locus-tag	class	description
C9E88_000020	COG1960	acyl-CoA dehydrogenase activity
C9E88_000025	COG0318	PFAM AMP-dependent synthetase and ligase
C9E88_000030	COG1250	3-hydroxyacyl-CoA dehydrogenase
C9E88_000030	COG1024	Enoyl-CoA hydratase
C9E88_000035	COG2814	Major facilitator Superfamily
C9E88_000090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C9E88_000095	COG2814	Major facilitator Superfamily
C9E88_000100	COG1566	PFAM secretion protein HlyD family protein
C9E88_000105	COG2050	protein possibly involved in aromatic compounds catabolism
C9E88_000140	COG0420	3'-5' exonuclease activity
C9E88_000165	COG0735	belongs to the Fur family
C9E88_000170	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C9E88_000175	COG2914	Belongs to the UPF0125 (RnfH) family
C9E88_000190	COG0121	glutamine amidotransferase
C9E88_000200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C9E88_000215	COG0210	DNA helicase
C9E88_000235	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C9E88_000240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C9E88_000245	COG0713	ATP synthesis coupled electron transport
C9E88_000250	COG0839	Belongs to the complex I subunit 6 family
C9E88_000255	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C9E88_000270	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C9E88_000280	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C9E88_000280	COG0649	NAD binding
C9E88_000290	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C9E88_000300	COG2205	protein histidine kinase activity
C9E88_000305	COG0745	RESPONSE REGULATOR receiver
C9E88_000310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C9E88_000310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C9E88_000315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C9E88_000325	COG4772	TonB-dependent receptor
C9E88_000355	COG0352	thiamine-phosphate diphosphorylase activity
C9E88_000355	COG0351	phosphomethylpyrimidine kinase
C9E88_000355	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C9E88_000360	COG5342	invasion associated locus B
C9E88_000365	COG0628	permease
C9E88_000380	COG3422	double-strand break repair
C9E88_000390	COG2824	Alkylphosphonate utilization operon protein PhnA
C9E88_000405	COG0564	pseudouridine synthase activity
C9E88_000455	COG0354	folic acid binding
C9E88_000510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C9E88_000515	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C9E88_000515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C9E88_000575	COG2081	HI0933 family
C9E88_000580	COG0668	transmembrane transport
C9E88_000585	COG4302	ethanolamine ammonia-lyase activity
C9E88_000590	COG4303	Ethanolamine ammonia lyase large subunit
C9E88_000595	COG0531	amino acid
C9E88_000615	COG2233	PERMEase
C9E88_000625	COG0833	amino acid
C9E88_000635	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C9E88_000635	COG2885	chlorophyll binding
C9E88_000645	COG0183	Belongs to the thiolase family
C9E88_000655	COG3384	dioxygenase
C9E88_000665	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C9E88_000675	COG2207	Transcriptional regulator
C9E88_000685	COG0183	Belongs to the thiolase family
C9E88_000690	COG1024	Enoyl-CoA hydratase
C9E88_000690	COG1250	3-hydroxyacyl-CoA dehydrogenase
C9E88_000720	COG1272	protein, Hemolysin III
C9E88_000725	COG0477	Major facilitator Superfamily
C9E88_000735	COG1408	metallophosphoesterase
C9E88_000740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C9E88_000750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C9E88_000785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C9E88_000790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C9E88_000795	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C9E88_000800	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C9E88_000805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C9E88_000820	COG0625	glutathione transferase activity
C9E88_000825	COG2969	positive regulation of protein catabolic process
C9E88_000890	COG5001	Diguanylate cyclase
C9E88_000895	COG1360	Flagellar Motor Protein
C9E88_000920	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C9E88_000925	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C9E88_000940	COG0450	alkyl hydroperoxide reductase
C9E88_000960	COG0285	dihydrofolate synthase activity
C9E88_001010	COG0133	tryptophan synthase activity
C9E88_001025	COG4206	TonB-dependent receptor
C9E88_001030	COG2096	Adenosyltransferase
C9E88_001060	COG1113	amino acid transport
C9E88_001065	COG0745	RESPONSE REGULATOR receiver
C9E88_001070	COG2205	protein histidine kinase activity
C9E88_001080	COG1960	acyl-CoA dehydrogenase activity
C9E88_001085	COG1960	acyl-CoA dehydrogenase activity
C9E88_001105	COG3223	Belongs to the PsiE family
C9E88_001135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C9E88_001165	COG0438	transferase activity, transferring glycosyl groups
C9E88_001170	COG0463	Glycosyl transferase, family 2
C9E88_001175	COG0726	polysaccharide deacetylase
C9E88_001195	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C9E88_001220	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C9E88_001230	COG1704	LemA family
C9E88_001245	COG1862	Preprotein translocase
C9E88_001265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C9E88_001285	COG2205	protein histidine kinase activity
C9E88_001285	COG0784	Response regulator, receiver
C9E88_001285	COG5002	protein histidine kinase activity
C9E88_001290	COG1024	Enoyl-CoA hydratase
C9E88_001295	COG2084	Dehydrogenase
C9E88_001300	COG3622	Belongs to the hyi family
C9E88_001315	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C9E88_001320	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C9E88_001325	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C9E88_001330	COG0697	spore germination
C9E88_001345	COG2814	Major facilitator Superfamily
C9E88_001370	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C9E88_001385	COG0732	type I restriction modification DNA specificity domain
C9E88_001395	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C9E88_001415	COG0174	glutamine synthetase
C9E88_001420	COG0745	RESPONSE REGULATOR receiver
C9E88_001425	COG2205	protein histidine kinase activity
C9E88_001435	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C9E88_001440	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C9E88_001445	COG1968	undecaprenyl-diphosphatase activity
C9E88_001505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C9E88_001510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C9E88_001515	COG2003	Belongs to the UPF0758 family
C9E88_001520	COG3781	membrane
C9E88_001535	COG2350	Protein conserved in bacteria
C9E88_001570	COG1607	acyl-coa hydrolase
C9E88_001585	COG3453	Protein conserved in bacteria
C9E88_001585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C9E88_001635	COG1183	phosphatidylcholine synthase activity
C9E88_001640	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C9E88_001675	COG0739	heme binding
C9E88_001675	COG0741	lytic transglycosylase activity
C9E88_001675	COG1196	nuclear chromosome segregation
C9E88_001680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C9E88_001685	COG1702	phosphate starvation-inducible protein PhoH
C9E88_001725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C9E88_001745	COG1295	ribonuclease BN
C9E88_001755	COG0697	spore germination
C9E88_001765	COG0179	Fumarylacetoacetate (FAA) hydrolase
C9E88_001800	COG0557	exoribonuclease II activity
C9E88_001815	COG0339	signal peptide processing
C9E88_001820	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C9E88_001830	COG0697	spore germination
C9E88_001855	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C9E88_001860	COG1960	acyl-CoA dehydrogenase activity
C9E88_001870	COG2072	flavoprotein involved in K transport
C9E88_001875	COG0203	ribosomal protein L17
C9E88_001890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C9E88_001900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C9E88_001920	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C9E88_001930	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C9E88_001935	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C9E88_001955	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C9E88_001970	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C9E88_001985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C9E88_002000	COG0088	Forms part of the polypeptide exit tunnel
C9E88_002005	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C9E88_002010	COG0051	transcription antitermination factor activity, RNA binding
C9E88_002025	COG0433	COG0433 Predicted ATPase
C9E88_002030	COG1017	nitric oxide dioxygenase activity
C9E88_002030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C9E88_002035	COG1959	2 iron, 2 sulfur cluster binding
C9E88_002050	COG1301	dicarboxylic acid transport
C9E88_002055	COG1946	Acyl-CoA thioesterase
C9E88_002060	COG2937	Belongs to the GPAT DAPAT family
C9E88_002075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C9E88_002080	COG1040	competence protein
C9E88_002085	COG0494	nUDIX hydrolase
C9E88_002095	COG0598	Magnesium transport protein CorA
C9E88_002115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C9E88_002120	COG1127	ABC transporter
C9E88_002130	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C9E88_002145	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C9E88_002155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C9E88_002175	COG1960	acyl-CoA dehydrogenase activity
C9E88_002180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C9E88_002190	COG0534	Mate efflux family protein
C9E88_002200	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C9E88_002205	COG0254	rRNA binding
C9E88_002210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C9E88_002230	COG2226	methyltransferase
C9E88_002245	COG1192	Involved in chromosome partitioning
C9E88_002250	COG0628	permease
C9E88_002265	COG1289	transmembrane transporter activity
C9E88_002270	COG2814	Major facilitator Superfamily
C9E88_002295	COG0277	FAD linked oxidase domain protein
C9E88_002300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C9E88_002305	COG5006	permease, DMT superfamily
C9E88_002330	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C9E88_002335	COG5380	lipid catabolic process
C9E88_002340	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C9E88_002345	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C9E88_002360	COG0335	large ribosomal subunit rRNA binding
C9E88_002370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C9E88_002375	COG0228	four-way junction DNA binding
C9E88_002420	COG0194	GDP metabolic process
C9E88_002425	COG1758	RNA polymerase activity
C9E88_002430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C9E88_002455	COG0438	transferase activity, transferring glycosyl groups
C9E88_002470	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C9E88_002470	COG0463	Glycosyl transferase, family 2
C9E88_002495	COG1132	(ABC) transporter
C9E88_002520	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C9E88_002525	COG1704	LemA family
C9E88_002535	COG0493	'glutamate synthase
C9E88_002540	COG0069	glutamate synthase activity
C9E88_002540	COG0067	glutamate synthase
C9E88_002540	COG0070	glutamate synthase
C9E88_002590	COG2226	methyltransferase
C9E88_002595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C9E88_002600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C9E88_002605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C9E88_002625	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C9E88_002630	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C9E88_002640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C9E88_002660	COG0488	(ABC) transporter
C9E88_002670	COG4221	oxidoreductase activity
C9E88_002675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C9E88_002690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C9E88_002690	COG2111	Na H antiporter
C9E88_002695	COG1006	Multisubunit Na H antiporter MnhC subunit
C9E88_002700	COG0651	ATP synthesis coupled electron transport
C9E88_002710	COG2212	antiporter activity
C9E88_002720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C9E88_002730	COG0195	Participates in both transcription termination and antitermination
C9E88_002785	COG0237	dephospho-CoA kinase activity
C9E88_002795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C9E88_002800	COG3123	guanosine phosphorylase activity
C9E88_002805	COG0497	DNA recombination
C9E88_002815	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C9E88_002830	COG1289	transmembrane transporter activity
C9E88_002845	COG0704	Plays a role in the regulation of phosphate uptake
C9E88_002860	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C9E88_002865	COG0494	nUDIX hydrolase
C9E88_002870	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C9E88_002875	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C9E88_002880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C9E88_002885	COG0772	Belongs to the SEDS family
C9E88_002910	COG4974	Belongs to the 'phage' integrase family
C9E88_002915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C9E88_002925	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C9E88_002930	COG1686	Belongs to the peptidase S11 family
C9E88_002935	COG2197	response regulator
C9E88_002950	COG0793	Belongs to the peptidase S41A family
C9E88_002955	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C9E88_002960	COG0795	lipopolysaccharide-transporting ATPase activity
C9E88_002965	COG0795	lipopolysaccharide-transporting ATPase activity
C9E88_002990	COG0586	Pfam SNARE associated Golgi protein
C9E88_003005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C9E88_003005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C9E88_003015	COG0004	ammonium transporteR
C9E88_003020	COG0347	Belongs to the P(II) protein family
C9E88_003030	COG0606	chelatase, subunit chli
C9E88_003050	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C9E88_003065	COG0318	PFAM AMP-dependent synthetase and ligase
C9E88_003075	COG0477	Major facilitator Superfamily
C9E88_003080	COG2860	membrane
C9E88_003090	COG1253	flavin adenine dinucleotide binding
C9E88_003105	COG2814	Major facilitator Superfamily
C9E88_003115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C9E88_003135	COG4783	chaperone-mediated protein folding
C9E88_003165	COG1309	transcriptional regulator
C9E88_003200	COG0758	DNA mediated transformation
C9E88_003220	COG0386	Belongs to the glutathione peroxidase family
C9E88_003265	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C9E88_003275	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C9E88_003315	COG1121	(ABC) transporter
C9E88_003320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C9E88_003325	COG2318	DinB family
C9E88_003340	COG2837	iron assimilation
C9E88_003375	COG3501	Rhs element vgr protein
C9E88_003380	COG0436	Aminotransferase
C9E88_003385	COG0534	Mate efflux family protein
C9E88_003400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C9E88_003405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C9E88_003470	COG3706	GGDEF domain
C9E88_003485	COG1401	restriction endodeoxyribonuclease activity
C9E88_003490	COG0519	Catalyzes the synthesis of GMP from XMP
C9E88_003490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C9E88_003500	COG2259	Doxx family
C9E88_003505	COG0586	Pfam SNARE associated Golgi protein
C9E88_003520	COG1192	Involved in chromosome partitioning
C9E88_003585	COG2801	Transposase and inactivated derivatives
C9E88_003595	COG2801	Transposase and inactivated derivatives
C9E88_003610	COG1454	alcohol dehydrogenase
C9E88_003655	COG3550	peptidyl-serine autophosphorylation
C9E88_003660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C9E88_003675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9E88_003675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9E88_003675	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C9E88_003680	COG1105	Belongs to the carbohydrate kinase PfkB family
C9E88_003685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C9E88_003685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C9E88_003695	COG4716	Myosin-crossreactive antigen
C9E88_003735	COG1309	transcriptional regulator
C9E88_003750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C9E88_003755	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C9E88_003760	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C9E88_003765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C9E88_003770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C9E88_003775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C9E88_003780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C9E88_003790	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C9E88_003795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C9E88_003805	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C9E88_003805	COG0662	Cupin 2, conserved barrel domain protein
C9E88_003810	COG0297	glycogen (starch) synthase activity
C9E88_003815	COG0110	maltose O-acetyltransferase activity
C9E88_003845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C9E88_003855	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C9E88_003865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C9E88_003875	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C9E88_003880	COG0438	transferase activity, transferring glycosyl groups
C9E88_003885	COG0438	transferase activity, transferring glycosyl groups
C9E88_003890	COG0438	transferase activity, transferring glycosyl groups
C9E88_003900	COG0110	maltose O-acetyltransferase activity
C9E88_003915	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C9E88_003955	COG1194	a g-specific adenine glycosylase
C9E88_003960	COG0739	heme binding
C9E88_003970	COG2818	Glycosylase
C9E88_003975	COG1064	alcohol dehydrogenase
C9E88_003995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C9E88_004000	COG3307	-O-antigen
C9E88_004020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9E88_004025	COG1309	transcriptional regulator
C9E88_004100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C9E88_004155	COG0733	neurotransmitter:sodium symporter activity
C9E88_004185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C9E88_004250	COG0488	(ABC) transporter
C9E88_004260	COG0187	DNA topoisomerase II activity
C9E88_004270	COG0592	DNA-directed DNA polymerase activity
C9E88_004275	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C9E88_004280	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C9E88_004290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C9E88_004295	COG0706	membrane insertase activity
C9E88_004330	COG0402	S-adenosylhomocysteine deaminase activity
C9E88_004335	COG0861	Integral membrane protein TerC family
C9E88_004340	COG2814	Major facilitator Superfamily
C9E88_004365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C9E88_004380	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C9E88_004385	COG2951	lytic endotransglycosylase activity
C9E88_004390	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C9E88_004395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C9E88_004435	COG2814	Major facilitator Superfamily
C9E88_004440	COG2814	Major facilitator Superfamily
C9E88_004470	COG1047	Peptidyl-prolyl cis-trans
C9E88_004480	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C9E88_004485	COG0196	riboflavin kinase activity
C9E88_004505	COG1309	transcriptional regulator
C9E88_004510	COG1116	anion transmembrane transporter activity
C9E88_004515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C9E88_004520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C9E88_004525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C9E88_004550	COG1028	Short-chain dehydrogenase reductase Sdr
C9E88_004555	COG0546	phosphoglycolate phosphatase activity
C9E88_004560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C9E88_004575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C9E88_004590	COG3023	N-Acetylmuramoyl-L-alanine amidase
C9E88_004595	COG0728	peptidoglycan biosynthetic process
C9E88_004600	COG5487	UPF0391 membrane protein
C9E88_004605	COG2983	Belongs to the UPF0260 family
C9E88_004615	COG3300	MHYT domain
C9E88_004615	COG5001	Diguanylate cyclase
C9E88_004620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C9E88_004635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C9E88_004640	COG2814	Major facilitator Superfamily
C9E88_004650	COG1335	isochorismatase
C9E88_004655	COG0385	Bile acid
C9E88_004665	COG0560	Phosphoserine phosphatase
C9E88_004665	COG3830	Belongs to the UPF0237 family
C9E88_004695	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C9E88_004725	COG2733	membrane
C9E88_004740	COG2918	glutathione biosynthetic process
C9E88_004745	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C9E88_004755	COG3150	esterase
C9E88_004770	COG0559	Belongs to the binding-protein-dependent transport system permease family
C9E88_004785	COG0410	ABC transporter
C9E88_004795	COG1247	-acetyltransferase
C9E88_004835	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C9E88_004855	COG0708	Exodeoxyribonuclease III
C9E88_004860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C9E88_004870	COG1278	Cold shock
C9E88_004875	COG0189	ligase activity
C9E88_004885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C9E88_004890	COG1181	Belongs to the D-alanine--D-alanine ligase family
C9E88_004895	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C9E88_004905	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C9E88_004935	COG2119	membrane
C9E88_004965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C9E88_004990	COG1902	pentaerythritol trinitrate reductase activity
C9E88_004995	COG1519	Transferase
C9E88_005000	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C9E88_005005	COG0668	transmembrane transport
C9E88_005015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C9E88_005025	COG0307	riboflavin synthase, alpha
C9E88_005040	COG0431	NADPH-dependent FMN reductase
C9E88_005055	COG0784	Response regulator, receiver
C9E88_005055	COG2205	protein histidine kinase activity
C9E88_005060	COG3162	membrane
C9E88_005085	COG0745	RESPONSE REGULATOR receiver
C9E88_005085	COG3706	GGDEF domain
C9E88_005115	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C9E88_005125	COG2814	Major facilitator Superfamily
C9E88_005130	COG0629	single-stranded DNA binding
C9E88_005140	COG1309	transcriptional regulator
C9E88_005145	COG0450	alkyl hydroperoxide reductase
C9E88_005155	COG1335	isochorismatase
C9E88_005190	COG3158	transport of potassium into the cell
C9E88_005235	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C9E88_005255	COG0531	amino acid
C9E88_005265	COG0697	spore germination
C9E88_005285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C9E88_005385	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C9E88_005400	COG3275	phosphorelay sensor kinase activity
C9E88_005410	COG0181	hydroxymethylbilane synthase activity
C9E88_005460	COG0546	phosphoglycolate phosphatase activity
C9E88_005515	COG0081	regulation of translation
C9E88_005520	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C9E88_005530	COG0085	RNA polymerase activity
C9E88_005560	COG2056	Na+-H+ antiporter family
C9E88_005565	COG3047	cAMP biosynthetic process
C9E88_005575	COG0326	Molecular chaperone. Has ATPase activity
C9E88_005600	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C9E88_005610	COG0427	acetyl-CoA hydrolase
C9E88_005615	COG2205	protein histidine kinase activity
C9E88_005620	COG0745	RESPONSE REGULATOR receiver
C9E88_005650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C9E88_005680	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C9E88_005685	COG1074	ATP-dependent DNA helicase activity
C9E88_005690	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C9E88_005700	COG1185	polyribonucleotide nucleotidyltransferase activity
C9E88_005705	COG0598	Magnesium transport protein CorA
C9E88_005715	COG2841	Protein conserved in bacteria
C9E88_005720	COG0789	Transcriptional regulator
C9E88_005745	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C9E88_005755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C9E88_005780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C9E88_005780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C9E88_005785	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C9E88_005790	COG4535	Mg2 and Co2 transporter CorC
C9E88_005795	COG0425	Belongs to the sulfur carrier protein TusA family
C9E88_005800	COG3501	Rhs element vgr protein
C9E88_005815	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C9E88_005815	COG0644	oxidoreductase
C9E88_005825	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C9E88_005840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C9E88_005850	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C9E88_005860	COG0493	'glutamate synthase
C9E88_005885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C9E88_005950	COG1983	PspC domain protein
C9E88_005985	COG1530	ribonuclease E activity
C9E88_005995	COG0564	pseudouridine synthase activity
C9E88_006005	COG3971	2-oxopent-4-enoate hydratase activity
C9E88_006010	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C9E88_006030	COG0583	DNA-binding transcription factor activity
C9E88_006035	COG4638	Rieske (2fe-2S)
C9E88_006050	COG1028	Short-chain dehydrogenase reductase Sdr
C9E88_006055	COG3384	dioxygenase
C9E88_006060	COG0446	pyridine nucleotide-disulphide oxidoreductase
C9E88_006090	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C9E88_006105	COG1960	acyl-CoA dehydrogenase activity
C9E88_006110	COG1522	sequence-specific DNA binding
C9E88_006165	COG0583	DNA-binding transcription factor activity
C9E88_006175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C9E88_006190	COG0473	3-isopropylmalate dehydrogenase activity
C9E88_006255	COG1560	Kdo2-lipid A biosynthetic process
C9E88_006315	COG1929	Belongs to the glycerate kinase type-1 family
C9E88_006330	COG0210	DNA helicase
C9E88_006335	COG0724	RNA recognition motif
C9E88_006360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C9E88_006360	COG4651	solute:proton antiporter activity
C9E88_006365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C9E88_006370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C9E88_006385	COG0788	formyltetrahydrofolate deformylase activity
C9E88_006470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C9E88_006500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C9E88_006500	COG2813	Specifically methylates the guanine in position
C9E88_006510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C9E88_006520	COG3128	pkhd-type hydroxylase
C9E88_006525	COG4774	siderophore transport
C9E88_006530	COG4774	siderophore transport
C9E88_006535	COG4774	siderophore transport
C9E88_006545	COG0740	serine-type endopeptidase activity
C9E88_006565	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C9E88_006565	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C9E88_006590	COG0857	belongs to the CobB CobQ family
C9E88_006590	COG0280	phosphate acetyltransferase
C9E88_006595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C9E88_006620	COG0793	Belongs to the peptidase S41A family
C9E88_006645	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C9E88_006660	COG0084	hydrolase, TatD family'
C9E88_006675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C9E88_006685	COG1162	GTPase activity
C9E88_006690	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C9E88_006700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C9E88_006705	COG3501	Rhs element vgr protein
C9E88_006740	COG0577	efflux transmembrane transporter activity
C9E88_006740	COG1136	(ABC) transporter
C9E88_006745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9E88_006770	COG0028	Belongs to the TPP enzyme family
C9E88_006775	COG0440	acetolactate synthase activity
C9E88_006805	COG4585	Histidine kinase
C9E88_006840	COG1426	Protein conserved in bacteria
C9E88_006860	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C9E88_006875	COG0300	oxidoreductase activity
C9E88_006880	COG3956	TIGRFAM MazG family protein
C9E88_006885	COG1596	polysaccharide export
C9E88_006885	COG1555	photosystem II stabilization
C9E88_006890	COG0617	tRNA 3'-terminal CCA addition
C9E88_006895	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C9E88_006910	COG1660	Displays ATPase and GTPase activities
C9E88_006925	COG0318	PFAM AMP-dependent synthetase and ligase
C9E88_006965	COG0625	glutathione transferase activity
C9E88_006975	COG1238	metal cluster binding
C9E88_006995	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C9E88_007030	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C9E88_007035	COG0072	phenylalanine-tRNA ligase activity
C9E88_007060	COG0248	Ppx GppA phosphatase
C9E88_007070	COG0037	tRNA processing
C9E88_007115	COG1764	response to oxidative stress
C9E88_007125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C9E88_007195	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C9E88_007200	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C9E88_007210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C9E88_007250	COG0494	nUDIX hydrolase
C9E88_007260	COG1214	PFAM Peptidase M22, glycoprotease
C9E88_007265	COG1968	undecaprenyl-diphosphatase activity
C9E88_007280	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C9E88_007290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C9E88_007300	COG2132	Multicopper oxidase
C9E88_007315	COG2076	Multidrug Resistance protein
C9E88_007320	COG2076	Multidrug Resistance protein
C9E88_007335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C9E88_007370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C9E88_007390	COG0730	response to heat
C9E88_007410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C9E88_007415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C9E88_007420	COG2801	Transposase and inactivated derivatives
C9E88_007430	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C9E88_007435	COG2193	ferroxidase activity
C9E88_007440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C9E88_007450	COG2267	carboxylic ester hydrolase activity
C9E88_007465	COG4106	trans-aconitate 2-methyltransferase activity
C9E88_007480	COG1187	pseudouridine synthase activity
C9E88_007485	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C9E88_007490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C9E88_007500	COG0009	L-threonylcarbamoyladenylate synthase
C9E88_007505	COG3101	peptidyl-lysine hydroxylation
C9E88_007510	COG1399	metal-binding, possibly nucleic acid-binding protein
C9E88_007515	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C9E88_007525	COG1028	Short-chain dehydrogenase reductase Sdr
C9E88_007535	COG1652	LysM domain
C9E88_007555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C9E88_007580	COG0456	acetyltransferase
C9E88_007590	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C9E88_007595	COG0492	ferredoxin-NADP+ reductase activity
C9E88_007600	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C9E88_007600	COG1674	ftsk spoiiie
C9E88_007635	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C9E88_007640	COG2894	cell division
C9E88_007655	COG0204	Acyl-transferase
C9E88_007660	COG2885	chlorophyll binding
C9E88_007665	COG0583	DNA-binding transcription factor activity
C9E88_007685	COG0489	protein tyrosine kinase activity
C9E88_007720	COG0442	prolyl-tRNA aminoacylation
C9E88_007730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9E88_007755	COG0840	transmembrane signaling receptor activity
C9E88_007785	COG2832	Protein of unknown function (DUF454)
C9E88_007845	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C9E88_007855	COG1289	transmembrane transporter activity
C9E88_007860	COG2814	Major facilitator Superfamily
C9E88_007875	COG0786	glutamate:sodium symporter activity
C9E88_007880	COG1115	amino acid carrier protein
C9E88_007885	COG1752	Esterase of the alpha-beta hydrolase superfamily
C9E88_007895	COG1607	acyl-coa hydrolase
C9E88_007900	COG1309	transcriptional regulator
C9E88_007905	COG2814	Major facilitator Superfamily
C9E88_007910	COG0583	DNA-binding transcription factor activity
C9E88_007925	COG0523	cobalamin synthesis protein
C9E88_007930	COG4681	YaeQ
C9E88_007945	COG2203	Gaf domain
C9E88_007945	COG2199	diguanylate cyclase activity
C9E88_007980	COG0477	Major facilitator Superfamily
C9E88_008000	COG0242	peptide deformylase activity
C9E88_008010	COG2223	nitrite transmembrane transporter activity
C9E88_008020	COG0210	DNA helicase
C9E88_008025	COG2376	Dihydroxyacetone kinase
C9E88_008030	COG3706	GGDEF domain
C9E88_008035	COG2852	Protein conserved in bacteria
C9E88_008055	COG0306	phosphate transporter
C9E88_008085	COG4771	TonB-dependent receptor
C9E88_008110	COG4181	ATPase activity
C9E88_008115	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C9E88_008135	COG2197	response regulator
C9E88_008140	COG0583	DNA-binding transcription factor activity
C9E88_008150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C9E88_008155	COG1773	rubredoxin
C9E88_008160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C9E88_008185	COG2354	Protein conserved in bacteria
C9E88_008190	COG2321	neutral zinc metallopeptidase
C9E88_008250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C9E88_008250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C9E88_008260	COG0714	Associated with various cellular activities
C9E88_008275	COG1028	Short-chain dehydrogenase reductase Sdr
C9E88_008280	COG2072	flavoprotein involved in K transport
C9E88_008290	COG2009	succinate dehydrogenase
C9E88_008295	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C9E88_008300	COG1053	succinate dehydrogenase
C9E88_008305	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C9E88_008320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C9E88_008330	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C9E88_008335	COG2268	Band 7 protein
C9E88_008350	COG0175	sulfate reduction
C9E88_008375	COG1695	Transcriptional regulator
C9E88_008415	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C9E88_008430	COG0477	Major facilitator Superfamily
C9E88_008445	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C9E88_008450	COG1597	lipid kinase activity
C9E88_008455	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C9E88_008495	COG4774	siderophore transport
C9E88_008500	COG3015	lipoprotein NlpE involved in copper resistance
C9E88_008505	COG0204	Acyl-transferase
C9E88_008525	COG0742	ribosomal rna small subunit methyltransferase
C9E88_008530	COG0768	penicillin binding
C9E88_008555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C9E88_008560	COG2878	Part of a membrane complex involved in electron transport
C9E88_008565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C9E88_008575	COG3384	dioxygenase
C9E88_008585	COG2234	aminopeptidase activity
C9E88_008595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C9E88_008610	COG1944	ATP diphosphatase activity
C9E88_008640	COG0006	proline dipeptidase activity
C9E88_008650	COG0789	Transcriptional regulator
C9E88_008655	COG1309	transcriptional regulator
C9E88_008665	COG0596	Alpha beta hydrolase
C9E88_008670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C9E88_008675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C9E88_008735	COG0741	lytic transglycosylase activity
C9E88_008735	COG1388	LysM domain
C9E88_008745	COG4174	ABC transporter (Permease)
C9E88_008750	COG4239	(ABC) transporter, permease
C9E88_008755	COG4172	Belongs to the ABC transporter superfamily
C9E88_008790	COG0833	amino acid
C9E88_008800	COG0833	amino acid
C9E88_008825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C9E88_008830	COG0418	dihydroorotase activity
C9E88_008835	COG3706	GGDEF domain
C9E88_008850	COG0446	pyridine nucleotide-disulphide oxidoreductase
C9E88_008850	COG1902	pentaerythritol trinitrate reductase activity
C9E88_008905	COG2184	nucleotidyltransferase activity
C9E88_008915	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C9E88_008985	COG1741	Belongs to the pirin family
C9E88_009000	COG3739	integral membrane protein
C9E88_009025	COG0302	gtp cyclohydrolase
C9E88_009045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C9E88_009050	COG0512	Glutamine amidotransferase of anthranilate synthase
C9E88_009060	COG0662	Cupin 2, conserved barrel domain protein
C9E88_009060	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C9E88_009100	COG0438	transferase activity, transferring glycosyl groups
C9E88_009130	COG3161	chorismate lyase activity
C9E88_009135	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C9E88_009145	COG0583	DNA-binding transcription factor activity
C9E88_009200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C9E88_009205	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C9E88_009210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C9E88_009220	COG0596	Alpha beta hydrolase
C9E88_009225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C9E88_009230	COG1335	isochorismatase
C9E88_009235	COG0251	oxidation-reduction process
C9E88_009240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C9E88_009245	COG2233	PERMEase
C9E88_009265	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C9E88_009280	COG2175	clavaminate synthase activity
C9E88_009300	COG3706	GGDEF domain
C9E88_009310	COG0556	nucleotide-excision repair
C9E88_009350	COG0702	epimerase
C9E88_009355	COG1733	regulation of RNA biosynthetic process
C9E88_009360	COG2814	Major facilitator Superfamily
C9E88_009370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C9E88_009375	COG0671	phosphoesterase, PA-phosphatase related
C9E88_009385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C9E88_009390	COG0076	glutamate decarboxylase activity
C9E88_009400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C9E88_009405	COG0573	inorganic phosphate transmembrane transporter activity
C9E88_009415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C9E88_009430	COG0616	signal peptide processing
C9E88_009465	COG2915	High frequency lysogenization protein hflD homolog
C9E88_009470	COG0482	sulfurtransferase activity
C9E88_009480	COG1396	sequence-specific DNA binding
C9E88_009485	COG0697	spore germination
C9E88_009495	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C9E88_009500	COG1686	Belongs to the peptidase S11 family
C9E88_009525	COG0583	DNA-binding transcription factor activity
C9E88_009530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C9E88_009535	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C9E88_009540	COG1067	ATP-dependent peptidase activity
C9E88_009580	COG1509	lysine 2,3-aminomutase activity
C9E88_009585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C9E88_009590	COG1966	Carbon starvation protein
C9E88_009595	COG2879	small protein
C9E88_009600	COG0714	Associated with various cellular activities
C9E88_009720	COG1765	OsmC-like protein
C9E88_009730	COG0667	Aldo Keto reductase
C9E88_009785	COG0540	Belongs to the ATCase OTCase family
C9E88_009825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C9E88_009840	COG0659	secondary active sulfate transmembrane transporter activity
C9E88_009845	COG0625	glutathione transferase activity
C9E88_009865	COG2363	Small membrane protein
C9E88_009890	COG0513	Belongs to the DEAD box helicase family
C9E88_009900	COG0778	Nitroreductase
C9E88_009925	COG0167	dihydroorotate dehydrogenase activity
C9E88_009955	COG4783	chaperone-mediated protein folding
C9E88_009970	COG1610	YqeY-like protein
C9E88_009975	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C9E88_009980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C9E88_009985	COG0387	Pfam Sodium calcium exchanger
C9E88_010005	COG2815	serine threonine protein kinase
C9E88_010005	COG0515	serine threonine protein kinase
C9E88_010070	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C9E88_010070	COG2755	lipolytic protein G-D-S-L family
C9E88_010075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C9E88_010085	COG0612	Peptidase, M16
C9E88_010115	COG0352	thiamine-phosphate diphosphorylase activity
C9E88_010175	COG4566	intracellular signal transduction
C9E88_010180	COG1309	transcriptional regulator
C9E88_010205	COG1649	PFAM Uncharacterised BCR, COG1649
C9E88_010205	COG0726	polysaccharide deacetylase
C9E88_010210	COG1215	transferase activity, transferring glycosyl groups
C9E88_010225	COG2070	2-Nitropropane dioxygenase
C9E88_010245	COG2391	methyltransferase activity
C9E88_010265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C9E88_010270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C9E88_010295	COG1280	lysine exporter protein (LysE YggA)
C9E88_010300	COG0519	Catalyzes the synthesis of GMP from XMP
C9E88_010300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C9E88_010330	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C9E88_010340	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C9E88_010345	COG1137	ATPase activity
C9E88_010355	COG2274	protein secretion by the type I secretion system
C9E88_010370	COG0110	maltose O-acetyltransferase activity
C9E88_010375	COG0589	response to stress
C9E88_010390	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C9E88_010400	COG3706	GGDEF domain
C9E88_010440	COG2011	ABC-type metal ion transport system permease component
C9E88_010445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C9E88_010450	COG1464	Belongs to the NlpA lipoprotein family
C9E88_010480	COG0138	bifunctional purine biosynthesis protein purh
C9E88_010485	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C9E88_010530	COG2814	Major facilitator Superfamily
C9E88_010545	COG3852	Histidine kinase
C9E88_010565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C9E88_010570	COG0575	Belongs to the CDS family
C9E88_010585	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C9E88_010605	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C9E88_010620	COG2137	regulation of response to DNA damage stimulus
C9E88_010630	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C9E88_010635	COG1011	Hydrolase
C9E88_010640	COG1218	3'(2'),5'-bisphosphate nucleotidase
C9E88_010660	COG0702	epimerase
C9E88_010665	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C9E88_010675	COG2197	response regulator
C9E88_010685	COG2850	peptidyl-arginine hydroxylation
C9E88_010700	COG0424	maF-like protein
C9E88_010710	COG0126	phosphoglycerate kinase activity
C9E88_010725	COG0697	spore germination
C9E88_010775	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C9E88_010785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C9E88_010790	COG3781	membrane
C9E88_010795	COG0210	DNA helicase
C9E88_010835	COG1027	Aspartate ammonia-lyase
C9E88_010845	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C9E88_010875	COG0316	Belongs to the HesB IscA family
C9E88_010880	COG0822	iron-sulfur transferase activity
C9E88_010910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C9E88_010940	COG1585	Membrane protein implicated in regulation of membrane protease activity
C9E88_010950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C9E88_010975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C9E88_010980	COG0569	domain protein
C9E88_010995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C9E88_011000	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C9E88_011025	COG0463	Glycosyl transferase, family 2
C9E88_011035	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C9E88_011045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C9E88_011050	COG0542	response to heat
C9E88_011080	COG0372	Belongs to the citrate synthase family
C9E88_011085	COG1546	Belongs to the CinA family
C9E88_011085	COG1058	Belongs to the CinA family
C9E88_011105	COG1960	acyl-CoA dehydrogenase activity
C9E88_011110	COG1960	acyl-CoA dehydrogenase activity
C9E88_011175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C9E88_011180	COG0730	response to heat
C9E88_011190	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C9E88_011200	COG2207	Transcriptional regulator
C9E88_011205	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C9E88_011240	COG2814	Major facilitator Superfamily
C9E88_011255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C9E88_011270	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C9E88_011310	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C9E88_011360	COG1114	Component of the transport system for branched-chain amino acids
C9E88_011365	COG0024	Methionine aminopeptidase
C9E88_011370	COG0583	DNA-binding transcription factor activity
C9E88_011375	COG2267	carboxylic ester hydrolase activity
C9E88_011385	COG0446	pyridine nucleotide-disulphide oxidoreductase
C9E88_011385	COG1902	pentaerythritol trinitrate reductase activity
C9E88_011400	COG2814	Major facilitator Superfamily
C9E88_011410	COG0583	DNA-binding transcription factor activity
C9E88_011430	COG0148	phosphopyruvate hydratase activity
C9E88_011445	COG0772	Belongs to the SEDS family
C9E88_011465	COG4890	Cyd operon protein YbgT
C9E88_011470	COG1294	oxidase, subunit
C9E88_011490	COG0537	adenosine 5'-monophosphoramidase activity
C9E88_011520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C9E88_011545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C9E88_011555	COG0133	tryptophan synthase activity
C9E88_011565	COG0517	IMP dehydrogenase activity
C9E88_011595	COG0612	Peptidase, M16
C9E88_011600	COG0552	protein localization to endoplasmic reticulum
C9E88_011615	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C9E88_011645	COG3706	GGDEF domain
C9E88_011660	COG2814	Major facilitator Superfamily
C9E88_011665	COG2199	diguanylate cyclase activity
C9E88_011675	COG0439	Biotin carboxylase
C9E88_011725	COG0596	Alpha beta hydrolase
C9E88_011810	COG2885	chlorophyll binding
C9E88_011820	COG2801	Transposase and inactivated derivatives
C9E88_011835	COG3550	peptidyl-serine autophosphorylation
C9E88_011860	COG4628	conserved protein (DUF2132)
C9E88_011895	COG1028	Short-chain dehydrogenase reductase Sdr
C9E88_011955	COG1960	acyl-CoA dehydrogenase activity
C9E88_011970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C9E88_011970	COG1648	precorrin-2 dehydrogenase activity
C9E88_011975	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C9E88_011980	COG4149	molybdate abc transporter
C9E88_011985	COG0725	ABC transporter, periplasmic molybdate-binding protein
C9E88_011990	COG0303	'Molybdopterin
C9E88_011995	COG0315	cyclic pyranopterin monophosphate synthase activity
C9E88_011995	COG0521	Mo-molybdopterin cofactor biosynthetic process
C9E88_012010	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C9E88_012020	COG0243	molybdopterin cofactor binding
C9E88_012025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C9E88_012030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C9E88_012035	COG2223	nitrite transmembrane transporter activity
C9E88_012045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C9E88_012045	COG1116	anion transmembrane transporter activity
C9E88_012050	COG0583	DNA-binding transcription factor activity
C9E88_012055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C9E88_012060	COG4266	Belongs to the allantoicase family
C9E88_012070	COG2233	PERMEase
C9E88_012075	COG2351	hydroxyisourate hydrolase activity
C9E88_012090	COG0583	DNA-binding transcription factor activity
C9E88_012095	COG1380	Effector of murein hydrolase LrgA
C9E88_012100	COG1346	cytolysis
C9E88_012105	COG0697	spore germination
C9E88_012110	COG0281	malic enzyme
C9E88_012150	COG0318	PFAM AMP-dependent synthetase and ligase
C9E88_012160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C9E88_012170	COG2814	Major facilitator Superfamily
C9E88_012175	COG0583	DNA-binding transcription factor activity
C9E88_012180	COG4948	Mandelate Racemase Muconate Lactonizing
C9E88_012185	COG4829	muconolactone delta-isomerase
C9E88_012195	COG4638	Rieske (2fe-2S)
C9E88_012200	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C9E88_012205	COG0633	Ferredoxin
C9E88_012205	COG0543	2 iron, 2 sulfur cluster binding
C9E88_012210	COG1028	Short-chain dehydrogenase reductase Sdr
C9E88_012215	COG3135	benzoate transporter
C9E88_012220	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C9E88_012225	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C9E88_012230	COG0183	Belongs to the thiolase family
C9E88_012235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C9E88_012240	COG0402	S-adenosylhomocysteine deaminase activity
C9E88_012295	COG2814	Major facilitator Superfamily
C9E88_012310	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C9E88_012340	COG0730	response to heat
C9E88_012345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C9E88_012350	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C9E88_012365	COG1959	2 iron, 2 sulfur cluster binding
C9E88_012380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C9E88_012390	COG0864	Transcriptional regulator
C9E88_012400	COG0778	Nitroreductase
C9E88_012410	COG1733	regulation of RNA biosynthetic process
C9E88_012445	COG0439	Biotin carboxylase
C9E88_012460	COG2175	clavaminate synthase activity
C9E88_012465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C9E88_012470	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C9E88_012475	COG4521	taurine ABC transporter
C9E88_012500	COG0427	acetyl-CoA hydrolase
C9E88_012505	COG0183	Belongs to the thiolase family
C9E88_012510	COG1960	acyl-CoA dehydrogenase activity
C9E88_012525	COG0789	Transcriptional regulator
C9E88_012535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C9E88_012540	COG0640	Transcriptional regulator
C9E88_012560	COG3122	Protein conserved in bacteria
C9E88_012570	COG1132	(ABC) transporter
C9E88_012595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C9E88_012610	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C9E88_012615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C9E88_012635	COG0697	spore germination
C9E88_012680	COG1960	acyl-CoA dehydrogenase activity
C9E88_012685	COG0583	DNA-binding transcription factor activity
C9E88_012690	COG1525	nuclease
C9E88_012700	COG2814	Major facilitator Superfamily
C9E88_012750	COG3038	cytochrome b561
C9E88_012865	COG4387	Mu-like prophage protein GP36
C9E88_012900	COG5410	chromosome segregation
C9E88_012925	COG1278	Cold shock
C9E88_013030	COG4197	protein conserved in bacteria, prophage-related
C9E88_013035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C9E88_013080	COG0582	viral genome integration into host DNA
C9E88_013130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C9E88_013155	COG1570	exodeoxyribonuclease VII activity
C9E88_013180	COG0729	surface antigen
C9E88_013185	COG0477	Major facilitator Superfamily
C9E88_013205	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C9E88_013215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C9E88_013220	COG1309	transcriptional regulator
C9E88_013225	COG2814	Major facilitator Superfamily
C9E88_013230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C9E88_013235	COG1960	acyl-CoA dehydrogenase activity
C9E88_013255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C9E88_013260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C9E88_013265	COG2890	protein-(glutamine-N5) methyltransferase activity
C9E88_013270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C9E88_013290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C9E88_013315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C9E88_013320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C9E88_013325	COG1845	cytochrome c oxidase, subunit III
C9E88_013330	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C9E88_013350	COG0360	Binds together with S18 to 16S ribosomal RNA
C9E88_013365	COG0305	Participates in initiation and elongation during chromosome replication
C9E88_013370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C9E88_013385	COG1305	Transglutaminase-like
C9E88_013395	COG2308	Evidence 4 Homologs of previously reported genes of
C9E88_013405	COG0069	glutamate synthase activity
C9E88_013425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C9E88_013430	COG1454	alcohol dehydrogenase
C9E88_013440	COG0824	Thioesterase
C9E88_013445	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C9E88_013475	COG0183	Belongs to the thiolase family
C9E88_013485	COG0583	DNA-binding transcription factor activity
C9E88_013490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C9E88_013500	COG1309	transcriptional regulator
C9E88_013515	COG0589	response to stress
C9E88_013520	COG0589	response to stress
C9E88_013535	COG0308	aminopeptidase N
C9E88_013565	COG1253	flavin adenine dinucleotide binding
C9E88_013595	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C9E88_013600	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C9E88_013615	COG2431	L-lysine efflux transmembrane transporter activity
C9E88_013635	COG0776	regulation of translation
C9E88_013655	COG0590	tRNA wobble adenosine to inosine editing
C9E88_013665	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C9E88_013685	COG2165	general secretion pathway protein
C9E88_013700	COG0084	hydrolase, TatD family'
C9E88_013720	COG1663	tetraacyldisaccharide 4'-kinase activity
C9E88_013725	COG1132	(ABC) transporter
C9E88_013735	COG0811	peptide transport
C9E88_013740	COG1475	DNA binding
C9E88_013745	COG1192	Involved in chromosome partitioning
C9E88_013755	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C9E88_013770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C9E88_013775	COG1923	regulation of RNA biosynthetic process
C9E88_013780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C9E88_013785	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C9E88_013790	COG0802	atpase or kinase
C9E88_013795	COG0564	pseudouridine synthase activity
C9E88_013815	COG2707	UPF0756 membrane protein
C9E88_013830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C9E88_013850	COG1643	Atp-dependent helicase
C9E88_013855	COG0450	alkyl hydroperoxide reductase
C9E88_013875	COG3634	alkyl hydroperoxide reductase activity
C9E88_013905	COG1254	Belongs to the acylphosphatase family
C9E88_013910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C9E88_013910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C9E88_013940	COG0415	Belongs to the DNA photolyase family
C9E88_013985	COG0204	Acyl-transferase
C9E88_014035	COG2011	ABC-type metal ion transport system permease component
C9E88_014040	COG0012	GTP binding
C9E88_014070	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C9E88_014105	COG0386	Belongs to the glutathione peroxidase family
C9E88_014115	COG0436	Aminotransferase
C9E88_014120	COG1187	pseudouridine synthase activity
C9E88_014135	COG1686	Belongs to the peptidase S11 family
C9E88_014140	COG1252	NADH dehydrogenase
C9E88_014160	COG4783	chaperone-mediated protein folding
C9E88_014165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C9E88_014180	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C9E88_014195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C9E88_014200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C9E88_014205	COG0527	aspartate kinase activity
C9E88_014215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C9E88_014250	COG2252	PERMEase
C9E88_014275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C9E88_014280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C9E88_014290	COG0693	protein deglycase activity
C9E88_014300	COG1301	dicarboxylic acid transport
C9E88_014305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C9E88_014310	COG3139	Protein of unknown function (DUF1315)
C9E88_014315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C9E88_014320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C9E88_014330	COG0494	nUDIX hydrolase
C9E88_014345	COG0745	RESPONSE REGULATOR receiver
C9E88_014355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C9E88_014365	COG1720	tRNA m6t6A37 methyltransferase activity
C9E88_014405	COG3501	Rhs element vgr protein
C9E88_014415	COG0789	Transcriptional regulator
C9E88_014420	COG0431	NADPH-dependent FMN reductase
C9E88_014425	COG0798	PFAM Bile acid sodium symporter
C9E88_014430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C9E88_014435	COG0640	Transcriptional regulator
C9E88_014445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C9E88_014450	COG3634	alkyl hydroperoxide reductase activity
C9E88_014475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C9E88_014510	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C9E88_014515	COG3177	Filamentation induced by cAMP protein fic
C9E88_014525	COG0431	NADPH-dependent FMN reductase
C9E88_014530	COG0798	PFAM Bile acid sodium symporter
C9E88_014540	COG0640	Transcriptional regulator
C9E88_014570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C9E88_014595	COG0640	Transcriptional regulator
C9E88_014600	COG1136	(ABC) transporter
C9E88_014610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9E88_014615	COG3177	Filamentation induced by cAMP protein fic
C9E88_014655	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C9E88_014685	COG3177	Filamentation induced by cAMP protein fic
C9E88_014745	COG0582	viral genome integration into host DNA
C9E88_014755	COG1131	(ABC) transporter
C9E88_014760	COG0842	Transport permease protein
C9E88_014780	COG2951	lytic endotransglycosylase activity
C9E88_014820	COG0052	Belongs to the universal ribosomal protein uS2 family
C9E88_014825	COG0024	Methionine aminopeptidase
C9E88_014860	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C9E88_014875	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C9E88_014880	COG0571	ribonuclease III activity
C9E88_014890	COG0681	Belongs to the peptidase S26 family
C9E88_014905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C9E88_014935	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C9E88_014940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C9E88_014945	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C9E88_014950	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C9E88_014965	COG4208	sulfate ABC transporter
C9E88_014970	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C9E88_014975	COG0583	DNA-binding transcription factor activity
C9E88_014995	COG0602	queuosine metabolic process
C9E88_015000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C9E88_015010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C9E88_015020	COG0583	DNA-binding transcription factor activity
C9E88_015025	COG2353	YceI-like domain
C9E88_015030	COG1056	cytidyltransferase-related domain
C9E88_015030	COG1051	belongs to the nudix hydrolase family
C9E88_015040	COG0778	Nitroreductase
C9E88_015045	COG3323	Protein of unknown function (DUF1653)
C9E88_015045	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C9E88_015070	COG0047	phosphoribosylformylglycinamidine synthase activity
C9E88_015070	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C9E88_015100	COG2255	four-way junction helicase activity
C9E88_015110	COG0824	Thioesterase
C9E88_015130	COG0823	Involved in the tonB-independent uptake of proteins
C9E88_015135	COG2885	chlorophyll binding
C9E88_015150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C9E88_015185	COG0628	permease
C9E88_015190	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C9E88_015195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C9E88_015215	COG2333	competence protein COMEC
C9E88_015215	COG0658	competence protein
C9E88_015220	COG1136	(ABC) transporter
C9E88_015225	COG4591	ABC-type transport system involved in lipoprotein release permease component
C9E88_015240	COG1671	Belongs to the UPF0178 family
C9E88_015260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9E88_015275	COG1301	dicarboxylic acid transport
C9E88_015305	COG1280	lysine exporter protein (LysE YggA)
C9E88_015310	COG1522	sequence-specific DNA binding
C9E88_015320	COG0154	amidase activity
C9E88_015325	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C9E88_015340	COG0019	diaminopimelate decarboxylase activity
C9E88_015370	COG1196	nuclear chromosome segregation
C9E88_015370	COG0741	lytic transglycosylase activity
C9E88_015370	COG0739	heme binding
C9E88_015385	COG1196	nuclear chromosome segregation
C9E88_015385	COG0741	lytic transglycosylase activity
C9E88_015385	COG0739	heme binding
C9E88_015450	COG1192	Involved in chromosome partitioning
C9E88_015520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C9E88_015550	COG2826	transposase and inactivated derivatives, IS30 family
C9E88_015570	COG0673	inositol 2-dehydrogenase activity
C9E88_015575	COG1324	tolerance protein
C9E88_015605	COG2826	transposase and inactivated derivatives, IS30 family
C9E88_015625	COG1525	nuclease
C9E88_015640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C9E88_015650	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C9E88_015675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C9E88_015685	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C9E88_015705	COG0564	pseudouridine synthase activity
C9E88_015715	COG0358	DNA primase activity
C9E88_015730	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C9E88_015760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C9E88_015765	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C9E88_015790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C9E88_015820	COG0586	Pfam SNARE associated Golgi protein
C9E88_015850	COG0321	lipoyl(octanoyl) transferase activity
C9E88_015865	COG0531	amino acid
C9E88_015875	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C9E88_015880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C9E88_015880	COG1648	precorrin-2 dehydrogenase activity
C9E88_015885	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C9E88_015895	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C9E88_015900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C9E88_015905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C9E88_015920	COG0671	phosphoesterase, PA-phosphatase related
C9E88_015925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9E88_015930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C9E88_015935	COG1538	Outer membrane efflux protein
C9E88_015940	COG0393	Putative heavy-metal-binding
C9E88_015945	COG0393	Putative heavy-metal-binding
C9E88_015955	COG1028	Short-chain dehydrogenase reductase Sdr
C9E88_015965	COG0525	valine-tRNA ligase activity
C9E88_015990	COG3706	GGDEF domain
C9E88_015995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C9E88_016000	COG0765	amino acid transport
C9E88_016005	COG0765	amino acid transport
C9E88_016010	COG1126	abc transporter atp-binding protein
C9E88_016015	COG0004	ammonium transporteR
C9E88_016030	COG0642	Histidine kinase
C9E88_016035	COG0745	RESPONSE REGULATOR receiver
C9E88_016040	COG2194	sulfuric ester hydrolase activity
C9E88_016055	COG1752	Esterase of the alpha-beta hydrolase superfamily
C9E88_016070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C9E88_016075	COG0142	geranyltranstransferase activity
C9E88_016080	COG2828	Protein conserved in bacteria
C9E88_016085	COG1113	amino acid transport
C9E88_016110	COG0560	Phosphoserine phosphatase
C9E88_016120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C9E88_016125	COG1530	ribonuclease E activity
C9E88_016130	COG0424	maF-like protein
C9E88_016135	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C9E88_016140	COG1792	Involved in formation and maintenance of cell shape
C9E88_016145	COG1077	Cell shape determining protein MreB Mrl
C9E88_016150	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C9E88_016160	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C9E88_016190	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C9E88_016230	COG1115	amino acid carrier protein
C9E88_016250	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C9E88_016265	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C9E88_016270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C9E88_016275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C9E88_016280	COG5001	Diguanylate cyclase
C9E88_016280	COG1716	ATPase activity
C9E88_016285	COG0280	phosphate acetyltransferase
C9E88_016285	COG0281	malic enzyme
C9E88_016300	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C9E88_016330	COG0583	DNA-binding transcription factor activity
C9E88_016340	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C9E88_016350	COG0037	tRNA processing
C9E88_016355	COG0739	heme binding
C9E88_016355	COG0741	lytic transglycosylase activity
C9E88_016355	COG1196	nuclear chromosome segregation
C9E88_016360	COG0501	Belongs to the peptidase M48B family
C9E88_016370	COG2239	Acts as a magnesium transporter
C9E88_016405	COG1253	flavin adenine dinucleotide binding
C9E88_016415	COG2851	Citrate transporter
C9E88_016445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C9E88_016450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C9E88_016475	COG0505	Belongs to the CarA family
C9E88_016500	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C9E88_016520	COG3173	Aminoglycoside phosphotransferase
C9E88_016565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C9E88_016595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C9E88_016610	COG1192	Involved in chromosome partitioning
C9E88_016615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C9E88_016630	COG1106	Psort location Cytoplasmic, score
C9E88_016665	COG2801	Transposase and inactivated derivatives