locus-tag	class	description
M5E07_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M5E07_00020	COG0187	DNA topoisomerase II activity
M5E07_00030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M5E07_00035	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M5E07_00060	COG0488	(ABC) transporter
M5E07_00090	COG2814	Major facilitator Superfamily
M5E07_00095	COG2133	pyrroloquinoline quinone binding
M5E07_00110	COG2233	PERMEase
M5E07_00125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E07_00150	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M5E07_00160	COG2814	Major facilitator Superfamily
M5E07_00165	COG0656	L-ascorbic acid biosynthetic process
M5E07_00170	COG0583	DNA-binding transcription factor activity
M5E07_00180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E07_00185	COG1064	alcohol dehydrogenase
M5E07_00190	COG2818	Glycosylase
M5E07_00205	COG1194	a g-specific adenine glycosylase
M5E07_00220	COG5487	UPF0391 membrane protein
M5E07_00225	COG2983	Belongs to the UPF0260 family
M5E07_00230	COG2819	hydrolase of the alpha beta superfamily
M5E07_00235	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M5E07_00245	COG4160	amino acid transport
M5E07_00250	COG4215	(ABC) transporter
M5E07_00265	COG1522	sequence-specific DNA binding
M5E07_00270	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M5E07_00280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M5E07_00285	COG2814	Major facilitator Superfamily
M5E07_00290	COG1335	isochorismatase
M5E07_00295	COG0385	Bile acid
M5E07_00310	COG0560	Phosphoserine phosphatase
M5E07_00310	COG3830	Belongs to the UPF0237 family
M5E07_00365	COG0534	Mate efflux family protein
M5E07_00370	COG0436	Aminotransferase
M5E07_00375	COG2733	membrane
M5E07_00390	COG2918	glutathione biosynthetic process
M5E07_00395	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M5E07_00405	COG3150	esterase
M5E07_00480	COG3706	GGDEF domain
M5E07_00485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M5E07_00505	COG0708	Exodeoxyribonuclease III
M5E07_00510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M5E07_00545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M5E07_00555	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M5E07_00565	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M5E07_00590	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E07_00600	COG2119	membrane
M5E07_00605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M5E07_00605	COG0426	domain, Protein
M5E07_00615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5E07_00625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M5E07_00650	COG1902	pentaerythritol trinitrate reductase activity
M5E07_00655	COG1519	Transferase
M5E07_00660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M5E07_00665	COG0668	transmembrane transport
M5E07_00675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5E07_00690	COG0431	NADPH-dependent FMN reductase
M5E07_00705	COG2198	Histidine kinase
M5E07_00705	COG2205	protein histidine kinase activity
M5E07_00705	COG0784	Response regulator, receiver
M5E07_00710	COG3162	membrane
M5E07_00725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M5E07_00740	COG3706	GGDEF domain
M5E07_00755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M5E07_00760	COG1309	transcriptional regulator
M5E07_00780	COG0300	oxidoreductase activity
M5E07_00785	COG0789	Transcriptional regulator
M5E07_00790	COG0351	phosphomethylpyrimidine kinase
M5E07_00790	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M5E07_00790	COG0352	thiamine-phosphate diphosphorylase activity
M5E07_00800	COG2814	Major facilitator Superfamily
M5E07_00805	COG0629	single-stranded DNA binding
M5E07_00810	COG1113	amino acid transport
M5E07_00820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M5E07_00825	COG1012	belongs to the aldehyde dehydrogenase family
M5E07_00840	COG1335	isochorismatase
M5E07_00850	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
M5E07_00870	COG2814	Major facilitator Superfamily
M5E07_00875	COG0583	DNA-binding transcription factor activity
M5E07_00900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5E07_00905	COG1960	acyl-CoA dehydrogenase activity
M5E07_00910	COG1024	Enoyl-CoA hydratase
M5E07_00950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M5E07_00970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M5E07_00990	COG0531	amino acid
M5E07_00995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M5E07_01015	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M5E07_01020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M5E07_01055	COG0427	acetyl-CoA hydrolase
M5E07_01085	COG4221	oxidoreductase activity
M5E07_01090	COG2873	o-acetylhomoserine
M5E07_01095	COG0488	(ABC) transporter
M5E07_01160	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M5E07_01180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M5E07_01185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M5E07_01195	COG2226	methyltransferase
M5E07_01245	COG0067	glutamate synthase
M5E07_01245	COG0069	glutamate synthase activity
M5E07_01245	COG0070	glutamate synthase
M5E07_01250	COG0493	'glutamate synthase
M5E07_01260	COG1704	LemA family
M5E07_01265	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M5E07_01275	COG4969	Belongs to the N-Me-Phe pilin family
M5E07_01280	COG4969	Belongs to the N-Me-Phe pilin family
M5E07_01290	COG3307	-O-antigen
M5E07_01310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M5E07_01315	COG1758	RNA polymerase activity
M5E07_01320	COG0194	GDP metabolic process
M5E07_01365	COG0228	four-way junction DNA binding
M5E07_01370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M5E07_01380	COG0335	large ribosomal subunit rRNA binding
M5E07_01385	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M5E07_01390	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M5E07_01395	COG5380	lipid catabolic process
M5E07_01400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M5E07_01420	COG5006	permease, DMT superfamily
M5E07_01425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M5E07_01430	COG0277	FAD linked oxidase domain protein
M5E07_01455	COG2814	Major facilitator Superfamily
M5E07_01465	COG2032	superoxide dismutase activity
M5E07_01470	COG0628	permease
M5E07_01475	COG1192	Involved in chromosome partitioning
M5E07_01500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M5E07_01510	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M5E07_01515	COG0534	Mate efflux family protein
M5E07_01525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M5E07_01535	COG1960	acyl-CoA dehydrogenase activity
M5E07_01555	COG0408	coproporphyrinogen oxidase activity
M5E07_01560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M5E07_01570	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M5E07_01580	COG0513	Belongs to the DEAD box helicase family
M5E07_01585	COG1127	ABC transporter
M5E07_01590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M5E07_01595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M5E07_01610	COG0598	Magnesium transport protein CorA
M5E07_01620	COG2816	NAD+ diphosphatase activity
M5E07_01625	COG1040	competence protein
M5E07_01630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M5E07_01675	COG2937	Belongs to the GPAT DAPAT family
M5E07_01680	COG1946	Acyl-CoA thioesterase
M5E07_01690	COG1301	dicarboxylic acid transport
M5E07_01710	COG1959	2 iron, 2 sulfur cluster binding
M5E07_01720	COG0433	COG0433 Predicted ATPase
M5E07_01725	COG0626	cystathionine gamma-synthase activity
M5E07_01745	COG0088	Forms part of the polypeptide exit tunnel
M5E07_01750	COG0089	rRNA binding
M5E07_01760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M5E07_01810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M5E07_01815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M5E07_01825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M5E07_01850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M5E07_01860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M5E07_01865	COG0202	RNA polymerase activity
M5E07_01870	COG0203	ribosomal protein L17
M5E07_01875	COG2072	flavoprotein involved in K transport
M5E07_01880	COG1960	acyl-CoA dehydrogenase activity
M5E07_01885	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M5E07_01915	COG0697	spore germination
M5E07_01930	COG0339	signal peptide processing
M5E07_01940	COG0557	exoribonuclease II activity
M5E07_01975	COG0179	Fumarylacetoacetate (FAA) hydrolase
M5E07_02005	COG1295	ribonuclease BN
M5E07_02045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M5E07_02050	COG1702	phosphate starvation-inducible protein PhoH
M5E07_02055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M5E07_02060	COG1196	nuclear chromosome segregation
M5E07_02060	COG0741	lytic transglycosylase activity
M5E07_02060	COG0739	heme binding
M5E07_02095	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M5E07_02100	COG1183	phosphatidylcholine synthase activity
M5E07_02140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E07_02170	COG1607	acyl-coa hydrolase
M5E07_02180	COG1666	GTP binding
M5E07_02200	COG2350	Protein conserved in bacteria
M5E07_02215	COG0625	glutathione transferase activity
M5E07_02220	COG3781	membrane
M5E07_02225	COG2003	Belongs to the UPF0758 family
M5E07_02230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M5E07_02235	COG3783	Cytochrome b(562)
M5E07_02265	COG1162	GTPase activity
M5E07_02270	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M5E07_02285	COG1538	Outer membrane efflux protein
M5E07_02290	COG0577	efflux transmembrane transporter activity
M5E07_02290	COG1136	(ABC) transporter
M5E07_02295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E07_02320	COG0028	Belongs to the TPP enzyme family
M5E07_02325	COG0440	acetolactate synthase activity
M5E07_02430	COG1862	Preprotein translocase
M5E07_02440	COG4251	negative regulation of phosphorylation
M5E07_02440	COG5001	Diguanylate cyclase
M5E07_02440	COG2203	Gaf domain
M5E07_02440	COG3706	GGDEF domain
M5E07_02445	COG1704	LemA family
M5E07_02455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M5E07_02525	COG1113	amino acid transport
M5E07_02535	COG0625	glutathione transferase activity
M5E07_02555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E07_02560	COG1522	sequence-specific DNA binding
M5E07_02565	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M5E07_02580	COG0084	hydrolase, TatD family'
M5E07_02595	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M5E07_02605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5E07_02630	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M5E07_02640	COG1335	isochorismatase
M5E07_02650	COG0640	Transcriptional regulator
M5E07_02660	COG0798	PFAM Bile acid sodium symporter
M5E07_02665	COG0431	NADPH-dependent FMN reductase
M5E07_02680	COG2814	Major facilitator Superfamily
M5E07_02690	COG0789	Transcriptional regulator
M5E07_02695	COG0697	spore germination
M5E07_02720	COG0004	ammonium transporteR
M5E07_02735	COG3622	Belongs to the hyi family
M5E07_02740	COG2084	Dehydrogenase
M5E07_02745	COG1024	Enoyl-CoA hydratase
M5E07_02750	COG5002	protein histidine kinase activity
M5E07_02750	COG0784	Response regulator, receiver
M5E07_02750	COG2205	protein histidine kinase activity
M5E07_02755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5E07_02770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M5E07_02775	COG3956	TIGRFAM MazG family protein
M5E07_02780	COG1555	photosystem II stabilization
M5E07_02790	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M5E07_02805	COG1660	Displays ATPase and GTPase activities
M5E07_02815	COG3028	Belongs to the UPF0307 family
M5E07_02820	COG0318	PFAM AMP-dependent synthetase and ligase
M5E07_02830	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M5E07_02840	COG0625	glutathione transferase activity
M5E07_02850	COG1238	metal cluster binding
M5E07_02890	COG0072	phenylalanine-tRNA ligase activity
M5E07_02915	COG0248	Ppx GppA phosphatase
M5E07_02925	COG0037	tRNA processing
M5E07_02970	COG1764	response to oxidative stress
M5E07_02975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M5E07_03040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M5E07_03050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M5E07_03110	COG1214	PFAM Peptidase M22, glycoprotease
M5E07_03115	COG1968	undecaprenyl-diphosphatase activity
M5E07_03195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M5E07_03205	COG2132	Multicopper oxidase
M5E07_03235	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M5E07_03235	COG0352	thiamine-phosphate diphosphorylase activity
M5E07_03235	COG0351	phosphomethylpyrimidine kinase
M5E07_03265	COG0251	oxidation-reduction process
M5E07_03270	COG1113	amino acid transport
M5E07_03280	COG1981	membrane
M5E07_03295	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M5E07_03305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M5E07_03310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M5E07_03320	COG0456	acetyltransferase
M5E07_03330	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M5E07_03335	COG0492	ferredoxin-NADP+ reductase activity
M5E07_03340	COG1674	ftsk spoiiie
M5E07_03345	COG0583	DNA-binding transcription factor activity
M5E07_03360	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M5E07_03365	COG2894	cell division
M5E07_03370	COG0850	regulation of cytokinetic process
M5E07_03380	COG0204	Acyl-transferase
M5E07_03385	COG2885	chlorophyll binding
M5E07_03390	COG0210	DNA helicase
M5E07_03395	COG0756	dUTP diphosphatase activity
M5E07_03400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5E07_03405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M5E07_03415	COG0121	glutamine amidotransferase
M5E07_03430	COG2914	Belongs to the UPF0125 (RnfH) family
M5E07_03435	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M5E07_03440	COG0735	belongs to the Fur family
M5E07_03450	COG0420	3'-5' exonuclease activity
M5E07_03465	COG1090	epimerase
M5E07_03480	COG2050	protein possibly involved in aromatic compounds catabolism
M5E07_03490	COG2814	Major facilitator Superfamily
M5E07_03495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M5E07_03505	COG0582	viral genome integration into host DNA
M5E07_03595	COG3046	protein related to deoxyribodipyrimidine photolyase
M5E07_03600	COG2816	NAD+ diphosphatase activity
M5E07_03640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M5E07_03655	COG0642	Histidine kinase
M5E07_03660	COG0745	RESPONSE REGULATOR receiver
M5E07_03690	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5E07_03700	COG0583	DNA-binding transcription factor activity
M5E07_03710	COG3209	COG3209 Rhs family protein
M5E07_03730	COG1414	Transcriptional regulator
M5E07_03735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M5E07_03745	COG2814	Major facilitator Superfamily
M5E07_03750	COG1012	belongs to the aldehyde dehydrogenase family
M5E07_03750	COG2030	dehydratase
M5E07_03755	COG3396	Phenylacetate-CoA oxygenase
M5E07_03760	COG3460	Phenylacetate-CoA oxygenase
M5E07_03765	COG3396	Phenylacetate-CoA oxygenase
M5E07_03770	COG2151	metal-sulfur cluster biosynthetic enzyme
M5E07_03775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5E07_03780	COG1024	Enoyl-CoA hydratase
M5E07_03785	COG1024	Enoyl-CoA hydratase
M5E07_03790	COG1250	3-hydroxyacyl-CoA dehydrogenase
M5E07_03795	COG0183	Belongs to the thiolase family
M5E07_03800	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M5E07_03805	COG3327	negative regulation of DNA-templated transcription, initiation
M5E07_03825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E07_03825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E07_03850	COG0489	protein tyrosine kinase activity
M5E07_03890	COG0442	prolyl-tRNA aminoacylation
M5E07_03900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E07_03925	COG0840	transmembrane signaling receptor activity
M5E07_03940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5E07_03955	COG2832	Protein of unknown function (DUF454)
M5E07_04015	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M5E07_04025	COG1289	transmembrane transporter activity
M5E07_04030	COG2814	Major facilitator Superfamily
M5E07_04050	COG0589	response to stress
M5E07_04060	COG0110	maltose O-acetyltransferase activity
M5E07_04070	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M5E07_04075	COG0505	Belongs to the CarA family
M5E07_04100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M5E07_04105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M5E07_04110	COG2304	oxidoreductase activity
M5E07_04160	COG0477	Major facilitator Superfamily
M5E07_04180	COG1597	lipid kinase activity
M5E07_04210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5E07_04225	COG0741	lytic transglycosylase activity
M5E07_04230	COG0037	tRNA processing
M5E07_04240	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M5E07_04245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M5E07_04265	COG0583	DNA-binding transcription factor activity
M5E07_04300	COG1012	belongs to the aldehyde dehydrogenase family
M5E07_04330	COG0006	proline dipeptidase activity
M5E07_04335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M5E07_04340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M5E07_04360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M5E07_04365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M5E07_04395	COG2816	NAD+ diphosphatase activity
M5E07_04405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M5E07_04410	COG1388	LysM domain
M5E07_04410	COG0741	lytic transglycosylase activity
M5E07_04415	COG4166	transmembrane transport
M5E07_04420	COG4174	ABC transporter (Permease)
M5E07_04425	COG4239	(ABC) transporter, permease
M5E07_04430	COG4172	Belongs to the ABC transporter superfamily
M5E07_04510	COG0833	amino acid
M5E07_04530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M5E07_04535	COG0418	dihydroorotase activity
M5E07_04550	COG2186	Transcriptional regulator
M5E07_04560	COG0277	FAD linked oxidase domain protein
M5E07_04565	COG1902	pentaerythritol trinitrate reductase activity
M5E07_04565	COG0446	pyridine nucleotide-disulphide oxidoreductase
M5E07_04595	COG1358	cellular component organization or biogenesis
M5E07_04635	COG2304	oxidoreductase activity
M5E07_04660	COG0242	peptide deformylase activity
M5E07_04670	COG2223	nitrite transmembrane transporter activity
M5E07_04685	COG2852	Protein conserved in bacteria
M5E07_04705	COG0306	phosphate transporter
M5E07_04715	COG1215	transferase activity, transferring glycosyl groups
M5E07_04720	COG0726	polysaccharide deacetylase
M5E07_04720	COG1649	PFAM Uncharacterised BCR, COG1649
M5E07_04725	COG0583	DNA-binding transcription factor activity
M5E07_04735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5E07_04740	COG1773	rubredoxin
M5E07_04745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M5E07_04770	COG1741	Belongs to the pirin family
M5E07_04780	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M5E07_04785	COG3739	integral membrane protein
M5E07_04815	COG0302	gtp cyclohydrolase
M5E07_04830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M5E07_04835	COG0512	Glutamine amidotransferase of anthranilate synthase
M5E07_04840	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M5E07_04845	COG2249	NAD(P)H dehydrogenase (quinone) activity
M5E07_04860	COG0523	cobalamin synthesis protein
M5E07_04865	COG4681	YaeQ
M5E07_04875	COG2199	diguanylate cyclase activity
M5E07_04875	COG2203	Gaf domain
M5E07_04940	COG0288	reversible hydration of carbon dioxide
M5E07_04950	COG4181	ATPase activity
M5E07_04955	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M5E07_04975	COG2197	response regulator
M5E07_05005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M5E07_05010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M5E07_05020	COG0604	alcohol dehydrogenase
M5E07_05020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E07_05020	COG4221	oxidoreductase activity
M5E07_05020	COG3321	synthase
M5E07_05030	COG2851	Citrate transporter
M5E07_05035	COG1253	flavin adenine dinucleotide binding
M5E07_05070	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M5E07_05080	COG0281	malic enzyme
M5E07_05080	COG0280	phosphate acetyltransferase
M5E07_05090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M5E07_05095	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M5E07_05100	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M5E07_05130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M5E07_05135	COG0778	Nitroreductase
M5E07_05140	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M5E07_05145	COG1051	belongs to the nudix hydrolase family
M5E07_05145	COG1056	cytidyltransferase-related domain
M5E07_05150	COG2353	YceI-like domain
M5E07_05155	COG0583	DNA-binding transcription factor activity
M5E07_05160	COG1279	arginine transmembrane transporter activity
M5E07_05165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M5E07_05180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M5E07_05185	COG0602	queuosine metabolic process
M5E07_05205	COG0583	DNA-binding transcription factor activity
M5E07_05210	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M5E07_05215	COG4208	sulfate ABC transporter
M5E07_05230	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M5E07_05235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5E07_05240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M5E07_05260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5E07_05270	COG0481	GTPase activity
M5E07_05275	COG0681	Belongs to the peptidase S26 family
M5E07_05285	COG0571	ribonuclease III activity
M5E07_05290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M5E07_05305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M5E07_05345	COG0436	Aminotransferase
M5E07_05365	COG0556	nucleotide-excision repair
M5E07_05405	COG1733	regulation of RNA biosynthetic process
M5E07_05420	COG0671	phosphoesterase, PA-phosphatase related
M5E07_05430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M5E07_05435	COG0076	glutamate decarboxylase activity
M5E07_05440	COG1522	sequence-specific DNA binding
M5E07_05445	COG3961	Belongs to the TPP enzyme family
M5E07_05450	COG1113	amino acid transport
M5E07_05455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M5E07_05460	COG0573	inorganic phosphate transmembrane transporter activity
M5E07_05470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5E07_05475	COG0616	signal peptide processing
M5E07_05520	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M5E07_05525	COG1686	Belongs to the peptidase S11 family
M5E07_05540	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M5E07_05550	COG0583	DNA-binding transcription factor activity
M5E07_05555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M5E07_05560	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M5E07_05585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5E07_05590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5E07_05600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M5E07_05615	COG2986	histidine ammonia-lyase
M5E07_05655	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_05660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M5E07_05675	COG2070	2-Nitropropane dioxygenase
M5E07_05710	COG1067	ATP-dependent peptidase activity
M5E07_05745	COG1509	lysine 2,3-aminomutase activity
M5E07_05750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M5E07_05755	COG1966	Carbon starvation protein
M5E07_05760	COG2879	small protein
M5E07_05765	COG0714	Associated with various cellular activities
M5E07_05840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M5E07_05920	COG4695	Portal protein
M5E07_06050	COG3549	Plasmid maintenance system killer
M5E07_06055	COG3093	addiction module antidote protein HigA
M5E07_06100	COG2252	PERMEase
M5E07_06105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M5E07_06110	COG3038	cytochrome b561
M5E07_06125	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M5E07_06135	COG0527	aspartate kinase activity
M5E07_06145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5E07_06165	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M5E07_06180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M5E07_06195	COG0667	Aldo Keto reductase
M5E07_06205	COG1765	OsmC-like protein
M5E07_06210	COG0542	response to heat
M5E07_06230	COG1301	dicarboxylic acid transport
M5E07_06235	COG0116	Belongs to the methyltransferase superfamily
M5E07_06235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M5E07_06245	COG0540	Belongs to the ATCase OTCase family
M5E07_06255	COG2885	chlorophyll binding
M5E07_06255	COG3047	cAMP biosynthetic process
M5E07_06275	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M5E07_06280	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M5E07_06280	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M5E07_06285	COG1254	Belongs to the acylphosphatase family
M5E07_06335	COG4774	siderophore transport
M5E07_06365	COG0010	Belongs to the arginase family
M5E07_06370	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M5E07_06380	COG0174	glutamine synthetase
M5E07_06400	COG1944	ATP diphosphatase activity
M5E07_06405	COG1252	NADH dehydrogenase
M5E07_06420	COG2814	Major facilitator Superfamily
M5E07_06430	COG4264	IucA IucC family
M5E07_06460	COG0789	Transcriptional regulator
M5E07_06475	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M5E07_06475	COG0517	IMP dehydrogenase activity
M5E07_06480	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M5E07_06490	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M5E07_06495	COG1137	ATPase activity
M5E07_06515	COG4122	O-methyltransferase activity
M5E07_06525	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M5E07_06635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E07_06645	COG1136	(ABC) transporter
M5E07_06665	COG2351	hydroxyisourate hydrolase activity
M5E07_06670	COG2207	Transcriptional regulator
M5E07_06685	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_06695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M5E07_06710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M5E07_06715	COG0183	Belongs to the thiolase family
M5E07_06720	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M5E07_06725	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M5E07_06735	COG4829	muconolactone delta-isomerase
M5E07_06740	COG4948	Mandelate Racemase Muconate Lactonizing
M5E07_06745	COG0583	DNA-binding transcription factor activity
M5E07_06785	COG4638	Rieske (2fe-2S)
M5E07_06795	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_06805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M5E07_06810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5E07_06810	COG0543	2 iron, 2 sulfur cluster binding
M5E07_06815	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M5E07_06820	COG4638	Rieske (2fe-2S)
M5E07_06845	COG3453	Protein conserved in bacteria
M5E07_06845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E07_06860	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M5E07_06890	COG1022	Amp-dependent synthetase and ligase
M5E07_06900	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_06905	COG1802	Transcriptional regulator
M5E07_06960	COG2308	Evidence 4 Homologs of previously reported genes of
M5E07_06970	COG1305	Transglutaminase-like
M5E07_06980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5E07_06985	COG0305	Participates in initiation and elongation during chromosome replication
M5E07_07000	COG0360	Binds together with S18 to 16S ribosomal RNA
M5E07_07005	COG0109	protoheme IX farnesyltransferase activity
M5E07_07010	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M5E07_07015	COG1845	cytochrome c oxidase, subunit III
M5E07_07020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M5E07_07025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M5E07_07050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E07_07065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M5E07_07070	COG2890	protein-(glutamine-N5) methyltransferase activity
M5E07_07075	COG3781	membrane
M5E07_07095	COG1960	acyl-CoA dehydrogenase activity
M5E07_07100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5E07_07130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M5E07_07140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M5E07_07165	COG0729	surface antigen
M5E07_07170	COG2911	Protein conserved in bacteria
M5E07_07220	COG0471	metal ion transport
M5E07_07255	COG0308	aminopeptidase N
M5E07_07260	COG0589	response to stress
M5E07_07280	COG3135	benzoate transporter
M5E07_07290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M5E07_07295	COG0583	DNA-binding transcription factor activity
M5E07_07305	COG0586	Pfam SNARE associated Golgi protein
M5E07_07310	COG0183	Belongs to the thiolase family
M5E07_07315	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_07325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M5E07_07330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M5E07_07335	COG0824	Thioesterase
M5E07_07340	COG1454	alcohol dehydrogenase
M5E07_07345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M5E07_07365	COG0069	glutamate synthase activity
M5E07_07370	COG2197	response regulator
M5E07_07375	COG4585	Histidine kinase
M5E07_07380	COG2850	peptidyl-arginine hydroxylation
M5E07_07385	COG0424	maF-like protein
M5E07_07410	COG0697	spore germination
M5E07_07435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M5E07_07445	COG3698	Phosphodiester glycosidase
M5E07_07460	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M5E07_07460	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M5E07_07460	COG0506	proline dehydrogenase activity
M5E07_07470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5E07_07480	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M5E07_07510	COG0316	Belongs to the HesB IscA family
M5E07_07515	COG0822	iron-sulfur transferase activity
M5E07_07540	COG0776	regulation of translation
M5E07_07545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5E07_07570	COG0537	adenosine 5'-monophosphoramidase activity
M5E07_07600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M5E07_07605	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M5E07_07620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M5E07_07630	COG0133	tryptophan synthase activity
M5E07_07635	COG0517	IMP dehydrogenase activity
M5E07_07635	COG0516	GMP reductase activity
M5E07_07660	COG0612	Peptidase, M16
M5E07_07665	COG0552	protein localization to endoplasmic reticulum
M5E07_07715	COG2814	Major facilitator Superfamily
M5E07_07725	COG2199	diguanylate cyclase activity
M5E07_07735	COG0439	Biotin carboxylase
M5E07_07740	COG0511	ligase activity, forming carbon-carbon bonds
M5E07_07785	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M5E07_07790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M5E07_07810	COG0583	DNA-binding transcription factor activity
M5E07_07815	COG1960	acyl-CoA dehydrogenase activity
M5E07_07845	COG0697	spore germination
M5E07_07850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E07_07855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E07_07860	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M5E07_07880	COG2814	Major facilitator Superfamily
M5E07_07885	COG0509	glycine decarboxylation via glycine cleavage system
M5E07_07900	COG1132	(ABC) transporter
M5E07_07925	COG1280	lysine exporter protein (LysE YggA)
M5E07_07935	COG0668	transmembrane transport
M5E07_07940	COG4774	siderophore transport
M5E07_07945	COG3122	Protein conserved in bacteria
M5E07_07965	COG0640	Transcriptional regulator
M5E07_07970	COG2937	Belongs to the GPAT DAPAT family
M5E07_07975	COG0596	Alpha beta hydrolase
M5E07_07980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E07_07985	COG1335	isochorismatase
M5E07_07990	COG0251	oxidation-reduction process
M5E07_07995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M5E07_08000	COG2233	PERMEase
M5E07_08005	COG2084	Dehydrogenase
M5E07_08010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5E07_08020	COG4770	biotin carboxylase activity
M5E07_08025	COG1024	Enoyl-CoA hydratase
M5E07_08030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M5E07_08035	COG1960	acyl-CoA dehydrogenase activity
M5E07_08040	COG1309	transcriptional regulator
M5E07_08045	COG0318	PFAM AMP-dependent synthetase and ligase
M5E07_08055	COG2226	methyltransferase
M5E07_08065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5E07_08065	COG1116	anion transmembrane transporter activity
M5E07_08075	COG2223	nitrite transmembrane transporter activity
M5E07_08080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5E07_08080	COG2146	nitrite reductase [NAD(P)H] activity
M5E07_08085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5E07_08090	COG0243	molybdopterin cofactor binding
M5E07_08100	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M5E07_08115	COG0315	cyclic pyranopterin monophosphate synthase activity
M5E07_08115	COG0521	Mo-molybdopterin cofactor biosynthetic process
M5E07_08120	COG0303	'Molybdopterin
M5E07_08125	COG0725	ABC transporter, periplasmic molybdate-binding protein
M5E07_08130	COG4149	molybdate abc transporter
M5E07_08135	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M5E07_08145	COG0475	glutathione-regulated potassium exporter activity
M5E07_08145	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M5E07_08155	COG1024	Enoyl-CoA hydratase
M5E07_08165	COG0583	DNA-binding transcription factor activity
M5E07_08180	COG1280	lysine exporter protein (LysE YggA)
M5E07_08205	COG1960	acyl-CoA dehydrogenase activity
M5E07_08210	COG1021	2,3-dihydroxybenzoate-AMP ligase
M5E07_08215	COG1012	belongs to the aldehyde dehydrogenase family
M5E07_08220	COG1024	Enoyl-CoA hydratase
M5E07_08225	COG2814	Major facilitator Superfamily
M5E07_08240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5E07_08280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M5E07_08290	COG1012	belongs to the aldehyde dehydrogenase family
M5E07_08295	COG1113	amino acid transport
M5E07_08310	COG1301	dicarboxylic acid transport
M5E07_08325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E07_08335	COG1294	oxidase, subunit
M5E07_08340	COG1271	oxidase subunit
M5E07_08350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M5E07_08355	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M5E07_08370	COG0583	DNA-binding transcription factor activity
M5E07_08375	COG3321	synthase
M5E07_08375	COG4221	oxidoreductase activity
M5E07_08375	COG0604	alcohol dehydrogenase
M5E07_08375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E07_08380	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_08400	COG1902	pentaerythritol trinitrate reductase activity
M5E07_08430	COG1309	transcriptional regulator
M5E07_08440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M5E07_08445	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5E07_08450	COG0022	dehydrogenase e1 component
M5E07_08455	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E07_08460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E07_08470	COG1063	alcohol dehydrogenase
M5E07_08485	COG1309	transcriptional regulator
M5E07_08495	COG2814	Major facilitator Superfamily
M5E07_08510	COG1309	transcriptional regulator
M5E07_08520	COG4628	conserved protein (DUF2132)
M5E07_08525	COG0596	Alpha beta hydrolase
M5E07_08545	COG0583	DNA-binding transcription factor activity
M5E07_08550	COG1380	Effector of murein hydrolase LrgA
M5E07_08555	COG1346	cytolysis
M5E07_08565	COG0406	alpha-ribazole phosphatase activity
M5E07_08570	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M5E07_08585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M5E07_08600	COG1278	Cold shock
M5E07_08620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M5E07_08625	COG2267	carboxylic ester hydrolase activity
M5E07_08630	COG0671	phosphoesterase, PA-phosphatase related
M5E07_08630	COG2453	phosphatase
M5E07_08645	COG4589	Belongs to the CDS family
M5E07_08650	COG1058	Belongs to the CinA family
M5E07_08650	COG1546	Belongs to the CinA family
M5E07_08680	COG0542	response to heat
M5E07_08685	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M5E07_08710	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M5E07_08715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M5E07_08725	COG0569	domain protein
M5E07_08730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M5E07_08750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5E07_08760	COG1585	Membrane protein implicated in regulation of membrane protease activity
M5E07_08775	COG1294	oxidase, subunit
M5E07_08780	COG4890	Cyd operon protein YbgT
M5E07_08815	COG1960	acyl-CoA dehydrogenase activity
M5E07_08820	COG1960	acyl-CoA dehydrogenase activity
M5E07_08825	COG0456	acetyltransferase
M5E07_08830	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5E07_08835	COG2207	Transcriptional regulator
M5E07_08840	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M5E07_08845	COG4773	Receptor
M5E07_08865	COG0730	response to heat
M5E07_08895	COG0772	Belongs to the SEDS family
M5E07_08910	COG0148	phosphopyruvate hydratase activity
M5E07_08945	COG1902	pentaerythritol trinitrate reductase activity
M5E07_08945	COG0446	pyridine nucleotide-disulphide oxidoreductase
M5E07_08955	COG2267	carboxylic ester hydrolase activity
M5E07_08960	COG0583	DNA-binding transcription factor activity
M5E07_08965	COG4948	Mandelate Racemase Muconate Lactonizing
M5E07_08970	COG4829	muconolactone delta-isomerase
M5E07_08980	COG4638	Rieske (2fe-2S)
M5E07_08985	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M5E07_08990	COG0543	2 iron, 2 sulfur cluster binding
M5E07_08990	COG0633	Ferredoxin
M5E07_08995	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_09000	COG3135	benzoate transporter
M5E07_09005	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M5E07_09010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M5E07_09015	COG0183	Belongs to the thiolase family
M5E07_09020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M5E07_09030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M5E07_09035	COG1960	acyl-CoA dehydrogenase activity
M5E07_09040	COG0583	DNA-binding transcription factor activity
M5E07_09045	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M5E07_09055	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M5E07_09060	COG0702	epimerase
M5E07_09085	COG1011	Hydrolase
M5E07_09090	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M5E07_09100	COG2137	regulation of response to DNA damage stimulus
M5E07_09115	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M5E07_09135	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M5E07_09150	COG0575	Belongs to the CDS family
M5E07_09155	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M5E07_09170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M5E07_09175	COG3852	Histidine kinase
M5E07_09190	COG0583	DNA-binding transcription factor activity
M5E07_09195	COG0024	Methionine aminopeptidase
M5E07_09220	COG1253	flavin adenine dinucleotide binding
M5E07_09235	COG0582	viral genome integration into host DNA
M5E07_09265	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_09410	COG5410	chromosome segregation
M5E07_09435	COG1598	PFAM Uncharacterised protein family UPF0150
M5E07_09575	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M5E07_09580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M5E07_09590	COG2431	L-lysine efflux transmembrane transporter activity
M5E07_09670	COG1309	transcriptional regulator
M5E07_09675	COG0084	hydrolase, TatD family'
M5E07_09695	COG1663	tetraacyldisaccharide 4'-kinase activity
M5E07_09700	COG1132	(ABC) transporter
M5E07_09710	COG0811	peptide transport
M5E07_09715	COG1475	DNA binding
M5E07_09720	COG1192	Involved in chromosome partitioning
M5E07_09730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M5E07_09745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5E07_09750	COG1923	regulation of RNA biosynthetic process
M5E07_09755	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M5E07_09760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M5E07_09765	COG0802	atpase or kinase
M5E07_09790	COG2707	UPF0756 membrane protein
M5E07_09795	COG0583	DNA-binding transcription factor activity
M5E07_09800	COG2814	Major facilitator Superfamily
M5E07_09805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M5E07_09810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M5E07_09820	COG1454	alcohol dehydrogenase
M5E07_09840	COG0519	Catalyzes the synthesis of GMP from XMP
M5E07_09840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M5E07_09845	COG2353	YceI-like domain
M5E07_09850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M5E07_09890	COG2815	serine threonine protein kinase
M5E07_09890	COG0515	serine threonine protein kinase
M5E07_09915	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M5E07_09925	COG1610	YqeY-like protein
M5E07_09940	COG4783	chaperone-mediated protein folding
M5E07_09970	COG0167	dihydroorotate dehydrogenase activity
M5E07_09995	COG0778	Nitroreductase
M5E07_10005	COG0513	Belongs to the DEAD box helicase family
M5E07_10025	COG2363	Small membrane protein
M5E07_10045	COG0625	glutathione transferase activity
M5E07_10050	COG0659	secondary active sulfate transmembrane transporter activity
M5E07_10055	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M5E07_10075	COG4772	TonB-dependent receptor
M5E07_10080	COG4993	Dehydrogenase
M5E07_10085	COG3659	wide pore channel activity
M5E07_10090	COG3420	alginic acid biosynthetic process
M5E07_10095	COG0710	3-dehydroquinate dehydratase activity
M5E07_10100	COG3485	protocatechuate 3,4-dioxygenase
M5E07_10105	COG3485	protocatechuate 3,4-dioxygenase
M5E07_10110	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M5E07_10115	COG2271	Major facilitator Superfamily
M5E07_10120	COG0596	Alpha beta hydrolase
M5E07_10125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M5E07_10130	COG0183	Belongs to the thiolase family
M5E07_10135	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M5E07_10140	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M5E07_10145	COG1414	Transcriptional regulator
M5E07_10150	COG0531	amino acid
M5E07_10160	COG2814	Major facilitator Superfamily
M5E07_10170	COG0445	tRNA wobble uridine modification
M5E07_10195	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M5E07_10200	COG0138	bifunctional purine biosynthesis protein purh
M5E07_10205	COG0151	Belongs to the GarS family
M5E07_10210	COG1464	Belongs to the NlpA lipoprotein family
M5E07_10215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M5E07_10220	COG2011	ABC-type metal ion transport system permease component
M5E07_10245	COG1045	serine acetyltransferase
M5E07_10260	COG0318	PFAM AMP-dependent synthetase and ligase
M5E07_10275	COG0579	oxidoreductase
M5E07_10350	COG1518	maintenance of DNA repeat elements
M5E07_10355	COG0204	Acyl-transferase
M5E07_10390	COG1464	Belongs to the NlpA lipoprotein family
M5E07_10395	COG1464	Belongs to the NlpA lipoprotein family
M5E07_10400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M5E07_10405	COG2011	ABC-type metal ion transport system permease component
M5E07_10410	COG0012	GTP binding
M5E07_10415	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M5E07_10440	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M5E07_10475	COG2207	Transcriptional regulator
M5E07_10475	COG1917	Cupin 2, conserved barrel domain protein
M5E07_10480	COG0386	Belongs to the glutathione peroxidase family
M5E07_10485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5E07_10490	COG0436	Aminotransferase
M5E07_10530	COG0612	Peptidase, M16
M5E07_10540	COG1823	symporter activity
M5E07_10545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M5E07_10565	COG0753	catalase activity
M5E07_10585	COG2050	protein possibly involved in aromatic compounds catabolism
M5E07_10590	COG2351	hydroxyisourate hydrolase activity
M5E07_10600	COG1686	Belongs to the peptidase S11 family
M5E07_10605	COG1252	NADH dehydrogenase
M5E07_10615	COG0415	Belongs to the DNA photolyase family
M5E07_10645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M5E07_10655	COG0693	protein deglycase activity
M5E07_10660	COG1960	acyl-CoA dehydrogenase activity
M5E07_10665	COG1301	dicarboxylic acid transport
M5E07_10675	COG3139	Protein of unknown function (DUF1315)
M5E07_10680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M5E07_10685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5E07_10705	COG0642	Histidine kinase
M5E07_10720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5E07_10730	COG2203	Gaf domain
M5E07_10730	COG2199	diguanylate cyclase activity
M5E07_10735	COG1720	tRNA m6t6A37 methyltransferase activity
M5E07_10770	COG0826	peptidase U32
M5E07_10775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M5E07_10780	COG3634	alkyl hydroperoxide reductase activity
M5E07_10810	COG1643	Atp-dependent helicase
M5E07_10855	COG0564	pseudouridine synthase activity
M5E07_10860	COG3193	protein, possibly involved in utilization of glycolate and propanediol
M5E07_10875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M5E07_10905	COG0402	S-adenosylhomocysteine deaminase activity
M5E07_10925	COG2985	domain, Protein
M5E07_10940	COG1131	(ABC) transporter
M5E07_10945	COG0842	Transport permease protein
M5E07_10960	COG0772	Belongs to the SEDS family
M5E07_10965	COG2951	lytic endotransglycosylase activity
M5E07_11010	COG0052	Belongs to the universal ribosomal protein uS2 family
M5E07_11025	COG2223	nitrite transmembrane transporter activity
M5E07_11040	COG2175	clavaminate synthase activity
M5E07_11045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E07_11050	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M5E07_11070	COG0583	DNA-binding transcription factor activity
M5E07_11080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M5E07_11095	COG0657	acetylesterase activity
M5E07_11100	COG0047	phosphoribosylformylglycinamidine synthase activity
M5E07_11100	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M5E07_11110	COG0632	four-way junction helicase activity
M5E07_11115	COG2255	four-way junction helicase activity
M5E07_11130	COG0824	Thioesterase
M5E07_11150	COG0823	Involved in the tonB-independent uptake of proteins
M5E07_11170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5E07_11200	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M5E07_11205	COG0628	permease
M5E07_11215	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M5E07_11235	COG2333	competence protein COMEC
M5E07_11235	COG0658	competence protein
M5E07_11240	COG1136	(ABC) transporter
M5E07_11245	COG4591	ABC-type transport system involved in lipoprotein release permease component
M5E07_11260	COG1671	Belongs to the UPF0178 family
M5E07_11295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E07_11310	COG1301	dicarboxylic acid transport
M5E07_11325	COG2318	DinB family
M5E07_11340	COG1280	lysine exporter protein (LysE YggA)
M5E07_11345	COG1522	sequence-specific DNA binding
M5E07_11350	COG0519	Catalyzes the synthesis of GMP from XMP
M5E07_11360	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M5E07_11375	COG0019	diaminopimelate decarboxylase activity
M5E07_11385	COG1113	amino acid transport
M5E07_11390	COG1115	amino acid carrier protein
M5E07_11430	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M5E07_11445	COG0174	glutamine synthetase
M5E07_11560	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M5E07_11575	COG1802	Transcriptional regulator
M5E07_11580	COG2217	Heavy metal translocating P-type atpase
M5E07_11590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M5E07_11605	COG2234	aminopeptidase activity
M5E07_11615	COG3384	dioxygenase
M5E07_11625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5E07_11630	COG2878	Part of a membrane complex involved in electron transport
M5E07_11635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M5E07_11660	COG0768	penicillin binding
M5E07_11665	COG0742	ribosomal rna small subunit methyltransferase
M5E07_11695	COG0583	DNA-binding transcription factor activity
M5E07_11700	COG2814	Major facilitator Superfamily
M5E07_11705	COG1309	transcriptional regulator
M5E07_11710	COG1607	acyl-coa hydrolase
M5E07_11715	COG1752	Esterase of the alpha-beta hydrolase superfamily
M5E07_11720	COG1115	amino acid carrier protein
M5E07_11725	COG0786	glutamate:sodium symporter activity
M5E07_11740	COG2321	neutral zinc metallopeptidase
M5E07_11745	COG2354	Protein conserved in bacteria
M5E07_11755	COG1585	Membrane protein implicated in regulation of membrane protease activity
M5E07_11760	COG2268	Band 7 protein
M5E07_11780	COG3733	amine oxidase
M5E07_11790	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M5E07_11800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E07_11815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M5E07_11820	COG1053	succinate dehydrogenase
M5E07_11825	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M5E07_11830	COG2009	succinate dehydrogenase
M5E07_11840	COG2072	flavoprotein involved in K transport
M5E07_11845	COG0300	oxidoreductase activity
M5E07_11860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M5E07_11860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M5E07_11880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M5E07_11905	COG0564	pseudouridine synthase activity
M5E07_11930	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M5E07_11960	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M5E07_11980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5E07_12005	COG0586	Pfam SNARE associated Golgi protein
M5E07_12030	COG2921	Belongs to the UPF0250 family
M5E07_12035	COG0321	lipoyl(octanoyl) transferase activity
M5E07_12050	COG0531	amino acid
M5E07_12070	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M5E07_12075	COG1648	precorrin-2 dehydrogenase activity
M5E07_12075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M5E07_12080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M5E07_12090	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M5E07_12095	COG5295	Hep Hag repeat protein
M5E07_12105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M5E07_12110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M5E07_12125	COG0671	phosphoesterase, PA-phosphatase related
M5E07_12130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E07_12140	COG1538	Outer membrane efflux protein
M5E07_12145	COG0393	Putative heavy-metal-binding
M5E07_12155	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_12165	COG0525	valine-tRNA ligase activity
M5E07_12175	COG2852	Protein conserved in bacteria
M5E07_12190	COG0765	amino acid transport
M5E07_12195	COG0765	amino acid transport
M5E07_12200	COG1126	abc transporter atp-binding protein
M5E07_12205	COG0004	ammonium transporteR
M5E07_12210	COG1011	Hydrolase
M5E07_12220	COG0642	Histidine kinase
M5E07_12225	COG0745	RESPONSE REGULATOR receiver
M5E07_12230	COG2194	sulfuric ester hydrolase activity
M5E07_12240	COG2814	Major facilitator Superfamily
M5E07_12250	COG1752	Esterase of the alpha-beta hydrolase superfamily
M5E07_12265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5E07_12270	COG0142	geranyltranstransferase activity
M5E07_12275	COG2199	diguanylate cyclase activity
M5E07_12280	COG2828	Protein conserved in bacteria
M5E07_12285	COG1113	amino acid transport
M5E07_12295	COG0582	viral genome integration into host DNA
M5E07_12335	COG3177	Filamentation induced by cAMP protein fic
M5E07_12345	COG2801	Transposase and inactivated derivatives
M5E07_12360	COG0745	RESPONSE REGULATOR receiver
M5E07_12365	COG2205	protein histidine kinase activity
M5E07_12370	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
M5E07_12375	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M5E07_12380	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M5E07_12410	COG4716	Myosin-crossreactive antigen
M5E07_12425	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M5E07_12430	COG2081	HI0933 family
M5E07_12440	COG0668	transmembrane transport
M5E07_12450	COG4303	Ethanolamine ammonia lyase large subunit
M5E07_12455	COG0531	amino acid
M5E07_12475	COG0583	DNA-binding transcription factor activity
M5E07_12485	COG1278	Cold shock
M5E07_12490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M5E07_12500	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M5E07_12505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M5E07_12510	COG0713	ATP synthesis coupled electron transport
M5E07_12520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M5E07_12535	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M5E07_12545	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M5E07_12545	COG0649	NAD binding
M5E07_12565	COG2205	protein histidine kinase activity
M5E07_12570	COG0745	RESPONSE REGULATOR receiver
M5E07_12575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5E07_12575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M5E07_12585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5E07_12600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E07_12620	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_12635	COG1399	metal-binding, possibly nucleic acid-binding protein
M5E07_12640	COG3101	peptidyl-lysine hydroxylation
M5E07_12645	COG0009	L-threonylcarbamoyladenylate synthase
M5E07_12650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M5E07_12655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M5E07_12670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E07_12680	COG0339	signal peptide processing
M5E07_12690	COG4166	transmembrane transport
M5E07_12730	COG4106	trans-aconitate 2-methyltransferase activity
M5E07_12740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M5E07_12740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M5E07_12745	COG2226	methyltransferase
M5E07_12745	COG0596	Alpha beta hydrolase
M5E07_12745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M5E07_12750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M5E07_12760	COG2193	ferroxidase activity
M5E07_12765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5E07_12770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M5E07_12780	COG1196	nuclear chromosome segregation
M5E07_12790	COG0730	response to heat
M5E07_12800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M5E07_12810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M5E07_12830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5E07_12840	COG3422	double-strand break repair
M5E07_12850	COG2824	Alkylphosphonate utilization operon protein PhnA
M5E07_12860	COG3189	MarR family transcriptional regulator
M5E07_12880	COG0564	pseudouridine synthase activity
M5E07_12915	COG0354	folic acid binding
M5E07_12940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E07_12955	COG0424	maF-like protein
M5E07_12960	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M5E07_12965	COG1792	Involved in formation and maintenance of cell shape
M5E07_12970	COG1077	Cell shape determining protein MreB Mrl
M5E07_12975	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M5E07_12985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M5E07_12995	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5E07_13040	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M5E07_13055	COG0679	Auxin Efflux Carrier
M5E07_13070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5E07_13080	COG1970	mechanosensitive ion channel activity
M5E07_13085	COG1217	gtp-binding protein TYPA
M5E07_13090	COG2233	PERMEase
M5E07_13095	COG2813	Specifically methylates the guanine in position
M5E07_13100	COG0833	amino acid
M5E07_13130	COG0183	Belongs to the thiolase family
M5E07_13145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5E07_13165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M5E07_13170	COG2207	Transcriptional regulator
M5E07_13185	COG0183	Belongs to the thiolase family
M5E07_13210	COG1272	protein, Hemolysin III
M5E07_13215	COG0477	Major facilitator Superfamily
M5E07_13220	COG1408	metallophosphoesterase
M5E07_13225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E07_13235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M5E07_13265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M5E07_13270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M5E07_13275	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M5E07_13280	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M5E07_13285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M5E07_13290	COG0625	glutathione transferase activity
M5E07_13295	COG2969	positive regulation of protein catabolic process
M5E07_13355	COG2199	diguanylate cyclase activity
M5E07_13385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M5E07_13390	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M5E07_13405	COG0450	alkyl hydroperoxide reductase
M5E07_13425	COG0285	dihydrofolate synthase activity
M5E07_13430	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M5E07_13475	COG4206	TonB-dependent receptor
M5E07_13480	COG2096	Adenosyltransferase
M5E07_13500	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M5E07_13515	COG0745	RESPONSE REGULATOR receiver
M5E07_13520	COG2205	protein histidine kinase activity
M5E07_13530	COG1960	acyl-CoA dehydrogenase activity
M5E07_13535	COG1960	acyl-CoA dehydrogenase activity
M5E07_13555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E07_13570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M5E07_13585	COG0438	transferase activity, transferring glycosyl groups
M5E07_13600	COG1215	transferase activity, transferring glycosyl groups
M5E07_13605	COG0726	polysaccharide deacetylase
M5E07_13620	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M5E07_13625	COG5002	protein histidine kinase activity
M5E07_13630	COG3706	GGDEF domain
M5E07_13640	COG0793	Belongs to the peptidase S41A family
M5E07_13670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M5E07_13675	COG0857	belongs to the CobB CobQ family
M5E07_13675	COG0280	phosphate acetyltransferase
M5E07_13680	COG2226	methyltransferase
M5E07_13695	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M5E07_13695	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M5E07_13715	COG0740	serine-type endopeptidase activity
M5E07_13725	COG4771	TonB-dependent receptor
M5E07_13730	COG4774	siderophore transport
M5E07_13740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M5E07_13750	COG2813	Specifically methylates the guanine in position
M5E07_13750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M5E07_13765	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M5E07_13860	COG0788	formyltetrahydrofolate deformylase activity
M5E07_13885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M5E07_13885	COG4651	solute:proton antiporter activity
M5E07_13905	COG0724	RNA recognition motif
M5E07_13915	COG1929	Belongs to the glycerate kinase type-1 family
M5E07_13950	COG2900	Belongs to the SlyX family
M5E07_13955	COG0488	(ABC) transporter
M5E07_13970	COG1560	Kdo2-lipid A biosynthetic process
M5E07_14000	COG0252	asparaginase activity
M5E07_14025	COG0473	3-isopropylmalate dehydrogenase activity
M5E07_14080	COG1846	Transcriptional regulator
M5E07_14090	COG1960	acyl-CoA dehydrogenase activity
M5E07_14120	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M5E07_14140	COG0446	pyridine nucleotide-disulphide oxidoreductase
M5E07_14145	COG3384	dioxygenase
M5E07_14150	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_14165	COG4638	Rieske (2fe-2S)
M5E07_14170	COG0583	DNA-binding transcription factor activity
M5E07_14195	COG4569	acetaldehyde dehydrogenase (acetylating) activity
M5E07_14200	COG3971	2-oxopent-4-enoate hydratase activity
M5E07_14205	COG0625	glutathione transferase activity
M5E07_14210	COG2378	regulation of single-species biofilm formation
M5E07_14215	COG0546	phosphoglycolate phosphatase activity
M5E07_14225	COG1530	ribonuclease E activity
M5E07_14230	COG0318	PFAM AMP-dependent synthetase and ligase
M5E07_14255	COG1983	PspC domain protein
M5E07_14260	COG0517	IMP dehydrogenase activity
M5E07_14260	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M5E07_14260	COG0617	tRNA 3'-terminal CCA addition
M5E07_14275	COG0751	glycine-tRNA ligase activity
M5E07_14300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5E07_14330	COG0493	'glutamate synthase
M5E07_14340	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M5E07_14355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E07_14370	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M5E07_14380	COG0644	oxidoreductase
M5E07_14380	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
M5E07_14395	COG4535	Mg2 and Co2 transporter CorC
M5E07_14400	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M5E07_14420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M5E07_14430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M5E07_14440	COG0484	heat shock protein binding
M5E07_14445	COG0789	Transcriptional regulator
M5E07_14450	COG2841	Protein conserved in bacteria
M5E07_14455	COG0598	Magnesium transport protein CorA
M5E07_14460	COG1185	polyribonucleotide nucleotidyltransferase activity
M5E07_14465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M5E07_14470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M5E07_14475	COG1074	ATP-dependent DNA helicase activity
M5E07_14480	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M5E07_14510	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M5E07_14520	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M5E07_14535	COG2111	Na H antiporter
M5E07_14535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M5E07_14540	COG1006	Multisubunit Na H antiporter MnhC subunit
M5E07_14545	COG0651	ATP synthesis coupled electron transport
M5E07_14550	COG1863	multisubunit Na H antiporter MnhE subunit
M5E07_14555	COG2212	antiporter activity
M5E07_14560	COG1320	monovalent cation:proton antiporter activity
M5E07_14565	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M5E07_14570	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M5E07_14575	COG0195	Participates in both transcription termination and antitermination
M5E07_14580	COG0779	Required for maturation of 30S ribosomal subunits
M5E07_14630	COG0237	dephospho-CoA kinase activity
M5E07_14640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5E07_14645	COG3123	guanosine phosphorylase activity
M5E07_14650	COG0497	DNA recombination
M5E07_14660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M5E07_14675	COG1289	transmembrane transporter activity
M5E07_14685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M5E07_14700	COG1733	regulation of RNA biosynthetic process
M5E07_14765	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M5E07_14795	COG0326	Molecular chaperone. Has ATPase activity
M5E07_14810	COG2056	Na+-H+ antiporter family
M5E07_14840	COG0085	RNA polymerase activity
M5E07_14845	COG0222	ribosome binding
M5E07_14850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M5E07_14855	COG0081	regulation of translation
M5E07_14860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M5E07_14870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M5E07_14880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M5E07_14910	COG0546	phosphoglycolate phosphatase activity
M5E07_14915	COG1716	ATPase activity
M5E07_14940	COG0824	Thioesterase
M5E07_14960	COG0181	hydroxymethylbilane synthase activity
M5E07_14970	COG3275	phosphorelay sensor kinase activity
M5E07_14990	COG1538	Outer membrane efflux protein
M5E07_15005	COG0494	nUDIX hydrolase
M5E07_15010	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M5E07_15015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M5E07_15020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M5E07_15025	COG0772	Belongs to the SEDS family
M5E07_15050	COG4974	Belongs to the 'phage' integrase family
M5E07_15055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5E07_15065	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M5E07_15085	COG2197	response regulator
M5E07_15090	COG3852	Histidine kinase
M5E07_15100	COG0793	Belongs to the peptidase S41A family
M5E07_15105	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M5E07_15110	COG0795	lipopolysaccharide-transporting ATPase activity
M5E07_15115	COG0795	lipopolysaccharide-transporting ATPase activity
M5E07_15140	COG0586	Pfam SNARE associated Golgi protein
M5E07_15155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5E07_15155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5E07_15165	COG0004	ammonium transporteR
M5E07_15170	COG0347	Belongs to the P(II) protein family
M5E07_15180	COG0606	chelatase, subunit chli
M5E07_15195	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M5E07_15210	COG0318	PFAM AMP-dependent synthetase and ligase
M5E07_15220	COG0477	Major facilitator Superfamily
M5E07_15225	COG2860	membrane
M5E07_15235	COG1253	flavin adenine dinucleotide binding
M5E07_15250	COG0477	Major facilitator Superfamily
M5E07_15260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M5E07_15280	COG2814	Major facilitator Superfamily
M5E07_15340	COG1652	LysM domain
M5E07_15345	COG0758	DNA mediated transformation
M5E07_15355	COG0697	spore germination
M5E07_15365	COG0386	Belongs to the glutathione peroxidase family
M5E07_15395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M5E07_15445	COG1121	(ABC) transporter
M5E07_15450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5E07_15460	COG2837	iron assimilation
M5E07_15500	COG0281	malic enzyme
M5E07_15565	COG0519	Catalyzes the synthesis of GMP from XMP
M5E07_15565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M5E07_15570	COG2259	Doxx family
M5E07_15575	COG0586	Pfam SNARE associated Golgi protein
M5E07_15590	COG1192	Involved in chromosome partitioning
M5E07_15600	COG0271	Belongs to the BolA IbaG family
M5E07_15620	COG1113	amino acid transport
M5E07_15630	COG3724	N-succinylarginine dihydrolase activity
M5E07_15635	COG1012	belongs to the aldehyde dehydrogenase family
M5E07_15650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5E07_15665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M5E07_15680	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M5E07_15690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M5E07_15695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5E07_15705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M5E07_15715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5E07_15730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M5E07_15740	COG1215	transferase activity, transferring glycosyl groups
M5E07_15750	COG0438	transferase activity, transferring glycosyl groups
M5E07_15785	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M5E07_15790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M5E07_15795	COG1216	Glycosyl transferase, family 2
M5E07_15805	COG0438	transferase activity, transferring glycosyl groups
M5E07_15815	COG2244	polysaccharide biosynthetic process
M5E07_15825	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_15840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M5E07_15850	COG2089	acid synthase
M5E07_15855	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M5E07_15860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5E07_15870	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M5E07_15875	COG1596	polysaccharide export
M5E07_15900	COG0728	peptidoglycan biosynthetic process
M5E07_15925	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M5E07_15935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5E07_15940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M5E07_15945	COG0546	phosphoglycolate phosphatase activity
M5E07_15950	COG1028	Short-chain dehydrogenase reductase Sdr
M5E07_15970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M5E07_15970	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M5E07_15975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5E07_15980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5E07_15985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E07_15990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M5E07_15995	COG1116	anion transmembrane transporter activity
M5E07_16000	COG1309	transcriptional regulator
M5E07_16005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M5E07_16015	COG0196	riboflavin kinase activity
M5E07_16020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M5E07_16030	COG1047	Peptidyl-prolyl cis-trans
M5E07_16050	COG0129	dihydroxy-acid dehydratase activity
M5E07_16065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M5E07_16065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M5E07_16070	COG0428	transporter
M5E07_16080	COG0733	neurotransmitter:sodium symporter activity
M5E07_16135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M5E07_16140	COG0657	acetylesterase activity
M5E07_16155	COG0583	DNA-binding transcription factor activity
M5E07_16180	COG2951	lytic endotransglycosylase activity
M5E07_16185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M5E07_16200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M5E07_16205	COG2388	GCN5-related N-acetyl-transferase
M5E07_16210	COG0861	Integral membrane protein TerC family
M5E07_16215	COG0402	S-adenosylhomocysteine deaminase activity
M5E07_16230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5E07_16235	COG1230	cation diffusion facilitator family transporter
M5E07_16255	COG0706	membrane insertase activity
M5E07_16260	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M5E07_16265	COG0594	ribonuclease P activity