locus-tag	class	description
K6I41_00010	COG0592	DNA-directed DNA polymerase activity
K6I41_00020	COG0187	DNA topoisomerase II activity
K6I41_00035	COG0488	(ABC) transporter
K6I41_00060	COG0596	Alpha beta hydrolase
K6I41_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K6I41_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6I41_00105	COG0733	neurotransmitter:sodium symporter activity
K6I41_00145	COG2233	PERMEase
K6I41_00160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6I41_00195	COG2814	Major facilitator Superfamily
K6I41_00200	COG0656	L-ascorbic acid biosynthetic process
K6I41_00205	COG0583	DNA-binding transcription factor activity
K6I41_00220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6I41_00225	COG1064	alcohol dehydrogenase
K6I41_00230	COG2818	Glycosylase
K6I41_00245	COG1194	a g-specific adenine glycosylase
K6I41_00260	COG5487	UPF0391 membrane protein
K6I41_00265	COG2983	Belongs to the UPF0260 family
K6I41_00270	COG2133	pyrroloquinoline quinone binding
K6I41_00275	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6I41_00280	COG2116	formate transmembrane transporter activity
K6I41_00300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6I41_00305	COG1335	isochorismatase
K6I41_00310	COG0385	Bile acid
K6I41_00315	COG0534	Mate efflux family protein
K6I41_00320	COG1683	Conserved Protein
K6I41_00335	COG0346	lactoylglutathione lyase activity
K6I41_00340	COG0625	glutathione transferase activity
K6I41_00350	COG1113	amino acid transport
K6I41_00360	COG0523	cobalamin synthesis protein
K6I41_00370	COG2188	Transcriptional regulator
K6I41_00400	COG0010	Belongs to the arginase family
K6I41_00410	COG0546	phosphoglycolate phosphatase activity
K6I41_00415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K6I41_00420	COG1280	lysine exporter protein (LysE YggA)
K6I41_00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K6I41_00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6I41_00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K6I41_00545	COG0534	Mate efflux family protein
K6I41_00550	COG0436	Aminotransferase
K6I41_00555	COG2733	membrane
K6I41_00570	COG2918	glutathione biosynthetic process
K6I41_00605	COG3150	esterase
K6I41_00615	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
K6I41_00625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6I41_00635	COG2233	PERMEase
K6I41_00640	COG2351	hydroxyisourate hydrolase activity
K6I41_00675	COG3706	GGDEF domain
K6I41_00690	COG1393	Belongs to the ArsC family
K6I41_00695	COG0708	Exodeoxyribonuclease III
K6I41_00715	COG0189	ligase activity
K6I41_00735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K6I41_00745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6I41_00760	COG4942	peptidase
K6I41_00770	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6I41_00780	COG2119	membrane
K6I41_00785	COG4774	siderophore transport
K6I41_00790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K6I41_00790	COG0426	domain, Protein
K6I41_00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6I41_00830	COG1902	pentaerythritol trinitrate reductase activity
K6I41_00835	COG1519	Transferase
K6I41_00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K6I41_00845	COG0668	transmembrane transport
K6I41_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6I41_00860	COG1335	isochorismatase
K6I41_00865	COG1522	sequence-specific DNA binding
K6I41_00890	COG0784	Response regulator, receiver
K6I41_00890	COG2205	protein histidine kinase activity
K6I41_00890	COG2198	Histidine kinase
K6I41_00895	COG3162	membrane
K6I41_00900	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6I41_00910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6I41_00930	COG1309	transcriptional regulator
K6I41_00950	COG4221	oxidoreductase activity
K6I41_00955	COG0789	Transcriptional regulator
K6I41_00960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K6I41_00960	COG0352	thiamine-phosphate diphosphorylase activity
K6I41_00960	COG0351	phosphomethylpyrimidine kinase
K6I41_00970	COG2814	Major facilitator Superfamily
K6I41_00975	COG0629	single-stranded DNA binding
K6I41_00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
K6I41_00995	COG1113	amino acid transport
K6I41_01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6I41_01010	COG1012	belongs to the aldehyde dehydrogenase family
K6I41_01020	COG1335	isochorismatase
K6I41_01060	COG2814	Major facilitator Superfamily
K6I41_01065	COG0583	DNA-binding transcription factor activity
K6I41_01090	COG1309	transcriptional regulator
K6I41_01130	COG0667	Aldo Keto reductase
K6I41_01170	COG1733	regulation of RNA biosynthetic process
K6I41_01175	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6I41_01185	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K6I41_01190	COG2207	Transcriptional regulator
K6I41_01245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6I41_01260	COG2329	Antibiotic biosynthesis monooxygenase
K6I41_01265	COG0697	spore germination
K6I41_01275	COG4619	ABC transporter
K6I41_01295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K6I41_01325	COG0427	acetyl-CoA hydrolase
K6I41_01350	COG0659	secondary active sulfate transmembrane transporter activity
K6I41_01355	COG4221	oxidoreductase activity
K6I41_01365	COG2814	Major facilitator Superfamily
K6I41_01375	COG2873	o-acetylhomoserine
K6I41_01380	COG0488	(ABC) transporter
K6I41_01445	COG0833	amino acid
K6I41_01500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K6I41_01505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6I41_01520	COG2226	methyltransferase
K6I41_01570	COG0070	glutamate synthase
K6I41_01570	COG0069	glutamate synthase activity
K6I41_01570	COG0067	glutamate synthase
K6I41_01575	COG0493	'glutamate synthase
K6I41_01585	COG1704	LemA family
K6I41_01590	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
K6I41_01605	COG3307	-O-antigen
K6I41_01625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6I41_01640	COG0194	GDP metabolic process
K6I41_01690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6I41_01700	COG0335	large ribosomal subunit rRNA binding
K6I41_01710	COG5380	lipid catabolic process
K6I41_01715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K6I41_01730	COG5006	permease, DMT superfamily
K6I41_01740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6I41_01745	COG0277	FAD linked oxidase domain protein
K6I41_01765	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K6I41_01770	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6I41_01790	COG1289	transmembrane transporter activity
K6I41_01800	COG0628	permease
K6I41_01805	COG1192	Involved in chromosome partitioning
K6I41_01835	COG0833	amino acid
K6I41_01840	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6I41_01845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6I41_01855	COG1012	belongs to the aldehyde dehydrogenase family
K6I41_01895	COG0583	DNA-binding transcription factor activity
K6I41_01925	COG0752	glycyl-tRNA synthetase alpha subunit
K6I41_01950	COG0517	IMP dehydrogenase activity
K6I41_01950	COG0617	tRNA 3'-terminal CCA addition
K6I41_01950	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K6I41_01955	COG1983	PspC domain protein
K6I41_01965	COG1960	acyl-CoA dehydrogenase activity
K6I41_01980	COG0408	coproporphyrinogen oxidase activity
K6I41_02000	COG0513	Belongs to the DEAD box helicase family
K6I41_02010	COG1127	ABC transporter
K6I41_02015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K6I41_02025	COG2854	intermembrane phospholipid transfer
K6I41_02035	COG0598	Magnesium transport protein CorA
K6I41_02045	COG0494	nUDIX hydrolase
K6I41_02050	COG1040	competence protein
K6I41_02055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6I41_02075	COG1946	Acyl-CoA thioesterase
K6I41_02080	COG1301	dicarboxylic acid transport
K6I41_02095	COG1959	2 iron, 2 sulfur cluster binding
K6I41_02100	COG1017	nitric oxide dioxygenase activity
K6I41_02100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6I41_02110	COG0433	COG0433 Predicted ATPase
K6I41_02115	COG0626	cystathionine gamma-synthase activity
K6I41_02130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6I41_02135	COG0088	Forms part of the polypeptide exit tunnel
K6I41_02155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K6I41_02270	COG1960	acyl-CoA dehydrogenase activity
K6I41_02275	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K6I41_02300	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
K6I41_02305	COG0339	signal peptide processing
K6I41_02310	COG0557	exoribonuclease II activity
K6I41_02360	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6I41_02365	COG1295	ribonuclease BN
K6I41_02400	COG1702	phosphate starvation-inducible protein PhoH
K6I41_02410	COG0739	heme binding
K6I41_02410	COG0741	lytic transglycosylase activity
K6I41_02410	COG1196	nuclear chromosome segregation
K6I41_02440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K6I41_02445	COG1183	phosphatidylcholine synthase activity
K6I41_02490	COG1960	acyl-CoA dehydrogenase activity
K6I41_02495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6I41_02500	COG1309	transcriptional regulator
K6I41_02515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6I41_02520	COG1960	acyl-CoA dehydrogenase activity
K6I41_02560	COG2969	positive regulation of protein catabolic process
K6I41_02570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K6I41_02575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K6I41_02580	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K6I41_02585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6I41_02590	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K6I41_02610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6I41_02620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6I41_02625	COG1408	metallophosphoesterase
K6I41_02630	COG2885	chlorophyll binding
K6I41_02635	COG2199	diguanylate cyclase activity
K6I41_02670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6I41_02695	COG1607	acyl-coa hydrolase
K6I41_02730	COG2350	Protein conserved in bacteria
K6I41_02740	COG0613	PHP domain protein
K6I41_02745	COG3781	membrane
K6I41_02755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K6I41_02770	COG1862	Preprotein translocase
K6I41_02805	COG3850	Histidine kinase
K6I41_02805	COG2205	protein histidine kinase activity
K6I41_02805	COG3437	response regulator, receiver
K6I41_02805	COG4999	Histidine kinase
K6I41_02810	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K6I41_02830	COG0726	polysaccharide deacetylase
K6I41_02835	COG0463	Glycosyl transferase, family 2
K6I41_02840	COG0438	transferase activity, transferring glycosyl groups
K6I41_02870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K6I41_02905	COG1960	acyl-CoA dehydrogenase activity
K6I41_02910	COG1960	acyl-CoA dehydrogenase activity
K6I41_02920	COG2205	protein histidine kinase activity
K6I41_02925	COG0745	RESPONSE REGULATOR receiver
K6I41_02935	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K6I41_02955	COG2096	Adenosyltransferase
K6I41_02960	COG4206	TonB-dependent receptor
K6I41_03005	COG0285	dihydrofolate synthase activity
K6I41_03025	COG0450	alkyl hydroperoxide reductase
K6I41_03040	COG0477	Major facilitator Superfamily
K6I41_03045	COG1272	protein, Hemolysin III
K6I41_03055	COG2153	protein acetylation
K6I41_03075	COG0183	Belongs to the thiolase family
K6I41_03080	COG2207	Transcriptional regulator
K6I41_03100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6I41_03115	COG0183	Belongs to the thiolase family
K6I41_03125	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6I41_03125	COG2885	chlorophyll binding
K6I41_03135	COG1690	Belongs to the RtcB family
K6I41_03140	COG0833	amino acid
K6I41_03150	COG2233	PERMEase
K6I41_03155	COG1217	gtp-binding protein TYPA
K6I41_03170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6I41_03180	COG2094	Belongs to the DNA glycosylase MPG family
K6I41_03185	COG4772	TonB-dependent receptor
K6I41_03190	COG1902	pentaerythritol trinitrate reductase activity
K6I41_03205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6I41_03210	COG0354	folic acid binding
K6I41_03220	COG3189	MarR family transcriptional regulator
K6I41_03225	COG2824	Alkylphosphonate utilization operon protein PhnA
K6I41_03230	COG3422	double-strand break repair
K6I41_03270	COG0840	transmembrane signaling receptor activity
K6I41_03300	COG2832	Protein of unknown function (DUF454)
K6I41_03305	COG1376	ErfK ybiS ycfS ynhG family protein
K6I41_03345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6I41_03355	COG1289	transmembrane transporter activity
K6I41_03360	COG2814	Major facilitator Superfamily
K6I41_03380	COG1115	amino acid carrier protein
K6I41_03385	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6I41_03390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K6I41_03395	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
K6I41_03435	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K6I41_03445	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K6I41_03450	COG1077	Cell shape determining protein MreB Mrl
K6I41_03455	COG1792	Involved in formation and maintenance of cell shape
K6I41_03460	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K6I41_03465	COG0424	maF-like protein
K6I41_03470	COG1530	ribonuclease E activity
K6I41_03480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6I41_03525	COG2207	Transcriptional regulator
K6I41_03580	COG1113	amino acid transport
K6I41_03585	COG2828	Protein conserved in bacteria
K6I41_03590	COG0142	geranyltranstransferase activity
K6I41_03595	COG2315	Protein conserved in bacteria
K6I41_03610	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6I41_03635	COG2194	sulfuric ester hydrolase activity
K6I41_03640	COG0745	RESPONSE REGULATOR receiver
K6I41_03645	COG0642	Histidine kinase
K6I41_03655	COG0004	ammonium transporteR
K6I41_03660	COG0583	DNA-binding transcription factor activity
K6I41_03685	COG0525	valine-tRNA ligase activity
K6I41_03695	COG0525	valine-tRNA ligase activity
K6I41_03705	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_03715	COG0393	Putative heavy-metal-binding
K6I41_03720	COG0393	Putative heavy-metal-binding
K6I41_03725	COG1538	Outer membrane efflux protein
K6I41_03735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6I41_03740	COG0671	phosphoesterase, PA-phosphatase related
K6I41_03765	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K6I41_03780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K6I41_03780	COG1648	precorrin-2 dehydrogenase activity
K6I41_03785	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K6I41_03820	COG0531	amino acid
K6I41_03835	COG0321	lipoyl(octanoyl) transferase activity
K6I41_03840	COG2921	Belongs to the UPF0250 family
K6I41_03880	COG2009	succinate dehydrogenase
K6I41_03885	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K6I41_03890	COG1053	succinate dehydrogenase
K6I41_03895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6I41_03920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6I41_03940	COG2354	Protein conserved in bacteria
K6I41_03945	COG2321	neutral zinc metallopeptidase
K6I41_03965	COG2843	Capsule synthesis protein
K6I41_03980	COG0589	response to stress
K6I41_03985	COG0110	maltose O-acetyltransferase activity
K6I41_04000	COG0505	Belongs to the CarA family
K6I41_04030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6I41_04035	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K6I41_04080	COG0477	Major facilitator Superfamily
K6I41_04085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K6I41_04100	COG1597	lipid kinase activity
K6I41_04105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K6I41_04130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6I41_04135	COG0584	glycerophosphoryl diester phosphodiesterase
K6I41_04155	COG0741	lytic transglycosylase activity
K6I41_04175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6I41_04195	COG0583	DNA-binding transcription factor activity
K6I41_04200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6I41_04225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6I41_04235	COG0778	Nitroreductase
K6I41_04250	COG1929	Belongs to the glycerate kinase type-1 family
K6I41_04260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6I41_04290	COG1113	amino acid transport
K6I41_04300	COG0019	diaminopimelate decarboxylase activity
K6I41_04315	COG1280	lysine exporter protein (LysE YggA)
K6I41_04320	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K6I41_04345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6I41_04365	COG0463	Glycosyl transferase, family 2
K6I41_04385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6I41_04410	COG0697	spore germination
K6I41_04415	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6I41_04420	COG1136	(ABC) transporter
K6I41_04425	COG2333	competence protein COMEC
K6I41_04425	COG0658	competence protein
K6I41_04435	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6I41_04435	COG0616	signal peptide processing
K6I41_04445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6I41_04455	COG0628	permease
K6I41_04490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6I41_04510	COG0823	Involved in the tonB-independent uptake of proteins
K6I41_04530	COG0824	Thioesterase
K6I41_04535	COG1473	amidohydrolase
K6I41_04555	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6I41_04555	COG0047	phosphoribosylformylglycinamidine synthase activity
K6I41_04560	COG2814	Major facilitator Superfamily
K6I41_04565	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6I41_04570	COG1024	Enoyl-CoA hydratase
K6I41_04575	COG1056	cytidyltransferase-related domain
K6I41_04575	COG1051	belongs to the nudix hydrolase family
K6I41_04600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6I41_04615	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K6I41_04620	COG0602	queuosine metabolic process
K6I41_04630	COG4625	pathogenesis
K6I41_04635	COG0583	DNA-binding transcription factor activity
K6I41_04640	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K6I41_04645	COG4208	sulfate ABC transporter
K6I41_04650	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
K6I41_04660	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
K6I41_04665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6I41_04670	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6I41_04690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6I41_04700	COG0481	GTPase activity
K6I41_04705	COG0681	Belongs to the peptidase S26 family
K6I41_04715	COG0571	ribonuclease III activity
K6I41_04720	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6I41_04735	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K6I41_04745	COG4221	oxidoreductase activity
K6I41_04775	COG0436	Aminotransferase
K6I41_04795	COG0556	nucleotide-excision repair
K6I41_04850	COG2070	2-Nitropropane dioxygenase
K6I41_04865	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K6I41_04880	COG1215	transferase activity, transferring glycosyl groups
K6I41_04895	COG0415	Belongs to the DNA photolyase family
K6I41_04905	COG1252	NADH dehydrogenase
K6I41_04910	COG1686	Belongs to the peptidase S11 family
K6I41_04925	COG1187	pseudouridine synthase activity
K6I41_04940	COG0477	Major facilitator Superfamily
K6I41_04945	COG0583	DNA-binding transcription factor activity
K6I41_04950	COG1823	symporter activity
K6I41_04960	COG0612	Peptidase, M16
K6I41_04985	COG0352	thiamine-phosphate diphosphorylase activity
K6I41_05020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6I41_05045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6I41_05050	COG0076	glutamate decarboxylase activity
K6I41_05060	COG1522	sequence-specific DNA binding
K6I41_05065	COG3961	Belongs to the TPP enzyme family
K6I41_05070	COG1113	amino acid transport
K6I41_05075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K6I41_05080	COG0573	inorganic phosphate transmembrane transporter activity
K6I41_05090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6I41_05095	COG0616	signal peptide processing
K6I41_05135	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6I41_05140	COG1686	Belongs to the peptidase S11 family
K6I41_05165	COG0583	DNA-binding transcription factor activity
K6I41_05170	COG1067	ATP-dependent peptidase activity
K6I41_05210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K6I41_05215	COG1966	Carbon starvation protein
K6I41_05220	COG2879	small protein
K6I41_05235	COG1024	Enoyl-CoA hydratase
K6I41_05245	COG1960	acyl-CoA dehydrogenase activity
K6I41_05255	COG0318	PFAM AMP-dependent synthetase and ligase
K6I41_05330	COG2423	ornithine cyclodeaminase activity
K6I41_05350	COG1741	Belongs to the pirin family
K6I41_05365	COG3739	integral membrane protein
K6I41_05385	COG0302	gtp cyclohydrolase
K6I41_05395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K6I41_05430	COG0512	Glutamine amidotransferase of anthranilate synthase
K6I41_05445	COG0174	glutamine synthetase
K6I41_05455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K6I41_05490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K6I41_05495	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6I41_05500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6I41_05510	COG0281	malic enzyme
K6I41_05510	COG0280	phosphate acetyltransferase
K6I41_05520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K6I41_05525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6I41_05530	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K6I41_05545	COG1960	acyl-CoA dehydrogenase activity
K6I41_05550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K6I41_05555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6I41_05565	COG2223	nitrite transmembrane transporter activity
K6I41_05575	COG0024	Methionine aminopeptidase
K6I41_05580	COG0052	Belongs to the universal ribosomal protein uS2 family
K6I41_05595	COG2207	Transcriptional regulator
K6I41_05620	COG2951	lytic endotransglycosylase activity
K6I41_05625	COG0772	Belongs to the SEDS family
K6I41_05640	COG0842	Transport permease protein
K6I41_05645	COG1131	(ABC) transporter
K6I41_05685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6I41_05700	COG4215	(ABC) transporter
K6I41_05705	COG4160	amino acid transport
K6I41_05710	COG4598	ABC transporter
K6I41_05720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6I41_05725	COG0826	peptidase U32
K6I41_05730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6I41_05735	COG0384	phenazine biosynthesis protein PhzF
K6I41_05745	COG1720	tRNA m6t6A37 methyltransferase activity
K6I41_05755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6I41_05770	COG0642	Histidine kinase
K6I41_05780	COG0494	nUDIX hydrolase
K6I41_05790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6I41_05795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6I41_05800	COG3139	Protein of unknown function (DUF1315)
K6I41_05810	COG1301	dicarboxylic acid transport
K6I41_05815	COG1960	acyl-CoA dehydrogenase activity
K6I41_05825	COG2819	hydrolase of the alpha beta superfamily
K6I41_05835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K6I41_05845	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6I41_05865	COG1690	Belongs to the RtcB family
K6I41_05870	COG1234	tRNA 3'-trailer cleavage
K6I41_05875	COG4650	regulator
K6I41_05900	COG2363	Small membrane protein
K6I41_05920	COG0513	Belongs to the DEAD box helicase family
K6I41_05930	COG0778	Nitroreductase
K6I41_05960	COG1286	toxin biosynthetic process
K6I41_05985	COG4783	chaperone-mediated protein folding
K6I41_05990	COG1610	YqeY-like protein
K6I41_06020	COG2815	serine threonine protein kinase
K6I41_06020	COG0515	serine threonine protein kinase
K6I41_06045	COG1278	Cold shock
K6I41_06065	COG0786	glutamate:sodium symporter activity
K6I41_06070	COG0475	glutathione-regulated potassium exporter activity
K6I41_06070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6I41_06075	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_06105	COG2985	domain, Protein
K6I41_06115	COG2995	paraquat-inducible protein a
K6I41_06120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6I41_06120	COG3008	intermembrane lipid transfer
K6I41_06130	COG2351	hydroxyisourate hydrolase activity
K6I41_06170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K6I41_06180	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K6I41_06185	COG0642	Histidine kinase
K6I41_06190	COG0745	RESPONSE REGULATOR receiver
K6I41_06205	COG1794	racemase activity, acting on amino acids and derivatives
K6I41_06215	COG2175	clavaminate synthase activity
K6I41_06220	COG3246	L-lysine catabolic process to acetate
K6I41_06225	COG2814	Major facilitator Superfamily
K6I41_06240	COG2855	membrane
K6I41_06275	COG2814	Major facilitator Superfamily
K6I41_06290	COG0625	glutathione transferase activity
K6I41_06305	COG1301	dicarboxylic acid transport
K6I41_06320	COG2011	ABC-type metal ion transport system permease component
K6I41_06325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K6I41_06330	COG1464	Belongs to the NlpA lipoprotein family
K6I41_06335	COG0151	Belongs to the GarS family
K6I41_06345	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K6I41_06375	COG2308	Evidence 4 Homologs of previously reported genes of
K6I41_06385	COG1305	Transglutaminase-like
K6I41_06395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6I41_06400	COG0305	Participates in initiation and elongation during chromosome replication
K6I41_06425	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K6I41_06435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K6I41_06440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K6I41_06465	COG1649	PFAM Uncharacterised BCR, COG1649
K6I41_06465	COG0726	polysaccharide deacetylase
K6I41_06470	COG1215	transferase activity, transferring glycosyl groups
K6I41_06475	COG3658	cytochrome
K6I41_06485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6I41_06510	COG2890	protein-(glutamine-N5) methyltransferase activity
K6I41_06515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6I41_06520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6I41_06535	COG1960	acyl-CoA dehydrogenase activity
K6I41_06540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K6I41_06555	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K6I41_06565	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K6I41_06570	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K6I41_06575	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K6I41_06580	COG2205	protein histidine kinase activity
K6I41_06585	COG0745	RESPONSE REGULATOR receiver
K6I41_06590	COG0174	glutamine synthetase
K6I41_06605	COG0477	Major facilitator Superfamily
K6I41_06610	COG0729	surface antigen
K6I41_06640	COG0471	metal ion transport
K6I41_06650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6I41_06655	COG2814	Major facilitator Superfamily
K6I41_06670	COG0583	DNA-binding transcription factor activity
K6I41_06685	COG1187	pseudouridine synthase activity
K6I41_06705	COG0802	atpase or kinase
K6I41_06710	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6I41_06720	COG1923	regulation of RNA biosynthetic process
K6I41_06725	COG0697	spore germination
K6I41_06750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6I41_06755	COG0519	Catalyzes the synthesis of GMP from XMP
K6I41_06755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K6I41_06760	COG4302	ethanolamine ammonia-lyase activity
K6I41_06765	COG4303	Ethanolamine ammonia lyase large subunit
K6I41_06770	COG0531	amino acid
K6I41_06790	COG1454	alcohol dehydrogenase
K6I41_06795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6I41_06805	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
K6I41_06825	COG0308	aminopeptidase N
K6I41_06865	COG1605	Chorismate mutase
K6I41_06880	COG4772	TonB-dependent receptor
K6I41_06930	COG1733	regulation of RNA biosynthetic process
K6I41_06945	COG0583	DNA-binding transcription factor activity
K6I41_06960	COG3111	PFAM Bacterial OB fold (BOF) protein
K6I41_06980	COG0488	(ABC) transporter
K6I41_06985	COG0589	response to stress
K6I41_07005	COG3135	benzoate transporter
K6I41_07010	COG1522	sequence-specific DNA binding
K6I41_07020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6I41_07025	COG0583	DNA-binding transcription factor activity
K6I41_07035	COG0183	Belongs to the thiolase family
K6I41_07040	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_07045	COG2030	dehydratase
K6I41_07050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K6I41_07075	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K6I41_07085	COG0824	Thioesterase
K6I41_07090	COG1454	alcohol dehydrogenase
K6I41_07110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6I41_07140	COG0069	glutamate synthase activity
K6I41_07170	COG2814	Major facilitator Superfamily
K6I41_07185	COG0511	ligase activity, forming carbon-carbon bonds
K6I41_07210	COG4264	IucA IucC family
K6I41_07220	COG4264	IucA IucC family
K6I41_07225	COG2423	ornithine cyclodeaminase activity
K6I41_07230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6I41_07240	COG1116	anion transmembrane transporter activity
K6I41_07240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6I41_07245	COG0745	RESPONSE REGULATOR receiver
K6I41_07255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6I41_07255	COG2146	nitrite reductase [NAD(P)H] activity
K6I41_07260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6I41_07265	COG0243	molybdopterin cofactor binding
K6I41_07275	COG0243	molybdopterin cofactor binding
K6I41_07280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K6I41_07295	COG0315	cyclic pyranopterin monophosphate synthase activity
K6I41_07295	COG0521	Mo-molybdopterin cofactor biosynthetic process
K6I41_07300	COG0303	'Molybdopterin
K6I41_07310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6I41_07315	COG0697	spore germination
K6I41_07340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K6I41_07360	COG1335	isochorismatase
K6I41_07400	COG2204	response regulator
K6I41_07405	COG3852	Histidine kinase
K6I41_07430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K6I41_07435	COG0575	Belongs to the CDS family
K6I41_07450	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6I41_07470	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6I41_07485	COG2137	regulation of response to DNA damage stimulus
K6I41_07495	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6I41_07500	COG1011	Hydrolase
K6I41_07515	COG1522	sequence-specific DNA binding
K6I41_07525	COG1113	amino acid transport
K6I41_07545	COG0659	secondary active sulfate transmembrane transporter activity
K6I41_07565	COG5001	Diguanylate cyclase
K6I41_07565	COG3300	MHYT domain
K6I41_07580	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K6I41_07580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6I41_07580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6I41_07585	COG1105	Belongs to the carbohydrate kinase PfkB family
K6I41_07590	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6I41_07590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K6I41_07620	COG0024	Methionine aminopeptidase
K6I41_07625	COG0583	DNA-binding transcription factor activity
K6I41_07640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6I41_07645	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K6I41_07645	COG0517	IMP dehydrogenase activity
K6I41_07670	COG0552	protein localization to endoplasmic reticulum
K6I41_07695	COG4890	Cyd operon protein YbgT
K6I41_07700	COG1294	oxidase, subunit
K6I41_07715	COG1585	Membrane protein implicated in regulation of membrane protease activity
K6I41_07725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6I41_07730	COG4774	siderophore transport
K6I41_07745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6I41_07750	COG0569	domain protein
K6I41_07755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K6I41_07785	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K6I41_07790	COG0542	response to heat
K6I41_07800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6I41_07815	COG1902	pentaerythritol trinitrate reductase activity
K6I41_07815	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6I41_07855	COG0148	phosphopyruvate hydratase activity
K6I41_07860	COG2323	membrane
K6I41_07875	COG4773	Receptor
K6I41_07885	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K6I41_07895	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K6I41_07900	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K6I41_07905	COG0183	Belongs to the thiolase family
K6I41_07910	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K6I41_07915	COG0596	Alpha beta hydrolase
K6I41_07920	COG2271	Major facilitator Superfamily
K6I41_07925	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K6I41_07930	COG3485	protocatechuate 3,4-dioxygenase
K6I41_07935	COG3485	protocatechuate 3,4-dioxygenase
K6I41_07940	COG0710	3-dehydroquinate dehydratase activity
K6I41_07945	COG3420	alginic acid biosynthetic process
K6I41_07950	COG3659	wide pore channel activity
K6I41_07955	COG4993	Dehydrogenase
K6I41_07965	COG2391	methyltransferase activity
K6I41_07980	COG1414	Transcriptional regulator
K6I41_07985	COG0583	DNA-binding transcription factor activity
K6I41_07990	COG1960	acyl-CoA dehydrogenase activity
K6I41_08015	COG2814	Major facilitator Superfamily
K6I41_08025	COG0154	amidase activity
K6I41_08045	COG4638	Rieske (2fe-2S)
K6I41_08055	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_08065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K6I41_08075	COG3733	amine oxidase
K6I41_08090	COG1012	belongs to the aldehyde dehydrogenase family
K6I41_08095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K6I41_08100	COG0183	Belongs to the thiolase family
K6I41_08105	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K6I41_08110	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K6I41_08120	COG4829	muconolactone delta-isomerase
K6I41_08125	COG4948	Mandelate Racemase Muconate Lactonizing
K6I41_08130	COG0583	DNA-binding transcription factor activity
K6I41_08140	COG2186	Transcriptional regulator
K6I41_08160	COG1012	belongs to the aldehyde dehydrogenase family
K6I41_08170	COG2351	hydroxyisourate hydrolase activity
K6I41_08175	COG2233	PERMEase
K6I41_08185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6I41_08190	COG2186	Transcriptional regulator
K6I41_08200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6I41_08210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6I41_08220	COG0583	DNA-binding transcription factor activity
K6I41_08225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6I41_08230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6I41_08255	COG1079	Belongs to the binding-protein-dependent transport system permease family
K6I41_08275	COG3829	transcription factor binding
K6I41_08285	COG3829	transcription factor binding
K6I41_08290	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_08295	COG1414	Transcriptional regulator
K6I41_08300	COG1053	succinate dehydrogenase
K6I41_08315	COG3659	wide pore channel activity
K6I41_08320	COG1309	transcriptional regulator
K6I41_08325	COG0477	Major facilitator Superfamily
K6I41_08340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K6I41_08350	COG1053	succinate dehydrogenase
K6I41_08355	COG1053	succinate dehydrogenase
K6I41_08385	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K6I41_08420	COG1309	transcriptional regulator
K6I41_08435	COG4689	acetoacetate decarboxylase
K6I41_08445	COG1902	pentaerythritol trinitrate reductase activity
K6I41_08455	COG0604	alcohol dehydrogenase
K6I41_08455	COG4221	oxidoreductase activity
K6I41_08455	COG3321	synthase
K6I41_08455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6I41_08460	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_08480	COG0318	PFAM AMP-dependent synthetase and ligase
K6I41_08505	COG1902	pentaerythritol trinitrate reductase activity
K6I41_08515	COG1733	regulation of RNA biosynthetic process
K6I41_08520	COG0702	epimerase
K6I41_08530	COG0583	DNA-binding transcription factor activity
K6I41_08545	COG1309	transcriptional regulator
K6I41_08635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6I41_08640	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6I41_08685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6I41_08700	COG2271	Major facilitator Superfamily
K6I41_08710	COG1566	PFAM secretion protein HlyD family protein
K6I41_08725	COG1012	belongs to the aldehyde dehydrogenase family
K6I41_08730	COG0129	dihydroxy-acid dehydratase activity
K6I41_08740	COG0583	DNA-binding transcription factor activity
K6I41_08745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6I41_08755	COG2084	Dehydrogenase
K6I41_08760	COG2207	Transcriptional regulator
K6I41_08765	COG1064	alcohol dehydrogenase
K6I41_08785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6I41_08790	COG1120	ATPase activity
K6I41_08810	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6I41_08845	COG2197	response regulator
K6I41_08885	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K6I41_08925	COG1414	Transcriptional regulator
K6I41_08930	COG2851	Citrate transporter
K6I41_08940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6I41_08945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K6I41_08965	COG2259	Doxx family
K6I41_08970	COG0583	DNA-binding transcription factor activity
K6I41_08975	COG2205	protein histidine kinase activity
K6I41_08980	COG0745	RESPONSE REGULATOR receiver
K6I41_08985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6I41_08990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6I41_09005	COG4628	conserved protein (DUF2132)
K6I41_09015	COG2175	clavaminate synthase activity
K6I41_09020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6I41_09035	COG0667	Aldo Keto reductase
K6I41_09040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6I41_09055	COG2175	clavaminate synthase activity
K6I41_09085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6I41_09090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6I41_09095	COG4771	TonB-dependent receptor
K6I41_09125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6I41_09130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6I41_09135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6I41_09140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6I41_09155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6I41_09160	COG0805	protein transport
K6I41_09170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6I41_09190	COG1132	(ABC) transporter
K6I41_09195	COG1132	(ABC) transporter
K6I41_09215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6I41_09220	COG0601	transmembrane transport
K6I41_09250	COG3539	Fimbrial protein
K6I41_09275	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K6I41_09285	COG0753	catalase activity
K6I41_09305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6I41_09360	COG4771	TonB-dependent receptor
K6I41_09365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6I41_09370	COG1535	isochorismatase
K6I41_09370	COG3433	isochorismatase activity
K6I41_09375	COG1021	2,3-dihydroxybenzoate-AMP ligase
K6I41_09380	COG1169	isochorismate synthase
K6I41_09385	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_09395	COG3251	PFAM MbtH domain protein
K6I41_09400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6I41_09425	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K6I41_09430	COG4149	molybdate abc transporter
K6I41_09435	COG0725	ABC transporter, periplasmic molybdate-binding protein
K6I41_09445	COG4638	Rieske (2fe-2S)
K6I41_09450	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
K6I41_09455	COG0543	2 iron, 2 sulfur cluster binding
K6I41_09455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6I41_09470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K6I41_09480	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_09500	COG2207	Transcriptional regulator
K6I41_09505	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_09510	COG2610	gluconate transmembrane transporter activity
K6I41_09570	COG0583	DNA-binding transcription factor activity
K6I41_09585	COG2031	fatty acid transporter
K6I41_09590	COG0183	Belongs to the thiolase family
K6I41_09595	COG0583	DNA-binding transcription factor activity
K6I41_09600	COG0583	DNA-binding transcription factor activity
K6I41_09615	COG1027	Aspartate ammonia-lyase
K6I41_09625	COG0477	Major facilitator Superfamily
K6I41_09645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6I41_09650	COG4521	taurine ABC transporter
K6I41_09665	COG2188	Transcriptional regulator
K6I41_09670	COG3708	Transcriptional regulator
K6I41_09670	COG2207	Transcriptional regulator
K6I41_09685	COG0730	response to heat
K6I41_09705	COG3781	membrane
K6I41_09710	COG1063	alcohol dehydrogenase
K6I41_09720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6I41_09725	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6I41_09730	COG0022	dehydrogenase e1 component
K6I41_09735	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K6I41_09740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K6I41_09755	COG3706	GGDEF domain
K6I41_09775	COG0133	tryptophan synthase activity
K6I41_09785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6I41_09815	COG0583	DNA-binding transcription factor activity
K6I41_09820	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K6I41_09830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6I41_09895	COG0842	Transport permease protein
K6I41_09900	COG0842	Transport permease protein
K6I41_09905	COG1131	(ABC) transporter
K6I41_09920	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6I41_09925	COG4773	Receptor
K6I41_09945	COG0730	response to heat
K6I41_09950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6I41_09965	COG0406	alpha-ribazole phosphatase activity
K6I41_09970	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K6I41_09990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6I41_10005	COG1960	acyl-CoA dehydrogenase activity
K6I41_10010	COG1960	acyl-CoA dehydrogenase activity
K6I41_10015	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6I41_10020	COG2207	Transcriptional regulator
K6I41_10025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6I41_10030	COG0776	regulation of translation
K6I41_10055	COG0822	iron-sulfur transferase activity
K6I41_10060	COG0316	Belongs to the HesB IscA family
K6I41_10090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K6I41_10110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6I41_10115	COG0702	epimerase
K6I41_10155	COG0601	transmembrane transport
K6I41_10160	COG0339	signal peptide processing
K6I41_10165	COG4166	transmembrane transport
K6I41_10180	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K6I41_10205	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K6I41_10210	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K6I41_10225	COG2431	L-lysine efflux transmembrane transporter activity
K6I41_10240	COG0776	regulation of translation
K6I41_10305	COG0084	hydrolase, TatD family'
K6I41_10325	COG1663	tetraacyldisaccharide 4'-kinase activity
K6I41_10330	COG1132	(ABC) transporter
K6I41_10340	COG0811	peptide transport
K6I41_10345	COG1475	DNA binding
K6I41_10350	COG1192	Involved in chromosome partitioning
K6I41_10360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K6I41_10375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6I41_10380	COG0191	fructose-bisphosphate aldolase activity
K6I41_10400	COG0424	maF-like protein
K6I41_10405	COG2850	peptidyl-arginine hydroxylation
K6I41_10415	COG0640	Transcriptional regulator
K6I41_10425	COG3619	membrane
K6I41_10430	COG3122	Protein conserved in bacteria
K6I41_10435	COG1132	(ABC) transporter
K6I41_10455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K6I41_10460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6I41_10470	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
K6I41_10470	COG0506	proline dehydrogenase activity
K6I41_10470	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
K6I41_10475	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K6I41_10490	COG3698	Phosphodiester glycosidase
K6I41_10500	COG2353	YceI-like domain
K6I41_10510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6I41_10555	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K6I41_10555	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K6I41_10580	COG3539	Fimbrial protein
K6I41_10615	COG0583	DNA-binding transcription factor activity
K6I41_10620	COG0697	spore germination
K6I41_10630	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K6I41_10640	COG0583	DNA-binding transcription factor activity
K6I41_10655	COG1309	transcriptional regulator
K6I41_10670	COG1522	sequence-specific DNA binding
K6I41_10680	COG1126	abc transporter atp-binding protein
K6I41_10685	COG0765	amino acid transport
K6I41_10690	COG0765	amino acid transport
K6I41_10720	COG1464	Belongs to the NlpA lipoprotein family
K6I41_10730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K6I41_10735	COG2011	ABC-type metal ion transport system permease component
K6I41_10740	COG0012	GTP binding
K6I41_10765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
K6I41_10800	COG1917	Cupin 2, conserved barrel domain protein
K6I41_10800	COG2207	Transcriptional regulator
K6I41_10805	COG0386	Belongs to the glutathione peroxidase family
K6I41_10815	COG0436	Aminotransferase
K6I41_10820	COG1301	dicarboxylic acid transport
K6I41_10855	COG3634	alkyl hydroperoxide reductase activity
K6I41_10870	COG0583	DNA-binding transcription factor activity
K6I41_10875	COG0431	NADPH-dependent FMN reductase
K6I41_10880	COG0798	PFAM Bile acid sodium symporter
K6I41_10890	COG0640	Transcriptional regulator
K6I41_10905	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K6I41_10915	COG0583	DNA-binding transcription factor activity
K6I41_10925	COG1953	Uracil, thiamine, allantoin
K6I41_10935	COG2175	clavaminate synthase activity
K6I41_10940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6I41_10945	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
K6I41_10950	COG4521	taurine ABC transporter
K6I41_10960	COG0477	Major facilitator Superfamily
K6I41_10980	COG1271	oxidase subunit
K6I41_10985	COG1294	oxidase, subunit
K6I41_10995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6I41_11015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K6I41_11035	COG3052	prosthetic group binding
K6I41_11040	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
K6I41_11050	COG2814	Major facilitator Superfamily
K6I41_11070	COG1346	cytolysis
K6I41_11080	COG0583	DNA-binding transcription factor activity
K6I41_11085	COG0625	glutathione transferase activity
K6I41_11090	COG0625	glutathione transferase activity
K6I41_11110	COG0583	DNA-binding transcription factor activity
K6I41_11125	COG1045	serine acetyltransferase
K6I41_11130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6I41_11135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6I41_11140	COG1280	lysine exporter protein (LysE YggA)
K6I41_11155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6I41_11160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6I41_11170	COG0765	amino acid transport
K6I41_11175	COG0765	amino acid transport
K6I41_11215	COG0784	Response regulator, receiver
K6I41_11215	COG2205	protein histidine kinase activity
K6I41_11235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6I41_11255	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_11295	COG0583	DNA-binding transcription factor activity
K6I41_11305	COG2814	Major facilitator Superfamily
K6I41_11320	COG0318	PFAM AMP-dependent synthetase and ligase
K6I41_11325	COG1309	transcriptional regulator
K6I41_11330	COG1960	acyl-CoA dehydrogenase activity
K6I41_11335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6I41_11340	COG1024	Enoyl-CoA hydratase
K6I41_11345	COG4770	biotin carboxylase activity
K6I41_11355	COG0583	DNA-binding transcription factor activity
K6I41_11370	COG1960	acyl-CoA dehydrogenase activity
K6I41_11380	COG2814	Major facilitator Superfamily
K6I41_11390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K6I41_11395	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K6I41_11400	COG2814	Major facilitator Superfamily
K6I41_11405	COG1960	acyl-CoA dehydrogenase activity
K6I41_11410	COG1024	Enoyl-CoA hydratase
K6I41_11415	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_11420	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6I41_11425	COG0183	Belongs to the thiolase family
K6I41_11445	COG2192	nodulation
K6I41_11460	COG1024	Enoyl-CoA hydratase
K6I41_11470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K6I41_11475	COG1960	acyl-CoA dehydrogenase activity
K6I41_11480	COG2814	Major facilitator Superfamily
K6I41_11485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6I41_11490	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K6I41_11505	COG3842	ATPase activity
K6I41_11510	COG1840	ABC-type Fe3 transport system, periplasmic component
K6I41_11520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6I41_11525	COG1414	Transcriptional regulator
K6I41_11535	COG0583	DNA-binding transcription factor activity
K6I41_11550	COG0406	alpha-ribazole phosphatase activity
K6I41_11560	COG1760	l-serine dehydratase
K6I41_11565	COG0531	amino acid
K6I41_11570	COG1012	belongs to the aldehyde dehydrogenase family
K6I41_11595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6I41_11615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6I41_11630	COG0789	Transcriptional regulator
K6I41_11640	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6I41_11645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6I41_11660	COG2807	transmembrane transport
K6I41_11665	COG0590	tRNA wobble adenosine to inosine editing
K6I41_11670	COG0666	response to abiotic stimulus
K6I41_11715	COG2885	chlorophyll binding
K6I41_11810	COG0477	Major facilitator Superfamily
K6I41_11825	COG1116	anion transmembrane transporter activity
K6I41_11830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6I41_11840	COG0864	Transcriptional regulator
K6I41_11850	COG1733	regulation of RNA biosynthetic process
K6I41_11855	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6I41_11860	COG0439	Biotin carboxylase
K6I41_11875	COG1063	alcohol dehydrogenase
K6I41_11880	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6I41_11940	COG0038	chloride channel
K6I41_11945	COG4770	biotin carboxylase activity
K6I41_11965	COG1914	H( )-stimulated, divalent metal cation uptake system
K6I41_11975	COG0300	oxidoreductase activity
K6I41_11990	COG0300	oxidoreductase activity
K6I41_11995	COG2072	flavoprotein involved in K transport
K6I41_12040	COG1309	transcriptional regulator
K6I41_12045	COG1073	alpha beta
K6I41_12050	COG1073	alpha beta
K6I41_12060	COG1309	transcriptional regulator
K6I41_12075	COG0657	acetylesterase activity
K6I41_12090	COG1595	DNA-templated transcription, initiation
K6I41_12095	COG3712	iron ion homeostasis
K6I41_12125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6I41_12130	COG4774	siderophore transport
K6I41_12155	COG4521	taurine ABC transporter
K6I41_12160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6I41_12165	COG1116	anion transmembrane transporter activity
K6I41_12170	COG2515	1-aminocyclopropane-1-carboxylate deaminase
K6I41_12180	COG3038	cytochrome b561
K6I41_12185	COG0753	catalase activity
K6I41_12200	COG1278	Cold shock
K6I41_12235	COG1522	sequence-specific DNA binding
K6I41_12240	COG0531	amino acid
K6I41_12245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6I41_12260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6I41_12350	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_12360	COG2050	protein possibly involved in aromatic compounds catabolism
K6I41_12370	COG3327	negative regulation of DNA-templated transcription, initiation
K6I41_12375	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K6I41_12380	COG0183	Belongs to the thiolase family
K6I41_12385	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6I41_12390	COG1024	Enoyl-CoA hydratase
K6I41_12395	COG1024	Enoyl-CoA hydratase
K6I41_12400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6I41_12405	COG2151	metal-sulfur cluster biosynthetic enzyme
K6I41_12410	COG3396	Phenylacetate-CoA oxygenase
K6I41_12415	COG3460	Phenylacetate-CoA oxygenase
K6I41_12420	COG3396	Phenylacetate-CoA oxygenase
K6I41_12425	COG2030	dehydratase
K6I41_12425	COG1012	belongs to the aldehyde dehydrogenase family
K6I41_12455	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K6I41_12465	COG4122	O-methyltransferase activity
K6I41_12500	COG1137	ATPase activity
K6I41_12505	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K6I41_12515	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K6I41_12540	COG1476	TRANSCRIPTIONal
K6I41_12585	COG1714	RDD family
K6I41_12615	COG2814	Major facilitator Superfamily
K6I41_12630	COG0668	transmembrane transport
K6I41_12695	COG2226	methyltransferase
K6I41_12720	COG1278	Cold shock
K6I41_12725	COG1560	Kdo2-lipid A biosynthetic process
K6I41_12730	COG1280	lysine exporter protein (LysE YggA)
K6I41_12765	COG1570	exodeoxyribonuclease VII activity
K6I41_12795	COG3791	Glutathione-dependent formaldehyde-activating
K6I41_12850	COG2871	sodium ion transport
K6I41_12860	COG0583	DNA-binding transcription factor activity
K6I41_12870	COG4638	Rieske (2fe-2S)
K6I41_12875	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
K6I41_12880	COG0543	2 iron, 2 sulfur cluster binding
K6I41_12880	COG0633	Ferredoxin
K6I41_12885	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_12890	COG3135	benzoate transporter
K6I41_12895	COG2814	Major facilitator Superfamily
K6I41_12910	COG1643	Atp-dependent helicase
K6I41_12925	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6I41_12945	COG3634	alkyl hydroperoxide reductase activity
K6I41_12965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K6I41_12970	COG0625	glutathione transferase activity
K6I41_12980	COG2885	chlorophyll binding
K6I41_13015	COG0542	response to heat
K6I41_13030	COG1765	OsmC-like protein
K6I41_13040	COG0667	Aldo Keto reductase
K6I41_13055	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6I41_13070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6I41_13080	COG0527	aspartate kinase activity
K6I41_13090	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K6I41_13100	COG3038	cytochrome b561
K6I41_13105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K6I41_13110	COG2252	PERMEase
K6I41_13120	COG1741	Belongs to the pirin family
K6I41_13125	COG1309	transcriptional regulator
K6I41_13140	COG2072	flavoprotein involved in K transport
K6I41_13145	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K6I41_13150	COG0583	DNA-binding transcription factor activity
K6I41_13165	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K6I41_13195	COG1944	ATP diphosphatase activity
K6I41_13215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K6I41_13230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6I41_13245	COG2814	Major facilitator Superfamily
K6I41_13250	COG1024	Enoyl-CoA hydratase
K6I41_13255	COG1012	belongs to the aldehyde dehydrogenase family
K6I41_13265	COG1960	acyl-CoA dehydrogenase activity
K6I41_13290	COG0697	spore germination
K6I41_13310	COG1113	amino acid transport
K6I41_13330	COG1012	belongs to the aldehyde dehydrogenase family
K6I41_13350	COG0531	amino acid
K6I41_13360	COG1113	amino acid transport
K6I41_13370	COG1309	transcriptional regulator
K6I41_13375	COG4269	membrane
K6I41_13390	COG2207	Transcriptional regulator
K6I41_13425	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6I41_13425	COG1902	pentaerythritol trinitrate reductase activity
K6I41_13435	COG5001	Diguanylate cyclase
K6I41_13435	COG4251	negative regulation of phosphorylation
K6I41_13435	COG3706	GGDEF domain
K6I41_13435	COG2203	Gaf domain
K6I41_13445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K6I41_13475	COG4172	Belongs to the ABC transporter superfamily
K6I41_13480	COG4239	(ABC) transporter, permease
K6I41_13485	COG4174	ABC transporter (Permease)
K6I41_13490	COG4166	transmembrane transport
K6I41_13495	COG0741	lytic transglycosylase activity
K6I41_13495	COG0741	lytic transglycosylase activity
K6I41_13495	COG1388	LysM domain
K6I41_13495	COG1388	LysM domain
K6I41_13540	COG0583	DNA-binding transcription factor activity
K6I41_13545	COG1279	arginine transmembrane transporter activity
K6I41_13555	COG0789	Transcriptional regulator
K6I41_13565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6I41_13570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6I41_13575	COG0006	proline dipeptidase activity
K6I41_13690	COG0739	heme binding
K6I41_13715	COG0758	DNA mediated transformation
K6I41_13910	COG2887	Belongs to the helicase family. UvrD subfamily
K6I41_13950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6I41_13965	COG3384	dioxygenase
K6I41_13975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6I41_13980	COG2878	Part of a membrane complex involved in electron transport
K6I41_13985	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6I41_14010	COG0768	penicillin binding
K6I41_14015	COG0742	ribosomal rna small subunit methyltransferase
K6I41_14030	COG0830	nickel cation binding
K6I41_14040	COG0804	urea catabolic process
K6I41_14065	COG3015	lipoprotein NlpE involved in copper resistance
K6I41_14080	COG1253	flavin adenine dinucleotide binding
K6I41_14085	COG2851	Citrate transporter
K6I41_14135	COG1773	rubredoxin
K6I41_14140	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6I41_14150	COG0583	DNA-binding transcription factor activity
K6I41_14180	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K6I41_14185	COG4181	ATPase activity
K6I41_14230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K6I41_14250	COG0306	phosphate transporter
K6I41_14265	COG3958	Transketolase
K6I41_14270	COG3959	Transketolase, thiamine diphosphate binding domain
K6I41_14275	COG2271	Major facilitator Superfamily
K6I41_14280	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_14285	COG0583	DNA-binding transcription factor activity
K6I41_14300	COG2223	nitrite transmembrane transporter activity
K6I41_14310	COG2066	Belongs to the glutaminase family
K6I41_14315	COG0242	peptide deformylase activity
K6I41_14320	COG0477	Major facilitator Superfamily
K6I41_14330	COG0028	Belongs to the TPP enzyme family
K6I41_14345	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_14350	COG2267	carboxylic ester hydrolase activity
K6I41_14360	COG2271	Major facilitator Superfamily
K6I41_14375	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_14395	COG1414	Transcriptional regulator
K6I41_14415	COG1024	Enoyl-CoA hydratase
K6I41_14425	COG1309	transcriptional regulator
K6I41_14435	COG1215	transferase activity, transferring glycosyl groups
K6I41_14440	COG0726	polysaccharide deacetylase
K6I41_14440	COG1649	PFAM Uncharacterised BCR, COG1649
K6I41_14450	COG4681	YaeQ
K6I41_14460	COG0523	cobalamin synthesis protein
K6I41_14470	COG1607	acyl-coa hydrolase
K6I41_14480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6I41_14485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6I41_14490	COG1309	transcriptional regulator
K6I41_14515	COG2040	homocysteine
K6I41_14520	COG0531	amino acid
K6I41_14575	COG1595	DNA-templated transcription, initiation
K6I41_14585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6I41_14590	COG0477	Major facilitator Superfamily
K6I41_14650	COG0405	Gamma-glutamyltransferase
K6I41_14655	COG2814	Major facilitator Superfamily
K6I41_14660	COG1566	PFAM secretion protein HlyD family protein
K6I41_14665	COG2050	protein possibly involved in aromatic compounds catabolism
K6I41_14680	COG1090	epimerase
K6I41_14700	COG0420	3'-5' exonuclease activity
K6I41_14710	COG1968	undecaprenyl-diphosphatase activity
K6I41_14730	COG0735	belongs to the Fur family
K6I41_14735	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6I41_14740	COG2914	Belongs to the UPF0125 (RnfH) family
K6I41_14755	COG0121	glutamine amidotransferase
K6I41_14770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6I41_14780	COG0210	DNA helicase
K6I41_14785	COG2885	chlorophyll binding
K6I41_14790	COG0204	Acyl-transferase
K6I41_14820	COG1280	lysine exporter protein (LysE YggA)
K6I41_14825	COG1674	ftsk spoiiie
K6I41_14830	COG0492	ferredoxin-NADP+ reductase activity
K6I41_14835	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K6I41_14845	COG0456	acetyltransferase
K6I41_14865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6I41_14870	COG0049	tRNA binding
K6I41_14875	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K6I41_14890	COG1981	membrane
K6I41_14900	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K6I41_14900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6I41_14920	COG1012	belongs to the aldehyde dehydrogenase family
K6I41_14925	COG4638	Rieske (2fe-2S)
K6I41_14930	COG0657	acetylesterase activity
K6I41_14940	COG0473	3-isopropylmalate dehydrogenase activity
K6I41_14945	COG0583	DNA-binding transcription factor activity
K6I41_14965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6I41_15005	COG0358	DNA primase activity
K6I41_15020	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K6I41_15050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6I41_15080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6I41_15090	COG0351	phosphomethylpyrimidine kinase
K6I41_15090	COG0352	thiamine-phosphate diphosphorylase activity
K6I41_15090	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K6I41_15095	COG1652	LysM domain
K6I41_15120	COG1399	metal-binding, possibly nucleic acid-binding protein
K6I41_15125	COG3101	peptidyl-lysine hydroxylation
K6I41_15130	COG0009	L-threonylcarbamoyladenylate synthase
K6I41_15135	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K6I41_15140	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K6I41_15155	COG4106	trans-aconitate 2-methyltransferase activity
K6I41_15170	COG2226	methyltransferase
K6I41_15170	COG0596	Alpha beta hydrolase
K6I41_15170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K6I41_15180	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
K6I41_15185	COG2223	nitrite transmembrane transporter activity
K6I41_15205	COG1196	nuclear chromosome segregation
K6I41_15215	COG0730	response to heat
K6I41_15220	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K6I41_15220	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K6I41_15230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6I41_15285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6I41_15290	COG0489	protein tyrosine kinase activity
K6I41_15300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6I41_15300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6I41_15335	COG2515	1-aminocyclopropane-1-carboxylate deaminase
K6I41_15340	COG2081	HI0933 family
K6I41_15350	COG0668	transmembrane transport
K6I41_15370	COG0583	DNA-binding transcription factor activity
K6I41_15390	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6I41_15395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6I41_15425	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K6I41_15450	COG2199	diguanylate cyclase activity
K6I41_15465	COG0745	RESPONSE REGULATOR receiver
K6I41_15485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6I41_15515	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K6I41_15520	COG0583	DNA-binding transcription factor activity
K6I41_15550	COG1309	transcriptional regulator
K6I41_15555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K6I41_15580	COG0583	DNA-binding transcription factor activity
K6I41_15595	COG0583	DNA-binding transcription factor activity
K6I41_15600	COG1053	succinate dehydrogenase
K6I41_15615	COG1309	transcriptional regulator
K6I41_15625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K6I41_15630	COG2814	Major facilitator Superfamily
K6I41_15635	COG1960	acyl-CoA dehydrogenase activity
K6I41_15640	COG0583	DNA-binding transcription factor activity
K6I41_15645	COG1063	alcohol dehydrogenase
K6I41_15675	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K6I41_15680	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K6I41_15685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6I41_15705	COG2132	Multicopper oxidase
K6I41_15715	COG0561	phosphatase activity
K6I41_15720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6I41_15745	COG1214	PFAM Peptidase M22, glycoprotease
K6I41_15805	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6I41_15810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K6I41_15815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6I41_15875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6I41_15885	COG1846	Transcriptional regulator
K6I41_15890	COG1764	response to oxidative stress
K6I41_15930	COG0037	tRNA processing
K6I41_15940	COG0248	Ppx GppA phosphatase
K6I41_15970	COG0072	phenylalanine-tRNA ligase activity
K6I41_16000	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6I41_16010	COG1238	metal cluster binding
K6I41_16015	COG0625	glutathione transferase activity
K6I41_16020	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K6I41_16030	COG0318	PFAM AMP-dependent synthetase and ligase
K6I41_16035	COG3028	Belongs to the UPF0307 family
K6I41_16040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6I41_16060	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6I41_16065	COG0617	tRNA 3'-terminal CCA addition
K6I41_16070	COG1555	photosystem II stabilization
K6I41_16075	COG3956	TIGRFAM MazG family protein
K6I41_16080	COG4221	oxidoreductase activity
K6I41_16085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6I41_16100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6I41_16105	COG0784	Response regulator, receiver
K6I41_16105	COG2205	protein histidine kinase activity
K6I41_16105	COG5002	protein histidine kinase activity
K6I41_16110	COG1024	Enoyl-CoA hydratase
K6I41_16115	COG2084	Dehydrogenase
K6I41_16120	COG3622	Belongs to the hyi family
K6I41_16150	COG0697	spore germination
K6I41_16160	COG2814	Major facilitator Superfamily
K6I41_16165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6I41_16180	COG0583	DNA-binding transcription factor activity
K6I41_16190	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6I41_16200	COG0084	hydrolase, TatD family'
K6I41_16215	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K6I41_16240	COG0440	acetolactate synthase activity
K6I41_16245	COG0028	Belongs to the TPP enzyme family
K6I41_16270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6I41_16275	COG0577	efflux transmembrane transporter activity
K6I41_16275	COG1136	(ABC) transporter
K6I41_16295	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K6I41_16300	COG1162	GTPase activity
K6I41_16310	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6I41_16330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6I41_16335	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_16385	COG1216	Glycosyl transferase, family 2
K6I41_16390	COG0318	PFAM AMP-dependent synthetase and ligase
K6I41_16400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6I41_16425	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6I41_16445	COG1426	Protein conserved in bacteria
K6I41_16465	COG2975	iron-sulfur cluster assembly
K6I41_16480	COG0793	Belongs to the peptidase S41A family
K6I41_16495	COG2267	carboxylic ester hydrolase activity
K6I41_16505	COG3265	gluconokinase activity
K6I41_16515	COG0800	Aldolase
K6I41_16530	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6I41_16535	COG0280	phosphate acetyltransferase
K6I41_16535	COG0857	belongs to the CobB CobQ family
K6I41_16540	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K6I41_16540	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
K6I41_16560	COG0740	serine-type endopeptidase activity
K6I41_16570	COG4774	siderophore transport
K6I41_16580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6I41_16590	COG2813	Specifically methylates the guanine in position
K6I41_16590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K6I41_16690	COG0788	formyltetrahydrofolate deformylase activity
K6I41_16715	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6I41_16715	COG4651	solute:proton antiporter activity
K6I41_16735	COG0724	RNA recognition motif
K6I41_16740	COG0210	DNA helicase
K6I41_16765	COG1733	regulation of RNA biosynthetic process
K6I41_16770	COG0604	alcohol dehydrogenase
K6I41_16775	COG2900	Belongs to the SlyX family
K6I41_16780	COG0488	(ABC) transporter
K6I41_16790	COG1560	Kdo2-lipid A biosynthetic process
K6I41_16800	COG1301	dicarboxylic acid transport
K6I41_16855	COG0473	3-isopropylmalate dehydrogenase activity
K6I41_16880	COG0583	DNA-binding transcription factor activity
K6I41_16920	COG0583	DNA-binding transcription factor activity
K6I41_16930	COG0625	glutathione transferase activity
K6I41_16935	COG2378	regulation of single-species biofilm formation
K6I41_16950	COG1530	ribonuclease E activity
K6I41_16955	COG0318	PFAM AMP-dependent synthetase and ligase
K6I41_16970	COG0583	DNA-binding transcription factor activity
K6I41_16975	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_16980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6I41_16990	COG0534	Mate efflux family protein
K6I41_17005	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K6I41_17030	COG0493	'glutamate synthase
K6I41_17040	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K6I41_17045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6I41_17060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K6I41_17070	COG0644	oxidoreductase
K6I41_17070	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
K6I41_17085	COG4535	Mg2 and Co2 transporter CorC
K6I41_17095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6I41_17120	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6I41_17130	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K6I41_17140	COG0484	heat shock protein binding
K6I41_17145	COG0789	Transcriptional regulator
K6I41_17150	COG0598	Magnesium transport protein CorA
K6I41_17155	COG1185	polyribonucleotide nucleotidyltransferase activity
K6I41_17165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K6I41_17170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6I41_17175	COG1074	ATP-dependent DNA helicase activity
K6I41_17180	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K6I41_17200	COG2226	methyltransferase
K6I41_17210	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K6I41_17230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K6I41_17245	COG2111	Na H antiporter
K6I41_17245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6I41_17250	COG1006	Multisubunit Na H antiporter MnhC subunit
K6I41_17255	COG0651	ATP synthesis coupled electron transport
K6I41_17260	COG1863	multisubunit Na H antiporter MnhE subunit
K6I41_17265	COG2212	antiporter activity
K6I41_17270	COG1320	monovalent cation:proton antiporter activity
K6I41_17275	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6I41_17285	COG0195	Participates in both transcription termination and antitermination
K6I41_17335	COG0237	dephospho-CoA kinase activity
K6I41_17345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6I41_17360	COG0497	DNA recombination
K6I41_17370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6I41_17405	COG2169	Transcriptional regulator
K6I41_17405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6I41_17410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K6I41_17480	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K6I41_17495	COG0326	Molecular chaperone. Has ATPase activity
K6I41_17510	COG2056	Na+-H+ antiporter family
K6I41_17545	COG0222	ribosome binding
K6I41_17550	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K6I41_17610	COG0546	phosphoglycolate phosphatase activity
K6I41_17615	COG1716	ATPase activity
K6I41_17660	COG0181	hydroxymethylbilane synthase activity
K6I41_17670	COG3275	phosphorelay sensor kinase activity
K6I41_17690	COG1538	Outer membrane efflux protein
K6I41_17700	COG0697	spore germination
K6I41_17720	COG0494	nUDIX hydrolase
K6I41_17730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K6I41_17735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6I41_17740	COG0772	Belongs to the SEDS family
K6I41_17765	COG4974	Belongs to the 'phage' integrase family
K6I41_17770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6I41_17780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K6I41_17790	COG2197	response regulator
K6I41_17805	COG0793	Belongs to the peptidase S41A family
K6I41_17810	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K6I41_17815	COG0795	lipopolysaccharide-transporting ATPase activity
K6I41_17855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6I41_17855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6I41_17865	COG0004	ammonium transporteR
K6I41_17870	COG0347	Belongs to the P(II) protein family
K6I41_17880	COG0606	chelatase, subunit chli
K6I41_17885	COG0431	NADPH-dependent FMN reductase
K6I41_17890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6I41_17895	COG0235	Class ii aldolase
K6I41_17900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6I41_17915	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K6I41_17930	COG0318	PFAM AMP-dependent synthetase and ligase
K6I41_17940	COG0477	Major facilitator Superfamily
K6I41_17945	COG2860	membrane
K6I41_17955	COG1253	flavin adenine dinucleotide binding
K6I41_17965	COG2814	Major facilitator Superfamily
K6I41_17975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K6I41_18015	COG0655	NAD(P)H dehydrogenase (quinone) activity
K6I41_18030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6I41_18065	COG1309	transcriptional regulator
K6I41_18100	COG0758	DNA mediated transformation
K6I41_18110	COG0697	spore germination
K6I41_18115	COG1309	transcriptional regulator
K6I41_18130	COG0386	Belongs to the glutathione peroxidase family
K6I41_18140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K6I41_18145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K6I41_18195	COG1121	(ABC) transporter
K6I41_18200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6I41_18205	COG1280	lysine exporter protein (LysE YggA)
K6I41_18210	COG2837	iron assimilation
K6I41_18215	COG0281	malic enzyme
K6I41_18260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K6I41_18260	COG0519	Catalyzes the synthesis of GMP from XMP
K6I41_18265	COG4399	Belongs to the UPF0754 family
K6I41_18270	COG2259	Doxx family
K6I41_18275	COG0586	Pfam SNARE associated Golgi protein
K6I41_18290	COG1192	Involved in chromosome partitioning
K6I41_18300	COG0271	Belongs to the BolA IbaG family
K6I41_18345	COG1960	acyl-CoA dehydrogenase activity
K6I41_18355	COG2197	response regulator
K6I41_18365	COG3916	Acyl-homoserine-lactone synthase
K6I41_18370	COG0477	Major facilitator Superfamily
K6I41_18375	COG1024	Enoyl-CoA hydratase
K6I41_18380	COG1024	Enoyl-CoA hydratase
K6I41_18385	COG1960	acyl-CoA dehydrogenase activity
K6I41_18390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6I41_18410	COG1113	amino acid transport
K6I41_18415	COG1113	amino acid transport
K6I41_18420	COG0251	oxidation-reduction process
K6I41_18460	COG0564	pseudouridine synthase activity
K6I41_18475	COG1309	transcriptional regulator
K6I41_18485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K6I41_18525	COG1051	belongs to the nudix hydrolase family
K6I41_18545	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K6I41_18560	COG1802	Transcriptional regulator
K6I41_18565	COG1448	Aminotransferase
K6I41_18570	COG0277	FAD linked oxidase domain protein
K6I41_18580	COG2186	Transcriptional regulator
K6I41_18590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6I41_18610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K6I41_18620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6I41_18630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6I41_18635	COG0438	transferase activity, transferring glycosyl groups
K6I41_18660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K6I41_18690	COG0728	peptidoglycan biosynthetic process
K6I41_18695	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6I41_18725	COG1017	nitric oxide dioxygenase activity
K6I41_18725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6I41_18750	COG0546	phosphoglycolate phosphatase activity
K6I41_18755	COG1028	Short-chain dehydrogenase reductase Sdr
K6I41_18770	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K6I41_18770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6I41_18775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6I41_18780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6I41_18785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6I41_18790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6I41_18795	COG1116	anion transmembrane transporter activity
K6I41_18800	COG1309	transcriptional regulator
K6I41_18805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6I41_18815	COG0196	riboflavin kinase activity
K6I41_18820	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K6I41_18830	COG1047	Peptidyl-prolyl cis-trans
K6I41_18875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6I41_18880	COG0657	acetylesterase activity
K6I41_18930	COG2951	lytic endotransglycosylase activity
K6I41_18935	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K6I41_18950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6I41_18960	COG0671	phosphoesterase, PA-phosphatase related
K6I41_18965	COG0861	Integral membrane protein TerC family
K6I41_18975	COG0402	S-adenosylhomocysteine deaminase activity
K6I41_18990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6I41_18995	COG1230	cation diffusion facilitator family transporter
K6I41_19010	COG0706	membrane insertase activity