locus-tag	class	description
TOL5_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TOL5_00020	COG0592	DNA-directed DNA polymerase activity
TOL5_00040	COG0187	DNA topoisomerase II activity
TOL5_00060	COG0488	(ABC) transporter
TOL5_00080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TOL5_00090	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TOL5_00100	COG0596	Alpha beta hydrolase
TOL5_00140	COG0657	acetylesterase activity
TOL5_00150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TOL5_00200	COG1012	belongs to the aldehyde dehydrogenase family
TOL5_00210	COG3738	Protein conserved in bacteria
TOL5_00220	COG0733	neurotransmitter:sodium symporter activity
TOL5_00250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TOL5_00280	COG0129	dihydroxy-acid dehydratase activity
TOL5_00320	COG0174	glutamine synthetase
TOL5_00350	COG1794	racemase activity, acting on amino acids and derivatives
TOL5_00360	COG1047	Peptidyl-prolyl cis-trans
TOL5_00370	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TOL5_00380	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TOL5_00390	COG0196	riboflavin kinase activity
TOL5_00420	COG2233	PERMEase
TOL5_00430	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TOL5_00440	COG1309	transcriptional regulator
TOL5_00450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOL5_00530	COG2814	Major facilitator Superfamily
TOL5_00540	COG0656	L-ascorbic acid biosynthetic process
TOL5_00550	COG0583	DNA-binding transcription factor activity
TOL5_00580	COG1064	alcohol dehydrogenase
TOL5_00590	COG2818	Glycosylase
TOL5_00610	COG0739	heme binding
TOL5_00620	COG1194	a g-specific adenine glycosylase
TOL5_00650	COG5487	UPF0391 membrane protein
TOL5_00660	COG2983	Belongs to the UPF0260 family
TOL5_00670	COG2819	hydrolase of the alpha beta superfamily
TOL5_00680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TOL5_00730	COG0633	Ferredoxin
TOL5_00780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TOL5_00790	COG1335	isochorismatase
TOL5_00800	COG0385	Bile acid
TOL5_00810	COG1683	Conserved Protein
TOL5_00840	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
TOL5_00840	COG2508	Transcriptional regulator
TOL5_00880	COG1113	amino acid transport
TOL5_00890	COG0640	Transcriptional regulator
TOL5_00900	COG1230	cation diffusion facilitator family transporter
TOL5_00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TOL5_00930	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TOL5_00940	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TOL5_00960	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TOL5_00990	COG3830	Belongs to the UPF0237 family
TOL5_00990	COG0560	Phosphoserine phosphatase
TOL5_01120	COG0534	Mate efflux family protein
TOL5_01130	COG0436	Aminotransferase
TOL5_01250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TOL5_01340	COG2733	membrane
TOL5_01360	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TOL5_01380	COG2918	glutathione biosynthetic process
TOL5_01420	COG3150	esterase
TOL5_01560	COG3706	GGDEF domain
TOL5_01600	COG1393	Belongs to the ArsC family
TOL5_01610	COG0708	Exodeoxyribonuclease III
TOL5_01640	COG2720	vancomycin resistance protein
TOL5_01650	COG2226	methyltransferase
TOL5_01670	COG0189	ligase activity
TOL5_01690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TOL5_01710	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TOL5_01790	COG2119	membrane
TOL5_01800	COG0426	domain, Protein
TOL5_01800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TOL5_01810	COG0727	PFAM Uncharacterised protein family (UPF0153)
TOL5_01840	COG0259	pyridoxamine-phosphate oxidase activity
TOL5_01850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TOL5_01940	COG2267	carboxylic ester hydrolase activity
TOL5_01950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TOL5_01980	COG2814	Major facilitator Superfamily
TOL5_02000	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TOL5_02000	COG0352	thiamine-phosphate diphosphorylase activity
TOL5_02000	COG0351	phosphomethylpyrimidine kinase
TOL5_02020	COG2814	Major facilitator Superfamily
TOL5_02030	COG0629	single-stranded DNA binding
TOL5_02040	COG0697	spore germination
TOL5_02050	COG2207	Transcriptional regulator
TOL5_02050	COG3708	Transcriptional regulator
TOL5_02090	COG2271	Major facilitator Superfamily
TOL5_02120	COG0583	DNA-binding transcription factor activity
TOL5_02130	COG1335	isochorismatase
TOL5_02150	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
TOL5_02230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TOL5_02350	COG3158	transport of potassium into the cell
TOL5_02380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TOL5_02420	COG0165	Argininosuccinate lyase
TOL5_02430	COG2972	Histidine kinase
TOL5_02430	COG0745	RESPONSE REGULATOR receiver
TOL5_02450	COG0181	hydroxymethylbilane synthase activity
TOL5_02580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TOL5_02610	COG0081	regulation of translation
TOL5_02640	COG0085	RNA polymerase activity
TOL5_02650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TOL5_02710	COG2056	Na+-H+ antiporter family
TOL5_02740	COG0326	Molecular chaperone. Has ATPase activity
TOL5_02770	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TOL5_02850	COG0183	Belongs to the thiolase family
TOL5_02860	COG1250	3-hydroxyacyl-CoA dehydrogenase
TOL5_02860	COG1024	Enoyl-CoA hydratase
TOL5_02920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TOL5_02980	COG0795	lipopolysaccharide-transporting ATPase activity
TOL5_02990	COG0795	lipopolysaccharide-transporting ATPase activity
TOL5_03000	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TOL5_03010	COG0793	Belongs to the peptidase S41A family
TOL5_03040	COG2197	response regulator
TOL5_03050	COG1686	Belongs to the peptidase S11 family
TOL5_03080	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TOL5_03110	COG4974	Belongs to the 'phage' integrase family
TOL5_03160	COG1132	(ABC) transporter
TOL5_03180	COG2249	NAD(P)H dehydrogenase (quinone) activity
TOL5_03200	COG1289	transmembrane transporter activity
TOL5_03240	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TOL5_03260	COG0497	DNA recombination
TOL5_03270	COG3123	guanosine phosphorylase activity
TOL5_03280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TOL5_03300	COG0237	dephospho-CoA kinase activity
TOL5_03360	COG0779	Required for maturation of 30S ribosomal subunits
TOL5_03370	COG0195	Participates in both transcription termination and antitermination
TOL5_03380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TOL5_03390	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TOL5_03400	COG1704	LemA family
TOL5_03410	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
TOL5_03460	COG3307	-O-antigen
TOL5_03470	COG4969	Belongs to the N-Me-Phe pilin family
TOL5_03480	COG3307	-O-antigen
TOL5_03520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TOL5_03530	COG1758	RNA polymerase activity
TOL5_03540	COG0194	GDP metabolic process
TOL5_03630	COG4969	Belongs to the N-Me-Phe pilin family
TOL5_03700	COG0228	four-way junction DNA binding
TOL5_03710	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TOL5_03730	COG0335	large ribosomal subunit rRNA binding
TOL5_03750	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
TOL5_03770	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
TOL5_03780	COG5380	lipid catabolic process
TOL5_03790	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TOL5_03840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TOL5_03860	COG5006	permease, DMT superfamily
TOL5_03870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TOL5_03880	COG0277	FAD linked oxidase domain protein
TOL5_03910	COG1181	Belongs to the D-alanine--D-alanine ligase family
TOL5_03970	COG2814	Major facilitator Superfamily
TOL5_03990	COG1289	transmembrane transporter activity
TOL5_04020	COG2032	superoxide dismutase activity
TOL5_04030	COG0628	permease
TOL5_04060	COG2226	methyltransferase
TOL5_04150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TOL5_04240	COG0752	glycyl-tRNA synthetase alpha subunit
TOL5_04260	COG0277	FAD linked oxidase domain protein
TOL5_04280	COG0517	IMP dehydrogenase activity
TOL5_04280	COG0617	tRNA 3'-terminal CCA addition
TOL5_04280	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TOL5_04290	COG1983	PspC domain protein
TOL5_04310	COG0318	PFAM AMP-dependent synthetase and ligase
TOL5_04320	COG1530	ribonuclease E activity
TOL5_04340	COG0546	phosphoglycolate phosphatase activity
TOL5_04350	COG2378	regulation of single-species biofilm formation
TOL5_04380	COG0583	DNA-binding transcription factor activity
TOL5_04460	COG0753	catalase activity
TOL5_04480	COG1960	acyl-CoA dehydrogenase activity
TOL5_04530	COG0494	nUDIX hydrolase
TOL5_04560	COG0583	DNA-binding transcription factor activity
TOL5_04590	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TOL5_04620	COG0473	3-isopropylmalate dehydrogenase activity
TOL5_04640	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TOL5_04670	COG0252	asparaginase activity
TOL5_04740	COG1560	Kdo2-lipid A biosynthetic process
TOL5_04790	COG0488	(ABC) transporter
TOL5_04800	COG2900	Belongs to the SlyX family
TOL5_04810	COG0583	DNA-binding transcription factor activity
TOL5_04820	COG1914	H( )-stimulated, divalent metal cation uptake system
TOL5_04860	COG4770	biotin carboxylase activity
TOL5_04880	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_04890	COG1733	regulation of RNA biosynthetic process
TOL5_04960	COG1929	Belongs to the glycerate kinase type-1 family
TOL5_05010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TOL5_05010	COG4651	solute:proton antiporter activity
TOL5_05060	COG0788	formyltetrahydrofolate deformylase activity
TOL5_05150	COG1607	acyl-coa hydrolase
TOL5_05180	COG1666	GTP binding
TOL5_05190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TOL5_05220	COG2350	Protein conserved in bacteria
TOL5_05240	COG0613	PHP domain protein
TOL5_05260	COG1702	phosphate starvation-inducible protein PhoH
TOL5_05270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOL5_05280	COG0739	heme binding
TOL5_05280	COG1196	nuclear chromosome segregation
TOL5_05280	COG0741	lytic transglycosylase activity
TOL5_05300	COG0039	L-malate dehydrogenase activity
TOL5_05340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TOL5_05350	COG1183	phosphatidylcholine synthase activity
TOL5_05380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TOL5_05390	COG1960	acyl-CoA dehydrogenase activity
TOL5_05400	COG1960	acyl-CoA dehydrogenase activity
TOL5_05410	COG1960	acyl-CoA dehydrogenase activity
TOL5_05450	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_05460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TOL5_05470	COG1960	acyl-CoA dehydrogenase activity
TOL5_05480	COG1024	Enoyl-CoA hydratase
TOL5_05490	COG4770	biotin carboxylase activity
TOL5_05500	COG0564	pseudouridine synthase activity
TOL5_05510	COG0477	Major facilitator Superfamily
TOL5_05520	COG1272	protein, Hemolysin III
TOL5_05560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TOL5_05570	COG1011	Hydrolase
TOL5_05750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TOL5_05790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TOL5_05800	COG3545	Serine hydrolase
TOL5_05840	COG0730	response to heat
TOL5_05860	COG1196	nuclear chromosome segregation
TOL5_05880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TOL5_05910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TOL5_05930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TOL5_05950	COG2267	carboxylic ester hydrolase activity
TOL5_05980	COG4106	trans-aconitate 2-methyltransferase activity
TOL5_06010	COG3422	double-strand break repair
TOL5_06040	COG1051	belongs to the nudix hydrolase family
TOL5_06070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TOL5_06080	COG2207	Transcriptional regulator
TOL5_06090	COG0454	-acetyltransferase
TOL5_06100	COG0456	acetyltransferase
TOL5_06120	COG0183	Belongs to the thiolase family
TOL5_06200	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TOL5_06210	COG0285	dihydrofolate synthase activity
TOL5_06260	COG0009	L-threonylcarbamoyladenylate synthase
TOL5_06270	COG3101	peptidyl-lysine hydroxylation
TOL5_06280	COG1399	metal-binding, possibly nucleic acid-binding protein
TOL5_06310	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_06320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TOL5_06330	COG1652	LysM domain
TOL5_06340	COG0450	alkyl hydroperoxide reductase
TOL5_06370	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TOL5_06400	COG2199	diguanylate cyclase activity
TOL5_06470	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TOL5_06480	COG3878	Protein conserved in bacteria
TOL5_06560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TOL5_06590	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TOL5_06640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TOL5_06640	COG2813	Specifically methylates the guanine in position
TOL5_06660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TOL5_06680	COG3128	pkhd-type hydroxylase
TOL5_06690	COG4774	siderophore transport
TOL5_06700	COG4774	siderophore transport
TOL5_06720	COG0740	serine-type endopeptidase activity
TOL5_06810	COG0857	belongs to the CobB CobQ family
TOL5_06810	COG0280	phosphate acetyltransferase
TOL5_06820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TOL5_06910	COG2832	Protein of unknown function (DUF454)
TOL5_06940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TOL5_06960	COG1289	transmembrane transporter activity
TOL5_06970	COG2814	Major facilitator Superfamily
TOL5_07000	COG0668	transmembrane transport
TOL5_07030	COG2081	HI0933 family
TOL5_07040	COG2515	1-aminocyclopropane-1-carboxylate deaminase
TOL5_07070	COG1309	transcriptional regulator
TOL5_07100	COG2226	methyltransferase
TOL5_07130	COG4716	Myosin-crossreactive antigen
TOL5_07180	COG1126	abc transporter atp-binding protein
TOL5_07190	COG0765	amino acid transport
TOL5_07200	COG0765	amino acid transport
TOL5_07210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TOL5_07260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TOL5_07280	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TOL5_07380	COG0494	nUDIX hydrolase
TOL5_07390	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TOL5_07400	COG1214	PFAM Peptidase M22, glycoprotease
TOL5_07410	COG1968	undecaprenyl-diphosphatase activity
TOL5_07440	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
TOL5_07450	COG4269	membrane
TOL5_07470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TOL5_07490	COG2132	Multicopper oxidase
TOL5_07540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TOL5_07550	COG1280	lysine exporter protein (LysE YggA)
TOL5_07580	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TOL5_07580	COG0351	phosphomethylpyrimidine kinase
TOL5_07580	COG0352	thiamine-phosphate diphosphorylase activity
TOL5_07630	COG0251	oxidation-reduction process
TOL5_07640	COG1113	amino acid transport
TOL5_07710	COG1981	membrane
TOL5_07730	COG3831	ATPase activity
TOL5_07750	COG3552	Protein containing von Willebrand factor type A (VWA) domain
TOL5_07770	COG0714	Associated with various cellular activities
TOL5_07790	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TOL5_07840	COG0456	acetyltransferase
TOL5_07860	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TOL5_07870	COG0500	methyltransferase
TOL5_07880	COG0492	ferredoxin-NADP+ reductase activity
TOL5_07890	COG1674	ftsk spoiiie
TOL5_07890	COG0531	amino acid
TOL5_07900	COG1280	lysine exporter protein (LysE YggA)
TOL5_07930	COG0204	Acyl-transferase
TOL5_07960	COG0523	cobalamin synthesis protein
TOL5_07970	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
TOL5_08050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TOL5_08050	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TOL5_08080	COG0183	Belongs to the thiolase family
TOL5_08130	COG1690	Belongs to the RtcB family
TOL5_08140	COG0833	amino acid
TOL5_08160	COG2233	PERMEase
TOL5_08170	COG1217	gtp-binding protein TYPA
TOL5_08180	COG1970	mechanosensitive ion channel activity
TOL5_08210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TOL5_08230	COG3659	wide pore channel activity
TOL5_08240	COG4772	TonB-dependent receptor
TOL5_08250	COG1902	pentaerythritol trinitrate reductase activity
TOL5_08350	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
TOL5_08390	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TOL5_08460	COG5002	protein histidine kinase activity
TOL5_08460	COG5001	Diguanylate cyclase
TOL5_08460	COG3447	MASE1 domain protein
TOL5_08510	COG2969	positive regulation of protein catabolic process
TOL5_08520	COG0625	glutathione transferase activity
TOL5_08540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TOL5_08550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TOL5_08580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TOL5_08590	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TOL5_08610	COG3385	transposase activity
TOL5_08670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TOL5_08690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TOL5_08700	COG1408	metallophosphoesterase
TOL5_08760	COG2824	Alkylphosphonate utilization operon protein PhnA
TOL5_08770	COG0590	tRNA wobble adenosine to inosine editing
TOL5_08830	COG4166	transmembrane transport
TOL5_08840	COG4166	transmembrane transport
TOL5_08870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TOL5_08900	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TOL5_08910	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TOL5_08950	COG1309	transcriptional regulator
TOL5_08960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TOL5_08980	COG2268	Band 7 protein
TOL5_08990	COG1585	Membrane protein implicated in regulation of membrane protease activity
TOL5_09020	COG3706	GGDEF domain
TOL5_09030	COG0477	Major facilitator Superfamily
TOL5_09050	COG0242	peptide deformylase activity
TOL5_09060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TOL5_09080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TOL5_09100	COG2271	Major facilitator Superfamily
TOL5_09140	COG0477	Major facilitator Superfamily
TOL5_09150	COG1012	belongs to the aldehyde dehydrogenase family
TOL5_09150	COG2030	dehydratase
TOL5_09160	COG3396	Phenylacetate-CoA oxygenase
TOL5_09170	COG3460	Phenylacetate-CoA oxygenase
TOL5_09180	COG3396	Phenylacetate-CoA oxygenase
TOL5_09190	COG2151	metal-sulfur cluster biosynthetic enzyme
TOL5_09200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TOL5_09210	COG1024	Enoyl-CoA hydratase
TOL5_09220	COG1024	Enoyl-CoA hydratase
TOL5_09230	COG1250	3-hydroxyacyl-CoA dehydrogenase
TOL5_09240	COG0183	Belongs to the thiolase family
TOL5_09250	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TOL5_09260	COG3327	negative regulation of DNA-templated transcription, initiation
TOL5_09300	COG2985	domain, Protein
TOL5_09340	COG1414	Transcriptional regulator
TOL5_09350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TOL5_09380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TOL5_09420	COG1733	regulation of RNA biosynthetic process
TOL5_09470	COG2771	luxR family
TOL5_09480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TOL5_09490	COG1566	PFAM secretion protein HlyD family protein
TOL5_09510	COG0789	Transcriptional regulator
TOL5_09540	COG1132	(ABC) transporter
TOL5_09540	COG2375	cellular response to nickel ion
TOL5_09560	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TOL5_09570	COG4605	iron ion homeostasis
TOL5_09580	COG4604	ABC transporter, ATP-binding protein
TOL5_09590	COG4607	ABC-type enterochelin transport system periplasmic component
TOL5_09600	COG4774	siderophore transport
TOL5_09640	COG2267	carboxylic ester hydrolase activity
TOL5_09650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TOL5_09660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TOL5_09670	COG1012	belongs to the aldehyde dehydrogenase family
TOL5_09690	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
TOL5_09710	COG1012	belongs to the aldehyde dehydrogenase family
TOL5_09720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TOL5_09760	COG3706	GGDEF domain
TOL5_09770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TOL5_09780	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TOL5_09800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TOL5_09810	COG0505	Belongs to the CarA family
TOL5_09840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TOL5_09880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TOL5_09890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOL5_09900	COG0745	RESPONSE REGULATOR receiver
TOL5_09920	COG5002	protein histidine kinase activity
TOL5_09940	COG3135	benzoate transporter
TOL5_09950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TOL5_09970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TOL5_09980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TOL5_09990	COG0022	dehydrogenase e1 component
TOL5_10000	COG0508	dehydrogenase complex catalyzes the overall conversion of
TOL5_10010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TOL5_10030	COG1063	alcohol dehydrogenase
TOL5_10070	COG0583	DNA-binding transcription factor activity
TOL5_10080	COG0473	3-isopropylmalate dehydrogenase activity
TOL5_10100	COG0657	acetylesterase activity
TOL5_10110	COG4638	Rieske (2fe-2S)
TOL5_10120	COG1012	belongs to the aldehyde dehydrogenase family
TOL5_10160	COG3539	Fimbrial protein
TOL5_10190	COG3121	Chaperone
TOL5_10240	COG3539	Fimbrial protein
TOL5_10280	COG3121	Chaperone
TOL5_10300	COG3539	Fimbrial protein
TOL5_10330	COG0523	cobalamin synthesis protein
TOL5_10350	COG1902	pentaerythritol trinitrate reductase activity
TOL5_10350	COG0446	pyridine nucleotide-disulphide oxidoreductase
TOL5_10360	COG4221	oxidoreductase activity
TOL5_10380	COG0789	Transcriptional regulator
TOL5_10410	COG2871	sodium ion transport
TOL5_10480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TOL5_10490	COG0183	Belongs to the thiolase family
TOL5_10500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TOL5_10510	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TOL5_10530	COG4829	muconolactone delta-isomerase
TOL5_10540	COG4948	Mandelate Racemase Muconate Lactonizing
TOL5_10550	COG0583	DNA-binding transcription factor activity
TOL5_10610	COG0583	DNA-binding transcription factor activity
TOL5_10620	COG3590	peptidase
TOL5_10650	COG2318	DinB family
TOL5_10690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TOL5_10710	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TOL5_10720	COG1077	Cell shape determining protein MreB Mrl
TOL5_10730	COG1792	Involved in formation and maintenance of cell shape
TOL5_10740	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
TOL5_10750	COG0424	maF-like protein
TOL5_10780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TOL5_10810	COG0560	Phosphoserine phosphatase
TOL5_10860	COG4181	ATPase activity
TOL5_10870	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TOL5_10890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TOL5_10920	COG0583	DNA-binding transcription factor activity
TOL5_10940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOL5_10950	COG1773	rubredoxin
TOL5_10960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TOL5_11020	COG2354	Protein conserved in bacteria
TOL5_11030	COG2321	neutral zinc metallopeptidase
TOL5_11080	COG1024	Enoyl-CoA hydratase
TOL5_11120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TOL5_11150	COG0625	glutathione transferase activity
TOL5_11170	COG1113	amino acid transport
TOL5_11190	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
TOL5_11210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TOL5_11220	COG0505	Belongs to the CarA family
TOL5_11260	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TOL5_11270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TOL5_11280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TOL5_11310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TOL5_11310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TOL5_11360	COG0300	oxidoreductase activity
TOL5_11370	COG2072	flavoprotein involved in K transport
TOL5_11440	COG2009	succinate dehydrogenase
TOL5_11450	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TOL5_11460	COG1053	succinate dehydrogenase
TOL5_11470	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TOL5_11500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TOL5_11520	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TOL5_11530	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_11590	COG0742	ribosomal rna small subunit methyltransferase
TOL5_11600	COG0768	penicillin binding
TOL5_11660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TOL5_11670	COG2878	Part of a membrane complex involved in electron transport
TOL5_11680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TOL5_11710	COG3384	dioxygenase
TOL5_11730	COG2234	aminopeptidase activity
TOL5_11790	COG1280	lysine exporter protein (LysE YggA)
TOL5_11880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TOL5_11880	COG3323	Protein of unknown function (DUF1653)
TOL5_11890	COG0778	Nitroreductase
TOL5_11900	COG1024	Enoyl-CoA hydratase
TOL5_11910	COG1051	belongs to the nudix hydrolase family
TOL5_11910	COG1056	cytidyltransferase-related domain
TOL5_11940	COG0625	glutathione transferase activity
TOL5_11990	COG0583	DNA-binding transcription factor activity
TOL5_12010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TOL5_12040	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TOL5_12050	COG0602	queuosine metabolic process
TOL5_12100	COG0583	DNA-binding transcription factor activity
TOL5_12110	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TOL5_12120	COG4208	sulfate ABC transporter
TOL5_12130	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
TOL5_12150	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TOL5_12160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TOL5_12170	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TOL5_12250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TOL5_12270	COG0671	phosphoesterase, PA-phosphatase related
TOL5_12280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TOL5_12290	COG0463	Glycosyl transferase, family 2
TOL5_12340	COG0571	ribonuclease III activity
TOL5_12350	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TOL5_12380	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TOL5_12400	COG0667	Aldo Keto reductase
TOL5_12420	COG0251	oxidation-reduction process
TOL5_12430	COG0583	DNA-binding transcription factor activity
TOL5_12450	COG0415	Belongs to the DNA photolyase family
TOL5_12460	COG1047	Peptidyl-prolyl cis-trans
TOL5_12470	COG1252	NADH dehydrogenase
TOL5_12480	COG1686	Belongs to the peptidase S11 family
TOL5_12500	COG2351	hydroxyisourate hydrolase activity
TOL5_12530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TOL5_12540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TOL5_12550	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TOL5_12620	COG0280	phosphate acetyltransferase
TOL5_12620	COG0281	malic enzyme
TOL5_12640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TOL5_12650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TOL5_12660	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TOL5_12700	COG0154	amidase activity
TOL5_12770	COG1960	acyl-CoA dehydrogenase activity
TOL5_12860	COG0583	DNA-binding transcription factor activity
TOL5_12870	COG0697	spore germination
TOL5_12890	COG2186	Transcriptional regulator
TOL5_12910	COG0277	FAD linked oxidase domain protein
TOL5_12930	COG0446	pyridine nucleotide-disulphide oxidoreductase
TOL5_12930	COG1902	pentaerythritol trinitrate reductase activity
TOL5_12940	COG0582	viral genome integration into host DNA
TOL5_13150	COG2814	Major facilitator Superfamily
TOL5_13170	COG1230	cation diffusion facilitator family transporter
TOL5_13200	COG2059	Chromate
TOL5_13240	COG0582	viral genome integration into host DNA
TOL5_13400	COG2223	nitrite transmembrane transporter activity
TOL5_13410	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TOL5_13420	COG1877	trehalose-phosphatase activity
TOL5_13490	COG2323	membrane
TOL5_13520	COG1058	Belongs to the CinA family
TOL5_13520	COG1546	Belongs to the CinA family
TOL5_13560	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_13600	COG0582	viral genome integration into host DNA
TOL5_13640	COG2831	hemolysin activation secretion protein
TOL5_13650	COG2994	toxin metabolic process
TOL5_13660	COG3210	domain, Protein
TOL5_13820	COG2826	transposase and inactivated derivatives, IS30 family
TOL5_13930	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_13940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TOL5_13960	COG1012	belongs to the aldehyde dehydrogenase family
TOL5_13980	COG0546	phosphoglycolate phosphatase activity
TOL5_14020	COG1129	ABC transporter
TOL5_14030	COG1172	Belongs to the binding-protein-dependent transport system permease family
TOL5_14060	COG1063	alcohol dehydrogenase
TOL5_14210	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TOL5_14220	COG1012	belongs to the aldehyde dehydrogenase family
TOL5_14240	COG1113	amino acid transport
TOL5_14270	COG3539	Fimbrial protein
TOL5_14280	COG3121	Chaperone
TOL5_14370	COG1846	Transcriptional regulator
TOL5_14400	COG1228	amidohydrolase
TOL5_14430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TOL5_14440	COG1012	belongs to the aldehyde dehydrogenase family
TOL5_14450	COG0531	amino acid
TOL5_14460	COG2957	Belongs to the agmatine deiminase family
TOL5_14470	COG1116	anion transmembrane transporter activity
TOL5_14470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TOL5_14490	COG2223	nitrite transmembrane transporter activity
TOL5_14500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOL5_14500	COG2146	nitrite reductase [NAD(P)H] activity
TOL5_14510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOL5_14520	COG0243	molybdopterin cofactor binding
TOL5_14540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TOL5_14560	COG0314	molybdopterin synthase activity
TOL5_14570	COG0315	cyclic pyranopterin monophosphate synthase activity
TOL5_14570	COG0521	Mo-molybdopterin cofactor biosynthetic process
TOL5_14580	COG0303	'Molybdopterin
TOL5_14590	COG0725	ABC transporter, periplasmic molybdate-binding protein
TOL5_14600	COG4149	molybdate abc transporter
TOL5_14610	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TOL5_14620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TOL5_14640	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TOL5_14650	COG0583	DNA-binding transcription factor activity
TOL5_14680	COG0439	Biotin carboxylase
TOL5_14690	COG2249	NAD(P)H dehydrogenase (quinone) activity
TOL5_14700	COG1733	regulation of RNA biosynthetic process
TOL5_14710	COG0864	Transcriptional regulator
TOL5_14770	COG1116	anion transmembrane transporter activity
TOL5_14810	COG0596	Alpha beta hydrolase
TOL5_14830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TOL5_14840	COG1335	isochorismatase
TOL5_14850	COG0251	oxidation-reduction process
TOL5_14860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TOL5_14870	COG2233	PERMEase
TOL5_14900	COG0235	Class ii aldolase
TOL5_14910	COG1741	Belongs to the pirin family
TOL5_14940	COG3739	integral membrane protein
TOL5_14980	COG0531	amino acid
TOL5_14990	COG4303	Ethanolamine ammonia lyase large subunit
TOL5_15010	COG1960	acyl-CoA dehydrogenase activity
TOL5_15020	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_15080	COG0302	gtp cyclohydrolase
TOL5_15120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TOL5_15130	COG0512	Glutamine amidotransferase of anthranilate synthase
TOL5_15230	COG0174	glutamine synthetase
TOL5_15270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TOL5_15320	COG0823	Involved in the tonB-independent uptake of proteins
TOL5_15380	COG0824	Thioesterase
TOL5_15450	COG4771	TonB-dependent receptor
TOL5_15530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TOL5_15530	COG0047	phosphoribosylformylglycinamidine synthase activity
TOL5_15570	COG1301	dicarboxylic acid transport
TOL5_15600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOL5_15640	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TOL5_15740	COG1960	acyl-CoA dehydrogenase activity
TOL5_15750	COG0183	Belongs to the thiolase family
TOL5_15760	COG0427	acetyl-CoA hydrolase
TOL5_15780	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TOL5_15780	COG0517	IMP dehydrogenase activity
TOL5_15790	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TOL5_15810	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
TOL5_15820	COG1137	ATPase activity
TOL5_15870	COG4122	O-methyltransferase activity
TOL5_15910	COG0573	inorganic phosphate transmembrane transporter activity
TOL5_15930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TOL5_15940	COG1301	dicarboxylic acid transport
TOL5_15950	COG0616	signal peptide processing
TOL5_15960	COG1960	acyl-CoA dehydrogenase activity
TOL5_15980	COG0693	protein deglycase activity
TOL5_16000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TOL5_16040	COG0430	RNA-3'-phosphate cyclase activity
TOL5_16080	COG1690	Belongs to the RtcB family
TOL5_16110	COG1234	tRNA 3'-trailer cleavage
TOL5_16120	COG4650	regulator
TOL5_16140	COG3022	response to hydroperoxide
TOL5_16310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOL5_16330	COG2011	ABC-type metal ion transport system permease component
TOL5_16340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TOL5_16350	COG1464	Belongs to the NlpA lipoprotein family
TOL5_16370	COG0151	Belongs to the GarS family
TOL5_16380	COG0138	bifunctional purine biosynthesis protein purh
TOL5_16390	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
TOL5_16470	COG2308	Evidence 4 Homologs of previously reported genes of
TOL5_16490	COG1305	Transglutaminase-like
TOL5_16530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TOL5_16550	COG0305	Participates in initiation and elongation during chromosome replication
TOL5_16570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TOL5_16580	COG0360	Binds together with S18 to 16S ribosomal RNA
TOL5_16620	COG0109	protoheme IX farnesyltransferase activity
TOL5_16630	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TOL5_16640	COG1845	cytochrome c oxidase, subunit III
TOL5_16650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TOL5_16660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TOL5_16730	COG4682	membrane
TOL5_16740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TOL5_16790	COG2890	protein-(glutamine-N5) methyltransferase activity
TOL5_16800	COG3781	membrane
TOL5_16810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TOL5_16820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TOL5_16860	COG1960	acyl-CoA dehydrogenase activity
TOL5_16870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TOL5_16890	COG4585	Histidine kinase
TOL5_16910	COG0659	secondary active sulfate transmembrane transporter activity
TOL5_16930	COG2249	NAD(P)H dehydrogenase (quinone) activity
TOL5_16940	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
TOL5_17000	COG2363	Small membrane protein
TOL5_17040	COG0513	Belongs to the DEAD box helicase family
TOL5_17060	COG0778	Nitroreductase
TOL5_17110	COG0167	dihydroorotate dehydrogenase activity
TOL5_17170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TOL5_17170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TOL5_17180	COG1254	Belongs to the acylphosphatase family
TOL5_17240	COG1280	lysine exporter protein (LysE YggA)
TOL5_17280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TOL5_17310	COG2353	YceI-like domain
TOL5_17330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TOL5_17350	COG3042	response to heat
TOL5_17360	COG0519	Catalyzes the synthesis of GMP from XMP
TOL5_17360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TOL5_17370	COG1309	transcriptional regulator
TOL5_17410	COG0583	DNA-binding transcription factor activity
TOL5_17450	COG3284	Transcriptional regulator
TOL5_17480	COG1454	alcohol dehydrogenase
TOL5_17530	COG0183	Belongs to the thiolase family
TOL5_17630	COG0824	Thioesterase
TOL5_17650	COG1454	alcohol dehydrogenase
TOL5_17730	COG0537	adenosine 5'-monophosphoramidase activity
TOL5_17790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TOL5_17830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TOL5_17850	COG0133	tryptophan synthase activity
TOL5_17870	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TOL5_17870	COG0517	IMP dehydrogenase activity
TOL5_17930	COG0612	Peptidase, M16
TOL5_17940	COG0552	protein localization to endoplasmic reticulum
TOL5_18000	COG1253	flavin adenine dinucleotide binding
TOL5_18040	COG1114	Component of the transport system for branched-chain amino acids
TOL5_18050	COG0024	Methionine aminopeptidase
TOL5_18070	COG3135	benzoate transporter
TOL5_18100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TOL5_18140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TOL5_18150	COG2119	membrane
TOL5_18160	COG2194	sulfuric ester hydrolase activity
TOL5_18260	COG1294	oxidase, subunit
TOL5_18290	COG2249	NAD(P)H dehydrogenase (quinone) activity
TOL5_18320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TOL5_18330	COG2153	protein acetylation
TOL5_18370	COG1846	Transcriptional regulator
TOL5_18380	COG1132	(ABC) transporter
TOL5_18390	COG1304	FMN binding
TOL5_18420	COG4773	Receptor
TOL5_18430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOL5_18460	COG3753	Protein conserved in bacteria
TOL5_18490	COG3852	Histidine kinase
TOL5_18520	COG0233	cytoplasmic translational termination
TOL5_18530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TOL5_18540	COG0575	Belongs to the CDS family
TOL5_18570	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TOL5_18590	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOL5_18610	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOL5_18640	COG2137	regulation of response to DNA damage stimulus
TOL5_18650	COG0318	PFAM AMP-dependent synthetase and ligase
TOL5_18660	COG4221	oxidoreductase activity
TOL5_18670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TOL5_18680	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TOL5_18690	COG1011	Hydrolase
TOL5_18710	COG1218	3'(2'),5'-bisphosphate nucleotidase
TOL5_18750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TOL5_18760	COG0730	response to heat
TOL5_18800	COG2199	diguanylate cyclase activity
TOL5_18820	COG0439	Biotin carboxylase
TOL5_18830	COG0511	ligase activity, forming carbon-carbon bonds
TOL5_18910	COG1846	Transcriptional regulator
TOL5_18930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TOL5_18960	COG0308	aminopeptidase N
TOL5_19030	COG0506	proline dehydrogenase activity
TOL5_19030	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
TOL5_19030	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
TOL5_19050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TOL5_19060	COG1027	Aspartate ammonia-lyase
TOL5_19080	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TOL5_19150	COG0477	Major facilitator Superfamily
TOL5_19170	COG3179	chitinase
TOL5_19210	COG3135	benzoate transporter
TOL5_19220	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_19230	COG0633	Ferredoxin
TOL5_19230	COG0543	2 iron, 2 sulfur cluster binding
TOL5_19240	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
TOL5_19250	COG4638	Rieske (2fe-2S)
TOL5_19270	COG0583	DNA-binding transcription factor activity
TOL5_19280	COG2814	Major facilitator Superfamily
TOL5_19320	COG1902	pentaerythritol trinitrate reductase activity
TOL5_19320	COG0446	pyridine nucleotide-disulphide oxidoreductase
TOL5_19370	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TOL5_19390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TOL5_19410	COG0772	Belongs to the SEDS family
TOL5_19420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TOL5_19520	COG0583	DNA-binding transcription factor activity
TOL5_19530	COG0667	Aldo Keto reductase
TOL5_19590	COG1309	transcriptional regulator
TOL5_19600	COG0596	Alpha beta hydrolase
TOL5_19600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TOL5_19600	COG2226	methyltransferase
TOL5_19610	COG2937	Belongs to the GPAT DAPAT family
TOL5_19620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TOL5_19780	COG4589	Belongs to the CDS family
TOL5_19810	COG0671	phosphoesterase, PA-phosphatase related
TOL5_19810	COG2453	phosphatase
TOL5_19820	COG2267	carboxylic ester hydrolase activity
TOL5_19830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TOL5_19920	COG2223	nitrite transmembrane transporter activity
TOL5_19960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TOL5_19990	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TOL5_20030	COG0640	Transcriptional regulator
TOL5_20050	COG3122	Protein conserved in bacteria
TOL5_20060	COG3619	membrane
TOL5_20090	COG0640	Transcriptional regulator
TOL5_20150	COG3300	MHYT domain
TOL5_20150	COG5001	Diguanylate cyclase
TOL5_20160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TOL5_20170	COG0509	glycine decarboxylation via glycine cleavage system
TOL5_20210	COG1960	acyl-CoA dehydrogenase activity
TOL5_20220	COG1960	acyl-CoA dehydrogenase activity
TOL5_20320	COG0589	response to stress
TOL5_20340	COG0830	nickel cation binding
TOL5_20370	COG0829	nickel cation binding
TOL5_20410	COG0804	urea catabolic process
TOL5_20480	COG2351	hydroxyisourate hydrolase activity
TOL5_20500	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
TOL5_20510	COG4266	Belongs to the allantoicase family
TOL5_20520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TOL5_20530	COG0583	DNA-binding transcription factor activity
TOL5_20560	COG1944	ATP diphosphatase activity
TOL5_20600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TOL5_20610	COG1960	acyl-CoA dehydrogenase activity
TOL5_20620	COG1024	Enoyl-CoA hydratase
TOL5_20640	COG0477	Major facilitator Superfamily
TOL5_20660	COG1881	PFAM PEBP family protein
TOL5_20670	COG2207	Transcriptional regulator
TOL5_20700	COG4774	siderophore transport
TOL5_20720	COG2814	Major facilitator Superfamily
TOL5_20840	COG0583	DNA-binding transcription factor activity
TOL5_20850	COG1380	Effector of murein hydrolase LrgA
TOL5_20860	COG1346	cytolysis
TOL5_20870	COG2814	Major facilitator Superfamily
TOL5_20900	COG0697	spore germination
TOL5_20910	COG0596	Alpha beta hydrolase
TOL5_20930	COG1448	Aminotransferase
TOL5_20940	COG0488	(ABC) transporter
TOL5_21010	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
TOL5_21020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TOL5_21040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TOL5_21050	COG0697	spore germination
TOL5_21180	COG0583	DNA-binding transcription factor activity
TOL5_21190	COG3152	Membrane
TOL5_21200	COG3293	Transposase
TOL5_21210	COG1294	oxidase, subunit
TOL5_21220	COG1271	oxidase subunit
TOL5_21250	COG2207	Transcriptional regulator
TOL5_21260	COG1960	acyl-CoA dehydrogenase activity
TOL5_21350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TOL5_21370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TOL5_21450	COG1278	Cold shock
TOL5_21600	COG0739	heme binding
TOL5_21850	COG1278	Cold shock
TOL5_21990	COG2199	diguanylate cyclase activity
TOL5_21990	COG2203	Gaf domain
TOL5_22100	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
TOL5_22160	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TOL5_22170	COG2207	Transcriptional regulator
TOL5_22190	COG0776	regulation of translation
TOL5_22220	COG1959	2 iron, 2 sulfur cluster binding
TOL5_22240	COG0822	iron-sulfur transferase activity
TOL5_22250	COG0316	Belongs to the HesB IscA family
TOL5_22310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TOL5_22370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TOL5_22380	COG0702	epimerase
TOL5_22400	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TOL5_22450	COG3196	Protein conserved in bacteria
TOL5_22500	COG0126	phosphoglycerate kinase activity
TOL5_22520	COG0424	maF-like protein
TOL5_22530	COG2850	peptidyl-arginine hydroxylation
TOL5_22550	COG0069	glutamate synthase activity
TOL5_22600	COG1535	isochorismatase
TOL5_22600	COG3433	isochorismatase activity
TOL5_22610	COG0372	Belongs to the citrate synthase family
TOL5_22690	COG2814	Major facilitator Superfamily
TOL5_22700	COG1960	acyl-CoA dehydrogenase activity
TOL5_22710	COG0583	DNA-binding transcription factor activity
TOL5_22730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TOL5_22740	COG0583	DNA-binding transcription factor activity
TOL5_22790	COG0657	acetylesterase activity
TOL5_22790	COG2755	lipolytic protein G-D-S-L family
TOL5_22800	COG0542	response to heat
TOL5_22810	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TOL5_22840	COG3706	GGDEF domain
TOL5_22910	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TOL5_22920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TOL5_22950	COG0569	domain protein
TOL5_22960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TOL5_22970	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TOL5_23000	COG2431	L-lysine efflux transmembrane transporter activity
TOL5_23010	COG0284	orotidine-5'-phosphate decarboxylase activity
TOL5_23080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TOL5_23100	COG0590	tRNA wobble adenosine to inosine editing
TOL5_23120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TOL5_23140	COG3156	type II secretion system protein K
TOL5_23190	COG0084	hydrolase, TatD family'
TOL5_23230	COG1663	tetraacyldisaccharide 4'-kinase activity
TOL5_23240	COG1132	(ABC) transporter
TOL5_23260	COG0811	peptide transport
TOL5_23270	COG1475	DNA binding
TOL5_23280	COG1192	Involved in chromosome partitioning
TOL5_23300	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TOL5_23310	COG3178	'Phosphotransferase
TOL5_23330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TOL5_23430	COG1923	regulation of RNA biosynthetic process
TOL5_23450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TOL5_23460	COG0802	atpase or kinase
TOL5_23500	COG1187	pseudouridine synthase activity
TOL5_23510	COG0492	ferredoxin-NADP+ reductase activity
TOL5_23520	COG1959	2 iron, 2 sulfur cluster binding
TOL5_23530	COG2707	UPF0756 membrane protein
TOL5_23580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TOL5_23730	COG1464	Belongs to the NlpA lipoprotein family
TOL5_23740	COG1464	Belongs to the NlpA lipoprotein family
TOL5_23750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TOL5_23760	COG2011	ABC-type metal ion transport system permease component
TOL5_23770	COG0012	GTP binding
TOL5_23820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TOL5_23870	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TOL5_23900	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TOL5_23980	COG1917	Cupin 2, conserved barrel domain protein
TOL5_23980	COG2207	Transcriptional regulator
TOL5_23990	COG0386	Belongs to the glutathione peroxidase family
TOL5_24000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TOL5_24010	COG0436	Aminotransferase
TOL5_24070	COG1610	YqeY-like protein
TOL5_24090	COG4783	chaperone-mediated protein folding
TOL5_24130	COG0318	PFAM AMP-dependent synthetase and ligase
TOL5_24200	COG0729	surface antigen
TOL5_24210	COG0477	Major facilitator Superfamily
TOL5_24250	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TOL5_24270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TOL5_24310	COG0204	Acyl-transferase
TOL5_24340	COG1309	transcriptional regulator
TOL5_24450	COG3209	COG3209 Rhs family protein
TOL5_24520	COG0582	viral genome integration into host DNA
TOL5_24550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TOL5_24630	COG4245	von Willebrand factor, type A
TOL5_24640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TOL5_24660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TOL5_24670	COG1113	amino acid transport
TOL5_24680	COG0697	spore germination
TOL5_24700	COG1160	GTP binding
TOL5_24770	COG4735	regulation of single-species biofilm formation
TOL5_25040	COG3340	Belongs to the peptidase S51 family
TOL5_25080	COG0583	DNA-binding transcription factor activity
TOL5_25100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TOL5_25120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TOL5_25180	COG0540	Belongs to the ATCase OTCase family
TOL5_25270	COG0542	response to heat
TOL5_25290	COG1045	serine acetyltransferase
TOL5_25310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TOL5_25320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TOL5_25340	COG1765	OsmC-like protein
TOL5_25360	COG0667	Aldo Keto reductase
TOL5_25400	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TOL5_25430	COG1335	isochorismatase
TOL5_25440	COG1522	sequence-specific DNA binding
TOL5_25450	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
TOL5_25460	COG1522	sequence-specific DNA binding
TOL5_25500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TOL5_25540	COG0527	aspartate kinase activity
TOL5_25560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TOL5_25580	COG3038	cytochrome b561
TOL5_25600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TOL5_25610	COG2252	PERMEase
TOL5_25640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TOL5_25710	COG4771	TonB-dependent receptor
TOL5_25740	COG0714	Associated with various cellular activities
TOL5_25760	COG2879	small protein
TOL5_25770	COG1966	Carbon starvation protein
TOL5_25780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TOL5_25790	COG1509	lysine 2,3-aminomutase activity
TOL5_25860	COG1067	ATP-dependent peptidase activity
TOL5_25870	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TOL5_25880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TOL5_25900	COG4942	peptidase
TOL5_25910	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TOL5_25940	COG1686	Belongs to the peptidase S11 family
TOL5_25950	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TOL5_26020	COG2915	High frequency lysogenization protein hflD homolog
TOL5_26050	COG1733	regulation of RNA biosynthetic process
TOL5_26060	COG0702	epimerase
TOL5_26130	COG2962	Rard protein
TOL5_26150	COG0556	nucleotide-excision repair
TOL5_26170	COG3300	MHYT domain
TOL5_26170	COG5001	Diguanylate cyclase
TOL5_26200	COG0436	Aminotransferase
TOL5_26240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOL5_26260	COG2223	nitrite transmembrane transporter activity
TOL5_26290	COG0477	Major facilitator Superfamily
TOL5_26350	COG0028	Belongs to the TPP enzyme family
TOL5_26380	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_26390	COG2267	carboxylic ester hydrolase activity
TOL5_26410	COG2271	Major facilitator Superfamily
TOL5_26520	COG0642	Histidine kinase
TOL5_26550	COG0583	DNA-binding transcription factor activity
TOL5_26650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TOL5_26670	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_26720	COG0154	amidase activity
TOL5_26740	COG1250	3-hydroxyacyl-CoA dehydrogenase
TOL5_26760	COG2207	Transcriptional regulator
TOL5_26760	COG3708	Transcriptional regulator
TOL5_26770	COG2814	Major facilitator Superfamily
TOL5_26790	COG2610	gluconate transmembrane transporter activity
TOL5_26800	COG1454	alcohol dehydrogenase
TOL5_26850	COG2271	Major facilitator Superfamily
TOL5_26860	COG0697	spore germination
TOL5_26880	COG1012	belongs to the aldehyde dehydrogenase family
TOL5_26890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TOL5_26900	COG2271	Major facilitator Superfamily
TOL5_26920	COG2186	Transcriptional regulator
TOL5_26930	COG1785	Belongs to the alkaline phosphatase family
TOL5_26970	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_26970	COG3321	synthase
TOL5_26970	COG0604	alcohol dehydrogenase
TOL5_26980	COG1309	transcriptional regulator
TOL5_26990	COG0477	Major facilitator Superfamily
TOL5_27020	COG2814	Major facilitator Superfamily
TOL5_27030	COG1309	transcriptional regulator
TOL5_27050	COG5487	UPF0391 membrane protein
TOL5_27110	COG0693	protein deglycase activity
TOL5_27150	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TOL5_27150	COG3008	intermembrane lipid transfer
TOL5_27160	COG2995	paraquat-inducible protein a
TOL5_27210	COG0745	RESPONSE REGULATOR receiver
TOL5_27240	COG0642	Histidine kinase
TOL5_27270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TOL5_27340	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TOL5_27360	COG0076	glutamate decarboxylase activity
TOL5_27370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TOL5_27390	COG4772	TonB-dependent receptor
TOL5_27450	COG1309	transcriptional regulator
TOL5_27480	COG1022	Amp-dependent synthetase and ligase
TOL5_27570	COG0789	Transcriptional regulator
TOL5_27580	COG0798	PFAM Bile acid sodium symporter
TOL5_27590	COG0640	Transcriptional regulator
TOL5_27610	COG0826	peptidase U32
TOL5_27620	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TOL5_27630	COG0583	DNA-binding transcription factor activity
TOL5_27640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TOL5_27650	COG3634	alkyl hydroperoxide reductase activity
TOL5_27730	COG0628	permease
TOL5_27750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TOL5_27790	COG0658	competence protein
TOL5_27790	COG2333	competence protein COMEC
TOL5_27800	COG1136	(ABC) transporter
TOL5_27850	COG2072	flavoprotein involved in K transport
TOL5_27900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TOL5_27910	COG0010	Belongs to the arginase family
TOL5_27930	COG1113	amino acid transport
TOL5_27970	COG2188	Transcriptional regulator
TOL5_27980	COG2831	hemolysin activation secretion protein
TOL5_27990	COG3210	domain, Protein
TOL5_28060	COG1643	Atp-dependent helicase
TOL5_28110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TOL5_28170	COG2070	2-Nitropropane dioxygenase
TOL5_28180	COG2318	DinB family
TOL5_28250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TOL5_28500	COG4387	Mu-like prophage protein GP36
TOL5_28580	COG5410	chromosome segregation
TOL5_28740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TOL5_28890	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TOL5_28910	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TOL5_28930	COG1301	dicarboxylic acid transport
TOL5_28940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TOL5_28960	COG3139	Protein of unknown function (DUF1315)
TOL5_28970	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TOL5_28980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TOL5_29000	COG0494	nUDIX hydrolase
TOL5_29020	COG0642	Histidine kinase
TOL5_29040	COG3111	PFAM Bacterial OB fold (BOF) protein
TOL5_29050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TOL5_29140	COG0352	thiamine-phosphate diphosphorylase activity
TOL5_29170	COG3025	triphosphatase activity
TOL5_29180	COG1720	tRNA m6t6A37 methyltransferase activity
TOL5_29210	COG0612	Peptidase, M16
TOL5_29250	COG1823	symporter activity
TOL5_29260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TOL5_29280	COG2233	PERMEase
TOL5_29300	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TOL5_29330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TOL5_29490	COG1476	TRANSCRIPTIONal
TOL5_29560	COG0456	acetyltransferase
TOL5_29560	COG1846	Transcriptional regulator
TOL5_29570	COG3328	transposase activity
TOL5_29580	COG3328	transposase activity
TOL5_29600	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TOL5_29610	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TOL5_29630	COG3192	ethanolamine utilization protein
TOL5_30050	COG4197	protein conserved in bacteria, prophage-related
TOL5_30130	COG0582	viral genome integration into host DNA
TOL5_30140	COG1131	(ABC) transporter
TOL5_30150	COG0842	Transport permease protein
TOL5_30180	COG0772	Belongs to the SEDS family
TOL5_30190	COG2951	lytic endotransglycosylase activity
TOL5_30290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TOL5_30300	COG0052	Belongs to the universal ribosomal protein uS2 family
TOL5_30310	COG0024	Methionine aminopeptidase
TOL5_30350	COG4172	Belongs to the ABC transporter superfamily
TOL5_30360	COG4239	(ABC) transporter, permease
TOL5_30370	COG4174	ABC transporter (Permease)
TOL5_30380	COG4166	transmembrane transport
TOL5_30390	COG0741	lytic transglycosylase activity
TOL5_30390	COG1388	LysM domain
TOL5_30400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TOL5_30500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TOL5_30510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TOL5_30520	COG0006	proline dipeptidase activity
TOL5_30590	COG1629	transport
TOL5_30600	COG1629	transport
TOL5_30690	COG1595	DNA-templated transcription, initiation
TOL5_30710	COG2832	Protein of unknown function (DUF454)
TOL5_30740	COG0745	RESPONSE REGULATOR receiver
TOL5_30750	COG2205	protein histidine kinase activity
TOL5_30770	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TOL5_30780	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TOL5_30790	COG1968	undecaprenyl-diphosphatase activity
TOL5_30800	COG1923	regulation of RNA biosynthetic process
TOL5_30830	COG2205	protein histidine kinase activity
TOL5_30840	COG2217	Heavy metal translocating P-type atpase
TOL5_30880	COG0789	Transcriptional regulator
TOL5_30910	COG0583	DNA-binding transcription factor activity
TOL5_30930	COG0583	DNA-binding transcription factor activity
TOL5_30960	COG3188	usher protein
TOL5_30990	COG4993	Dehydrogenase
TOL5_31000	COG3659	wide pore channel activity
TOL5_31010	COG3420	alginic acid biosynthetic process
TOL5_31020	COG0710	3-dehydroquinate dehydratase activity
TOL5_31030	COG3485	protocatechuate 3,4-dioxygenase
TOL5_31040	COG3485	protocatechuate 3,4-dioxygenase
TOL5_31050	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TOL5_31060	COG2271	Major facilitator Superfamily
TOL5_31070	COG0596	Alpha beta hydrolase
TOL5_31080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TOL5_31090	COG0183	Belongs to the thiolase family
TOL5_31100	COG0183	Belongs to the thiolase family
TOL5_31110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TOL5_31120	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TOL5_31130	COG1414	Transcriptional regulator
TOL5_31300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TOL5_31350	COG3712	iron ion homeostasis
TOL5_31360	COG1595	DNA-templated transcription, initiation
TOL5_31390	COG0583	DNA-binding transcription factor activity
TOL5_31440	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_31450	COG2610	gluconate transmembrane transporter activity
TOL5_31460	COG0583	DNA-binding transcription factor activity
TOL5_31480	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TOL5_31490	COG0625	glutathione transferase activity
TOL5_31500	COG0668	transmembrane transport
TOL5_31510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TOL5_31520	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TOL5_31540	COG0037	tRNA processing
TOL5_31550	COG0741	lytic transglycosylase activity
TOL5_31560	COG0501	Belongs to the peptidase M48B family
TOL5_31600	COG0418	dihydroorotase activity
TOL5_31610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TOL5_31620	COG0833	amino acid
TOL5_31630	COG0833	amino acid
TOL5_31640	COG0596	Alpha beta hydrolase
TOL5_31650	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
TOL5_31670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TOL5_31720	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TOL5_31730	COG0019	diaminopimelate decarboxylase activity
TOL5_31750	COG1113	amino acid transport
TOL5_31790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TOL5_31800	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TOL5_31810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TOL5_31840	COG2239	Acts as a magnesium transporter
TOL5_31850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TOL5_31870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TOL5_31880	COG0584	glycerophosphoryl diester phosphodiesterase
TOL5_31900	COG0459	protein refolding
TOL5_31920	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TOL5_31930	COG1597	lipid kinase activity
TOL5_31940	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TOL5_31990	COG0477	Major facilitator Superfamily
TOL5_32060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TOL5_32070	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TOL5_32080	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TOL5_32130	COG0564	pseudouridine synthase activity
TOL5_32150	COG0358	DNA primase activity
TOL5_32210	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TOL5_32220	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TOL5_32230	COG0193	aminoacyl-tRNA hydrolase activity
TOL5_32270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TOL5_32300	COG0586	Pfam SNARE associated Golgi protein
TOL5_32360	COG2921	Belongs to the UPF0250 family
TOL5_32380	COG0321	lipoyl(octanoyl) transferase activity
TOL5_32420	COG0531	amino acid
TOL5_32470	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TOL5_32480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TOL5_32480	COG1648	precorrin-2 dehydrogenase activity
TOL5_32490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TOL5_32510	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TOL5_32530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TOL5_32560	COG0671	phosphoesterase, PA-phosphatase related
TOL5_32570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOL5_32600	COG0393	Putative heavy-metal-binding
TOL5_32640	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_32660	COG0525	valine-tRNA ligase activity
TOL5_32670	COG2852	Protein conserved in bacteria
TOL5_32680	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_32720	COG0004	ammonium transporteR
TOL5_32780	COG0642	Histidine kinase
TOL5_32800	COG2194	sulfuric ester hydrolase activity
TOL5_32830	COG1752	Esterase of the alpha-beta hydrolase superfamily
TOL5_32860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TOL5_32870	COG0142	geranyltranstransferase activity
TOL5_32890	COG2828	Protein conserved in bacteria
TOL5_32900	COG1113	amino acid transport
TOL5_32960	COG4771	TonB-dependent receptor
TOL5_32990	COG1024	Enoyl-CoA hydratase
TOL5_33010	COG1309	transcriptional regulator
TOL5_33080	COG1215	transferase activity, transferring glycosyl groups
TOL5_33090	COG0726	polysaccharide deacetylase
TOL5_33090	COG1649	PFAM Uncharacterised BCR, COG1649
TOL5_33130	COG4681	YaeQ
TOL5_33140	COG0523	cobalamin synthesis protein
TOL5_33180	COG1607	acyl-coa hydrolase
TOL5_33190	COG1752	Esterase of the alpha-beta hydrolase superfamily
TOL5_33200	COG2059	Chromate
TOL5_33210	COG0786	glutamate:sodium symporter activity
TOL5_33230	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TOL5_33300	COG0420	3'-5' exonuclease activity
TOL5_33350	COG1968	undecaprenyl-diphosphatase activity
TOL5_33390	COG0735	belongs to the Fur family
TOL5_33400	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TOL5_33410	COG2914	Belongs to the UPF0125 (RnfH) family
TOL5_33430	COG2703	oxygen carrier activity
TOL5_33440	COG0121	glutamine amidotransferase
TOL5_33470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TOL5_33480	COG0756	dUTP diphosphatase activity
TOL5_33500	COG2885	chlorophyll binding
TOL5_33510	COG0204	Acyl-transferase
TOL5_33530	COG0850	regulation of cytokinetic process
TOL5_33540	COG2894	cell division
TOL5_33550	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TOL5_33610	COG1253	flavin adenine dinucleotide binding
TOL5_33620	COG2851	Citrate transporter
TOL5_33650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TOL5_33740	COG0175	sulfate reduction
TOL5_33770	COG0306	phosphate transporter
TOL5_33800	COG2852	Protein conserved in bacteria
TOL5_33820	COG2814	Major facilitator Superfamily
TOL5_33830	COG1566	PFAM secretion protein HlyD family protein
TOL5_33840	COG2050	protein possibly involved in aromatic compounds catabolism
TOL5_33860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TOL5_33880	COG0583	DNA-binding transcription factor activity
TOL5_33910	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TOL5_33930	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOL5_33940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TOL5_33950	COG0713	ATP synthesis coupled electron transport
TOL5_33970	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOL5_33980	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TOL5_34000	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TOL5_34040	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOL5_34060	COG2205	protein histidine kinase activity
TOL5_34070	COG0745	RESPONSE REGULATOR receiver
TOL5_34100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TOL5_34310	COG0037	tRNA processing
TOL5_34330	COG0248	Ppx GppA phosphatase
TOL5_34370	COG0776	regulation of translation
TOL5_34380	COG0072	phenylalanine-tRNA ligase activity
TOL5_34470	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TOL5_34510	COG1238	metal cluster binding
TOL5_34540	COG0625	glutathione transferase activity
TOL5_34630	COG0318	PFAM AMP-dependent synthetase and ligase
TOL5_34650	COG1960	acyl-CoA dehydrogenase activity
TOL5_34660	COG1960	acyl-CoA dehydrogenase activity
TOL5_34810	COG3306	glycosyltransferase involved in LPS biosynthesis
TOL5_34860	COG0438	transferase activity, transferring glycosyl groups
TOL5_34910	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TOL5_34920	COG5002	protein histidine kinase activity
TOL5_34930	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TOL5_34950	COG5383	Protein conserved in bacteria
TOL5_34960	COG1012	belongs to the aldehyde dehydrogenase family
TOL5_34970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TOL5_34980	COG0277	FAD linked oxidase domain protein
TOL5_34980	COG0247	lactate metabolic process
TOL5_34990	COG0583	DNA-binding transcription factor activity
TOL5_35000	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_35030	COG0583	DNA-binding transcription factor activity
TOL5_35080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TOL5_35140	COG1862	Preprotein translocase
TOL5_35250	COG2814	Major facilitator Superfamily
TOL5_35320	COG2814	Major facilitator Superfamily
TOL5_35340	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_35350	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_35370	COG0523	cobalamin synthesis protein
TOL5_35400	COG2188	Transcriptional regulator
TOL5_35420	COG0738	Major facilitator superfamily
TOL5_35440	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_35460	COG4948	Mandelate Racemase Muconate Lactonizing
TOL5_35480	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_35490	COG2186	Transcriptional regulator
TOL5_35510	COG3958	Transketolase
TOL5_35520	COG3959	Transketolase, thiamine diphosphate binding domain
TOL5_35530	COG2271	Major facilitator Superfamily
TOL5_35540	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_35550	COG0583	DNA-binding transcription factor activity
TOL5_35560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TOL5_35600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TOL5_35620	COG0084	hydrolase, TatD family'
TOL5_35650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TOL5_35680	COG3539	Fimbrial protein
TOL5_35700	COG3121	Chaperone
TOL5_35720	COG3539	Fimbrial protein
TOL5_35750	COG0643	Histidine kinase
TOL5_35750	COG0784	Response regulator, receiver
TOL5_35750	COG2198	Histidine kinase
TOL5_35760	COG0840	transmembrane signaling receptor activity
TOL5_35810	COG0442	prolyl-tRNA aminoacylation
TOL5_35930	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TOL5_35950	COG0489	protein tyrosine kinase activity
TOL5_36040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOL5_36040	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOL5_36070	COG2853	Lipoprotein
TOL5_36100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TOL5_36110	COG1846	Transcriptional regulator
TOL5_36120	COG1764	response to oxidative stress
TOL5_36190	COG3384	dioxygenase
TOL5_36210	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOL5_36270	COG4206	TonB-dependent receptor
TOL5_36280	COG2096	Adenosyltransferase
TOL5_36320	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TOL5_36340	COG2315	Protein conserved in bacteria
TOL5_36350	COG0745	RESPONSE REGULATOR receiver
TOL5_36360	COG2205	protein histidine kinase activity
TOL5_36380	COG3028	Belongs to the UPF0307 family
TOL5_36390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOL5_36400	COG1660	Displays ATPase and GTPase activities
TOL5_36410	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TOL5_36430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TOL5_36440	COG0617	tRNA 3'-terminal CCA addition
TOL5_36450	COG1555	photosystem II stabilization
TOL5_36460	COG3956	TIGRFAM MazG family protein
TOL5_36490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TOL5_36530	COG0784	Response regulator, receiver
TOL5_36530	COG5002	protein histidine kinase activity
TOL5_36530	COG2205	protein histidine kinase activity
TOL5_36540	COG1024	Enoyl-CoA hydratase
TOL5_36550	COG2084	Dehydrogenase
TOL5_36560	COG3622	Belongs to the hyi family
TOL5_36580	COG0004	ammonium transporteR
TOL5_36650	COG1426	Protein conserved in bacteria
TOL5_36660	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TOL5_36740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TOL5_36750	COG0440	acetolactate synthase activity
TOL5_36760	COG0028	Belongs to the TPP enzyme family
TOL5_36770	COG1309	transcriptional regulator
TOL5_36830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOL5_36840	COG0577	efflux transmembrane transporter activity
TOL5_36840	COG1136	(ABC) transporter
TOL5_36850	COG1538	Outer membrane efflux protein
TOL5_36900	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TOL5_36910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TOL5_36960	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TOL5_36970	COG1162	GTPase activity
TOL5_36990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TOL5_37060	COG3783	Cytochrome b(562)
TOL5_37070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TOL5_37080	COG2003	Belongs to the UPF0758 family
TOL5_37090	COG3781	membrane
TOL5_37160	COG1946	Acyl-CoA thioesterase
TOL5_37210	COG1295	ribonuclease BN
TOL5_37220	COG0697	spore germination
TOL5_37280	COG0179	Fumarylacetoacetate (FAA) hydrolase
TOL5_37320	COG2814	Major facilitator Superfamily
TOL5_37340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TOL5_37350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TOL5_37370	COG0765	amino acid transport
TOL5_37380	COG0765	amino acid transport
TOL5_37420	COG0557	exoribonuclease II activity
TOL5_37450	COG0339	signal peptide processing
TOL5_37460	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
TOL5_37560	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
TOL5_37570	COG1960	acyl-CoA dehydrogenase activity
TOL5_37580	COG2072	flavoprotein involved in K transport
TOL5_37590	COG0203	ribosomal protein L17
TOL5_37600	COG0202	RNA polymerase activity
TOL5_37610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TOL5_37630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TOL5_37670	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TOL5_37700	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TOL5_37740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TOL5_37800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TOL5_37830	COG0088	Forms part of the polypeptide exit tunnel
TOL5_37840	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TOL5_37850	COG0051	transcription antitermination factor activity, RNA binding
TOL5_37870	COG0626	cystathionine gamma-synthase activity
TOL5_37880	COG0433	COG0433 Predicted ATPase
TOL5_37890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TOL5_37890	COG1017	nitric oxide dioxygenase activity
TOL5_37910	COG1959	2 iron, 2 sulfur cluster binding
TOL5_37940	COG1301	dicarboxylic acid transport
TOL5_37950	COG1946	Acyl-CoA thioesterase
TOL5_37960	COG2937	Belongs to the GPAT DAPAT family
TOL5_37980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TOL5_37990	COG1040	competence protein
TOL5_38000	COG0494	nUDIX hydrolase
TOL5_38020	COG0598	Magnesium transport protein CorA
TOL5_38050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TOL5_38060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TOL5_38070	COG1127	ABC transporter
TOL5_38080	COG0513	Belongs to the DEAD box helicase family
TOL5_38110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TOL5_38120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TOL5_38130	COG0408	coproporphyrinogen oxidase activity
TOL5_38170	COG1960	acyl-CoA dehydrogenase activity
TOL5_38190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TOL5_38210	COG0534	Mate efflux family protein
TOL5_38230	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TOL5_38240	COG0254	rRNA binding
TOL5_38250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TOL5_38320	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
TOL5_38390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOL5_38420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TOL5_38440	COG0644	oxidoreductase
TOL5_38440	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
TOL5_38480	COG0425	Belongs to the sulfur carrier protein TusA family
TOL5_38490	COG4535	Mg2 and Co2 transporter CorC
TOL5_38500	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TOL5_38510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOL5_38560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TOL5_38580	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TOL5_38610	COG0789	Transcriptional regulator
TOL5_38620	COG2841	Protein conserved in bacteria
TOL5_38630	COG0598	Magnesium transport protein CorA
TOL5_38660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TOL5_38680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TOL5_38690	COG1074	ATP-dependent DNA helicase activity
TOL5_38700	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TOL5_38750	COG2226	methyltransferase
TOL5_38770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TOL5_38800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TOL5_38840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TOL5_38840	COG2111	Na H antiporter
TOL5_38850	COG1006	Multisubunit Na H antiporter MnhC subunit
TOL5_38860	COG0651	ATP synthesis coupled electron transport
TOL5_38870	COG1863	multisubunit Na H antiporter MnhE subunit
TOL5_38880	COG2212	antiporter activity
TOL5_38890	COG1320	monovalent cation:proton antiporter activity
TOL5_38900	COG0307	riboflavin synthase, alpha
TOL5_38920	COG0493	'glutamate synthase
TOL5_38930	COG0069	glutamate synthase activity
TOL5_38930	COG0070	glutamate synthase
TOL5_38930	COG0067	glutamate synthase
TOL5_39030	COG2226	methyltransferase
TOL5_39040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TOL5_39050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TOL5_39060	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TOL5_39140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TOL5_39280	COG4221	oxidoreductase activity
TOL5_39290	COG0583	DNA-binding transcription factor activity
TOL5_39310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TOL5_39310	COG3320	Male sterility
TOL5_39320	COG0789	Transcriptional regulator
TOL5_39370	COG0427	acetyl-CoA hydrolase
TOL5_39440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TOL5_39550	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TOL5_39580	COG0488	(ABC) transporter
TOL5_39600	COG2873	o-acetylhomoserine
TOL5_39610	COG0704	Plays a role in the regulation of phosphate uptake
TOL5_39660	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TOL5_39670	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TOL5_39680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TOL5_39690	COG0772	Belongs to the SEDS family
TOL5_39710	COG0586	Pfam SNARE associated Golgi protein
TOL5_39740	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOL5_39740	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOL5_39760	COG0004	ammonium transporteR
TOL5_39770	COG0347	Belongs to the P(II) protein family
TOL5_39790	COG0606	chelatase, subunit chli
TOL5_39850	COG1201	RNA secondary structure unwinding
TOL5_39960	COG4566	intracellular signal transduction
TOL5_39980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TOL5_39990	COG4569	acetaldehyde dehydrogenase (acetylating) activity
TOL5_40000	COG3971	2-oxopent-4-enoate hydratase activity
TOL5_40010	COG0346	lactoylglutathione lyase activity
TOL5_40070	COG2267	carboxylic ester hydrolase activity
TOL5_40090	COG4372	Transposase
TOL5_40140	COG2801	Transposase and inactivated derivatives
TOL5_40190	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TOL5_40350	COG0606	chelatase, subunit chli
TOL5_40460	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TOL5_40490	COG0318	PFAM AMP-dependent synthetase and ligase
TOL5_40520	COG0477	Major facilitator Superfamily
TOL5_40530	COG2860	membrane
TOL5_40550	COG1253	flavin adenine dinucleotide binding
TOL5_40650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TOL5_40670	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TOL5_40680	COG3162	membrane
TOL5_40690	COG2205	protein histidine kinase activity
TOL5_40690	COG0784	Response regulator, receiver
TOL5_40730	COG2133	pyrroloquinoline quinone binding
TOL5_40750	COG1309	transcriptional regulator
TOL5_40790	COG4771	TonB-dependent receptor
TOL5_40820	COG1652	LysM domain
TOL5_40830	COG0758	DNA mediated transformation
TOL5_40840	COG0009	L-threonylcarbamoyladenylate synthase
TOL5_40850	COG0697	spore germination
TOL5_40860	COG1309	transcriptional regulator
TOL5_40900	COG0386	Belongs to the glutathione peroxidase family
TOL5_40970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TOL5_40990	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TOL5_41030	COG0356	it plays a direct role in the translocation of protons across the membrane
TOL5_41070	COG1121	(ABC) transporter
TOL5_41080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TOL5_41100	COG1280	lysine exporter protein (LysE YggA)
TOL5_41110	COG2837	iron assimilation
TOL5_41180	COG0281	malic enzyme
TOL5_41240	COG0745	RESPONSE REGULATOR receiver
TOL5_41250	COG2205	protein histidine kinase activity
TOL5_41260	COG4452	Inner membrane protein CreD
TOL5_41310	COG2814	Major facilitator Superfamily
TOL5_41330	COG0431	NADPH-dependent FMN reductase
TOL5_41370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TOL5_41390	COG0668	transmembrane transport
TOL5_41400	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TOL5_41410	COG1519	Transferase
TOL5_41420	COG1902	pentaerythritol trinitrate reductase activity
TOL5_41460	COG1715	Restriction endonuclease
TOL5_41470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TOL5_41470	COG0519	Catalyzes the synthesis of GMP from XMP
TOL5_41490	COG2259	Doxx family
TOL5_41500	COG0586	Pfam SNARE associated Golgi protein
TOL5_41520	COG1192	Involved in chromosome partitioning
TOL5_41540	COG0271	Belongs to the BolA IbaG family
TOL5_41550	COG0235	Class ii aldolase
TOL5_41560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TOL5_41590	COG1454	alcohol dehydrogenase
TOL5_41660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TOL5_41670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TOL5_41700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TOL5_41710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TOL5_41750	COG0463	Glycosyl transferase, family 2
TOL5_41750	COG1216	Glycosyl transferase, family 2
TOL5_41790	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TOL5_41810	COG1596	polysaccharide export
TOL5_41870	COG3023	N-Acetylmuramoyl-L-alanine amidase
TOL5_41940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TOL5_41960	COG2207	Transcriptional regulator
TOL5_42000	COG1309	transcriptional regulator
TOL5_42040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TOL5_42050	COG0546	phosphoglycolate phosphatase activity
TOL5_42060	COG1028	Short-chain dehydrogenase reductase Sdr
TOL5_42120	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TOL5_42120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TOL5_42130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TOL5_42140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TOL5_42150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TOL5_42160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TOL5_42170	COG1116	anion transmembrane transporter activity
TOL5_42180	COG1309	transcriptional regulator
TOL5_42410	COG0737	Belongs to the 5'-nucleotidase family
TOL5_42420	COG2175	clavaminate synthase activity
TOL5_42430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TOL5_42440	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TOL5_42450	COG4521	taurine ABC transporter
TOL5_42490	COG0443	Heat shock 70 kDa protein
TOL5_42560	COG2951	lytic endotransglycosylase activity
TOL5_42570	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TOL5_42610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TOL5_42630	COG2388	GCN5-related N-acetyl-transferase
TOL5_42640	COG2388	GCN5-related N-acetyl-transferase
TOL5_42650	COG2814	Major facilitator Superfamily
TOL5_42660	COG1335	isochorismatase
TOL5_42670	COG0861	Integral membrane protein TerC family
TOL5_42700	COG0754	glutathionylspermidine amidase activity
TOL5_42720	COG0402	S-adenosylhomocysteine deaminase activity
TOL5_42740	COG2261	transglycosylase associated protein
TOL5_42760	COG1230	cation diffusion facilitator family transporter
TOL5_42810	COG0706	membrane insertase activity
TOL5_42820	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TOL5_42830	COG0594	ribonuclease P activity
TOL5_42860	COG0492	ferredoxin-NADP+ reductase activity
TOL5_42880	COG0589	response to stress
TOL5_42890	COG0659	secondary active sulfate transmembrane transporter activity
TOL5_42900	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
TOL5_43070	COG2233	PERMEase
TOL5_43090	COG0583	DNA-binding transcription factor activity
TOL5_43100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TOL5_43110	COG4266	Belongs to the allantoicase family
TOL5_43170	COG2233	PERMEase
TOL5_43180	COG2351	hydroxyisourate hydrolase activity
TOL5_43240	COG0582	viral genome integration into host DNA
TOL5_43250	COG2369	cell adhesion
TOL5_43290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TOL5_43340	COG4680	protein conserved in bacteria
TOL5_43360	COG2963	transposase activity
TOL5_43440	COG1309	transcriptional regulator
TOL5_43490	COG0633	Ferredoxin
TOL5_43500	COG2207	Transcriptional regulator
TOL5_43580	COG2801	Transposase and inactivated derivatives
TOL5_43600	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
TOL5_43770	COG1373	ATPase (AAA superfamily
TOL5_43880	COG1192	Involved in chromosome partitioning
TOL5_44000	COG0640	Transcriptional regulator
TOL5_44020	COG0798	PFAM Bile acid sodium symporter