locus-tag class description F2A31_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) F2A31_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F2A31_00025 ENOG4105DQR SNARE associated Golgi F2A31_00030 ENOG4105C5H ABC transporter F2A31_00035 ENOG4108821 RND type efflux pump F2A31_00040 ENOG4108821 RND type efflux pump F2A31_00045 ENOG4108821 RND type efflux pump F2A31_00055 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) F2A31_00060 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) F2A31_00115 ENOG4108XC3 NADH ubiquinone oxidoreductase F2A31_00125 ENOG4105C8J )-transporter F2A31_00135 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B F2A31_00165 ENOG4105C2W permease F2A31_00175 ENOG4105J7D transcriptional regulator F2A31_00180 ENOG4105DJY efflux transporter, rnd family, mfp subunit F2A31_00210 ENOG4105F27 Major Facilitator F2A31_00215 ENOG4105CV8 reductase F2A31_00220 ENOG4105HEI LysR family (Transcriptional regulator F2A31_00230 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F2A31_00235 ENOG4105DQ4 alcohol dehydrogenase F2A31_00240 ENOG4108R3E Dna-3-methyladenine glycosylase i F2A31_00255 ENOG4105CEN a g-specific adenine glycosylase F2A31_00270 ENOG4108ZZ3 UPF0260 protein F2A31_00285 ENOG4105D1H recombination factor protein RarA F2A31_00300 ENOG4105C8V SAICAR synthetase F2A31_00310 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F2A31_00315 ENOG4108RWI nicotinamidase F2A31_00330 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) F2A31_00340 ENOG4108ZAI phosphatidylglycerophosphatase a F2A31_00345 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) F2A31_00350 ENOG4107YIM Involved in the transcription termination process (By similarity) F2A31_00360 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) F2A31_00370 ENOG4105EAC phosphoserine phosphatase F2A31_00405 ENOG4105KHC sulfurtransferase F2A31_00415 ENOG4107TIF Phenazine biosynthesis protein, PhzF family F2A31_00420 ENOG4105VEQ Cold shock protein F2A31_00425 ENOG4105EJC lysr family transcriptional regulator F2A31_00435 ENOG4105BZU Histidine kinase F2A31_00440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F2A31_00455 ENOG4107QJQ Mate efflux family protein F2A31_00460 ENOG4105CHM Aminotransferase F2A31_00465 ENOG4106BRA Membrane F2A31_00480 ENOG4105D9M gamma-glutamylcysteine synthetase F2A31_00495 ENOG4105IPS esterase F2A31_00500 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F2A31_00505 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein F2A31_00510 ENOG4105C32 Amino acid ABC transporter (Permease) F2A31_00520 ENOG4105C0Z ABC transporter F2A31_00525 ENOG4108IV0 ABC, transporter F2A31_00535 ENOG4108Z7F N-acetyltransferase F2A31_00560 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) F2A31_00565 ENOG4107MKT Stringent starvation protein a F2A31_00570 ENOG4105BZ1 (ABC) transporter F2A31_00590 ENOG4105KUZ arsenate reductase F2A31_00595 ENOG4105CGK Exodeoxyribonuclease III F2A31_00605 ENOG4105CPF Cell wall formation (By similarity) F2A31_00630 ENOG4105CHR reductase F2A31_00645 ENOG4108V06 Glutathione peroxidase F2A31_00650 ENOG4105D7Z glutathione synthase F2A31_00670 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) F2A31_00675 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) F2A31_00680 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) F2A31_00700 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) F2A31_00705 ENOG4107QSN dihydrolipoamide acetyltransferase F2A31_00725 ENOG4105E0K tonB-dependent siderophore receptor F2A31_00740 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) F2A31_00755 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) F2A31_00780 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F2A31_00785 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase F2A31_00795 ENOG4105D64 Mechanosensitive ion channel F2A31_00800 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) F2A31_00805 ENOG4105FBW Monooxygenase F2A31_00810 ENOG4108UZX fmn reductase F2A31_00825 ENOG4108HWY Beta-lactamase F2A31_00830 ENOG4105BZU Histidine kinase F2A31_00840 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) F2A31_00855 ENOG4108IXY short-chain dehydrogenase reductase F2A31_00865 ENOG4105DWF phosphomethylpyrimidine kinase F2A31_00875 ENOG4107RDB Major Facilitator F2A31_00880 ENOG4108UUM single-stranded DNA-binding protein F2A31_00900 ENOG4108JPW Aminotransferase F2A31_00905 ENOG4105C26 Dehydrogenase F2A31_00915 ENOG4105CHJ isochorismatase hydrolase F2A31_00920 ENOG4105EUB pirin domain protein F2A31_00925 ENOG4105CVN desaturase F2A31_00940 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) F2A31_01005 ENOG4105CUV Homoserine Kinase F2A31_01030 ENOG4105CHH sulfate transporter F2A31_01050 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) F2A31_01085 ENOG4105CYC Transferase F2A31_01090 ENOG4105E0F Histidine kinase F2A31_01095 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F2A31_01135 ENOG4105CAN Short-chain dehydrogenase reductase Sdr F2A31_01140 ENOG4105CBN LysR family transcriptional regulator F2A31_01160 ENOG4105PDP Short chain dehydrogenase F2A31_01170 ENOG4105C5H ABC transporter F2A31_01245 ENOG4108IQI permease F2A31_01280 ENOG4105CJN penicillin-binding protein F2A31_01285 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) F2A31_01290 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) F2A31_01300 ENOG4105DHI Methyltransferase F2A31_01305 ENOG4108JQC penicillin-binding protein 1A F2A31_01330 ENOG4105E4G Type IV pilus F2A31_01350 ENOG4105CBC glutamate synthase F2A31_01355 ENOG4105BZ8 glutamate synthase F2A31_01365 ENOG4108V0P LemA family F2A31_01370 ENOG4105HA9 of methanol dehydrogenase type F2A31_01395 ENOG4108YSG O-Antigen polymerase F2A31_01400 ENOG4108UQY Iron-storage protein F2A31_01405 ENOG4105W53 bacterioferritin-associated ferredoxin F2A31_01410 ENOG4105KME endoribonuclease L-psp F2A31_01415 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) F2A31_01425 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) F2A31_01435 ENOG4108ZUW Major pilin subunit F2A31_01500 ENOG4105K5M 30s ribosomal protein S16 F2A31_01505 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) F2A31_01515 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) F2A31_01520 ENOG4107IFA Lipase (EC 3.1.1.3) F2A31_01525 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) F2A31_01530 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) F2A31_01550 ENOG4107AQZ Membrane F2A31_01555 ENOG4105E4C Lytic transglycosylase catalytic F2A31_01565 ENOG4108JQ1 Dehydrogenase F2A31_01570 ENOG4105CQB FAD linked oxidase domain protein F2A31_01595 ENOG4105VRH Antibiotic biosynthesis monooxygenase F2A31_01600 ENOG4105NF4 modulator of drug activity F2A31_01610 ENOG4107QF7 multi-drug F2A31_01615 ENOG4105EM2 membrane F2A31_01620 ENOG4105IPI Membrane F2A31_01625 ENOG4107SKI cobyrinic Acid a,c-diamide synthase F2A31_01635 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) F2A31_01670 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin F2A31_01680 ENOG4105F95 Monooxygenase F2A31_01725 ENOG4105C8P )-transporter F2A31_01735 ENOG41067S9 phage shock protein C, PspC F2A31_01745 ENOG4105CSU acyl-Coa dehydrogenase F2A31_01770 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) F2A31_01790 ENOG4105ECY inositol monophosphatase F2A31_01800 ENOG4105C1J atp-dependent rna helicase F2A31_01810 ENOG4105DHJ ABC, transporter F2A31_01815 ENOG4105CY3 ABC transporter, permease F2A31_01820 ENOG4107PE3 Mammalian cell entry related domain protein F2A31_01825 ENOG4105E3I toluene tolerance F2A31_01840 ENOG4105D7N magnesium and cobalt transport protein CorA F2A31_01845 ENOG4108URH decarboxylase F2A31_01855 ENOG4105MJ2 Competence protein F2A31_01860 ENOG4105CB5 ATP-dependent DNA helicase recG F2A31_01880 ENOG4105C29 acyl-CoA thioesterase F2A31_01885 ENOG4105CK2 sodium dicarboxylate symporter F2A31_01905 ENOG4105KPV Transcriptional regulator F2A31_01910 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F2A31_01915 ENOG4105D7A ATP-binding protein F2A31_01925 ENOG41089BK Glutamine amido-transferase F2A31_01935 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) F2A31_01955 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) F2A31_02035 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) F2A31_02040 ENOG41067V7 50S ribosomal protein L36 F2A31_02050 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) F2A31_02065 ENOG4108ZT0 50S ribosomal protein l17 F2A31_02085 ENOG4105C1G acyl-Coa dehydrogenase F2A31_02115 ENOG4105CG6 trap dicarboxylate transporter dctm subunit F2A31_02135 ENOG4105DGW oligopeptidase A F2A31_02140 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) F2A31_02215 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase F2A31_02235 ENOG4107S2Z UPF0761 membrane protein F2A31_02240 ENOG4105CS1 NAD(P)H quinone oxidoreductase F2A31_02265 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) F2A31_02290 ENOG4105DWV Homoserine O-trans-acetylase F2A31_02300 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) F2A31_02310 ENOG4105D05 Receptor F2A31_02320 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F2A31_02340 ENOG4107GFK fumarate F2A31_02345 ENOG4108MCI Transcriptional regulator, ARAC family F2A31_02350 ENOG4105DWP Membrane F2A31_02365 ENOG4108DNC Involved in acetate metabolism (By similarity) F2A31_02370 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) F2A31_02380 ENOG4106HB6 Alpha beta hydrolase F2A31_02395 ENOG4105CN1 protease F2A31_02415 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) F2A31_02425 ENOG4107RZC phospholipase d F2A31_02435 ENOG4105UYK outer membrane protein a F2A31_02440 ENOG4108KHX Diguanylate cyclase F2A31_02480 ENOG4105DSF transport protein F2A31_02485 ENOG4105C1G acyl-Coa dehydrogenase F2A31_02495 ENOG4105KNA -acetyltransferase F2A31_02505 ENOG4108RZE Tetr family transcriptional regulator F2A31_02525 ENOG4107QX3 carboxylase F2A31_02530 ENOG4105C1G acyl-Coa dehydrogenase F2A31_02555 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) F2A31_02585 ENOG4105KB2 stringent starvation protein b F2A31_02590 ENOG4107MKT Stringent starvation protein a F2A31_02600 ENOG4108UJD 30S ribosomal protein S9 F2A31_02605 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) F2A31_02615 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) F2A31_02620 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) F2A31_02625 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) F2A31_02640 ENOG4105WVQ Fe-S assembly protein IscX F2A31_02660 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) F2A31_02680 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) F2A31_02700 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) F2A31_02730 ENOG4105C84 Histidine ammonia-lyase F2A31_02750 ENOG4107T3I fad-binding protein F2A31_02760 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F2A31_02770 ENOG4105C2D reductase F2A31_02775 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F2A31_02790 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) F2A31_02795 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) F2A31_02800 ENOG4105VIE preprotein translocase, subunit YajC F2A31_02830 ENOG4105BZU Histidine kinase F2A31_02835 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) F2A31_02840 ENOG4105CM2 brancheD-chain amino acid aminotransferase F2A31_02845 ENOG4105C6Y Udp-glucose 6-dehydrogenase F2A31_02880 ENOG4105W1T Glycosyl Transferase F2A31_02905 ENOG4105C9M aspartyl-trna synthetase F2A31_02915 ENOG4105UGU tonB-dependent Receptor F2A31_02945 ENOG4108K3A Glutathione S-transferase F2A31_02950 ENOG4105EQ2 LysR family Transcriptional regulator F2A31_02955 ENOG4105CSU acyl-Coa dehydrogenase F2A31_02960 ENOG4105CSU acyl-Coa dehydrogenase F2A31_02970 ENOG4105EB3 Histidine kinase F2A31_02975 ENOG4105E3W Two component transcriptional regulator (Winged helix family F2A31_02985 ENOG4105CNG UPF0061 protein F2A31_03005 ENOG4108WBT adenosyltransferase F2A31_03020 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) F2A31_03025 ENOG4107T31 5'-nucleotidase F2A31_03035 ENOG4105CS6 Rhs element vgr protein F2A31_03085 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase F2A31_03100 ENOG4105D3R alkyl hydroperoxide reductase F2A31_03120 ENOG4105CSH Transporter F2A31_03125 ENOG4108UT2 hemolysin iii F2A31_03160 ENOG4105CHU acetyl-coa acetyltransferase F2A31_03170 ENOG4108R6W Transcriptional regulator, ARAC family F2A31_03175 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F F2A31_03180 ENOG4105TW1 Carbohydrate-selective porin OprB F2A31_03185 ENOG4105DZG Dehydrogenase F2A31_03210 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) F2A31_03225 ENOG4105CHU acetyl-coa acetyltransferase F2A31_03235 ENOG4108WHA ompa motb domain protein F2A31_03240 ENOG4108WHA ompa motb domain protein F2A31_03245 ENOG4105E0Y RtcB Protein F2A31_03250 ENOG4108IQI permease F2A31_03260 ENOG4105C2W permease F2A31_03275 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) F2A31_03285 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) F2A31_03295 ENOG4105CHB tonB-dependent Receptor F2A31_03315 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) F2A31_03325 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA F2A31_03330 ENOG4105KWI UPF0339 protein F2A31_03345 ENOG4108UNF response regulator F2A31_03350 ENOG4105M3Z response regulator F2A31_03355 ENOG4108ZGA chew protein F2A31_03360 ENOG4105C8Q Methyl-accepting chemotaxis F2A31_03365 ENOG4105CBS Chea signal transduction histidine kinase F2A31_03365 ENOG4105CBS Chea signal transduction histidine kinase F2A31_03380 ENOG4106HKS Entericidin EcnA/B family F2A31_03390 ENOG4105WD1 Membrane F2A31_03395 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein F2A31_03440 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) F2A31_03450 ENOG4105EM2 membrane F2A31_03455 ENOG4105C2C drug resistance transporter, Bcr CflA F2A31_03470 ENOG4105D6U Sodium Glutamate Symporter F2A31_03475 ENOG4105BZG amino acid carrier protein F2A31_03480 ENOG4105D78 K07001 NTE family protein F2A31_03530 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) F2A31_03540 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) F2A31_03545 ENOG4105DFF Rod shape-determining protein mreb F2A31_03550 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) F2A31_03560 ENOG4108Z03 MAF-like protein F2A31_03565 ENOG4105C03 ribonuclease F2A31_03575 ENOG4105D8T Acyltransferase F2A31_03585 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein F2A31_03600 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) F2A31_03605 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) F2A31_03610 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) F2A31_03615 ENOG4105C08 Histidine kinase F2A31_03620 ENOG4105EEX Two component transcriptional regulator (Winged helix family F2A31_03625 ENOG4107RGH Aldehyde dehydrogenase F2A31_03630 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase F2A31_03640 ENOG4105D05 Receptor F2A31_03655 ENOG4105E3J oxidoreductase F2A31_03670 ENOG4105E6M Sulphatase-modifying factor protein F2A31_03675 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) F2A31_03680 ENOG4105D2S major facilitator superfamily F2A31_03695 ENOG4105C85 amino acid F2A31_03700 ENOG4105C7F AcnD-accessory protein PrpF F2A31_03705 ENOG4105CTB Polyprenyl synthetase F2A31_03720 ENOG4105D78 K07001 NTE family protein F2A31_03740 ENOG4105DIJ Phosphoethanolamine transferase F2A31_03745 ENOG4105XJC Two component transcriptional regulator (Winged helix family F2A31_03750 ENOG4105DHQ Histidine kinase F2A31_03760 ENOG4105CDA abc transporter atp-binding protein F2A31_03765 ENOG4105DRP amino acid AbC transporter F2A31_03770 ENOG4105EAD ABC transporter F2A31_03775 ENOG4107RP9 extracellular solute-binding protein, family 3 F2A31_03795 ENOG4105WDY DNA (cytosine-5-)-methyltransferase F2A31_03810 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) F2A31_03835 ENOG4105K8R UPF0145 protein F2A31_03840 ENOG4105K8R UPF0145 protein F2A31_03845 ENOG4105ENJ RND efflux system, outer membrane lipoprotein F2A31_03850 ENOG4105BZS acriflavin resistance protein F2A31_03855 ENOG4105C1P efflux transporter, rnd family, mfp subunit F2A31_03860 ENOG410841Q phosphoesterase PA-phosphatase related protein F2A31_03885 ENOG4105EUB pirin domain protein F2A31_03890 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) F2A31_03905 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) F2A31_03910 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) F2A31_03920 ENOG4105KVH Transcriptional regulator F2A31_03935 ENOG4105CUB amino acid F2A31_03940 ENOG4105C0A alcohol dehydrogenase F2A31_03950 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) F2A31_03960 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F2A31_03980 ENOG4108MGI Transcriptional regulator F2A31_03985 ENOG4105FQ6 thiopurine methyltransferase F2A31_04005 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit F2A31_04010 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein F2A31_04020 ENOG4105E33 succinate dehydrogenase F2A31_04025 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 F2A31_04030 ENOG4105C7S Dehydrogenase F2A31_04035 ENOG4107QN2 dihydrolipoyl dehydrogenase F2A31_04045 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha F2A31_04050 ENOG4107S78 Band 7 protein F2A31_04055 ENOG4105PV3 Inner membrane protein yqiJ F2A31_04065 ENOG4105CKW Inner membrane protein yedI F2A31_04070 ENOG4105CGZ zinc metallopeptidase F2A31_04075 ENOG4105EEQ Na H antiporter F2A31_04105 ENOG4108I69 Glycosyl transferases group 1 F2A31_04145 ENOG4105EQK -acetyltransferase F2A31_04160 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain F2A31_04165 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain F2A31_04180 ENOG4105HBR Rna-binding protein F2A31_04190 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) F2A31_04205 ENOG4105CP2 von willebrand factor, type a F2A31_04215 ENOG4107U2T alpha beta F2A31_04225 ENOG4107XDY Nicotinamide Mononucleotide Transporter F2A31_04230 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase F2A31_04235 ENOG4105DIJ Phosphoethanolamine transferase F2A31_04240 ENOG4105BZS acriflavin resistance protein F2A31_04245 ENOG4105CJW magnesium transporter F2A31_04255 ENOG4105D0M Protease HtpX homolog F2A31_04260 ENOG4105E4C Lytic transglycosylase catalytic F2A31_04265 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) F2A31_04275 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) F2A31_04280 ENOG4108RRZ Transcription elongation factor GreB F2A31_04290 ENOG4105CK2 sodium dicarboxylate symporter F2A31_04295 ENOG4107YNJ LysR family Transcriptional regulator F2A31_04300 ENOG4108IJ0 Aspartate ammonia-lyase F2A31_04330 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F2A31_04410 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein F2A31_04415 ENOG4105E0C molybdate abc transporter F2A31_04420 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) F2A31_04430 ENOG4105PGM cation diffusion facilitator family transporter F2A31_04445 ENOG4106FTQ Taurine ABC transporter, periplasmic F2A31_04450 ENOG4108IY8 ABC, transporter F2A31_04455 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component F2A31_04460 ENOG4105E2B Taurine dioxygenase F2A31_04475 ENOG4107R72 Ceramidase F2A31_04490 ENOG4107YZX Universal stress protein F2A31_04505 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) F2A31_04510 ENOG4105WDY DNA (cytosine-5-)-methyltransferase F2A31_04525 ENOG4105C3R Methionine synthase F2A31_04535 ENOG4105CJ3 phosphate transporter F2A31_04545 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) F2A31_04550 ENOG4105BZG amino acid carrier protein F2A31_04560 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) F2A31_04565 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) F2A31_04575 ENOG4105N14 lysine exporter protein LysE YggA F2A31_04580 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F2A31_04585 ENOG4105BZJ Electron transfer flavoprotein F2A31_04590 ENOG4105C10 Electron transfer flavoprotein F2A31_04600 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) F2A31_04615 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F2A31_04630 ENOG4107KET secretion protein, HlyD family F2A31_04650 ENOG4108UPT UPF0178 protein F2A31_04665 ENOG4105D60 lipoprotein releasing system transmembrane protein F2A31_04670 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) F2A31_04675 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 F2A31_04685 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) F2A31_04695 ENOG4108V3E phosphoribosylglycinamide formyltransferase F2A31_04705 ENOG4105C02 permease F2A31_04710 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) F2A31_04760 ENOG4105KCK Peptidoglycan-associated lipoprotein F2A31_04765 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) F2A31_04775 ENOG4105M8F Biopolymer transport protein exbD tolR F2A31_04780 ENOG4105E02 MotA TolQ exbB proton channel F2A31_04785 ENOG4107YD3 Thioesterase F2A31_04790 ENOG4105CH2 amidohydrolase F2A31_04795 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) F2A31_04810 ENOG4108ETH Formylglycinamide ribotide synthetase F2A31_04825 ENOG4105EGD dinuclear metal center protein, YbgI family F2A31_04835 ENOG4105DM4 PTS System F2A31_04845 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) F2A31_04850 ENOG41060WC Enoyl-CoA hydratase F2A31_04860 ENOG4105EGI Transcriptional regulator F2A31_04865 ENOG4105VSH 4-oxalocrotonate tautomerase F2A31_04885 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F2A31_04900 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) F2A31_04905 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) F2A31_04920 ENOG4107R11 Transcriptional regulator F2A31_04925 ENOG4108IJ6 ABC transporter F2A31_04935 ENOG4108I5D sulfate abc transporter F2A31_04945 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein F2A31_04950 ENOG4105YAZ 4-amino-4-deoxychorismate lyase F2A31_04955 ENOG4105HHA aminodeoxychorismate lyase F2A31_04965 ENOG4108IYU L-aspartate oxidase F2A31_04970 ENOG4105C0H protease F2A31_04980 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) F2A31_04985 ENOG4105C3F Signal peptidase i F2A31_04995 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) F2A31_05000 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) F2A31_05010 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) F2A31_05015 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) F2A31_05020 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase F2A31_05070 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) F2A31_05075 ENOG4105QNF Outer membrane lipoprotein F2A31_05115 ENOG4107QKW extracellular solute-binding protein family 1 F2A31_05120 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F2A31_05130 ENOG4107QS8 (LipO)protein F2A31_05135 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) F2A31_05140 ENOG4105C5Q Transcriptional regulator F2A31_05145 ENOG4108WC5 Alpha Beta Hydrolase Fold protein F2A31_05150 ENOG4107QZF nitrite reductase NADPH large subunit F2A31_05155 ENOG4105VCQ rubredoxin F2A31_05165 ENOG4105CRK lysyL-tRNA synthetase F2A31_05170 ENOG4108MRJ F2A31_05175 ENOG4105C11 sulfate adenylyltransferase), subunit 2 F2A31_05180 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) F2A31_05190 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) F2A31_05195 ENOG4105C37 (CBS) domain F2A31_05205 ENOG4107RET Isocitrate lyase F2A31_05210 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion F2A31_05225 ENOG4105C2X Arabinose 5-phosphate isomerase F2A31_05230 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase F2A31_05240 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA F2A31_05245 ENOG4108IUZ ABC transporter F2A31_05250 ENOG4105DFG type I secretion outer membrane protein F2A31_05290 ENOG4108Z4U Ferredoxin F2A31_05320 ENOG4106P55 Transcriptional regulator F2A31_05350 ENOG4105KT5 UmuD protein F2A31_05385 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase F2A31_05390 ENOG4105ERG peptidase m48, ste24p F2A31_05405 ENOG4105KTH gatB Yqey F2A31_05410 ENOG4105VCC 30S ribosomal protein S21 F2A31_05435 ENOG4108UZ3 Transporter F2A31_05470 ENOG4105D9P serine threonine protein kinase F2A31_05495 ENOG4105CS6 Rhs element vgr protein F2A31_05510 ENOG4105E6M Sulphatase-modifying factor protein F2A31_05555 ENOG4105CND Glycosyl transferase, family 2 F2A31_05565 ENOG4107BJW polysaccharide deacetylase F2A31_05570 ENOG41069M3 Transcriptional regulator F2A31_05590 ENOG4107EXU Short-chain dehydrogenase reductase Sdr F2A31_05600 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase F2A31_05605 ENOG4105DJB Major Facilitator Superfamily F2A31_05620 ENOG4105CHR reductase F2A31_05635 ENOG4105C7K acetolactate synthase F2A31_05645 ENOG4107QTF adenylosuccinate lyase F2A31_05655 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) F2A31_05670 ENOG4108Z0R Transferase F2A31_05675 ENOG4105DZ1 carboxypeptidase F2A31_05695 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) F2A31_05700 ENOG4108K5P (LipO)protein F2A31_05705 ENOG4105EJC lysr family transcriptional regulator F2A31_05710 ENOG4105DAN ATP-dependent protease F2A31_05725 ENOG4105DHU Bile acid F2A31_05730 ENOG4105VFB Binds the 23S rRNA (By similarity) F2A31_05745 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein F2A31_05750 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) F2A31_05755 ENOG4105D22 carbon starvation protein F2A31_05760 ENOG4105VCD cytoplasmic protein F2A31_05765 ENOG4105C7R Atpase associated with various cellular activities aaa_3 F2A31_05775 ENOG4105F8C transglutaminase domain-containing protein F2A31_05835 ENOG4105M03 Domain of unknown function (DUF955) F2A31_05865 ENOG4105C2I pirin domain protein F2A31_05880 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F2A31_05890 ENOG4108ZX5 transcriptional regulator F2A31_05895 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr F2A31_05900 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) F2A31_05910 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F2A31_05935 ENOG4105CR8 Transcriptional regulator F2A31_05940 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F2A31_05970 ENOG4105CS6 Rhs element vgr protein F2A31_05975 ENOG4105CNA YD repeat protein F2A31_06000 ENOG4105CD3 dihydroorotase F2A31_06010 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase F2A31_06015 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) F2A31_06030 ENOG4105CKI cobalamin synthesis protein F2A31_06035 ENOG4107HP6 Transcriptional regulator F2A31_06040 ENOG4107QP7 CoA-transferase subunit A F2A31_06045 ENOG4107QNJ CoA-transferase subunit B F2A31_06050 ENOG4105CHU acetyl-coa acetyltransferase F2A31_06055 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase F2A31_06060 ENOG4105F2Z 3-oxoadipate enol-lactonase F2A31_06065 ENOG4105D2S major facilitator superfamily F2A31_06070 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase F2A31_06075 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta F2A31_06080 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha F2A31_06085 ENOG4105FF2 Type I DHQase F2A31_06090 ENOG4106JPM 3-dehydroshikimate dehydratase F2A31_06095 ENOG4105TW1 Carbohydrate-selective porin OprB F2A31_06100 ENOG4105DZG Dehydrogenase F2A31_06110 ENOG4105VT2 5-hydroxyisourate hydrolase F2A31_06115 ENOG4105C2W permease F2A31_06125 ENOG41061H0 Monooxygenase F2A31_06130 ENOG41073TP transcriptional regulator F2A31_06135 ENOG4105DHG Allantoate amidinohydrolase F2A31_06150 ENOG4107Z6I Thiamine biosynthesis protein F2A31_06160 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component F2A31_06175 ENOG4105SKE transcriptional Regulator LysR family F2A31_06185 ENOG4105CZE histidine utilization repressor F2A31_06205 ENOG41088SP formiminoglutamate hydrolase F2A31_06210 ENOG4105D82 Glutamate dehydrogenase F2A31_06215 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F2A31_06225 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit F2A31_06230 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) F2A31_06235 ENOG4105EZR dyp-type peroxidase family protein F2A31_06245 ENOG4105ENJ RND efflux system, outer membrane lipoprotein F2A31_06250 ENOG4105BZS acriflavin resistance protein F2A31_06255 ENOG4105C1P efflux transporter, rnd family, mfp subunit F2A31_06260 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F2A31_06265 ENOG4105GR3 Histidine kinase F2A31_06270 ENOG4105QNF Outer membrane lipoprotein F2A31_06290 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase F2A31_06300 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase F2A31_06305 ENOG4105DHQ Histidine kinase F2A31_06345 ENOG4105F95 Monooxygenase F2A31_06350 ENOG4105JQZ Methyltransferase F2A31_06355 ENOG4105D1S lipid A biosynthesis F2A31_06360 ENOG4105E7W lamb ycsf family protein F2A31_06365 ENOG4105P4J Allophanate hydrolase, subunit 1 F2A31_06370 ENOG4108JIK carboxylase F2A31_06375 ENOG4108K0D peptidase, M48 F2A31_06380 ENOG4107RYR Transcriptional regulator, Crp Fnr family F2A31_06385 ENOG4108UKZ OsmC family F2A31_06395 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F2A31_06420 ENOG4105CD3 dihydroorotase F2A31_06435 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) F2A31_06465 ENOG4105CD8 aminopeptidase N F2A31_06470 ENOG4105EJQ L-serine dehydratase F2A31_06480 ENOG41085PJ rdd domain containing protein F2A31_06490 ENOG4105CKD glutathione-regulated potassium-efflux system protein F2A31_06495 ENOG4105DKK Benzoate F2A31_06500 ENOG4108NIW Leucine export protein LeuE F2A31_06505 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F2A31_06510 ENOG4105HEI LysR family (Transcriptional regulator F2A31_06525 ENOG4108JA2 transcriptioN-repair coupling factor F2A31_06535 ENOG4105F8J Adenylate Guanylate cyclase F2A31_06540 ENOG4108ZIT Ferredoxin, 2FE-2S F2A31_06555 ENOG4108Z4V iron-sulfur cluster assembly F2A31_06560 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins F2A31_06570 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family F2A31_06585 ENOG4105K70 DNA-binding protein F2A31_06590 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) F2A31_06605 ENOG4105Y3E Modulates RecA activity (By similarity) F2A31_06615 ENOG4105VEJ Heat shock protein F2A31_06620 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 F2A31_06625 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase F2A31_06645 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) F2A31_06650 ENOG4105K4T epimerase F2A31_06655 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) F2A31_06675 ENOG4105CHR reductase F2A31_06700 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) F2A31_06710 ENOG4108UHJ MAF-like protein F2A31_06735 ENOG41069NU Nitroreductase F2A31_06770 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase F2A31_06810 ENOG4108JU3 Alkyl hydroperoxide reductase F2A31_06835 ENOG4105C0B DNA polymerase III (alpha subunit) F2A31_06845 ENOG4105CHM Aminotransferase F2A31_06850 ENOG4105E0X reductase F2A31_06855 ENOG4108V06 Glutathione peroxidase F2A31_06865 ENOG4105ENT Efflux transporter rnd family, mfp subunit F2A31_06870 ENOG4105F7P transcriptional regulator AsnC family F2A31_06880 ENOG4105CHM Aminotransferase F2A31_06910 ENOG4105IJJ transcriptional regulator, crp fnr family F2A31_06920 ENOG4105C3G gtp-binding protein F2A31_06925 ENOG4108UMI ABC transporter, permease F2A31_06930 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) F2A31_06935 ENOG4105D01 (LipO)protein F2A31_06950 ENOG4107T8P acyl-Coa dehydrogenase F2A31_06965 ENOG4105CIN aminoacyl-histidine dipeptidase F2A31_06985 ENOG4105E0Y RtcB Protein F2A31_06990 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) F2A31_06995 ENOG4105CYB regulatoR F2A31_07035 ENOG4105M08 Membrane F2A31_07040 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F2A31_07050 ENOG4105VEQ Cold shock protein F2A31_07055 ENOG4105C1J atp-dependent rna helicase F2A31_07060 ENOG4105D2N Aldolase F2A31_07065 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) F2A31_07070 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) F2A31_07075 ENOG4105EHM Aminoglycoside phosphotransferase F2A31_07080 ENOG4108S0S Nucleotidyl transferase F2A31_07090 ENOG4107QJE Chromosome Partitioning Protein F2A31_07095 ENOG4105FA0 parb-like partition protein F2A31_07110 ENOG4105BZ1 (ABC) transporter F2A31_07115 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) F2A31_07125 ENOG4107QRG dna polymerase iii F2A31_07140 ENOG4105F8V Hydrolase, tatD family F2A31_07165 ENOG4108RTD type II secretion system protein K F2A31_07185 ENOG4108Z6B deaminase F2A31_07200 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) F2A31_07205 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) F2A31_07220 ENOG4105DWU Membrane F2A31_07225 ENOG4107RN6 Monooxygenase F2A31_07235 ENOG4105D6Z AFG1 family ATPase F2A31_07240 ENOG4107QP3 malate synthase g F2A31_07275 ENOG4105CWM branched-chain amino acid transport system II carrier protein F2A31_07280 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) F2A31_07285 ENOG4105CC0 LysR family Transcriptional regulator F2A31_07295 ENOG4105M2J Glutaredoxin F2A31_07300 ENOG4105C8Y Acetylornithine aminotransferase F2A31_07305 ENOG4105C2X Arabinose 5-phosphate isomerase F2A31_07330 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) F2A31_07360 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F2A31_07365 ENOG4105C4M (Ubiquinol oxidase) subunit I F2A31_07395 ENOG4105HDD phospholipase F2A31_07405 ENOG4105CZN Potassium uptake protein F2A31_07415 ENOG4105C7B Threonine dehydratase F2A31_07420 ENOG4105E66 phosphoriboisomerase A F2A31_07435 ENOG4105G6Z alkaline phosphatase F2A31_07455 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) F2A31_07460 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) F2A31_07465 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F2A31_07475 ENOG4105C5H ABC transporter F2A31_07480 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) F2A31_07485 ENOG4108MXF Alpha Beta Hydrolase F2A31_07495 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F2A31_07530 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) F2A31_07535 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) F2A31_07595 ENOG4107RZC phospholipase d F2A31_07620 ENOG4105DRR Transcriptional regulator, GntR family F2A31_07630 ENOG4105CF7 AraC family transcriptional regulator F2A31_07635 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) F2A31_07680 ENOG4105DDY UPF0142 protein ycaO F2A31_07700 ENOG4108YXU transcriptional regulator AsnC family F2A31_07715 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase F2A31_07720 ENOG4105MRR Transcriptional regulator (By similarity) F2A31_07725 ENOG4105GVF (ABC) transporter F2A31_07735 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component F2A31_07760 ENOG4105C1G acyl-Coa dehydrogenase F2A31_07765 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F F2A31_07775 ENOG4108UKI Enoyl-CoA hydratase F2A31_07780 ENOG4105EA8 2-Nitropropane dioxygenase F2A31_07790 ENOG4105CHU acetyl-coa acetyltransferase F2A31_07795 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase F2A31_07800 ENOG4105E39 Enoyl-CoA hydratase F2A31_07805 ENOG4105C1G acyl-Coa dehydrogenase F2A31_07810 ENOG4107RGD Major Facilitator superfamily F2A31_07815 ENOG4107QP7 CoA-transferase subunit A F2A31_07820 ENOG4107QNJ CoA-transferase subunit B F2A31_07830 ENOG4105EQ0 Major Facilitator superfamily F2A31_07840 ENOG4105CSU acyl-Coa dehydrogenase F2A31_07845 ENOG4105MP9 class II Aldolase F2A31_07860 ENOG4105CR8 Transcriptional regulator F2A31_07875 ENOG4105E39 Enoyl-CoA hydratase F2A31_07880 ENOG4107QX3 carboxylase F2A31_07885 ENOG4105C1G acyl-Coa dehydrogenase F2A31_07890 ENOG4105R8C Transcriptional regulator F2A31_07895 ENOG4105CEY Amp-dependent synthetase and ligase F2A31_07910 ENOG4105D2S major facilitator superfamily F2A31_07915 ENOG41061TZ Short-chain dehydrogenase reductase Sdr F2A31_07920 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr F2A31_07930 ENOG4105CSU acyl-Coa dehydrogenase F2A31_07935 ENOG4105CHU acetyl-coa acetyltransferase F2A31_07950 ENOG4105F04 LysR family Transcriptional regulator F2A31_07960 ENOG4105E0K tonB-dependent siderophore receptor F2A31_07990 ENOG4105D5K Hemolysin activator protein F2A31_07995 ENOG4105CKT filamentous hemagglutinin F2A31_08110 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria F2A31_08120 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) F2A31_08130 ENOG4105GR3 Histidine kinase F2A31_08170 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) F2A31_08180 ENOG4105C28 cystathionine F2A31_08210 ENOG4105K59 histidine triad (HIT) protein F2A31_08240 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) F2A31_08260 ENOG4107TSN permease F2A31_08265 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) F2A31_08275 ENOG4105D05 Receptor F2A31_08290 ENOG4105CVJ phosphoglycerate mutase F2A31_08295 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) F2A31_08300 ENOG4108YZT Adenosylcobinamide kinase F2A31_08310 ENOG4107VXZ Hydrolase F2A31_08340 ENOG4105JSC dimethylmenaquinone methyltransferase F2A31_08350 ENOG4105DJU Siderophore biosynthesis protein F2A31_08355 ENOG4105DUU IucA IucC family protein F2A31_08360 ENOG4105C0R drug resistance transporter emrb qaca subfamily F2A31_08375 ENOG4108Z66 YbaK ebsC protein F2A31_08390 ENOG4105C1G acyl-Coa dehydrogenase F2A31_08395 ENOG4105C1G acyl-Coa dehydrogenase F2A31_08410 ENOG4105DC8 reductase F2A31_08415 ENOG4105EEF Alkane 1-monooxygenase F2A31_08420 ENOG4105E7U AraC family transcriptional regulator F2A31_08425 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) F2A31_08435 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) F2A31_08445 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane F2A31_08450 ENOG4105DZP Membrane-associated zinc metalloprotease F2A31_08460 ENOG4105KNE Phosphatidate cytidylyltransferase F2A31_08465 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) F2A31_08470 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) F2A31_08475 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) F2A31_08485 ENOG4105CUX Signal transduction histidine kinase F2A31_08490 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F2A31_08495 ENOG4105M4P Tetr family transcriptional regulator F2A31_08540 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) F2A31_08560 ENOG4105T38 integral membrane protein F2A31_08575 ENOG4105CVM Molybdenum cofactor synthesis domain protein F2A31_08580 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) F2A31_08605 ENOG4105BZC d-serine deaminase F2A31_08620 ENOG4108IFG nitrite reductase, (NAD(P)H) F2A31_08625 ENOG4107QZF nitrite reductase NADPH large subunit F2A31_08630 ENOG4107RNU major facilitator superfamily MFS_1 F2A31_08650 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein F2A31_08655 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase F2A31_08680 ENOG4105CBC glutamate synthase F2A31_08705 ENOG4105C0A alcohol dehydrogenase F2A31_08715 ENOG4107QMP dna polymerase iii subunits gamma and tau F2A31_08720 ENOG4105EZE Cupin 4 family protein F2A31_08740 ENOG41080HT Transcriptional regulator, arsr family F2A31_08760 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme F2A31_08765 ENOG4105CUY Mechanosensitive ion channel F2A31_08775 ENOG4105BZ1 (ABC) transporter F2A31_08785 ENOG4108ZX5 transcriptional regulator F2A31_08795 ENOG4105CK7 Sodium proline symporter F2A31_08800 ENOG4105EW9 transcriptional regulator AsnC family F2A31_08805 ENOG4105C26 Dehydrogenase F2A31_08810 ENOG4105YGK Pfam:UPF0157 F2A31_08815 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) F2A31_08825 ENOG4108T58 Mg2 transport protein CorA F2A31_08840 ENOG4108YYD acetyltransferase F2A31_08845 ENOG4108YYC ycei family F2A31_08870 ENOG4105CV1 Transketolase (EC 2.2.1.1) F2A31_08875 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP F2A31_08890 ENOG4105UCG Domain of unknown function (DUF333) F2A31_08895 ENOG4105VEQ Cold shock protein F2A31_08900 ENOG4105VEQ Cold shock protein F2A31_08920 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) F2A31_08925 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) F2A31_08945 ENOG4105X0I Fimbrial F2A31_08995 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase F2A31_09000 ENOG4105CQC Prephenate dehydratase F2A31_09015 ENOG4105C1G acyl-Coa dehydrogenase F2A31_09020 ENOG4107QYG anthranilate phosphoribosyltransferase F2A31_09040 ENOG4105CS6 Rhs element vgr protein F2A31_09045 ENOG4105VUT cytoplasmic protein F2A31_09050 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) F2A31_09055 ENOG4105BZ4 penicillin-binding protein F2A31_09065 ENOG4105M6F mutator MutT protein F2A31_09075 ENOG4107QHF type ii secretion system protein e F2A31_09080 ENOG4108R96 Methyltransferase, YaeB family F2A31_09085 ENOG4105DP0 ferredoxin-NADP reductase F2A31_09090 ENOG41082JN Transcriptional regulator F2A31_09115 ENOG4105DZ2 Transcriptional regulator F2A31_09120 ENOG4105WPN DNA integration recombination invertion protein F2A31_09130 ENOG4105CZN Potassium uptake protein F2A31_09140 ENOG4105F27 Major Facilitator F2A31_09150 ENOG4108IPW abc transporter atp-binding protein F2A31_09155 ENOG4105CM4 permease protein F2A31_09160 ENOG4105DHS permease protein F2A31_09170 ENOG4105EYW Ion transport protein F2A31_09185 ENOG4107QIJ Aconitate hydratase 2 F2A31_09200 ENOG4105CFU surface antigen F2A31_09205 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) F2A31_09225 ENOG4105KRF dihydroneopterin aldolase F2A31_09235 ENOG4105D06 uba thif-type nad fad binding protein F2A31_09260 ENOG4107IFA Lipase (EC 3.1.1.3) F2A31_09270 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F2A31_09280 ENOG4108R6W Transcriptional regulator, ARAC family F2A31_09290 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) F2A31_09330 ENOG4105DA5 (ABC) transporter F2A31_09335 ENOG4105E3A (ABC) transporter F2A31_09350 ENOG4105CNI cell division protein FtsW F2A31_09355 ENOG4105CVE Lytic murein transglycosylase F2A31_09375 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) F2A31_09380 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) F2A31_09395 ENOG4105CQ7 ATP-dependent helicase F2A31_09405 ENOG4105D3R alkyl hydroperoxide reductase F2A31_09415 ENOG4105EEF Alkane 1-monooxygenase F2A31_09435 ENOG4108JU3 Alkyl hydroperoxide reductase F2A31_09445 ENOG4108K3A Glutathione S-transferase F2A31_09455 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) F2A31_09470 ENOG4107QUV Domain protein F2A31_09480 ENOG4105CUB amino acid F2A31_09485 ENOG4105CPD ethanolamine ammonia-lyase F2A31_09490 ENOG4107FQ9 ethanolamine ammonia-lyase F2A31_09495 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) F2A31_09500 ENOG4105CX6 glutaminyL-tRNA synthetase F2A31_09510 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) F2A31_09515 ENOG4108RCM Nitroreductase F2A31_09520 ENOG4105DYS nad(p)h dehydrogenase (quinone) F2A31_09530 ENOG4108TZV Membrane F2A31_09535 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) F2A31_09545 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) F2A31_09550 ENOG4105K8N protein family UPF0079, ATPase F2A31_09570 ENOG4105I08 Pseudouridine synthase F2A31_09580 ENOG4105DEN Luciferase family F2A31_09585 ENOG4105BZU Histidine kinase F2A31_09605 ENOG4105E2S oxidase) subunit II F2A31_09610 ENOG4105BZ9 Cytochrome C oxidase, subunit I F2A31_09615 ENOG4105CCU oxidase (Subunit III) F2A31_09620 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) F2A31_09645 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein F2A31_09650 ENOG4105KVH Transcriptional regulator F2A31_09655 ENOG4105CDU Replicative dna helicase F2A31_09660 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) F2A31_09695 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis F2A31_09715 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase F2A31_09725 ENOG4105CFH Aspartokinase F2A31_09735 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) F2A31_09745 ENOG4105CPW cytochrome b561 F2A31_09750 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) F2A31_09755 ENOG4105C7N Xanthine uracil vitamin C permease F2A31_09775 ENOG4108R6W Transcriptional regulator, ARAC family F2A31_09810 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) F2A31_09815 ENOG4105DC1 bifunctional purine biosynthesis protein purh F2A31_09820 ENOG4105C12 Phosphoribosylglycinamide synthetase F2A31_09830 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) F2A31_09835 ENOG4108UMI ABC transporter, permease F2A31_09860 ENOG4105CEY Amp-dependent synthetase and ligase F2A31_09865 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) F2A31_09870 ENOG4105SYT Methylenetetrahydrofolate reductase F2A31_09875 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) F2A31_09880 ENOG4105BZU Histidine kinase F2A31_09885 ENOG4105C6K Malic enzyme F2A31_09905 ENOG4105CE9 30S ribosomal protein S2 F2A31_09910 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) F2A31_09920 ENOG4107RNU major facilitator superfamily MFS_1 F2A31_09930 ENOG4105C0H protease F2A31_09935 ENOG4107QNR UPF0135 protein F2A31_09940 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F2A31_09975 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) F2A31_09985 ENOG4105C5F glutamine synthetase F2A31_10000 ENOG4105DDQ anthranilate synthase F2A31_10005 ENOG4108ETY sodium dicarboxylate symporter F2A31_10010 ENOG4105QVC MOSC domain-containing protein F2A31_10030 ENOG4105EUJ GTP cyclohydrolase i F2A31_10050 ENOG4105NX3 Membrane F2A31_10075 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) F2A31_10090 ENOG4108JQ5 ABC transporter F2A31_10095 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component F2A31_10100 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component F2A31_10105 ENOG4105E43 Extracellular solute-binding protein, family 5 F2A31_10110 ENOG4105E9H Lytic Murein transglycosylase F2A31_10110 ENOG4105E9H Lytic Murein transglycosylase F2A31_10115 ENOG4108JDX DNA polymerase iii, epsilon subunit F2A31_10125 ENOG4105E09 nadh pyrophosphatase F2A31_10135 ENOG4105W4M Transport-associated protein F2A31_10150 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) F2A31_10155 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) F2A31_10160 ENOG4108ZUB Lysine exporter protein (Lyse ygga) F2A31_10180 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family F2A31_10185 ENOG4105D0A hydroxylase F2A31_10190 ENOG4107RAQ aminopeptidase F2A31_10215 ENOG4108821 RND type efflux pump F2A31_10220 ENOG4105C59 p-type ATPase F2A31_10240 ENOG4105DEG Vwa containing coxe family protein F2A31_10250 ENOG4105KKX ATPase associated with various cellular activities aaa_5 F2A31_10255 ENOG4108KDT Molybdate metabolism regulator F2A31_10270 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase F2A31_10285 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b F2A31_10330 ENOG4108R3D Electron transport complex F2A31_10335 ENOG4105CSM endonuclease III F2A31_10360 ENOG4105CJN penicillin-binding protein F2A31_10365 ENOG4106H78 methyltransferase F2A31_10390 ENOG4105ERU peptidase F2A31_10395 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) F2A31_10405 ENOG4105C8U phosphate abc transporter F2A31_10420 ENOG4105DY8 decarboxylase F2A31_10425 ENOG4108JPW Aminotransferase F2A31_10435 ENOG4105GAV receptor F2A31_10445 ENOG4105MKU Transcriptional regulator F2A31_10460 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F2A31_10495 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) F2A31_10500 ENOG4105D3G Pseudouridine synthase F2A31_10515 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) F2A31_10575 ENOG4107TIF Phenazine biosynthesis protein, PhzF family F2A31_10585 ENOG4108R99 pseudouridine synthase F2A31_10590 ENOG4105E9K Isocitrate dehydrogenase F2A31_10595 ENOG4105VT2 5-hydroxyisourate hydrolase F2A31_10605 ENOG4105DZ1 carboxypeptidase F2A31_10610 ENOG4105CEP NADH dehydrogenase F2A31_10615 ENOG4108YZY peptidylprolyl cis-trans isomerase F2A31_10620 ENOG4105CVP deoxyribo-dipyrimidine photolyase F2A31_10635 ENOG4107R8N Glycosyl transferase, family 2 F2A31_10660 ENOG4105C4M (Ubiquinol oxidase) subunit I F2A31_10665 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F2A31_10685 ENOG4107U91 Rhomboid family F2A31_10695 ENOG4105CV6 ABC transporter, permease F2A31_10700 ENOG4108I0Y (ABC) transporter F2A31_10705 ENOG4108UJV acyl-CoA thioesterase i F2A31_10730 ENOG4105D05 Receptor F2A31_10745 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) F2A31_10755 ENOG41080IJ Diacylglycerol kinase F2A31_10770 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) F2A31_10775 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) F2A31_10780 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) F2A31_10790 ENOG4105CKT filamentous hemagglutinin F2A31_10795 ENOG4105D5K Hemolysin activator protein F2A31_10805 ENOG4105C6V Glycerol-3-phosphate dehydrogenase F2A31_10810 ENOG4105E98 transcriptional regulator DeoR family F2A31_10815 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) F2A31_10825 ENOG410830R acetyltransferase F2A31_10870 ENOG4108VWS Yaeq family F2A31_10875 ENOG4105CKI cobalamin synthesis protein F2A31_10910 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase F2A31_10925 ENOG4105C1G acyl-Coa dehydrogenase F2A31_10930 ENOG4105EPF Outer membrane porin F2A31_10935 ENOG4105NI3 Protein of unknown function (DUF3237) F2A31_10950 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase F2A31_10955 ENOG4107HP6 Transcriptional regulator F2A31_10980 ENOG4105C26 Dehydrogenase F2A31_10990 ENOG4105C8Y Acetylornithine aminotransferase F2A31_10995 ENOG4105D82 Glutamate dehydrogenase F2A31_11005 ENOG4107QPN acyl-Coa dehydrogenase F2A31_11010 ENOG4105C0A alcohol dehydrogenase F2A31_11065 ENOG4105CJP fad dependent oxidoreductase F2A31_11085 ENOG4105CT3 Monooxygenase F2A31_11100 ENOG4105CEP NADH dehydrogenase F2A31_11110 ENOG41087SS fad dependent oxidoreductase F2A31_11125 ENOG4107QNK )-transporter F2A31_11140 ENOG4105CHU acetyl-coa acetyltransferase F2A31_11145 ENOG4105CSU acyl-Coa dehydrogenase F2A31_11155 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr F2A31_11160 ENOG41061TZ Short-chain dehydrogenase reductase Sdr F2A31_11180 ENOG4105G2Y Transcriptional regulator F2A31_11185 ENOG4105CEY Amp-dependent synthetase and ligase F2A31_11190 ENOG4105C29 acyl-CoA thioesterase F2A31_11195 ENOG4105CSU acyl-Coa dehydrogenase F2A31_11210 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) F2A31_11215 ENOG4105C0R drug resistance transporter emrb qaca subfamily F2A31_11220 ENOG4105CW7 secretion protein, HlyD family F2A31_11225 ENOG4108VUY thioesterase Superfamily protein F2A31_11230 ENOG4105D52 delta-aminolevulinic acid dehydratase F2A31_11235 ENOG4108DN8 FAD dependent oxidoreductase F2A31_11240 ENOG4105ECP epimerase F2A31_11255 ENOG4105E9F Enoyl-CoA hydratase F2A31_11260 ENOG4105C94 Transporter F2A31_11265 ENOG4107RH8 nuclease SbcCD subunit D F2A31_11270 ENOG4105EYH Exonuclease F2A31_11280 ENOG4105DFA alanine racemase domain protein F2A31_11285 ENOG4105CZX twitching motility protein F2A31_11290 ENOG4105CZX twitching motility protein F2A31_11295 ENOG41090R7 Ferric uptake F2A31_11320 ENOG4105E7A Glutamine amidotransferase F2A31_11340 ENOG4107QKV phosphomannomutase F2A31_11345 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) F2A31_11350 ENOG4105C4R Atp-dependent dna helicase F2A31_11355 ENOG4108ZG0 Ompa motb domain protein F2A31_11360 ENOG4106HNH Acyl-transferase F2A31_11375 ENOG4107QMS site-determining protein F2A31_11390 ENOG4105CCF Lysine exporter protein (Lyse ygga) F2A31_11395 ENOG4105CNU cell division protein FtsK F2A31_11400 ENOG4105C3M thioredoxin reductase F2A31_11405 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) F2A31_11415 ENOG4105KEG ribosomal-protein-alanine acetyltransferase F2A31_11460 ENOG4108YXA Membrane F2A31_11470 ENOG4105C4K Nad synthetase F2A31_11495 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding F2A31_11515 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase F2A31_11520 ENOG4105C34 Pseudouridine synthase F2A31_11525 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane F2A31_11530 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) F2A31_11545 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) F2A31_11575 ENOG4105C5T Phosphoribosyl pyrophosphate synthase F2A31_11585 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) F2A31_11610 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) F2A31_11615 ENOG4107XGZ Hydrolase F2A31_11620 ENOG4105DWF phosphomethylpyrimidine kinase F2A31_11630 ENOG4109066 lysm domain bon superfamily protein F2A31_11640 ENOG4105CHR reductase F2A31_11645 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase F2A31_11650 ENOG4105VGS 50s ribosomal protein l32 F2A31_11655 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein F2A31_11660 ENOG4108BPE -transporting atpase F2A31_11665 ENOG4107RTD sua5 ycio yrdc ywlc family protein F2A31_11680 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) F2A31_11685 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) F2A31_11690 ENOG4105FE9 pseudouridine synthase F2A31_11720 ENOG4105DIB Oligopeptide-binding protein F2A31_11770 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F2A31_11775 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) F2A31_11790 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F2A31_11795 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F2A31_11800 ENOG4108UWD Iron-storage protein F2A31_11810 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) F2A31_11820 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) F2A31_11830 ENOG4105HF0 Membrane F2A31_11845 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY F2A31_11855 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) F2A31_11920 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) F2A31_11925 ENOG4105D1F ATP-binding protein F2A31_11950 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) F2A31_11960 ENOG4105CY0 Metallo-Beta-Lactamase F2A31_11980 ENOG4105K6H D-cysteine desulfhydrase F2A31_11985 ENOG4105CBX hi0933 family F2A31_12005 ENOG4105DP0 ferredoxin-NADP reductase F2A31_12010 ENOG4105DUM transcriptional regulator, lysR family F2A31_12030 ENOG4105C8S subunit m F2A31_12035 ENOG4105D65 subunit l F2A31_12040 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F2A31_12045 ENOG4107UFS subunit j F2A31_12050 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F2A31_12060 ENOG4108IEH NADH dehydrogenase subunit g F2A31_12065 ENOG4107QIZ NADH dehydrogenase F2A31_12070 ENOG4105GKE subunit e F2A31_12085 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain F2A31_12090 ENOG4105BZU Histidine kinase F2A31_12100 ENOG4105JJR Histidine kinase F2A31_12105 ENOG4107EXC regulatoR F2A31_12110 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F2A31_12120 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F2A31_12130 ENOG4107QTH restriction modification system DNA specificity domain F2A31_12155 ENOG4105CIG ABC transporter F2A31_12160 ENOG4105CGF Aromatic amino acid aminotransferase F2A31_12165 ENOG4105C85 amino acid F2A31_12175 ENOG4108RXX maleylacetoacetate isomerase F2A31_12200 ENOG4107SFI Major Facilitator superfamily F2A31_12210 ENOG4105C94 Transporter F2A31_12215 ENOG4105C94 Transporter F2A31_12220 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) F2A31_12245 ENOG4105C5T Phosphoribosyl pyrophosphate synthase F2A31_12290 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) F2A31_12295 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) F2A31_12300 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F2A31_12305 ENOG4105KPY Small multidrug resistance protein F2A31_12325 ENOG4105E3B Multicopper oxidase F2A31_12335 ENOG4105DJV ribulose-phosphate 3-epimerase F2A31_12360 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) F2A31_12365 ENOG41072GX Peptidase M22 Glycoprotease F2A31_12370 ENOG4108Z0R Transferase F2A31_12415 ENOG4105CRQ synthase (Component I) F2A31_12425 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) F2A31_12435 ENOG4108KPJ rna polymerase sigma factor F2A31_12440 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) F2A31_12445 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) F2A31_12520 ENOG4108ZHJ Organic hydroperoxide resistance protein F2A31_12525 ENOG4107QHF type ii secretion system protein e F2A31_12545 ENOG4105C2M dna polymerase I F2A31_12550 ENOG4108VIA integral membrane protein F2A31_12555 ENOG4105II7 pyrroline-5-carboxylate reductase F2A31_12560 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) F2A31_12570 ENOG4105C9X ppx gppa phosphatase F2A31_12580 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) F2A31_12595 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) F2A31_12620 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) F2A31_12630 ENOG4105W39 Membrane F2A31_12635 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase F2A31_12645 ENOG4105CYM Glutathione S-transferase F2A31_12665 ENOG4105CEY Amp-dependent synthetase and ligase F2A31_12670 ENOG4105N42 UPF0307 protein F2A31_12695 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase F2A31_12700 ENOG4105DJ0 Poly(A) Polymerase F2A31_12705 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein F2A31_12710 ENOG4105DXN mazG family F2A31_12725 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) F2A31_12740 ENOG4105C6T cysteine synthase F2A31_12745 ENOG4105BZU Histidine kinase F2A31_12750 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase F2A31_12755 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase F2A31_12760 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) F2A31_12785 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) F2A31_12790 ENOG4105W8H transhydrogenase (subunit alpha F2A31_12795 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) F2A31_12800 ENOG4108Z4X TRANSCRIPTIONal F2A31_12815 ENOG4105EV8 ectoine hydroxylase F2A31_12820 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) F2A31_12825 ENOG4108JPW Aminotransferase F2A31_12830 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase F2A31_12840 ENOG4105CAU Arsenical resistance protein, ArsH F2A31_12845 ENOG4105D6J arsenicaL-resistance protein F2A31_12855 ENOG41082YX Transcriptional regulator, arsr family F2A31_12870 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) F2A31_12880 ENOG4105CUZ uba thif-type nad fad binding protein F2A31_12890 ENOG4107QM5 aconitate hydratase F2A31_12895 ENOG4105F8V Hydrolase, tatD family F2A31_12910 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) F2A31_12940 ENOG4105BZU Histidine kinase F2A31_12945 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase F2A31_12950 ENOG4108ZP8 Acetolactate synthase small subunit F2A31_12955 ENOG4105C7K acetolactate synthase F2A31_12975 ENOG4105JF9 DNA polymerase III, delta F2A31_12980 ENOG4105DJY efflux transporter, rnd family, mfp subunit F2A31_12985 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) F2A31_12990 ENOG4105ENJ RND efflux system, outer membrane lipoprotein F2A31_13005 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH F2A31_13015 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) F2A31_13020 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) F2A31_13030 ENOG4105VW4 glutaredoxin 3 F2A31_13065 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase F2A31_13075 ENOG4105FFC UPF0187 protein F2A31_13080 ENOG4105DB7 PHP domain protein F2A31_13110 ENOG4108VPT UPF0234 protein F2A31_13120 ENOG4108ZGC gaf domain protein F2A31_13125 ENOG4105NAU thioesterase Superfamily protein F2A31_13135 ENOG4107U2T alpha beta F2A31_13140 ENOG4107QPB Beta-lactamase domain protein F2A31_13180 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase F2A31_13185 ENOG4105D6S protein involved in catabolism of external DNA F2A31_13215 ENOG4105E4C Lytic transglycosylase catalytic F2A31_13225 ENOG4105C9A Phoh family F2A31_13240 ENOG4105CNM Receptor F2A31_13310 ENOG4105CIY formyltetrahydrofolate deformylase F2A31_13315 ENOG41062JF Transcriptional regulator F2A31_13320 ENOG4107RGH Aldehyde dehydrogenase F2A31_13325 ENOG4105KDC 50s ribosomal protein l28 F2A31_13330 ENOG4105W0E 50S ribosomal protein L33 F2A31_13335 ENOG4105CKD glutathione-regulated potassium-efflux system protein F2A31_13355 ENOG4105VFU Rna-binding protein F2A31_13360 ENOG4105C4R Atp-dependent dna helicase F2A31_13375 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) F2A31_13385 ENOG4105KVH Transcriptional regulator F2A31_13390 ENOG4105CIS alcohol dehydrogenase F2A31_13395 ENOG41069P5 Protein slyX homolog F2A31_13400 ENOG4105C5H ABC transporter F2A31_13405 ENOG4108UVJ appr-1-p processing domain protein F2A31_13415 ENOG4105D1S lipid A biosynthesis F2A31_13490 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) F2A31_13515 ENOG4105DUM transcriptional regulator, lysR family F2A31_13525 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) F2A31_13530 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase F2A31_13535 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) F2A31_13540 ENOG4105KIR Thiol-disulfide oxidoreductase dcc F2A31_13570 ENOG4105EI2 Pseudouridine synthase F2A31_13580 ENOG4105C03 ribonuclease F2A31_13600 ENOG4105CSA Coproporphyrinogen iii oxidase F2A31_13610 ENOG4107QI1 Mate efflux family protein F2A31_13650 ENOG4105EW6 flavin reductase domain protein, FMN-binding F2A31_13665 ENOG4105BZ8 glutamate synthase F2A31_13675 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) F2A31_13680 ENOG4108IGT Dipeptidase F2A31_13715 ENOG4105C5X domain protein F2A31_13730 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) F2A31_13740 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase F2A31_13750 ENOG4108WQI RNA Polymerase F2A31_13760 ENOG4105E18 UPF0276 protein F2A31_13775 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) F2A31_13780 ENOG4108JU5 Magnesium and cobalt efflux protein F2A31_13785 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) F2A31_13795 ENOG4108VAU general secretion pathway protein G F2A31_13800 ENOG4105D7Q type ii secretion system F2A31_13805 ENOG4105C25 Primosomal protein n' F2A31_13815 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) F2A31_13825 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) F2A31_13830 ENOG4107QUT magnesium and cobalt transport protein CorA F2A31_13840 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) F2A31_13850 ENOG4107QYX exodeoxyribonuclease v alpha F2A31_13855 ENOG4107QKA exodeoxyribonuclease V beta F2A31_13860 ENOG4105DSY exodeoxyribonuclease V, gamma F2A31_13875 ENOG4105CSR polyphosphate kinase 2 F2A31_13885 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) F2A31_13895 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) F2A31_13900 ENOG4105I5W Transporter F2A31_13910 ENOG4105D7T ABC transporter F2A31_13920 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase F2A31_13925 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase F2A31_13940 ENOG4105D65 subunit l F2A31_13945 ENOG4108ZE9 Monovalent cation H antiporter subunit C F2A31_13950 ENOG4107R4Z monovalent cation h antiporter subunit d F2A31_13955 ENOG4105SC1 monovalent cation H antiporter subunit E F2A31_13960 ENOG4105W4C monovalent cation H antiporter subunit F F2A31_13965 ENOG4105KJM monovalent cation h antiporter subunit g F2A31_13970 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) F2A31_13980 ENOG4105CHV Transcription elongation factor NusA F2A31_14005 ENOG4107EJC Preprotein translocase subunit SecG F2A31_14015 ENOG4107QHF type ii secretion system protein e F2A31_14030 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) F2A31_14045 ENOG4105C2N RNA methyltransferase TrmH family group 3 F2A31_14055 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) F2A31_14065 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) F2A31_14095 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase F2A31_14155 ENOG4107ZXU DSBA oxidoreductase F2A31_14170 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) F2A31_14185 ENOG4105D3Y Na H antiporter F2A31_14240 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) F2A31_14245 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) F2A31_14250 ENOG4105PM1 preprotein translocase subunit SecE F2A31_14290 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) F2A31_14300 ENOG4105GVR general secretion pathway protein D F2A31_14315 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS F2A31_14340 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) F2A31_14345 ENOG4108NEV two component transcriptional regulator, LytTR family F2A31_14350 ENOG4108HRK Histidine kinase F2A31_14365 ENOG4108UTW Plays a role in the regulation of phosphate uptake F2A31_14380 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) F2A31_14385 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters F2A31_14390 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) F2A31_14395 ENOG4105CNI cell division protein FtsW F2A31_14410 ENOG4105CE1 Ferrous iron transport protein b F2A31_14420 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F2A31_14425 ENOG4105T95 Thiol disulfide interChange protein F2A31_14430 ENOG4105D6E homoserine dehydrogenase F2A31_14440 ENOG41061WM D-Alanyl-D-Alanine F2A31_14450 ENOG4107TUY Histidine kinase F2A31_14455 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F2A31_14460 ENOG4105CN1 protease F2A31_14465 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) F2A31_14470 ENOG4108K5H permease YjgP YjgQ family protein F2A31_14475 ENOG4108M8S permease YjgP YjgQ family protein F2A31_14500 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) F2A31_14510 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) F2A31_14515 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) F2A31_14520 ENOG4105BZU Histidine kinase F2A31_14535 ENOG4105C0P Mg chelatase subunit ChlI F2A31_14550 ENOG4105M6F mutator MutT protein F2A31_14570 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) F2A31_14605 ENOG4105C0P Mg chelatase subunit ChlI F2A31_14625 ENOG4105F0N pyrophosphate phospho-hydrolase F2A31_14640 ENOG4105CEY Amp-dependent synthetase and ligase F2A31_14645 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F2A31_14655 ENOG4105EN6 Membrane F2A31_14660 ENOG4105K5B UPF0225 protein F2A31_14665 ENOG4105EE5 Membrane protein terC F2A31_14675 ENOG4108URH decarboxylase F2A31_14680 ENOG4105C0R drug resistance transporter emrb qaca subfamily F2A31_14690 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) F2A31_14705 ENOG4105CCT upf0313 protein F2A31_14715 ENOG4105D94 Major Facilitator Superfamily F2A31_14725 ENOG4105C6T cysteine synthase F2A31_14760 ENOG4105C94 Transporter F2A31_14775 ENOG4107QN1 sodium solute F2A31_14780 ENOG41062QD Membrane F2A31_14785 ENOG4105BZU Histidine kinase F2A31_14810 ENOG4108WZM domain protein F2A31_14815 ENOG4105C79 DNA protecting protein DprA F2A31_14830 ENOG4108IND Tetr family transcriptional regulator F2A31_14835 ENOG4105F27 Major Facilitator F2A31_14845 ENOG4108V06 Glutathione peroxidase F2A31_14870 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) F2A31_14880 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) F2A31_14895 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) F2A31_14920 ENOG4105FDK ABC transporter F2A31_14925 ENOG4105FAV ABC, transporter F2A31_14935 ENOG4105EZR dyp-type peroxidase family protein F2A31_14960 ENOG4105EUB pirin domain protein F2A31_14970 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) F2A31_14975 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) F2A31_14990 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) F2A31_14995 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) F2A31_15005 ENOG4106MP8 UPF0754 membrane protein F2A31_15010 ENOG4108VBZ doxx family F2A31_15015 ENOG4105DQR SNARE associated Golgi F2A31_15030 ENOG4107QJE Chromosome Partitioning Protein F2A31_15040 ENOG4107PSF BolA-like protein F2A31_15060 ENOG4105CSH Transporter F2A31_15065 ENOG4105E39 Enoyl-CoA hydratase F2A31_15070 ENOG4105E39 Enoyl-CoA hydratase F2A31_15075 ENOG4105C1G acyl-Coa dehydrogenase F2A31_15085 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase F2A31_15090 ENOG4105C26 Dehydrogenase F2A31_15100 ENOG4105C85 amino acid F2A31_15105 ENOG4105M4H endoribonuclease L-psp F2A31_15120 ENOG4105EW9 transcriptional regulator AsnC family F2A31_15135 ENOG4108W0I acetyltransferase F2A31_15140 ENOG4105D3G Pseudouridine synthase F2A31_15145 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) F2A31_15160 ENOG4107UNZ domain protein F2A31_15170 ENOG4108I0Z Aconitate hydratase F2A31_15175 ENOG4105BZN citrate synthase F2A31_15190 ENOG4105CR4 methylisocitrate lyase F2A31_15195 ENOG4105DRR Transcriptional regulator, GntR family F2A31_15200 ENOG4105CGF Aromatic amino acid aminotransferase F2A31_15205 ENOG4105CXG d-lactate dehydrogenase F2A31_15220 ENOG41073TP transcriptional regulator F2A31_15225 ENOG4105DAA L-lactate F2A31_15230 ENOG4107QKV phosphomannomutase F2A31_15235 ENOG4105CMR udp-glucose 4-epimerase F2A31_15245 ENOG4105C6Y Udp-glucose 6-dehydrogenase F2A31_15250 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase F2A31_15265 ENOG4107UKG Glycosyl transferase, family 4 F2A31_15280 ENOG4108IJ1 Dehydrogenase F2A31_15285 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase F2A31_15290 ENOG4107EF8 Glycosyl transferase (Group 1 F2A31_15325 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase F2A31_15330 ENOG4105J5G Transferase hexapeptide repeat containing protein F2A31_15335 ENOG4107R5Z Oxidoreductase domain protein F2A31_15340 ENOG4107QQG Dehydrogenase F2A31_15345 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase F2A31_15350 ENOG4105DAY polysaccharide export protein F2A31_15360 ENOG4105D75 Capsular exopolysaccharide family F2A31_15365 ENOG4108V1T peptidylprolyl cis-trans isomerase F2A31_15380 ENOG4105CJR Integral membrane protein (MviN F2A31_15385 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase F2A31_15390 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase F2A31_15405 ENOG4105HSS phospholipase C F2A31_15430 ENOG41062JF Transcriptional regulator F2A31_15445 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) F2A31_15450 ENOG4105UBK short-chain dehydrogenase reductase F2A31_15460 ENOG4107QZM n-acetylglutamate synthase F2A31_15465 ENOG4105GVF (ABC) transporter F2A31_15470 ENOG4105GVF (ABC) transporter F2A31_15475 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) F2A31_15480 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component F2A31_15485 ENOG4108VM9 ABC, transporter F2A31_15490 ENOG4108R86 Transcriptional regulator F2A31_15495 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase F2A31_15510 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) F2A31_15520 ENOG4105DTN riboflavin biosynthesis protein ribF F2A31_15525 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) F2A31_15535 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase F2A31_15575 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) F2A31_15615 ENOG4107T8T UPF0173 metal-dependent hydrolase F2A31_15640 ENOG4105CVE Lytic murein transglycosylase F2A31_15645 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit F2A31_15650 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) F2A31_15665 ENOG4105DFU Cell wall formation (By similarity) F2A31_15690 ENOG4105DQS Transcriptional regulator F2A31_15695 ENOG4105DU1 integral membrane protein, terc F2A31_15710 ENOG4107QUY Guanine deaminase F2A31_15715 ENOG4108UGV hypoxanthine phosphoribosyltransferase F2A31_15725 ENOG4105T95 Thiol disulfide interChange protein F2A31_15735 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins F2A31_15750 ENOG4105VG0 50S ribosomal protein l34