locus-tag	class	description
A3K93_00005	COG0784	Response regulator, receiver
A3K93_00005	COG2205	protein histidine kinase activity
A3K93_00010	COG3706	GGDEF domain
A3K93_00010	COG0745	RESPONSE REGULATOR receiver
A3K93_00060	COG3706	GGDEF domain
A3K93_00075	COG1393	Belongs to the ArsC family
A3K93_00080	COG0708	Exodeoxyribonuclease III
A3K93_00100	COG1278	Cold shock
A3K93_00115	COG0189	ligase activity
A3K93_00120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A3K93_00135	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A3K93_00145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3K93_00175	COG2119	membrane
A3K93_00180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3K93_00180	COG0426	domain, Protein
A3K93_00195	COG0675	Transposase, IS605 OrfB family
A3K93_00220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A3K93_00240	COG0640	Transcriptional regulator
A3K93_00245	COG1902	pentaerythritol trinitrate reductase activity
A3K93_00250	COG1519	Transferase
A3K93_00255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A3K93_00260	COG0668	transmembrane transport
A3K93_00265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A3K93_00285	COG0675	Transposase, IS605 OrfB family
A3K93_00290	COG0415	Belongs to the DNA photolyase family
A3K93_00295	COG0307	riboflavin synthase, alpha
A3K93_00300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A3K93_00320	COG0784	Response regulator, receiver
A3K93_00320	COG2205	protein histidine kinase activity
A3K93_00325	COG3162	membrane
A3K93_00330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3K93_00345	COG3706	GGDEF domain
A3K93_00365	COG2814	Major facilitator Superfamily
A3K93_00370	COG0629	single-stranded DNA binding
A3K93_00375	COG0450	alkyl hydroperoxide reductase
A3K93_00405	COG2963	transposase activity
A3K93_00415	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
A3K93_00445	COG3158	transport of potassium into the cell
A3K93_00465	COG2826	transposase and inactivated derivatives, IS30 family
A3K93_00490	COG3293	Transposase
A3K93_00500	COG2801	Transposase and inactivated derivatives
A3K93_00525	COG0675	Transposase, IS605 OrfB family
A3K93_00545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A3K93_00565	COG0531	amino acid
A3K93_00570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3K93_00575	COG0697	spore germination
A3K93_00600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A3K93_00605	COG0131	Imidazoleglycerol-phosphate dehydratase
A3K93_00660	COG1024	Enoyl-CoA hydratase
A3K93_00660	COG1250	3-hydroxyacyl-CoA dehydrogenase
A3K93_00665	COG3706	GGDEF domain
A3K93_00690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A3K93_00705	COG3275	phosphorelay sensor kinase activity
A3K93_00715	COG0181	hydroxymethylbilane synthase activity
A3K93_00825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A3K93_00835	COG0085	RNA polymerase activity
A3K93_00865	COG2056	Na+-H+ antiporter family
A3K93_00880	COG0326	Molecular chaperone. Has ATPase activity
A3K93_00905	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A3K93_00915	COG0427	acetyl-CoA hydrolase
A3K93_00920	COG2205	protein histidine kinase activity
A3K93_00925	COG0745	RESPONSE REGULATOR receiver
A3K93_00940	COG3385	transposase activity
A3K93_00975	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A3K93_00985	COG2226	methyltransferase
A3K93_01005	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A3K93_01010	COG1074	ATP-dependent DNA helicase activity
A3K93_01015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A3K93_01020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A3K93_01035	COG2841	Protein conserved in bacteria
A3K93_01040	COG0789	Transcriptional regulator
A3K93_01045	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A3K93_01055	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A3K93_01080	COG4535	Mg2 and Co2 transporter CorC
A3K93_01085	COG0425	Belongs to the sulfur carrier protein TusA family
A3K93_01090	COG0644	oxidoreductase
A3K93_01090	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
A3K93_01100	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A3K93_01115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3K93_01120	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A3K93_01130	COG0493	'glutamate synthase
A3K93_01155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3K93_01180	COG0751	glycine-tRNA ligase activity
A3K93_01190	COG0517	IMP dehydrogenase activity
A3K93_01195	COG0471	metal ion transport
A3K93_01205	COG1983	PspC domain protein
A3K93_01235	COG0318	PFAM AMP-dependent synthetase and ligase
A3K93_01240	COG1530	ribonuclease E activity
A3K93_01250	COG0546	phosphoglycolate phosphatase activity
A3K93_01255	COG3971	2-oxopent-4-enoate hydratase activity
A3K93_01260	COG4569	acetaldehyde dehydrogenase (acetylating) activity
A3K93_01270	COG3385	transposase activity
A3K93_01285	COG0583	DNA-binding transcription factor activity
A3K93_01290	COG4638	Rieske (2fe-2S)
A3K93_01305	COG1028	Short-chain dehydrogenase reductase Sdr
A3K93_01310	COG3384	dioxygenase
A3K93_01315	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3K93_01325	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A3K93_01330	COG0753	catalase activity
A3K93_01375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A3K93_01390	COG0473	3-isopropylmalate dehydrogenase activity
A3K93_01440	COG1560	Kdo2-lipid A biosynthetic process
A3K93_01450	COG2900	Belongs to the SlyX family
A3K93_01480	COG0210	DNA helicase
A3K93_01485	COG0724	RNA recognition motif
A3K93_01500	COG4651	solute:proton antiporter activity
A3K93_01500	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A3K93_01505	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A3K93_01510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A3K93_01525	COG0788	formyltetrahydrofolate deformylase activity
A3K93_01610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A3K93_01610	COG2813	Specifically methylates the guanine in position
A3K93_01620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A3K93_01630	COG4774	siderophore transport
A3K93_01640	COG0740	serine-type endopeptidase activity
A3K93_01660	COG0280	phosphate acetyltransferase
A3K93_01660	COG0857	belongs to the CobB CobQ family
A3K93_01665	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A3K93_01690	COG0793	Belongs to the peptidase S41A family
A3K93_01700	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A3K93_01715	COG0084	hydrolase, TatD family'
A3K93_01730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A3K93_01740	COG1162	GTPase activity
A3K93_01745	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A3K93_01750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A3K93_01760	COG1538	Outer membrane efflux protein
A3K93_01765	COG1136	(ABC) transporter
A3K93_01765	COG0577	efflux transmembrane transporter activity
A3K93_01770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3K93_01795	COG0028	Belongs to the TPP enzyme family
A3K93_01800	COG0440	acetolactate synthase activity
A3K93_01820	COG4585	Histidine kinase
A3K93_01825	COG2975	iron-sulfur cluster assembly
A3K93_01845	COG1426	Protein conserved in bacteria
A3K93_01865	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A3K93_01890	COG3956	TIGRFAM MazG family protein
A3K93_01895	COG1555	photosystem II stabilization
A3K93_01900	COG0617	tRNA 3'-terminal CCA addition
A3K93_01905	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A3K93_01920	COG1660	Displays ATPase and GTPase activities
A3K93_01930	COG3028	Belongs to the UPF0307 family
A3K93_01935	COG5002	protein histidine kinase activity
A3K93_01940	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A3K93_01995	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A3K93_02025	COG3223	Belongs to the PsiE family
A3K93_02035	COG1960	acyl-CoA dehydrogenase activity
A3K93_02040	COG1960	acyl-CoA dehydrogenase activity
A3K93_02050	COG2205	protein histidine kinase activity
A3K93_02055	COG0745	RESPONSE REGULATOR receiver
A3K93_02065	COG1113	amino acid transport
A3K93_02075	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A3K93_02095	COG2096	Adenosyltransferase
A3K93_02100	COG4206	TonB-dependent receptor
A3K93_02110	COG0133	tryptophan synthase activity
A3K93_02150	COG0285	dihydrofolate synthase activity
A3K93_02160	COG0450	alkyl hydroperoxide reductase
A3K93_02175	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A3K93_02180	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A3K93_02215	COG5001	Diguanylate cyclase
A3K93_02215	COG3300	MHYT domain
A3K93_02265	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A3K93_02270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A3K93_02280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A3K93_02320	COG0494	nUDIX hydrolase
A3K93_02330	COG1214	PFAM Peptidase M22, glycoprotease
A3K93_02335	COG1968	undecaprenyl-diphosphatase activity
A3K93_02355	COG4269	membrane
A3K93_02370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A3K93_02375	COG2076	Multidrug Resistance protein
A3K93_02380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A3K93_02390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A3K93_02420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A3K93_02425	COG3545	Serine hydrolase
A3K93_02435	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A3K93_02445	COG0730	response to heat
A3K93_02455	COG1196	nuclear chromosome segregation
A3K93_02465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A3K93_02470	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A3K93_02475	COG2193	ferroxidase activity
A3K93_02480	COG4372	Transposase
A3K93_02505	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A3K93_02510	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A3K93_02515	COG0009	L-threonylcarbamoyladenylate synthase
A3K93_02520	COG3101	peptidyl-lysine hydroxylation
A3K93_02525	COG1399	metal-binding, possibly nucleic acid-binding protein
A3K93_02530	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A3K93_02535	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A3K93_02540	COG1028	Short-chain dehydrogenase reductase Sdr
A3K93_02545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A3K93_02550	COG1652	LysM domain
A3K93_02555	COG1522	sequence-specific DNA binding
A3K93_02570	COG0251	oxidation-reduction process
A3K93_02575	COG1113	amino acid transport
A3K93_02595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A3K93_02605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A3K93_02620	COG0456	acetyltransferase
A3K93_02630	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A3K93_02635	COG0492	ferredoxin-NADP+ reductase activity
A3K93_02640	COG1674	ftsk spoiiie
A3K93_02640	COG0531	amino acid
A3K93_02650	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A3K93_02670	COG0204	Acyl-transferase
A3K93_02675	COG2885	chlorophyll binding
A3K93_02680	COG0210	DNA helicase
A3K93_02685	COG0756	dUTP diphosphatase activity
A3K93_02690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3K93_02695	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A3K93_02700	COG0121	glutamine amidotransferase
A3K93_02715	COG2914	Belongs to the UPF0125 (RnfH) family
A3K93_02720	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A3K93_02725	COG0735	belongs to the Fur family
A3K93_02750	COG0420	3'-5' exonuclease activity
A3K93_02765	COG2050	protein possibly involved in aromatic compounds catabolism
A3K93_02770	COG1566	PFAM secretion protein HlyD family protein
A3K93_02775	COG2814	Major facilitator Superfamily
A3K93_02780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A3K93_02805	COG2801	Transposase and inactivated derivatives
A3K93_02810	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A3K93_02815	COG0477	Major facilitator Superfamily
A3K93_02825	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A3K93_02835	COG3177	Filamentation induced by cAMP protein fic
A3K93_02860	COG2801	Transposase and inactivated derivatives
A3K93_02875	COG2814	Major facilitator Superfamily
A3K93_02885	COG2814	Major facilitator Superfamily
A3K93_02895	COG0179	Fumarylacetoacetate (FAA) hydrolase
A3K93_02905	COG1012	belongs to the aldehyde dehydrogenase family
A3K93_02910	COG3384	dioxygenase
A3K93_02920	COG3971	2-oxopent-4-enoate hydratase activity
A3K93_02935	COG0477	Major facilitator Superfamily
A3K93_02950	COG1960	acyl-CoA dehydrogenase activity
A3K93_02955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3K93_02965	COG1028	Short-chain dehydrogenase reductase Sdr
A3K93_02980	COG2271	Major facilitator Superfamily
A3K93_02990	COG1846	Transcriptional regulator
A3K93_03000	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
A3K93_03035	COG2801	Transposase and inactivated derivatives
A3K93_03045	COG3328	transposase activity
A3K93_03050	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A3K93_03060	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A3K93_03065	COG1077	Cell shape determining protein MreB Mrl
A3K93_03070	COG1792	Involved in formation and maintenance of cell shape
A3K93_03075	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A3K93_03080	COG0424	maF-like protein
A3K93_03085	COG1530	ribonuclease E activity
A3K93_03090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A3K93_03130	COG1113	amino acid transport
A3K93_03135	COG2828	Protein conserved in bacteria
A3K93_03145	COG0142	geranyltranstransferase activity
A3K93_03150	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3K93_03185	COG0560	Phosphoserine phosphatase
A3K93_03190	COG0745	RESPONSE REGULATOR receiver
A3K93_03190	COG3706	GGDEF domain
A3K93_03215	COG3328	transposase activity
A3K93_03225	COG3293	Transposase
A3K93_03235	COG0525	valine-tRNA ligase activity
A3K93_03245	COG1028	Short-chain dehydrogenase reductase Sdr
A3K93_03250	COG3706	GGDEF domain
A3K93_03255	COG2066	Belongs to the glutaminase family
A3K93_03265	COG2376	Dihydroxyacetone kinase
A3K93_03270	COG2852	Protein conserved in bacteria
A3K93_03275	COG2801	Transposase and inactivated derivatives
A3K93_03300	COG0306	phosphate transporter
A3K93_03310	COG4607	ABC-type enterochelin transport system periplasmic component
A3K93_03325	COG4771	TonB-dependent receptor
A3K93_03360	COG4181	ATPase activity
A3K93_03365	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A3K93_03375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A3K93_03390	COG0583	DNA-binding transcription factor activity
A3K93_03400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A3K93_03405	COG1773	rubredoxin
A3K93_03410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A3K93_03435	COG2354	Protein conserved in bacteria
A3K93_03440	COG2321	neutral zinc metallopeptidase
A3K93_03465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A3K93_03465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A3K93_03485	COG2009	succinate dehydrogenase
A3K93_03490	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A3K93_03495	COG1053	succinate dehydrogenase
A3K93_03500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A3K93_03515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3K93_03525	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A3K93_03550	COG0175	sulfate reduction
A3K93_03590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A3K93_03605	COG0477	Major facilitator Superfamily
A3K93_03635	COG3293	Transposase
A3K93_03670	COG0742	ribosomal rna small subunit methyltransferase
A3K93_03675	COG0768	penicillin binding
A3K93_03700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A3K93_03705	COG2878	Part of a membrane complex involved in electron transport
A3K93_03710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A3K93_03720	COG3384	dioxygenase
A3K93_03730	COG2234	aminopeptidase activity
A3K93_03740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A3K93_03785	COG1484	DNA-dependent DNA replication
A3K93_03820	COG0546	phosphoglycolate phosphatase activity
A3K93_03845	COG3079	Belongs to the UPF0149 family
A3K93_03850	COG0006	proline dipeptidase activity
A3K93_03870	COG2155	Conserved Protein
A3K93_03875	COG3293	Transposase
A3K93_03880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A3K93_03885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A3K93_03915	COG2816	NAD+ diphosphatase activity
A3K93_03925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A3K93_03930	COG1388	LysM domain
A3K93_03930	COG0741	lytic transglycosylase activity
A3K93_03940	COG4174	ABC transporter (Permease)
A3K93_03945	COG4239	(ABC) transporter, permease
A3K93_03950	COG4172	Belongs to the ABC transporter superfamily
A3K93_03985	COG0833	amino acid
A3K93_03995	COG0833	amino acid
A3K93_04000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A3K93_04005	COG0418	dihydroorotase activity
A3K93_04010	COG2203	Gaf domain
A3K93_04010	COG3706	GGDEF domain
A3K93_04010	COG4251	negative regulation of phosphorylation
A3K93_04010	COG5001	Diguanylate cyclase
A3K93_04025	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3K93_04025	COG1902	pentaerythritol trinitrate reductase activity
A3K93_04035	COG1741	Belongs to the pirin family
A3K93_04050	COG3739	integral membrane protein
A3K93_04065	COG3706	GGDEF domain
A3K93_04085	COG0302	gtp cyclohydrolase
A3K93_04095	COG0134	indole-3-glycerol-phosphate synthase activity
A3K93_04100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A3K93_04105	COG0512	Glutamine amidotransferase of anthranilate synthase
A3K93_04120	COG3161	chorismate lyase activity
A3K93_04125	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A3K93_04170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A3K93_04180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3K93_04185	COG1960	acyl-CoA dehydrogenase activity
A3K93_04190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A3K93_04195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3K93_04220	COG0556	nucleotide-excision repair
A3K93_04250	COG0702	epimerase
A3K93_04255	COG1733	regulation of RNA biosynthetic process
A3K93_04265	COG2814	Major facilitator Superfamily
A3K93_04275	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A3K93_04280	COG0671	phosphoesterase, PA-phosphatase related
A3K93_04290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A3K93_04295	COG0076	glutamate decarboxylase activity
A3K93_04305	COG0573	inorganic phosphate transmembrane transporter activity
A3K93_04315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A3K93_04325	COG0616	signal peptide processing
A3K93_04335	COG2826	transposase and inactivated derivatives, IS30 family
A3K93_04375	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A3K93_04380	COG1686	Belongs to the peptidase S11 family
A3K93_04400	COG1388	LysM domain
A3K93_04400	COG4942	peptidase
A3K93_04405	COG0583	DNA-binding transcription factor activity
A3K93_04410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A3K93_04415	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A3K93_04420	COG1067	ATP-dependent peptidase activity
A3K93_04455	COG1509	lysine 2,3-aminomutase activity
A3K93_04465	COG1966	Carbon starvation protein
A3K93_04470	COG2879	small protein
A3K93_04480	COG0714	Associated with various cellular activities
A3K93_04510	COG1765	OsmC-like protein
A3K93_04520	COG0667	Aldo Keto reductase
A3K93_04540	COG0540	Belongs to the ATCase OTCase family
A3K93_04565	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A3K93_04570	COG0659	secondary active sulfate transmembrane transporter activity
A3K93_04580	COG2363	Small membrane protein
A3K93_04600	COG0513	Belongs to the DEAD box helicase family
A3K93_04610	COG0778	Nitroreductase
A3K93_04635	COG0167	dihydroorotate dehydrogenase activity
A3K93_04665	COG4783	chaperone-mediated protein folding
A3K93_04670	COG1610	YqeY-like protein
A3K93_04675	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A3K93_04680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A3K93_04695	COG2801	Transposase and inactivated derivatives
A3K93_04780	COG0612	Peptidase, M16
A3K93_04815	COG0352	thiamine-phosphate diphosphorylase activity
A3K93_04825	COG3293	Transposase
A3K93_04945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A3K93_04955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A3K93_04975	COG3385	transposase activity
A3K93_04980	COG1280	lysine exporter protein (LysE YggA)
A3K93_04985	COG0505	Belongs to the CarA family
A3K93_05000	COG0517	IMP dehydrogenase activity
A3K93_05000	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A3K93_05005	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A3K93_05015	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A3K93_05020	COG1137	ATPase activity
A3K93_05025	COG1538	Outer membrane efflux protein
A3K93_05030	COG2274	protein secretion by the type I secretion system
A3K93_05050	COG0589	response to stress
A3K93_05065	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A3K93_05075	COG2203	Gaf domain
A3K93_05075	COG5001	Diguanylate cyclase
A3K93_05075	COG4251	negative regulation of phosphorylation
A3K93_05075	COG3706	GGDEF domain
A3K93_05110	COG2011	ABC-type metal ion transport system permease component
A3K93_05115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A3K93_05120	COG1464	Belongs to the NlpA lipoprotein family
A3K93_05165	COG3328	transposase activity
A3K93_05170	COG0151	Belongs to the GarS family
A3K93_05175	COG0138	bifunctional purine biosynthesis protein purh
A3K93_05180	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A3K93_05220	COG2814	Major facilitator Superfamily
A3K93_05230	COG2204	response regulator
A3K93_05235	COG3852	Histidine kinase
A3K93_05255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A3K93_05260	COG0575	Belongs to the CDS family
A3K93_05275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A3K93_05290	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A3K93_05295	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A3K93_05310	COG2137	regulation of response to DNA damage stimulus
A3K93_05315	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A3K93_05320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A3K93_05325	COG1011	Hydrolase
A3K93_05330	COG1218	3'(2'),5'-bisphosphate nucleotidase
A3K93_05340	COG0268	Binds directly to 16S ribosomal RNA
A3K93_05345	COG0702	epimerase
A3K93_05350	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A3K93_05360	COG0745	RESPONSE REGULATOR receiver
A3K93_05370	COG0675	Transposase, IS605 OrfB family
A3K93_05385	COG2850	peptidyl-arginine hydroxylation
A3K93_05400	COG0424	maF-like protein
A3K93_05410	COG0126	phosphoglycerate kinase activity
A3K93_05420	COG0191	fructose-bisphosphate aldolase activity
A3K93_05425	COG0697	spore germination
A3K93_05445	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A3K93_05455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A3K93_05460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3K93_05515	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A3K93_05555	COG0316	Belongs to the HesB IscA family
A3K93_05560	COG0822	iron-sulfur transferase activity
A3K93_05585	COG0776	regulation of translation
A3K93_05590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A3K93_05610	COG1585	Membrane protein implicated in regulation of membrane protease activity
A3K93_05620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3K93_05640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A3K93_05645	COG0569	domain protein
A3K93_05650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A3K93_05655	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A3K93_05665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3K93_05685	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A3K93_05690	COG0542	response to heat
A3K93_05710	COG1309	transcriptional regulator
A3K93_05720	COG0372	Belongs to the citrate synthase family
A3K93_05740	COG3293	Transposase
A3K93_05755	COG3706	GGDEF domain
A3K93_05765	COG0439	Biotin carboxylase
A3K93_05780	COG4589	Belongs to the CDS family
A3K93_05795	COG2453	phosphatase
A3K93_05795	COG0671	phosphoesterase, PA-phosphatase related
A3K93_05800	COG2267	carboxylic ester hydrolase activity
A3K93_05805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A3K93_05840	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A3K93_05845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A3K93_05880	COG0596	Alpha beta hydrolase
A3K93_05915	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A3K93_05920	COG2223	nitrite transmembrane transporter activity
A3K93_05930	COG0500	methyltransferase
A3K93_05945	COG2323	membrane
A3K93_05975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A3K93_05975	COG1017	nitric oxide dioxygenase activity
A3K93_05980	COG0318	PFAM AMP-dependent synthetase and ligase
A3K93_05995	COG0804	urea catabolic process
A3K93_06015	COG0829	nickel cation binding
A3K93_06020	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A3K93_06025	COG0830	nickel cation binding
A3K93_06030	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A3K93_06050	COG0789	Transcriptional regulator
A3K93_06060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A3K93_06065	COG0640	Transcriptional regulator
A3K93_06085	COG3122	Protein conserved in bacteria
A3K93_06090	COG1132	(ABC) transporter
A3K93_06105	COG0509	glycine decarboxylation via glycine cleavage system
A3K93_06110	COG2814	Major facilitator Superfamily
A3K93_06120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A3K93_06125	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A3K93_06130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A3K93_06180	COG1960	acyl-CoA dehydrogenase activity
A3K93_06190	COG1525	nuclease
A3K93_06200	COG2814	Major facilitator Superfamily
A3K93_06205	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A3K93_06210	COG2207	Transcriptional regulator
A3K93_06215	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A3K93_06220	COG0730	response to heat
A3K93_06225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A3K93_06275	COG1960	acyl-CoA dehydrogenase activity
A3K93_06280	COG1960	acyl-CoA dehydrogenase activity
A3K93_06330	COG0552	protein localization to endoplasmic reticulum
A3K93_06335	COG0612	Peptidase, M16
A3K93_06370	COG0133	tryptophan synthase activity
A3K93_06380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3K93_06400	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A3K93_06430	COG0537	adenosine 5'-monophosphoramidase activity
A3K93_06450	COG1294	oxidase, subunit
A3K93_06455	COG4890	Cyd operon protein YbgT
A3K93_06475	COG0772	Belongs to the SEDS family
A3K93_06490	COG0148	phosphopyruvate hydratase activity
A3K93_06525	COG1902	pentaerythritol trinitrate reductase activity
A3K93_06525	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3K93_06540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A3K93_06545	COG0583	DNA-binding transcription factor activity
A3K93_06550	COG0024	Methionine aminopeptidase
A3K93_06555	COG1114	Component of the transport system for branched-chain amino acids
A3K93_06575	COG0786	glutamate:sodium symporter activity
A3K93_06615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A3K93_06635	COG0477	Major facilitator Superfamily
A3K93_06640	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
A3K93_06655	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A3K93_06675	COG2814	Major facilitator Superfamily
A3K93_06700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3K93_06705	COG2890	protein-(glutamine-N5) methyltransferase activity
A3K93_06710	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A3K93_06725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A3K93_06760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A3K93_06765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A3K93_06770	COG1845	cytochrome c oxidase, subunit III
A3K93_06775	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A3K93_06785	COG0360	Binds together with S18 to 16S ribosomal RNA
A3K93_06800	COG0305	Participates in initiation and elongation during chromosome replication
A3K93_06805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A3K93_06820	COG1305	Transglutaminase-like
A3K93_06830	COG2308	Evidence 4 Homologs of previously reported genes of
A3K93_06840	COG0069	glutamate synthase activity
A3K93_06860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A3K93_06865	COG1454	alcohol dehydrogenase
A3K93_06870	COG0824	Thioesterase
A3K93_06895	COG0183	Belongs to the thiolase family
A3K93_06900	COG3385	transposase activity
A3K93_06915	COG0583	DNA-binding transcription factor activity
A3K93_06920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A3K93_06935	COG0589	response to stress
A3K93_06950	COG0308	aminopeptidase N
A3K93_06985	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A3K93_06990	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A3K93_07005	COG2431	L-lysine efflux transmembrane transporter activity
A3K93_07020	COG0776	regulation of translation
A3K93_07030	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A3K93_07040	COG0590	tRNA wobble adenosine to inosine editing
A3K93_07050	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A3K93_07080	COG1309	transcriptional regulator
A3K93_07085	COG0084	hydrolase, TatD family'
A3K93_07105	COG1663	tetraacyldisaccharide 4'-kinase activity
A3K93_07110	COG1132	(ABC) transporter
A3K93_07120	COG0811	peptide transport
A3K93_07125	COG1475	DNA binding
A3K93_07130	COG1192	Involved in chromosome partitioning
A3K93_07140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A3K93_07145	COG3178	'Phosphotransferase
A3K93_07155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A3K93_07160	COG1923	regulation of RNA biosynthetic process
A3K93_07165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A3K93_07170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A3K93_07175	COG0802	atpase or kinase
A3K93_07210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A3K93_07230	COG1643	Atp-dependent helicase
A3K93_07235	COG0450	alkyl hydroperoxide reductase
A3K93_07260	COG3634	alkyl hydroperoxide reductase activity
A3K93_07275	COG1280	lysine exporter protein (LysE YggA)
A3K93_07295	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A3K93_07295	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A3K93_07330	COG0204	Acyl-transferase
A3K93_07355	COG0012	GTP binding
A3K93_07375	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A3K93_07405	COG0386	Belongs to the glutathione peroxidase family
A3K93_07410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A3K93_07415	COG0436	Aminotransferase
A3K93_07430	COG2351	hydroxyisourate hydrolase activity
A3K93_07470	COG4372	Transposase
A3K93_07495	COG1686	Belongs to the peptidase S11 family
A3K93_07500	COG1252	NADH dehydrogenase
A3K93_07505	COG1047	Peptidyl-prolyl cis-trans
A3K93_07525	COG4783	chaperone-mediated protein folding
A3K93_07530	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A3K93_07545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A3K93_07560	COG0527	aspartate kinase activity
A3K93_07570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A3K93_07585	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A3K93_07590	COG2252	PERMEase
A3K93_07610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A3K93_07615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3K93_07625	COG0693	protein deglycase activity
A3K93_07630	COG1960	acyl-CoA dehydrogenase activity
A3K93_07635	COG1301	dicarboxylic acid transport
A3K93_07640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A3K93_07645	COG3139	Protein of unknown function (DUF1315)
A3K93_07650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A3K93_07655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A3K93_07660	COG0494	nUDIX hydrolase
A3K93_07670	COG0642	Histidine kinase
A3K93_07675	COG0745	RESPONSE REGULATOR receiver
A3K93_07685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A3K93_07695	COG1720	tRNA m6t6A37 methyltransferase activity
A3K93_07705	COG4993	Dehydrogenase
A3K93_07715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3K93_07720	COG3634	alkyl hydroperoxide reductase activity
A3K93_07755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A3K93_07790	COG3385	transposase activity
A3K93_07795	COG1944	ATP diphosphatase activity
A3K93_07810	COG1131	(ABC) transporter
A3K93_07815	COG0842	Transport permease protein
A3K93_07830	COG2951	lytic endotransglycosylase activity
A3K93_07850	COG3385	transposase activity
A3K93_07860	COG0052	Belongs to the universal ribosomal protein uS2 family
A3K93_07865	COG0024	Methionine aminopeptidase
A3K93_07890	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A3K93_07905	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A3K93_07910	COG0571	ribonuclease III activity
A3K93_07935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3K93_07965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A3K93_07975	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A3K93_07980	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A3K93_07995	COG4208	sulfate ABC transporter
A3K93_08000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A3K93_08005	COG0583	DNA-binding transcription factor activity
A3K93_08020	COG0602	queuosine metabolic process
A3K93_08025	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A3K93_08035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A3K93_08045	COG0583	DNA-binding transcription factor activity
A3K93_08050	COG2353	YceI-like domain
A3K93_08055	COG1051	belongs to the nudix hydrolase family
A3K93_08055	COG1056	cytidyltransferase-related domain
A3K93_08060	COG1024	Enoyl-CoA hydratase
A3K93_08065	COG0778	Nitroreductase
A3K93_08070	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A3K93_08075	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A3K93_08080	COG0583	DNA-binding transcription factor activity
A3K93_08100	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A3K93_08100	COG0047	phosphoribosylformylglycinamidine synthase activity
A3K93_08105	COG2234	aminopeptidase activity
A3K93_08120	COG2255	four-way junction helicase activity
A3K93_08140	COG0824	Thioesterase
A3K93_08160	COG0823	Involved in the tonB-independent uptake of proteins
A3K93_08165	COG2885	chlorophyll binding
A3K93_08180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A3K93_08215	COG0628	permease
A3K93_08225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A3K93_08245	COG0658	competence protein
A3K93_08245	COG2333	competence protein COMEC
A3K93_08250	COG1136	(ABC) transporter
A3K93_08255	COG4591	ABC-type transport system involved in lipoprotein release permease component
A3K93_08265	COG0697	spore germination
A3K93_08270	COG1671	Belongs to the UPF0178 family
A3K93_08290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3K93_08335	COG1280	lysine exporter protein (LysE YggA)
A3K93_08350	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A3K93_08360	COG0019	diaminopimelate decarboxylase activity
A3K93_08370	COG1113	amino acid transport
A3K93_08375	COG1115	amino acid carrier protein
A3K93_08405	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A3K93_08410	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A3K93_08415	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A3K93_08440	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A3K93_08460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A3K93_08475	COG0037	tRNA processing
A3K93_08480	COG0741	lytic transglycosylase activity
A3K93_08480	COG0739	heme binding
A3K93_08480	COG1196	nuclear chromosome segregation
A3K93_08490	COG3385	transposase activity
A3K93_08510	COG2239	Acts as a magnesium transporter
A3K93_08530	COG1253	flavin adenine dinucleotide binding
A3K93_08560	COG3385	transposase activity
A3K93_08570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A3K93_08580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A3K93_08585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3K93_08610	COG0505	Belongs to the CarA family
A3K93_08625	COG0110	maltose O-acetyltransferase activity
A3K93_08645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3K93_08670	COG0564	pseudouridine synthase activity
A3K93_08680	COG0358	DNA primase activity
A3K93_08695	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A3K93_08725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A3K93_08730	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A3K93_08745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A3K93_08770	COG0586	Pfam SNARE associated Golgi protein
A3K93_08795	COG0321	lipoyl(octanoyl) transferase activity
A3K93_08810	COG0531	amino acid
A3K93_08820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A3K93_08825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A3K93_08825	COG1648	precorrin-2 dehydrogenase activity
A3K93_08830	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A3K93_08840	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A3K93_08865	COG0671	phosphoesterase, PA-phosphatase related
A3K93_08870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3K93_08880	COG1538	Outer membrane efflux protein
A3K93_08885	COG0393	Putative heavy-metal-binding
A3K93_08890	COG0393	Putative heavy-metal-binding
A3K93_08895	COG0242	peptide deformylase activity
A3K93_08930	COG4681	YaeQ
A3K93_08935	COG0523	cobalamin synthesis protein
A3K93_08950	COG0583	DNA-binding transcription factor activity
A3K93_08955	COG1607	acyl-coa hydrolase
A3K93_08960	COG1752	Esterase of the alpha-beta hydrolase superfamily
A3K93_08965	COG1115	amino acid carrier protein
A3K93_08970	COG0786	glutamate:sodium symporter activity
A3K93_08975	COG2814	Major facilitator Superfamily
A3K93_08980	COG1289	transmembrane transporter activity
A3K93_08990	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A3K93_09050	COG2832	Protein of unknown function (DUF454)
A3K93_09065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3K93_09080	COG0840	transmembrane signaling receptor activity
A3K93_09115	COG0442	prolyl-tRNA aminoacylation
A3K93_09145	COG0489	protein tyrosine kinase activity
A3K93_09160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3K93_09160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3K93_09200	COG2081	HI0933 family
A3K93_09205	COG0668	transmembrane transport
A3K93_09225	COG0583	DNA-binding transcription factor activity
A3K93_09245	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3K93_09250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3K93_09255	COG0713	ATP synthesis coupled electron transport
A3K93_09265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3K93_09280	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A3K93_09290	COG0649	NAD binding
A3K93_09290	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3K93_09310	COG2205	protein histidine kinase activity
A3K93_09315	COG0745	RESPONSE REGULATOR receiver
A3K93_09325	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A3K93_09340	COG1309	transcriptional regulator
A3K93_09350	COG4772	TonB-dependent receptor
A3K93_09365	COG3385	transposase activity
A3K93_09395	COG2824	Alkylphosphonate utilization operon protein PhnA
A3K93_09460	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A3K93_09490	COG1902	pentaerythritol trinitrate reductase activity
A3K93_09510	COG3385	transposase activity
A3K93_09525	COG2233	PERMEase
A3K93_09535	COG0833	amino acid
A3K93_09545	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A3K93_09545	COG2885	chlorophyll binding
A3K93_09555	COG0183	Belongs to the thiolase family
A3K93_09565	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A3K93_09575	COG2207	Transcriptional regulator
A3K93_09580	COG0183	Belongs to the thiolase family
A3K93_09585	COG1024	Enoyl-CoA hydratase
A3K93_09585	COG1250	3-hydroxyacyl-CoA dehydrogenase
A3K93_09605	COG1272	protein, Hemolysin III
A3K93_09610	COG0477	Major facilitator Superfamily
A3K93_09625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A3K93_09635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A3K93_09660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A3K93_09665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A3K93_09675	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A3K93_09680	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A3K93_09695	COG0625	glutathione transferase activity
A3K93_09700	COG2969	positive regulation of protein catabolic process
A3K93_09760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A3K93_09765	COG1764	response to oxidative stress
A3K93_09805	COG0037	tRNA processing
A3K93_09840	COG0072	phenylalanine-tRNA ligase activity
A3K93_09845	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A3K93_09865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A3K93_09885	COG1238	metal cluster binding
A3K93_09895	COG0625	glutathione transferase activity
A3K93_09935	COG0318	PFAM AMP-dependent synthetase and ligase
A3K93_09940	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A3K93_09955	COG1704	LemA family
A3K93_09970	COG1862	Preprotein translocase
A3K93_09990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A3K93_10010	COG0784	Response regulator, receiver
A3K93_10010	COG2205	protein histidine kinase activity
A3K93_10010	COG5002	protein histidine kinase activity
A3K93_10015	COG1024	Enoyl-CoA hydratase
A3K93_10020	COG2084	Dehydrogenase
A3K93_10025	COG3622	Belongs to the hyi family
A3K93_10040	COG0004	ammonium transporteR
A3K93_10045	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A3K93_10050	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A3K93_10055	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A3K93_10060	COG2814	Major facilitator Superfamily
A3K93_10065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A3K93_10075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A3K93_10080	COG2003	Belongs to the UPF0758 family
A3K93_10085	COG3781	membrane
A3K93_10105	COG2350	Protein conserved in bacteria
A3K93_10135	COG1607	acyl-coa hydrolase
A3K93_10150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3K93_10150	COG3453	Protein conserved in bacteria
A3K93_10160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3K93_10200	COG1183	phosphatidylcholine synthase activity
A3K93_10205	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A3K93_10220	COG3385	transposase activity
A3K93_10245	COG0741	lytic transglycosylase activity
A3K93_10245	COG0739	heme binding
A3K93_10245	COG1196	nuclear chromosome segregation
A3K93_10250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3K93_10255	COG1702	phosphate starvation-inducible protein PhoH
A3K93_10260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A3K93_10305	COG1295	ribonuclease BN
A3K93_10315	COG0179	Fumarylacetoacetate (FAA) hydrolase
A3K93_10350	COG0557	exoribonuclease II activity
A3K93_10360	COG0339	signal peptide processing
A3K93_10365	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A3K93_10400	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A3K93_10405	COG1960	acyl-CoA dehydrogenase activity
A3K93_10410	COG2072	flavoprotein involved in K transport
A3K93_10415	COG0203	ribosomal protein L17
A3K93_10420	COG0202	RNA polymerase activity
A3K93_10425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A3K93_10430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A3K93_10435	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A3K93_10440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A3K93_10460	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A3K93_10470	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A3K93_10475	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A3K93_10495	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A3K93_10525	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A3K93_10540	COG0088	Forms part of the polypeptide exit tunnel
A3K93_10545	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A3K93_10560	COG0626	cystathionine gamma-synthase activity
A3K93_10565	COG0433	COG0433 Predicted ATPase
A3K93_10570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A3K93_10570	COG1017	nitric oxide dioxygenase activity
A3K93_10575	COG1959	2 iron, 2 sulfur cluster binding
A3K93_10590	COG1301	dicarboxylic acid transport
A3K93_10595	COG1946	Acyl-CoA thioesterase
A3K93_10600	COG2937	Belongs to the GPAT DAPAT family
A3K93_10610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A3K93_10615	COG1040	competence protein
A3K93_10630	COG0598	Magnesium transport protein CorA
A3K93_10640	COG2854	intermembrane phospholipid transfer
A3K93_10650	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A3K93_10655	COG1127	ABC transporter
A3K93_10660	COG0513	Belongs to the DEAD box helicase family
A3K93_10680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A3K93_10700	COG1960	acyl-CoA dehydrogenase activity
A3K93_10710	COG1278	Cold shock
A3K93_10720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A3K93_10730	COG0534	Mate efflux family protein
A3K93_10740	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A3K93_10745	COG0254	rRNA binding
A3K93_10750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A3K93_10765	COG2226	methyltransferase
A3K93_10780	COG1192	Involved in chromosome partitioning
A3K93_10785	COG0628	permease
A3K93_10790	COG2032	superoxide dismutase activity
A3K93_10795	COG2814	Major facilitator Superfamily
A3K93_10815	COG0277	FAD linked oxidase domain protein
A3K93_10820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A3K93_10825	COG5006	permease, DMT superfamily
A3K93_10830	COG5006	permease, DMT superfamily
A3K93_10845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A3K93_10850	COG5380	lipid catabolic process
A3K93_10855	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A3K93_10865	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A3K93_10870	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A3K93_10900	COG0335	large ribosomal subunit rRNA binding
A3K93_10910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A3K93_10915	COG0228	four-way junction DNA binding
A3K93_10920	COG0675	Transposase, IS605 OrfB family
A3K93_10960	COG0194	GDP metabolic process
A3K93_10965	COG1758	RNA polymerase activity
A3K93_10970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A3K93_10980	COG2906	2 iron, 2 sulfur cluster binding
A3K93_10990	COG3307	-O-antigen
A3K93_11015	COG2801	Transposase and inactivated derivatives
A3K93_11025	COG2755	lipolytic protein G-D-S-L family
A3K93_11025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A3K93_11030	COG2963	transposase activity
A3K93_11070	COG0297	glycogen (starch) synthase activity
A3K93_11080	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A3K93_11090	COG3475	LICD family
A3K93_11115	COG1132	(ABC) transporter
A3K93_11150	COG1704	LemA family
A3K93_11160	COG0493	'glutamate synthase
A3K93_11165	COG0070	glutamate synthase
A3K93_11165	COG0069	glutamate synthase activity
A3K93_11165	COG0067	glutamate synthase
A3K93_11215	COG2226	methyltransferase
A3K93_11225	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A3K93_11230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A3K93_11245	COG0275	rRNA processing
A3K93_11265	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A3K93_11295	COG0488	(ABC) transporter
A3K93_11305	COG4221	oxidoreductase activity
A3K93_11310	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A3K93_11320	COG0675	Transposase, IS605 OrfB family
A3K93_11335	COG2111	Na H antiporter
A3K93_11335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3K93_11340	COG1006	Multisubunit Na H antiporter MnhC subunit
A3K93_11345	COG0651	ATP synthesis coupled electron transport
A3K93_11350	COG1863	multisubunit Na H antiporter MnhE subunit
A3K93_11355	COG2212	antiporter activity
A3K93_11365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A3K93_11375	COG0195	Participates in both transcription termination and antitermination
A3K93_11410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A3K93_11415	COG0149	triose-phosphate isomerase activity
A3K93_11435	COG0237	dephospho-CoA kinase activity
A3K93_11440	COG0697	spore germination
A3K93_11445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A3K93_11450	COG3123	guanosine phosphorylase activity
A3K93_11455	COG0497	DNA recombination
A3K93_11465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A3K93_11480	COG1289	transmembrane transporter activity
A3K93_11495	COG1132	(ABC) transporter
A3K93_11505	COG1538	Outer membrane efflux protein
A3K93_11520	COG0494	nUDIX hydrolase
A3K93_11530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A3K93_11535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A3K93_11545	COG0772	Belongs to the SEDS family
A3K93_11570	COG4974	Belongs to the 'phage' integrase family
A3K93_11575	COG0675	Transposase, IS605 OrfB family
A3K93_11585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A3K93_11595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A3K93_11600	COG1686	Belongs to the peptidase S11 family
A3K93_11605	COG2197	response regulator
A3K93_11610	COG3852	Histidine kinase
A3K93_11620	COG0793	Belongs to the peptidase S41A family
A3K93_11625	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A3K93_11630	COG0795	lipopolysaccharide-transporting ATPase activity
A3K93_11635	COG0795	lipopolysaccharide-transporting ATPase activity
A3K93_11655	COG0586	Pfam SNARE associated Golgi protein
A3K93_11670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A3K93_11670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A3K93_11680	COG0004	ammonium transporteR
A3K93_11685	COG0347	Belongs to the P(II) protein family
A3K93_11695	COG0606	chelatase, subunit chli
A3K93_11710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A3K93_11725	COG0318	PFAM AMP-dependent synthetase and ligase
A3K93_11735	COG0477	Major facilitator Superfamily
A3K93_11740	COG2860	membrane
A3K93_11750	COG1253	flavin adenine dinucleotide binding
A3K93_11775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A3K93_11780	COG0477	Major facilitator Superfamily
A3K93_11845	COG0758	DNA mediated transformation
A3K93_11855	COG0697	spore germination
A3K93_11860	COG0386	Belongs to the glutathione peroxidase family
A3K93_11900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A3K93_11945	COG0735	belongs to the Fur family
A3K93_11950	COG1121	(ABC) transporter
A3K93_11955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A3K93_11960	COG1683	Conserved Protein
A3K93_11965	COG0668	transmembrane transport
A3K93_11975	COG2837	iron assimilation
A3K93_11980	COG0436	Aminotransferase
A3K93_11985	COG0534	Mate efflux family protein
A3K93_12035	COG3706	GGDEF domain
A3K93_12060	COG0519	Catalyzes the synthesis of GMP from XMP
A3K93_12060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A3K93_12070	COG2259	Doxx family
A3K93_12075	COG0586	Pfam SNARE associated Golgi protein
A3K93_12090	COG1192	Involved in chromosome partitioning
A3K93_12100	COG0271	Belongs to the BolA IbaG family
A3K93_12140	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A3K93_12145	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A3K93_12155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A3K93_12185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3K93_12190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A3K93_12205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A3K93_12245	COG1088	dTDP-glucose 4,6-dehydratase activity
A3K93_12255	COG1215	transferase activity, transferring glycosyl groups
A3K93_12255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A3K93_12295	COG4372	Transposase
A3K93_12315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A3K93_12325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A3K93_12330	COG0438	transferase activity, transferring glycosyl groups
A3K93_12335	COG0438	transferase activity, transferring glycosyl groups
A3K93_12340	COG0438	transferase activity, transferring glycosyl groups
A3K93_12365	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A3K93_12410	COG0739	heme binding
A3K93_12420	COG2818	Glycosylase
A3K93_12425	COG1064	alcohol dehydrogenase
A3K93_12430	COG1725	Transcriptional regulator
A3K93_12445	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A3K93_12470	COG1309	transcriptional regulator
A3K93_12480	COG2233	PERMEase
A3K93_12505	COG0129	dihydroxy-acid dehydratase activity
A3K93_12515	COG0129	dihydroxy-acid dehydratase activity
A3K93_12525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3K93_12525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3K93_12530	COG0733	neurotransmitter:sodium symporter activity
A3K93_12535	COG0693	protein deglycase activity
A3K93_12550	COG2814	Major facilitator Superfamily
A3K93_12580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A3K93_12645	COG0488	(ABC) transporter
A3K93_12650	COG1063	alcohol dehydrogenase
A3K93_12660	COG0187	DNA topoisomerase II activity
A3K93_12670	COG0592	DNA-directed DNA polymerase activity
A3K93_12675	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A3K93_12680	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A3K93_12685	COG0594	ribonuclease P activity
A3K93_12690	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A3K93_12695	COG0706	membrane insertase activity
A3K93_12725	COG0402	S-adenosylhomocysteine deaminase activity
A3K93_12730	COG0861	Integral membrane protein TerC family
A3K93_12740	COG2388	GCN5-related N-acetyl-transferase
A3K93_12750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A3K93_12770	COG0675	Transposase, IS605 OrfB family
A3K93_12785	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A3K93_12795	COG2951	lytic endotransglycosylase activity
A3K93_12800	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A3K93_12805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A3K93_12845	COG5001	Diguanylate cyclase
A3K93_12845	COG2203	Gaf domain
A3K93_12845	COG3706	GGDEF domain
A3K93_12845	COG4251	negative regulation of phosphorylation
A3K93_12850	COG2133	pyrroloquinoline quinone binding
A3K93_12860	COG1047	Peptidyl-prolyl cis-trans
A3K93_12865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A3K93_12870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A3K93_12875	COG0196	riboflavin kinase activity
A3K93_12885	COG1309	transcriptional regulator
A3K93_12895	COG1116	anion transmembrane transporter activity
A3K93_12900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3K93_12905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A3K93_12910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3K93_12915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3K93_12940	COG1028	Short-chain dehydrogenase reductase Sdr
A3K93_12945	COG0546	phosphoglycolate phosphatase activity
A3K93_12950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A3K93_12965	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A3K93_12975	COG3023	N-Acetylmuramoyl-L-alanine amidase
A3K93_12985	COG2983	Belongs to the UPF0260 family
A3K93_12995	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A3K93_13000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A3K93_13010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3K93_13015	COG2814	Major facilitator Superfamily
A3K93_13020	COG1335	isochorismatase
A3K93_13025	COG0385	Bile acid
A3K93_13035	COG3830	Belongs to the UPF0237 family
A3K93_13035	COG0560	Phosphoserine phosphatase
A3K93_13060	COG0753	catalase activity
A3K93_13105	COG2733	membrane
A3K93_13120	COG2918	glutathione biosynthetic process
A3K93_13130	COG3385	transposase activity
A3K93_13140	COG3150	esterase
A3K93_13165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A3K93_13170	COG0410	ABC transporter
A3K93_13195	COG3733	amine oxidase
A3K93_13210	COG0183	Belongs to the thiolase family
A3K93_13215	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A3K93_13230	COG0625	glutathione transferase activity
A3K93_13260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3K93_13280	COG4771	TonB-dependent receptor
A3K93_13290	COG0667	Aldo Keto reductase
A3K93_13305	COG4974	Belongs to the 'phage' integrase family
A3K93_13340	COG1401	restriction endodeoxyribonuclease activity
A3K93_13360	COG2175	clavaminate synthase activity
A3K93_13365	COG1484	DNA-dependent DNA replication
A3K93_13370	COG2390	Transcriptional regulator
A3K93_13370	COG4584	PFAM Integrase catalytic
A3K93_13400	COG2801	Transposase and inactivated derivatives
A3K93_13415	COG1132	(ABC) transporter
A3K93_13435	COG3842	ATPase activity
A3K93_13475	COG0675	Transposase, IS605 OrfB family
A3K93_13485	COG1309	transcriptional regulator
A3K93_13495	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A3K93_13500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3K93_13505	COG0583	DNA-binding transcription factor activity
A3K93_13520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A3K93_13535	COG4372	Transposase
A3K93_13540	COG1113	amino acid transport
A3K93_13550	COG1271	oxidase subunit
A3K93_13555	COG1294	oxidase, subunit
A3K93_13575	COG1953	Uracil, thiamine, allantoin
A3K93_13595	COG0675	Transposase, IS605 OrfB family
A3K93_13605	COG2351	hydroxyisourate hydrolase activity
A3K93_13620	COG0675	Transposase, IS605 OrfB family
A3K93_13640	COG4266	Belongs to the allantoicase family
A3K93_13645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A3K93_13655	COG0583	DNA-binding transcription factor activity
A3K93_13690	COG0402	S-adenosylhomocysteine deaminase activity
A3K93_13720	COG1120	ATPase activity
A3K93_13755	COG2072	flavoprotein involved in K transport
A3K93_13760	COG0640	Transcriptional regulator
A3K93_13795	COG4372	Transposase
A3K93_13835	COG3077	Addiction module antitoxin, RelB DinJ family
A3K93_13845	COG0640	Transcriptional regulator
A3K93_13850	COG0798	PFAM Bile acid sodium symporter
A3K93_13855	COG0431	NADPH-dependent FMN reductase
A3K93_13865	COG3077	Addiction module antitoxin, RelB DinJ family
A3K93_13870	COG2318	DinB family
A3K93_13920	COG3077	Addiction module antitoxin, RelB DinJ family
A3K93_13930	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A3K93_13935	COG3657	addiction module killer protein
A3K93_13945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A3K93_13955	COG2072	flavoprotein involved in K transport
A3K93_13965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3K93_13980	COG1012	belongs to the aldehyde dehydrogenase family
A3K93_13985	COG1309	transcriptional regulator
A3K93_13990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A3K93_14010	COG4774	siderophore transport
A3K93_14025	COG0675	Transposase, IS605 OrfB family
A3K93_14035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3K93_14040	COG1116	anion transmembrane transporter activity
A3K93_14070	COG0864	Transcriptional regulator
A3K93_14075	COG2026	Addiction module toxin, RelE StbE family
A3K93_14090	COG0439	Biotin carboxylase
A3K93_14120	COG1192	Involved in chromosome partitioning
A3K93_14125	COG1475	DNA binding
A3K93_14150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A3K93_14155	COG0183	Belongs to the thiolase family
A3K93_14160	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A3K93_14165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A3K93_14175	COG4829	muconolactone delta-isomerase
A3K93_14180	COG4948	Mandelate Racemase Muconate Lactonizing
A3K93_14185	COG0583	DNA-binding transcription factor activity
A3K93_14195	COG0154	amidase activity
A3K93_14215	COG4638	Rieske (2fe-2S)
A3K93_14225	COG1028	Short-chain dehydrogenase reductase Sdr
A3K93_14235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3K93_14255	COG0411	ABC transporter
A3K93_14265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A3K93_14280	COG2207	Transcriptional regulator
A3K93_14290	COG1012	belongs to the aldehyde dehydrogenase family
A3K93_14295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A3K93_14300	COG3850	Histidine kinase
A3K93_14305	COG2197	response regulator
A3K93_14325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A3K93_14365	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A3K93_14380	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3K93_14380	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A3K93_14390	COG2826	transposase and inactivated derivatives, IS30 family
A3K93_14395	COG0004	ammonium transporteR
A3K93_14400	COG1396	sequence-specific DNA binding
A3K93_14410	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A3K93_14415	COG2218	PFAM glutamate synthase alpha subunit domain protein
A3K93_14420	COG0069	glutamate synthase activity
A3K93_14430	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A3K93_14435	COG0830	nickel cation binding
A3K93_14440	COG0832	Belongs to the urease beta subunit family
A3K93_14440	COG0831	urea catabolic process
A3K93_14445	COG0804	urea catabolic process
A3K93_14450	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A3K93_14455	COG0829	nickel cation binding
A3K93_14460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3K93_14460	COG1116	anion transmembrane transporter activity
A3K93_14470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A3K93_14475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A3K93_14480	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
A3K93_14495	COG2116	formate transmembrane transporter activity
A3K93_14505	COG0582	viral genome integration into host DNA
A3K93_14525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3K93_14530	COG2197	response regulator
A3K93_14555	COG0477	Major facilitator Superfamily
A3K93_14565	COG0675	Transposase, IS605 OrfB family