locus-tag	class	description
HGD77_00025	COG1194	a g-specific adenine glycosylase
HGD77_00030	COG0739	heme binding
HGD77_00040	COG2818	Glycosylase
HGD77_00045	COG1064	alcohol dehydrogenase
HGD77_00050	COG0675	Transposase, IS605 OrfB family
HGD77_00065	COG4372	Transposase
HGD77_00105	COG0675	Transposase, IS605 OrfB family
HGD77_00145	COG2233	PERMEase
HGD77_00165	COG0675	Transposase, IS605 OrfB family
HGD77_00170	COG0129	dihydroxy-acid dehydratase activity
HGD77_00175	COG0129	dihydroxy-acid dehydratase activity
HGD77_00185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HGD77_00190	COG0428	transporter
HGD77_00200	COG0733	neurotransmitter:sodium symporter activity
HGD77_00205	COG1012	belongs to the aldehyde dehydrogenase family
HGD77_00215	COG0693	protein deglycase activity
HGD77_00230	COG2814	Major facilitator Superfamily
HGD77_00245	COG2814	Major facilitator Superfamily
HGD77_00275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HGD77_00340	COG0488	(ABC) transporter
HGD77_00345	COG1063	alcohol dehydrogenase
HGD77_00350	COG0187	DNA topoisomerase II activity
HGD77_00360	COG0592	DNA-directed DNA polymerase activity
HGD77_00365	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HGD77_00375	COG0594	ribonuclease P activity
HGD77_00380	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HGD77_00385	COG0706	membrane insertase activity
HGD77_00395	COG3385	transposase activity
HGD77_00420	COG0402	S-adenosylhomocysteine deaminase activity
HGD77_00430	COG0861	Integral membrane protein TerC family
HGD77_00440	COG2388	GCN5-related N-acetyl-transferase
HGD77_00465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HGD77_00485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HGD77_00490	COG2951	lytic endotransglycosylase activity
HGD77_00495	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HGD77_00500	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HGD77_00535	COG2133	pyrroloquinoline quinone binding
HGD77_00550	COG1047	Peptidyl-prolyl cis-trans
HGD77_00555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HGD77_00560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HGD77_00565	COG0196	riboflavin kinase activity
HGD77_00575	COG1309	transcriptional regulator
HGD77_00580	COG1116	anion transmembrane transporter activity
HGD77_00585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGD77_00590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGD77_00595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HGD77_00600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HGD77_00605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HGD77_00605	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HGD77_00630	COG1028	Short-chain dehydrogenase reductase Sdr
HGD77_00635	COG0546	phosphoglycolate phosphatase activity
HGD77_00640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HGD77_00645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HGD77_00655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HGD77_00670	COG3023	N-Acetylmuramoyl-L-alanine amidase
HGD77_00675	COG0728	peptidoglycan biosynthetic process
HGD77_00680	COG5487	UPF0391 membrane protein
HGD77_00685	COG2983	Belongs to the UPF0260 family
HGD77_00690	COG3300	MHYT domain
HGD77_00690	COG5001	Diguanylate cyclase
HGD77_00695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HGD77_00700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HGD77_00710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGD77_00715	COG2814	Major facilitator Superfamily
HGD77_00720	COG1335	isochorismatase
HGD77_00725	COG0385	Bile acid
HGD77_00765	COG0753	catalase activity
HGD77_00805	COG2733	membrane
HGD77_00820	COG2918	glutathione biosynthetic process
HGD77_00825	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HGD77_00840	COG3150	esterase
HGD77_00890	COG1247	-acetyltransferase
HGD77_00920	COG3706	GGDEF domain
HGD77_00945	COG0708	Exodeoxyribonuclease III
HGD77_00950	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HGD77_00955	COG1278	Cold shock
HGD77_00970	COG2132	Multicopper oxidase
HGD77_00985	COG0189	ligase activity
HGD77_01000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HGD77_01010	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HGD77_01045	COG0508	dehydrogenase complex catalyzes the overall conversion of
HGD77_01050	COG2119	membrane
HGD77_01055	COG0426	domain, Protein
HGD77_01055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HGD77_01080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HGD77_01105	COG1902	pentaerythritol trinitrate reductase activity
HGD77_01110	COG1519	Transferase
HGD77_01115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HGD77_01120	COG0668	transmembrane transport
HGD77_01125	COG3152	Membrane
HGD77_01130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HGD77_01145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGD77_01150	COG0431	NADPH-dependent FMN reductase
HGD77_01165	COG2205	protein histidine kinase activity
HGD77_01165	COG0784	Response regulator, receiver
HGD77_01170	COG3162	membrane
HGD77_01195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HGD77_01205	COG3706	GGDEF domain
HGD77_01225	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HGD77_01225	COG0352	thiamine-phosphate diphosphorylase activity
HGD77_01225	COG0351	phosphomethylpyrimidine kinase
HGD77_01235	COG2814	Major facilitator Superfamily
HGD77_01270	COG0641	radical SAM
HGD77_01320	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HGD77_01395	COG0582	viral genome integration into host DNA
HGD77_01405	COG3158	transport of potassium into the cell
HGD77_01445	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HGD77_01490	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HGD77_01560	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGD77_01560	COG1024	Enoyl-CoA hydratase
HGD77_01585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGD77_01620	COG0181	hydroxymethylbilane synthase activity
HGD77_01670	COG0546	phosphoglycolate phosphatase activity
HGD77_01700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HGD77_01725	COG0081	regulation of translation
HGD77_01730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HGD77_01735	COG0222	ribosome binding
HGD77_01740	COG0085	RNA polymerase activity
HGD77_01745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HGD77_01765	COG2056	Na+-H+ antiporter family
HGD77_01770	COG3047	cAMP biosynthetic process
HGD77_01780	COG0326	Molecular chaperone. Has ATPase activity
HGD77_01815	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HGD77_01820	COG0427	acetyl-CoA hydrolase
HGD77_01825	COG2205	protein histidine kinase activity
HGD77_01830	COG0745	RESPONSE REGULATOR receiver
HGD77_01855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HGD77_01885	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HGD77_01890	COG1074	ATP-dependent DNA helicase activity
HGD77_01895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HGD77_01900	COG3293	Transposase
HGD77_01905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HGD77_01910	COG1185	polyribonucleotide nucleotidyltransferase activity
HGD77_01915	COG2841	Protein conserved in bacteria
HGD77_01920	COG0789	Transcriptional regulator
HGD77_01930	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HGD77_01935	COG0475	glutathione-regulated potassium exporter activity
HGD77_01935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HGD77_01940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HGD77_01960	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HGD77_01965	COG4535	Mg2 and Co2 transporter CorC
HGD77_01970	COG0425	Belongs to the sulfur carrier protein TusA family
HGD77_01975	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HGD77_01975	COG0644	oxidoreductase
HGD77_01985	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HGD77_02000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGD77_02010	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HGD77_02020	COG0493	'glutamate synthase
HGD77_02045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGD77_02065	COG0751	glycine-tRNA ligase activity
HGD77_02095	COG0471	metal ion transport
HGD77_02110	COG1983	PspC domain protein
HGD77_02135	COG0318	PFAM AMP-dependent synthetase and ligase
HGD77_02140	COG1530	ribonuclease E activity
HGD77_02145	COG0564	pseudouridine synthase activity
HGD77_02150	COG0546	phosphoglycolate phosphatase activity
HGD77_02155	COG2826	transposase and inactivated derivatives, IS30 family
HGD77_02160	COG3971	2-oxopent-4-enoate hydratase activity
HGD77_02165	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HGD77_02195	COG0583	DNA-binding transcription factor activity
HGD77_02210	COG4638	Rieske (2fe-2S)
HGD77_02225	COG1028	Short-chain dehydrogenase reductase Sdr
HGD77_02230	COG3384	dioxygenase
HGD77_02235	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGD77_02255	COG3011	Protein conserved in bacteria
HGD77_02260	COG0753	catalase activity
HGD77_02300	COG0583	DNA-binding transcription factor activity
HGD77_02310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HGD77_02325	COG0473	3-isopropylmalate dehydrogenase activity
HGD77_02385	COG1560	Kdo2-lipid A biosynthetic process
HGD77_02395	COG2900	Belongs to the SlyX family
HGD77_02430	COG1929	Belongs to the glycerate kinase type-1 family
HGD77_02435	COG0210	DNA helicase
HGD77_02455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HGD77_02455	COG4651	solute:proton antiporter activity
HGD77_02480	COG0788	formyltetrahydrofolate deformylase activity
HGD77_02525	COG3040	lipid binding
HGD77_02590	COG2813	Specifically methylates the guanine in position
HGD77_02590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HGD77_02595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HGD77_02600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HGD77_02610	COG4774	siderophore transport
HGD77_02615	COG4771	TonB-dependent receptor
HGD77_02625	COG0740	serine-type endopeptidase activity
HGD77_02640	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HGD77_02640	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HGD77_02650	COG0857	belongs to the CobB CobQ family
HGD77_02650	COG0280	phosphate acetyltransferase
HGD77_02655	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HGD77_02680	COG0793	Belongs to the peptidase S41A family
HGD77_02690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HGD77_02705	COG0084	hydrolase, TatD family'
HGD77_02730	COG1162	GTPase activity
HGD77_02735	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HGD77_02745	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HGD77_02755	COG1538	Outer membrane efflux protein
HGD77_02760	COG0577	efflux transmembrane transporter activity
HGD77_02760	COG1136	(ABC) transporter
HGD77_02765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGD77_02790	COG0028	Belongs to the TPP enzyme family
HGD77_02795	COG0440	acetolactate synthase activity
HGD77_02800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HGD77_02830	COG2826	transposase and inactivated derivatives, IS30 family
HGD77_02860	COG2826	transposase and inactivated derivatives, IS30 family
HGD77_02875	COG2826	transposase and inactivated derivatives, IS30 family
HGD77_02895	COG2975	iron-sulfur cluster assembly
HGD77_02915	COG1426	Protein conserved in bacteria
HGD77_02935	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGD77_02950	COG0300	oxidoreductase activity
HGD77_02955	COG3956	TIGRFAM MazG family protein
HGD77_02960	COG1555	photosystem II stabilization
HGD77_02965	COG0617	tRNA 3'-terminal CCA addition
HGD77_02970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HGD77_02985	COG1660	Displays ATPase and GTPase activities
HGD77_02990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGD77_03000	COG2205	protein histidine kinase activity
HGD77_03005	COG0675	Transposase, IS605 OrfB family
HGD77_03010	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HGD77_03065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HGD77_03105	COG1960	acyl-CoA dehydrogenase activity
HGD77_03110	COG1960	acyl-CoA dehydrogenase activity
HGD77_03120	COG2205	protein histidine kinase activity
HGD77_03125	COG0745	RESPONSE REGULATOR receiver
HGD77_03150	COG2096	Adenosyltransferase
HGD77_03155	COG4206	TonB-dependent receptor
HGD77_03170	COG0318	PFAM AMP-dependent synthetase and ligase
HGD77_03190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HGD77_03205	COG0625	glutathione transferase activity
HGD77_03215	COG1238	metal cluster binding
HGD77_03245	COG0072	phenylalanine-tRNA ligase activity
HGD77_03270	COG0248	Ppx GppA phosphatase
HGD77_03280	COG0037	tRNA processing
HGD77_03335	COG2433	Pfam Transposase IS66
HGD77_03345	COG1764	response to oxidative stress
HGD77_03350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HGD77_03415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HGD77_03420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HGD77_03470	COG0494	nUDIX hydrolase
HGD77_03480	COG1214	PFAM Peptidase M22, glycoprotease
HGD77_03485	COG1968	undecaprenyl-diphosphatase activity
HGD77_03505	COG4269	membrane
HGD77_03520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HGD77_03530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HGD77_03545	COG2814	Major facilitator Superfamily
HGD77_03550	COG1012	belongs to the aldehyde dehydrogenase family
HGD77_03550	COG2030	dehydratase
HGD77_03555	COG3396	Phenylacetate-CoA oxygenase
HGD77_03560	COG3460	Phenylacetate-CoA oxygenase
HGD77_03565	COG3396	Phenylacetate-CoA oxygenase
HGD77_03570	COG2151	metal-sulfur cluster biosynthetic enzyme
HGD77_03575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HGD77_03580	COG1024	Enoyl-CoA hydratase
HGD77_03585	COG1024	Enoyl-CoA hydratase
HGD77_03590	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGD77_03595	COG0183	Belongs to the thiolase family
HGD77_03600	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HGD77_03605	COG3327	negative regulation of DNA-templated transcription, initiation
HGD77_03615	COG4106	trans-aconitate 2-methyltransferase activity
HGD77_03625	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HGD77_03650	COG0730	response to heat
HGD77_03660	COG1196	nuclear chromosome segregation
HGD77_03670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HGD77_03680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGD77_03685	COG2193	ferroxidase activity
HGD77_03755	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HGD77_03760	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HGD77_03775	COG0009	L-threonylcarbamoyladenylate synthase
HGD77_03780	COG3101	peptidyl-lysine hydroxylation
HGD77_03785	COG1399	metal-binding, possibly nucleic acid-binding protein
HGD77_03795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HGD77_03800	COG1028	Short-chain dehydrogenase reductase Sdr
HGD77_03805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HGD77_03810	COG1652	LysM domain
HGD77_03830	COG0251	oxidation-reduction process
HGD77_03835	COG1113	amino acid transport
HGD77_03855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HGD77_03870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HGD77_03880	COG0456	acetyltransferase
HGD77_03890	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HGD77_03895	COG0492	ferredoxin-NADP+ reductase activity
HGD77_03900	COG1674	ftsk spoiiie
HGD77_03900	COG0531	amino acid
HGD77_03930	COG0204	Acyl-transferase
HGD77_03935	COG2885	chlorophyll binding
HGD77_03940	COG0210	DNA helicase
HGD77_03945	COG0756	dUTP diphosphatase activity
HGD77_03950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGD77_03955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HGD77_03960	COG0121	glutamine amidotransferase
HGD77_03975	COG2914	Belongs to the UPF0125 (RnfH) family
HGD77_03980	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGD77_03985	COG0735	belongs to the Fur family
HGD77_04015	COG0420	3'-5' exonuclease activity
HGD77_04025	COG0702	epimerase
HGD77_04030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGD77_04040	COG2050	protein possibly involved in aromatic compounds catabolism
HGD77_04045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HGD77_04055	COG0582	viral genome integration into host DNA
HGD77_04065	COG2826	transposase and inactivated derivatives, IS30 family
HGD77_04075	COG2826	transposase and inactivated derivatives, IS30 family
HGD77_04080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HGD77_04090	COG3177	Filamentation induced by cAMP protein fic
HGD77_04125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGD77_04130	COG4591	ABC-type transport system involved in lipoprotein release permease component
HGD77_04135	COG1136	(ABC) transporter
HGD77_04140	COG0783	Belongs to the Dps family
HGD77_04165	COG0500	methyltransferase
HGD77_04175	COG2223	nitrite transmembrane transporter activity
HGD77_04180	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HGD77_04215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGD77_04225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGD77_04230	COG1077	Cell shape determining protein MreB Mrl
HGD77_04235	COG1792	Involved in formation and maintenance of cell shape
HGD77_04240	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HGD77_04245	COG0424	maF-like protein
HGD77_04250	COG1530	ribonuclease E activity
HGD77_04270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HGD77_04305	COG1113	amino acid transport
HGD77_04310	COG2828	Protein conserved in bacteria
HGD77_04315	COG0142	geranyltranstransferase activity
HGD77_04320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HGD77_04335	COG1752	Esterase of the alpha-beta hydrolase superfamily
HGD77_04360	COG3335	DDE superfamily endonuclease
HGD77_04375	COG2323	membrane
HGD77_04410	COG0525	valine-tRNA ligase activity
HGD77_04420	COG1028	Short-chain dehydrogenase reductase Sdr
HGD77_04430	COG2066	Belongs to the glutaminase family
HGD77_04450	COG0306	phosphate transporter
HGD77_04475	COG4771	TonB-dependent receptor
HGD77_04500	COG4181	ATPase activity
HGD77_04505	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HGD77_04515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HGD77_04530	COG0583	DNA-binding transcription factor activity
HGD77_04535	COG2267	carboxylic ester hydrolase activity
HGD77_04540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HGD77_04545	COG1773	rubredoxin
HGD77_04550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HGD77_04570	COG2354	Protein conserved in bacteria
HGD77_04575	COG2321	neutral zinc metallopeptidase
HGD77_04600	COG0589	response to stress
HGD77_04635	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HGD77_04640	COG1053	succinate dehydrogenase
HGD77_04645	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HGD77_04660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HGD77_04670	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HGD77_04675	COG3385	transposase activity
HGD77_04680	COG2268	Band 7 protein
HGD77_04710	COG3118	belongs to the thioredoxin family
HGD77_04715	COG3321	synthase
HGD77_04715	COG0604	alcohol dehydrogenase
HGD77_04715	COG1028	Short-chain dehydrogenase reductase Sdr
HGD77_04740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HGD77_04760	COG1597	lipid kinase activity
HGD77_04820	COG0742	ribosomal rna small subunit methyltransferase
HGD77_04825	COG0768	penicillin binding
HGD77_04850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HGD77_04855	COG2878	Part of a membrane complex involved in electron transport
HGD77_04860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HGD77_04870	COG3384	dioxygenase
HGD77_04880	COG2234	aminopeptidase activity
HGD77_04890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HGD77_04915	COG1802	Transcriptional regulator
HGD77_04950	COG0006	proline dipeptidase activity
HGD77_04955	COG2155	Conserved Protein
HGD77_04965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGD77_04970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGD77_04985	COG3107	peptidoglycan biosynthetic process
HGD77_05025	COG0741	lytic transglycosylase activity
HGD77_05025	COG1388	LysM domain
HGD77_05025	COG0741	lytic transglycosylase activity
HGD77_05025	COG1388	LysM domain
HGD77_05030	COG4166	transmembrane transport
HGD77_05035	COG4174	ABC transporter (Permease)
HGD77_05040	COG4239	(ABC) transporter, permease
HGD77_05080	COG0833	amino acid
HGD77_05105	COG0418	dihydroorotase activity
HGD77_05115	COG2203	Gaf domain
HGD77_05115	COG3706	GGDEF domain
HGD77_05115	COG4251	negative regulation of phosphorylation
HGD77_05115	COG5001	Diguanylate cyclase
HGD77_05130	COG1902	pentaerythritol trinitrate reductase activity
HGD77_05130	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGD77_05150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HGD77_05170	COG0582	viral genome integration into host DNA
HGD77_05180	COG1741	Belongs to the pirin family
HGD77_05195	COG3739	integral membrane protein
HGD77_05210	COG3706	GGDEF domain
HGD77_05240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HGD77_05245	COG0512	Glutamine amidotransferase of anthranilate synthase
HGD77_05430	COG0174	glutamine synthetase
HGD77_05445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HGD77_05485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HGD77_05490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HGD77_05495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGD77_05505	COG0596	Alpha beta hydrolase
HGD77_05510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGD77_05515	COG1335	isochorismatase
HGD77_05520	COG0251	oxidation-reduction process
HGD77_05525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HGD77_05530	COG2233	PERMEase
HGD77_05535	COG2084	Dehydrogenase
HGD77_05550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HGD77_05555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HGD77_05565	COG2175	clavaminate synthase activity
HGD77_05590	COG0556	nucleotide-excision repair
HGD77_05615	COG1733	regulation of RNA biosynthetic process
HGD77_05625	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HGD77_05645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HGD77_05650	COG0076	glutamate decarboxylase activity
HGD77_05655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HGD77_05660	COG0573	inorganic phosphate transmembrane transporter activity
HGD77_05670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HGD77_05675	COG0616	signal peptide processing
HGD77_05705	COG0482	sulfurtransferase activity
HGD77_05730	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HGD77_05735	COG1686	Belongs to the peptidase S11 family
HGD77_05750	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HGD77_05760	COG0583	DNA-binding transcription factor activity
HGD77_05765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HGD77_05770	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HGD77_05795	COG0254	rRNA binding
HGD77_05810	COG1509	lysine 2,3-aminomutase activity
HGD77_05815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HGD77_05820	COG1966	Carbon starvation protein
HGD77_05825	COG2879	small protein
HGD77_05835	COG0714	Associated with various cellular activities
HGD77_05850	COG2433	Pfam Transposase IS66
HGD77_05880	COG2203	Gaf domain
HGD77_05880	COG2199	diguanylate cyclase activity
HGD77_05900	COG0640	Transcriptional regulator
HGD77_05910	COG0798	PFAM Bile acid sodium symporter
HGD77_05915	COG0431	NADPH-dependent FMN reductase
HGD77_05920	COG2072	flavoprotein involved in K transport
HGD77_05925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGD77_05935	COG0642	Histidine kinase
HGD77_05950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGD77_05965	COG0640	Transcriptional regulator
HGD77_06000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HGD77_06005	COG1765	OsmC-like protein
HGD77_06015	COG0667	Aldo Keto reductase
HGD77_06040	COG0540	Belongs to the ATCase OTCase family
HGD77_06055	COG2031	fatty acid transporter
HGD77_06060	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HGD77_06075	COG4770	biotin carboxylase activity
HGD77_06080	COG1024	Enoyl-CoA hydratase
HGD77_06085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HGD77_06090	COG1960	acyl-CoA dehydrogenase activity
HGD77_06095	COG1309	transcriptional regulator
HGD77_06100	COG0318	PFAM AMP-dependent synthetase and ligase
HGD77_06120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HGD77_06125	COG0659	secondary active sulfate transmembrane transporter activity
HGD77_06130	COG0625	glutathione transferase activity
HGD77_06145	COG2363	Small membrane protein
HGD77_06160	COG1278	Cold shock
HGD77_06165	COG0513	Belongs to the DEAD box helicase family
HGD77_06175	COG0778	Nitroreductase
HGD77_06200	COG0167	dihydroorotate dehydrogenase activity
HGD77_06215	COG0501	Belongs to the peptidase M48B family
HGD77_06240	COG1610	YqeY-like protein
HGD77_06255	COG2203	Gaf domain
HGD77_06255	COG2199	diguanylate cyclase activity
HGD77_06270	COG4372	Transposase
HGD77_06350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGD77_06365	COG0612	Peptidase, M16
HGD77_06385	COG3025	triphosphatase activity
HGD77_06400	COG0352	thiamine-phosphate diphosphorylase activity
HGD77_06445	COG1309	transcriptional regulator
HGD77_06480	COG2070	2-Nitropropane dioxygenase
HGD77_06500	COG2391	methyltransferase activity
HGD77_06510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HGD77_06520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HGD77_06545	COG0505	Belongs to the CarA family
HGD77_06550	COG0625	glutathione transferase activity
HGD77_06580	COG0517	IMP dehydrogenase activity
HGD77_06580	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HGD77_06585	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HGD77_06595	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HGD77_06600	COG1137	ATPase activity
HGD77_06635	COG4122	O-methyltransferase activity
HGD77_06645	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HGD77_06685	COG2011	ABC-type metal ion transport system permease component
HGD77_06690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HGD77_06695	COG1464	Belongs to the NlpA lipoprotein family
HGD77_06715	COG0138	bifunctional purine biosynthesis protein purh
HGD77_06720	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HGD77_06755	COG2814	Major facilitator Superfamily
HGD77_06770	COG3852	Histidine kinase
HGD77_06790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HGD77_06795	COG0575	Belongs to the CDS family
HGD77_06810	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGD77_06825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HGD77_06830	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HGD77_06845	COG2137	regulation of response to DNA damage stimulus
HGD77_06850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HGD77_06855	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HGD77_06860	COG1011	Hydrolase
HGD77_06875	COG0268	Binds directly to 16S ribosomal RNA
HGD77_06880	COG0702	epimerase
HGD77_06885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HGD77_06895	COG2197	response regulator
HGD77_06900	COG4585	Histidine kinase
HGD77_06905	COG2850	peptidyl-arginine hydroxylation
HGD77_06910	COG0424	maF-like protein
HGD77_06935	COG0697	spore germination
HGD77_06945	COG0778	Nitroreductase
HGD77_06990	COG3781	membrane
HGD77_07020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HGD77_07025	COG1027	Aspartate ammonia-lyase
HGD77_07035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HGD77_07065	COG0316	Belongs to the HesB IscA family
HGD77_07070	COG0822	iron-sulfur transferase activity
HGD77_07095	COG0776	regulation of translation
HGD77_07100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGD77_07120	COG1585	Membrane protein implicated in regulation of membrane protease activity
HGD77_07130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGD77_07150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HGD77_07155	COG0569	domain protein
HGD77_07160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HGD77_07165	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HGD77_07185	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HGD77_07190	COG0542	response to heat
HGD77_07220	COG0372	Belongs to the citrate synthase family
HGD77_07280	COG2814	Major facilitator Superfamily
HGD77_07300	COG0439	Biotin carboxylase
HGD77_07310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HGD77_07315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HGD77_07350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HGD77_07380	COG0596	Alpha beta hydrolase
HGD77_07425	COG0642	Histidine kinase
HGD77_07430	COG0745	RESPONSE REGULATOR receiver
HGD77_07435	COG2194	sulfuric ester hydrolase activity
HGD77_07450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HGD77_07505	COG0583	DNA-binding transcription factor activity
HGD77_07510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGD77_07530	COG2233	PERMEase
HGD77_07535	COG2351	hydroxyisourate hydrolase activity
HGD77_07565	COG1012	belongs to the aldehyde dehydrogenase family
HGD77_07570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HGD77_07595	COG1028	Short-chain dehydrogenase reductase Sdr
HGD77_07610	COG1024	Enoyl-CoA hydratase
HGD77_07615	COG1960	acyl-CoA dehydrogenase activity
HGD77_07620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HGD77_07635	COG0583	DNA-binding transcription factor activity
HGD77_07670	COG0318	PFAM AMP-dependent synthetase and ligase
HGD77_07685	COG1960	acyl-CoA dehydrogenase activity
HGD77_07695	COG1024	Enoyl-CoA hydratase
HGD77_07700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGD77_07705	COG0235	Class ii aldolase
HGD77_07715	COG0183	Belongs to the thiolase family
HGD77_07725	COG1024	Enoyl-CoA hydratase
HGD77_07730	COG2814	Major facilitator Superfamily
HGD77_07740	COG2814	Major facilitator Superfamily
HGD77_07745	COG5001	Diguanylate cyclase
HGD77_07750	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HGD77_07755	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HGD77_07760	COG2814	Major facilitator Superfamily
HGD77_07765	COG1960	acyl-CoA dehydrogenase activity
HGD77_07770	COG1960	acyl-CoA dehydrogenase activity
HGD77_07780	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HGD77_07780	COG0644	oxidoreductase
HGD77_07785	COG1944	ATP diphosphatase activity
HGD77_07805	COG1309	transcriptional regulator
HGD77_07820	COG4771	TonB-dependent receptor
HGD77_07825	COG0583	DNA-binding transcription factor activity
HGD77_07840	COG0515	serine threonine protein kinase
HGD77_07845	COG2116	formate transmembrane transporter activity
HGD77_07850	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HGD77_07855	COG2223	nitrite transmembrane transporter activity
HGD77_07860	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HGD77_07865	COG4149	molybdate abc transporter
HGD77_07870	COG0725	ABC transporter, periplasmic molybdate-binding protein
HGD77_07875	COG0303	'Molybdopterin
HGD77_07880	COG0521	Mo-molybdopterin cofactor biosynthetic process
HGD77_07880	COG0315	cyclic pyranopterin monophosphate synthase activity
HGD77_07885	COG0314	molybdopterin synthase activity
HGD77_07895	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HGD77_07905	COG0243	molybdopterin cofactor binding
HGD77_07910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HGD77_07915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HGD77_07925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HGD77_07925	COG1116	anion transmembrane transporter activity
HGD77_07930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGD77_07950	COG1064	alcohol dehydrogenase
HGD77_07975	COG0864	Transcriptional regulator
HGD77_07980	COG1196	nuclear chromosome segregation
HGD77_07985	COG0439	Biotin carboxylase
HGD77_08005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HGD77_08020	COG1017	nitric oxide dioxygenase activity
HGD77_08020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HGD77_08025	COG0318	PFAM AMP-dependent synthetase and ligase
HGD77_08030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGD77_08040	COG2814	Major facilitator Superfamily
HGD77_08045	COG0583	DNA-binding transcription factor activity
HGD77_08050	COG4948	Mandelate Racemase Muconate Lactonizing
HGD77_08055	COG4829	muconolactone delta-isomerase
HGD77_08075	COG4638	Rieske (2fe-2S)
HGD77_08080	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HGD77_08085	COG0633	Ferredoxin
HGD77_08085	COG0543	2 iron, 2 sulfur cluster binding
HGD77_08090	COG1028	Short-chain dehydrogenase reductase Sdr
HGD77_08095	COG3135	benzoate transporter
HGD77_08100	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HGD77_08105	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HGD77_08110	COG0183	Belongs to the thiolase family
HGD77_08115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HGD77_08140	COG0183	Belongs to the thiolase family
HGD77_08145	COG1960	acyl-CoA dehydrogenase activity
HGD77_08160	COG0789	Transcriptional regulator
HGD77_08170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HGD77_08185	COG0640	Transcriptional regulator
HGD77_08205	COG3122	Protein conserved in bacteria
HGD77_08210	COG0668	transmembrane transport
HGD77_08215	COG1132	(ABC) transporter
HGD77_08225	COG0509	glycine decarboxylation via glycine cleavage system
HGD77_08230	COG2814	Major facilitator Superfamily
HGD77_08245	COG2801	Transposase and inactivated derivatives
HGD77_08250	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HGD77_08260	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HGD77_08265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGD77_08330	COG1525	nuclease
HGD77_08340	COG1294	oxidase, subunit
HGD77_08345	COG1271	oxidase subunit
HGD77_08360	COG2169	Transcriptional regulator
HGD77_08365	COG1960	acyl-CoA dehydrogenase activity
HGD77_08370	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGD77_08375	COG2207	Transcriptional regulator
HGD77_08380	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HGD77_08385	COG0730	response to heat
HGD77_08390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HGD77_08455	COG1960	acyl-CoA dehydrogenase activity
HGD77_08460	COG0456	acetyltransferase
HGD77_08495	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HGD77_08510	COG0552	protein localization to endoplasmic reticulum
HGD77_08515	COG0612	Peptidase, M16
HGD77_08545	COG0517	IMP dehydrogenase activity
HGD77_08550	COG0133	tryptophan synthase activity
HGD77_08560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGD77_08580	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HGD77_08610	COG0537	adenosine 5'-monophosphoramidase activity
HGD77_08635	COG1294	oxidase, subunit
HGD77_08640	COG4890	Cyd operon protein YbgT
HGD77_08650	COG3385	transposase activity
HGD77_08655	COG0772	Belongs to the SEDS family
HGD77_08670	COG0148	phosphopyruvate hydratase activity
HGD77_08715	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGD77_08715	COG1902	pentaerythritol trinitrate reductase activity
HGD77_08730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HGD77_08735	COG0583	DNA-binding transcription factor activity
HGD77_08815	COG1570	exodeoxyribonuclease VII activity
HGD77_08825	COG3385	transposase activity
HGD77_08870	COG0729	surface antigen
HGD77_08875	COG0477	Major facilitator Superfamily
HGD77_08890	COG3293	Transposase
HGD77_08925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HGD77_08935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HGD77_08940	COG1960	acyl-CoA dehydrogenase activity
HGD77_08960	COG2890	protein-(glutamine-N5) methyltransferase activity
HGD77_08965	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HGD77_08980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGD77_09005	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HGD77_09010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HGD77_09015	COG1845	cytochrome c oxidase, subunit III
HGD77_09020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HGD77_09030	COG0360	Binds together with S18 to 16S ribosomal RNA
HGD77_09045	COG0305	Participates in initiation and elongation during chromosome replication
HGD77_09050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HGD77_09065	COG1305	Transglutaminase-like
HGD77_09075	COG2308	Evidence 4 Homologs of previously reported genes of
HGD77_09085	COG0069	glutamate synthase activity
HGD77_09105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HGD77_09110	COG1454	alcohol dehydrogenase
HGD77_09115	COG0824	Thioesterase
HGD77_09140	COG1028	Short-chain dehydrogenase reductase Sdr
HGD77_09145	COG0183	Belongs to the thiolase family
HGD77_09160	COG0583	DNA-binding transcription factor activity
HGD77_09165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HGD77_09175	COG3135	benzoate transporter
HGD77_09190	COG0589	response to stress
HGD77_09195	COG0589	response to stress
HGD77_09205	COG0308	aminopeptidase N
HGD77_09230	COG1253	flavin adenine dinucleotide binding
HGD77_09250	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HGD77_09255	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HGD77_09270	COG2431	L-lysine efflux transmembrane transporter activity
HGD77_09285	COG0776	regulation of translation
HGD77_09345	COG1309	transcriptional regulator
HGD77_09350	COG0084	hydrolase, TatD family'
HGD77_09370	COG1663	tetraacyldisaccharide 4'-kinase activity
HGD77_09390	COG1475	DNA binding
HGD77_09405	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HGD77_09410	COG3178	'Phosphotransferase
HGD77_09420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGD77_09425	COG1923	regulation of RNA biosynthetic process
HGD77_09435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HGD77_09440	COG0802	atpase or kinase
HGD77_09475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HGD77_09495	COG1643	Atp-dependent helicase
HGD77_09520	COG3634	alkyl hydroperoxide reductase activity
HGD77_09550	COG1254	Belongs to the acylphosphatase family
HGD77_09580	COG0582	viral genome integration into host DNA
HGD77_09610	COG4372	Transposase
HGD77_09635	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HGD77_09660	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HGD77_09675	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HGD77_09680	COG1116	anion transmembrane transporter activity
HGD77_09685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGD77_09690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGD77_09740	COG0204	Acyl-transferase
HGD77_09780	COG0012	GTP binding
HGD77_09795	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HGD77_09815	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HGD77_09820	COG0436	Aminotransferase
HGD77_09825	COG0386	Belongs to the glutathione peroxidase family
HGD77_09830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGD77_09835	COG0436	Aminotransferase
HGD77_09860	COG2351	hydroxyisourate hydrolase activity
HGD77_09880	COG1686	Belongs to the peptidase S11 family
HGD77_09890	COG1252	NADH dehydrogenase
HGD77_09910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HGD77_09925	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HGD77_09940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HGD77_09945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HGD77_09950	COG0527	aspartate kinase activity
HGD77_09960	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HGD77_09980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HGD77_09985	COG2252	PERMEase
HGD77_10010	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HGD77_10015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HGD77_10025	COG0693	protein deglycase activity
HGD77_10035	COG1960	acyl-CoA dehydrogenase activity
HGD77_10040	COG1301	dicarboxylic acid transport
HGD77_10050	COG3139	Protein of unknown function (DUF1315)
HGD77_10055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HGD77_10060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HGD77_10070	COG0494	nUDIX hydrolase
HGD77_10080	COG0642	Histidine kinase
HGD77_10085	COG0745	RESPONSE REGULATOR receiver
HGD77_10095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HGD77_10105	COG1720	tRNA m6t6A37 methyltransferase activity
HGD77_10140	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HGD77_10145	COG3634	alkyl hydroperoxide reductase activity
HGD77_10165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HGD77_10220	COG3706	GGDEF domain
HGD77_10230	COG1131	(ABC) transporter
HGD77_10235	COG0842	Transport permease protein
HGD77_10250	COG2951	lytic endotransglycosylase activity
HGD77_10275	COG0052	Belongs to the universal ribosomal protein uS2 family
HGD77_10285	COG0436	Aminotransferase
HGD77_10290	COG0534	Mate efflux family protein
HGD77_10315	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HGD77_10330	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HGD77_10335	COG0571	ribonuclease III activity
HGD77_10360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGD77_10410	COG2433	Pfam Transposase IS66
HGD77_10445	COG2433	Pfam Transposase IS66
HGD77_10495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HGD77_10505	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HGD77_10510	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HGD77_10525	COG4208	sulfate ABC transporter
HGD77_10530	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HGD77_10535	COG0583	DNA-binding transcription factor activity
HGD77_10555	COG0602	queuosine metabolic process
HGD77_10560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HGD77_10570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HGD77_10575	COG2353	YceI-like domain
HGD77_10585	COG0583	DNA-binding transcription factor activity
HGD77_10590	COG1051	belongs to the nudix hydrolase family
HGD77_10590	COG1056	cytidyltransferase-related domain
HGD77_10600	COG0778	Nitroreductase
HGD77_10605	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HGD77_10615	COG0583	DNA-binding transcription factor activity
HGD77_10630	COG0047	phosphoribosylformylglycinamidine synthase activity
HGD77_10630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HGD77_10650	COG2255	four-way junction helicase activity
HGD77_10665	COG1473	amidohydrolase
HGD77_10670	COG0824	Thioesterase
HGD77_10690	COG0823	Involved in the tonB-independent uptake of proteins
HGD77_10710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGD77_10740	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HGD77_10745	COG0628	permease
HGD77_10750	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HGD77_10755	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HGD77_10760	COG2267	carboxylic ester hydrolase activity
HGD77_10780	COG1136	(ABC) transporter
HGD77_10800	COG1671	Belongs to the UPF0178 family
HGD77_10820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGD77_10860	COG1280	lysine exporter protein (LysE YggA)
HGD77_10865	COG1522	sequence-specific DNA binding
HGD77_10875	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HGD77_10890	COG0019	diaminopimelate decarboxylase activity
HGD77_10900	COG1113	amino acid transport
HGD77_10905	COG1115	amino acid carrier protein
HGD77_10950	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HGD77_10955	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HGD77_10960	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HGD77_10965	COG1716	ATPase activity
HGD77_10965	COG5001	Diguanylate cyclase
HGD77_10980	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HGD77_11000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HGD77_11015	COG0037	tRNA processing
HGD77_11020	COG1196	nuclear chromosome segregation
HGD77_11020	COG0741	lytic transglycosylase activity
HGD77_11020	COG0739	heme binding
HGD77_11025	COG0501	Belongs to the peptidase M48B family
HGD77_11035	COG2239	Acts as a magnesium transporter
HGD77_11060	COG1253	flavin adenine dinucleotide binding
HGD77_11100	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HGD77_11110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGD77_11140	COG0505	Belongs to the CarA family
HGD77_11145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HGD77_11155	COG1309	transcriptional regulator
HGD77_11160	COG0251	oxidation-reduction process
HGD77_11185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HGD77_11210	COG0564	pseudouridine synthase activity
HGD77_11220	COG0358	DNA primase activity
HGD77_11225	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HGD77_11235	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HGD77_11265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HGD77_11270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HGD77_11295	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HGD77_11320	COG0586	Pfam SNARE associated Golgi protein
HGD77_11365	COG0531	amino acid
HGD77_11375	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HGD77_11380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HGD77_11380	COG1648	precorrin-2 dehydrogenase activity
HGD77_11385	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HGD77_11395	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HGD77_11405	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HGD77_11420	COG0671	phosphoesterase, PA-phosphatase related
HGD77_11425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGD77_11440	COG0393	Putative heavy-metal-binding
HGD77_11445	COG0393	Putative heavy-metal-binding
HGD77_11475	COG2203	Gaf domain
HGD77_11475	COG5001	Diguanylate cyclase
HGD77_11475	COG4251	negative regulation of phosphorylation
HGD77_11475	COG3706	GGDEF domain
HGD77_11490	COG4681	YaeQ
HGD77_11495	COG0523	cobalamin synthesis protein
HGD77_11515	COG0583	DNA-binding transcription factor activity
HGD77_11530	COG1607	acyl-coa hydrolase
HGD77_11540	COG1752	Esterase of the alpha-beta hydrolase superfamily
HGD77_11545	COG2059	Chromate
HGD77_11550	COG1115	amino acid carrier protein
HGD77_11555	COG0786	glutamate:sodium symporter activity
HGD77_11640	COG2832	Protein of unknown function (DUF454)
HGD77_11670	COG0840	transmembrane signaling receptor activity
HGD77_11700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGD77_11745	COG0489	protein tyrosine kinase activity
HGD77_11765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGD77_11765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGD77_11780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGD77_11805	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HGD77_11815	COG2081	HI0933 family
HGD77_11830	COG0668	transmembrane transport
HGD77_11840	COG4302	ethanolamine ammonia-lyase activity
HGD77_11845	COG4303	Ethanolamine ammonia lyase large subunit
HGD77_11870	COG0583	DNA-binding transcription factor activity
HGD77_11875	COG1278	Cold shock
HGD77_11900	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGD77_11905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HGD77_11910	COG0713	ATP synthesis coupled electron transport
HGD77_11920	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGD77_11935	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HGD77_11955	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGD77_11965	COG2205	protein histidine kinase activity
HGD77_11970	COG0745	RESPONSE REGULATOR receiver
HGD77_11975	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HGD77_11975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGD77_11985	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGD77_12020	COG4372	Transposase
HGD77_12045	COG2433	Pfam Transposase IS66
HGD77_12065	COG4372	Transposase
HGD77_12145	COG0351	phosphomethylpyrimidine kinase
HGD77_12145	COG0352	thiamine-phosphate diphosphorylase activity
HGD77_12145	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HGD77_12170	COG2824	Alkylphosphonate utilization operon protein PhnA
HGD77_12190	COG0564	pseudouridine synthase activity
HGD77_12235	COG2132	Multicopper oxidase
HGD77_12240	COG0354	folic acid binding
HGD77_12260	COG1902	pentaerythritol trinitrate reductase activity
HGD77_12295	COG2233	PERMEase
HGD77_12305	COG0833	amino acid
HGD77_12320	COG4968	Prepilin-type N-terminal cleavage methylation domain
HGD77_12325	COG0183	Belongs to the thiolase family
HGD77_12345	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HGD77_12350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HGD77_12355	COG2207	Transcriptional regulator
HGD77_12360	COG0183	Belongs to the thiolase family
HGD77_12365	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGD77_12365	COG1024	Enoyl-CoA hydratase
HGD77_12385	COG1272	protein, Hemolysin III
HGD77_12390	COG0477	Major facilitator Superfamily
HGD77_12400	COG1408	metallophosphoesterase
HGD77_12405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGD77_12415	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HGD77_12430	COG3293	Transposase
HGD77_12460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HGD77_12465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HGD77_12470	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HGD77_12475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HGD77_12480	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HGD77_12485	COG0625	glutathione transferase activity
HGD77_12490	COG2969	positive regulation of protein catabolic process
HGD77_12510	COG2433	Pfam Transposase IS66
HGD77_12560	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HGD77_12565	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HGD77_12575	COG0653	protein targeting
HGD77_12580	COG0450	alkyl hydroperoxide reductase
HGD77_12595	COG0285	dihydrofolate synthase activity
HGD77_12645	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HGD77_12655	COG1704	LemA family
HGD77_12670	COG1862	Preprotein translocase
HGD77_12680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HGD77_12690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HGD77_12705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HGD77_12720	COG2084	Dehydrogenase
HGD77_12725	COG3622	Belongs to the hyi family
HGD77_12775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HGD77_12785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HGD77_12790	COG2003	Belongs to the UPF0758 family
HGD77_12795	COG3781	membrane
HGD77_12810	COG2350	Protein conserved in bacteria
HGD77_12845	COG1607	acyl-coa hydrolase
HGD77_12905	COG1183	phosphatidylcholine synthase activity
HGD77_12910	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HGD77_12950	COG0741	lytic transglycosylase activity
HGD77_12950	COG0739	heme binding
HGD77_12950	COG1196	nuclear chromosome segregation
HGD77_12955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGD77_12960	COG1702	phosphate starvation-inducible protein PhoH
HGD77_13015	COG1295	ribonuclease BN
HGD77_13035	COG0179	Fumarylacetoacetate (FAA) hydrolase
HGD77_13075	COG0557	exoribonuclease II activity
HGD77_13085	COG0339	signal peptide processing
HGD77_13090	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HGD77_13100	COG0697	spore germination
HGD77_13125	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HGD77_13130	COG1960	acyl-CoA dehydrogenase activity
HGD77_13135	COG2072	flavoprotein involved in K transport
HGD77_13140	COG0203	ribosomal protein L17
HGD77_13145	COG0202	RNA polymerase activity
HGD77_13150	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HGD77_13160	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HGD77_13185	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HGD77_13195	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HGD77_13200	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HGD77_13250	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HGD77_13260	COG0089	rRNA binding
HGD77_13265	COG0088	Forms part of the polypeptide exit tunnel
HGD77_13285	COG0626	cystathionine gamma-synthase activity
HGD77_13305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HGD77_13305	COG1017	nitric oxide dioxygenase activity
HGD77_13310	COG1959	2 iron, 2 sulfur cluster binding
HGD77_13320	COG1301	dicarboxylic acid transport
HGD77_13325	COG1946	Acyl-CoA thioesterase
HGD77_13330	COG2937	Belongs to the GPAT DAPAT family
HGD77_13350	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HGD77_13355	COG1040	competence protein
HGD77_13360	COG0494	nUDIX hydrolase
HGD77_13370	COG0598	Magnesium transport protein CorA
HGD77_13390	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HGD77_13395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HGD77_13400	COG1127	ABC transporter
HGD77_13405	COG0513	Belongs to the DEAD box helicase family
HGD77_13425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGD77_13445	COG1960	acyl-CoA dehydrogenase activity
HGD77_13450	COG1278	Cold shock
HGD77_13470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGD77_13480	COG0534	Mate efflux family protein
HGD77_13490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HGD77_13495	COG0254	rRNA binding
HGD77_13500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HGD77_13535	COG0628	permease
HGD77_13545	COG1289	transmembrane transporter activity
HGD77_13550	COG2814	Major facilitator Superfamily
HGD77_13570	COG0277	FAD linked oxidase domain protein
HGD77_13575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGD77_13625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HGD77_13630	COG5380	lipid catabolic process
HGD77_13635	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HGD77_13640	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HGD77_13655	COG0335	large ribosomal subunit rRNA binding
HGD77_13665	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HGD77_13670	COG0228	four-way junction DNA binding
HGD77_13690	COG0194	GDP metabolic process
HGD77_13695	COG1758	RNA polymerase activity
HGD77_13700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HGD77_13725	COG3307	-O-antigen
HGD77_13755	COG1704	LemA family
HGD77_13760	COG0493	'glutamate synthase
HGD77_13765	COG0070	glutamate synthase
HGD77_13765	COG0069	glutamate synthase activity
HGD77_13765	COG0067	glutamate synthase
HGD77_13815	COG2226	methyltransferase
HGD77_13820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HGD77_13825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HGD77_13830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HGD77_13850	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HGD77_13865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGD77_13885	COG0488	(ABC) transporter
HGD77_13890	COG2873	o-acetylhomoserine
HGD77_13895	COG4221	oxidoreductase activity
HGD77_13900	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HGD77_13915	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HGD77_13915	COG2111	Na H antiporter
HGD77_13920	COG1006	Multisubunit Na H antiporter MnhC subunit
HGD77_13925	COG0651	ATP synthesis coupled electron transport
HGD77_13930	COG1863	multisubunit Na H antiporter MnhE subunit
HGD77_13935	COG2212	antiporter activity
HGD77_13945	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HGD77_13955	COG0195	Participates in both transcription termination and antitermination
HGD77_13960	COG0779	Required for maturation of 30S ribosomal subunits
HGD77_14015	COG0237	dephospho-CoA kinase activity
HGD77_14025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGD77_14030	COG3123	guanosine phosphorylase activity
HGD77_14035	COG0497	DNA recombination
HGD77_14045	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HGD77_14055	COG1132	(ABC) transporter
HGD77_14065	COG1538	Outer membrane efflux protein
HGD77_14080	COG0494	nUDIX hydrolase
HGD77_14090	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HGD77_14095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGD77_14105	COG0772	Belongs to the SEDS family
HGD77_14130	COG4974	Belongs to the 'phage' integrase family
HGD77_14135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HGD77_14145	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HGD77_14150	COG1686	Belongs to the peptidase S11 family
HGD77_14155	COG2197	response regulator
HGD77_14170	COG3409	Peptidoglycan-binding domain 1 protein
HGD77_14170	COG0793	Belongs to the peptidase S41A family
HGD77_14175	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HGD77_14180	COG0795	lipopolysaccharide-transporting ATPase activity
HGD77_14185	COG0795	lipopolysaccharide-transporting ATPase activity
HGD77_14205	COG0586	Pfam SNARE associated Golgi protein
HGD77_14220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HGD77_14220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HGD77_14230	COG0004	ammonium transporteR
HGD77_14235	COG0347	Belongs to the P(II) protein family
HGD77_14245	COG0606	chelatase, subunit chli
HGD77_14255	COG4372	Transposase
HGD77_14265	COG2963	transposase activity
HGD77_14290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HGD77_14320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGD77_14385	COG0606	chelatase, subunit chli
HGD77_14405	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HGD77_14430	COG0477	Major facilitator Superfamily
HGD77_14435	COG2860	membrane
HGD77_14445	COG1253	flavin adenine dinucleotide binding
HGD77_14480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HGD77_14485	COG0477	Major facilitator Superfamily
HGD77_14505	COG2814	Major facilitator Superfamily
HGD77_14555	COG0758	DNA mediated transformation
HGD77_14565	COG0697	spore germination
HGD77_14570	COG0386	Belongs to the glutathione peroxidase family
HGD77_14585	COG1012	belongs to the aldehyde dehydrogenase family
HGD77_14605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HGD77_14655	COG1121	(ABC) transporter
HGD77_14670	COG2837	iron assimilation
HGD77_14715	COG3501	Rhs element vgr protein
HGD77_14725	COG0534	Mate efflux family protein
HGD77_14760	COG2433	Pfam Transposase IS66
HGD77_14775	COG3706	GGDEF domain
HGD77_14780	COG3706	GGDEF domain
HGD77_14785	COG0519	Catalyzes the synthesis of GMP from XMP
HGD77_14785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HGD77_14790	COG0586	Pfam SNARE associated Golgi protein
HGD77_14805	COG1192	Involved in chromosome partitioning
HGD77_14815	COG0271	Belongs to the BolA IbaG family
HGD77_14850	COG3756	Protein conserved in bacteria
HGD77_14880	COG3335	DDE superfamily endonuclease
HGD77_14900	COG1012	belongs to the aldehyde dehydrogenase family
HGD77_14905	COG3138	arginine N-succinyltransferase
HGD77_14910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HGD77_14915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HGD77_14930	COG2826	transposase and inactivated derivatives, IS30 family
HGD77_14960	COG0494	nUDIX hydrolase
HGD77_15000	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HGD77_15050	COG3540	Alkaline phosphatase
HGD77_15080	COG1538	Outer membrane efflux protein
HGD77_15140	COG0281	malic enzyme
HGD77_15160	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HGD77_15175	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HGD77_15185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HGD77_15230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGD77_15240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HGD77_15255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HGD77_15280	COG0438	transferase activity, transferring glycosyl groups
HGD77_15285	COG0438	transferase activity, transferring glycosyl groups
HGD77_15320	COG1088	dTDP-glucose 4,6-dehydratase activity
HGD77_15330	COG2244	polysaccharide biosynthetic process
HGD77_15345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HGD77_15355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HGD77_15360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HGD77_15365	COG0438	transferase activity, transferring glycosyl groups
HGD77_15375	COG0438	transferase activity, transferring glycosyl groups
HGD77_15400	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HGD77_15435	COG4372	Transposase
HGD77_15495	COG3189	MarR family transcriptional regulator
HGD77_15505	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HGD77_15510	COG2249	NAD(P)H dehydrogenase (quinone) activity
HGD77_15515	COG0583	DNA-binding transcription factor activity
HGD77_15545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HGD77_15550	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HGD77_15625	COG3293	Transposase
HGD77_15630	COG4372	Transposase
HGD77_15655	COG1309	transcriptional regulator
HGD77_15665	COG1902	pentaerythritol trinitrate reductase activity
HGD77_15690	COG1979	alcohol dehydrogenase
HGD77_15705	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HGD77_15720	COG3321	synthase
HGD77_15720	COG0604	alcohol dehydrogenase
HGD77_15725	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HGD77_15730	COG0583	DNA-binding transcription factor activity
HGD77_15735	COG4221	oxidoreductase activity
HGD77_15860	COG0431	NADPH-dependent FMN reductase
HGD77_15875	COG2132	Multicopper oxidase
HGD77_15890	COG2205	protein histidine kinase activity
HGD77_15895	COG3174	membrane
HGD77_15900	COG2217	Heavy metal translocating P-type atpase
HGD77_15920	COG3293	Transposase
HGD77_15935	COG2826	transposase and inactivated derivatives, IS30 family
HGD77_15990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HGD77_16030	COG1764	response to oxidative stress
HGD77_16035	COG1846	Transcriptional regulator
HGD77_16040	COG3293	Transposase
HGD77_16045	COG0804	urea catabolic process
HGD77_16055	COG0831	urea catabolic process
HGD77_16060	COG0829	nickel cation binding
HGD77_16075	COG0830	nickel cation binding
HGD77_16100	COG3293	Transposase
HGD77_16110	COG1192	Involved in chromosome partitioning
HGD77_16150	COG2433	Pfam Transposase IS66
HGD77_16170	COG4774	siderophore transport
HGD77_16190	COG1454	alcohol dehydrogenase
HGD77_16215	COG4773	Receptor
HGD77_16235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGD77_16255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HGD77_16260	COG2267	carboxylic ester hydrolase activity
HGD77_16260	COG2226	methyltransferase
HGD77_16265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HGD77_16265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HGD77_16275	COG4106	trans-aconitate 2-methyltransferase activity
HGD77_16285	COG0642	Histidine kinase
HGD77_16300	COG2186	Transcriptional regulator
HGD77_16315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGD77_16315	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGD77_16320	COG1105	Belongs to the carbohydrate kinase PfkB family
HGD77_16335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HGD77_16380	COG4962	Type ii secretion system protein e
HGD77_16395	COG3451	type IV secretory pathway VirB4
HGD77_16415	COG3846	protein secretion by the type IV secretion system
HGD77_16420	COG3701	Conjugal transfer protein
HGD77_16425	COG3504	Conjugal transfer protein
HGD77_16440	COG2948	multi-organism process
HGD77_16465	COG2026	Addiction module toxin, RelE StbE family
HGD77_16565	COG2814	Major facilitator Superfamily
HGD77_16580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HGD77_16625	COG0741	lytic transglycosylase activity
HGD77_16625	COG1196	nuclear chromosome segregation
HGD77_16625	COG0739	heme binding
HGD77_16705	COG3077	Addiction module antitoxin, RelB DinJ family
HGD77_16715	COG2801	Transposase and inactivated derivatives
HGD77_16725	COG2433	Pfam Transposase IS66
HGD77_16805	COG2801	Transposase and inactivated derivatives
HGD77_16815	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HGD77_16840	COG0659	secondary active sulfate transmembrane transporter activity
HGD77_16860	COG4735	regulation of single-species biofilm formation