locus-tag	class	description
HUK62_00005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUK62_00020	COG0431	NADPH-dependent FMN reductase
HUK62_00035	COG1028	Short-chain dehydrogenase reductase Sdr
HUK62_00040	COG0307	riboflavin synthase, alpha
HUK62_00045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUK62_00050	COG0668	transmembrane transport
HUK62_00055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUK62_00060	COG1519	Transferase
HUK62_00065	COG1902	pentaerythritol trinitrate reductase activity
HUK62_00090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUK62_00115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUK62_00115	COG0426	domain, Protein
HUK62_00120	COG2119	membrane
HUK62_00125	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUK62_00150	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUK62_00160	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUK62_00170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUK62_00200	COG0189	ligase activity
HUK62_00205	COG0386	Belongs to the glutathione peroxidase family
HUK62_00210	COG1846	Transcriptional regulator
HUK62_00235	COG0708	Exodeoxyribonuclease III
HUK62_00240	COG1393	Belongs to the ArsC family
HUK62_00255	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUK62_00335	COG3293	Transposase
HUK62_00365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUK62_00395	COG4372	Transposase
HUK62_00440	COG3150	esterase
HUK62_00450	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HUK62_00455	COG2918	glutathione biosynthetic process
HUK62_00470	COG2733	membrane
HUK62_00475	COG0436	Aminotransferase
HUK62_00480	COG0534	Mate efflux family protein
HUK62_00550	COG0385	Bile acid
HUK62_00555	COG1335	isochorismatase
HUK62_00560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUK62_00585	COG4215	(ABC) transporter
HUK62_00590	COG4160	amino acid transport
HUK62_00610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUK62_00615	COG2983	Belongs to the UPF0260 family
HUK62_00620	COG5487	UPF0391 membrane protein
HUK62_00650	COG2818	Glycosylase
HUK62_00655	COG1064	alcohol dehydrogenase
HUK62_00660	COG0436	Aminotransferase
HUK62_00675	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUK62_00705	COG1309	transcriptional regulator
HUK62_00715	COG2233	PERMEase
HUK62_00720	COG0583	DNA-binding transcription factor activity
HUK62_00730	COG4774	siderophore transport
HUK62_00740	COG0129	dihydroxy-acid dehydratase activity
HUK62_00755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUK62_00755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUK62_00770	COG0733	neurotransmitter:sodium symporter activity
HUK62_00780	COG2814	Major facilitator Superfamily
HUK62_00810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUK62_00895	COG0488	(ABC) transporter
HUK62_00900	COG0675	Transposase, IS605 OrfB family
HUK62_00915	COG3385	transposase activity
HUK62_00920	COG0187	DNA topoisomerase II activity
HUK62_00930	COG0592	DNA-directed DNA polymerase activity
HUK62_00935	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUK62_00950	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUK62_00955	COG0706	membrane insertase activity
HUK62_00965	COG0281	malic enzyme
HUK62_00970	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HUK62_00985	COG0583	DNA-binding transcription factor activity
HUK62_01000	COG1230	cation diffusion facilitator family transporter
HUK62_01020	COG0402	S-adenosylhomocysteine deaminase activity
HUK62_01030	COG0754	glutathionylspermidine amidase activity
HUK62_01040	COG0861	Integral membrane protein TerC family
HUK62_01060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUK62_01075	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUK62_01080	COG2951	lytic endotransglycosylase activity
HUK62_01085	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HUK62_01090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUK62_01120	COG2133	pyrroloquinoline quinone binding
HUK62_01145	COG1047	Peptidyl-prolyl cis-trans
HUK62_01150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUK62_01155	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUK62_01160	COG0196	riboflavin kinase activity
HUK62_01175	COG1309	transcriptional regulator
HUK62_01180	COG1116	anion transmembrane transporter activity
HUK62_01185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUK62_01190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUK62_01195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUK62_01200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUK62_01205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUK62_01205	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUK62_01230	COG1028	Short-chain dehydrogenase reductase Sdr
HUK62_01235	COG0546	phosphoglycolate phosphatase activity
HUK62_01240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUK62_01245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUK62_01250	COG3307	-O-antigen
HUK62_01260	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HUK62_01270	COG3023	N-Acetylmuramoyl-L-alanine amidase
HUK62_01275	COG0728	peptidoglycan biosynthetic process
HUK62_01295	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HUK62_01310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUK62_01320	COG0438	transferase activity, transferring glycosyl groups
HUK62_01325	COG0438	transferase activity, transferring glycosyl groups
HUK62_01330	COG0438	transferase activity, transferring glycosyl groups
HUK62_01335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUK62_01345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUK62_01355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUK62_01375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUK62_01380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUK62_01390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HUK62_01395	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HUK62_01405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUK62_01420	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HUK62_01430	COG0583	DNA-binding transcription factor activity
HUK62_01435	COG4628	conserved protein (DUF2132)
HUK62_01470	COG3550	peptidyl-serine autophosphorylation
HUK62_01550	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HUK62_01550	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HUK62_01585	COG3293	Transposase
HUK62_01605	COG2304	oxidoreductase activity
HUK62_01630	COG2826	transposase and inactivated derivatives, IS30 family
HUK62_01640	COG3293	Transposase
HUK62_01655	COG4628	conserved protein (DUF2132)
HUK62_01710	COG4372	Transposase
HUK62_01725	COG4372	Transposase
HUK62_01730	COG1538	Outer membrane efflux protein
HUK62_01735	COG1132	(ABC) transporter
HUK62_01965	COG0271	Belongs to the BolA IbaG family
HUK62_01975	COG1192	Involved in chromosome partitioning
HUK62_01990	COG0586	Pfam SNARE associated Golgi protein
HUK62_02005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUK62_02005	COG0519	Catalyzes the synthesis of GMP from XMP
HUK62_02060	COG0281	malic enzyme
HUK62_02065	COG3501	Rhs element vgr protein
HUK62_02080	COG2826	transposase and inactivated derivatives, IS30 family
HUK62_02095	COG2837	iron assimilation
HUK62_02100	COG1280	lysine exporter protein (LysE YggA)
HUK62_02105	COG1683	Conserved Protein
HUK62_02110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUK62_02115	COG1121	(ABC) transporter
HUK62_02165	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUK62_02200	COG0386	Belongs to the glutathione peroxidase family
HUK62_02210	COG0697	spore germination
HUK62_02220	COG0758	DNA mediated transformation
HUK62_02305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUK62_02315	COG2814	Major facilitator Superfamily
HUK62_02335	COG1253	flavin adenine dinucleotide binding
HUK62_02340	COG3012	SEC-C Motif Domain Protein
HUK62_02345	COG2860	membrane
HUK62_02350	COG0477	Major facilitator Superfamily
HUK62_02360	COG0318	PFAM AMP-dependent synthetase and ligase
HUK62_02375	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUK62_02395	COG0606	chelatase, subunit chli
HUK62_02405	COG0347	Belongs to the P(II) protein family
HUK62_02410	COG0004	ammonium transporteR
HUK62_02420	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUK62_02420	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUK62_02435	COG0586	Pfam SNARE associated Golgi protein
HUK62_02455	COG0795	lipopolysaccharide-transporting ATPase activity
HUK62_02460	COG0795	lipopolysaccharide-transporting ATPase activity
HUK62_02465	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HUK62_02470	COG0793	Belongs to the peptidase S41A family
HUK62_02485	COG2197	response regulator
HUK62_02490	COG1686	Belongs to the peptidase S11 family
HUK62_02500	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUK62_02510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUK62_02515	COG4974	Belongs to the 'phage' integrase family
HUK62_02535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUK62_02540	COG0772	Belongs to the SEDS family
HUK62_02545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUK62_02550	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUK62_02555	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HUK62_02565	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HUK62_02575	COG1538	Outer membrane efflux protein
HUK62_02595	COG3275	phosphorelay sensor kinase activity
HUK62_02605	COG0181	hydroxymethylbilane synthase activity
HUK62_02625	COG0824	Thioesterase
HUK62_02655	COG0546	phosphoglycolate phosphatase activity
HUK62_02685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUK62_02705	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUK62_02710	COG0081	regulation of translation
HUK62_02715	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUK62_02720	COG0222	ribosome binding
HUK62_02725	COG0085	RNA polymerase activity
HUK62_02730	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUK62_02755	COG2056	Na+-H+ antiporter family
HUK62_02760	COG3047	cAMP biosynthetic process
HUK62_02770	COG0326	Molecular chaperone. Has ATPase activity
HUK62_02800	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUK62_02875	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUK62_02880	COG1132	(ABC) transporter
HUK62_02895	COG1289	transmembrane transporter activity
HUK62_02915	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUK62_02920	COG1678	Uncharacterized ACR, COG1678
HUK62_02925	COG0497	DNA recombination
HUK62_02940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUK62_02950	COG0237	dephospho-CoA kinase activity
HUK62_03010	COG0195	Participates in both transcription termination and antitermination
HUK62_03015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUK62_03020	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUK62_03030	COG2212	antiporter activity
HUK62_03040	COG0651	ATP synthesis coupled electron transport
HUK62_03045	COG1006	Multisubunit Na H antiporter MnhC subunit
HUK62_03050	COG2111	Na H antiporter
HUK62_03050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUK62_03055	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUK62_03065	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUK62_03080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUK62_03120	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HUK62_03125	COG1074	ATP-dependent DNA helicase activity
HUK62_03130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUK62_03145	COG1185	polyribonucleotide nucleotidyltransferase activity
HUK62_03150	COG0598	Magnesium transport protein CorA
HUK62_03155	COG2841	Protein conserved in bacteria
HUK62_03175	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HUK62_03185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUK62_03205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUK62_03210	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HUK62_03215	COG4535	Mg2 and Co2 transporter CorC
HUK62_03220	COG0425	Belongs to the sulfur carrier protein TusA family
HUK62_03230	COG4372	Transposase
HUK62_03245	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HUK62_03245	COG0644	oxidoreductase
HUK62_03255	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUK62_03265	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HUK62_03270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUK62_03280	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HUK62_03305	COG2226	methyltransferase
HUK62_03320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUK62_03345	COG0751	glycine-tRNA ligase activity
HUK62_03365	COG1983	PspC domain protein
HUK62_03390	COG0318	PFAM AMP-dependent synthetase and ligase
HUK62_03395	COG1530	ribonuclease E activity
HUK62_03400	COG0564	pseudouridine synthase activity
HUK62_03415	COG0583	DNA-binding transcription factor activity
HUK62_03430	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HUK62_03475	COG1960	acyl-CoA dehydrogenase activity
HUK62_03490	COG1280	lysine exporter protein (LysE YggA)
HUK62_03525	COG0583	DNA-binding transcription factor activity
HUK62_03535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUK62_03550	COG0473	3-isopropylmalate dehydrogenase activity
HUK62_03610	COG1560	Kdo2-lipid A biosynthetic process
HUK62_03625	COG2900	Belongs to the SlyX family
HUK62_03665	COG1929	Belongs to the glycerate kinase type-1 family
HUK62_03670	COG0210	DNA helicase
HUK62_03695	COG4651	solute:proton antiporter activity
HUK62_03695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUK62_03720	COG0788	formyltetrahydrofolate deformylase activity
HUK62_03845	COG2813	Specifically methylates the guanine in position
HUK62_03845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUK62_03855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUK62_03870	COG4774	siderophore transport
HUK62_03880	COG4771	TonB-dependent receptor
HUK62_03890	COG0740	serine-type endopeptidase activity
HUK62_03910	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HUK62_03910	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HUK62_03920	COG1917	Cupin 2, conserved barrel domain protein
HUK62_03920	COG2207	Transcriptional regulator
HUK62_03930	COG2318	DinB family
HUK62_03940	COG0280	phosphate acetyltransferase
HUK62_03940	COG0857	belongs to the CobB CobQ family
HUK62_03945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUK62_03970	COG0793	Belongs to the peptidase S41A family
HUK62_03980	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HUK62_03995	COG0084	hydrolase, TatD family'
HUK62_04000	COG3293	Transposase
HUK62_04010	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HUK62_04025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUK62_04075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUK62_04130	COG2814	Major facilitator Superfamily
HUK62_04155	COG0004	ammonium transporteR
HUK62_04170	COG3622	Belongs to the hyi family
HUK62_04175	COG2084	Dehydrogenase
HUK62_04180	COG1024	Enoyl-CoA hydratase
HUK62_04185	COG5002	protein histidine kinase activity
HUK62_04185	COG2205	protein histidine kinase activity
HUK62_04185	COG0784	Response regulator, receiver
HUK62_04190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUK62_04205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUK62_04215	COG3956	TIGRFAM MazG family protein
HUK62_04220	COG1555	photosystem II stabilization
HUK62_04225	COG0617	tRNA 3'-terminal CCA addition
HUK62_04230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUK62_04240	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUK62_04245	COG1660	Displays ATPase and GTPase activities
HUK62_04255	COG3028	Belongs to the UPF0307 family
HUK62_04265	COG0318	PFAM AMP-dependent synthetase and ligase
HUK62_04285	COG0625	glutathione transferase activity
HUK62_04295	COG1238	metal cluster binding
HUK62_04345	COG0072	phenylalanine-tRNA ligase activity
HUK62_04370	COG0248	Ppx GppA phosphatase
HUK62_04380	COG0037	tRNA processing
HUK62_04395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUK62_04395	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUK62_04435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUK62_04445	COG2208	phosphoserine phosphatase activity
HUK62_04450	COG2853	Lipoprotein
HUK62_04480	COG2814	Major facilitator Superfamily
HUK62_04520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUK62_04530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUK62_04555	COG0494	nUDIX hydrolase
HUK62_04560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HUK62_04565	COG1214	PFAM Peptidase M22, glycoprotease
HUK62_04570	COG1968	undecaprenyl-diphosphatase activity
HUK62_04605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUK62_04615	COG2132	Multicopper oxidase
HUK62_04640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUK62_04650	COG0351	phosphomethylpyrimidine kinase
HUK62_04650	COG0352	thiamine-phosphate diphosphorylase activity
HUK62_04650	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HUK62_04680	COG0251	oxidation-reduction process
HUK62_04685	COG1113	amino acid transport
HUK62_04710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUK62_04725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUK62_04735	COG0456	acetyltransferase
HUK62_04745	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HUK62_04750	COG0492	ferredoxin-NADP+ reductase activity
HUK62_04755	COG0531	amino acid
HUK62_04755	COG1674	ftsk spoiiie
HUK62_04770	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HUK62_04775	COG2894	cell division
HUK62_04780	COG0850	regulation of cytokinetic process
HUK62_04790	COG0204	Acyl-transferase
HUK62_04795	COG2885	chlorophyll binding
HUK62_04800	COG0210	DNA helicase
HUK62_04805	COG0756	dUTP diphosphatase activity
HUK62_04825	COG0121	glutamine amidotransferase
HUK62_04830	COG2703	oxygen carrier activity
HUK62_04840	COG2914	Belongs to the UPF0125 (RnfH) family
HUK62_04845	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUK62_04850	COG0735	belongs to the Fur family
HUK62_04880	COG0420	3'-5' exonuclease activity
HUK62_04885	COG4251	negative regulation of phosphorylation
HUK62_04885	COG5001	Diguanylate cyclase
HUK62_04885	COG2203	Gaf domain
HUK62_04885	COG3706	GGDEF domain
HUK62_04895	COG1090	epimerase
HUK62_04910	COG2050	protein possibly involved in aromatic compounds catabolism
HUK62_04915	COG1566	PFAM secretion protein HlyD family protein
HUK62_04920	COG2814	Major facilitator Superfamily
HUK62_04925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUK62_04935	COG0582	viral genome integration into host DNA
HUK62_05010	COG2184	nucleotidyltransferase activity
HUK62_05055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUK62_05065	COG1136	(ABC) transporter
HUK62_05070	COG0640	Transcriptional regulator
HUK62_05095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUK62_05120	COG0640	Transcriptional regulator
HUK62_05130	COG0798	PFAM Bile acid sodium symporter
HUK62_05135	COG0431	NADPH-dependent FMN reductase
HUK62_05145	COG3177	Filamentation induced by cAMP protein fic
HUK62_05220	COG0303	'Molybdopterin
HUK62_05225	COG0315	cyclic pyranopterin monophosphate synthase activity
HUK62_05225	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUK62_05230	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUK62_05250	COG0725	ABC transporter, periplasmic molybdate-binding protein
HUK62_05255	COG4149	molybdate abc transporter
HUK62_05295	COG2814	Major facilitator Superfamily
HUK62_05300	COG0583	DNA-binding transcription factor activity
HUK62_05325	COG1522	sequence-specific DNA binding
HUK62_05355	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HUK62_05365	COG0583	DNA-binding transcription factor activity
HUK62_05370	COG2610	gluconate transmembrane transporter activity
HUK62_05375	COG1028	Short-chain dehydrogenase reductase Sdr
HUK62_05385	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HUK62_05420	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUK62_05430	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUK62_05435	COG1077	Cell shape determining protein MreB Mrl
HUK62_05440	COG1792	Involved in formation and maintenance of cell shape
HUK62_05445	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HUK62_05450	COG0424	maF-like protein
HUK62_05455	COG1530	ribonuclease E activity
HUK62_05465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUK62_05510	COG3293	Transposase
HUK62_05520	COG0640	Transcriptional regulator
HUK62_05530	COG0798	PFAM Bile acid sodium symporter
HUK62_05535	COG0431	NADPH-dependent FMN reductase
HUK62_05550	COG0625	glutathione transferase activity
HUK62_05570	COG1113	amino acid transport
HUK62_05585	COG1113	amino acid transport
HUK62_05590	COG2828	Protein conserved in bacteria
HUK62_05595	COG0142	geranyltranstransferase activity
HUK62_05610	COG1752	Esterase of the alpha-beta hydrolase superfamily
HUK62_05640	COG0745	RESPONSE REGULATOR receiver
HUK62_05645	COG0642	Histidine kinase
HUK62_05660	COG0004	ammonium transporteR
HUK62_05670	COG1126	abc transporter atp-binding protein
HUK62_05675	COG0765	amino acid transport
HUK62_05680	COG0765	amino acid transport
HUK62_05700	COG0668	transmembrane transport
HUK62_05715	COG2081	HI0933 family
HUK62_05720	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HUK62_05760	COG4716	Myosin-crossreactive antigen
HUK62_05810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUK62_05810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUK62_05835	COG0489	protein tyrosine kinase activity
HUK62_05850	COG2358	TRAP transporter, solute receptor (TAXI family
HUK62_05855	COG3293	Transposase
HUK62_05930	COG0840	transmembrane signaling receptor activity
HUK62_05935	COG2198	Histidine kinase
HUK62_05935	COG0784	Response regulator, receiver
HUK62_05935	COG0643	Histidine kinase
HUK62_05945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUK62_05950	COG5510	response to toxic substance
HUK62_05960	COG2832	Protein of unknown function (DUF454)
HUK62_06030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HUK62_06040	COG1289	transmembrane transporter activity
HUK62_06045	COG2814	Major facilitator Superfamily
HUK62_06060	COG0786	glutamate:sodium symporter activity
HUK62_06065	COG1115	amino acid carrier protein
HUK62_06075	COG1752	Esterase of the alpha-beta hydrolase superfamily
HUK62_06080	COG1607	acyl-coa hydrolase
HUK62_06090	COG0523	cobalamin synthesis protein
HUK62_06095	COG4681	YaeQ
HUK62_06120	COG0456	acetyltransferase
HUK62_06160	COG0477	Major facilitator Superfamily
HUK62_06165	COG0242	peptide deformylase activity
HUK62_06170	COG2207	Transcriptional regulator
HUK62_06175	COG2223	nitrite transmembrane transporter activity
HUK62_06215	COG0306	phosphate transporter
HUK62_06275	COG3293	Transposase
HUK62_06280	COG4181	ATPase activity
HUK62_06285	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HUK62_06305	COG0583	DNA-binding transcription factor activity
HUK62_06315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUK62_06320	COG1773	rubredoxin
HUK62_06325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUK62_06360	COG1695	Transcriptional regulator
HUK62_06375	COG3321	synthase
HUK62_06375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUK62_06375	COG0604	alcohol dehydrogenase
HUK62_06375	COG4221	oxidoreductase activity
HUK62_06415	COG0477	Major facilitator Superfamily
HUK62_06435	COG1597	lipid kinase activity
HUK62_06460	COG3119	arylsulfatase activity
HUK62_06485	COG0742	ribosomal rna small subunit methyltransferase
HUK62_06490	COG0768	penicillin binding
HUK62_06515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUK62_06520	COG2878	Part of a membrane complex involved in electron transport
HUK62_06525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUK62_06535	COG3384	dioxygenase
HUK62_06545	COG2234	aminopeptidase activity
HUK62_06560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUK62_06570	COG2217	Heavy metal translocating P-type atpase
HUK62_06575	COG0583	DNA-binding transcription factor activity
HUK62_06580	COG1914	H( )-stimulated, divalent metal cation uptake system
HUK62_06600	COG4770	biotin carboxylase activity
HUK62_06625	COG0006	proline dipeptidase activity
HUK62_06650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUK62_06655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUK62_06675	COG2915	High frequency lysogenization protein hflD homolog
HUK62_06690	COG4589	Belongs to the CDS family
HUK62_06705	COG2453	phosphatase
HUK62_06705	COG0671	phosphoesterase, PA-phosphatase related
HUK62_06710	COG2267	carboxylic ester hydrolase activity
HUK62_06730	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HUK62_06735	COG1686	Belongs to the peptidase S11 family
HUK62_06755	COG0753	catalase activity
HUK62_06770	COG4942	peptidase
HUK62_06770	COG1388	LysM domain
HUK62_06775	COG0583	DNA-binding transcription factor activity
HUK62_06810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUK62_06815	COG1388	LysM domain
HUK62_06815	COG0741	lytic transglycosylase activity
HUK62_06820	COG4166	transmembrane transport
HUK62_06825	COG4174	ABC transporter (Permease)
HUK62_06830	COG4239	(ABC) transporter, permease
HUK62_06835	COG4172	Belongs to the ABC transporter superfamily
HUK62_06850	COG2801	Transposase and inactivated derivatives
HUK62_06855	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HUK62_06880	COG0833	amino acid
HUK62_06905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUK62_06910	COG0418	dihydroorotase activity
HUK62_06915	COG5001	Diguanylate cyclase
HUK62_06915	COG3706	GGDEF domain
HUK62_06915	COG2203	Gaf domain
HUK62_06915	COG4251	negative regulation of phosphorylation
HUK62_06930	COG2186	Transcriptional regulator
HUK62_06940	COG0277	FAD linked oxidase domain protein
HUK62_06945	COG1902	pentaerythritol trinitrate reductase activity
HUK62_06945	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUK62_06960	COG0583	DNA-binding transcription factor activity
HUK62_06985	COG0281	malic enzyme
HUK62_06985	COG0280	phosphate acetyltransferase
HUK62_06995	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUK62_07000	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HUK62_07005	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUK62_07050	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUK62_07055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUK62_07070	COG1671	Belongs to the UPF0178 family
HUK62_07085	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUK62_07090	COG1136	(ABC) transporter
HUK62_07095	COG2333	competence protein COMEC
HUK62_07095	COG0658	competence protein
HUK62_07115	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HUK62_07120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUK62_07125	COG0628	permease
HUK62_07130	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUK62_07170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUK62_07190	COG0823	Involved in the tonB-independent uptake of proteins
HUK62_07210	COG0824	Thioesterase
HUK62_07215	COG1473	amidohydrolase
HUK62_07225	COG2255	four-way junction helicase activity
HUK62_07230	COG0632	four-way junction helicase activity
HUK62_07240	COG0047	phosphoribosylformylglycinamidine synthase activity
HUK62_07240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUK62_07250	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUK62_07250	COG3323	Protein of unknown function (DUF1653)
HUK62_07255	COG0778	Nitroreductase
HUK62_07260	COG1024	Enoyl-CoA hydratase
HUK62_07265	COG1051	belongs to the nudix hydrolase family
HUK62_07265	COG1056	cytidyltransferase-related domain
HUK62_07270	COG2353	YceI-like domain
HUK62_07275	COG0583	DNA-binding transcription factor activity
HUK62_07285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUK62_07300	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HUK62_07305	COG0602	queuosine metabolic process
HUK62_07325	COG0583	DNA-binding transcription factor activity
HUK62_07330	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HUK62_07335	COG4208	sulfate ABC transporter
HUK62_07350	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HUK62_07360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUK62_07380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUK62_07390	COG0481	GTPase activity
HUK62_07395	COG0681	Belongs to the peptidase S26 family
HUK62_07410	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUK62_07420	COG1381	Involved in DNA repair and RecF pathway recombination
HUK62_07425	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HUK62_07465	COG3293	Transposase
HUK62_07470	COG0436	Aminotransferase
HUK62_07495	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUK62_07495	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUK62_07500	COG1254	Belongs to the acylphosphatase family
HUK62_07505	COG1047	Peptidyl-prolyl cis-trans
HUK62_07510	COG1252	NADH dehydrogenase
HUK62_07515	COG1686	Belongs to the peptidase S11 family
HUK62_07525	COG2351	hydroxyisourate hydrolase activity
HUK62_07580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUK62_07595	COG0612	Peptidase, M16
HUK62_07630	COG0352	thiamine-phosphate diphosphorylase activity
HUK62_07680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUK62_07685	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HUK62_07700	COG2353	YceI-like domain
HUK62_07705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUK62_07705	COG0519	Catalyzes the synthesis of GMP from XMP
HUK62_07715	COG1028	Short-chain dehydrogenase reductase Sdr
HUK62_07725	COG4302	ethanolamine ammonia-lyase activity
HUK62_07730	COG4303	Ethanolamine ammonia lyase large subunit
HUK62_07735	COG0531	amino acid
HUK62_07755	COG1454	alcohol dehydrogenase
HUK62_07765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUK62_07770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUK62_07775	COG2814	Major facilitator Superfamily
HUK62_07785	COG2707	UPF0756 membrane protein
HUK62_07790	COG1187	pseudouridine synthase activity
HUK62_07810	COG0802	atpase or kinase
HUK62_07815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUK62_07825	COG1923	regulation of RNA biosynthetic process
HUK62_07830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUK62_07840	COG3178	'Phosphotransferase
HUK62_07845	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUK62_07855	COG1192	Involved in chromosome partitioning
HUK62_07860	COG1475	DNA binding
HUK62_07865	COG0811	peptide transport
HUK62_07875	COG1132	(ABC) transporter
HUK62_07880	COG1663	tetraacyldisaccharide 4'-kinase activity
HUK62_07900	COG0084	hydrolase, TatD family'
HUK62_07935	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUK62_07945	COG0590	tRNA wobble adenosine to inosine editing
HUK62_07965	COG0776	regulation of translation
HUK62_07980	COG2431	L-lysine efflux transmembrane transporter activity
HUK62_07995	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HUK62_08000	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HUK62_08020	COG1253	flavin adenine dinucleotide binding
HUK62_08045	COG0308	aminopeptidase N
HUK62_08055	COG0589	response to stress
HUK62_08070	COG2076	Multidrug Resistance protein
HUK62_08075	COG1309	transcriptional regulator
HUK62_08080	COG3135	benzoate transporter
HUK62_08090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUK62_08135	COG4372	Transposase
HUK62_08140	COG0183	Belongs to the thiolase family
HUK62_08145	COG1028	Short-chain dehydrogenase reductase Sdr
HUK62_08165	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUK62_08170	COG0824	Thioesterase
HUK62_08175	COG1454	alcohol dehydrogenase
HUK62_08180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUK62_08200	COG0069	glutamate synthase activity
HUK62_08205	COG2197	response regulator
HUK62_08210	COG4585	Histidine kinase
HUK62_08215	COG2850	peptidyl-arginine hydroxylation
HUK62_08225	COG0424	maF-like protein
HUK62_08235	COG0126	phosphoglycerate kinase activity
HUK62_08250	COG0697	spore germination
HUK62_08280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUK62_08285	COG3781	membrane
HUK62_08315	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HUK62_08315	COG0506	proline dehydrogenase activity
HUK62_08315	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HUK62_08325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUK62_08335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUK62_08365	COG0316	Belongs to the HesB IscA family
HUK62_08370	COG0822	iron-sulfur transferase activity
HUK62_08380	COG1959	2 iron, 2 sulfur cluster binding
HUK62_08395	COG0776	regulation of translation
HUK62_08400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUK62_08425	COG0537	adenosine 5'-monophosphoramidase activity
HUK62_08460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUK62_08465	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HUK62_08480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUK62_08490	COG0133	tryptophan synthase activity
HUK62_08495	COG0517	IMP dehydrogenase activity
HUK62_08520	COG0612	Peptidase, M16
HUK62_08525	COG0552	protein localization to endoplasmic reticulum
HUK62_08580	COG1960	acyl-CoA dehydrogenase activity
HUK62_08655	COG2814	Major facilitator Superfamily
HUK62_08685	COG0864	Transcriptional regulator
HUK62_08770	COG0596	Alpha beta hydrolase
HUK62_08860	COG2801	Transposase and inactivated derivatives
HUK62_08975	COG2814	Major facilitator Superfamily
HUK62_08980	COG0583	DNA-binding transcription factor activity
HUK62_08985	COG4948	Mandelate Racemase Muconate Lactonizing
HUK62_08990	COG4829	muconolactone delta-isomerase
HUK62_09000	COG4638	Rieske (2fe-2S)
HUK62_09005	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HUK62_09010	COG0543	2 iron, 2 sulfur cluster binding
HUK62_09010	COG0633	Ferredoxin
HUK62_09015	COG1028	Short-chain dehydrogenase reductase Sdr
HUK62_09020	COG3135	benzoate transporter
HUK62_09025	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HUK62_09030	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HUK62_09035	COG0183	Belongs to the thiolase family
HUK62_09040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUK62_09050	COG0511	ligase activity, forming carbon-carbon bonds
HUK62_09065	COG0439	Biotin carboxylase
HUK62_09080	COG0583	DNA-binding transcription factor activity
HUK62_09085	COG0183	Belongs to the thiolase family
HUK62_09095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUK62_09115	COG0251	oxidation-reduction process
HUK62_09120	COG1335	isochorismatase
HUK62_09125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUK62_09130	COG0596	Alpha beta hydrolase
HUK62_09145	COG0640	Transcriptional regulator
HUK62_09165	COG3122	Protein conserved in bacteria
HUK62_09170	COG0668	transmembrane transport
HUK62_09225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUK62_09245	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HUK62_09250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUK62_09345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUK62_09350	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HUK62_09375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUK62_09380	COG0583	DNA-binding transcription factor activity
HUK62_09385	COG1380	Effector of murein hydrolase LrgA
HUK62_09390	COG1346	cytolysis
HUK62_09405	COG2223	nitrite transmembrane transporter activity
HUK62_09435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUK62_09440	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUK62_09445	COG2207	Transcriptional regulator
HUK62_09450	COG1944	ATP diphosphatase activity
HUK62_09455	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUK62_09470	COG3293	Transposase
HUK62_09480	COG0730	response to heat
HUK62_09485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUK62_09550	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HUK62_09560	COG3293	Transposase
HUK62_09630	COG1484	DNA-dependent DNA replication
HUK62_09645	COG3706	GGDEF domain
HUK62_09650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUK62_09655	COG0183	Belongs to the thiolase family
HUK62_09670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUK62_09675	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HUK62_09680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUK62_09695	COG1484	DNA-dependent DNA replication
HUK62_09775	COG0204	Acyl-transferase
HUK62_09815	COG1464	Belongs to the NlpA lipoprotein family
HUK62_09840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUK62_09855	COG0012	GTP binding
HUK62_09880	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HUK62_09895	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUK62_09910	COG0386	Belongs to the glutathione peroxidase family
HUK62_09915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUK62_09920	COG0436	Aminotransferase
HUK62_09940	COG3634	alkyl hydroperoxide reductase activity
HUK62_09965	COG2070	2-Nitropropane dioxygenase
HUK62_10005	COG1278	Cold shock
HUK62_10100	COG1309	transcriptional regulator
HUK62_10125	COG0842	Transport permease protein
HUK62_10130	COG0842	Transport permease protein
HUK62_10135	COG1131	(ABC) transporter
HUK62_10175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUK62_10205	COG0745	RESPONSE REGULATOR receiver
HUK62_10210	COG0642	Histidine kinase
HUK62_10225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUK62_10260	COG2816	NAD+ diphosphatase activity
HUK62_10265	COG3046	protein related to deoxyribodipyrimidine photolyase
HUK62_10280	COG2351	hydroxyisourate hydrolase activity
HUK62_10325	COG3293	Transposase
HUK62_10400	COG0714	Associated with various cellular activities
HUK62_10405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUK62_10410	COG2879	small protein
HUK62_10415	COG1966	Carbon starvation protein
HUK62_10420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUK62_10440	COG0254	rRNA binding
HUK62_10460	COG1067	ATP-dependent peptidase activity
HUK62_10465	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HUK62_10470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUK62_10475	COG0616	signal peptide processing
HUK62_10480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUK62_10490	COG0573	inorganic phosphate transmembrane transporter activity
HUK62_10495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUK62_10500	COG0076	glutamate decarboxylase activity
HUK62_10505	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUK62_10530	COG0671	phosphoesterase, PA-phosphatase related
HUK62_10535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUK62_10545	COG1733	regulation of RNA biosynthetic process
HUK62_10550	COG0702	epimerase
HUK62_10580	COG0556	nucleotide-excision repair
HUK62_10590	COG3293	Transposase
HUK62_10610	COG0318	PFAM AMP-dependent synthetase and ligase
HUK62_10620	COG2819	hydrolase of the alpha beta superfamily
HUK62_10630	COG0372	Belongs to the citrate synthase family
HUK62_10660	COG0542	response to heat
HUK62_10665	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUK62_10680	COG3706	GGDEF domain
HUK62_10690	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HUK62_10695	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUK62_10705	COG0569	domain protein
HUK62_10710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUK62_10730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUK62_10740	COG1585	Membrane protein implicated in regulation of membrane protease activity
HUK62_10755	COG1294	oxidase, subunit
HUK62_10760	COG4890	Cyd operon protein YbgT
HUK62_10775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUK62_10780	COG1309	transcriptional regulator
HUK62_10785	COG1012	belongs to the aldehyde dehydrogenase family
HUK62_10795	COG0579	oxidoreductase
HUK62_10810	COG0772	Belongs to the SEDS family
HUK62_10830	COG0148	phosphopyruvate hydratase activity
HUK62_10850	COG0583	DNA-binding transcription factor activity
HUK62_10855	COG0656	L-ascorbic acid biosynthetic process
HUK62_10880	COG1902	pentaerythritol trinitrate reductase activity
HUK62_10880	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUK62_10890	COG2267	carboxylic ester hydrolase activity
HUK62_10900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUK62_10905	COG0702	epimerase
HUK62_10945	COG1011	Hydrolase
HUK62_10950	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HUK62_10955	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUK62_10960	COG2137	regulation of response to DNA damage stimulus
HUK62_10975	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUK62_10995	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUK62_11010	COG0575	Belongs to the CDS family
HUK62_11015	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUK62_11035	COG3852	Histidine kinase
HUK62_11050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUK62_11055	COG0583	DNA-binding transcription factor activity
HUK62_11060	COG0024	Methionine aminopeptidase
HUK62_11090	COG1113	amino acid transport
HUK62_11140	COG0729	surface antigen
HUK62_11170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUK62_11235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUK62_11240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUK62_11245	COG2890	protein-(glutamine-N5) methyltransferase activity
HUK62_11250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUK62_11265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUK62_11300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUK62_11305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUK62_11310	COG1845	cytochrome c oxidase, subunit III
HUK62_11315	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HUK62_11335	COG0360	Binds together with S18 to 16S ribosomal RNA
HUK62_11350	COG0305	Participates in initiation and elongation during chromosome replication
HUK62_11355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUK62_11370	COG1305	Transglutaminase-like
HUK62_11380	COG2308	Evidence 4 Homologs of previously reported genes of
HUK62_11395	COG0445	tRNA wobble uridine modification
HUK62_11425	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HUK62_11430	COG0138	bifunctional purine biosynthesis protein purh
HUK62_11435	COG0151	Belongs to the GarS family
HUK62_11445	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUK62_11455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUK62_11460	COG2011	ABC-type metal ion transport system permease component
HUK62_11500	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HUK62_11510	COG4122	O-methyltransferase activity
HUK62_11530	COG1137	ATPase activity
HUK62_11535	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HUK62_11545	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HUK62_11550	COG0517	IMP dehydrogenase activity
HUK62_11550	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUK62_11560	COG0406	alpha-ribazole phosphatase activity
HUK62_11565	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUK62_11600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUK62_11610	COG0243	molybdopterin cofactor binding
HUK62_11615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUK62_11620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUK62_11625	COG2223	nitrite transmembrane transporter activity
HUK62_11635	COG1116	anion transmembrane transporter activity
HUK62_11635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUK62_11655	COG1643	Atp-dependent helicase
HUK62_11665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUK62_11705	COG0515	serine threonine protein kinase
HUK62_11705	COG2815	serine threonine protein kinase
HUK62_11735	COG1610	YqeY-like protein
HUK62_11740	COG4783	chaperone-mediated protein folding
HUK62_11795	COG0778	Nitroreductase
HUK62_11805	COG0513	Belongs to the DEAD box helicase family
HUK62_11810	COG1278	Cold shock
HUK62_11825	COG2363	Small membrane protein
HUK62_11850	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUK62_11855	COG0625	glutathione transferase activity
HUK62_11860	COG0659	secondary active sulfate transmembrane transporter activity
HUK62_11870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUK62_11905	COG0318	PFAM AMP-dependent synthetase and ligase
HUK62_11910	COG1309	transcriptional regulator
HUK62_11915	COG1960	acyl-CoA dehydrogenase activity
HUK62_11930	COG4770	biotin carboxylase activity
HUK62_11945	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HUK62_11950	COG2031	fatty acid transporter
HUK62_11980	COG0540	Belongs to the ATCase OTCase family
HUK62_12005	COG1765	OsmC-like protein
HUK62_12015	COG0667	Aldo Keto reductase
HUK62_12030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUK62_12045	COG1522	sequence-specific DNA binding
HUK62_12050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HUK62_12065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUK62_12075	COG0527	aspartate kinase activity
HUK62_12085	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUK62_12110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUK62_12115	COG2252	PERMEase
HUK62_12125	COG0415	Belongs to the DNA photolyase family
HUK62_12155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUK62_12160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUK62_12170	COG0693	protein deglycase activity
HUK62_12175	COG1960	acyl-CoA dehydrogenase activity
HUK62_12180	COG1301	dicarboxylic acid transport
HUK62_12185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUK62_12185	COG0512	Glutamine amidotransferase of anthranilate synthase
HUK62_12195	COG4372	Transposase
HUK62_12215	COG3139	Protein of unknown function (DUF1315)
HUK62_12220	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUK62_12225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUK62_12235	COG0494	nUDIX hydrolase
HUK62_12245	COG0642	Histidine kinase
HUK62_12250	COG0745	RESPONSE REGULATOR receiver
HUK62_12260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUK62_12280	COG1720	tRNA m6t6A37 methyltransferase activity
HUK62_12400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUK62_12405	COG3634	alkyl hydroperoxide reductase activity
HUK62_12425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUK62_12470	COG0431	NADPH-dependent FMN reductase
HUK62_12475	COG0798	PFAM Bile acid sodium symporter
HUK62_12485	COG0640	Transcriptional regulator
HUK62_12510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUK62_12535	COG0640	Transcriptional regulator
HUK62_12545	COG1136	(ABC) transporter
HUK62_12555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUK62_12605	COG3676	manually curated
HUK62_12670	COG1696	Membrane protein involved in D-alanine export
HUK62_12715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUK62_12735	COG3077	Addiction module antitoxin, RelB DinJ family
HUK62_12805	COG0582	viral genome integration into host DNA
HUK62_12815	COG1131	(ABC) transporter
HUK62_12820	COG0842	Transport permease protein
HUK62_12835	COG2951	lytic endotransglycosylase activity
HUK62_12870	COG0052	Belongs to the universal ribosomal protein uS2 family
HUK62_12890	COG2175	clavaminate synthase activity
HUK62_12915	COG0842	Transport permease protein
HUK62_12950	COG1280	lysine exporter protein (LysE YggA)
HUK62_12955	COG1522	sequence-specific DNA binding
HUK62_12960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUK62_12970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HUK62_12980	COG0019	diaminopimelate decarboxylase activity
HUK62_12990	COG1113	amino acid transport
HUK62_12995	COG1115	amino acid carrier protein
HUK62_13010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUK62_13015	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUK62_13020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUK62_13025	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUK62_13065	COG4372	Transposase
HUK62_13090	COG1538	Outer membrane efflux protein
HUK62_13140	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUK62_13145	COG3161	chorismate lyase activity
HUK62_13155	COG0174	glutamine synthetase
HUK62_13160	COG0512	Glutamine amidotransferase of anthranilate synthase
HUK62_13165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUK62_13170	COG0134	indole-3-glycerol-phosphate synthase activity
HUK62_13205	COG0302	gtp cyclohydrolase
HUK62_13215	COG3706	GGDEF domain
HUK62_13230	COG3739	integral membrane protein
HUK62_13250	COG1741	Belongs to the pirin family
HUK62_13265	COG1309	transcriptional regulator
HUK62_13275	COG5006	permease, DMT superfamily
HUK62_13300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUK62_13305	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HUK62_13315	COG0037	tRNA processing
HUK62_13320	COG0741	lytic transglycosylase activity
HUK62_13325	COG0501	Belongs to the peptidase M48B family
HUK62_13340	COG2239	Acts as a magnesium transporter
HUK62_13370	COG1253	flavin adenine dinucleotide binding
HUK62_13375	COG2851	Citrate transporter
HUK62_13415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUK62_13420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUK62_13445	COG0505	Belongs to the CarA family
HUK62_13450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUK62_13475	COG3695	enzyme binding
HUK62_13490	COG2321	neutral zinc metallopeptidase
HUK62_13495	COG2354	Protein conserved in bacteria
HUK62_13505	COG1585	Membrane protein implicated in regulation of membrane protease activity
HUK62_13525	COG2433	Pfam Transposase IS66
HUK62_13540	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HUK62_13550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUK62_13565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUK62_13570	COG1053	succinate dehydrogenase
HUK62_13575	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HUK62_13580	COG2009	succinate dehydrogenase
HUK62_13595	COG0300	oxidoreductase activity
HUK62_13610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUK62_13610	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUK62_13635	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUK62_13660	COG0564	pseudouridine synthase activity
HUK62_13670	COG0358	DNA primase activity
HUK62_13685	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HUK62_13715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUK62_13720	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUK62_13775	COG0586	Pfam SNARE associated Golgi protein
HUK62_13810	COG2921	Belongs to the UPF0250 family
HUK62_13815	COG0321	lipoyl(octanoyl) transferase activity
HUK62_13830	COG0531	amino acid
HUK62_13850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HUK62_13855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUK62_13855	COG1648	precorrin-2 dehydrogenase activity
HUK62_13860	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUK62_13870	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HUK62_13885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUK62_13905	COG0671	phosphoesterase, PA-phosphatase related
HUK62_13910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUK62_13920	COG1538	Outer membrane efflux protein
HUK62_13925	COG0393	Putative heavy-metal-binding
HUK62_13940	COG1028	Short-chain dehydrogenase reductase Sdr
HUK62_13950	COG0525	valine-tRNA ligase activity
HUK62_13985	COG0583	DNA-binding transcription factor activity
HUK62_13990	COG1278	Cold shock
HUK62_13995	COG1278	Cold shock
HUK62_14010	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUK62_14015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUK62_14020	COG0713	ATP synthesis coupled electron transport
HUK62_14030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUK62_14045	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUK62_14075	COG2205	protein histidine kinase activity
HUK62_14080	COG0745	RESPONSE REGULATOR receiver
HUK62_14095	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUK62_14140	COG3501	Rhs element vgr protein
HUK62_14150	COG0439	Biotin carboxylase
HUK62_14155	COG1802	Transcriptional regulator
HUK62_14160	COG1652	LysM domain
HUK62_14170	COG1028	Short-chain dehydrogenase reductase Sdr
HUK62_14185	COG1399	metal-binding, possibly nucleic acid-binding protein
HUK62_14190	COG3101	peptidyl-lysine hydroxylation
HUK62_14195	COG0009	L-threonylcarbamoyladenylate synthase
HUK62_14210	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUK62_14215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUK62_14260	COG4106	trans-aconitate 2-methyltransferase activity
HUK62_14275	COG2226	methyltransferase
HUK62_14275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUK62_14275	COG0596	Alpha beta hydrolase
HUK62_14280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUK62_14285	COG2193	ferroxidase activity
HUK62_14310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUK62_14315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUK62_14320	COG3115	cell septum assembly
HUK62_14325	COG1196	nuclear chromosome segregation
HUK62_14335	COG0730	response to heat
HUK62_14355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUK62_14435	COG3422	double-strand break repair
HUK62_14445	COG2824	Alkylphosphonate utilization operon protein PhnA
HUK62_14450	COG3189	MarR family transcriptional regulator
HUK62_14470	COG0564	pseudouridine synthase activity
HUK62_14475	COG0346	lactoylglutathione lyase activity
HUK62_14515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUK62_14545	COG1902	pentaerythritol trinitrate reductase activity
HUK62_14570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUK62_14585	COG1970	mechanosensitive ion channel activity
HUK62_14595	COG2233	PERMEase
HUK62_14600	COG2813	Specifically methylates the guanine in position
HUK62_14605	COG0833	amino acid
HUK62_14620	COG0183	Belongs to the thiolase family
HUK62_14640	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUK62_14655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUK62_14660	COG2207	Transcriptional regulator
HUK62_14665	COG0183	Belongs to the thiolase family
HUK62_14670	COG1024	Enoyl-CoA hydratase
HUK62_14670	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUK62_14690	COG1272	protein, Hemolysin III
HUK62_14695	COG0477	Major facilitator Superfamily
HUK62_14705	COG1408	metallophosphoesterase
HUK62_14710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUK62_14720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUK62_14745	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUK62_14750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUK62_14755	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HUK62_14760	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUK62_14765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUK62_14775	COG0625	glutathione transferase activity
HUK62_14780	COG2969	positive regulation of protein catabolic process
HUK62_14845	COG2199	diguanylate cyclase activity
HUK62_14875	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUK62_14880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUK62_14900	COG0450	alkyl hydroperoxide reductase
HUK62_14920	COG0285	dihydrofolate synthase activity
HUK62_14950	COG3083	sulfuric ester hydrolase activity
HUK62_14980	COG4206	TonB-dependent receptor
HUK62_14985	COG2096	Adenosyltransferase
HUK62_15005	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HUK62_15010	COG2315	Protein conserved in bacteria
HUK62_15020	COG1113	amino acid transport
HUK62_15025	COG0745	RESPONSE REGULATOR receiver
HUK62_15030	COG2205	protein histidine kinase activity
HUK62_15040	COG1960	acyl-CoA dehydrogenase activity
HUK62_15045	COG1960	acyl-CoA dehydrogenase activity
HUK62_15050	COG3223	Belongs to the PsiE family
HUK62_15085	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUK62_15105	COG0463	Glycosyl transferase, family 2
HUK62_15110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUK62_15140	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HUK62_15160	COG0438	transferase activity, transferring glycosyl groups
HUK62_15190	COG2826	transposase and inactivated derivatives, IS30 family
HUK62_15200	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HUK62_15205	COG5002	protein histidine kinase activity
HUK62_15215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUK62_15225	COG1704	LemA family
HUK62_15235	COG1862	Preprotein translocase
HUK62_15275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUK62_15295	COG1426	Protein conserved in bacteria
HUK62_15355	COG0440	acetolactate synthase activity
HUK62_15360	COG0028	Belongs to the TPP enzyme family
HUK62_15385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUK62_15390	COG0577	efflux transmembrane transporter activity
HUK62_15390	COG1136	(ABC) transporter
HUK62_15395	COG1538	Outer membrane efflux protein
HUK62_15415	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HUK62_15420	COG1162	GTPase activity
HUK62_15445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUK62_15455	COG3781	membrane
HUK62_15460	COG0613	PHP domain protein
HUK62_15470	COG2350	Protein conserved in bacteria
HUK62_15490	COG1666	GTP binding
HUK62_15510	COG1607	acyl-coa hydrolase
HUK62_15570	COG1183	phosphatidylcholine synthase activity
HUK62_15575	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HUK62_15600	COG0039	L-malate dehydrogenase activity
HUK62_15610	COG1196	nuclear chromosome segregation
HUK62_15610	COG0741	lytic transglycosylase activity
HUK62_15610	COG0739	heme binding
HUK62_15615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUK62_15620	COG1702	phosphate starvation-inducible protein PhoH
HUK62_15625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUK62_15670	COG1295	ribonuclease BN
HUK62_15685	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUK62_15715	COG0557	exoribonuclease II activity
HUK62_15720	COG2720	vancomycin resistance protein
HUK62_15725	COG0339	signal peptide processing
HUK62_15730	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HUK62_15765	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HUK62_15770	COG1960	acyl-CoA dehydrogenase activity
HUK62_15795	COG0203	ribosomal protein L17
HUK62_15800	COG0202	RNA polymerase activity
HUK62_15815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUK62_15840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUK62_15850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUK62_15855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUK62_15905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUK62_15920	COG0088	Forms part of the polypeptide exit tunnel
HUK62_15925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUK62_15945	COG0433	COG0433 Predicted ATPase
HUK62_15955	COG1959	2 iron, 2 sulfur cluster binding
HUK62_15970	COG1301	dicarboxylic acid transport
HUK62_15975	COG1946	Acyl-CoA thioesterase
HUK62_15980	COG2937	Belongs to the GPAT DAPAT family
HUK62_15990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUK62_15995	COG1040	competence protein
HUK62_16000	COG0494	nUDIX hydrolase
HUK62_16010	COG0598	Magnesium transport protein CorA
HUK62_16020	COG2854	intermembrane phospholipid transfer
HUK62_16025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HUK62_16030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUK62_16035	COG1127	ABC transporter
HUK62_16040	COG0513	Belongs to the DEAD box helicase family
HUK62_16060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUK62_16085	COG1960	acyl-CoA dehydrogenase activity
HUK62_16090	COG1910	domain protein
HUK62_16110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUK62_16120	COG0534	Mate efflux family protein
HUK62_16130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUK62_16135	COG0254	rRNA binding
HUK62_16140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUK62_16155	COG2226	methyltransferase
HUK62_16165	COG1192	Involved in chromosome partitioning
HUK62_16170	COG0628	permease
HUK62_16175	COG2032	superoxide dismutase activity
HUK62_16180	COG1289	transmembrane transporter activity
HUK62_16185	COG2814	Major facilitator Superfamily
HUK62_16220	COG0277	FAD linked oxidase domain protein
HUK62_16225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUK62_16230	COG5006	permease, DMT superfamily
HUK62_16235	COG5006	permease, DMT superfamily
HUK62_16250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUK62_16255	COG5380	lipid catabolic process
HUK62_16285	COG0335	large ribosomal subunit rRNA binding
HUK62_16295	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUK62_16300	COG0228	four-way junction DNA binding
HUK62_16315	COG0194	GDP metabolic process
HUK62_16320	COG1758	RNA polymerase activity
HUK62_16325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUK62_16365	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HUK62_16370	COG1704	LemA family
HUK62_16380	COG0493	'glutamate synthase
HUK62_16385	COG0069	glutamate synthase activity
HUK62_16385	COG0067	glutamate synthase
HUK62_16385	COG0070	glutamate synthase
HUK62_16445	COG2226	methyltransferase
HUK62_16455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUK62_16460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUK62_16480	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HUK62_16510	COG4372	Transposase
HUK62_16550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUK62_16570	COG0488	(ABC) transporter
HUK62_16580	COG4221	oxidoreductase activity
HUK62_16610	COG0745	RESPONSE REGULATOR receiver
HUK62_16615	COG2205	protein histidine kinase activity
HUK62_16620	COG0427	acetyl-CoA hydrolase
HUK62_16655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUK62_16690	COG1278	Cold shock
HUK62_16695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HUK62_16700	COG0107	imidazoleglycerol-phosphate synthase activity
HUK62_16720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUK62_16750	COG0582	viral genome integration into host DNA
HUK62_16780	COG3293	Transposase
HUK62_16815	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HUK62_16840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUK62_16860	COG0583	DNA-binding transcription factor activity
HUK62_16875	COG0629	single-stranded DNA binding
HUK62_16920	COG3293	Transposase
HUK62_16925	COG0629	single-stranded DNA binding
HUK62_16930	COG2814	Major facilitator Superfamily
HUK62_16940	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HUK62_16940	COG0352	thiamine-phosphate diphosphorylase activity
HUK62_16940	COG0351	phosphomethylpyrimidine kinase
HUK62_16960	COG3706	GGDEF domain
HUK62_16970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUK62_16985	COG3162	membrane
HUK62_17015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUK62_17135	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HUK62_17150	COG1396	sequence-specific DNA binding
HUK62_17190	COG2433	Pfam Transposase IS66
HUK62_17225	COG0753	catalase activity
HUK62_17235	COG3706	GGDEF domain
HUK62_17240	COG3077	Addiction module antitoxin, RelB DinJ family
HUK62_17260	COG1335	isochorismatase
HUK62_17265	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUK62_17295	COG4680	protein conserved in bacteria
HUK62_17300	COG1373	ATPase (AAA superfamily
HUK62_17315	COG0582	viral genome integration into host DNA
HUK62_17345	COG0640	Transcriptional regulator
HUK62_17425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUK62_17470	COG2194	sulfuric ester hydrolase activity
HUK62_17475	COG0745	RESPONSE REGULATOR receiver
HUK62_17480	COG0642	Histidine kinase
HUK62_17525	COG4372	Transposase
HUK62_17540	COG2132	Multicopper oxidase
HUK62_17560	COG2205	protein histidine kinase activity
HUK62_17565	COG3174	membrane
HUK62_17570	COG2217	Heavy metal translocating P-type atpase
HUK62_17635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUK62_17650	COG3038	cytochrome b561
HUK62_17665	COG0671	phosphoesterase, PA-phosphatase related
HUK62_17675	COG2194	sulfuric ester hydrolase activity
HUK62_17685	COG2194	sulfuric ester hydrolase activity
HUK62_17735	COG0659	secondary active sulfate transmembrane transporter activity
HUK62_17775	COG3293	Transposase
HUK62_17780	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUK62_17785	COG3657	addiction module killer protein
HUK62_17840	COG0515	serine threonine protein kinase
HUK62_17845	COG2116	formate transmembrane transporter activity
HUK62_17850	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HUK62_17885	COG1192	Involved in chromosome partitioning
HUK62_17890	COG1475	DNA binding
HUK62_17910	COG2814	Major facilitator Superfamily
HUK62_17915	COG0583	DNA-binding transcription factor activity
HUK62_17925	COG2026	Addiction module toxin, RelE StbE family
HUK62_17930	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HUK62_17950	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HUK62_17990	COG0745	RESPONSE REGULATOR receiver
HUK62_17995	COG0642	Histidine kinase
HUK62_18040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUK62_18045	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUK62_18075	COG2826	transposase and inactivated derivatives, IS30 family
HUK62_18130	COG0582	viral genome integration into host DNA
HUK62_18155	COG4372	Transposase
HUK62_18185	COG0471	metal ion transport
HUK62_18210	COG1764	response to oxidative stress
HUK62_18215	COG1846	Transcriptional regulator
HUK62_18235	COG0783	Belongs to the Dps family
HUK62_18265	COG4372	Transposase
HUK62_18360	COG1475	DNA binding
HUK62_18365	COG1192	Involved in chromosome partitioning
HUK62_18395	COG4716	Myosin-crossreactive antigen
HUK62_18440	COG0842	Transport permease protein
HUK62_18445	COG0842	Transport permease protein
HUK62_18445	COG1129	ABC transporter
HUK62_18450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUK62_18580	COG3077	Addiction module antitoxin, RelB DinJ family
HUK62_18825	COG0406	alpha-ribazole phosphatase activity