locus-tag	class	description
AMD27_00010	COG0592	DNA-directed DNA polymerase activity
AMD27_00020	COG0187	DNA topoisomerase II activity
AMD27_00050	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AMD27_00055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AMD27_00060	COG0488	(ABC) transporter
AMD27_00070	COG0789	Transcriptional regulator
AMD27_00080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMD27_00100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AMD27_00130	COG2814	Major facilitator Superfamily
AMD27_00135	COG1012	belongs to the aldehyde dehydrogenase family
AMD27_00140	COG3738	Protein conserved in bacteria
AMD27_00145	COG0733	neurotransmitter:sodium symporter activity
AMD27_00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AMD27_00215	COG2233	PERMEase
AMD27_00235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD27_00260	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_00265	COG0546	phosphoglycolate phosphatase activity
AMD27_00270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMD27_00285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMD27_00285	COG1017	nitric oxide dioxygenase activity
AMD27_00310	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AMD27_00330	COG3023	N-Acetylmuramoyl-L-alanine amidase
AMD27_00335	COG0728	peptidoglycan biosynthetic process
AMD27_00360	COG1596	polysaccharide export
AMD27_00385	COG2244	polysaccharide biosynthetic process
AMD27_00415	COG0110	maltose O-acetyltransferase activity
AMD27_00430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AMD27_00435	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AMD27_00450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMD27_00465	COG0271	Belongs to the BolA IbaG family
AMD27_00485	COG0586	Pfam SNARE associated Golgi protein
AMD27_00490	COG2259	Doxx family
AMD27_00495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMD27_00495	COG0519	Catalyzes the synthesis of GMP from XMP
AMD27_00500	COG1715	Restriction endonuclease
AMD27_00520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD27_00555	COG0281	malic enzyme
AMD27_00565	COG3501	Rhs element vgr protein
AMD27_00585	COG2837	iron assimilation
AMD27_00600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMD27_00605	COG1121	(ABC) transporter
AMD27_00645	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AMD27_00655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AMD27_00690	COG0386	Belongs to the glutathione peroxidase family
AMD27_00710	COG0758	DNA mediated transformation
AMD27_00715	COG1652	LysM domain
AMD27_00770	COG3293	Transposase
AMD27_00790	COG2814	Major facilitator Superfamily
AMD27_00795	COG2814	Major facilitator Superfamily
AMD27_00820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMD27_00840	COG1253	flavin adenine dinucleotide binding
AMD27_00850	COG2860	membrane
AMD27_00855	COG0477	Major facilitator Superfamily
AMD27_00865	COG0318	PFAM AMP-dependent synthetase and ligase
AMD27_00880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AMD27_00900	COG0606	chelatase, subunit chli
AMD27_00910	COG0347	Belongs to the P(II) protein family
AMD27_00915	COG0004	ammonium transporteR
AMD27_00925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMD27_00925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMD27_00940	COG0586	Pfam SNARE associated Golgi protein
AMD27_00965	COG0795	lipopolysaccharide-transporting ATPase activity
AMD27_00970	COG0795	lipopolysaccharide-transporting ATPase activity
AMD27_00975	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AMD27_00980	COG3409	Peptidoglycan-binding domain 1 protein
AMD27_00980	COG0793	Belongs to the peptidase S41A family
AMD27_00995	COG2197	response regulator
AMD27_01010	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMD27_01020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AMD27_01025	COG4974	Belongs to the 'phage' integrase family
AMD27_01050	COG0772	Belongs to the SEDS family
AMD27_01060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD27_01065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AMD27_01070	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AMD27_01080	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AMD27_01110	COG2972	Histidine kinase
AMD27_01110	COG0745	RESPONSE REGULATOR receiver
AMD27_01120	COG0181	hydroxymethylbilane synthase activity
AMD27_01170	COG0546	phosphoglycolate phosphatase activity
AMD27_01200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMD27_01210	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AMD27_01220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMD27_01225	COG0081	regulation of translation
AMD27_01230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AMD27_01235	COG0222	ribosome binding
AMD27_01240	COG0085	RNA polymerase activity
AMD27_01245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AMD27_01270	COG2056	Na+-H+ antiporter family
AMD27_01275	COG3047	cAMP biosynthetic process
AMD27_01285	COG0326	Molecular chaperone. Has ATPase activity
AMD27_01305	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMD27_01315	COG2203	Gaf domain
AMD27_01315	COG2199	diguanylate cyclase activity
AMD27_01335	COG0183	Belongs to the thiolase family
AMD27_01340	COG1024	Enoyl-CoA hydratase
AMD27_01340	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMD27_01370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMD27_01395	COG1289	transmembrane transporter activity
AMD27_01410	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AMD27_01420	COG0497	DNA recombination
AMD27_01435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMD27_01445	COG0237	dephospho-CoA kinase activity
AMD27_01500	COG0779	Required for maturation of 30S ribosomal subunits
AMD27_01505	COG0195	Participates in both transcription termination and antitermination
AMD27_01515	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AMD27_01525	COG1704	LemA family
AMD27_01530	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AMD27_01545	COG3307	-O-antigen
AMD27_01555	COG3307	-O-antigen
AMD27_01575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMD27_01580	COG1758	RNA polymerase activity
AMD27_01585	COG0194	GDP metabolic process
AMD27_01590	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMD27_01665	COG0228	four-way junction DNA binding
AMD27_01670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AMD27_01680	COG0335	large ribosomal subunit rRNA binding
AMD27_01685	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AMD27_01690	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AMD27_01695	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AMD27_01700	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AMD27_01705	COG5380	lipid catabolic process
AMD27_01710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AMD27_01725	COG5006	permease, DMT superfamily
AMD27_01730	COG5006	permease, DMT superfamily
AMD27_01735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMD27_01740	COG0277	FAD linked oxidase domain protein
AMD27_01755	COG2814	Major facilitator Superfamily
AMD27_01765	COG1289	transmembrane transporter activity
AMD27_01775	COG2032	superoxide dismutase activity
AMD27_01780	COG0628	permease
AMD27_01785	COG1192	Involved in chromosome partitioning
AMD27_01860	COG0751	glycine-tRNA ligase activity
AMD27_01885	COG1983	PspC domain protein
AMD27_01910	COG1530	ribonuclease E activity
AMD27_01915	COG0564	pseudouridine synthase activity
AMD27_01920	COG0583	DNA-binding transcription factor activity
AMD27_01940	COG0753	catalase activity
AMD27_01945	COG1960	acyl-CoA dehydrogenase activity
AMD27_01960	COG0494	nUDIX hydrolase
AMD27_01990	COG0583	DNA-binding transcription factor activity
AMD27_02000	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMD27_02015	COG0473	3-isopropylmalate dehydrogenase activity
AMD27_02030	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AMD27_02070	COG1560	Kdo2-lipid A biosynthetic process
AMD27_02085	COG0831	urea catabolic process
AMD27_02095	COG0804	urea catabolic process
AMD27_02115	COG3772	lysozyme
AMD27_02130	COG0830	nickel cation binding
AMD27_02145	COG2900	Belongs to the SlyX family
AMD27_02170	COG1929	Belongs to the glycerate kinase type-1 family
AMD27_02180	COG0210	DNA helicase
AMD27_02200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AMD27_02200	COG4651	solute:proton antiporter activity
AMD27_02205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AMD27_02210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AMD27_02225	COG0788	formyltetrahydrofolate deformylase activity
AMD27_02330	COG2813	Specifically methylates the guanine in position
AMD27_02330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD27_02335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD27_02340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMD27_02350	COG4774	siderophore transport
AMD27_02370	COG0740	serine-type endopeptidase activity
AMD27_02390	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AMD27_02390	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AMD27_02405	COG0857	belongs to the CobB CobQ family
AMD27_02405	COG0280	phosphate acetyltransferase
AMD27_02410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AMD27_02450	COG0793	Belongs to the peptidase S41A family
AMD27_02460	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AMD27_02475	COG0084	hydrolase, TatD family'
AMD27_02490	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AMD27_02495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AMD27_02505	COG1358	cellular component organization or biogenesis
AMD27_02540	COG2304	oxidoreductase activity
AMD27_02555	COG2814	Major facilitator Superfamily
AMD27_02565	COG0789	Transcriptional regulator
AMD27_02575	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AMD27_02580	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AMD27_02585	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AMD27_02595	COG3622	Belongs to the hyi family
AMD27_02600	COG2084	Dehydrogenase
AMD27_02605	COG1024	Enoyl-CoA hydratase
AMD27_02610	COG5002	protein histidine kinase activity
AMD27_02610	COG0784	Response regulator, receiver
AMD27_02610	COG2205	protein histidine kinase activity
AMD27_02630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMD27_02635	COG4221	oxidoreductase activity
AMD27_02640	COG3956	TIGRFAM MazG family protein
AMD27_02645	COG1555	photosystem II stabilization
AMD27_02650	COG0617	tRNA 3'-terminal CCA addition
AMD27_02655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AMD27_02665	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AMD27_02670	COG1660	Displays ATPase and GTPase activities
AMD27_02675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMD27_02680	COG3028	Belongs to the UPF0307 family
AMD27_02690	COG0318	PFAM AMP-dependent synthetase and ligase
AMD27_02695	COG0069	glutamate synthase activity
AMD27_02695	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AMD27_02705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMD27_02710	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AMD27_02720	COG0625	glutathione transferase activity
AMD27_02730	COG1238	metal cluster binding
AMD27_02745	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AMD27_02775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMD27_02780	COG0072	phenylalanine-tRNA ligase activity
AMD27_02785	COG0776	regulation of translation
AMD27_02815	COG0037	tRNA processing
AMD27_02830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMD27_02830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMD27_02865	COG1764	response to oxidative stress
AMD27_02870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMD27_02915	COG1960	acyl-CoA dehydrogenase activity
AMD27_02920	COG1309	transcriptional regulator
AMD27_02935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMD27_02940	COG1960	acyl-CoA dehydrogenase activity
AMD27_02980	COG2969	positive regulation of protein catabolic process
AMD27_02985	COG0625	glutathione transferase activity
AMD27_02990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AMD27_02995	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AMD27_03000	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AMD27_03005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMD27_03010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AMD27_03025	COG1346	cytolysis
AMD27_03035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AMD27_03045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD27_03050	COG1408	metallophosphoesterase
AMD27_03055	COG0477	Major facilitator Superfamily
AMD27_03060	COG1272	protein, Hemolysin III
AMD27_03070	COG2153	protein acetylation
AMD27_03090	COG3293	Transposase
AMD27_03105	COG1280	lysine exporter protein (LysE YggA)
AMD27_03115	COG1024	Enoyl-CoA hydratase
AMD27_03115	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMD27_03120	COG0183	Belongs to the thiolase family
AMD27_03135	COG2207	Transcriptional regulator
AMD27_03140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMD27_03180	COG0285	dihydrofolate synthase activity
AMD27_03195	COG0450	alkyl hydroperoxide reductase
AMD27_03210	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AMD27_03215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AMD27_03240	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AMD27_03240	COG2885	chlorophyll binding
AMD27_03245	COG2199	diguanylate cyclase activity
AMD27_03295	COG1126	abc transporter atp-binding protein
AMD27_03300	COG0765	amino acid transport
AMD27_03305	COG0765	amino acid transport
AMD27_03310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMD27_03335	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AMD27_03340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AMD27_03390	COG0494	nUDIX hydrolase
AMD27_03400	COG1214	PFAM Peptidase M22, glycoprotease
AMD27_03405	COG1968	undecaprenyl-diphosphatase activity
AMD27_03440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AMD27_03445	COG2076	Multidrug Resistance protein
AMD27_03450	COG2076	Multidrug Resistance protein
AMD27_03455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AMD27_03465	COG0351	phosphomethylpyrimidine kinase
AMD27_03465	COG0352	thiamine-phosphate diphosphorylase activity
AMD27_03475	COG1522	sequence-specific DNA binding
AMD27_03490	COG0251	oxidation-reduction process
AMD27_03495	COG1113	amino acid transport
AMD27_03520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AMD27_03530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMD27_03535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMD27_03545	COG0456	acetyltransferase
AMD27_03555	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AMD27_03560	COG0500	methyltransferase
AMD27_03565	COG0492	ferredoxin-NADP+ reductase activity
AMD27_03570	COG1674	ftsk spoiiie
AMD27_03580	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AMD27_03585	COG2894	cell division
AMD27_03590	COG0850	regulation of cytokinetic process
AMD27_03600	COG0204	Acyl-transferase
AMD27_03610	COG0210	DNA helicase
AMD27_03620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMD27_03630	COG0121	glutamine amidotransferase
AMD27_03645	COG2914	Belongs to the UPF0125 (RnfH) family
AMD27_03650	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD27_03655	COG0735	belongs to the Fur family
AMD27_03685	COG0420	3'-5' exonuclease activity
AMD27_03690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMD27_03730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD27_03740	COG2050	protein possibly involved in aromatic compounds catabolism
AMD27_03745	COG1566	PFAM secretion protein HlyD family protein
AMD27_03755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMD27_03790	COG2852	Protein conserved in bacteria
AMD27_03795	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AMD27_03815	COG3177	Filamentation induced by cAMP protein fic
AMD27_03880	COG4264	IucA IucC family
AMD27_03895	COG4264	IucA IucC family
AMD27_03900	COG4264	IucA IucC family
AMD27_03940	COG2146	nitrite reductase [NAD(P)H] activity
AMD27_03955	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_03970	COG2271	Major facilitator Superfamily
AMD27_03990	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AMD27_03995	COG1012	belongs to the aldehyde dehydrogenase family
AMD27_04000	COG0028	Belongs to the TPP enzyme family
AMD27_04020	COG4772	TonB-dependent receptor
AMD27_04055	COG3706	GGDEF domain
AMD27_04060	COG0242	peptide deformylase activity
AMD27_04065	COG2066	Belongs to the glutaminase family
AMD27_04090	COG0306	phosphate transporter
AMD27_04110	COG4771	TonB-dependent receptor
AMD27_04135	COG4181	ATPase activity
AMD27_04140	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AMD27_04160	COG0583	DNA-binding transcription factor activity
AMD27_04170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMD27_04175	COG1773	rubredoxin
AMD27_04180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMD27_04185	COG3150	esterase
AMD27_04200	COG0175	sulfate reduction
AMD27_04215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AMD27_04245	COG0525	valine-tRNA ligase activity
AMD27_04255	COG4221	oxidoreductase activity
AMD27_04270	COG0393	Putative heavy-metal-binding
AMD27_04275	COG0393	Putative heavy-metal-binding
AMD27_04280	COG1538	Outer membrane efflux protein
AMD27_04285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD27_04290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD27_04310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AMD27_04320	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AMD27_04330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AMD27_04335	COG1648	precorrin-2 dehydrogenase activity
AMD27_04335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMD27_04340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AMD27_04350	COG0531	amino acid
AMD27_04365	COG0321	lipoyl(octanoyl) transferase activity
AMD27_04440	COG0586	Pfam SNARE associated Golgi protein
AMD27_04475	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AMD27_04505	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AMD27_04520	COG0358	DNA primase activity
AMD27_04565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMD27_04600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMD27_04600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AMD27_04615	COG0300	oxidoreductase activity
AMD27_04620	COG2072	flavoprotein involved in K transport
AMD27_04630	COG3104	oligopeptide transport
AMD27_04640	COG2009	succinate dehydrogenase
AMD27_04645	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AMD27_04650	COG1053	succinate dehydrogenase
AMD27_04655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AMD27_04670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMD27_04680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AMD27_04700	COG0742	ribosomal rna small subunit methyltransferase
AMD27_04705	COG0768	penicillin binding
AMD27_04725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AMD27_04730	COG2878	Part of a membrane complex involved in electron transport
AMD27_04735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AMD27_04745	COG3384	dioxygenase
AMD27_04770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AMD27_04780	COG2217	Heavy metal translocating P-type atpase
AMD27_04805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AMD27_04810	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_04840	COG0006	proline dipeptidase activity
AMD27_04875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD27_04880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMD27_04900	COG0792	nuclease activity
AMD27_04925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMD27_04930	COG0741	lytic transglycosylase activity
AMD27_04930	COG1388	LysM domain
AMD27_04930	COG0741	lytic transglycosylase activity
AMD27_04930	COG1388	LysM domain
AMD27_04940	COG4174	ABC transporter (Permease)
AMD27_04945	COG4239	(ABC) transporter, permease
AMD27_04950	COG4172	Belongs to the ABC transporter superfamily
AMD27_04960	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
AMD27_04985	COG0833	amino acid
AMD27_04995	COG1671	Belongs to the UPF0178 family
AMD27_05015	COG4591	ABC-type transport system involved in lipoprotein release permease component
AMD27_05020	COG1136	(ABC) transporter
AMD27_05025	COG3293	Transposase
AMD27_05070	COG0658	competence protein
AMD27_05070	COG2333	competence protein COMEC
AMD27_05090	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AMD27_05095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AMD27_05100	COG0628	permease
AMD27_05140	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_05140	COG0604	alcohol dehydrogenase
AMD27_05140	COG3321	synthase
AMD27_05145	COG3634	alkyl hydroperoxide reductase activity
AMD27_05155	COG0583	DNA-binding transcription factor activity
AMD27_05165	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMD27_05185	COG0789	Transcriptional regulator
AMD27_05205	COG1720	tRNA m6t6A37 methyltransferase activity
AMD27_05210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMD27_05220	COG0745	RESPONSE REGULATOR receiver
AMD27_05245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMD27_05250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMD27_05255	COG3139	Protein of unknown function (DUF1315)
AMD27_05260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AMD27_05265	COG1960	acyl-CoA dehydrogenase activity
AMD27_05280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AMD27_05320	COG0415	Belongs to the DNA photolyase family
AMD27_05330	COG1252	NADH dehydrogenase
AMD27_05335	COG1686	Belongs to the peptidase S11 family
AMD27_05385	COG0612	Peptidase, M16
AMD27_05405	COG1132	(ABC) transporter
AMD27_05415	COG1309	transcriptional regulator
AMD27_05470	COG3657	addiction module killer protein
AMD27_05475	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AMD27_05480	COG1335	isochorismatase
AMD27_05485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMD27_05495	COG0352	thiamine-phosphate diphosphorylase activity
AMD27_05520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMD27_05525	COG0697	spore germination
AMD27_05535	COG1022	Amp-dependent synthetase and ligase
AMD27_05565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AMD27_05570	COG0076	glutamate decarboxylase activity
AMD27_05580	COG0573	inorganic phosphate transmembrane transporter activity
AMD27_05590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMD27_05600	COG2814	Major facilitator Superfamily
AMD27_05635	COG1960	acyl-CoA dehydrogenase activity
AMD27_05660	COG3829	transcription factor binding
AMD27_05670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMD27_05705	COG1024	Enoyl-CoA hydratase
AMD27_05710	COG0318	PFAM AMP-dependent synthetase and ligase
AMD27_05715	COG1024	Enoyl-CoA hydratase
AMD27_05720	COG1024	Enoyl-CoA hydratase
AMD27_05720	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMD27_05725	COG0047	phosphoribosylformylglycinamidine synthase activity
AMD27_05725	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMD27_05735	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AMD27_05735	COG3323	Protein of unknown function (DUF1653)
AMD27_05740	COG0778	Nitroreductase
AMD27_05750	COG1056	cytidyltransferase-related domain
AMD27_05750	COG1051	belongs to the nudix hydrolase family
AMD27_05755	COG0583	DNA-binding transcription factor activity
AMD27_05765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AMD27_05775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AMD27_05780	COG0602	queuosine metabolic process
AMD27_05785	COG2171	N-acyltransferase activity
AMD27_05795	COG0583	DNA-binding transcription factor activity
AMD27_05800	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AMD27_05805	COG4208	sulfate ABC transporter
AMD27_05810	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AMD27_05820	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AMD27_05830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AMD27_05835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AMD27_05850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMD27_05875	COG1027	Aspartate ammonia-lyase
AMD27_05880	COG0583	DNA-binding transcription factor activity
AMD27_05885	COG1301	dicarboxylic acid transport
AMD27_05910	COG0571	ribonuclease III activity
AMD27_05915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AMD27_05925	COG1381	Involved in DNA repair and RecF pathway recombination
AMD27_05930	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AMD27_05980	COG3293	Transposase
AMD27_06005	COG1301	dicarboxylic acid transport
AMD27_06010	COG2391	methyltransferase activity
AMD27_06025	COG3634	alkyl hydroperoxide reductase activity
AMD27_06050	COG0450	alkyl hydroperoxide reductase
AMD27_06055	COG1643	Atp-dependent helicase
AMD27_06095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AMD27_06095	COG0517	IMP dehydrogenase activity
AMD27_06100	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AMD27_06110	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AMD27_06115	COG1137	ATPase activity
AMD27_06125	COG1132	(ABC) transporter
AMD27_06170	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AMD27_06190	COG0583	DNA-binding transcription factor activity
AMD27_06200	COG1280	lysine exporter protein (LysE YggA)
AMD27_06215	COG1280	lysine exporter protein (LysE YggA)
AMD27_06295	COG3311	Transcriptional regulator
AMD27_06330	COG0210	DNA helicase
AMD27_06340	COG1570	exodeoxyribonuclease VII activity
AMD27_06355	COG3501	Rhs element vgr protein
AMD27_06385	COG1968	undecaprenyl-diphosphatase activity
AMD27_06390	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AMD27_06395	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AMD27_06405	COG2205	protein histidine kinase activity
AMD27_06460	COG0436	Aminotransferase
AMD27_06465	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMD27_06470	COG0386	Belongs to the glutathione peroxidase family
AMD27_06475	COG2431	L-lysine efflux transmembrane transporter activity
AMD27_06490	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AMD27_06495	COG3293	Transposase
AMD27_06515	COG0556	nucleotide-excision repair
AMD27_06520	COG3040	lipid binding
AMD27_06555	COG0702	epimerase
AMD27_06560	COG1733	regulation of RNA biosynthetic process
AMD27_06575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AMD27_06600	COG0305	Participates in initiation and elongation during chromosome replication
AMD27_06615	COG0360	Binds together with S18 to 16S ribosomal RNA
AMD27_06625	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AMD27_06630	COG1845	cytochrome c oxidase, subunit III
AMD27_06635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMD27_06695	COG2308	Evidence 4 Homologs of previously reported genes of
AMD27_06705	COG1305	Transglutaminase-like
AMD27_06720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMD27_06725	COG3293	Transposase
AMD27_06730	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AMD27_06895	COG5410	chromosome segregation
AMD27_06900	COG3567	Phage-associated protein, HI1409 family
AMD27_06905	COG2369	cell adhesion
AMD27_07020	COG3772	lysozyme
AMD27_07065	COG0582	viral genome integration into host DNA
AMD27_07080	COG1253	flavin adenine dinucleotide binding
AMD27_07105	COG0024	Methionine aminopeptidase
AMD27_07110	COG3135	benzoate transporter
AMD27_07120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AMD27_07140	COG0183	Belongs to the thiolase family
AMD27_07175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AMD27_07180	COG0824	Thioesterase
AMD27_07185	COG1454	alcohol dehydrogenase
AMD27_07190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AMD27_07210	COG0069	glutamate synthase activity
AMD27_07215	COG2850	peptidyl-arginine hydroxylation
AMD27_07225	COG0424	maF-like protein
AMD27_07235	COG0126	phosphoglycerate kinase activity
AMD27_07245	COG0191	fructose-bisphosphate aldolase activity
AMD27_07250	COG0697	spore germination
AMD27_07275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AMD27_07280	COG0730	response to heat
AMD27_07285	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD27_07305	COG0737	Belongs to the 5'-nucleotidase family
AMD27_07335	COG2814	Major facilitator Superfamily
AMD27_07340	COG0741	lytic transglycosylase activity
AMD27_07345	COG4589	Belongs to the CDS family
AMD27_07360	COG0671	phosphoesterase, PA-phosphatase related
AMD27_07360	COG2453	phosphatase
AMD27_07365	COG2267	carboxylic ester hydrolase activity
AMD27_07370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMD27_07430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AMD27_07435	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AMD27_07450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMD27_07465	COG0517	IMP dehydrogenase activity
AMD27_07495	COG0612	Peptidase, M16
AMD27_07500	COG0552	protein localization to endoplasmic reticulum
AMD27_07525	COG4890	Cyd operon protein YbgT
AMD27_07530	COG1294	oxidase, subunit
AMD27_07545	COG1585	Membrane protein implicated in regulation of membrane protease activity
AMD27_07555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMD27_07595	COG2031	fatty acid transporter
AMD27_07600	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AMD27_07620	COG1024	Enoyl-CoA hydratase
AMD27_07625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMD27_07630	COG1960	acyl-CoA dehydrogenase activity
AMD27_07635	COG1309	transcriptional regulator
AMD27_07640	COG0318	PFAM AMP-dependent synthetase and ligase
AMD27_07650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMD27_07655	COG0318	PFAM AMP-dependent synthetase and ligase
AMD27_07665	COG0642	Histidine kinase
AMD27_07670	COG0745	RESPONSE REGULATOR receiver
AMD27_07675	COG2194	sulfuric ester hydrolase activity
AMD27_07720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMD27_07730	COG2223	nitrite transmembrane transporter activity
AMD27_07735	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AMD27_07740	COG1877	trehalose-phosphatase activity
AMD27_07745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMD27_07745	COG1116	anion transmembrane transporter activity
AMD27_07755	COG2223	nitrite transmembrane transporter activity
AMD27_07760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMD27_07765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMD27_07770	COG0243	molybdopterin cofactor binding
AMD27_07780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AMD27_07790	COG0314	molybdopterin synthase activity
AMD27_07795	COG0521	Mo-molybdopterin cofactor biosynthetic process
AMD27_07795	COG0315	cyclic pyranopterin monophosphate synthase activity
AMD27_07800	COG0303	'Molybdopterin
AMD27_07805	COG0725	ABC transporter, periplasmic molybdate-binding protein
AMD27_07810	COG4149	molybdate abc transporter
AMD27_07815	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AMD27_07820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD27_07825	COG0183	Belongs to the thiolase family
AMD27_07830	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AMD27_07835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AMD27_07840	COG3135	benzoate transporter
AMD27_07845	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_07850	COG0543	2 iron, 2 sulfur cluster binding
AMD27_07850	COG0633	Ferredoxin
AMD27_07855	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AMD27_07860	COG4638	Rieske (2fe-2S)
AMD27_07870	COG4829	muconolactone delta-isomerase
AMD27_07875	COG4948	Mandelate Racemase Muconate Lactonizing
AMD27_07880	COG0583	DNA-binding transcription factor activity
AMD27_07905	COG1944	ATP diphosphatase activity
AMD27_07915	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_07920	COG3386	PFAM SMP-30 Gluconolaconase
AMD27_07930	COG0583	DNA-binding transcription factor activity
AMD27_07945	COG0431	NADPH-dependent FMN reductase
AMD27_07950	COG0798	PFAM Bile acid sodium symporter
AMD27_07960	COG0640	Transcriptional regulator
AMD27_08020	COG3619	membrane
AMD27_08025	COG3122	Protein conserved in bacteria
AMD27_08030	COG0668	transmembrane transport
AMD27_08035	COG1132	(ABC) transporter
AMD27_08090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AMD27_08095	COG3300	MHYT domain
AMD27_08095	COG5001	Diguanylate cyclase
AMD27_08100	COG0596	Alpha beta hydrolase
AMD27_08110	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AMD27_08115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMD27_08160	COG0583	DNA-binding transcription factor activity
AMD27_08165	COG1525	nuclease
AMD27_08175	COG2814	Major facilitator Superfamily
AMD27_08200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMD27_08205	COG0753	catalase activity
AMD27_08375	COG5410	chromosome segregation
AMD27_08410	COG1570	exodeoxyribonuclease VII activity
AMD27_08420	COG0494	nUDIX hydrolase
AMD27_08485	COG4197	protein conserved in bacteria, prophage-related
AMD27_08550	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AMD27_08590	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AMD27_08595	COG0511	ligase activity, forming carbon-carbon bonds
AMD27_08600	COG0439	Biotin carboxylase
AMD27_08610	COG3706	GGDEF domain
AMD27_08615	COG2814	Major facilitator Superfamily
AMD27_08650	COG0589	response to stress
AMD27_08680	COG1278	Cold shock
AMD27_08695	COG1960	acyl-CoA dehydrogenase activity
AMD27_08700	COG1960	acyl-CoA dehydrogenase activity
AMD27_08705	COG0456	acetyltransferase
AMD27_08710	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMD27_08715	COG2207	Transcriptional regulator
AMD27_08720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD27_08725	COG0776	regulation of translation
AMD27_08750	COG0822	iron-sulfur transferase activity
AMD27_08755	COG0316	Belongs to the HesB IscA family
AMD27_08765	COG0443	Heat shock 70 kDa protein
AMD27_08785	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AMD27_08800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMD27_08805	COG0702	epimerase
AMD27_08810	COG0268	Binds directly to 16S ribosomal RNA
AMD27_08820	COG1218	3'(2'),5'-bisphosphate nucleotidase
AMD27_08825	COG1011	Hydrolase
AMD27_08830	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AMD27_08835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AMD27_08840	COG2137	regulation of response to DNA damage stimulus
AMD27_08855	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMD27_08875	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD27_08890	COG0575	Belongs to the CDS family
AMD27_08895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AMD27_08900	COG0233	cytoplasmic translational termination
AMD27_08905	COG0528	UMP kinase activity
AMD27_08910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMD27_08915	COG3852	Histidine kinase
AMD27_08920	COG2204	response regulator
AMD27_08930	COG0372	Belongs to the citrate synthase family
AMD27_08950	COG0477	Major facilitator Superfamily
AMD27_08960	COG0542	response to heat
AMD27_08965	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AMD27_08995	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AMD27_09000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMD27_09025	COG0569	domain protein
AMD27_09030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AMD27_09040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMD27_09045	COG0583	DNA-binding transcription factor activity
AMD27_09070	COG0667	Aldo Keto reductase
AMD27_09075	COG0583	DNA-binding transcription factor activity
AMD27_09080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD27_09110	COG0772	Belongs to the SEDS family
AMD27_09115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMD27_09140	COG0148	phosphopyruvate hydratase activity
AMD27_09165	COG0737	Belongs to the 5'-nucleotidase family
AMD27_09180	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMD27_09180	COG1902	pentaerythritol trinitrate reductase activity
AMD27_09190	COG2267	carboxylic ester hydrolase activity
AMD27_09200	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMD27_09215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMD27_09225	COG0506	proline dehydrogenase activity
AMD27_09225	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AMD27_09225	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AMD27_09230	COG0308	aminopeptidase N
AMD27_09250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AMD27_09290	COG4303	Ethanolamine ammonia lyase large subunit
AMD27_09295	COG4302	ethanolamine ammonia-lyase activity
AMD27_09300	COG1064	alcohol dehydrogenase
AMD27_09310	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_09315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMD27_09315	COG0519	Catalyzes the synthesis of GMP from XMP
AMD27_09320	COG1280	lysine exporter protein (LysE YggA)
AMD27_09350	COG3706	GGDEF domain
AMD27_09350	COG0745	RESPONSE REGULATOR receiver
AMD27_09360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMD27_09400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AMD27_09400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMD27_09430	COG1024	Enoyl-CoA hydratase
AMD27_09435	COG1960	acyl-CoA dehydrogenase activity
AMD27_09440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMD27_09455	COG0583	DNA-binding transcription factor activity
AMD27_09460	COG0204	Acyl-transferase
AMD27_09510	COG1464	Belongs to the NlpA lipoprotein family
AMD27_09515	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMD27_09520	COG2011	ABC-type metal ion transport system permease component
AMD27_09525	COG0012	GTP binding
AMD27_09535	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AMD27_09570	COG0776	regulation of translation
AMD27_09590	COG0590	tRNA wobble adenosine to inosine editing
AMD27_09600	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AMD27_09620	COG2165	general secretion pathway protein
AMD27_09625	COG2165	general secretion pathway protein
AMD27_09635	COG0084	hydrolase, TatD family'
AMD27_09655	COG1663	tetraacyldisaccharide 4'-kinase activity
AMD27_09660	COG1132	(ABC) transporter
AMD27_09670	COG0811	peptide transport
AMD27_09675	COG1475	DNA binding
AMD27_09680	COG1192	Involved in chromosome partitioning
AMD27_09690	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMD27_09695	COG3178	'Phosphotransferase
AMD27_09705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD27_09710	COG1923	regulation of RNA biosynthetic process
AMD27_09715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMD27_09720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AMD27_09725	COG0802	atpase or kinase
AMD27_09735	COG0564	pseudouridine synthase activity
AMD27_09755	COG2707	UPF0756 membrane protein
AMD27_09760	COG0786	glutamate:sodium symporter activity
AMD27_09765	COG0786	glutamate:sodium symporter activity
AMD27_09800	COG2911	Protein conserved in bacteria
AMD27_09805	COG0729	surface antigen
AMD27_09810	COG0477	Major facilitator Superfamily
AMD27_09840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AMD27_09855	COG2890	protein-(glutamine-N5) methyltransferase activity
AMD27_09860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AMD27_09875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD27_09895	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AMD27_09900	COG0138	bifunctional purine biosynthesis protein purh
AMD27_09905	COG0151	Belongs to the GarS family
AMD27_09915	COG1464	Belongs to the NlpA lipoprotein family
AMD27_09920	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMD27_09925	COG2011	ABC-type metal ion transport system permease component
AMD27_10020	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AMD27_10025	COG1610	YqeY-like protein
AMD27_10040	COG4783	chaperone-mediated protein folding
AMD27_10070	COG0167	dihydroorotate dehydrogenase activity
AMD27_10095	COG0778	Nitroreductase
AMD27_10105	COG0513	Belongs to the DEAD box helicase family
AMD27_10110	COG1278	Cold shock
AMD27_10125	COG2363	Small membrane protein
AMD27_10140	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AMD27_10145	COG2249	NAD(P)H dehydrogenase (quinone) activity
AMD27_10150	COG0625	glutathione transferase activity
AMD27_10160	COG0659	secondary active sulfate transmembrane transporter activity
AMD27_10170	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AMD27_10200	COG0540	Belongs to the ATCase OTCase family
AMD27_10225	COG1045	serine acetyltransferase
AMD27_10235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AMD27_10240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMD27_10245	COG1765	OsmC-like protein
AMD27_10255	COG0667	Aldo Keto reductase
AMD27_10275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AMD27_10290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AMD27_10295	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMD27_10305	COG0527	aspartate kinase activity
AMD27_10315	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AMD27_10325	COG3038	cytochrome b561
AMD27_10335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AMD27_10340	COG2252	PERMEase
AMD27_10355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AMD27_10360	COG0251	oxidation-reduction process
AMD27_10365	COG1335	isochorismatase
AMD27_10375	COG0596	Alpha beta hydrolase
AMD27_10380	COG0583	DNA-binding transcription factor activity
AMD27_10405	COG0714	Associated with various cellular activities
AMD27_10410	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AMD27_10415	COG2879	small protein
AMD27_10420	COG1966	Carbon starvation protein
AMD27_10425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMD27_10445	COG0254	rRNA binding
AMD27_10465	COG1067	ATP-dependent peptidase activity
AMD27_10470	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AMD27_10475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMD27_10485	COG1388	LysM domain
AMD27_10485	COG4942	peptidase
AMD27_10505	COG1686	Belongs to the peptidase S11 family
AMD27_10510	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AMD27_10530	COG2132	Multicopper oxidase
AMD27_10550	COG2915	High frequency lysogenization protein hflD homolog
AMD27_10570	COG0616	signal peptide processing
AMD27_10595	COG0824	Thioesterase
AMD27_10620	COG0823	Involved in the tonB-independent uptake of proteins
AMD27_10640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMD27_10660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMD27_10695	COG1131	(ABC) transporter
AMD27_10700	COG0842	Transport permease protein
AMD27_10715	COG0772	Belongs to the SEDS family
AMD27_10720	COG2951	lytic endotransglycosylase activity
AMD27_10740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMD27_10745	COG0052	Belongs to the universal ribosomal protein uS2 family
AMD27_10755	COG0024	Methionine aminopeptidase
AMD27_10770	COG2175	clavaminate synthase activity
AMD27_10800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AMD27_10810	COG0183	Belongs to the thiolase family
AMD27_10845	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AMD27_10850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AMD27_10855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AMD27_10865	COG0281	malic enzyme
AMD27_10865	COG0280	phosphate acetyltransferase
AMD27_10890	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AMD27_10905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMD27_10910	COG1126	abc transporter atp-binding protein
AMD27_10920	COG0765	amino acid transport
AMD27_10930	COG3008	intermembrane lipid transfer
AMD27_10930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMD27_10940	COG2995	paraquat-inducible protein a
AMD27_11000	COG3210	domain, Protein
AMD27_11005	COG2831	hemolysin activation secretion protein
AMD27_11015	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMD27_11015	COG1902	pentaerythritol trinitrate reductase activity
AMD27_11025	COG0697	spore germination
AMD27_11030	COG0583	DNA-binding transcription factor activity
AMD27_11040	COG2203	Gaf domain
AMD27_11040	COG3706	GGDEF domain
AMD27_11040	COG4251	negative regulation of phosphorylation
AMD27_11040	COG5001	Diguanylate cyclase
AMD27_11045	COG0418	dihydroorotase activity
AMD27_11050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMD27_11115	COG1280	lysine exporter protein (LysE YggA)
AMD27_11120	COG1522	sequence-specific DNA binding
AMD27_11145	COG0019	diaminopimelate decarboxylase activity
AMD27_11155	COG1113	amino acid transport
AMD27_11160	COG1115	amino acid carrier protein
AMD27_11180	COG1794	racemase activity, acting on amino acids and derivatives
AMD27_11185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMD27_11195	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AMD27_11230	COG0772	Belongs to the SEDS family
AMD27_11240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMD27_11245	COG3161	chorismate lyase activity
AMD27_11270	COG0512	Glutamine amidotransferase of anthranilate synthase
AMD27_11275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AMD27_11290	COG0302	gtp cyclohydrolase
AMD27_11325	COG3739	integral membrane protein
AMD27_11340	COG1741	Belongs to the pirin family
AMD27_11355	COG3293	Transposase
AMD27_11360	COG0300	oxidoreductase activity
AMD27_11370	COG0583	DNA-binding transcription factor activity
AMD27_11420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMD27_11425	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AMD27_11440	COG0739	heme binding
AMD27_11440	COG1196	nuclear chromosome segregation
AMD27_11440	COG0741	lytic transglycosylase activity
AMD27_11445	COG0501	Belongs to the peptidase M48B family
AMD27_11465	COG0584	glycerophosphoryl diester phosphodiesterase
AMD27_11505	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AMD27_11510	COG1597	lipid kinase activity
AMD27_11520	COG0477	Major facilitator Superfamily
AMD27_11535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMD27_11575	COG2304	oxidoreductase activity
AMD27_11580	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMD27_11585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMD27_11605	COG0505	Belongs to the CarA family
AMD27_11610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AMD27_11625	COG0110	maltose O-acetyltransferase activity
AMD27_11645	COG0589	response to stress
AMD27_11670	COG2321	neutral zinc metallopeptidase
AMD27_11675	COG2354	Protein conserved in bacteria
AMD27_11690	COG2268	Band 7 protein
AMD27_11705	COG0204	Acyl-transferase
AMD27_11720	COG1253	flavin adenine dinucleotide binding
AMD27_11725	COG2851	Citrate transporter
AMD27_11750	COG2323	membrane
AMD27_11765	COG0004	ammonium transporteR
AMD27_11785	COG1752	Esterase of the alpha-beta hydrolase superfamily
AMD27_11800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMD27_11805	COG0142	geranyltranstransferase activity
AMD27_11815	COG2828	Protein conserved in bacteria
AMD27_11820	COG1113	amino acid transport
AMD27_11845	COG0560	Phosphoserine phosphatase
AMD27_11855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMD27_11860	COG1530	ribonuclease E activity
AMD27_11865	COG0424	maF-like protein
AMD27_11875	COG1792	Involved in formation and maintenance of cell shape
AMD27_11880	COG1077	Cell shape determining protein MreB Mrl
AMD27_11885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMD27_11895	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMD27_11920	COG0583	DNA-binding transcription factor activity
AMD27_11935	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AMD27_11950	COG1215	transferase activity, transferring glycosyl groups
AMD27_11955	COG1649	PFAM Uncharacterised BCR, COG1649
AMD27_11955	COG0726	polysaccharide deacetylase
AMD27_11965	COG4681	YaeQ
AMD27_11970	COG0523	cobalamin synthesis protein
AMD27_11980	COG1607	acyl-coa hydrolase
AMD27_11985	COG1752	Esterase of the alpha-beta hydrolase superfamily
AMD27_11990	COG0786	glutamate:sodium symporter activity
AMD27_12010	COG2814	Major facilitator Superfamily
AMD27_12015	COG1289	transmembrane transporter activity
AMD27_12020	COG1289	transmembrane transporter activity
AMD27_12030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AMD27_12085	COG1376	ErfK ybiS ycfS ynhG family protein
AMD27_12090	COG2832	Protein of unknown function (DUF454)
AMD27_12120	COG0840	transmembrane signaling receptor activity
AMD27_12145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD27_12190	COG0489	protein tyrosine kinase activity
AMD27_12210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD27_12210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMD27_12260	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AMD27_12265	COG2081	HI0933 family
AMD27_12275	COG0668	transmembrane transport
AMD27_12295	COG0583	DNA-binding transcription factor activity
AMD27_12300	COG3316	Transposase and inactivated derivatives
AMD27_12310	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AMD27_12320	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD27_12325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AMD27_12330	COG0713	ATP synthesis coupled electron transport
AMD27_12340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD27_12355	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AMD27_12365	COG0649	NAD binding
AMD27_12365	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD27_12375	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMD27_12385	COG2205	protein histidine kinase activity
AMD27_12390	COG0745	RESPONSE REGULATOR receiver
AMD27_12395	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMD27_12395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMD27_12400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMD27_12420	COG2814	Major facilitator Superfamily
AMD27_12440	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMD27_12445	COG1309	transcriptional regulator
AMD27_12465	COG1652	LysM domain
AMD27_12475	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_12495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AMD27_12500	COG1399	metal-binding, possibly nucleic acid-binding protein
AMD27_12505	COG3101	peptidyl-lysine hydroxylation
AMD27_12510	COG0009	L-threonylcarbamoyladenylate synthase
AMD27_12515	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AMD27_12520	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AMD27_12535	COG4106	trans-aconitate 2-methyltransferase activity
AMD27_12550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMD27_12550	COG2226	methyltransferase
AMD27_12550	COG0596	Alpha beta hydrolase
AMD27_12560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AMD27_12565	COG2193	ferroxidase activity
AMD27_12570	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AMD27_12575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMD27_12580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMD27_12585	COG3115	cell septum assembly
AMD27_12590	COG1196	nuclear chromosome segregation
AMD27_12600	COG0730	response to heat
AMD27_12625	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AMD27_12630	COG4137	Cytochrome C assembly protein
AMD27_12660	COG3501	Rhs element vgr protein
AMD27_12670	COG0494	nUDIX hydrolase
AMD27_12690	COG2824	Alkylphosphonate utilization operon protein PhnA
AMD27_12700	COG0564	pseudouridine synthase activity
AMD27_12730	COG0354	folic acid binding
AMD27_12755	COG1902	pentaerythritol trinitrate reductase activity
AMD27_12765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMD27_12780	COG2233	PERMEase
AMD27_12790	COG0833	amino acid
AMD27_12800	COG2885	chlorophyll binding
AMD27_12800	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AMD27_12810	COG0183	Belongs to the thiolase family
AMD27_12840	COG0133	tryptophan synthase activity
AMD27_12850	COG4206	TonB-dependent receptor
AMD27_12855	COG2096	Adenosyltransferase
AMD27_12875	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AMD27_12895	COG1113	amino acid transport
AMD27_12900	COG0745	RESPONSE REGULATOR receiver
AMD27_12905	COG2205	protein histidine kinase activity
AMD27_12915	COG1960	acyl-CoA dehydrogenase activity
AMD27_12920	COG1960	acyl-CoA dehydrogenase activity
AMD27_12930	COG3223	Belongs to the PsiE family
AMD27_12965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AMD27_12980	COG4641	Protein conserved in bacteria
AMD27_12980	COG0438	transferase activity, transferring glycosyl groups
AMD27_13005	COG0438	transferase activity, transferring glycosyl groups
AMD27_13015	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AMD27_13035	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AMD27_13040	COG0784	Response regulator, receiver
AMD27_13040	COG2205	protein histidine kinase activity
AMD27_13040	COG5002	protein histidine kinase activity
AMD27_13050	COG1764	response to oxidative stress
AMD27_13055	COG1846	Transcriptional regulator
AMD27_13085	COG4695	Portal protein
AMD27_13295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AMD27_13320	COG1862	Preprotein translocase
AMD27_13330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMD27_13350	COG1028	Short-chain dehydrogenase reductase Sdr
AMD27_13405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMD27_13415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMD27_13420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMD27_13440	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMD27_13460	COG1426	Protein conserved in bacteria
AMD27_13520	COG0440	acetolactate synthase activity
AMD27_13525	COG0028	Belongs to the TPP enzyme family
AMD27_13550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMD27_13555	COG1136	(ABC) transporter
AMD27_13555	COG0577	efflux transmembrane transporter activity
AMD27_13560	COG1538	Outer membrane efflux protein
AMD27_13575	COG3501	Rhs element vgr protein
AMD27_13595	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AMD27_13600	COG1162	GTPase activity
AMD27_13625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AMD27_13630	COG2003	Belongs to the UPF0758 family
AMD27_13635	COG3781	membrane
AMD27_13640	COG0613	PHP domain protein
AMD27_13650	COG2350	Protein conserved in bacteria
AMD27_13685	COG1607	acyl-coa hydrolase
AMD27_13695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD27_13695	COG3453	Protein conserved in bacteria
AMD27_13745	COG1183	phosphatidylcholine synthase activity
AMD27_13750	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AMD27_13785	COG0741	lytic transglycosylase activity
AMD27_13785	COG1196	nuclear chromosome segregation
AMD27_13785	COG0739	heme binding
AMD27_13795	COG1702	phosphate starvation-inducible protein PhoH
AMD27_13800	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AMD27_13805	COG0668	transmembrane transport
AMD27_13830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMD27_13845	COG1295	ribonuclease BN
AMD27_13850	COG0697	spore germination
AMD27_13855	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMD27_13900	COG0339	signal peptide processing
AMD27_13905	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AMD27_13935	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AMD27_13940	COG1960	acyl-CoA dehydrogenase activity
AMD27_13945	COG2072	flavoprotein involved in K transport
AMD27_13950	COG0203	ribosomal protein L17
AMD27_13955	COG0202	RNA polymerase activity
AMD27_13960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AMD27_13965	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AMD27_13975	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AMD27_13995	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AMD27_14010	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AMD27_14020	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AMD27_14030	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AMD27_14055	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AMD27_14060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AMD27_14075	COG0088	Forms part of the polypeptide exit tunnel
AMD27_14080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AMD27_14085	COG0051	transcription antitermination factor activity, RNA binding
AMD27_14090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMD27_14090	COG0519	Catalyzes the synthesis of GMP from XMP
AMD27_14095	COG0626	cystathionine gamma-synthase activity
AMD27_14100	COG0433	COG0433 Predicted ATPase
AMD27_14105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMD27_14105	COG1017	nitric oxide dioxygenase activity
AMD27_14110	COG1959	2 iron, 2 sulfur cluster binding
AMD27_14130	COG1301	dicarboxylic acid transport
AMD27_14135	COG1946	Acyl-CoA thioesterase
AMD27_14140	COG2937	Belongs to the GPAT DAPAT family
AMD27_14150	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AMD27_14155	COG1040	competence protein
AMD27_14170	COG0598	Magnesium transport protein CorA
AMD27_14185	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMD27_14190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMD27_14195	COG1127	ABC transporter
AMD27_14200	COG0513	Belongs to the DEAD box helicase family
AMD27_14240	COG1960	acyl-CoA dehydrogenase activity
AMD27_14255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMD27_14265	COG0534	Mate efflux family protein
AMD27_14320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMD27_14330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMD27_14345	COG0493	'glutamate synthase
AMD27_14345	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMD27_14355	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AMD27_14365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMD27_14380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AMD27_14390	COG0644	oxidoreductase
AMD27_14390	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AMD27_14405	COG3501	Rhs element vgr protein
AMD27_14410	COG0425	Belongs to the sulfur carrier protein TusA family
AMD27_14415	COG4535	Mg2 and Co2 transporter CorC
AMD27_14420	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AMD27_14440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AMD27_14450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AMD27_14460	COG0789	Transcriptional regulator
AMD27_14475	COG0598	Magnesium transport protein CorA
AMD27_14480	COG1185	polyribonucleotide nucleotidyltransferase activity
AMD27_14495	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AMD27_14500	COG1074	ATP-dependent DNA helicase activity
AMD27_14505	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AMD27_14535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMD27_14545	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AMD27_14560	COG2111	Na H antiporter
AMD27_14560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AMD27_14565	COG1006	Multisubunit Na H antiporter MnhC subunit
AMD27_14570	COG0651	ATP synthesis coupled electron transport
AMD27_14580	COG2212	antiporter activity
AMD27_14595	COG0493	'glutamate synthase
AMD27_14600	COG0069	glutamate synthase activity
AMD27_14600	COG0067	glutamate synthase
AMD27_14600	COG0070	glutamate synthase
AMD27_14615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMD27_14650	COG2226	methyltransferase
AMD27_14655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMD27_14660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AMD27_14665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AMD27_14680	COG0275	rRNA processing
AMD27_14685	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AMD27_14700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMD27_14720	COG0488	(ABC) transporter
AMD27_14730	COG4221	oxidoreductase activity
AMD27_14745	COG2183	response to ionizing radiation
AMD27_14750	COG0745	RESPONSE REGULATOR receiver
AMD27_14755	COG2205	protein histidine kinase activity
AMD27_14760	COG0427	acetyl-CoA hydrolase
AMD27_14795	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AMD27_14835	COG1278	Cold shock
AMD27_14840	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AMD27_14875	COG3158	transport of potassium into the cell
AMD27_14885	COG0582	viral genome integration into host DNA
AMD27_14925	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AMD27_14935	COG0450	alkyl hydroperoxide reductase
AMD27_14940	COG0629	single-stranded DNA binding
AMD27_14945	COG2814	Major facilitator Superfamily
AMD27_14955	COG0352	thiamine-phosphate diphosphorylase activity
AMD27_14955	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AMD27_14955	COG0351	phosphomethylpyrimidine kinase
AMD27_14970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMD27_14990	COG2814	Major facilitator Superfamily
AMD27_15045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMD27_15050	COG3162	membrane
AMD27_15055	COG2205	protein histidine kinase activity
AMD27_15055	COG0784	Response regulator, receiver
AMD27_15070	COG0431	NADPH-dependent FMN reductase
AMD27_15080	COG0307	riboflavin synthase, alpha
AMD27_15085	COG2223	nitrite transmembrane transporter activity
AMD27_15195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMD27_15200	COG0668	transmembrane transport
AMD27_15205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AMD27_15210	COG1519	Transferase
AMD27_15215	COG1902	pentaerythritol trinitrate reductase activity
AMD27_15250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AMD27_15275	COG2119	membrane
AMD27_15315	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AMD27_15325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMD27_15335	COG0189	ligase activity
AMD27_15345	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AMD27_15350	COG0708	Exodeoxyribonuclease III
AMD27_15370	COG2199	diguanylate cyclase activity
AMD27_15370	COG2203	Gaf domain
AMD27_15400	COG1247	-acetyltransferase
AMD27_15415	COG0410	ABC transporter
AMD27_15430	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMD27_15445	COG3150	esterase
AMD27_15460	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AMD27_15465	COG2918	glutathione biosynthetic process
AMD27_15480	COG2733	membrane
AMD27_15525	COG0436	Aminotransferase
AMD27_15530	COG0534	Mate efflux family protein
AMD27_15600	COG0560	Phosphoserine phosphatase
AMD27_15600	COG3830	Belongs to the UPF0237 family
AMD27_15625	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AMD27_15630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AMD27_15640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMD27_15735	COG0385	Bile acid
AMD27_15740	COG1335	isochorismatase
AMD27_15745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMD27_15755	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMD27_15760	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AMD27_15765	COG2133	pyrroloquinoline quinone binding
AMD27_15770	COG2983	Belongs to the UPF0260 family
AMD27_15800	COG2818	Glycosylase
AMD27_15815	COG0583	DNA-binding transcription factor activity
AMD27_15820	COG2814	Major facilitator Superfamily
AMD27_15845	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AMD27_15845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AMD27_15850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMD27_15855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMD27_15860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMD27_15865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMD27_15870	COG1116	anion transmembrane transporter activity
AMD27_15875	COG1309	transcriptional regulator
AMD27_15885	COG0196	riboflavin kinase activity
AMD27_15890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AMD27_15895	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AMD27_15900	COG1047	Peptidyl-prolyl cis-trans
AMD27_16050	COG2951	lytic endotransglycosylase activity
AMD27_16055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AMD27_16070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMD27_16110	COG0861	Integral membrane protein TerC family
AMD27_16125	COG0402	S-adenosylhomocysteine deaminase activity
AMD27_16140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AMD27_16145	COG2814	Major facilitator Superfamily
AMD27_16165	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AMD27_16170	COG0594	ribonuclease P activity
AMD27_16175	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AMD27_16485	COG2801	Transposase and inactivated derivatives
AMD27_16645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AMD27_16670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AMD27_16930	COG1199	ATP-dependent helicase activity
AMD27_16930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AMD27_17035	COG2801	Transposase and inactivated derivatives
AMD27_17480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMD27_17490	COG3047	cAMP biosynthetic process
AMD27_17490	COG2885	chlorophyll binding
AMD27_17625	COG0582	viral genome integration into host DNA
AMD27_17795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMD27_17795	COG0551	DNA topoisomerase type I activity
AMD27_17845	COG0406	alpha-ribazole phosphatase activity
AMD27_17890	COG1733	regulation of RNA biosynthetic process