locus-tag	class	description
IOD65_00010	COG0386	Belongs to the glutathione peroxidase family
IOD65_00025	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IOD65_00035	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IOD65_00075	COG1121	(ABC) transporter
IOD65_00080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD65_00085	COG1280	lysine exporter protein (LysE YggA)
IOD65_00090	COG2837	iron assimilation
IOD65_00095	COG0281	malic enzyme
IOD65_00135	COG0519	Catalyzes the synthesis of GMP from XMP
IOD65_00135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IOD65_00140	COG4399	Belongs to the UPF0754 family
IOD65_00145	COG2259	Doxx family
IOD65_00150	COG0586	Pfam SNARE associated Golgi protein
IOD65_00165	COG1192	Involved in chromosome partitioning
IOD65_00175	COG0271	Belongs to the BolA IbaG family
IOD65_00215	COG3321	synthase
IOD65_00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOD65_00215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IOD65_00215	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IOD65_00220	COG1960	acyl-CoA dehydrogenase activity
IOD65_00225	COG0318	PFAM AMP-dependent synthetase and ligase
IOD65_00230	COG2197	response regulator
IOD65_00245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD65_00255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD65_00260	COG1113	amino acid transport
IOD65_00265	COG0697	spore germination
IOD65_00270	COG0477	Major facilitator Superfamily
IOD65_00275	COG1024	Enoyl-CoA hydratase
IOD65_00280	COG1024	Enoyl-CoA hydratase
IOD65_00285	COG1960	acyl-CoA dehydrogenase activity
IOD65_00290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOD65_00310	COG1113	amino acid transport
IOD65_00315	COG1113	amino acid transport
IOD65_00320	COG0251	oxidation-reduction process
IOD65_00360	COG0564	pseudouridine synthase activity
IOD65_00390	COG2826	transposase and inactivated derivatives, IS30 family
IOD65_00425	COG1051	belongs to the nudix hydrolase family
IOD65_00450	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IOD65_00465	COG1802	Transcriptional regulator
IOD65_00475	COG1448	Aminotransferase
IOD65_00480	COG0277	FAD linked oxidase domain protein
IOD65_00490	COG2186	Transcriptional regulator
IOD65_00500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOD65_00515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IOD65_00520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IOD65_00555	COG1091	dTDP-4-dehydrorhamnose reductase activity
IOD65_00565	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IOD65_00585	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IOD65_00615	COG0728	peptidoglycan biosynthetic process
IOD65_00620	COG3023	N-Acetylmuramoyl-L-alanine amidase
IOD65_00675	COG0546	phosphoglycolate phosphatase activity
IOD65_00680	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_00695	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IOD65_00695	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IOD65_00700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOD65_00705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOD65_00710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD65_00715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD65_00720	COG1116	anion transmembrane transporter activity
IOD65_00725	COG1309	transcriptional regulator
IOD65_00730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IOD65_00740	COG0196	riboflavin kinase activity
IOD65_00745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IOD65_00755	COG1047	Peptidyl-prolyl cis-trans
IOD65_00795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IOD65_00800	COG0657	acetylesterase activity
IOD65_00840	COG2826	transposase and inactivated derivatives, IS30 family
IOD65_00860	COG2951	lytic endotransglycosylase activity
IOD65_00865	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IOD65_00880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IOD65_00890	COG0671	phosphoesterase, PA-phosphatase related
IOD65_00895	COG0861	Integral membrane protein TerC family
IOD65_00905	COG0754	glutathionylspermidine amidase activity
IOD65_00915	COG0402	S-adenosylhomocysteine deaminase activity
IOD65_00930	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOD65_00935	COG1230	cation diffusion facilitator family transporter
IOD65_00950	COG0706	membrane insertase activity
IOD65_00975	COG0592	DNA-directed DNA polymerase activity
IOD65_00985	COG0187	DNA topoisomerase II activity
IOD65_01000	COG0488	(ABC) transporter
IOD65_01025	COG0596	Alpha beta hydrolase
IOD65_01030	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IOD65_01035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IOD65_01065	COG0625	glutathione transferase activity
IOD65_01075	COG0733	neurotransmitter:sodium symporter activity
IOD65_01115	COG2233	PERMEase
IOD65_01130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD65_01165	COG2814	Major facilitator Superfamily
IOD65_01170	COG0656	L-ascorbic acid biosynthetic process
IOD65_01175	COG0583	DNA-binding transcription factor activity
IOD65_01190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD65_01195	COG1064	alcohol dehydrogenase
IOD65_01200	COG2818	Glycosylase
IOD65_01215	COG1194	a g-specific adenine glycosylase
IOD65_01230	COG5487	UPF0391 membrane protein
IOD65_01235	COG2983	Belongs to the UPF0260 family
IOD65_01240	COG2133	pyrroloquinoline quinone binding
IOD65_01245	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IOD65_01250	COG2116	formate transmembrane transporter activity
IOD65_01270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD65_01275	COG1335	isochorismatase
IOD65_01280	COG0385	Bile acid
IOD65_01285	COG0534	Mate efflux family protein
IOD65_01290	COG1683	Conserved Protein
IOD65_01305	COG0346	lactoylglutathione lyase activity
IOD65_01310	COG0625	glutathione transferase activity
IOD65_01320	COG1113	amino acid transport
IOD65_01330	COG0523	cobalamin synthesis protein
IOD65_01340	COG2188	Transcriptional regulator
IOD65_01370	COG0010	Belongs to the arginase family
IOD65_01435	COG0546	phosphoglycolate phosphatase activity
IOD65_01440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IOD65_01450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOD65_01460	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IOD65_01465	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IOD65_01565	COG0534	Mate efflux family protein
IOD65_01570	COG0436	Aminotransferase
IOD65_01575	COG2733	membrane
IOD65_01590	COG2918	glutathione biosynthetic process
IOD65_01605	COG1705	Flagellar rod assembly protein muramidase FlgJ
IOD65_01605	COG1388	LysM domain
IOD65_01625	COG3150	esterase
IOD65_01635	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IOD65_01645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD65_01655	COG2233	PERMEase
IOD65_01660	COG2351	hydroxyisourate hydrolase activity
IOD65_01695	COG3706	GGDEF domain
IOD65_01710	COG1393	Belongs to the ArsC family
IOD65_01715	COG0708	Exodeoxyribonuclease III
IOD65_01740	COG0189	ligase activity
IOD65_01760	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IOD65_01770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IOD65_01785	COG4942	peptidase
IOD65_01795	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD65_01805	COG2119	membrane
IOD65_01810	COG4774	siderophore transport
IOD65_01815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOD65_01815	COG0426	domain, Protein
IOD65_01835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IOD65_01855	COG1902	pentaerythritol trinitrate reductase activity
IOD65_01860	COG1519	Transferase
IOD65_01865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IOD65_01870	COG0668	transmembrane transport
IOD65_01880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOD65_01885	COG1335	isochorismatase
IOD65_01890	COG1522	sequence-specific DNA binding
IOD65_01915	COG0784	Response regulator, receiver
IOD65_01915	COG2198	Histidine kinase
IOD65_01915	COG2205	protein histidine kinase activity
IOD65_01920	COG3162	membrane
IOD65_01925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD65_01935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOD65_01955	COG1309	transcriptional regulator
IOD65_01975	COG0300	oxidoreductase activity
IOD65_01980	COG0789	Transcriptional regulator
IOD65_01985	COG0351	phosphomethylpyrimidine kinase
IOD65_01985	COG0352	thiamine-phosphate diphosphorylase activity
IOD65_01985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IOD65_01995	COG2814	Major facilitator Superfamily
IOD65_02010	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IOD65_02020	COG1113	amino acid transport
IOD65_02030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOD65_02035	COG1012	belongs to the aldehyde dehydrogenase family
IOD65_02045	COG1335	isochorismatase
IOD65_02075	COG2814	Major facilitator Superfamily
IOD65_02080	COG0583	DNA-binding transcription factor activity
IOD65_02100	COG0667	Aldo Keto reductase
IOD65_02135	COG1733	regulation of RNA biosynthetic process
IOD65_02140	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOD65_02220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IOD65_02235	COG2329	Antibiotic biosynthesis monooxygenase
IOD65_02240	COG0697	spore germination
IOD65_02255	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IOD65_02265	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IOD65_02295	COG0427	acetyl-CoA hydrolase
IOD65_02320	COG0659	secondary active sulfate transmembrane transporter activity
IOD65_02325	COG4221	oxidoreductase activity
IOD65_02330	COG2873	o-acetylhomoserine
IOD65_02335	COG0488	(ABC) transporter
IOD65_02415	COG0833	amino acid
IOD65_02460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IOD65_02465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IOD65_02480	COG2226	methyltransferase
IOD65_02530	COG0067	glutamate synthase
IOD65_02530	COG0070	glutamate synthase
IOD65_02530	COG0069	glutamate synthase activity
IOD65_02535	COG0493	'glutamate synthase
IOD65_02545	COG1704	LemA family
IOD65_02550	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IOD65_02570	COG3307	-O-antigen
IOD65_02595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOD65_02610	COG0194	GDP metabolic process
IOD65_02660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IOD65_02670	COG0335	large ribosomal subunit rRNA binding
IOD65_02680	COG5380	lipid catabolic process
IOD65_02685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IOD65_02700	COG5006	permease, DMT superfamily
IOD65_02710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IOD65_02715	COG0277	FAD linked oxidase domain protein
IOD65_02725	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IOD65_02730	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOD65_02745	COG1289	transmembrane transporter activity
IOD65_02755	COG0628	permease
IOD65_02760	COG1192	Involved in chromosome partitioning
IOD65_02790	COG0833	amino acid
IOD65_02795	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IOD65_02800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOD65_02810	COG1012	belongs to the aldehyde dehydrogenase family
IOD65_02850	COG0583	DNA-binding transcription factor activity
IOD65_02875	COG0752	glycyl-tRNA synthetase alpha subunit
IOD65_02900	COG0517	IMP dehydrogenase activity
IOD65_02905	COG1983	PspC domain protein
IOD65_02915	COG1960	acyl-CoA dehydrogenase activity
IOD65_02930	COG0408	coproporphyrinogen oxidase activity
IOD65_02950	COG0513	Belongs to the DEAD box helicase family
IOD65_02960	COG1127	ABC transporter
IOD65_02965	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IOD65_02975	COG2854	intermembrane phospholipid transfer
IOD65_02985	COG0598	Magnesium transport protein CorA
IOD65_02995	COG0494	nUDIX hydrolase
IOD65_03000	COG1040	competence protein
IOD65_03005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IOD65_03025	COG1946	Acyl-CoA thioesterase
IOD65_03030	COG1301	dicarboxylic acid transport
IOD65_03045	COG1959	2 iron, 2 sulfur cluster binding
IOD65_03050	COG1017	nitric oxide dioxygenase activity
IOD65_03050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD65_03060	COG0433	COG0433 Predicted ATPase
IOD65_03065	COG0626	cystathionine gamma-synthase activity
IOD65_03080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IOD65_03085	COG0088	Forms part of the polypeptide exit tunnel
IOD65_03220	COG1960	acyl-CoA dehydrogenase activity
IOD65_03225	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IOD65_03255	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IOD65_03260	COG0339	signal peptide processing
IOD65_03265	COG0557	exoribonuclease II activity
IOD65_03315	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOD65_03320	COG1295	ribonuclease BN
IOD65_03355	COG1702	phosphate starvation-inducible protein PhoH
IOD65_03365	COG0739	heme binding
IOD65_03365	COG0741	lytic transglycosylase activity
IOD65_03365	COG1196	nuclear chromosome segregation
IOD65_03395	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IOD65_03400	COG1183	phosphatidylcholine synthase activity
IOD65_03445	COG1960	acyl-CoA dehydrogenase activity
IOD65_03450	COG1309	transcriptional regulator
IOD65_03465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOD65_03470	COG1960	acyl-CoA dehydrogenase activity
IOD65_03510	COG2969	positive regulation of protein catabolic process
IOD65_03520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IOD65_03525	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IOD65_03530	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IOD65_03535	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IOD65_03540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IOD65_03560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IOD65_03570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOD65_03575	COG1408	metallophosphoesterase
IOD65_03580	COG2885	chlorophyll binding
IOD65_03580	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IOD65_03585	COG2199	diguanylate cyclase activity
IOD65_03655	COG1607	acyl-coa hydrolase
IOD65_03690	COG2350	Protein conserved in bacteria
IOD65_03705	COG3781	membrane
IOD65_03715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IOD65_03720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOD65_03730	COG1862	Preprotein translocase
IOD65_03775	COG2205	protein histidine kinase activity
IOD65_03775	COG5002	protein histidine kinase activity
IOD65_03775	COG0784	Response regulator, receiver
IOD65_03780	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IOD65_03795	COG0726	polysaccharide deacetylase
IOD65_03810	COG1216	Glycosyl transferase, family 2
IOD65_03860	COG0625	glutathione transferase activity
IOD65_03865	COG0583	DNA-binding transcription factor activity
IOD65_03870	COG1960	acyl-CoA dehydrogenase activity
IOD65_03875	COG1960	acyl-CoA dehydrogenase activity
IOD65_03885	COG2205	protein histidine kinase activity
IOD65_03890	COG0745	RESPONSE REGULATOR receiver
IOD65_03900	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IOD65_03920	COG2096	Adenosyltransferase
IOD65_03925	COG4206	TonB-dependent receptor
IOD65_03970	COG0285	dihydrofolate synthase activity
IOD65_03990	COG0450	alkyl hydroperoxide reductase
IOD65_04005	COG0477	Major facilitator Superfamily
IOD65_04010	COG1272	protein, Hemolysin III
IOD65_04020	COG2153	protein acetylation
IOD65_04040	COG0183	Belongs to the thiolase family
IOD65_04045	COG2207	Transcriptional regulator
IOD65_04065	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD65_04085	COG0183	Belongs to the thiolase family
IOD65_04095	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IOD65_04095	COG2885	chlorophyll binding
IOD65_04105	COG1690	Belongs to the RtcB family
IOD65_04110	COG0833	amino acid
IOD65_04120	COG2233	PERMEase
IOD65_04125	COG1217	gtp-binding protein TYPA
IOD65_04150	COG2094	Belongs to the DNA glycosylase MPG family
IOD65_04155	COG4772	TonB-dependent receptor
IOD65_04160	COG1902	pentaerythritol trinitrate reductase activity
IOD65_04175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOD65_04180	COG0354	folic acid binding
IOD65_04200	COG2233	PERMEase
IOD65_04205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOD65_04210	COG0251	oxidation-reduction process
IOD65_04215	COG1335	isochorismatase
IOD65_04220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD65_04225	COG0778	Nitroreductase
IOD65_04230	COG0596	Alpha beta hydrolase
IOD65_04235	COG3189	MarR family transcriptional regulator
IOD65_04240	COG2824	Alkylphosphonate utilization operon protein PhnA
IOD65_04245	COG3422	double-strand break repair
IOD65_04285	COG0840	transmembrane signaling receptor activity
IOD65_04310	COG2826	transposase and inactivated derivatives, IS30 family
IOD65_04315	COG2826	transposase and inactivated derivatives, IS30 family
IOD65_04330	COG5510	response to toxic substance
IOD65_04340	COG2832	Protein of unknown function (DUF454)
IOD65_04345	COG1376	ErfK ybiS ycfS ynhG family protein
IOD65_04385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IOD65_04395	COG1289	transmembrane transporter activity
IOD65_04400	COG2814	Major facilitator Superfamily
IOD65_04420	COG1115	amino acid carrier protein
IOD65_04425	COG1752	Esterase of the alpha-beta hydrolase superfamily
IOD65_04430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOD65_04435	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IOD65_04440	COG3590	peptidase
IOD65_04465	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IOD65_04475	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IOD65_04480	COG1077	Cell shape determining protein MreB Mrl
IOD65_04485	COG1792	Involved in formation and maintenance of cell shape
IOD65_04490	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IOD65_04495	COG0424	maF-like protein
IOD65_04500	COG1530	ribonuclease E activity
IOD65_04510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD65_04530	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOD65_04555	COG2207	Transcriptional regulator
IOD65_04575	COG0464	growth
IOD65_04625	COG0305	Participates in initiation and elongation during chromosome replication
IOD65_04660	COG0582	viral genome integration into host DNA
IOD65_04680	COG3046	protein related to deoxyribodipyrimidine photolyase
IOD65_04690	COG1113	amino acid transport
IOD65_04695	COG2828	Protein conserved in bacteria
IOD65_04700	COG0142	geranyltranstransferase activity
IOD65_04705	COG2315	Protein conserved in bacteria
IOD65_04720	COG1752	Esterase of the alpha-beta hydrolase superfamily
IOD65_04745	COG2194	sulfuric ester hydrolase activity
IOD65_04750	COG0745	RESPONSE REGULATOR receiver
IOD65_04755	COG0642	Histidine kinase
IOD65_04765	COG0004	ammonium transporteR
IOD65_04770	COG0583	DNA-binding transcription factor activity
IOD65_04800	COG0525	valine-tRNA ligase activity
IOD65_04810	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_04820	COG0393	Putative heavy-metal-binding
IOD65_04825	COG0393	Putative heavy-metal-binding
IOD65_04830	COG1538	Outer membrane efflux protein
IOD65_04840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD65_04845	COG0671	phosphoesterase, PA-phosphatase related
IOD65_04870	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IOD65_04885	COG1648	precorrin-2 dehydrogenase activity
IOD65_04885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IOD65_04890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IOD65_04925	COG0531	amino acid
IOD65_04940	COG0321	lipoyl(octanoyl) transferase activity
IOD65_04945	COG2921	Belongs to the UPF0250 family
IOD65_04985	COG2009	succinate dehydrogenase
IOD65_04990	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IOD65_04995	COG1053	succinate dehydrogenase
IOD65_05000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IOD65_05025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD65_05045	COG2354	Protein conserved in bacteria
IOD65_05050	COG2321	neutral zinc metallopeptidase
IOD65_05070	COG2826	transposase and inactivated derivatives, IS30 family
IOD65_05080	COG2843	Capsule synthesis protein
IOD65_05100	COG0589	response to stress
IOD65_05110	COG0251	oxidation-reduction process
IOD65_05115	COG1309	transcriptional regulator
IOD65_05130	COG0505	Belongs to the CarA family
IOD65_05160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOD65_05165	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IOD65_05215	COG0477	Major facilitator Superfamily
IOD65_05220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IOD65_05235	COG1597	lipid kinase activity
IOD65_05240	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IOD65_05270	COG0584	glycerophosphoryl diester phosphodiesterase
IOD65_05290	COG0741	lytic transglycosylase activity
IOD65_05310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IOD65_05320	COG0582	viral genome integration into host DNA
IOD65_05395	COG3328	transposase activity
IOD65_05440	COG2814	Major facilitator Superfamily
IOD65_05455	COG1230	cation diffusion facilitator family transporter
IOD65_05465	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IOD65_05475	COG2059	Chromate
IOD65_05495	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_05505	COG0583	DNA-binding transcription factor activity
IOD65_05530	COG0406	alpha-ribazole phosphatase activity
IOD65_05550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD65_05560	COG0778	Nitroreductase
IOD65_05575	COG1929	Belongs to the glycerate kinase type-1 family
IOD65_05580	COG0243	molybdopterin cofactor binding
IOD65_05585	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IOD65_05600	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IOD65_05615	COG1115	amino acid carrier protein
IOD65_05620	COG1113	amino acid transport
IOD65_05630	COG0019	diaminopimelate decarboxylase activity
IOD65_05640	COG1280	lysine exporter protein (LysE YggA)
IOD65_05645	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IOD65_05675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD65_05705	COG4591	ABC-type transport system involved in lipoprotein release permease component
IOD65_05710	COG1136	(ABC) transporter
IOD65_05715	COG0658	competence protein
IOD65_05715	COG2333	competence protein COMEC
IOD65_05725	COG0616	signal peptide processing
IOD65_05725	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IOD65_05730	COG0596	Alpha beta hydrolase
IOD65_05735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IOD65_05745	COG0628	permease
IOD65_05780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD65_05800	COG0823	Involved in the tonB-independent uptake of proteins
IOD65_05820	COG0824	Thioesterase
IOD65_05825	COG1473	amidohydrolase
IOD65_05845	COG0047	phosphoribosylformylglycinamidine synthase activity
IOD65_05845	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IOD65_05850	COG2814	Major facilitator Superfamily
IOD65_05855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IOD65_05860	COG1024	Enoyl-CoA hydratase
IOD65_05865	COG1051	belongs to the nudix hydrolase family
IOD65_05865	COG1056	cytidyltransferase-related domain
IOD65_05880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IOD65_05895	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IOD65_05910	COG4625	pathogenesis
IOD65_05915	COG0583	DNA-binding transcription factor activity
IOD65_05920	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IOD65_05925	COG4208	sulfate ABC transporter
IOD65_05930	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IOD65_05940	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IOD65_05945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IOD65_05950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IOD65_05970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD65_05980	COG0481	GTPase activity
IOD65_05985	COG0681	Belongs to the peptidase S26 family
IOD65_05995	COG0571	ribonuclease III activity
IOD65_06000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IOD65_06010	COG1381	Involved in DNA repair and RecF pathway recombination
IOD65_06015	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IOD65_06025	COG4221	oxidoreductase activity
IOD65_06055	COG0436	Aminotransferase
IOD65_06075	COG0556	nucleotide-excision repair
IOD65_06085	COG2962	Rard protein
IOD65_06130	COG2070	2-Nitropropane dioxygenase
IOD65_06145	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IOD65_06160	COG1215	transferase activity, transferring glycosyl groups
IOD65_06175	COG0415	Belongs to the DNA photolyase family
IOD65_06185	COG1252	NADH dehydrogenase
IOD65_06190	COG1686	Belongs to the peptidase S11 family
IOD65_06205	COG1187	pseudouridine synthase activity
IOD65_06220	COG0477	Major facilitator Superfamily
IOD65_06225	COG0583	DNA-binding transcription factor activity
IOD65_06230	COG1823	symporter activity
IOD65_06240	COG0612	Peptidase, M16
IOD65_06265	COG0352	thiamine-phosphate diphosphorylase activity
IOD65_06300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD65_06315	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOD65_06320	COG0076	glutamate decarboxylase activity
IOD65_06330	COG1522	sequence-specific DNA binding
IOD65_06335	COG3961	Belongs to the TPP enzyme family
IOD65_06340	COG1113	amino acid transport
IOD65_06345	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IOD65_06350	COG0573	inorganic phosphate transmembrane transporter activity
IOD65_06360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IOD65_06365	COG0616	signal peptide processing
IOD65_06415	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IOD65_06420	COG1686	Belongs to the peptidase S11 family
IOD65_06445	COG0583	DNA-binding transcription factor activity
IOD65_06450	COG1067	ATP-dependent peptidase activity
IOD65_06455	COG2211	Major facilitator Superfamily
IOD65_06490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IOD65_06495	COG1966	Carbon starvation protein
IOD65_06500	COG2879	small protein
IOD65_06510	COG0582	viral genome integration into host DNA
IOD65_06610	COG3739	integral membrane protein
IOD65_06630	COG0302	gtp cyclohydrolase
IOD65_06640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IOD65_06650	COG2840	Smr protein MutS2
IOD65_06675	COG0512	Glutamine amidotransferase of anthranilate synthase
IOD65_06690	COG0174	glutamine synthetase
IOD65_06700	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IOD65_06735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IOD65_06740	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IOD65_06745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD65_06765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IOD65_06780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IOD65_06785	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IOD65_06800	COG1960	acyl-CoA dehydrogenase activity
IOD65_06805	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IOD65_06810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD65_06820	COG2223	nitrite transmembrane transporter activity
IOD65_06830	COG0024	Methionine aminopeptidase
IOD65_06835	COG0052	Belongs to the universal ribosomal protein uS2 family
IOD65_06850	COG2207	Transcriptional regulator
IOD65_06875	COG2951	lytic endotransglycosylase activity
IOD65_06880	COG0772	Belongs to the SEDS family
IOD65_06895	COG0842	Transport permease protein
IOD65_06900	COG1131	(ABC) transporter
IOD65_06945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD65_06955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD65_06960	COG4215	(ABC) transporter
IOD65_06965	COG4160	amino acid transport
IOD65_06970	COG4598	ABC transporter
IOD65_06980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD65_06985	COG0826	peptidase U32
IOD65_06990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD65_06995	COG0384	phenazine biosynthesis protein PhzF
IOD65_07005	COG1720	tRNA m6t6A37 methyltransferase activity
IOD65_07015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IOD65_07030	COG0642	Histidine kinase
IOD65_07040	COG0494	nUDIX hydrolase
IOD65_07050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD65_07055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IOD65_07060	COG3139	Protein of unknown function (DUF1315)
IOD65_07065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IOD65_07070	COG1301	dicarboxylic acid transport
IOD65_07075	COG1960	acyl-CoA dehydrogenase activity
IOD65_07090	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IOD65_07100	COG2195	Cleaves the N-terminal amino acid of tripeptides
IOD65_07105	COG1234	tRNA 3'-trailer cleavage
IOD65_07130	COG2363	Small membrane protein
IOD65_07150	COG0513	Belongs to the DEAD box helicase family
IOD65_07160	COG0778	Nitroreductase
IOD65_07190	COG1286	toxin biosynthetic process
IOD65_07215	COG4783	chaperone-mediated protein folding
IOD65_07220	COG1610	YqeY-like protein
IOD65_07250	COG0515	serine threonine protein kinase
IOD65_07250	COG2815	serine threonine protein kinase
IOD65_07275	COG1278	Cold shock
IOD65_07290	COG3243	poly(R)-hydroxyalkanoic acid synthase
IOD65_07295	COG0786	glutamate:sodium symporter activity
IOD65_07300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOD65_07300	COG0475	glutathione-regulated potassium exporter activity
IOD65_07325	COG2985	domain, Protein
IOD65_07335	COG2995	paraquat-inducible protein a
IOD65_07340	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IOD65_07340	COG3008	intermembrane lipid transfer
IOD65_07365	COG2351	hydroxyisourate hydrolase activity
IOD65_07405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOD65_07415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOD65_07420	COG0642	Histidine kinase
IOD65_07425	COG0745	RESPONSE REGULATOR receiver
IOD65_07440	COG1794	racemase activity, acting on amino acids and derivatives
IOD65_07450	COG2175	clavaminate synthase activity
IOD65_07455	COG3246	L-lysine catabolic process to acetate
IOD65_07460	COG2814	Major facilitator Superfamily
IOD65_07475	COG2855	membrane
IOD65_07510	COG2814	Major facilitator Superfamily
IOD65_07535	COG1301	dicarboxylic acid transport
IOD65_07545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD65_07550	COG2011	ABC-type metal ion transport system permease component
IOD65_07555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IOD65_07565	COG0151	Belongs to the GarS family
IOD65_07575	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IOD65_07605	COG2308	Evidence 4 Homologs of previously reported genes of
IOD65_07615	COG1305	Transglutaminase-like
IOD65_07625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IOD65_07630	COG0305	Participates in initiation and elongation during chromosome replication
IOD65_07655	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IOD65_07660	COG1845	cytochrome c oxidase, subunit III
IOD65_07665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IOD65_07695	COG0726	polysaccharide deacetylase
IOD65_07695	COG1649	PFAM Uncharacterised BCR, COG1649
IOD65_07700	COG1215	transferase activity, transferring glycosyl groups
IOD65_07705	COG3658	cytochrome
IOD65_07715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD65_07730	COG0583	DNA-binding transcription factor activity
IOD65_07745	COG2890	protein-(glutamine-N5) methyltransferase activity
IOD65_07750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD65_07755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOD65_07770	COG1960	acyl-CoA dehydrogenase activity
IOD65_07775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOD65_07790	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IOD65_07800	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IOD65_07805	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IOD65_07815	COG2205	protein histidine kinase activity
IOD65_07820	COG0745	RESPONSE REGULATOR receiver
IOD65_07825	COG0174	glutamine synthetase
IOD65_07840	COG0477	Major facilitator Superfamily
IOD65_07845	COG0729	surface antigen
IOD65_07875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOD65_07880	COG2814	Major facilitator Superfamily
IOD65_07895	COG0583	DNA-binding transcription factor activity
IOD65_07915	COG1187	pseudouridine synthase activity
IOD65_07930	COG0564	pseudouridine synthase activity
IOD65_07935	COG0802	atpase or kinase
IOD65_07940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IOD65_07950	COG1923	regulation of RNA biosynthetic process
IOD65_07955	COG0697	spore germination
IOD65_07970	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOD65_07980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IOD65_07985	COG0519	Catalyzes the synthesis of GMP from XMP
IOD65_07985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IOD65_07990	COG4302	ethanolamine ammonia-lyase activity
IOD65_07995	COG4303	Ethanolamine ammonia lyase large subunit
IOD65_08000	COG0531	amino acid
IOD65_08020	COG1454	alcohol dehydrogenase
IOD65_08025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IOD65_08050	COG0308	aminopeptidase N
IOD65_08090	COG1605	Chorismate mutase
IOD65_08105	COG4772	TonB-dependent receptor
IOD65_08170	COG0583	DNA-binding transcription factor activity
IOD65_08205	COG0488	(ABC) transporter
IOD65_08210	COG0589	response to stress
IOD65_08230	COG3135	benzoate transporter
IOD65_08235	COG1522	sequence-specific DNA binding
IOD65_08245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IOD65_08250	COG0583	DNA-binding transcription factor activity
IOD65_08260	COG0183	Belongs to the thiolase family
IOD65_08270	COG2030	dehydratase
IOD65_08275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD65_08300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IOD65_08310	COG0824	Thioesterase
IOD65_08315	COG1454	alcohol dehydrogenase
IOD65_08340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IOD65_08370	COG0069	glutamate synthase activity
IOD65_08395	COG2814	Major facilitator Superfamily
IOD65_08410	COG0511	ligase activity, forming carbon-carbon bonds
IOD65_08435	COG4264	IucA IucC family
IOD65_08445	COG4264	IucA IucC family
IOD65_08450	COG2423	ornithine cyclodeaminase activity
IOD65_08455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD65_08465	COG1116	anion transmembrane transporter activity
IOD65_08465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOD65_08480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD65_08480	COG2146	nitrite reductase [NAD(P)H] activity
IOD65_08485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD65_08490	COG0243	molybdopterin cofactor binding
IOD65_08500	COG0243	molybdopterin cofactor binding
IOD65_08505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IOD65_08520	COG0315	cyclic pyranopterin monophosphate synthase activity
IOD65_08520	COG0521	Mo-molybdopterin cofactor biosynthetic process
IOD65_08525	COG0303	'Molybdopterin
IOD65_08535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD65_08540	COG0697	spore germination
IOD65_08565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IOD65_08630	COG2204	response regulator
IOD65_08635	COG3852	Histidine kinase
IOD65_08660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IOD65_08665	COG0575	Belongs to the CDS family
IOD65_08700	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOD65_08715	COG2137	regulation of response to DNA damage stimulus
IOD65_08725	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IOD65_08730	COG1011	Hydrolase
IOD65_08745	COG1522	sequence-specific DNA binding
IOD65_08755	COG1113	amino acid transport
IOD65_08775	COG0659	secondary active sulfate transmembrane transporter activity
IOD65_08800	COG2826	transposase and inactivated derivatives, IS30 family
IOD65_08815	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IOD65_08815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD65_08815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD65_08820	COG1105	Belongs to the carbohydrate kinase PfkB family
IOD65_08825	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD65_08825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOD65_08845	COG3193	protein, possibly involved in utilization of glycolate and propanediol
IOD65_08855	COG0024	Methionine aminopeptidase
IOD65_08860	COG0583	DNA-binding transcription factor activity
IOD65_08870	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IOD65_08875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOD65_08880	COG0517	IMP dehydrogenase activity
IOD65_08880	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IOD65_08905	COG0552	protein localization to endoplasmic reticulum
IOD65_08915	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IOD65_08930	COG4890	Cyd operon protein YbgT
IOD65_08935	COG1294	oxidase, subunit
IOD65_08950	COG1585	Membrane protein implicated in regulation of membrane protease activity
IOD65_08960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD65_08975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IOD65_08980	COG0569	domain protein
IOD65_08985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOD65_09015	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IOD65_09020	COG0542	response to heat
IOD65_09045	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOD65_09045	COG1902	pentaerythritol trinitrate reductase activity
IOD65_09085	COG0148	phosphopyruvate hydratase activity
IOD65_09090	COG2323	membrane
IOD65_09100	COG2826	transposase and inactivated derivatives, IS30 family
IOD65_09140	COG0776	regulation of translation
IOD65_09165	COG3409	Peptidoglycan-binding domain 1 protein
IOD65_09165	COG3267	Type II secretory pathway component ExeA
IOD65_09190	COG0681	Belongs to the peptidase S26 family
IOD65_09225	COG4373	Mu-like prophage FluMu protein gp28
IOD65_09240	COG4383	Mu-like prophage protein gp29
IOD65_09245	COG2369	cell adhesion
IOD65_09350	COG4773	Receptor
IOD65_09355	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IOD65_09365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IOD65_09370	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IOD65_09375	COG0183	Belongs to the thiolase family
IOD65_09380	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IOD65_09385	COG0596	Alpha beta hydrolase
IOD65_09390	COG2271	Major facilitator Superfamily
IOD65_09395	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD65_09400	COG3485	protocatechuate 3,4-dioxygenase
IOD65_09405	COG3485	protocatechuate 3,4-dioxygenase
IOD65_09410	COG0710	3-dehydroquinate dehydratase activity
IOD65_09415	COG3420	alginic acid biosynthetic process
IOD65_09420	COG3659	wide pore channel activity
IOD65_09425	COG4993	Dehydrogenase
IOD65_09435	COG2391	methyltransferase activity
IOD65_09450	COG1414	Transcriptional regulator
IOD65_09455	COG0583	DNA-binding transcription factor activity
IOD65_09460	COG1960	acyl-CoA dehydrogenase activity
IOD65_09485	COG2814	Major facilitator Superfamily
IOD65_09495	COG0154	amidase activity
IOD65_09515	COG4638	Rieske (2fe-2S)
IOD65_09525	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_09535	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOD65_09545	COG3733	amine oxidase
IOD65_09555	COG1012	belongs to the aldehyde dehydrogenase family
IOD65_09560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOD65_09565	COG0183	Belongs to the thiolase family
IOD65_09570	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IOD65_09575	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IOD65_09585	COG4829	muconolactone delta-isomerase
IOD65_09590	COG4948	Mandelate Racemase Muconate Lactonizing
IOD65_09595	COG0583	DNA-binding transcription factor activity
IOD65_09605	COG2186	Transcriptional regulator
IOD65_09625	COG1012	belongs to the aldehyde dehydrogenase family
IOD65_09630	COG2351	hydroxyisourate hydrolase activity
IOD65_09635	COG2233	PERMEase
IOD65_09645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD65_09650	COG2186	Transcriptional regulator
IOD65_09660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOD65_09670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD65_09690	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOD65_09690	COG1902	pentaerythritol trinitrate reductase activity
IOD65_09730	COG1309	transcriptional regulator
IOD65_09735	COG0583	DNA-binding transcription factor activity
IOD65_09740	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_09745	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_09750	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_09760	COG1960	acyl-CoA dehydrogenase activity
IOD65_09770	COG0318	PFAM AMP-dependent synthetase and ligase
IOD65_09800	COG0583	DNA-binding transcription factor activity
IOD65_09825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IOD65_09830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IOD65_09880	COG1012	belongs to the aldehyde dehydrogenase family
IOD65_09885	COG0129	dihydroxy-acid dehydratase activity
IOD65_09895	COG0583	DNA-binding transcription factor activity
IOD65_09900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD65_09910	COG2084	Dehydrogenase
IOD65_09925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD65_09930	COG1120	ATPase activity
IOD65_09950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IOD65_10000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IOD65_10030	COG2856	Zn peptidase
IOD65_10080	COG3539	Fimbrial protein
IOD65_10105	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IOD65_10115	COG0753	catalase activity
IOD65_10135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOD65_10145	COG2205	protein histidine kinase activity
IOD65_10150	COG0745	RESPONSE REGULATOR receiver
IOD65_10155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD65_10160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD65_10215	COG1535	isochorismatase
IOD65_10215	COG3433	isochorismatase activity
IOD65_10220	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_10225	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IOD65_10230	COG4149	molybdate abc transporter
IOD65_10235	COG0725	ABC transporter, periplasmic molybdate-binding protein
IOD65_10245	COG4638	Rieske (2fe-2S)
IOD65_10250	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IOD65_10255	COG0543	2 iron, 2 sulfur cluster binding
IOD65_10255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD65_10270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOD65_10280	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_10295	COG2207	Transcriptional regulator
IOD65_10300	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_10305	COG2610	gluconate transmembrane transporter activity
IOD65_10345	COG0583	DNA-binding transcription factor activity
IOD65_10360	COG2031	fatty acid transporter
IOD65_10365	COG0183	Belongs to the thiolase family
IOD65_10370	COG0583	DNA-binding transcription factor activity
IOD65_10375	COG0583	DNA-binding transcription factor activity
IOD65_10390	COG1027	Aspartate ammonia-lyase
IOD65_10400	COG0477	Major facilitator Superfamily
IOD65_10410	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IOD65_10415	COG1733	regulation of RNA biosynthetic process
IOD65_10420	COG2207	Transcriptional regulator
IOD65_10420	COG3708	Transcriptional regulator
IOD65_10435	COG0730	response to heat
IOD65_10455	COG3781	membrane
IOD65_10460	COG1063	alcohol dehydrogenase
IOD65_10470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD65_10475	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD65_10480	COG0022	dehydrogenase e1 component
IOD65_10485	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IOD65_10490	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IOD65_10505	COG3706	GGDEF domain
IOD65_10530	COG0133	tryptophan synthase activity
IOD65_10540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOD65_10570	COG0583	DNA-binding transcription factor activity
IOD65_10575	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IOD65_10585	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IOD65_10645	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOD65_10650	COG4773	Receptor
IOD65_10670	COG0730	response to heat
IOD65_10675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IOD65_10695	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IOD65_10710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD65_10720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IOD65_10735	COG1960	acyl-CoA dehydrogenase activity
IOD65_10740	COG1960	acyl-CoA dehydrogenase activity
IOD65_10745	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD65_10750	COG2207	Transcriptional regulator
IOD65_10755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOD65_10760	COG0776	regulation of translation
IOD65_10785	COG0822	iron-sulfur transferase activity
IOD65_10790	COG0316	Belongs to the HesB IscA family
IOD65_10820	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IOD65_10840	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IOD65_10845	COG0702	epimerase
IOD65_10890	COG0339	signal peptide processing
IOD65_10895	COG4166	transmembrane transport
IOD65_10940	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IOD65_10945	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IOD65_10960	COG2431	L-lysine efflux transmembrane transporter activity
IOD65_10975	COG0776	regulation of translation
IOD65_11040	COG0084	hydrolase, TatD family'
IOD65_11060	COG1663	tetraacyldisaccharide 4'-kinase activity
IOD65_11065	COG1132	(ABC) transporter
IOD65_11075	COG0811	peptide transport
IOD65_11080	COG1475	DNA binding
IOD65_11085	COG1192	Involved in chromosome partitioning
IOD65_11095	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IOD65_11100	COG3178	'Phosphotransferase
IOD65_11110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOD65_11135	COG0424	maF-like protein
IOD65_11140	COG2850	peptidyl-arginine hydroxylation
IOD65_11150	COG0640	Transcriptional regulator
IOD65_11160	COG3619	membrane
IOD65_11165	COG3122	Protein conserved in bacteria
IOD65_11170	COG1132	(ABC) transporter
IOD65_11175	COG2826	transposase and inactivated derivatives, IS30 family
IOD65_11195	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IOD65_11210	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IOD65_11210	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IOD65_11210	COG0506	proline dehydrogenase activity
IOD65_11215	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IOD65_11230	COG3698	Phosphodiester glycosidase
IOD65_11240	COG2353	YceI-like domain
IOD65_11250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IOD65_11295	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IOD65_11295	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IOD65_11320	COG3539	Fimbrial protein
IOD65_11355	COG0583	DNA-binding transcription factor activity
IOD65_11360	COG0697	spore germination
IOD65_11370	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IOD65_11380	COG0583	DNA-binding transcription factor activity
IOD65_11395	COG1309	transcriptional regulator
IOD65_11410	COG1522	sequence-specific DNA binding
IOD65_11420	COG1126	abc transporter atp-binding protein
IOD65_11425	COG0765	amino acid transport
IOD65_11430	COG0765	amino acid transport
IOD65_11465	COG1464	Belongs to the NlpA lipoprotein family
IOD65_11475	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IOD65_11480	COG2011	ABC-type metal ion transport system permease component
IOD65_11485	COG0012	GTP binding
IOD65_11510	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IOD65_11545	COG2207	Transcriptional regulator
IOD65_11545	COG1917	Cupin 2, conserved barrel domain protein
IOD65_11550	COG0386	Belongs to the glutathione peroxidase family
IOD65_11560	COG0436	Aminotransferase
IOD65_11565	COG1301	dicarboxylic acid transport
IOD65_11600	COG3634	alkyl hydroperoxide reductase activity
IOD65_11615	COG0583	DNA-binding transcription factor activity
IOD65_11620	COG0431	NADPH-dependent FMN reductase
IOD65_11625	COG0798	PFAM Bile acid sodium symporter
IOD65_11650	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IOD65_11660	COG0583	DNA-binding transcription factor activity
IOD65_11670	COG2826	transposase and inactivated derivatives, IS30 family
IOD65_11685	COG2175	clavaminate synthase activity
IOD65_11690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD65_11695	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IOD65_11700	COG4521	taurine ABC transporter
IOD65_11710	COG0477	Major facilitator Superfamily
IOD65_11715	COG2826	transposase and inactivated derivatives, IS30 family
IOD65_11735	COG1271	oxidase subunit
IOD65_11740	COG1294	oxidase, subunit
IOD65_11750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD65_11770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IOD65_11790	COG3052	prosthetic group binding
IOD65_11795	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
IOD65_11805	COG0583	DNA-binding transcription factor activity
IOD65_11810	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_11815	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD65_11825	COG2814	Major facilitator Superfamily
IOD65_11830	COG0300	oxidoreductase activity
IOD65_11855	COG1346	cytolysis
IOD65_11865	COG0583	DNA-binding transcription factor activity
IOD65_11870	COG0625	glutathione transferase activity
IOD65_11875	COG0625	glutathione transferase activity
IOD65_11895	COG0583	DNA-binding transcription factor activity
IOD65_11900	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_11910	COG1045	serine acetyltransferase
IOD65_11915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOD65_11920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IOD65_11925	COG1280	lysine exporter protein (LysE YggA)
IOD65_11940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD65_11945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD65_11955	COG0765	amino acid transport
IOD65_11960	COG0765	amino acid transport
IOD65_11980	COG0784	Response regulator, receiver
IOD65_11980	COG2205	protein histidine kinase activity
IOD65_12000	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOD65_12020	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_12065	COG0583	DNA-binding transcription factor activity
IOD65_12075	COG2814	Major facilitator Superfamily
IOD65_12090	COG0318	PFAM AMP-dependent synthetase and ligase
IOD65_12095	COG1309	transcriptional regulator
IOD65_12100	COG1960	acyl-CoA dehydrogenase activity
IOD65_12105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOD65_12110	COG1024	Enoyl-CoA hydratase
IOD65_12115	COG4770	biotin carboxylase activity
IOD65_12125	COG0583	DNA-binding transcription factor activity
IOD65_12140	COG1960	acyl-CoA dehydrogenase activity
IOD65_12150	COG2814	Major facilitator Superfamily
IOD65_12160	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IOD65_12165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IOD65_12170	COG2814	Major facilitator Superfamily
IOD65_12175	COG1960	acyl-CoA dehydrogenase activity
IOD65_12180	COG1024	Enoyl-CoA hydratase
IOD65_12185	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_12190	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD65_12195	COG0183	Belongs to the thiolase family
IOD65_12215	COG1024	Enoyl-CoA hydratase
IOD65_12225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD65_12230	COG1960	acyl-CoA dehydrogenase activity
IOD65_12235	COG2814	Major facilitator Superfamily
IOD65_12240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD65_12245	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IOD65_12260	COG3842	ATPase activity
IOD65_12265	COG1840	ABC-type Fe3 transport system, periplasmic component
IOD65_12280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD65_12285	COG1414	Transcriptional regulator
IOD65_12295	COG0583	DNA-binding transcription factor activity
IOD65_12320	COG2050	protein possibly involved in aromatic compounds catabolism
IOD65_12330	COG3327	negative regulation of DNA-templated transcription, initiation
IOD65_12335	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IOD65_12340	COG0183	Belongs to the thiolase family
IOD65_12345	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD65_12350	COG1024	Enoyl-CoA hydratase
IOD65_12355	COG1024	Enoyl-CoA hydratase
IOD65_12360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD65_12365	COG2151	metal-sulfur cluster biosynthetic enzyme
IOD65_12370	COG3396	Phenylacetate-CoA oxygenase
IOD65_12375	COG3460	Phenylacetate-CoA oxygenase
IOD65_12380	COG3396	Phenylacetate-CoA oxygenase
IOD65_12385	COG1012	belongs to the aldehyde dehydrogenase family
IOD65_12385	COG2030	dehydratase
IOD65_12390	COG1760	l-serine dehydratase
IOD65_12405	COG0789	Transcriptional regulator
IOD65_12415	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IOD65_12420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD65_12435	COG2807	transmembrane transport
IOD65_12440	COG0590	tRNA wobble adenosine to inosine editing
IOD65_12460	COG1063	alcohol dehydrogenase
IOD65_12465	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD65_12495	COG3210	domain, Protein
IOD65_12500	COG2831	hemolysin activation secretion protein
IOD65_12505	COG0038	chloride channel
IOD65_12510	COG4770	biotin carboxylase activity
IOD65_12530	COG1914	H( )-stimulated, divalent metal cation uptake system
IOD65_12535	COG0583	DNA-binding transcription factor activity
IOD65_12545	COG1595	DNA-templated transcription, initiation
IOD65_12555	COG3220	belongs to the UPF0276 family
IOD65_12605	COG0702	epimerase
IOD65_12610	COG1733	regulation of RNA biosynthetic process
IOD65_12625	COG1051	belongs to the nudix hydrolase family
IOD65_12635	COG1595	DNA-templated transcription, initiation
IOD65_12640	COG3712	iron ion homeostasis
IOD65_12685	COG3038	cytochrome b561
IOD65_12690	COG0753	catalase activity
IOD65_12695	COG1733	regulation of RNA biosynthetic process
IOD65_12705	COG1469	GTP cyclohydrolase I activity
IOD65_12710	COG4451	ribulose bisphosphate carboxylase, small
IOD65_12710	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IOD65_12715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IOD65_12730	COG1522	sequence-specific DNA binding
IOD65_12735	COG0531	amino acid
IOD65_12740	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IOD65_12755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOD65_12770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IOD65_12780	COG4122	O-methyltransferase activity
IOD65_12790	COG0110	maltose O-acetyltransferase activity
IOD65_12810	COG1538	Outer membrane efflux protein
IOD65_12815	COG1137	ATPase activity
IOD65_12820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IOD65_12830	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IOD65_12885	COG2814	Major facilitator Superfamily
IOD65_12895	COG0668	transmembrane transport
IOD65_12940	COG1309	transcriptional regulator
IOD65_12960	COG2226	methyltransferase
IOD65_12985	COG1278	Cold shock
IOD65_12990	COG1560	Kdo2-lipid A biosynthetic process
IOD65_13000	COG2826	transposase and inactivated derivatives, IS30 family
IOD65_13040	COG1570	exodeoxyribonuclease VII activity
IOD65_13125	COG2871	sodium ion transport
IOD65_13135	COG0583	DNA-binding transcription factor activity
IOD65_13145	COG4638	Rieske (2fe-2S)
IOD65_13150	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IOD65_13155	COG0543	2 iron, 2 sulfur cluster binding
IOD65_13155	COG0633	Ferredoxin
IOD65_13160	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_13165	COG3135	benzoate transporter
IOD65_13170	COG2814	Major facilitator Superfamily
IOD65_13185	COG1643	Atp-dependent helicase
IOD65_13210	COG3634	alkyl hydroperoxide reductase activity
IOD65_13230	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IOD65_13240	COG0625	glutathione transferase activity
IOD65_13250	COG2885	chlorophyll binding
IOD65_13285	COG0542	response to heat
IOD65_13300	COG1765	OsmC-like protein
IOD65_13315	COG0667	Aldo Keto reductase
IOD65_13330	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IOD65_13340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IOD65_13350	COG0582	viral genome integration into host DNA
IOD65_13365	COG3293	Transposase
IOD65_13370	COG1063	alcohol dehydrogenase
IOD65_13445	COG1598	PFAM Uncharacterised protein family UPF0150
IOD65_13560	COG5410	chromosome segregation
IOD65_13710	COG0527	aspartate kinase activity
IOD65_13720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IOD65_13730	COG3038	cytochrome b561
IOD65_13735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IOD65_13740	COG2252	PERMEase
IOD65_13750	COG1741	Belongs to the pirin family
IOD65_13755	COG1309	transcriptional regulator
IOD65_13770	COG2072	flavoprotein involved in K transport
IOD65_13775	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IOD65_13805	COG1944	ATP diphosphatase activity
IOD65_13825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IOD65_13840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD65_13855	COG2814	Major facilitator Superfamily
IOD65_13860	COG1024	Enoyl-CoA hydratase
IOD65_13865	COG1012	belongs to the aldehyde dehydrogenase family
IOD65_13900	COG2186	Transcriptional regulator
IOD65_13905	COG1012	belongs to the aldehyde dehydrogenase family
IOD65_13915	COG4948	Mandelate Racemase Muconate Lactonizing
IOD65_13920	COG2271	Major facilitator Superfamily
IOD65_13925	COG2721	sulfolactate sulfo-lyase activity
IOD65_13930	COG0697	spore germination
IOD65_13960	COG2831	hemolysin activation secretion protein
IOD65_13965	COG1113	amino acid transport
IOD65_13985	COG1012	belongs to the aldehyde dehydrogenase family
IOD65_14005	COG0531	amino acid
IOD65_14015	COG1113	amino acid transport
IOD65_14060	COG4269	membrane
IOD65_14085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD65_14090	COG0183	Belongs to the thiolase family
IOD65_14095	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD65_14100	COG1024	Enoyl-CoA hydratase
IOD65_14105	COG1960	acyl-CoA dehydrogenase activity
IOD65_14110	COG0644	oxidoreductase
IOD65_14110	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IOD65_14280	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOD65_14280	COG1902	pentaerythritol trinitrate reductase activity
IOD65_14290	COG4251	negative regulation of phosphorylation
IOD65_14290	COG5001	Diguanylate cyclase
IOD65_14290	COG3706	GGDEF domain
IOD65_14290	COG2203	Gaf domain
IOD65_14300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IOD65_14325	COG4172	Belongs to the ABC transporter superfamily
IOD65_14330	COG4239	(ABC) transporter, permease
IOD65_14335	COG4174	ABC transporter (Permease)
IOD65_14340	COG4166	transmembrane transport
IOD65_14345	COG1388	LysM domain
IOD65_14345	COG0741	lytic transglycosylase activity
IOD65_14385	COG0583	DNA-binding transcription factor activity
IOD65_14390	COG1279	arginine transmembrane transporter activity
IOD65_14400	COG0789	Transcriptional regulator
IOD65_14410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD65_14415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD65_14420	COG0006	proline dipeptidase activity
IOD65_14460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IOD65_14475	COG3384	dioxygenase
IOD65_14485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IOD65_14490	COG2878	Part of a membrane complex involved in electron transport
IOD65_14495	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IOD65_14520	COG0768	penicillin binding
IOD65_14525	COG0742	ribosomal rna small subunit methyltransferase
IOD65_14540	COG0830	nickel cation binding
IOD65_14550	COG0804	urea catabolic process
IOD65_14580	COG3015	lipoprotein NlpE involved in copper resistance
IOD65_14595	COG1253	flavin adenine dinucleotide binding
IOD65_14600	COG2851	Citrate transporter
IOD65_14650	COG1773	rubredoxin
IOD65_14655	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD65_14660	COG0596	Alpha beta hydrolase
IOD65_14665	COG0583	DNA-binding transcription factor activity
IOD65_14695	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IOD65_14700	COG4181	ATPase activity
IOD65_14745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IOD65_14765	COG0306	phosphate transporter
IOD65_14785	COG3958	Transketolase
IOD65_14790	COG3959	Transketolase, thiamine diphosphate binding domain
IOD65_14795	COG2271	Major facilitator Superfamily
IOD65_14800	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_14805	COG0583	DNA-binding transcription factor activity
IOD65_14820	COG2223	nitrite transmembrane transporter activity
IOD65_14825	COG2207	Transcriptional regulator
IOD65_14830	COG2066	Belongs to the glutaminase family
IOD65_14835	COG0242	peptide deformylase activity
IOD65_14840	COG0477	Major facilitator Superfamily
IOD65_14850	COG0028	Belongs to the TPP enzyme family
IOD65_14865	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_14870	COG2267	carboxylic ester hydrolase activity
IOD65_14880	COG2271	Major facilitator Superfamily
IOD65_14895	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_14915	COG1414	Transcriptional regulator
IOD65_14930	COG1024	Enoyl-CoA hydratase
IOD65_14940	COG1215	transferase activity, transferring glycosyl groups
IOD65_14945	COG1649	PFAM Uncharacterised BCR, COG1649
IOD65_14945	COG0726	polysaccharide deacetylase
IOD65_14955	COG4681	YaeQ
IOD65_14965	COG0523	cobalamin synthesis protein
IOD65_14975	COG1607	acyl-coa hydrolase
IOD65_14985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOD65_14990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOD65_14995	COG1309	transcriptional regulator
IOD65_15020	COG2040	homocysteine
IOD65_15025	COG0531	amino acid
IOD65_15075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD65_15080	COG0477	Major facilitator Superfamily
IOD65_15120	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IOD65_15145	COG0405	Gamma-glutamyltransferase
IOD65_15150	COG2814	Major facilitator Superfamily
IOD65_15160	COG2050	protein possibly involved in aromatic compounds catabolism
IOD65_15175	COG1090	epimerase
IOD65_15195	COG0420	3'-5' exonuclease activity
IOD65_15220	COG0735	belongs to the Fur family
IOD65_15225	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD65_15230	COG2914	Belongs to the UPF0125 (RnfH) family
IOD65_15245	COG0121	glutamine amidotransferase
IOD65_15260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOD65_15270	COG0210	DNA helicase
IOD65_15275	COG2885	chlorophyll binding
IOD65_15280	COG0204	Acyl-transferase
IOD65_15295	COG2894	cell division
IOD65_15310	COG1280	lysine exporter protein (LysE YggA)
IOD65_15315	COG1674	ftsk spoiiie
IOD65_15320	COG0492	ferredoxin-NADP+ reductase activity
IOD65_15325	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IOD65_15335	COG0456	acetyltransferase
IOD65_15350	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IOD65_15355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IOD65_15365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IOD65_15380	COG1981	membrane
IOD65_15390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IOD65_15390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IOD65_15410	COG1012	belongs to the aldehyde dehydrogenase family
IOD65_15415	COG4638	Rieske (2fe-2S)
IOD65_15420	COG0657	acetylesterase activity
IOD65_15430	COG0473	3-isopropylmalate dehydrogenase activity
IOD65_15435	COG0583	DNA-binding transcription factor activity
IOD65_15455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD65_15490	COG0358	DNA primase activity
IOD65_15505	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IOD65_15535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IOD65_15565	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOD65_15575	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IOD65_15575	COG0352	thiamine-phosphate diphosphorylase activity
IOD65_15575	COG0351	phosphomethylpyrimidine kinase
IOD65_15580	COG1652	LysM domain
IOD65_15605	COG1399	metal-binding, possibly nucleic acid-binding protein
IOD65_15610	COG3101	peptidyl-lysine hydroxylation
IOD65_15615	COG0009	L-threonylcarbamoyladenylate synthase
IOD65_15620	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IOD65_15625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IOD65_15640	COG4106	trans-aconitate 2-methyltransferase activity
IOD65_15655	COG2226	methyltransferase
IOD65_15655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOD65_15655	COG0596	Alpha beta hydrolase
IOD65_15665	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IOD65_15670	COG2223	nitrite transmembrane transporter activity
IOD65_15690	COG1196	nuclear chromosome segregation
IOD65_15700	COG0730	response to heat
IOD65_15715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IOD65_15725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOD65_15770	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IOD65_15775	COG0489	protein tyrosine kinase activity
IOD65_15785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD65_15785	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD65_15820	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IOD65_15825	COG2081	HI0933 family
IOD65_15835	COG0668	transmembrane transport
IOD65_15855	COG0583	DNA-binding transcription factor activity
IOD65_15875	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD65_15880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IOD65_15910	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IOD65_15935	COG2199	diguanylate cyclase activity
IOD65_15950	COG0745	RESPONSE REGULATOR receiver
IOD65_15965	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOD65_15975	COG2826	transposase and inactivated derivatives, IS30 family
IOD65_16010	COG0110	maltose O-acetyltransferase activity
IOD65_16015	COG0438	transferase activity, transferring glycosyl groups
IOD65_16105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOD65_16120	COG0583	DNA-binding transcription factor activity
IOD65_16150	COG0583	DNA-binding transcription factor activity
IOD65_16165	COG0583	DNA-binding transcription factor activity
IOD65_16170	COG1053	succinate dehydrogenase
IOD65_16185	COG1309	transcriptional regulator
IOD65_16195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOD65_16200	COG2814	Major facilitator Superfamily
IOD65_16205	COG1960	acyl-CoA dehydrogenase activity
IOD65_16210	COG0583	DNA-binding transcription factor activity
IOD65_16215	COG1063	alcohol dehydrogenase
IOD65_16245	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IOD65_16250	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IOD65_16255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IOD65_16275	COG2132	Multicopper oxidase
IOD65_16285	COG0561	phosphatase activity
IOD65_16290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IOD65_16300	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IOD65_16315	COG1214	PFAM Peptidase M22, glycoprotease
IOD65_16375	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IOD65_16380	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IOD65_16385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IOD65_16445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IOD65_16455	COG1846	Transcriptional regulator
IOD65_16460	COG1764	response to oxidative stress
IOD65_16500	COG0037	tRNA processing
IOD65_16510	COG0248	Ppx GppA phosphatase
IOD65_16540	COG0072	phenylalanine-tRNA ligase activity
IOD65_16560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IOD65_16585	COG1238	metal cluster binding
IOD65_16590	COG0625	glutathione transferase activity
IOD65_16605	COG0318	PFAM AMP-dependent synthetase and ligase
IOD65_16610	COG3028	Belongs to the UPF0307 family
IOD65_16615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD65_16635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IOD65_16640	COG0617	tRNA 3'-terminal CCA addition
IOD65_16645	COG1555	photosystem II stabilization
IOD65_16650	COG3956	TIGRFAM MazG family protein
IOD65_16655	COG4221	oxidoreductase activity
IOD65_16660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOD65_16675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD65_16680	COG5002	protein histidine kinase activity
IOD65_16680	COG0784	Response regulator, receiver
IOD65_16680	COG2205	protein histidine kinase activity
IOD65_16685	COG1024	Enoyl-CoA hydratase
IOD65_16690	COG2084	Dehydrogenase
IOD65_16695	COG3622	Belongs to the hyi family
IOD65_16730	COG0697	spore germination
IOD65_16740	COG2814	Major facilitator Superfamily
IOD65_16770	COG2072	flavoprotein involved in K transport
IOD65_16775	COG0492	ferredoxin-NADP+ reductase activity
IOD65_16780	COG0431	NADPH-dependent FMN reductase
IOD65_16785	COG0798	PFAM Bile acid sodium symporter
IOD65_16795	COG0640	Transcriptional regulator
IOD65_16830	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD65_16855	COG2132	Multicopper oxidase
IOD65_16870	COG2205	protein histidine kinase activity
IOD65_16890	COG2826	transposase and inactivated derivatives, IS30 family
IOD65_16960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOD65_16970	COG0583	DNA-binding transcription factor activity
IOD65_16980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IOD65_16990	COG0084	hydrolase, TatD family'
IOD65_17005	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IOD65_17025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IOD65_17030	COG0440	acetolactate synthase activity
IOD65_17035	COG0028	Belongs to the TPP enzyme family
IOD65_17055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD65_17060	COG1136	(ABC) transporter
IOD65_17060	COG0577	efflux transmembrane transporter activity
IOD65_17080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IOD65_17085	COG1162	GTPase activity
IOD65_17095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IOD65_17115	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD65_17135	COG1426	Protein conserved in bacteria
IOD65_17170	COG0793	Belongs to the peptidase S41A family
IOD65_17185	COG2267	carboxylic ester hydrolase activity
IOD65_17195	COG1012	belongs to the aldehyde dehydrogenase family
IOD65_17200	COG3265	gluconokinase activity
IOD65_17210	COG0800	Aldolase
IOD65_17225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IOD65_17230	COG0857	belongs to the CobB CobQ family
IOD65_17230	COG0280	phosphate acetyltransferase
IOD65_17235	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IOD65_17235	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IOD65_17255	COG0740	serine-type endopeptidase activity
IOD65_17265	COG4774	siderophore transport
IOD65_17275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IOD65_17285	COG2813	Specifically methylates the guanine in position
IOD65_17285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOD65_17385	COG0788	formyltetrahydrofolate deformylase activity
IOD65_17410	COG4651	solute:proton antiporter activity
IOD65_17410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOD65_17430	COG0724	RNA recognition motif
IOD65_17435	COG0210	DNA helicase
IOD65_17460	COG1733	regulation of RNA biosynthetic process
IOD65_17470	COG2900	Belongs to the SlyX family
IOD65_17475	COG0488	(ABC) transporter
IOD65_17485	COG1560	Kdo2-lipid A biosynthetic process
IOD65_17495	COG1301	dicarboxylic acid transport
IOD65_17550	COG0473	3-isopropylmalate dehydrogenase activity
IOD65_17575	COG0583	DNA-binding transcription factor activity
IOD65_17615	COG0583	DNA-binding transcription factor activity
IOD65_17625	COG0625	glutathione transferase activity
IOD65_17630	COG2378	regulation of single-species biofilm formation
IOD65_17635	COG0546	phosphoglycolate phosphatase activity
IOD65_17645	COG1530	ribonuclease E activity
IOD65_17650	COG0318	PFAM AMP-dependent synthetase and ligase
IOD65_17665	COG0583	DNA-binding transcription factor activity
IOD65_17670	COG1028	Short-chain dehydrogenase reductase Sdr
IOD65_17675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IOD65_17685	COG0534	Mate efflux family protein
IOD65_17700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IOD65_17725	COG0493	'glutamate synthase
IOD65_17735	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IOD65_17740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD65_17755	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IOD65_17765	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IOD65_17765	COG0644	oxidoreductase
IOD65_17780	COG4535	Mg2 and Co2 transporter CorC
IOD65_17790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD65_17810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IOD65_17820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IOD65_17830	COG0484	heat shock protein binding
IOD65_17835	COG0789	Transcriptional regulator
IOD65_17840	COG0598	Magnesium transport protein CorA
IOD65_17845	COG1185	polyribonucleotide nucleotidyltransferase activity
IOD65_17855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD65_17860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IOD65_17865	COG1074	ATP-dependent DNA helicase activity
IOD65_17870	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IOD65_17890	COG2226	methyltransferase
IOD65_17915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IOD65_17930	COG2111	Na H antiporter
IOD65_17930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IOD65_17935	COG1006	Multisubunit Na H antiporter MnhC subunit
IOD65_17940	COG0651	ATP synthesis coupled electron transport
IOD65_17945	COG1863	multisubunit Na H antiporter MnhE subunit
IOD65_17950	COG2212	antiporter activity
IOD65_17955	COG1320	monovalent cation:proton antiporter activity
IOD65_17960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IOD65_17970	COG0195	Participates in both transcription termination and antitermination
IOD65_18020	COG0237	dephospho-CoA kinase activity
IOD65_18030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD65_18045	COG0497	DNA recombination
IOD65_18055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IOD65_18090	COG2169	Transcriptional regulator
IOD65_18090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IOD65_18095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IOD65_18170	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IOD65_18185	COG0326	Molecular chaperone. Has ATPase activity
IOD65_18205	COG2056	Na+-H+ antiporter family
IOD65_18275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IOD65_18305	COG0546	phosphoglycolate phosphatase activity
IOD65_18310	COG1716	ATPase activity
IOD65_18355	COG0181	hydroxymethylbilane synthase activity
IOD65_18365	COG3275	phosphorelay sensor kinase activity
IOD65_18385	COG1538	Outer membrane efflux protein
IOD65_18395	COG0697	spore germination
IOD65_18420	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IOD65_18425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IOD65_18430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IOD65_18435	COG0772	Belongs to the SEDS family
IOD65_18460	COG4974	Belongs to the 'phage' integrase family
IOD65_18465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOD65_18475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IOD65_18485	COG2197	response regulator
IOD65_18500	COG0793	Belongs to the peptidase S41A family
IOD65_18505	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IOD65_18510	COG0795	lipopolysaccharide-transporting ATPase activity
IOD65_18550	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IOD65_18550	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IOD65_18560	COG0004	ammonium transporteR
IOD65_18565	COG0347	Belongs to the P(II) protein family
IOD65_18575	COG0606	chelatase, subunit chli
IOD65_18580	COG0431	NADPH-dependent FMN reductase
IOD65_18585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD65_18590	COG0235	Class ii aldolase
IOD65_18595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD65_18615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IOD65_18630	COG0318	PFAM AMP-dependent synthetase and ligase
IOD65_18640	COG0477	Major facilitator Superfamily
IOD65_18645	COG2860	membrane
IOD65_18655	COG1253	flavin adenine dinucleotide binding
IOD65_18665	COG2814	Major facilitator Superfamily
IOD65_18675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IOD65_18715	COG0655	NAD(P)H dehydrogenase (quinone) activity
IOD65_18730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD65_18760	COG1309	transcriptional regulator
IOD65_18795	COG0758	DNA mediated transformation
IOD65_18805	COG0697	spore germination
IOD65_18810	COG1309	transcriptional regulator
IOD65_18820	COG1373	ATPase (AAA superfamily
IOD65_18900	COG2184	nucleotidyltransferase activity
IOD65_18955	COG1309	transcriptional regulator
IOD65_18980	COG0633	Ferredoxin
IOD65_18985	COG2207	Transcriptional regulator
IOD65_19020	COG2233	PERMEase
IOD65_19025	COG2351	hydroxyisourate hydrolase activity
IOD65_19065	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IOD65_19105	COG0582	viral genome integration into host DNA
IOD65_19120	COG2130	NADP-dependent
IOD65_19125	COG1309	transcriptional regulator
IOD65_19135	COG1902	pentaerythritol trinitrate reductase activity
IOD65_19145	COG1979	alcohol dehydrogenase
IOD65_19160	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IOD65_19175	COG3321	synthase
IOD65_19175	COG0604	alcohol dehydrogenase
IOD65_19180	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IOD65_19185	COG0583	DNA-binding transcription factor activity
IOD65_19190	COG4221	oxidoreductase activity
IOD65_19225	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
IOD65_19260	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
IOD65_19455	COG0589	response to stress
IOD65_19485	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
IOD65_19515	COG0659	secondary active sulfate transmembrane transporter activity
IOD65_19520	COG0589	response to stress