45_05440	COG1113	amino acid transport
MKL45_05450	COG0531	amino acid
MKL45_05470	COG1012	belongs to the aldehyde dehydrogenase family
MKL45_05490	COG1113	amino acid transport
MKL45_05505	COG0697	spore germination
MKL45_05510	COG2721	sulfolactate sulfo-lyase activity
MKL45_05515	COG2271	Major facilitator Superfamily
MKL45_05520	COG4948	Mandelate Racemase Muconate Lactonizing
MKL45_05530	COG1012	belongs to the aldehyde dehydrogenase family
MKL45_05535	COG2186	Transcriptional regulator
MKL45_05560	COG1960	acyl-CoA dehydrogenase activity
MKL45_05570	COG1012	belongs to the aldehyde dehydrogenase family
MKL45_05575	COG1024	Enoyl-CoA hydratase
MKL45_05580	COG2814	Major facilitator Superfamily
MKL45_05595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MKL45_05610	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MKL45_05650	COG2207	Transcriptional regulator
MKL45_05655	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MKL45_05660	COG2072	flavoprotein involved in K transport
MKL45_05665	COG0300	oxidoreductase activity
MKL45_05675	COG1309	transcriptional regulator
MKL45_05680	COG1741	Belongs to the pirin family
MKL45_05695	COG2072	flavoprotein involved in K transport
MKL45_05705	COG2252	PERMEase
MKL45_05710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MKL45_05720	COG3038	cytochrome b561
MKL45_05730	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MKL45_05740	COG0527	aspartate kinase activity
MKL45_05880	COG5410	chromosome segregation
MKL45_05885	COG3567	Phage-associated protein, HI1409 family
MKL45_05900	COG3566	protein conserved in bacteria
MKL45_05960	COG2314	TM2 domain
MKL45_05985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MKL45_06015	COG2194	sulfuric ester hydrolase activity
MKL45_06020	COG0582	viral genome integration into host DNA
MKL45_06040	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MKL45_06055	COG0667	Aldo Keto reductase
MKL45_06070	COG1765	OsmC-like protein
MKL45_06085	COG0542	response to heat
MKL45_06120	COG2885	chlorophyll binding
MKL45_06130	COG0625	glutathione transferase activity
MKL45_06135	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MKL45_06155	COG3634	alkyl hydroperoxide reductase activity
MKL45_06165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MKL45_06180	COG1643	Atp-dependent helicase
MKL45_06195	COG2814	Major facilitator Superfamily
MKL45_06200	COG3135	benzoate transporter
MKL45_06205	COG1028	Short-chain dehydrogenase reductase Sdr
MKL45_06210	COG0633	Ferredoxin
MKL45_06210	COG0543	2 iron, 2 sulfur cluster binding
MKL45_06220	COG4638	Rieske (2fe-2S)
MKL45_06230	COG0583	DNA-binding transcription factor activity
MKL45_06280	COG1570	exodeoxyribonuclease VII activity
MKL45_06310	COG1280	lysine exporter protein (LysE YggA)
MKL45_06315	COG1278	Cold shock
MKL45_06350	COG2814	Major facilitator Superfamily
MKL45_06620	COG0517	IMP dehydrogenase activity
MKL45_06620	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MKL45_06625	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MKL45_06635	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MKL45_06640	COG1137	ATPase activity
MKL45_06645	COG1538	Outer membrane efflux protein
MKL45_06675	COG4122	O-methyltransferase activity
MKL45_06685	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MKL45_06700	COG1522	sequence-specific DNA binding
MKL45_06705	COG5006	permease, DMT superfamily
MKL45_06715	COG1560	Kdo2-lipid A biosynthetic process
MKL45_06730	COG2814	Major facilitator Superfamily
MKL45_06750	COG1250	3-hydroxyacyl-CoA dehydrogenase
MKL45_06890	COG0583	DNA-binding transcription factor activity
MKL45_06895	COG1914	H( )-stimulated, divalent metal cation uptake system
MKL45_06915	COG4770	biotin carboxylase activity
MKL45_06920	COG0038	chloride channel
MKL45_06925	COG2831	hemolysin activation secretion protein
MKL45_06930	COG3210	domain, Protein
MKL45_06955	COG2801	Transposase and inactivated derivatives
MKL45_06990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MKL45_06995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MKL45_07000	COG2271	Major facilitator Superfamily
MKL45_07005	COG0753	catalase activity
MKL45_07010	COG3038	cytochrome b561
MKL45_07030	COG2267	carboxylic ester hydrolase activity
MKL45_07035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MKL45_07040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKL45_07045	COG1012	belongs to the aldehyde dehydrogenase family
MKL45_07055	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MKL45_07065	COG1012	belongs to the aldehyde dehydrogenase family
MKL45_07070	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MKL45_07075	COG0583	DNA-binding transcription factor activity
MKL45_07085	COG1414	Transcriptional regulator
MKL45_07090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MKL45_07100	COG1840	ABC-type Fe3 transport system, periplasmic component
MKL45_07105	COG3842	ATPase activity
MKL45_07120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MKL45_07125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MKL45_07130	COG2814	Major facilitator Superfamily
MKL45_07135	COG1960	acyl-CoA dehydrogenase activity
MKL45_07150	COG1024	Enoyl-CoA hydratase
MKL45_07160	COG2814	Major facilitator Superfamily
MKL45_07170	COG0183	Belongs to the thiolase family
MKL45_07175	COG1250	3-hydroxyacyl-CoA dehydrogenase
MKL45_07180	COG1028	Short-chain dehydrogenase reductase Sdr
MKL45_07185	COG1024	Enoyl-CoA hydratase
MKL45_07190	COG1960	acyl-CoA dehydrogenase activity
MKL45_07195	COG2814	Major facilitator Superfamily
MKL45_07200	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MKL45_07205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MKL45_07215	COG2814	Major facilitator Superfamily
MKL45_07225	COG1960	acyl-CoA dehydrogenase activity
MKL45_07240	COG0583	DNA-binding transcription factor activity
MKL45_07250	COG4770	biotin carboxylase activity
MKL45_07255	COG1024	Enoyl-CoA hydratase
MKL45_07260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MKL45_07265	COG1960	acyl-CoA dehydrogenase activity
MKL45_07270	COG1309	transcriptional regulator
MKL45_07275	COG0318	PFAM AMP-dependent synthetase and ligase
MKL45_07295	COG0583	DNA-binding transcription factor activity
MKL45_07310	COG2801	Transposase and inactivated derivatives
MKL45_07375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MKL45_07395	COG0784	Response regulator, receiver
MKL45_07395	COG2205	protein histidine kinase activity
MKL45_07415	COG0765	amino acid transport
MKL45_07420	COG0765	amino acid transport
MKL45_07425	COG1126	abc transporter atp-binding protein
MKL45_07430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKL45_07435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKL45_07450	COG1280	lysine exporter protein (LysE YggA)
MKL45_07455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MKL45_07465	COG1045	serine acetyltransferase
MKL45_07480	COG0583	DNA-binding transcription factor activity
MKL45_07485	COG0625	glutathione transferase activity
MKL45_07490	COG0625	glutathione transferase activity
MKL45_07495	COG0583	DNA-binding transcription factor activity
MKL45_07505	COG1346	cytolysis
MKL45_07525	COG2814	Major facilitator Superfamily
MKL45_07535	COG0583	DNA-binding transcription factor activity
MKL45_07545	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
MKL45_07550	COG3052	prosthetic group binding
MKL45_07570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MKL45_07590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKL45_07600	COG1294	oxidase, subunit
MKL45_07605	COG1271	oxidase subunit
MKL45_07625	COG0477	Major facilitator Superfamily
MKL45_07635	COG4521	taurine ABC transporter
MKL45_07640	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MKL45_07645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MKL45_07650	COG2175	clavaminate synthase activity
MKL45_07660	COG1953	Uracil, thiamine, allantoin
MKL45_07670	COG0583	DNA-binding transcription factor activity
MKL45_07680	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MKL45_07695	COG0640	Transcriptional regulator
MKL45_07700	COG0798	PFAM Bile acid sodium symporter
MKL45_07705	COG0583	DNA-binding transcription factor activity
MKL45_07720	COG3634	alkyl hydroperoxide reductase activity
MKL45_07760	COG0436	Aminotransferase
MKL45_07770	COG0386	Belongs to the glutathione peroxidase family
MKL45_07810	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MKL45_07835	COG0012	GTP binding
MKL45_07840	COG2011	ABC-type metal ion transport system permease component
MKL45_07845	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MKL45_07855	COG1464	Belongs to the NlpA lipoprotein family
MKL45_07885	COG0765	amino acid transport
MKL45_07890	COG0765	amino acid transport
MKL45_07895	COG1126	abc transporter atp-binding protein
MKL45_07905	COG1522	sequence-specific DNA binding
MKL45_07920	COG1309	transcriptional regulator
MKL45_07940	COG0583	DNA-binding transcription factor activity
MKL45_07950	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MKL45_07960	COG0697	spore germination
MKL45_07995	COG3121	Chaperone
MKL45_08000	COG3539	Fimbrial protein
MKL45_08025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MKL45_08025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MKL45_08070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MKL45_08080	COG2353	YceI-like domain
MKL45_08090	COG3698	Phosphodiester glycosidase
MKL45_08105	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MKL45_08110	COG0506	proline dehydrogenase activity
MKL45_08110	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MKL45_08110	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MKL45_08120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MKL45_08125	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MKL45_08145	COG1132	(ABC) transporter
MKL45_08150	COG3122	Protein conserved in bacteria
MKL45_08155	COG3619	membrane
MKL45_08165	COG0640	Transcriptional regulator
MKL45_08175	COG2850	peptidyl-arginine hydroxylation
MKL45_08180	COG0424	maF-like protein
MKL45_08200	COG0191	fructose-bisphosphate aldolase activity
MKL45_08205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MKL45_08220	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MKL45_08230	COG1192	Involved in chromosome partitioning
MKL45_08235	COG1475	DNA binding
MKL45_08240	COG0811	peptide transport
MKL45_08250	COG1132	(ABC) transporter
MKL45_08255	COG1663	tetraacyldisaccharide 4'-kinase activity
MKL45_08275	COG0084	hydrolase, TatD family'
MKL45_08340	COG0776	regulation of translation
MKL45_08370	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MKL45_08375	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MKL45_08415	COG0339	signal peptide processing
MKL45_08425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKL45_08460	COG0702	epimerase
MKL45_08465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MKL45_08485	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MKL45_08515	COG0316	Belongs to the HesB IscA family
MKL45_08520	COG0822	iron-sulfur transferase activity
MKL45_08545	COG0776	regulation of translation
MKL45_08550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MKL45_08555	COG2207	Transcriptional regulator
MKL45_08560	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKL45_08565	COG1960	acyl-CoA dehydrogenase activity
MKL45_08585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MKL45_08605	COG4264	IucA IucC family
MKL45_08610	COG4264	IucA IucC family
MKL45_08620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MKL45_08650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MKL45_08665	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MKL45_08670	COG0406	alpha-ribazole phosphatase activity
MKL45_08685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MKL45_08690	COG0730	response to heat
MKL45_08710	COG4773	Receptor
MKL45_08715	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MKL45_08730	COG1131	(ABC) transporter
MKL45_08735	COG0842	Transport permease protein
MKL45_08740	COG0842	Transport permease protein
MKL45_08795	COG2226	methyltransferase
MKL45_08820	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MKL45_08855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MKL45_08865	COG0133	tryptophan synthase activity
MKL45_08880	COG3706	GGDEF domain
MKL45_08895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MKL45_08900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MKL45_08905	COG0022	dehydrogenase e1 component
MKL45_08910	COG0508	dehydrogenase complex catalyzes the overall conversion of
MKL45_08915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKL45_08925	COG1063	alcohol dehydrogenase
MKL45_08930	COG3781	membrane
MKL45_08940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MKL45_08940	COG3453	Protein conserved in bacteria
MKL45_08955	COG0730	response to heat
MKL45_08970	COG2207	Transcriptional regulator
MKL45_08970	COG3708	Transcriptional regulator
MKL45_08975	COG1733	regulation of RNA biosynthetic process
MKL45_08980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MKL45_08990	COG2188	Transcriptional regulator
MKL45_09005	COG4521	taurine ABC transporter
MKL45_09010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MKL45_09030	COG0477	Major facilitator Superfamily
MKL45_09040	COG1027	Aspartate ammonia-lyase
MKL45_09055	COG0583	DNA-binding transcription factor activity
MKL45_09060	COG0583	DNA-binding transcription factor activity
MKL45_09065	COG0183	Belongs to the thiolase family
MKL45_09070	COG2031	fatty acid transporter
MKL45_09085	COG0583	DNA-binding transcription factor activity
MKL45_09095	COG2610	gluconate transmembrane transporter activity
MKL45_09100	COG1028	Short-chain dehydrogenase reductase Sdr
MKL45_09105	COG2207	Transcriptional regulator
MKL45_09120	COG1028	Short-chain dehydrogenase reductase Sdr
MKL45_09130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MKL45_09145	COG0543	2 iron, 2 sulfur cluster binding
MKL45_09145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MKL45_09150	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
MKL45_09155	COG4638	Rieske (2fe-2S)
MKL45_09165	COG0725	ABC transporter, periplasmic molybdate-binding protein
MKL45_09170	COG4149	molybdate abc transporter
MKL45_09175	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MKL45_09180	COG1028	Short-chain dehydrogenase reductase Sdr
MKL45_09185	COG1535	isochorismatase
MKL45_09185	COG3433	isochorismatase activity
MKL45_09245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MKL45_09260	COG0753	catalase activity
MKL45_09270	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MKL45_09295	COG3539	Fimbrial protein
MKL45_09345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MKL45_09355	COG2072	flavoprotein involved in K transport
MKL45_09365	COG1538	Outer membrane efflux protein
MKL45_09370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKL45_09375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKL45_09380	COG0745	RESPONSE REGULATOR receiver
MKL45_09385	COG2205	protein histidine kinase activity
MKL45_09400	COG2207	Transcriptional regulator
MKL45_09415	COG1028	Short-chain dehydrogenase reductase Sdr
MKL45_09425	COG1073	alpha beta
MKL45_09455	COG2801	Transposase and inactivated derivatives
MKL45_09480	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MKL45_09560	COG1120	ATPase activity
MKL45_09565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKL45_09580	COG1064	alcohol dehydrogenase
MKL45_09585	COG2207	Transcriptional regulator
MKL45_09590	COG2084	Dehydrogenase
MKL45_09600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MKL45_09605	COG0583	DNA-binding transcription factor activity
MKL45_09615	COG0129	dihydroxy-acid dehydratase activity
MKL45_09620	COG1012	belongs to the aldehyde dehydrogenase family
MKL45_09650	COG0583	DNA-binding transcription factor activity
MKL45_09665	COG2188	Transcriptional regulator
MKL45_09735	COG1473	amidohydrolase
MKL45_09745	COG0475	glutathione-regulated potassium exporter activity
MKL45_09745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MKL45_09760	COG0583	DNA-binding transcription factor activity
MKL45_09765	COG1335	isochorismatase
MKL45_09775	COG1309	transcriptional regulator
MKL45_09805	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MKL45_09815	COG0446	pyridine nucleotide-disulphide oxidoreductase
MKL45_09815	COG1902	pentaerythritol trinitrate reductase activity
MKL45_09830	COG1012	belongs to the aldehyde dehydrogenase family
MKL45_09850	COG2186	Transcriptional regulator
MKL45_09860	COG0583	DNA-binding transcription factor activity
MKL45_09865	COG4948	Mandelate Racemase Muconate Lactonizing
MKL45_09870	COG4829	muconolactone delta-isomerase
MKL45_09880	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MKL45_09885	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MKL45_09890	COG0183	Belongs to the thiolase family
MKL45_09895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MKL45_09905	COG1012	belongs to the aldehyde dehydrogenase family
MKL45_09915	COG3733	amine oxidase
MKL45_09925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MKL45_09935	COG1028	Short-chain dehydrogenase reductase Sdr
MKL45_09945	COG4638	Rieske (2fe-2S)
MKL45_09965	COG0154	amidase activity
MKL45_09975	COG2814	Major facilitator Superfamily
MKL45_10000	COG1960	acyl-CoA dehydrogenase activity
MKL45_10005	COG0583	DNA-binding transcription factor activity
MKL45_10010	COG1414	Transcriptional regulator
MKL45_10025	COG2391	methyltransferase activity
MKL45_10035	COG4993	Dehydrogenase
MKL45_10040	COG3659	wide pore channel activity
MKL45_10045	COG3420	alginic acid biosynthetic process
MKL45_10050	COG0710	3-dehydroquinate dehydratase activity
MKL45_10055	COG3485	protocatechuate 3,4-dioxygenase
MKL45_10060	COG3485	protocatechuate 3,4-dioxygenase
MKL45_10065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MKL45_10070	COG2271	Major facilitator Superfamily
MKL45_10075	COG0596	Alpha beta hydrolase
MKL45_10080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MKL45_10085	COG0183	Belongs to the thiolase family
MKL45_10090	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MKL45_10095	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MKL45_10105	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MKL45_10110	COG2323	membrane
MKL45_10155	COG0446	pyridine nucleotide-disulphide oxidoreductase
MKL45_10155	COG1902	pentaerythritol trinitrate reductase activity
MKL45_10180	COG0542	response to heat
MKL45_10185	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MKL45_10215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MKL45_10220	COG0569	domain protein
MKL45_10225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MKL45_10240	COG4774	siderophore transport
MKL45_10245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKL45_10255	COG1585	Membrane protein implicated in regulation of membrane protease activity
MKL45_10270	COG1294	oxidase, subunit
MKL45_10275	COG4890	Cyd operon protein YbgT
MKL45_10290	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
MKL45_10300	COG0552	protein localization to endoplasmic reticulum
MKL45_10325	COG0516	GMP reductase activity
MKL45_10325	COG0517	IMP dehydrogenase activity
MKL45_10330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MKL45_10335	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MKL45_10345	COG0583	DNA-binding transcription factor activity
MKL45_10350	COG0024	Methionine aminopeptidase
MKL45_10380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MKL45_10380	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKL45_10385	COG1105	Belongs to the carbohydrate kinase PfkB family
MKL45_10390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKL45_10390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKL45_10390	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
MKL45_10405	COG5001	Diguanylate cyclase
MKL45_10405	COG3300	MHYT domain
MKL45_10420	COG2135	peptidase activity
MKL45_10425	COG0659	secondary active sulfate transmembrane transporter activity
MKL45_10445	COG1113	amino acid transport
MKL45_10455	COG1522	sequence-specific DNA binding
MKL45_10480	COG1011	Hydrolase
MKL45_10485	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MKL45_10495	COG2137	regulation of response to DNA damage stimulus
MKL45_10510	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MKL45_10530	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MKL45_10545	COG0575	Belongs to the CDS family
MKL45_10550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MKL45_10570	COG3852	Histidine kinase
MKL45_10575	COG2204	response regulator
MKL45_10630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MKL45_10635	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MKL45_10655	COG0697	spore germination
MKL45_10660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKL45_10670	COG0303	'Molybdopterin
MKL45_10675	COG0521	Mo-molybdopterin cofactor biosynthetic process
MKL45_10675	COG0315	cyclic pyranopterin monophosphate synthase activity
MKL45_10690	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MKL45_10695	COG0243	molybdopterin cofactor binding
MKL45_10705	COG0243	molybdopterin cofactor binding
MKL45_10710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MKL45_10715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MKL45_10715	COG2146	nitrite reductase [NAD(P)H] activity
MKL45_10725	COG0745	RESPONSE REGULATOR receiver
MKL45_10730	COG1116	anion transmembrane transporter activity
MKL45_10730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MKL45_10750	COG0511	ligase activity, forming carbon-carbon bonds
MKL45_10765	COG2814	Major facilitator Superfamily
MKL45_10785	COG0069	glutamate synthase activity
MKL45_10805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MKL45_10815	COG1454	alcohol dehydrogenase
MKL45_10820	COG0824	Thioesterase
MKL45_10830	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MKL45_10855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MKL45_10860	COG2030	dehydratase
MKL45_10870	COG0183	Belongs to the thiolase family
MKL45_10885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MKL45_10895	COG1522	sequence-specific DNA binding
MKL45_10900	COG3135	benzoate transporter
MKL45_10910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MKL45_10935	COG0589	response to stress
MKL45_10940	COG0488	(ABC) transporter
MKL45_10960	COG4773	Receptor
MKL45_10990	COG0668	transmembrane transport
MKL45_11000	COG1309	transcriptional regulator
MKL45_11010	COG2801	Transposase and inactivated derivatives
MKL45_11025	COG1605	Chorismate mutase
MKL45_11035	COG4221	oxidoreductase activity
MKL45_11065	COG0308	aminopeptidase N
MKL45_11090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MKL45_11095	COG1454	alcohol dehydrogenase
MKL45_11115	COG0531	amino acid
MKL45_11120	COG4303	Ethanolamine ammonia lyase large subunit
MKL45_11125	COG4302	ethanolamine ammonia-lyase activity
MKL45_11130	COG0519	Catalyzes the synthesis of GMP from XMP
MKL45_11130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MKL45_11135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MKL45_11160	COG0697	spore germination
MKL45_11165	COG1923	regulation of RNA biosynthetic process
MKL45_11175	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MKL45_11180	COG0802	atpase or kinase
MKL45_11200	COG1187	pseudouridine synthase activity
MKL45_11215	COG0583	DNA-binding transcription factor activity
MKL45_11230	COG2814	Major facilitator Superfamily
MKL45_11235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MKL45_11260	COG0729	surface antigen
MKL45_11280	COG0174	glutamine synthetase
MKL45_11285	COG0745	RESPONSE REGULATOR receiver
MKL45_11290	COG2205	protein histidine kinase activity
MKL45_11300	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MKL45_11305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MKL45_11330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MKL45_11335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MKL45_11340	COG1960	acyl-CoA dehydrogenase activity
MKL45_11370	COG0583	DNA-binding transcription factor activity
MKL45_11385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKL45_11395	COG3658	cytochrome
MKL45_11400	COG1215	transferase activity, transferring glycosyl groups
MKL45_11405	COG0726	polysaccharide deacetylase
MKL45_11405	COG1649	PFAM Uncharacterised BCR, COG1649
MKL45_11430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MKL45_11435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MKL45_11445	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MKL45_11470	COG0305	Participates in initiation and elongation during chromosome replication
MKL45_11475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MKL45_11485	COG1305	Transglutaminase-like
MKL45_11495	COG2308	Evidence 4 Homologs of previously reported genes of
MKL45_11525	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MKL45_11530	COG0138	bifunctional purine biosynthesis protein purh
MKL45_11535	COG0151	Belongs to the GarS family
MKL45_11540	COG1464	Belongs to the NlpA lipoprotein family
MKL45_11545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MKL45_11550	COG2011	ABC-type metal ion transport system permease component
MKL45_11555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MKL45_11565	COG1301	dicarboxylic acid transport
MKL45_11595	COG1794	racemase activity, acting on amino acids and derivatives
MKL45_11615	COG0745	RESPONSE REGULATOR receiver
MKL45_11620	COG0642	Histidine kinase
MKL45_11625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MKL45_11635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MKL45_11675	COG2351	hydroxyisourate hydrolase activity
MKL45_11685	COG3008	intermembrane lipid transfer
MKL45_11685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MKL45_11690	COG2995	paraquat-inducible protein a
MKL45_11715	COG2801	Transposase and inactivated derivatives
MKL45_11730	COG1051	belongs to the nudix hydrolase family
MKL45_11735	COG0477	Major facilitator Superfamily
MKL45_11785	COG2186	Transcriptional regulator
MKL45_11795	COG0786	glutamate:sodium symporter activity
MKL45_11800	COG3243	poly(R)-hydroxyalkanoic acid synthase
MKL45_11825	COG3111	PFAM Bacterial OB fold (BOF) protein
MKL45_11895	COG2831	hemolysin activation secretion protein
MKL45_11950	COG1610	YqeY-like protein
MKL45_11955	COG4783	chaperone-mediated protein folding
MKL45_11980	COG1286	toxin biosynthetic process
MKL45_12010	COG0778	Nitroreductase
MKL45_12020	COG0513	Belongs to the DEAD box helicase family
MKL45_12045	COG2363	Small membrane protein
MKL45_12075	COG1234	tRNA 3'-trailer cleavage
MKL45_12080	COG2195	Cleaves the N-terminal amino acid of tripeptides
MKL45_12090	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MKL45_12105	COG1960	acyl-CoA dehydrogenase activity
MKL45_12110	COG1301	dicarboxylic acid transport
MKL45_12115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MKL45_12120	COG3139	Protein of unknown function (DUF1315)
MKL45_12125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MKL45_12130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MKL45_12140	COG0494	nUDIX hydrolase
MKL45_12150	COG0642	Histidine kinase
MKL45_12165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MKL45_12175	COG1720	tRNA m6t6A37 methyltransferase activity
MKL45_12195	COG0826	peptidase U32
MKL45_12200	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MKL45_12215	COG4160	amino acid transport
MKL45_12220	COG4215	(ABC) transporter
MKL45_12235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKL45_12280	COG1131	(ABC) transporter
MKL45_12285	COG0842	Transport permease protein
MKL45_12300	COG0772	Belongs to the SEDS family
MKL45_12305	COG2951	lytic endotransglycosylase activity
MKL45_12330	COG2207	Transcriptional regulator
MKL45_12345	COG0052	Belongs to the universal ribosomal protein uS2 family
MKL45_12350	COG0024	Methionine aminopeptidase
MKL45_12360	COG2223	nitrite transmembrane transporter activity
MKL45_12370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKL45_12375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MKL45_12380	COG1960	acyl-CoA dehydrogenase activity
MKL45_12395	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MKL45_12400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MKL45_12405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MKL45_12425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKL45_12430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MKL45_12435	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MKL45_12470	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MKL45_12480	COG0174	glutamine synthetase
MKL45_12495	COG0512	Glutamine amidotransferase of anthranilate synthase
MKL45_12500	COG0308	aminopeptidase N
MKL45_12530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MKL45_12540	COG0302	gtp cyclohydrolase
MKL45_12560	COG3739	integral membrane protein
MKL45_12575	COG1169	isochorismate synthase
MKL45_12580	COG2977	Belongs to the P-Pant transferase superfamily
MKL45_12585	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
MKL45_12590	COG1132	(ABC) transporter
MKL45_12595	COG1132	(ABC) transporter
MKL45_12610	COG1535	isochorismatase
MKL45_12610	COG3433	isochorismatase activity
MKL45_12615	COG1021	2,3-dihydroxybenzoate-AMP ligase
MKL45_12620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MKL45_12630	COG4774	siderophore transport
MKL45_12635	COG4607	ABC-type enterochelin transport system periplasmic component
MKL45_12640	COG4604	ABC transporter, ATP-binding protein
MKL45_12645	COG4605	iron ion homeostasis
MKL45_12650	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKL45_12655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MKL45_12670	COG2964	Protein conserved in bacteria
MKL45_12680	COG1741	Belongs to the pirin family
MKL45_12695	COG2801	Transposase and inactivated derivatives
MKL45_12730	COG2879	small protein
MKL45_12735	COG1966	Carbon starvation protein
MKL45_12755	COG4943	cyclic-guanylate-specific phosphodiesterase activity
MKL45_12780	COG1067	ATP-dependent peptidase activity
MKL45_12785	COG0583	DNA-binding transcription factor activity
MKL45_12810	COG1686	Belongs to the peptidase S11 family
MKL45_12815	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MKL45_12850	COG0616	signal peptide processing
MKL45_12855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MKL45_12865	COG0573	inorganic phosphate transmembrane transporter activity
MKL45_12870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MKL45_12875	COG1113	amino acid transport
MKL45_12880	COG3961	Belongs to the TPP enzyme family
MKL45_12885	COG1522	sequence-specific DNA binding
MKL45_12895	COG0076	glutamate decarboxylase activity
MKL45_12900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MKL45_12925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MKL45_12960	COG0352	thiamine-phosphate diphosphorylase activity
MKL45_12985	COG0612	Peptidase, M16
MKL45_12995	COG1823	symporter activity
MKL45_13000	COG0583	DNA-binding transcription factor activity
MKL45_13005	COG0477	Major facilitator Superfamily
MKL45_13030	COG1187	pseudouridine synthase activity
MKL45_13045	COG1686	Belongs to the peptidase S11 family
MKL45_13050	COG1252	NADH dehydrogenase
MKL45_13060	COG0415	Belongs to the DNA photolyase family
MKL45_13075	COG1215	transferase activity, transferring glycosyl groups
MKL45_13105	COG2070	2-Nitropropane dioxygenase
MKL45_13160	COG0556	nucleotide-excision repair
MKL45_13180	COG0436	Aminotransferase
MKL45_13210	COG4221	oxidoreductase activity
MKL45_13220	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MKL45_13225	COG1381	Involved in DNA repair and RecF pathway recombination
MKL45_13235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MKL45_13250	COG0681	Belongs to the peptidase S26 family
MKL45_13265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKL45_13285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MKL45_13290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MKL45_13295	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MKL45_13305	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MKL45_13310	COG4208	sulfate ABC transporter
MKL45_13315	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MKL45_13320	COG0583	DNA-binding transcription factor activity
MKL45_13325	COG4625	pathogenesis
MKL45_13340	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MKL45_13355	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MKL45_13365	COG1056	cytidyltransferase-related domain
MKL45_13365	COG1051	belongs to the nudix hydrolase family
MKL45_13370	COG1024	Enoyl-CoA hydratase
MKL45_13385	COG2814	Major facilitator Superfamily
MKL45_13390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MKL45_13390	COG0047	phosphoribosylformylglycinamidine synthase activity
MKL45_13415	COG0824	Thioesterase
MKL45_13435	COG0823	Involved in the tonB-independent uptake of proteins
MKL45_13455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MKL45_13490	COG0628	permease
MKL45_13500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MKL45_13505	COG0596	Alpha beta hydrolase
MKL45_13510	COG0616	signal peptide processing
MKL45_13510	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MKL45_13520	COG2333	competence protein COMEC
MKL45_13520	COG0658	competence protein
MKL45_13525	COG1136	(ABC) transporter
MKL45_13530	COG4591	ABC-type transport system involved in lipoprotein release permease component
MKL45_13565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKL45_13585	COG0463	Glycosyl transferase, family 2
MKL45_13615	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MKL45_13620	COG1280	lysine exporter protein (LysE YggA)
MKL45_13625	COG2267	carboxylic ester hydrolase activity
MKL45_13635	COG0019	diaminopimelate decarboxylase activity
MKL45_13645	COG1113	amino acid transport
MKL45_13660	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MKL45_13670	COG3339	Conserved Protein
MKL45_13675	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MKL45_13680	COG0243	molybdopterin cofactor binding
MKL45_13685	COG1929	Belongs to the glycerate kinase type-1 family
MKL45_13700	COG0778	Nitroreductase
MKL45_13715	COG2801	Transposase and inactivated derivatives
MKL45_13745	COG3811	Belongs to the UPF0386 family
MKL45_13755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MKL45_13780	COG2059	Chromate
MKL45_13790	COG2015	COG2015, Alkyl sulfatase and related hydrolases
MKL45_13800	COG1230	cation diffusion facilitator family transporter
MKL45_13815	COG2814	Major facilitator Superfamily
MKL45_13880	COG3328	transposase activity
MKL45_13890	COG2801	Transposase and inactivated derivatives
MKL45_13945	COG0582	viral genome integration into host DNA
MKL45_13955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MKL45_13975	COG0741	lytic transglycosylase activity
MKL45_13995	COG0584	glycerophosphoryl diester phosphodiesterase
MKL45_14000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MKL45_14020	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MKL45_14025	COG1597	lipid kinase activity
MKL45_14040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MKL45_14045	COG0477	Major facilitator Superfamily
MKL45_14095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MKL45_14100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MKL45_14125	COG0505	Belongs to the CarA family
MKL45_14145	COG0589	response to stress
MKL45_14160	COG2843	Capsule synthesis protein
MKL45_14180	COG2321	neutral zinc metallopeptidase
MKL45_14185	COG2354	Protein conserved in bacteria
MKL45_14205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKL45_14230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MKL45_14235	COG1053	succinate dehydrogenase
MKL45_14240	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MKL45_14245	COG2009	succinate dehydrogenase
MKL45_14280	COG2921	Belongs to the UPF0250 family
MKL45_14285	COG0321	lipoyl(octanoyl) transferase activity
MKL45_14300	COG0531	amino acid
MKL45_14310	COG1733	regulation of RNA biosynthetic process
MKL45_14315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MKL45_14320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MKL45_14320	COG1648	precorrin-2 dehydrogenase activity
MKL45_14335	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MKL45_14365	COG0671	phosphoesterase, PA-phosphatase related
MKL45_14370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKL45_14380	COG1538	Outer membrane efflux protein
MKL45_14385	COG0393	Putative heavy-metal-binding
MKL45_14400	COG1028	Short-chain dehydrogenase reductase Sdr
MKL45_14410	COG0525	valine-tRNA ligase activity
MKL45_14430	COG0583	DNA-binding transcription factor activity
MKL45_14435	COG0004	ammonium transporteR
MKL45_14445	COG0642	Histidine kinase
MKL45_14450	COG0745	RESPONSE REGULATOR receiver
MKL45_14455	COG2194	sulfuric ester hydrolase activity
MKL45_14475	COG1752	Esterase of the alpha-beta hydrolase superfamily
MKL45_14490	COG2315	Protein conserved in bacteria
MKL45_14495	COG0142	geranyltranstransferase activity
MKL45_14500	COG2828	Protein conserved in bacteria
MKL45_14505	COG1113	amino acid transport
MKL45_14525	COG2207	Transcriptional regulator
MKL45_14550	COG2249	NAD(P)H dehydrogenase (quinone) activity
MKL45_14560	COG0560	Phosphoserine phosphatase
MKL45_14570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MKL45_14580	COG1530	ribonuclease E activity
MKL45_14585	COG0424	maF-like protein
MKL45_14590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MKL45_14595	COG1792	Involved in formation and maintenance of cell shape
MKL45_14600	COG1077	Cell shape determining protein MreB Mrl
MKL45_14605	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MKL45_14615	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MKL45_14640	COG3590	peptidase
MKL45_14645	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
MKL45_14655	COG1752	Esterase of the alpha-beta hydrolase superfamily
MKL45_14660	COG1115	amino acid carrier protein
MKL45_14680	COG2814	Major facilitator Superfamily
MKL45_14685	COG1289	transmembrane transporter activity
MKL45_14695	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MKL45_14735	COG1376	ErfK ybiS ycfS ynhG family protein
MKL45_14740	COG2832	Protein of unknown function (DUF454)
MKL45_14750	COG5510	response to toxic substance
MKL45_14775	COG0840	transmembrane signaling receptor activity
MKL45_14820	COG2824	Alkylphosphonate utilization operon protein PhnA
MKL45_14825	COG3189	MarR family transcriptional regulator
MKL45_14835	COG0354	folic acid binding
MKL45_14840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MKL45_14850	COG0679	Auxin Efflux Carrier
MKL45_14855	COG1902	pentaerythritol trinitrate reductase activity
MKL45_14860	COG4772	TonB-dependent receptor
MKL45_14865	COG2094	Belongs to the DNA glycosylase MPG family
MKL45_14890	COG1217	gtp-binding protein TYPA
MKL45_14895	COG2233	PERMEase
MKL45_14905	COG0833	amino acid
MKL45_14910	COG1690	Belongs to the RtcB family
MKL45_14920	COG2885	chlorophyll binding
MKL45_14920	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MKL45_14930	COG0183	Belongs to the thiolase family
MKL45_14950	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MKL45_14970	COG2207	Transcriptional regulator
MKL45_14975	COG0183	Belongs to the thiolase family
MKL45_15005	COG1272	protein, Hemolysin III
MKL45_15010	COG0477	Major facilitator Superfamily
MKL45_15025	COG0450	alkyl hydroperoxide reductase
MKL45_15045	COG0285	dihydrofolate synthase activity
MKL45_15095	COG2096	Adenosyltransferase
MKL45_15115	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MKL45_15120	COG0745	RESPONSE REGULATOR receiver
MKL45_15125	COG2205	protein histidine kinase activity
MKL45_15135	COG1960	acyl-CoA dehydrogenase activity
MKL45_15140	COG1960	acyl-CoA dehydrogenase activity
MKL45_15190	COG1215	transferase activity, transferring glycosyl groups
MKL45_15205	COG1091	dTDP-4-dehydrorhamnose reductase activity
MKL45_15220	COG0438	transferase activity, transferring glycosyl groups
MKL45_15225	COG0726	polysaccharide deacetylase
MKL45_15240	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MKL45_15245	COG2205	protein histidine kinase activity
MKL45_15275	COG1862	Preprotein translocase
MKL45_15285	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MKL45_15290	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MKL45_15300	COG3781	membrane
MKL45_15305	COG0613	PHP domain protein
MKL45_15315	COG2350	Protein conserved in bacteria
MKL45_15345	COG1607	acyl-coa hydrolase
MKL45_15405	COG2199	diguanylate cyclase activity
MKL45_15415	COG1408	metallophosphoesterase
MKL45_15420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MKL45_15430	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MKL45_15450	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MKL45_15455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MKL45_15470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MKL45_15480	COG2969	positive regulation of protein catabolic process
MKL45_15500	COG1960	acyl-CoA dehydrogenase activity
MKL45_15505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MKL45_15520	COG1309	transcriptional regulator
MKL45_15525	COG1960	acyl-CoA dehydrogenase activity
MKL45_15570	COG1183	phosphatidylcholine synthase activity
MKL45_15575	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MKL45_15605	COG0739	heme binding
MKL45_15605	COG0741	lytic transglycosylase activity
MKL45_15605	COG1196	nuclear chromosome segregation
MKL45_15615	COG1702	phosphate starvation-inducible protein PhoH
MKL45_15650	COG1295	ribonuclease BN
MKL45_15655	COG0697	spore germination
MKL45_15660	COG2169	Transcriptional regulator
MKL45_15665	COG0179	Fumarylacetoacetate (FAA) hydrolase
MKL45_15710	COG0557	exoribonuclease II activity
MKL45_15715	COG0339	signal peptide processing
MKL45_15720	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
MKL45_15750	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MKL45_15755	COG1960	acyl-CoA dehydrogenase activity
MKL45_15910	COG0626	cystathionine gamma-synthase activity
MKL45_15915	COG0433	COG0433 Predicted ATPase
MKL45_15925	COG1017	nitric oxide dioxygenase activity
MKL45_15925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MKL45_15930	COG1959	2 iron, 2 sulfur cluster binding
MKL45_15945	COG1301	dicarboxylic acid transport
MKL45_15950	COG1946	Acyl-CoA thioesterase
MKL45_15970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MKL45_15975	COG1040	competence protein
MKL45_15980	COG0494	nUDIX hydrolase
MKL45_15990	COG0598	Magnesium transport protein CorA
MKL45_16000	COG2854	intermembrane phospholipid transfer
MKL45_16010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MKL45_16015	COG1127	ABC transporter
MKL45_16025	COG0513	Belongs to the DEAD box helicase family
MKL45_16045	COG0408	coproporphyrinogen oxidase activity
MKL45_16060	COG1960	acyl-CoA dehydrogenase activity
MKL45_16070	COG1983	PspC domain protein
MKL45_16075	COG0517	IMP dehydrogenase activity
MKL45_16110	COG1106	Psort location Cytoplasmic, score
MKL45_16145	COG0583	DNA-binding transcription factor activity
MKL45_16185	COG1012	belongs to the aldehyde dehydrogenase family
MKL45_16195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MKL45_16200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MKL45_16205	COG0833	amino acid
MKL45_16235	COG1192	Involved in chromosome partitioning
MKL45_16240	COG0628	permease
MKL45_16250	COG1289	transmembrane transporter activity
MKL45_16265	COG2249	NAD(P)H dehydrogenase (quinone) activity
MKL45_16270	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
MKL45_16280	COG0277	FAD linked oxidase domain protein
MKL45_16285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MKL45_16310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MKL45_16315	COG5380	lipid catabolic process
MKL45_16335	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MKL45_16385	COG0194	GDP metabolic process
MKL45_16400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MKL45_16420	COG3307	-O-antigen
MKL45_16440	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MKL45_16445	COG1704	LemA family
MKL45_16455	COG0493	'glutamate synthase
MKL45_16460	COG0067	glutamate synthase
MKL45_16460	COG0069	glutamate synthase activity
MKL45_16460	COG0070	glutamate synthase
MKL45_16510	COG2226	methyltransferase
MKL45_16525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MKL45_16530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MKL45_16575	COG0833	amino acid
MKL45_16640	COG0488	(ABC) transporter
MKL45_16645	COG2873	o-acetylhomoserine
MKL45_16650	COG4221	oxidoreductase activity
MKL45_16655	COG0659	secondary active sulfate transmembrane transporter activity
MKL45_16680	COG0427	acetyl-CoA hydrolase
MKL45_16710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MKL45_16750	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MKL45_16815	COG2249	NAD(P)H dehydrogenase (quinone) activity
MKL45_16820	COG1733	regulation of RNA biosynthetic process
MKL45_16850	COG0667	Aldo Keto reductase
MKL45_16870	COG0583	DNA-binding transcription factor activity
MKL45_16875	COG2814	Major facilitator Superfamily
MKL45_16895	COG1309	transcriptional regulator
MKL45_16965	COG1335	isochorismatase
MKL45_16975	COG1012	belongs to the aldehyde dehydrogenase family
MKL45_16980	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MKL45_16990	COG1113	amino acid transport
MKL45_17000	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MKL45_17015	COG2814	Major facilitator Superfamily
MKL45_17025	COG0351	phosphomethylpyrimidine kinase
MKL45_17025	COG0352	thiamine-phosphate diphosphorylase activity
MKL45_17025	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MKL45_17045	COG1309	transcriptional regulator
MKL45_17050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MKL45_17065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKL45_17075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MKL45_17080	COG3162	membrane
MKL45_17085	COG2198	Histidine kinase
MKL45_17085	COG2205	protein histidine kinase activity
MKL45_17085	COG0784	Response regulator, receiver
MKL45_17110	COG1522	sequence-specific DNA binding
MKL45_17115	COG1335	isochorismatase
MKL45_17120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MKL45_17130	COG0668	transmembrane transport
MKL45_17135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MKL45_17140	COG1519	Transferase
MKL45_17145	COG1902	pentaerythritol trinitrate reductase activity
MKL45_17165	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MKL45_17190	COG0426	domain, Protein
MKL45_17190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MKL45_17195	COG4774	siderophore transport
MKL45_17200	COG2119	membrane
MKL45_17210	COG0508	dehydrogenase complex catalyzes the overall conversion of
MKL45_17220	COG4942	peptidase
MKL45_17235	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MKL45_17245	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MKL45_17265	COG0189	ligase activity
MKL45_17295	COG0708	Exodeoxyribonuclease III
MKL45_17300	COG1393	Belongs to the ArsC family
MKL45_17315	COG3706	GGDEF domain
MKL45_17350	COG2351	hydroxyisourate hydrolase activity
MKL45_17355	COG2233	PERMEase
MKL45_17365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MKL45_17375	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
MKL45_17380	COG1028	Short-chain dehydrogenase reductase Sdr
MKL45_17390	COG3150	esterase
MKL45_17435	COG3409	Peptidoglycan-binding domain 1 protein
MKL45_17435	COG1388	LysM domain
MKL45_17435	COG5632	N-Acetylmuramoyl-L-alanine amidase
MKL45_17450	COG2918	glutathione biosynthetic process
MKL45_17465	COG2733	membrane
MKL45_17470	COG0436	Aminotransferase
MKL45_17475	COG0534	Mate efflux family protein
MKL45_17560	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MKL45_17565	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MKL45_17575	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MKL45_17635	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MKL45_17650	COG0010	Belongs to the arginase family
MKL45_17680	COG2188	Transcriptional regulator
MKL45_17690	COG0523	cobalamin synthesis protein
MKL45_17700	COG1113	amino acid transport
MKL45_17710	COG0625	glutathione transferase activity
MKL45_17730	COG1683	Conserved Protein
MKL45_17735	COG0534	Mate efflux family protein
MKL45_17740	COG0385	Bile acid
MKL45_17745	COG1335	isochorismatase
MKL45_17750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MKL45_17770	COG2116	formate transmembrane transporter activity
MKL45_17775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MKL45_17780	COG2133	pyrroloquinoline quinone binding
MKL45_17785	COG2983	Belongs to the UPF0260 family
MKL45_17805	COG1194	a g-specific adenine glycosylase
MKL45_17820	COG2818	Glycosylase
MKL45_17825	COG1064	alcohol dehydrogenase
MKL45_17830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKL45_17845	COG0583	DNA-binding transcription factor activity
MKL45_17850	COG0656	L-ascorbic acid biosynthetic process
MKL45_17855	COG2814	Major facilitator Superfamily
MKL45_17885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKL45_17890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKL45_17905	COG2233	PERMEase
MKL45_17910	COG0583	DNA-binding transcription factor activity
MKL45_17945	COG0733	neurotransmitter:sodium symporter activity
MKL45_17985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MKL45_17990	COG0657	acetylesterase activity
MKL45_18010	COG0583	DNA-binding transcription factor activity
MKL45_18045	COG2951	lytic endotransglycosylase activity
MKL45_18050	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MKL45_18065	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MKL45_18075	COG0671	phosphoesterase, PA-phosphatase related
MKL45_18080	COG0861	Integral membrane protein TerC family
MKL45_18090	COG0754	glutathionylspermidine amidase activity
MKL45_18100	COG0402	S-adenosylhomocysteine deaminase activity
MKL45_18115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MKL45_18120	COG1230	cation diffusion facilitator family transporter
MKL45_18135	COG0706	membrane insertase activity
MKL45_18155	COG1192	Involved in chromosome partitioning
MKL45_18160	COG1475	DNA binding
MKL45_18315	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
MKL45_18340	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MKL45_18345	COG3657	addiction module killer protein
MKL45_18370	COG1063	alcohol dehydrogenase
MKL45_18380	COG3328	transposase activity
MKL45_18405	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MKL45_18415	COG1979	alcohol dehydrogenase
MKL45_18425	COG1902	pentaerythritol trinitrate reductase activity
MKL45_18435	COG1309	transcriptional regulator
MKL45_18440	COG2130	NADP-dependent
MKL45_18455	COG0582	viral genome integration into host DNA
MKL45_18460	COG3328	transposase activity
MKL45_18465	COG3328	transposase activity
MKL45_18505	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MKL45_18565	COG0358	DNA primase activity
MKL45_18690	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MKL45_18770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MKL45_18815	COG0071	Belongs to the small heat shock protein (HSP20) family
MKL45_18820	COG0542	response to heat
MKL45_18865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKL45_18870	COG0501	Belongs to the peptidase M48B family
MKL45_18905	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MKL45_18925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKL45_18935	COG5002	protein histidine kinase activity
MKL45_18940	COG0745	RESPONSE REGULATOR receiver
MKL45_18980	COG3173	Aminoglycoside phosphotransferase
MKL45_18985	COG0488	(ABC) transporter
MKL45_18990	COG3077	Addiction module antitoxin, RelB DinJ family
MKL45_19015	COG1660	Displays ATPase and GTPase activities
MKL45_19050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MKL45_19205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MKL45_19210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MKL45_19235	COG0582	viral genome integration into host DNA
MKL45_19260	COG3621	Patatin-like phospholipase