locus-tag	class	description
C3Y93_00005	COG0628	permease
C3Y93_00040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3Y93_00060	COG0823	Involved in the tonB-independent uptake of proteins
C3Y93_00080	COG0824	Thioesterase
C3Y93_00090	COG2255	four-way junction helicase activity
C3Y93_00095	COG0632	four-way junction helicase activity
C3Y93_00115	COG1024	Enoyl-CoA hydratase
C3Y93_00120	COG1051	belongs to the nudix hydrolase family
C3Y93_00120	COG1056	cytidyltransferase-related domain
C3Y93_00125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C3Y93_00135	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C3Y93_00150	COG4625	pathogenesis
C3Y93_00160	COG0583	DNA-binding transcription factor activity
C3Y93_00165	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C3Y93_00170	COG4208	sulfate ABC transporter
C3Y93_00185	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C3Y93_00195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C3Y93_00210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3Y93_00220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3Y93_00245	COG0571	ribonuclease III activity
C3Y93_00250	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C3Y93_00265	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C3Y93_00305	COG0556	nucleotide-excision repair
C3Y93_00325	COG1733	regulation of RNA biosynthetic process
C3Y93_00330	COG2814	Major facilitator Superfamily
C3Y93_00340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C3Y93_00355	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C3Y93_00360	COG0076	glutamate decarboxylase activity
C3Y93_00370	COG0573	inorganic phosphate transmembrane transporter activity
C3Y93_00380	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C3Y93_00390	COG0616	signal peptide processing
C3Y93_00410	COG2915	High frequency lysogenization protein hflD homolog
C3Y93_00430	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C3Y93_00435	COG1686	Belongs to the peptidase S11 family
C3Y93_00460	COG0583	DNA-binding transcription factor activity
C3Y93_00465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3Y93_00470	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C3Y93_00475	COG1067	ATP-dependent peptidase activity
C3Y93_00510	COG1509	lysine 2,3-aminomutase activity
C3Y93_00515	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C3Y93_00520	COG1966	Carbon starvation protein
C3Y93_00525	COG2879	small protein
C3Y93_00530	COG0714	Associated with various cellular activities
C3Y93_00560	COG2252	PERMEase
C3Y93_00565	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C3Y93_00580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C3Y93_00590	COG0527	aspartate kinase activity
C3Y93_00595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C3Y93_00600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C3Y93_00615	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C3Y93_00630	COG0667	Aldo Keto reductase
C3Y93_00640	COG1765	OsmC-like protein
C3Y93_00665	COG0540	Belongs to the ATCase OTCase family
C3Y93_00685	COG2885	chlorophyll binding
C3Y93_00685	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C3Y93_00690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C3Y93_00710	COG1024	Enoyl-CoA hydratase
C3Y93_00715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3Y93_00720	COG1960	acyl-CoA dehydrogenase activity
C3Y93_00725	COG1309	transcriptional regulator
C3Y93_00730	COG0318	PFAM AMP-dependent synthetase and ligase
C3Y93_00755	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C3Y93_00760	COG0659	secondary active sulfate transmembrane transporter activity
C3Y93_00780	COG2363	Small membrane protein
C3Y93_00795	COG1278	Cold shock
C3Y93_00800	COG0513	Belongs to the DEAD box helicase family
C3Y93_00815	COG0778	Nitroreductase
C3Y93_00840	COG0167	dihydroorotate dehydrogenase activity
C3Y93_00845	COG1286	toxin biosynthetic process
C3Y93_00870	COG4783	chaperone-mediated protein folding
C3Y93_00885	COG1610	YqeY-like protein
C3Y93_00890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C3Y93_00920	COG2815	serine threonine protein kinase
C3Y93_00920	COG0515	serine threonine protein kinase
C3Y93_00955	COG0436	Aminotransferase
C3Y93_00960	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3Y93_00965	COG0386	Belongs to the glutathione peroxidase family
C3Y93_00975	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C3Y93_00980	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C3Y93_00990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C3Y93_01000	COG0012	GTP binding
C3Y93_01035	COG0582	viral genome integration into host DNA
C3Y93_01070	COG3293	Transposase
C3Y93_01095	COG3293	Transposase
C3Y93_01155	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C3Y93_01165	COG2826	transposase and inactivated derivatives, IS30 family
C3Y93_01240	COG2274	protein secretion by the type I secretion system
C3Y93_01250	COG4372	Transposase
C3Y93_01260	COG2963	transposase activity
C3Y93_01265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C3Y93_01285	COG2816	NAD+ diphosphatase activity
C3Y93_01310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C3Y93_01325	COG0642	Histidine kinase
C3Y93_01360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3Y93_01400	COG1012	belongs to the aldehyde dehydrogenase family
C3Y93_01405	COG1309	transcriptional regulator
C3Y93_01410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C3Y93_01440	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C3Y93_01470	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C3Y93_01470	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C3Y93_01510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C3Y93_01515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C3Y93_01525	COG2353	YceI-like domain
C3Y93_01530	COG0519	Catalyzes the synthesis of GMP from XMP
C3Y93_01530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3Y93_01550	COG1454	alcohol dehydrogenase
C3Y93_01560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3Y93_01565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3Y93_01570	COG0583	DNA-binding transcription factor activity
C3Y93_01575	COG2807	transmembrane transport
C3Y93_01580	COG2707	UPF0756 membrane protein
C3Y93_01605	COG0802	atpase or kinase
C3Y93_01610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C3Y93_01620	COG1923	regulation of RNA biosynthetic process
C3Y93_01625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3Y93_01640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C3Y93_01650	COG1192	Involved in chromosome partitioning
C3Y93_01655	COG1475	DNA binding
C3Y93_01660	COG0811	peptide transport
C3Y93_01670	COG1132	(ABC) transporter
C3Y93_01675	COG1663	tetraacyldisaccharide 4'-kinase activity
C3Y93_01695	COG0084	hydrolase, TatD family'
C3Y93_01730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C3Y93_01740	COG0590	tRNA wobble adenosine to inosine editing
C3Y93_01775	COG2431	L-lysine efflux transmembrane transporter activity
C3Y93_01790	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C3Y93_01795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C3Y93_01830	COG1253	flavin adenine dinucleotide binding
C3Y93_01850	COG1114	Component of the transport system for branched-chain amino acids
C3Y93_01855	COG0024	Methionine aminopeptidase
C3Y93_01860	COG0583	DNA-binding transcription factor activity
C3Y93_01865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3Y93_01880	COG3852	Histidine kinase
C3Y93_01905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3Y93_01910	COG0575	Belongs to the CDS family
C3Y93_01925	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C3Y93_01935	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3Y93_01945	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3Y93_01950	COG4372	Transposase
C3Y93_01960	COG2963	transposase activity
C3Y93_01975	COG2137	regulation of response to DNA damage stimulus
C3Y93_01985	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C3Y93_01990	COG1011	Hydrolase
C3Y93_02020	COG1218	3'(2'),5'-bisphosphate nucleotidase
C3Y93_02035	COG0268	Binds directly to 16S ribosomal RNA
C3Y93_02040	COG0702	epimerase
C3Y93_02045	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C3Y93_02060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C3Y93_02100	COG0316	Belongs to the HesB IscA family
C3Y93_02105	COG0822	iron-sulfur transferase activity
C3Y93_02135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3Y93_02160	COG0537	adenosine 5'-monophosphoramidase activity
C3Y93_02190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C3Y93_02210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3Y93_02220	COG0133	tryptophan synthase activity
C3Y93_02225	COG0517	IMP dehydrogenase activity
C3Y93_02255	COG0612	Peptidase, M16
C3Y93_02260	COG0552	protein localization to endoplasmic reticulum
C3Y93_02310	COG1283	sodium-dependent phosphate transmembrane transporter activity
C3Y93_02315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C3Y93_02335	COG0596	Alpha beta hydrolase
C3Y93_02345	COG0511	ligase activity, forming carbon-carbon bonds
C3Y93_02350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C3Y93_02355	COG0642	Histidine kinase
C3Y93_02370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3Y93_02385	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C3Y93_02390	COG1944	ATP diphosphatase activity
C3Y93_02405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3Y93_02420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C3Y93_02440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3Y93_02445	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C3Y93_02450	COG0022	dehydrogenase e1 component
C3Y93_02455	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3Y93_02460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3Y93_02470	COG1063	alcohol dehydrogenase
C3Y93_02475	COG4628	conserved protein (DUF2132)
C3Y93_02490	COG1132	(ABC) transporter
C3Y93_02500	COG0509	glycine decarboxylation via glycine cleavage system
C3Y93_02505	COG2814	Major facilitator Superfamily
C3Y93_02510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C3Y93_02515	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C3Y93_02520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3Y93_02555	COG1960	acyl-CoA dehydrogenase activity
C3Y93_02585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C3Y93_02590	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C3Y93_02630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3Y93_02640	COG2814	Major facilitator Superfamily
C3Y93_02645	COG0583	DNA-binding transcription factor activity
C3Y93_02650	COG4948	Mandelate Racemase Muconate Lactonizing
C3Y93_02655	COG4829	muconolactone delta-isomerase
C3Y93_02665	COG4638	Rieske (2fe-2S)
C3Y93_02670	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C3Y93_02675	COG0543	2 iron, 2 sulfur cluster binding
C3Y93_02675	COG0633	Ferredoxin
C3Y93_02680	COG1028	Short-chain dehydrogenase reductase Sdr
C3Y93_02685	COG3135	benzoate transporter
C3Y93_02690	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C3Y93_02695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C3Y93_02700	COG0183	Belongs to the thiolase family
C3Y93_02705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C3Y93_02710	COG0183	Belongs to the thiolase family
C3Y93_02720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C3Y93_02725	COG2937	Belongs to the GPAT DAPAT family
C3Y93_02730	COG0640	Transcriptional regulator
C3Y93_02745	COG3619	membrane
C3Y93_02750	COG3122	Protein conserved in bacteria
C3Y93_02755	COG0668	transmembrane transport
C3Y93_02765	COG3706	GGDEF domain
C3Y93_02775	COG2814	Major facilitator Superfamily
C3Y93_02795	COG3179	chitinase
C3Y93_02890	COG4387	Mu-like prophage protein GP36
C3Y93_02935	COG5410	chromosome segregation
C3Y93_03025	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C3Y93_03140	COG1058	Belongs to the CinA family
C3Y93_03140	COG1546	Belongs to the CinA family
C3Y93_03155	COG0372	Belongs to the citrate synthase family
C3Y93_03185	COG0542	response to heat
C3Y93_03190	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C3Y93_03210	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C3Y93_03220	COG0569	domain protein
C3Y93_03225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3Y93_03245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3Y93_03255	COG1585	Membrane protein implicated in regulation of membrane protease activity
C3Y93_03270	COG1294	oxidase, subunit
C3Y93_03275	COG4890	Cyd operon protein YbgT
C3Y93_03310	COG1960	acyl-CoA dehydrogenase activity
C3Y93_03315	COG1960	acyl-CoA dehydrogenase activity
C3Y93_03330	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3Y93_03335	COG2207	Transcriptional regulator
C3Y93_03340	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3Y93_03345	COG0730	response to heat
C3Y93_03350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C3Y93_03375	COG0772	Belongs to the SEDS family
C3Y93_03385	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C3Y93_03390	COG0148	phosphopyruvate hydratase activity
C3Y93_03420	COG1902	pentaerythritol trinitrate reductase activity
C3Y93_03420	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3Y93_03430	COG2267	carboxylic ester hydrolase activity
C3Y93_03435	COG1960	acyl-CoA dehydrogenase activity
C3Y93_03440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C3Y93_03445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C3Y93_03470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3Y93_03480	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3Y93_03490	COG0778	Nitroreductase
C3Y93_03515	COG0126	phosphoglycerate kinase activity
C3Y93_03525	COG0424	maF-like protein
C3Y93_03530	COG2850	peptidyl-arginine hydroxylation
C3Y93_03535	COG4585	Histidine kinase
C3Y93_03540	COG2197	response regulator
C3Y93_03560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3Y93_03565	COG1454	alcohol dehydrogenase
C3Y93_03570	COG0824	Thioesterase
C3Y93_03575	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C3Y93_03595	COG0183	Belongs to the thiolase family
C3Y93_03610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3Y93_03620	COG3135	benzoate transporter
C3Y93_03630	COG0589	response to stress
C3Y93_03635	COG0589	response to stress
C3Y93_03645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3Y93_03650	COG0308	aminopeptidase N
C3Y93_03685	COG0729	surface antigen
C3Y93_03690	COG0477	Major facilitator Superfamily
C3Y93_03705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C3Y93_03715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C3Y93_03725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3Y93_03730	COG1960	acyl-CoA dehydrogenase activity
C3Y93_03750	COG3781	membrane
C3Y93_03755	COG2890	protein-(glutamine-N5) methyltransferase activity
C3Y93_03760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C3Y93_03775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3Y93_03800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C3Y93_03805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3Y93_03810	COG1845	cytochrome c oxidase, subunit III
C3Y93_03815	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C3Y93_03825	COG0360	Binds together with S18 to 16S ribosomal RNA
C3Y93_03830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C3Y93_03840	COG0305	Participates in initiation and elongation during chromosome replication
C3Y93_03850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C3Y93_03865	COG3243	poly(R)-hydroxyalkanoic acid synthase
C3Y93_03870	COG0183	Belongs to the thiolase family
C3Y93_03915	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C3Y93_03920	COG0138	bifunctional purine biosynthesis protein purh
C3Y93_03930	COG1464	Belongs to the NlpA lipoprotein family
C3Y93_03935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C3Y93_03940	COG2011	ABC-type metal ion transport system permease component
C3Y93_04050	COG3311	Transcriptional regulator
C3Y93_04060	COG4372	Transposase
C3Y93_04070	COG2963	transposase activity
C3Y93_04105	COG0582	viral genome integration into host DNA
C3Y93_04115	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C3Y93_04125	COG4122	O-methyltransferase activity
C3Y93_04145	COG1137	ATPase activity
C3Y93_04150	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C3Y93_04160	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C3Y93_04165	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C3Y93_04165	COG0517	IMP dehydrogenase activity
C3Y93_04185	COG1643	Atp-dependent helicase
C3Y93_04190	COG0450	alkyl hydroperoxide reductase
C3Y93_04245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C3Y93_04245	COG1017	nitric oxide dioxygenase activity
C3Y93_04275	COG0352	thiamine-phosphate diphosphorylase activity
C3Y93_04315	COG0612	Peptidase, M16
C3Y93_04335	COG1686	Belongs to the peptidase S11 family
C3Y93_04340	COG1047	Peptidyl-prolyl cis-trans
C3Y93_04345	COG0415	Belongs to the DNA photolyase family
C3Y93_04360	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C3Y93_04365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3Y93_04380	COG1960	acyl-CoA dehydrogenase activity
C3Y93_04390	COG3139	Protein of unknown function (DUF1315)
C3Y93_04395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C3Y93_04400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3Y93_04410	COG0352	thiamine-phosphate diphosphorylase activity
C3Y93_04420	COG0642	Histidine kinase
C3Y93_04425	COG0745	RESPONSE REGULATOR receiver
C3Y93_04435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C3Y93_04445	COG1720	tRNA m6t6A37 methyltransferase activity
C3Y93_04470	COG0789	Transcriptional regulator
C3Y93_04475	COG0431	NADPH-dependent FMN reductase
C3Y93_04480	COG0798	PFAM Bile acid sodium symporter
C3Y93_04485	COG0640	Transcriptional regulator
C3Y93_04500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C3Y93_04505	COG3634	alkyl hydroperoxide reductase activity
C3Y93_04525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3Y93_04565	COG3177	Filamentation induced by cAMP protein fic
C3Y93_04685	COG2433	Pfam Transposase IS66
C3Y93_04690	COG2963	transposase activity
C3Y93_04700	COG0582	viral genome integration into host DNA
C3Y93_04705	COG0582	viral genome integration into host DNA
C3Y93_04720	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C3Y93_04720	COG2755	lipolytic protein G-D-S-L family
C3Y93_04855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C3Y93_04870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C3Y93_04905	COG0582	viral genome integration into host DNA
C3Y93_04915	COG1131	(ABC) transporter
C3Y93_04920	COG0842	Transport permease protein
C3Y93_04935	COG2951	lytic endotransglycosylase activity
C3Y93_04960	COG0052	Belongs to the universal ribosomal protein uS2 family
C3Y93_04965	COG0024	Methionine aminopeptidase
C3Y93_04985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3Y93_04990	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3Y93_05005	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C3Y93_05030	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C3Y93_05035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C3Y93_05040	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C3Y93_05050	COG0281	malic enzyme
C3Y93_05050	COG0280	phosphate acetyltransferase
C3Y93_05060	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C3Y93_05070	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3Y93_05070	COG0047	phosphoribosylformylglycinamidine synthase activity
C3Y93_05075	COG2885	chlorophyll binding
C3Y93_05120	COG1902	pentaerythritol trinitrate reductase activity
C3Y93_05120	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3Y93_05130	COG0675	Transposase, IS605 OrfB family
C3Y93_05140	COG2203	Gaf domain
C3Y93_05140	COG3706	GGDEF domain
C3Y93_05140	COG4251	negative regulation of phosphorylation
C3Y93_05140	COG5001	Diguanylate cyclase
C3Y93_05145	COG0418	dihydroorotase activity
C3Y93_05150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C3Y93_05160	COG0833	amino acid
C3Y93_05185	COG4172	Belongs to the ABC transporter superfamily
C3Y93_05190	COG4239	(ABC) transporter, permease
C3Y93_05195	COG4174	ABC transporter (Permease)
C3Y93_05200	COG4166	transmembrane transport
C3Y93_05205	COG0741	lytic transglycosylase activity
C3Y93_05205	COG0741	lytic transglycosylase activity
C3Y93_05205	COG1388	LysM domain
C3Y93_05205	COG1388	LysM domain
C3Y93_05210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C3Y93_05220	COG2816	NAD+ diphosphatase activity
C3Y93_05250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C3Y93_05255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C3Y93_05260	COG3077	Addiction module antitoxin, RelB DinJ family
C3Y93_05270	COG0006	proline dipeptidase activity
C3Y93_05275	COG3079	Belongs to the UPF0149 family
C3Y93_05300	COG4680	protein conserved in bacteria
C3Y93_05305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C3Y93_05310	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C3Y93_05330	COG0789	Transcriptional regulator
C3Y93_05345	COG2194	sulfuric ester hydrolase activity
C3Y93_05350	COG0745	RESPONSE REGULATOR receiver
C3Y93_05355	COG0642	Histidine kinase
C3Y93_05375	COG3706	GGDEF domain
C3Y93_05375	COG0745	RESPONSE REGULATOR receiver
C3Y93_05390	COG0277	FAD linked oxidase domain protein
C3Y93_05400	COG2186	Transcriptional regulator
C3Y93_05420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C3Y93_05430	COG2234	aminopeptidase activity
C3Y93_05450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C3Y93_05455	COG2878	Part of a membrane complex involved in electron transport
C3Y93_05460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C3Y93_05485	COG0768	penicillin binding
C3Y93_05490	COG0742	ribosomal rna small subunit methyltransferase
C3Y93_05500	COG0204	Acyl-transferase
C3Y93_05520	COG1253	flavin adenine dinucleotide binding
C3Y93_05540	COG3118	belongs to the thioredoxin family
C3Y93_05545	COG2199	diguanylate cyclase activity
C3Y93_05545	COG2203	Gaf domain
C3Y93_05555	COG4681	YaeQ
C3Y93_05560	COG0523	cobalamin synthesis protein
C3Y93_05570	COG1607	acyl-coa hydrolase
C3Y93_05575	COG1752	Esterase of the alpha-beta hydrolase superfamily
C3Y93_05580	COG2059	Chromate
C3Y93_05585	COG0786	glutamate:sodium symporter activity
C3Y93_05595	COG2814	Major facilitator Superfamily
C3Y93_05600	COG1289	transmembrane transporter activity
C3Y93_05670	COG2832	Protein of unknown function (DUF454)
C3Y93_05680	COG5510	response to toxic substance
C3Y93_05685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3Y93_05695	COG2198	Histidine kinase
C3Y93_05695	COG0643	Histidine kinase
C3Y93_05695	COG2198	Histidine kinase
C3Y93_05695	COG0643	Histidine kinase
C3Y93_05700	COG0840	transmembrane signaling receptor activity
C3Y93_05725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3Y93_05770	COG0489	protein tyrosine kinase activity
C3Y93_05775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3Y93_05775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3Y93_05800	COG4716	Myosin-crossreactive antigen
C3Y93_05810	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C3Y93_05815	COG2081	HI0933 family
C3Y93_05820	COG0668	transmembrane transport
C3Y93_05845	COG0583	DNA-binding transcription factor activity
C3Y93_05850	COG1278	Cold shock
C3Y93_05855	COG1278	Cold shock
C3Y93_05870	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3Y93_05875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3Y93_05880	COG0713	ATP synthesis coupled electron transport
C3Y93_05890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3Y93_05905	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C3Y93_05915	COG0649	NAD binding
C3Y93_05915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3Y93_05925	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3Y93_05935	COG0142	geranyltranstransferase activity
C3Y93_05940	COG2828	Protein conserved in bacteria
C3Y93_05945	COG1113	amino acid transport
C3Y93_05950	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C3Y93_05955	COG1840	ABC-type Fe3 transport system, periplasmic component
C3Y93_05975	COG0560	Phosphoserine phosphatase
C3Y93_05985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3Y93_05990	COG1530	ribonuclease E activity
C3Y93_05995	COG0424	maF-like protein
C3Y93_06000	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C3Y93_06005	COG1792	Involved in formation and maintenance of cell shape
C3Y93_06010	COG1077	Cell shape determining protein MreB Mrl
C3Y93_06015	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3Y93_06025	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3Y93_06045	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C3Y93_06060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C3Y93_06085	COG0577	efflux transmembrane transporter activity
C3Y93_06085	COG1136	(ABC) transporter
C3Y93_06095	COG4185	zeta toxin
C3Y93_06105	COG0730	response to heat
C3Y93_06115	COG3604	Transcriptional regulator
C3Y93_06120	COG0300	oxidoreductase activity
C3Y93_06130	COG1022	Amp-dependent synthetase and ligase
C3Y93_06140	COG2050	protein possibly involved in aromatic compounds catabolism
C3Y93_06150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3Y93_06155	COG1090	epimerase
C3Y93_06165	COG0420	3'-5' exonuclease activity
C3Y93_06195	COG0735	belongs to the Fur family
C3Y93_06200	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C3Y93_06205	COG2914	Belongs to the UPF0125 (RnfH) family
C3Y93_06220	COG0121	glutamine amidotransferase
C3Y93_06230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C3Y93_06235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3Y93_06240	COG0756	dUTP diphosphatase activity
C3Y93_06245	COG0210	DNA helicase
C3Y93_06250	COG2885	chlorophyll binding
C3Y93_06255	COG0204	Acyl-transferase
C3Y93_06270	COG2894	cell division
C3Y93_06285	COG1674	ftsk spoiiie
C3Y93_06285	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C3Y93_06290	COG0492	ferredoxin-NADP+ reductase activity
C3Y93_06295	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C3Y93_06305	COG0456	acetyltransferase
C3Y93_06360	COG0351	phosphomethylpyrimidine kinase
C3Y93_06360	COG0352	thiamine-phosphate diphosphorylase activity
C3Y93_06370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3Y93_06375	COG2076	Multidrug Resistance protein
C3Y93_06390	COG2132	Multicopper oxidase
C3Y93_06400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C3Y93_06415	COG4269	membrane
C3Y93_06435	COG1968	undecaprenyl-diphosphatase activity
C3Y93_06440	COG1214	PFAM Peptidase M22, glycoprotease
C3Y93_06450	COG0494	nUDIX hydrolase
C3Y93_06500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C3Y93_06505	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C3Y93_06575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3Y93_06580	COG1764	response to oxidative stress
C3Y93_06625	COG0037	tRNA processing
C3Y93_06635	COG0248	Ppx GppA phosphatase
C3Y93_06660	COG0072	phenylalanine-tRNA ligase activity
C3Y93_06665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C3Y93_06675	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C3Y93_06690	COG1238	metal cluster binding
C3Y93_06700	COG0625	glutathione transferase activity
C3Y93_06705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C3Y93_06735	COG0318	PFAM AMP-dependent synthetase and ligase
C3Y93_06740	COG3028	Belongs to the UPF0307 family
C3Y93_06750	COG1660	Displays ATPase and GTPase activities
C3Y93_06765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C3Y93_06770	COG0617	tRNA 3'-terminal CCA addition
C3Y93_06775	COG1555	photosystem II stabilization
C3Y93_06775	COG1596	polysaccharide export
C3Y93_06780	COG3956	TIGRFAM MazG family protein
C3Y93_06795	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C3Y93_06815	COG1426	Protein conserved in bacteria
C3Y93_06835	COG2975	iron-sulfur cluster assembly
C3Y93_06875	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C3Y93_06895	COG0133	tryptophan synthase activity
C3Y93_06905	COG4206	TonB-dependent receptor
C3Y93_06910	COG2096	Adenosyltransferase
C3Y93_06930	COG2315	Protein conserved in bacteria
C3Y93_06945	COG0745	RESPONSE REGULATOR receiver
C3Y93_06950	COG2205	protein histidine kinase activity
C3Y93_06960	COG1960	acyl-CoA dehydrogenase activity
C3Y93_06965	COG1960	acyl-CoA dehydrogenase activity
C3Y93_06985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3Y93_07000	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C3Y93_07055	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C3Y93_07080	COG0726	polysaccharide deacetylase
C3Y93_07110	COG0028	Belongs to the TPP enzyme family
C3Y93_07140	COG2703	oxygen carrier activity
C3Y93_07145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3Y93_07150	COG0577	efflux transmembrane transporter activity
C3Y93_07150	COG1136	(ABC) transporter
C3Y93_07155	COG1538	Outer membrane efflux protein
C3Y93_07160	COG0784	Response regulator, receiver
C3Y93_07160	COG5002	protein histidine kinase activity
C3Y93_07160	COG2205	protein histidine kinase activity
C3Y93_07180	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C3Y93_07190	COG1704	LemA family
C3Y93_07195	COG4251	negative regulation of phosphorylation
C3Y93_07195	COG3706	GGDEF domain
C3Y93_07195	COG2203	Gaf domain
C3Y93_07195	COG5001	Diguanylate cyclase
C3Y93_07210	COG1862	Preprotein translocase
C3Y93_07230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3Y93_07250	COG5002	protein histidine kinase activity
C3Y93_07250	COG2205	protein histidine kinase activity
C3Y93_07250	COG0784	Response regulator, receiver
C3Y93_07255	COG1024	Enoyl-CoA hydratase
C3Y93_07260	COG2084	Dehydrogenase
C3Y93_07265	COG3622	Belongs to the hyi family
C3Y93_07275	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C3Y93_07280	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C3Y93_07285	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C3Y93_07300	COG2814	Major facilitator Superfamily
C3Y93_07310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C3Y93_07315	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C3Y93_07320	COG0084	hydrolase, TatD family'
C3Y93_07335	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C3Y93_07380	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C3Y93_07385	COG0857	belongs to the CobB CobQ family
C3Y93_07385	COG0280	phosphate acetyltransferase
C3Y93_07435	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C3Y93_07435	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C3Y93_07450	COG0740	serine-type endopeptidase activity
C3Y93_07460	COG4771	TonB-dependent receptor
C3Y93_07465	COG4774	siderophore transport
C3Y93_07470	COG3128	pkhd-type hydroxylase
C3Y93_07480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3Y93_07485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C3Y93_07490	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C3Y93_07490	COG2813	Specifically methylates the guanine in position
C3Y93_07545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C3Y93_07570	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3Y93_07600	COG0557	exoribonuclease II activity
C3Y93_07605	COG0339	signal peptide processing
C3Y93_07610	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C3Y93_07645	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C3Y93_07650	COG1960	acyl-CoA dehydrogenase activity
C3Y93_07655	COG2072	flavoprotein involved in K transport
C3Y93_07660	COG0203	ribosomal protein L17
C3Y93_07670	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C3Y93_07675	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C3Y93_07680	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C3Y93_07685	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3Y93_07705	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C3Y93_07715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C3Y93_07720	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C3Y93_07730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C3Y93_07770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C3Y93_07785	COG0088	Forms part of the polypeptide exit tunnel
C3Y93_07810	COG0433	COG0433 Predicted ATPase
C3Y93_07815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C3Y93_07815	COG1017	nitric oxide dioxygenase activity
C3Y93_07820	COG1959	2 iron, 2 sulfur cluster binding
C3Y93_07835	COG1301	dicarboxylic acid transport
C3Y93_07840	COG1946	Acyl-CoA thioesterase
C3Y93_07845	COG2937	Belongs to the GPAT DAPAT family
C3Y93_07855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C3Y93_07860	COG1040	competence protein
C3Y93_07875	COG0598	Magnesium transport protein CorA
C3Y93_07885	COG2854	intermembrane phospholipid transfer
C3Y93_07890	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C3Y93_07895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C3Y93_07900	COG1127	ABC transporter
C3Y93_07905	COG0513	Belongs to the DEAD box helicase family
C3Y93_07925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3Y93_07950	COG1960	acyl-CoA dehydrogenase activity
C3Y93_07955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3Y93_07965	COG0534	Mate efflux family protein
C3Y93_07970	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C3Y93_07985	COG0254	rRNA binding
C3Y93_07990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3Y93_08020	COG1192	Involved in chromosome partitioning
C3Y93_08025	COG0628	permease
C3Y93_08030	COG2032	superoxide dismutase activity
C3Y93_08035	COG2814	Major facilitator Superfamily
C3Y93_08050	COG0277	FAD linked oxidase domain protein
C3Y93_08055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C3Y93_08070	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C3Y93_08075	COG5380	lipid catabolic process
C3Y93_08080	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C3Y93_08090	COG0335	large ribosomal subunit rRNA binding
C3Y93_08100	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C3Y93_08105	COG0228	four-way junction DNA binding
C3Y93_08150	COG0194	GDP metabolic process
C3Y93_08155	COG1758	RNA polymerase activity
C3Y93_08160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3Y93_08170	COG2906	2 iron, 2 sulfur cluster binding
C3Y93_08185	COG3609	addiction module antidote protein, CC2985 family
C3Y93_08190	COG3307	-O-antigen
C3Y93_08220	COG4969	Belongs to the N-Me-Phe pilin family
C3Y93_08230	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C3Y93_08235	COG1704	LemA family
C3Y93_08240	COG0493	'glutamate synthase
C3Y93_08245	COG0067	glutamate synthase
C3Y93_08245	COG0070	glutamate synthase
C3Y93_08245	COG0069	glutamate synthase activity
C3Y93_08300	COG2226	methyltransferase
C3Y93_08305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3Y93_08310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C3Y93_08315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C3Y93_08330	COG0275	rRNA processing
C3Y93_08335	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C3Y93_08345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3Y93_08365	COG0488	(ABC) transporter
C3Y93_08375	COG4221	oxidoreductase activity
C3Y93_08395	COG0745	RESPONSE REGULATOR receiver
C3Y93_08400	COG2205	protein histidine kinase activity
C3Y93_08405	COG0427	acetyl-CoA hydrolase
C3Y93_08440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C3Y93_08460	COG0697	spore germination
C3Y93_08475	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C3Y93_08500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C3Y93_08520	COG3158	transport of potassium into the cell
C3Y93_08550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3Y93_08555	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C3Y93_08560	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C3Y93_08570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3Y93_08580	COG3655	Transcriptional regulator
C3Y93_08590	COG0582	viral genome integration into host DNA
C3Y93_08670	COG4638	Rieske (2fe-2S)
C3Y93_08675	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C3Y93_08680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C3Y93_08680	COG0543	2 iron, 2 sulfur cluster binding
C3Y93_08705	COG2814	Major facilitator Superfamily
C3Y93_08710	COG1234	tRNA 3'-trailer cleavage
C3Y93_08720	COG2149	membrane
C3Y93_08735	COG2826	transposase and inactivated derivatives, IS30 family
C3Y93_08780	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3Y93_08785	COG3657	addiction module killer protein
C3Y93_08800	COG0583	DNA-binding transcription factor activity
C3Y93_08805	COG2814	Major facilitator Superfamily
C3Y93_08825	COG1012	belongs to the aldehyde dehydrogenase family
C3Y93_08840	COG3316	Transposase and inactivated derivatives
C3Y93_08845	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C3Y93_08875	COG3316	Transposase and inactivated derivatives
C3Y93_08905	COG3316	Transposase and inactivated derivatives
C3Y93_08925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3Y93_08975	COG3316	Transposase and inactivated derivatives
C3Y93_09005	COG2862	Uncharacterized protein family, UPF0114
C3Y93_09020	COG3316	Transposase and inactivated derivatives
C3Y93_09045	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C3Y93_09065	COG3077	Addiction module antitoxin, RelB DinJ family
C3Y93_09080	COG2132	Multicopper oxidase
C3Y93_09090	COG3316	Transposase and inactivated derivatives
C3Y93_09110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3Y93_09115	COG0668	transmembrane transport
C3Y93_09125	COG1519	Transferase
C3Y93_09130	COG1902	pentaerythritol trinitrate reductase activity
C3Y93_09150	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C3Y93_09175	COG0426	domain, Protein
C3Y93_09175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C3Y93_09180	COG2119	membrane
C3Y93_09205	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C3Y93_09210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C3Y93_09220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C3Y93_09230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C3Y93_09240	COG0189	ligase activity
C3Y93_09265	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C3Y93_09270	COG0708	Exodeoxyribonuclease III
C3Y93_09275	COG1393	Belongs to the ArsC family
C3Y93_09290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C3Y93_09330	COG0471	metal ion transport
C3Y93_09345	COG3150	esterase
C3Y93_09360	COG2918	glutathione biosynthetic process
C3Y93_09375	COG2733	membrane
C3Y93_09400	COG2826	transposase and inactivated derivatives, IS30 family
C3Y93_09405	COG0436	Aminotransferase
C3Y93_09410	COG0534	Mate efflux family protein
C3Y93_09470	COG0560	Phosphoserine phosphatase
C3Y93_09470	COG3830	Belongs to the UPF0237 family
C3Y93_09485	COG1335	isochorismatase
C3Y93_09495	COG2814	Major facilitator Superfamily
C3Y93_09500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3Y93_09510	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C3Y93_09520	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C3Y93_09525	COG2983	Belongs to the UPF0260 family
C3Y93_09530	COG5487	UPF0391 membrane protein
C3Y93_09545	COG1194	a g-specific adenine glycosylase
C3Y93_09560	COG2818	Glycosylase
C3Y93_09565	COG1064	alcohol dehydrogenase
C3Y93_09585	COG3023	N-Acetylmuramoyl-L-alanine amidase
C3Y93_09600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C3Y93_09615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C3Y93_09620	COG0546	phosphoglycolate phosphatase activity
C3Y93_09625	COG1028	Short-chain dehydrogenase reductase Sdr
C3Y93_09645	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C3Y93_09645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C3Y93_09650	COG1309	transcriptional regulator
C3Y93_09660	COG0196	riboflavin kinase activity
C3Y93_09665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C3Y93_09670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C3Y93_09675	COG1047	Peptidyl-prolyl cis-trans
C3Y93_09680	COG2133	pyrroloquinoline quinone binding
C3Y93_09685	COG2814	Major facilitator Superfamily
C3Y93_09715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C3Y93_09720	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C3Y93_09725	COG0316	Belongs to the HesB IscA family
C3Y93_09740	COG0488	(ABC) transporter
C3Y93_09750	COG0187	DNA topoisomerase II activity
C3Y93_09760	COG0592	DNA-directed DNA polymerase activity
C3Y93_09770	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C3Y93_09775	COG0594	ribonuclease P activity
C3Y93_09780	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C3Y93_09785	COG0706	membrane insertase activity
C3Y93_09810	COG1230	cation diffusion facilitator family transporter
C3Y93_09815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C3Y93_09830	COG0402	S-adenosylhomocysteine deaminase activity
C3Y93_09835	COG0861	Integral membrane protein TerC family
C3Y93_09850	COG2200	EAL domain
C3Y93_09855	COG1063	alcohol dehydrogenase
C3Y93_09860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C3Y93_09875	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C3Y93_09880	COG2951	lytic endotransglycosylase activity
C3Y93_09900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C3Y93_09920	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3Y93_09955	COG1012	belongs to the aldehyde dehydrogenase family
C3Y93_09960	COG0733	neurotransmitter:sodium symporter activity
C3Y93_09970	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C3Y93_09980	COG0129	dihydroxy-acid dehydratase activity
C3Y93_09985	COG0129	dihydroxy-acid dehydratase activity
C3Y93_10015	COG2233	PERMEase
C3Y93_10020	COG3706	GGDEF domain
C3Y93_10020	COG0745	RESPONSE REGULATOR receiver
C3Y93_10030	COG1309	transcriptional regulator
C3Y93_10090	COG2246	polysaccharide biosynthetic process
C3Y93_10095	COG0463	Glycosyl transferase, family 2
C3Y93_10105	COG2801	Transposase and inactivated derivatives
C3Y93_10130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C3Y93_10165	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C3Y93_10175	COG1132	(ABC) transporter
C3Y93_10180	COG1086	Polysaccharide biosynthesis protein
C3Y93_10185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3Y93_10190	COG1083	cytidylyl-transferase
C3Y93_10195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3Y93_10205	COG2089	acid synthase
C3Y93_10215	COG1215	transferase activity, transferring glycosyl groups
C3Y93_10240	COG0438	transferase activity, transferring glycosyl groups
C3Y93_10245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C3Y93_10255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3Y93_10265	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C3Y93_10280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C3Y93_10305	COG4115	mRNA cleavage
C3Y93_10315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3Y93_10330	COG0271	Belongs to the BolA IbaG family
C3Y93_10335	COG3094	Invasion gene expression up-regulator, SirB
C3Y93_10340	COG1192	Involved in chromosome partitioning
C3Y93_10355	COG0586	Pfam SNARE associated Golgi protein
C3Y93_10360	COG2259	Doxx family
C3Y93_10365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3Y93_10365	COG0519	Catalyzes the synthesis of GMP from XMP
C3Y93_10370	COG0745	RESPONSE REGULATOR receiver
C3Y93_10370	COG3706	GGDEF domain
C3Y93_10405	COG0281	malic enzyme
C3Y93_10420	COG3162	membrane
C3Y93_10425	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3Y93_10440	COG3706	GGDEF domain
C3Y93_10450	COG0352	thiamine-phosphate diphosphorylase activity
C3Y93_10450	COG0351	phosphomethylpyrimidine kinase
C3Y93_10450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C3Y93_10460	COG2814	Major facilitator Superfamily
C3Y93_10465	COG0629	single-stranded DNA binding
C3Y93_10470	COG0450	alkyl hydroperoxide reductase
C3Y93_10510	COG3179	chitinase
C3Y93_10520	COG2837	iron assimilation
C3Y93_10535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3Y93_10540	COG1121	(ABC) transporter
C3Y93_10580	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C3Y93_10590	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C3Y93_10605	COG0386	Belongs to the glutathione peroxidase family
C3Y93_10610	COG0697	spore germination
C3Y93_10630	COG0758	DNA mediated transformation
C3Y93_10680	COG2814	Major facilitator Superfamily
C3Y93_10685	COG2814	Major facilitator Superfamily
C3Y93_10705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3Y93_10745	COG1253	flavin adenine dinucleotide binding
C3Y93_10755	COG2860	membrane
C3Y93_10760	COG0477	Major facilitator Superfamily
C3Y93_10770	COG0318	PFAM AMP-dependent synthetase and ligase
C3Y93_10785	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C3Y93_10800	COG0606	chelatase, subunit chli
C3Y93_10810	COG0347	Belongs to the P(II) protein family
C3Y93_10815	COG0004	ammonium transporteR
C3Y93_10825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C3Y93_10825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C3Y93_10840	COG0586	Pfam SNARE associated Golgi protein
C3Y93_10865	COG0795	lipopolysaccharide-transporting ATPase activity
C3Y93_10870	COG0795	lipopolysaccharide-transporting ATPase activity
C3Y93_10875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C3Y93_10880	COG0793	Belongs to the peptidase S41A family
C3Y93_10895	COG2197	response regulator
C3Y93_10905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C3Y93_10915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C3Y93_10920	COG4974	Belongs to the 'phage' integrase family
C3Y93_10945	COG0772	Belongs to the SEDS family
C3Y93_10955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3Y93_10960	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C3Y93_10965	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C3Y93_10970	COG0494	nUDIX hydrolase
C3Y93_10985	COG1538	Outer membrane efflux protein
C3Y93_11005	COG3275	phosphorelay sensor kinase activity
C3Y93_11015	COG0181	hydroxymethylbilane synthase activity
C3Y93_11035	COG0824	Thioesterase
C3Y93_11120	COG0081	regulation of translation
C3Y93_11135	COG0085	RNA polymerase activity
C3Y93_11170	COG2056	Na+-H+ antiporter family
C3Y93_11175	COG3047	cAMP biosynthetic process
C3Y93_11185	COG0326	Molecular chaperone. Has ATPase activity
C3Y93_11210	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C3Y93_11230	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3Y93_11230	COG1024	Enoyl-CoA hydratase
C3Y93_11250	COG0322	excinuclease ABC activity
C3Y93_11260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C3Y93_11265	COG1132	(ABC) transporter
C3Y93_11280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C3Y93_11310	COG0497	DNA recombination
C3Y93_11315	COG3123	guanosine phosphorylase activity
C3Y93_11320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3Y93_11330	COG0237	dephospho-CoA kinase activity
C3Y93_11380	COG0779	Required for maturation of 30S ribosomal subunits
C3Y93_11385	COG0195	Participates in both transcription termination and antitermination
C3Y93_11390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C3Y93_11395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C3Y93_11405	COG2212	antiporter activity
C3Y93_11415	COG0651	ATP synthesis coupled electron transport
C3Y93_11420	COG1006	Multisubunit Na H antiporter MnhC subunit
C3Y93_11425	COG2111	Na H antiporter
C3Y93_11425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3Y93_11450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C3Y93_11460	COG2226	methyltransferase
C3Y93_11480	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C3Y93_11485	COG1074	ATP-dependent DNA helicase activity
C3Y93_11490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3Y93_11530	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C3Y93_11535	COG0475	glutathione-regulated potassium exporter activity
C3Y93_11535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C3Y93_11540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C3Y93_11555	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C3Y93_11560	COG4535	Mg2 and Co2 transporter CorC
C3Y93_11595	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C3Y93_11595	COG0644	oxidoreductase
C3Y93_11605	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C3Y93_11620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3Y93_11630	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C3Y93_11640	COG0493	'glutamate synthase
C3Y93_11680	COG0751	glycine-tRNA ligase activity
C3Y93_11705	COG0517	IMP dehydrogenase activity
C3Y93_11710	COG1983	PspC domain protein
C3Y93_11735	COG0318	PFAM AMP-dependent synthetase and ligase
C3Y93_11740	COG1530	ribonuclease E activity
C3Y93_11755	COG0546	phosphoglycolate phosphatase activity
C3Y93_11760	COG3971	2-oxopent-4-enoate hydratase activity
C3Y93_11765	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C3Y93_11790	COG0583	DNA-binding transcription factor activity
C3Y93_11795	COG4638	Rieske (2fe-2S)
C3Y93_11810	COG1028	Short-chain dehydrogenase reductase Sdr
C3Y93_11815	COG3384	dioxygenase
C3Y93_11820	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3Y93_11825	COG0697	spore germination
C3Y93_11835	COG0753	catalase activity
C3Y93_11845	COG1960	acyl-CoA dehydrogenase activity
C3Y93_11885	COG0583	DNA-binding transcription factor activity
C3Y93_11895	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C3Y93_11910	COG0473	3-isopropylmalate dehydrogenase activity
C3Y93_11930	COG0101	tRNA pseudouridine synthase activity
C3Y93_11935	COG0252	asparaginase activity
C3Y93_11965	COG1560	Kdo2-lipid A biosynthetic process
C3Y93_12010	COG0724	RNA recognition motif
C3Y93_12025	COG4651	solute:proton antiporter activity
C3Y93_12025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C3Y93_12030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3Y93_12035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3Y93_12050	COG0788	formyltetrahydrofolate deformylase activity
C3Y93_12075	COG1295	ribonuclease BN
C3Y93_12120	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C3Y93_12125	COG1702	phosphate starvation-inducible protein PhoH
C3Y93_12130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3Y93_12135	COG1196	nuclear chromosome segregation
C3Y93_12135	COG0739	heme binding
C3Y93_12135	COG0741	lytic transglycosylase activity
C3Y93_12150	COG2391	methyltransferase activity
C3Y93_12175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C3Y93_12180	COG1183	phosphatidylcholine synthase activity
C3Y93_12230	COG3453	Protein conserved in bacteria
C3Y93_12230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3Y93_12245	COG1607	acyl-coa hydrolase
C3Y93_12255	COG1666	GTP binding
C3Y93_12275	COG2350	Protein conserved in bacteria
C3Y93_12290	COG3781	membrane
C3Y93_12300	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C3Y93_12310	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C3Y93_12320	COG1162	GTPase activity
C3Y93_12325	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C3Y93_12345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C3Y93_12350	COG0285	dihydrofolate synthase activity
C3Y93_12365	COG0450	alkyl hydroperoxide reductase
C3Y93_12380	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C3Y93_12385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C3Y93_12410	COG2885	chlorophyll binding
C3Y93_12415	COG3300	MHYT domain
C3Y93_12415	COG5001	Diguanylate cyclase
C3Y93_12460	COG2969	positive regulation of protein catabolic process
C3Y93_12465	COG0625	glutathione transferase activity
C3Y93_12470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C3Y93_12475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C3Y93_12490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3Y93_12495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C3Y93_12525	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C3Y93_12535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3Y93_12540	COG1408	metallophosphoesterase
C3Y93_12545	COG0477	Major facilitator Superfamily
C3Y93_12550	COG1272	protein, Hemolysin III
C3Y93_12560	COG2153	protein acetylation
C3Y93_12570	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3Y93_12570	COG1024	Enoyl-CoA hydratase
C3Y93_12575	COG0183	Belongs to the thiolase family
C3Y93_12580	COG2207	Transcriptional regulator
C3Y93_12590	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3Y93_12605	COG0183	Belongs to the thiolase family
C3Y93_12615	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C3Y93_12615	COG2885	chlorophyll binding
C3Y93_12620	COG0833	amino acid
C3Y93_12630	COG2233	PERMEase
C3Y93_12640	COG1970	mechanosensitive ion channel activity
C3Y93_12645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3Y93_12655	COG1902	pentaerythritol trinitrate reductase activity
C3Y93_12670	COG0354	folic acid binding
C3Y93_12705	COG0564	pseudouridine synthase activity
C3Y93_12720	COG3189	MarR family transcriptional regulator
C3Y93_12725	COG2824	Alkylphosphonate utilization operon protein PhnA
C3Y93_12730	COG3422	double-strand break repair
C3Y93_12735	COG5342	invasion associated locus B
C3Y93_12740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C3Y93_12750	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C3Y93_12765	COG0730	response to heat
C3Y93_12775	COG1196	nuclear chromosome segregation
C3Y93_12780	COG3115	cell septum assembly
C3Y93_12785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C3Y93_12790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3Y93_12795	COG2193	ferroxidase activity
C3Y93_12800	COG0596	Alpha beta hydrolase
C3Y93_12800	COG2226	methyltransferase
C3Y93_12800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C3Y93_12815	COG4106	trans-aconitate 2-methyltransferase activity
C3Y93_12830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C3Y93_12835	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C3Y93_12840	COG0009	L-threonylcarbamoyladenylate synthase
C3Y93_12845	COG3101	peptidyl-lysine hydroxylation
C3Y93_12850	COG1399	metal-binding, possibly nucleic acid-binding protein
C3Y93_12865	COG1028	Short-chain dehydrogenase reductase Sdr
C3Y93_12875	COG1652	LysM domain
C3Y93_12890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3Y93_12905	COG0745	RESPONSE REGULATOR receiver
C3Y93_12910	COG2205	protein histidine kinase activity
C3Y93_12915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3Y93_12930	COG1752	Esterase of the alpha-beta hydrolase superfamily
C3Y93_12945	COG2323	membrane
C3Y93_12955	COG0484	heat shock protein binding
C3Y93_12960	COG0525	valine-tRNA ligase activity
C3Y93_12970	COG1028	Short-chain dehydrogenase reductase Sdr
C3Y93_12985	COG0393	Putative heavy-metal-binding
C3Y93_12990	COG1538	Outer membrane efflux protein
C3Y93_13000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3Y93_13005	COG0671	phosphoesterase, PA-phosphatase related
C3Y93_13030	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C3Y93_13045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3Y93_13050	COG1648	precorrin-2 dehydrogenase activity
C3Y93_13050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3Y93_13055	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C3Y93_13060	COG0531	amino acid
C3Y93_13075	COG0321	lipoyl(octanoyl) transferase activity
C3Y93_13085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3Y93_13110	COG0586	Pfam SNARE associated Golgi protein
C3Y93_13145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C3Y93_13175	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C3Y93_13185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C3Y93_13190	COG0358	DNA primase activity
C3Y93_13200	COG0564	pseudouridine synthase activity
C3Y93_13225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C3Y93_13250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3Y93_13250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C3Y93_13265	COG2009	succinate dehydrogenase
C3Y93_13270	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C3Y93_13275	COG1053	succinate dehydrogenase
C3Y93_13280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C3Y93_13300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3Y93_13320	COG2354	Protein conserved in bacteria
C3Y93_13325	COG2321	neutral zinc metallopeptidase
C3Y93_13330	COG3695	enzyme binding
C3Y93_13335	COG0589	response to stress
C3Y93_13360	COG0505	Belongs to the CarA family
C3Y93_13380	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C3Y93_13385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3Y93_13390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C3Y93_13430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C3Y93_13470	COG0459	protein refolding
C3Y93_13490	COG2239	Acts as a magnesium transporter
C3Y93_13500	COG0501	Belongs to the peptidase M48B family
C3Y93_13505	COG0739	heme binding
C3Y93_13505	COG0741	lytic transglycosylase activity
C3Y93_13505	COG1196	nuclear chromosome segregation
C3Y93_13525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3Y93_13535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3Y93_13545	COG0306	phosphate transporter
C3Y93_13590	COG4181	ATPase activity
C3Y93_13595	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C3Y93_13605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3Y93_13620	COG0583	DNA-binding transcription factor activity
C3Y93_13625	COG2267	carboxylic ester hydrolase activity
C3Y93_13630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3Y93_13635	COG1773	rubredoxin
C3Y93_13640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3Y93_13655	COG3093	addiction module antidote protein HigA
C3Y93_13660	COG3549	Plasmid maintenance system killer
C3Y93_13670	COG0175	sulfate reduction
C3Y93_13740	COG2871	sodium ion transport
C3Y93_13755	COG2072	flavoprotein involved in K transport
C3Y93_13760	COG1741	Belongs to the pirin family
C3Y93_13775	COG3739	integral membrane protein
C3Y93_13790	COG3706	GGDEF domain
C3Y93_13810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C3Y93_13815	COG0512	Glutamine amidotransferase of anthranilate synthase
C3Y93_13830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C3Y93_13865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C3Y93_13870	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C3Y93_13875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3Y93_13890	COG1115	amino acid carrier protein
C3Y93_13900	COG0019	diaminopimelate decarboxylase activity
C3Y93_13915	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C3Y93_13955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3Y93_13990	COG1671	Belongs to the UPF0178 family
C3Y93_14005	COG4591	ABC-type transport system involved in lipoprotein release permease component
C3Y93_14010	COG1136	(ABC) transporter
C3Y93_14015	COG0658	competence protein
C3Y93_14015	COG2333	competence protein COMEC
C3Y93_14035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C3Y93_14040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C3Y93_14055	COG3173	Aminoglycoside phosphotransferase
C3Y93_14080	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3Y93_14085	COG3657	addiction module killer protein
C3Y93_14100	COG2826	transposase and inactivated derivatives, IS30 family
C3Y93_14195	COG1396	sequence-specific DNA binding