locus-tag	class	description
NGC85_00010	COG0592	DNA-directed DNA polymerase activity
NGC85_00020	COG0187	DNA topoisomerase II activity
NGC85_00025	COG0586	Pfam SNARE associated Golgi protein
NGC85_00030	COG0488	(ABC) transporter
NGC85_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NGC85_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NGC85_00110	COG0471	metal ion transport
NGC85_00110	COG3273	potassium ion transport
NGC85_00120	COG1012	belongs to the aldehyde dehydrogenase family
NGC85_00125	COG3738	Protein conserved in bacteria
NGC85_00130	COG0733	neurotransmitter:sodium symporter activity
NGC85_00170	COG0583	DNA-binding transcription factor activity
NGC85_00180	COG2233	PERMEase
NGC85_00190	COG1309	transcriptional regulator
NGC85_00195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NGC85_00225	COG2814	Major facilitator Superfamily
NGC85_00230	COG0656	L-ascorbic acid biosynthetic process
NGC85_00235	COG0583	DNA-binding transcription factor activity
NGC85_00250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NGC85_00255	COG1064	alcohol dehydrogenase
NGC85_00260	COG2818	Glycosylase
NGC85_00275	COG1194	a g-specific adenine glycosylase
NGC85_00285	COG5487	UPF0391 membrane protein
NGC85_00290	COG2983	Belongs to the UPF0260 family
NGC85_00295	COG2133	pyrroloquinoline quinone binding
NGC85_00305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NGC85_00310	COG0697	spore germination
NGC85_00320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NGC85_00330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NGC85_00335	COG1335	isochorismatase
NGC85_00340	COG1522	sequence-specific DNA binding
NGC85_00350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NGC85_00360	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NGC85_00365	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NGC85_00390	COG0560	Phosphoserine phosphatase
NGC85_00390	COG3830	Belongs to the UPF0237 family
NGC85_00435	COG1278	Cold shock
NGC85_00440	COG0583	DNA-binding transcription factor activity
NGC85_00450	COG0583	DNA-binding transcription factor activity
NGC85_00485	COG0534	Mate efflux family protein
NGC85_00490	COG0436	Aminotransferase
NGC85_00500	COG2733	membrane
NGC85_00515	COG2918	glutathione biosynthetic process
NGC85_00560	COG3150	esterase
NGC85_00570	COG0534	Mate efflux family protein
NGC85_00605	COG1247	-acetyltransferase
NGC85_00660	COG1393	Belongs to the ArsC family
NGC85_00665	COG0708	Exodeoxyribonuclease III
NGC85_00680	COG0300	oxidoreductase activity
NGC85_00705	COG0386	Belongs to the glutathione peroxidase family
NGC85_00710	COG0189	ligase activity
NGC85_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NGC85_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NGC85_00775	COG2119	membrane
NGC85_00780	COG3293	Transposase
NGC85_00785	COG4774	siderophore transport
NGC85_00790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NGC85_00790	COG0426	domain, Protein
NGC85_00815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NGC85_00835	COG1902	pentaerythritol trinitrate reductase activity
NGC85_00840	COG1519	Transferase
NGC85_00845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NGC85_00850	COG0668	transmembrane transport
NGC85_00860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NGC85_00865	COG1335	isochorismatase
NGC85_00870	COG1522	sequence-specific DNA binding
NGC85_00895	COG3706	GGDEF domain
NGC85_00905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NGC85_00910	COG1309	transcriptional regulator
NGC85_00915	COG3321	synthase
NGC85_00915	COG1028	Short-chain dehydrogenase reductase Sdr
NGC85_00915	COG0604	alcohol dehydrogenase
NGC85_00925	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NGC85_00935	COG2814	Major facilitator Superfamily
NGC85_00985	COG2207	Transcriptional regulator
NGC85_00990	COG0633	Ferredoxin
NGC85_01015	COG1309	transcriptional regulator
NGC85_01050	COG1113	amino acid transport
NGC85_01060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NGC85_01065	COG1012	belongs to the aldehyde dehydrogenase family
NGC85_01075	COG1335	isochorismatase
NGC85_01085	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NGC85_01100	COG3177	Filamentation induced by cAMP protein fic
NGC85_01205	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NGC85_01215	COG0582	viral genome integration into host DNA
NGC85_01225	COG3158	transport of potassium into the cell
NGC85_01260	COG0107	imidazoleglycerol-phosphate synthase activity
NGC85_01265	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NGC85_01280	COG3293	Transposase
NGC85_01285	COG2329	Antibiotic biosynthesis monooxygenase
NGC85_01290	COG3293	Transposase
NGC85_01305	COG0659	secondary active sulfate transmembrane transporter activity
NGC85_01325	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NGC85_01350	COG2067	long-chain fatty acid transport protein
NGC85_01355	COG0427	acetyl-CoA hydrolase
NGC85_01405	COG1028	Short-chain dehydrogenase reductase Sdr
NGC85_01410	COG0583	DNA-binding transcription factor activity
NGC85_01420	COG0477	Major facilitator Superfamily
NGC85_01425	COG0789	Transcriptional regulator
NGC85_01430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NGC85_01430	COG3320	Male sterility
NGC85_01435	COG4221	oxidoreductase activity
NGC85_01445	COG0488	(ABC) transporter
NGC85_01515	COG0833	amino acid
NGC85_01540	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NGC85_01560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NGC85_01565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NGC85_01575	COG2226	methyltransferase
NGC85_01625	COG0069	glutamate synthase activity
NGC85_01625	COG0067	glutamate synthase
NGC85_01625	COG0070	glutamate synthase
NGC85_01630	COG0493	'glutamate synthase
NGC85_01640	COG1704	LemA family
NGC85_01645	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NGC85_01655	COG4969	Belongs to the N-Me-Phe pilin family
NGC85_01660	COG4969	Belongs to the N-Me-Phe pilin family
NGC85_01675	COG3307	-O-antigen
NGC85_01695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NGC85_01705	COG0194	GDP metabolic process
NGC85_01715	COG4969	Belongs to the N-Me-Phe pilin family
NGC85_01780	COG0228	four-way junction DNA binding
NGC85_01785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NGC85_01795	COG0335	large ribosomal subunit rRNA binding
NGC85_01800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NGC85_01820	COG5006	permease, DMT superfamily
NGC85_01825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NGC85_01830	COG0277	FAD linked oxidase domain protein
NGC85_01840	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NGC85_01845	COG2249	NAD(P)H dehydrogenase (quinone) activity
NGC85_01865	COG1289	transmembrane transporter activity
NGC85_01870	COG2032	superoxide dismutase activity
NGC85_01875	COG0628	permease
NGC85_01880	COG1192	Involved in chromosome partitioning
NGC85_01890	COG2226	methyltransferase
NGC85_01925	COG1404	Belongs to the peptidase S8 family
NGC85_01965	COG0752	glycyl-tRNA synthetase alpha subunit
NGC85_01990	COG0471	metal ion transport
NGC85_02000	COG0517	IMP dehydrogenase activity
NGC85_02005	COG1983	PspC domain protein
NGC85_02015	COG1960	acyl-CoA dehydrogenase activity
NGC85_02030	COG0406	alpha-ribazole phosphatase activity
NGC85_02035	COG0408	coproporphyrinogen oxidase activity
NGC85_02060	COG0513	Belongs to the DEAD box helicase family
NGC85_02065	COG1127	ABC transporter
NGC85_02070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NGC85_02075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NGC85_02080	COG2854	intermembrane phospholipid transfer
NGC85_02095	COG0598	Magnesium transport protein CorA
NGC85_02100	COG0494	nUDIX hydrolase
NGC85_02105	COG1040	competence protein
NGC85_02110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NGC85_02125	COG2937	Belongs to the GPAT DAPAT family
NGC85_02130	COG1946	Acyl-CoA thioesterase
NGC85_02135	COG1301	dicarboxylic acid transport
NGC85_02150	COG1959	2 iron, 2 sulfur cluster binding
NGC85_02160	COG0433	COG0433 Predicted ATPase
NGC85_02180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NGC85_02200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NGC85_02205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NGC85_02245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NGC85_02260	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NGC85_02265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NGC85_02330	COG1960	acyl-CoA dehydrogenase activity
NGC85_02335	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NGC85_02370	COG0697	spore germination
NGC85_02385	COG0339	signal peptide processing
NGC85_02395	COG3293	Transposase
NGC85_02400	COG0557	exoribonuclease II activity
NGC85_02440	COG0179	Fumarylacetoacetate (FAA) hydrolase
NGC85_02460	COG1295	ribonuclease BN
NGC85_02490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NGC85_02515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NGC85_02515	COG2813	Specifically methylates the guanine in position
NGC85_02525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NGC85_02535	COG3128	pkhd-type hydroxylase
NGC85_02540	COG4774	siderophore transport
NGC85_02550	COG0740	serine-type endopeptidase activity
NGC85_02570	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NGC85_02570	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NGC85_02585	COG0280	phosphate acetyltransferase
NGC85_02585	COG0857	belongs to the CobB CobQ family
NGC85_02590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NGC85_02615	COG0793	Belongs to the peptidase S41A family
NGC85_02640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NGC85_02650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NGC85_02655	COG1408	metallophosphoesterase
NGC85_02660	COG2885	chlorophyll binding
NGC85_02665	COG2199	diguanylate cyclase activity
NGC85_02720	COG1960	acyl-CoA dehydrogenase activity
NGC85_02725	COG1960	acyl-CoA dehydrogenase activity
NGC85_02740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NGC85_02745	COG1309	transcriptional regulator
NGC85_02760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NGC85_02765	COG1960	acyl-CoA dehydrogenase activity
NGC85_02820	COG2969	positive regulation of protein catabolic process
NGC85_02835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NGC85_02840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NGC85_02850	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NGC85_02855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NGC85_02860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NGC85_02875	COG2975	iron-sulfur cluster assembly
NGC85_02915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NGC85_02930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NGC85_02940	COG1862	Preprotein translocase
NGC85_02970	COG2205	protein histidine kinase activity
NGC85_02975	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NGC85_02985	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NGC85_02995	COG0438	transferase activity, transferring glycosyl groups
NGC85_03020	COG1216	Glycosyl transferase, family 2
NGC85_03020	COG0463	Glycosyl transferase, family 2
NGC85_03035	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NGC85_03055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NGC85_03100	COG1960	acyl-CoA dehydrogenase activity
NGC85_03105	COG1960	acyl-CoA dehydrogenase activity
NGC85_03115	COG2205	protein histidine kinase activity
NGC85_03120	COG0745	RESPONSE REGULATOR receiver
NGC85_03135	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NGC85_03155	COG2096	Adenosyltransferase
NGC85_03160	COG4206	TonB-dependent receptor
NGC85_03215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NGC85_03220	COG0285	dihydrofolate synthase activity
NGC85_03245	COG0450	alkyl hydroperoxide reductase
NGC85_03265	COG0477	Major facilitator Superfamily
NGC85_03270	COG1272	protein, Hemolysin III
NGC85_03280	COG2153	protein acetylation
NGC85_03305	COG0183	Belongs to the thiolase family
NGC85_03325	COG0454	-acetyltransferase
NGC85_03330	COG2207	Transcriptional regulator
NGC85_03335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NGC85_03350	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NGC85_03365	COG0183	Belongs to the thiolase family
NGC85_03375	COG2885	chlorophyll binding
NGC85_03375	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NGC85_03385	COG1690	Belongs to the RtcB family
NGC85_03390	COG0833	amino acid
NGC85_03400	COG2233	PERMEase
NGC85_03405	COG1217	gtp-binding protein TYPA
NGC85_03435	COG4772	TonB-dependent receptor
NGC85_03460	COG0354	folic acid binding
NGC85_03475	COG3293	Transposase
NGC85_03480	COG2824	Alkylphosphonate utilization operon protein PhnA
NGC85_03485	COG3422	double-strand break repair
NGC85_03515	COG0840	transmembrane signaling receptor activity
NGC85_03530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NGC85_03535	COG5510	response to toxic substance
NGC85_03545	COG2832	Protein of unknown function (DUF454)
NGC85_03550	COG1376	ErfK ybiS ycfS ynhG family protein
NGC85_03605	COG1289	transmembrane transporter activity
NGC85_03610	COG2814	Major facilitator Superfamily
NGC85_03625	COG0786	glutamate:sodium symporter activity
NGC85_03630	COG1115	amino acid carrier protein
NGC85_03635	COG1752	Esterase of the alpha-beta hydrolase superfamily
NGC85_03640	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
NGC85_03695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NGC85_03705	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NGC85_03710	COG1077	Cell shape determining protein MreB Mrl
NGC85_03715	COG1792	Involved in formation and maintenance of cell shape
NGC85_03725	COG0424	maF-like protein
NGC85_03730	COG1530	ribonuclease E activity
NGC85_03740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NGC85_03750	COG0560	Phosphoserine phosphatase
NGC85_03765	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NGC85_03770	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NGC85_03775	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NGC85_03780	COG2205	protein histidine kinase activity
NGC85_03785	COG0745	RESPONSE REGULATOR receiver
NGC85_03795	COG2851	Citrate transporter
NGC85_03805	COG0671	phosphoesterase, PA-phosphatase related
NGC85_03810	COG0531	amino acid
NGC85_03820	COG0174	glutamine synthetase
NGC85_03905	COG1113	amino acid transport
NGC85_03910	COG2828	Protein conserved in bacteria
NGC85_03915	COG0142	geranyltranstransferase activity
NGC85_03920	COG2315	Protein conserved in bacteria
NGC85_03935	COG1752	Esterase of the alpha-beta hydrolase superfamily
NGC85_03945	COG2814	Major facilitator Superfamily
NGC85_03955	COG2194	sulfuric ester hydrolase activity
NGC85_03960	COG0745	RESPONSE REGULATOR receiver
NGC85_03965	COG0642	Histidine kinase
NGC85_03980	COG0004	ammonium transporteR
NGC85_03990	COG2852	Protein conserved in bacteria
NGC85_04000	COG3293	Transposase
NGC85_04005	COG0525	valine-tRNA ligase activity
NGC85_04020	COG1028	Short-chain dehydrogenase reductase Sdr
NGC85_04030	COG0393	Putative heavy-metal-binding
NGC85_04035	COG0393	Putative heavy-metal-binding
NGC85_04040	COG1538	Outer membrane efflux protein
NGC85_04050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NGC85_04055	COG0671	phosphoesterase, PA-phosphatase related
NGC85_04070	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NGC85_04085	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NGC85_04100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NGC85_04100	COG1648	precorrin-2 dehydrogenase activity
NGC85_04105	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NGC85_04110	COG1733	regulation of RNA biosynthetic process
NGC85_04120	COG0531	amino acid
NGC85_04135	COG0321	lipoyl(octanoyl) transferase activity
NGC85_04145	COG2921	Belongs to the UPF0250 family
NGC85_04165	COG1280	lysine exporter protein (LysE YggA)
NGC85_04170	COG0583	DNA-binding transcription factor activity
NGC85_04175	COG0500	methyltransferase
NGC85_04180	COG0586	Pfam SNARE associated Golgi protein
NGC85_04185	COG1054	Belongs to the UPF0176 family
NGC85_04215	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NGC85_04220	COG1053	succinate dehydrogenase
NGC85_04225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NGC85_04245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NGC85_04260	COG3293	Transposase
NGC85_04265	COG2268	Band 7 protein
NGC85_04270	COG1585	Membrane protein implicated in regulation of membrane protease activity
NGC85_04280	COG2354	Protein conserved in bacteria
NGC85_04285	COG2321	neutral zinc metallopeptidase
NGC85_04325	COG0589	response to stress
NGC85_04345	COG0505	Belongs to the CarA family
NGC85_04370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NGC85_04380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NGC85_04390	COG2304	oxidoreductase activity
NGC85_04415	COG0584	glycerophosphoryl diester phosphodiesterase
NGC85_04430	COG2239	Acts as a magnesium transporter
NGC85_04440	COG0501	Belongs to the peptidase M48B family
NGC85_04445	COG0739	heme binding
NGC85_04445	COG0741	lytic transglycosylase activity
NGC85_04445	COG1196	nuclear chromosome segregation
NGC85_04460	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NGC85_04515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NGC85_04615	COG3210	domain, Protein
NGC85_04645	COG1301	dicarboxylic acid transport
NGC85_04650	COG0583	DNA-binding transcription factor activity
NGC85_04665	COG1607	acyl-coa hydrolase
NGC85_04675	COG0523	cobalamin synthesis protein
NGC85_04680	COG4681	YaeQ
NGC85_04695	COG0726	polysaccharide deacetylase
NGC85_04695	COG1649	PFAM Uncharacterised BCR, COG1649
NGC85_04700	COG1215	transferase activity, transferring glycosyl groups
NGC85_04735	COG2264	protein methyltransferase activity
NGC85_04740	COG2388	GCN5-related N-acetyl-transferase
NGC85_04750	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NGC85_04770	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NGC85_04775	COG1597	lipid kinase activity
NGC85_04820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NGC85_04875	COG4181	ATPase activity
NGC85_04880	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NGC85_04885	COG0457	Tetratricopeptide repeat
NGC85_04885	COG0705	Rhomboid family
NGC85_04915	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NGC85_04930	COG1215	transferase activity, transferring glycosyl groups
NGC85_04955	COG1252	NADH dehydrogenase
NGC85_04960	COG1686	Belongs to the peptidase S11 family
NGC85_05000	COG3831	ATPase activity
NGC85_05005	COG0714	Associated with various cellular activities
NGC85_05015	COG3552	Protein containing von Willebrand factor type A (VWA) domain
NGC85_05035	COG2217	Heavy metal translocating P-type atpase
NGC85_05070	COG0006	proline dipeptidase activity
NGC85_05090	COG1187	pseudouridine synthase activity
NGC85_05105	COG0384	phenazine biosynthesis protein PhzF
NGC85_05110	COG0612	Peptidase, M16
NGC85_05120	COG0589	response to stress
NGC85_05140	COG0242	peptide deformylase activity
NGC85_05145	COG2066	Belongs to the glutaminase family
NGC85_05155	COG2223	nitrite transmembrane transporter activity
NGC85_05160	COG2852	Protein conserved in bacteria
NGC85_05175	COG0306	phosphate transporter
NGC85_05190	COG1115	amino acid carrier protein
NGC85_05195	COG1113	amino acid transport
NGC85_05205	COG0019	diaminopimelate decarboxylase activity
NGC85_05210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NGC85_05215	COG1280	lysine exporter protein (LysE YggA)
NGC85_05270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NGC85_05290	COG1671	Belongs to the UPF0178 family
NGC85_05305	COG4591	ABC-type transport system involved in lipoprotein release permease component
NGC85_05310	COG1136	(ABC) transporter
NGC85_05315	COG0658	competence protein
NGC85_05315	COG2333	competence protein COMEC
NGC85_05325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NGC85_05325	COG0616	signal peptide processing
NGC85_05335	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NGC85_05345	COG0628	permease
NGC85_05350	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NGC85_05385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NGC85_05405	COG0823	Involved in the tonB-independent uptake of proteins
NGC85_05425	COG0824	Thioesterase
NGC85_05435	COG2255	four-way junction helicase activity
NGC85_05455	COG0047	phosphoribosylformylglycinamidine synthase activity
NGC85_05455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NGC85_05465	COG2814	Major facilitator Superfamily
NGC85_05485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NGC85_05485	COG3323	Protein of unknown function (DUF1653)
NGC85_05490	COG0778	Nitroreductase
NGC85_05495	COG1024	Enoyl-CoA hydratase
NGC85_05500	COG1051	belongs to the nudix hydrolase family
NGC85_05500	COG1056	cytidyltransferase-related domain
NGC85_05510	COG0625	glutathione transferase activity
NGC85_05515	COG1942	4-Oxalocrotonate Tautomerase
NGC85_05535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NGC85_05550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NGC85_05555	COG0602	queuosine metabolic process
NGC85_05570	COG0583	DNA-binding transcription factor activity
NGC85_05575	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NGC85_05580	COG4208	sulfate ABC transporter
NGC85_05585	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NGC85_05595	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NGC85_05600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NGC85_05605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NGC85_05620	COG3293	Transposase
NGC85_05630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NGC85_05770	COG5410	chromosome segregation
NGC85_05970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NGC85_05980	COG0481	GTPase activity
NGC85_05995	COG0571	ribonuclease III activity
NGC85_06000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NGC85_06015	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NGC85_06040	COG0436	Aminotransferase
NGC85_06055	COG3706	GGDEF domain
NGC85_06060	COG0556	nucleotide-excision repair
NGC85_06080	COG1253	flavin adenine dinucleotide binding
NGC85_06095	COG3015	lipoprotein NlpE involved in copper resistance
NGC85_06110	COG0517	IMP dehydrogenase activity
NGC85_06110	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NGC85_06115	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NGC85_06125	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NGC85_06130	COG1137	ATPase activity
NGC85_06135	COG1538	Outer membrane efflux protein
NGC85_06165	COG4122	O-methyltransferase activity
NGC85_06175	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NGC85_06215	COG0438	transferase activity, transferring glycosyl groups
NGC85_06245	COG3293	Transposase
NGC85_06255	COG2252	PERMEase
NGC85_06260	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NGC85_06265	COG3038	cytochrome b561
NGC85_06275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NGC85_06295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NGC85_06315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NGC85_06330	COG2308	Evidence 4 Homologs of previously reported genes of
NGC85_06340	COG1305	Transglutaminase-like
NGC85_06355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NGC85_06360	COG0305	Participates in initiation and elongation during chromosome replication
NGC85_06385	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NGC85_06390	COG1845	cytochrome c oxidase, subunit III
NGC85_06395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NGC85_06400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NGC85_06420	COG3300	MHYT domain
NGC85_06420	COG5001	Diguanylate cyclase
NGC85_06425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NGC85_06455	COG0802	atpase or kinase
NGC85_06460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NGC85_06470	COG1923	regulation of RNA biosynthetic process
NGC85_06475	COG0697	spore germination
NGC85_06485	COG2249	NAD(P)H dehydrogenase (quinone) activity
NGC85_06495	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NGC85_06505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NGC85_06510	COG1595	DNA-templated transcription, initiation
NGC85_06555	COG0300	oxidoreductase activity
NGC85_06560	COG2072	flavoprotein involved in K transport
NGC85_06570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NGC85_06620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NGC85_06630	COG4106	trans-aconitate 2-methyltransferase activity
NGC85_06635	COG0642	Histidine kinase
NGC85_06640	COG0745	RESPONSE REGULATOR receiver
NGC85_06660	COG1414	Transcriptional regulator
NGC85_06665	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NGC85_06670	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NGC85_06675	COG0183	Belongs to the thiolase family
NGC85_06680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NGC85_06685	COG0596	Alpha beta hydrolase
NGC85_06690	COG2271	Major facilitator Superfamily
NGC85_06695	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NGC85_06700	COG3485	protocatechuate 3,4-dioxygenase
NGC85_06705	COG3485	protocatechuate 3,4-dioxygenase
NGC85_06710	COG0710	3-dehydroquinate dehydratase activity
NGC85_06715	COG3420	alginic acid biosynthetic process
NGC85_06720	COG3659	wide pore channel activity
NGC85_06725	COG4993	Dehydrogenase
NGC85_06740	COG2351	hydroxyisourate hydrolase activity
NGC85_06745	COG2233	PERMEase
NGC85_06755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NGC85_06765	COG4266	Belongs to the allantoicase family
NGC85_06780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NGC85_06790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NGC85_06805	COG0583	DNA-binding transcription factor activity
NGC85_06815	COG2188	Transcriptional regulator
NGC85_06845	COG0010	Belongs to the arginase family
NGC85_06850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NGC85_06855	COG1028	Short-chain dehydrogenase reductase Sdr
NGC85_06875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NGC85_06915	COG0243	molybdopterin cofactor binding
NGC85_06920	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NGC85_06925	COG2837	iron assimilation
NGC85_06935	COG1538	Outer membrane efflux protein
NGC85_06940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NGC85_06945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NGC85_06950	COG0745	RESPONSE REGULATOR receiver
NGC85_06955	COG5002	protein histidine kinase activity
NGC85_06995	COG1309	transcriptional regulator
NGC85_07015	COG2072	flavoprotein involved in K transport
NGC85_07020	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NGC85_07035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NGC85_07040	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NGC85_07045	COG1984	allophanate hydrolase subunit 2
NGC85_07050	COG4770	biotin carboxylase activity
NGC85_07055	COG0501	Belongs to the peptidase M48B family
NGC85_07065	COG1765	OsmC-like protein
NGC85_07135	COG1278	Cold shock
NGC85_07140	COG1278	Cold shock
NGC85_07160	COG3042	response to heat
NGC85_07180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NGC85_07185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NGC85_07205	COG2353	YceI-like domain
NGC85_07215	COG3811	Belongs to the UPF0386 family
NGC85_07235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NGC85_07240	COG0506	proline dehydrogenase activity
NGC85_07240	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NGC85_07240	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NGC85_07250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NGC85_07265	COG2030	dehydratase
NGC85_07270	COG1132	(ABC) transporter
NGC85_07290	COG0668	transmembrane transport
NGC85_07295	COG3122	Protein conserved in bacteria
NGC85_07315	COG0640	Transcriptional regulator
NGC85_07335	COG2850	peptidyl-arginine hydroxylation
NGC85_07340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NGC85_07380	COG1358	cellular component organization or biogenesis
NGC85_07425	COG0824	Thioesterase
NGC85_07430	COG1454	alcohol dehydrogenase
NGC85_07435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NGC85_07455	COG0069	glutamate synthase activity
NGC85_07475	COG0625	glutathione transferase activity
NGC85_07485	COG1113	amino acid transport
NGC85_07490	COG2814	Major facilitator Superfamily
NGC85_07505	COG0439	Biotin carboxylase
NGC85_07510	COG0511	ligase activity, forming carbon-carbon bonds
NGC85_07520	COG1116	anion transmembrane transporter activity
NGC85_07520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NGC85_07530	COG2223	nitrite transmembrane transporter activity
NGC85_07535	COG2146	nitrite reductase [NAD(P)H] activity
NGC85_07535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NGC85_07540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NGC85_07545	COG0243	molybdopterin cofactor binding
NGC85_07555	COG3293	Transposase
NGC85_07565	COG0243	molybdopterin cofactor binding
NGC85_07570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NGC85_07585	COG0315	cyclic pyranopterin monophosphate synthase activity
NGC85_07585	COG0521	Mo-molybdopterin cofactor biosynthetic process
NGC85_07590	COG0303	'Molybdopterin
NGC85_07600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NGC85_07605	COG0697	spore germination
NGC85_07625	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NGC85_07630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NGC85_07710	COG0024	Methionine aminopeptidase
NGC85_07715	COG0583	DNA-binding transcription factor activity
NGC85_07720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NGC85_07730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NGC85_07735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NGC85_07740	COG0517	IMP dehydrogenase activity
NGC85_07765	COG0552	protein localization to endoplasmic reticulum
NGC85_07790	COG4890	Cyd operon protein YbgT
NGC85_07795	COG1294	oxidase, subunit
NGC85_07820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NGC85_07845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NGC85_07850	COG0569	domain protein
NGC85_07855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NGC85_07885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NGC85_07895	COG0542	response to heat
NGC85_07905	COG0488	(ABC) transporter
NGC85_07910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NGC85_07915	COG2267	carboxylic ester hydrolase activity
NGC85_07925	COG0446	pyridine nucleotide-disulphide oxidoreductase
NGC85_07925	COG1902	pentaerythritol trinitrate reductase activity
NGC85_07960	COG0148	phosphopyruvate hydratase activity
NGC85_07965	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NGC85_08035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NGC85_08040	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NGC85_08060	COG1802	Transcriptional regulator
NGC85_08070	COG2207	Transcriptional regulator
NGC85_08075	COG1063	alcohol dehydrogenase
NGC85_08085	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NGC85_08135	COG1944	ATP diphosphatase activity
NGC85_08145	COG4221	oxidoreductase activity
NGC85_08150	COG4771	TonB-dependent receptor
NGC85_08180	COG1595	DNA-templated transcription, initiation
NGC85_08230	COG4689	acetoacetate decarboxylase
NGC85_08240	COG0446	pyridine nucleotide-disulphide oxidoreductase
NGC85_08240	COG1902	pentaerythritol trinitrate reductase activity
NGC85_08250	COG0583	DNA-binding transcription factor activity
NGC85_08260	COG4770	biotin carboxylase activity
NGC85_08265	COG1024	Enoyl-CoA hydratase
NGC85_08270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NGC85_08275	COG1960	acyl-CoA dehydrogenase activity
NGC85_08280	COG1309	transcriptional regulator
NGC85_08285	COG0318	PFAM AMP-dependent synthetase and ligase
NGC85_08300	COG2814	Major facilitator Superfamily
NGC85_08320	COG0583	DNA-binding transcription factor activity
NGC85_08345	COG4628	conserved protein (DUF2132)
NGC85_08420	COG2249	NAD(P)H dehydrogenase (quinone) activity
NGC85_08430	COG3706	GGDEF domain
NGC85_08450	COG0133	tryptophan synthase activity
NGC85_08460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NGC85_08475	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NGC85_08480	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NGC85_08520	COG0537	adenosine 5'-monophosphoramidase activity
NGC85_08545	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NGC85_08565	COG0730	response to heat
NGC85_08580	COG4772	TonB-dependent receptor
NGC85_08605	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NGC85_08620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NGC85_08635	COG2223	nitrite transmembrane transporter activity
NGC85_08665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NGC85_08680	COG1960	acyl-CoA dehydrogenase activity
NGC85_08685	COG1960	acyl-CoA dehydrogenase activity
NGC85_08690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NGC85_08695	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NGC85_08700	COG2207	Transcriptional regulator
NGC85_08705	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NGC85_08725	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NGC85_08740	COG0575	Belongs to the CDS family
NGC85_08745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NGC85_08750	COG0233	cytoplasmic translational termination
NGC85_08755	COG0528	UMP kinase activity
NGC85_08765	COG3852	Histidine kinase
NGC85_08770	COG2204	response regulator
NGC85_08780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NGC85_08785	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NGC85_08800	COG2431	L-lysine efflux transmembrane transporter activity
NGC85_08830	COG0776	regulation of translation
NGC85_08895	COG0084	hydrolase, TatD family'
NGC85_08925	COG1663	tetraacyldisaccharide 4'-kinase activity
NGC85_08930	COG1132	(ABC) transporter
NGC85_08940	COG0811	peptide transport
NGC85_08945	COG1475	DNA binding
NGC85_08950	COG1192	Involved in chromosome partitioning
NGC85_08960	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NGC85_08975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NGC85_08985	COG0513	Belongs to the DEAD box helicase family
NGC85_09005	COG2363	Small membrane protein
NGC85_09025	COG3293	Transposase
NGC85_09055	COG4650	regulator
NGC85_09065	COG1234	tRNA 3'-trailer cleavage
NGC85_09070	COG1690	Belongs to the RtcB family
NGC85_09090	COG2195	Cleaves the N-terminal amino acid of tripeptides
NGC85_09100	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NGC85_09120	COG1960	acyl-CoA dehydrogenase activity
NGC85_09150	COG3139	Protein of unknown function (DUF1315)
NGC85_09155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NGC85_09160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NGC85_09170	COG0494	nUDIX hydrolase
NGC85_09180	COG0642	Histidine kinase
NGC85_09195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NGC85_09200	COG1720	tRNA m6t6A37 methyltransferase activity
NGC85_09235	COG0583	DNA-binding transcription factor activity
NGC85_09240	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NGC85_09250	COG2814	Major facilitator Superfamily
NGC85_09255	COG3647	Membrane
NGC85_09260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NGC85_09265	COG0471	metal ion transport
NGC85_09295	COG0729	surface antigen
NGC85_09300	COG0477	Major facilitator Superfamily
NGC85_09325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NGC85_09335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NGC85_09345	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NGC85_09355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NGC85_09360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NGC85_09375	COG2808	Putative FMN-binding domain
NGC85_09390	COG4682	membrane
NGC85_09400	COG0826	peptidase U32
NGC85_09405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NGC85_09415	COG1116	anion transmembrane transporter activity
NGC85_09435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NGC85_09440	COG0864	Transcriptional regulator
NGC85_09445	COG4770	biotin carboxylase activity
NGC85_09485	COG1131	(ABC) transporter
NGC85_09490	COG0842	Transport permease protein
NGC85_09505	COG0772	Belongs to the SEDS family
NGC85_09510	COG2951	lytic endotransglycosylase activity
NGC85_09535	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NGC85_09550	COG1643	Atp-dependent helicase
NGC85_09570	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NGC85_09590	COG3634	alkyl hydroperoxide reductase activity
NGC85_09610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NGC85_09665	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NGC85_09665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NGC85_09690	COG3539	Fimbrial protein
NGC85_09720	COG0753	catalase activity
NGC85_09725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NGC85_09735	COG0753	catalase activity
NGC85_09740	COG1560	Kdo2-lipid A biosynthetic process
NGC85_09780	COG1464	Belongs to the NlpA lipoprotein family
NGC85_09785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NGC85_09790	COG2011	ABC-type metal ion transport system permease component
NGC85_09795	COG0012	GTP binding
NGC85_09810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NGC85_09815	COG1253	flavin adenine dinucleotide binding
NGC85_09825	COG3293	Transposase
NGC85_09830	COG1942	4-Oxalocrotonate Tautomerase
NGC85_09880	COG0386	Belongs to the glutathione peroxidase family
NGC85_09890	COG0436	Aminotransferase
NGC85_09915	COG1045	serine acetyltransferase
NGC85_09930	COG3634	alkyl hydroperoxide reductase activity
NGC85_09985	COG1286	toxin biosynthetic process
NGC85_10020	COG4585	Histidine kinase
NGC85_10045	COG0778	Nitroreductase
NGC85_10070	COG0424	maF-like protein
NGC85_10100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NGC85_10115	COG0183	Belongs to the thiolase family
NGC85_10130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NGC85_10135	COG0702	epimerase
NGC85_10140	COG0268	Binds directly to 16S ribosomal RNA
NGC85_10160	COG1218	3'(2'),5'-bisphosphate nucleotidase
NGC85_10165	COG1011	Hydrolase
NGC85_10170	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NGC85_10180	COG2137	regulation of response to DNA damage stimulus
NGC85_10195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NGC85_10225	COG0822	iron-sulfur transferase activity
NGC85_10230	COG0316	Belongs to the HesB IscA family
NGC85_10260	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NGC85_10270	COG1045	serine acetyltransferase
NGC85_10275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NGC85_10280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NGC85_10285	COG1280	lysine exporter protein (LysE YggA)
NGC85_10360	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NGC85_10380	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NGC85_10395	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NGC85_10395	COG3008	intermembrane lipid transfer
NGC85_10400	COG2995	paraquat-inducible protein a
NGC85_10445	COG3052	prosthetic group binding
NGC85_10450	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
NGC85_10465	COG0583	DNA-binding transcription factor activity
NGC85_10470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NGC85_10480	COG3135	benzoate transporter
NGC85_10485	COG0475	glutathione-regulated potassium exporter activity
NGC85_10485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NGC85_10500	COG1714	RDD family
NGC85_10510	COG1760	l-serine dehydratase
NGC85_10515	COG0308	aminopeptidase N
NGC85_10560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NGC85_10570	COG0531	amino acid
NGC85_10575	COG4303	Ethanolamine ammonia lyase large subunit
NGC85_10580	COG4302	ethanolamine ammonia-lyase activity
NGC85_10590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NGC85_10590	COG0519	Catalyzes the synthesis of GMP from XMP
NGC85_10630	COG1028	Short-chain dehydrogenase reductase Sdr
NGC85_10635	COG4221	oxidoreductase activity
NGC85_10635	COG0604	alcohol dehydrogenase
NGC85_10635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NGC85_10635	COG3321	synthase
NGC85_10640	COG0667	Aldo Keto reductase
NGC85_10655	COG0582	viral genome integration into host DNA
NGC85_10665	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NGC85_10715	COG2132	Multicopper oxidase
NGC85_10730	COG2205	protein histidine kinase activity
NGC85_10735	COG2217	Heavy metal translocating P-type atpase
NGC85_10795	COG3311	Transcriptional regulator
NGC85_10810	COG1902	pentaerythritol trinitrate reductase activity
NGC85_10810	COG0446	pyridine nucleotide-disulphide oxidoreductase
NGC85_10820	COG1741	Belongs to the pirin family
NGC85_10910	COG0714	Associated with various cellular activities
NGC85_10915	COG2879	small protein
NGC85_10920	COG1966	Carbon starvation protein
NGC85_10925	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NGC85_10945	COG0254	rRNA binding
NGC85_10965	COG1067	ATP-dependent peptidase activity
NGC85_10970	COG0583	DNA-binding transcription factor activity
NGC85_10980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NGC85_11000	COG1686	Belongs to the peptidase S11 family
NGC85_11005	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NGC85_11020	COG0482	sulfurtransferase activity
NGC85_11040	COG0028	Belongs to the TPP enzyme family
NGC85_11055	COG1028	Short-chain dehydrogenase reductase Sdr
NGC85_11070	COG2271	Major facilitator Superfamily
NGC85_11085	COG1028	Short-chain dehydrogenase reductase Sdr
NGC85_11105	COG1414	Transcriptional regulator
NGC85_11110	COG0523	cobalamin synthesis protein
NGC85_11125	COG1469	GTP cyclohydrolase I activity
NGC85_11130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NGC85_11135	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NGC85_11135	COG4451	ribulose bisphosphate carboxylase, small
NGC85_11140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NGC85_11195	COG1271	oxidase subunit
NGC85_11200	COG1294	oxidase, subunit
NGC85_11295	COG1610	YqeY-like protein
NGC85_11310	COG4783	chaperone-mediated protein folding
NGC85_11365	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NGC85_11370	COG0138	bifunctional purine biosynthesis protein purh
NGC85_11380	COG1464	Belongs to the NlpA lipoprotein family
NGC85_11385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NGC85_11390	COG2011	ABC-type metal ion transport system permease component
NGC85_11415	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NGC85_11420	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NGC85_11425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NGC85_11435	COG0280	phosphate acetyltransferase
NGC85_11435	COG0281	malic enzyme
NGC85_11450	COG0052	Belongs to the universal ribosomal protein uS2 family
NGC85_11455	COG0024	Methionine aminopeptidase
NGC85_11465	COG2223	nitrite transmembrane transporter activity
NGC85_11475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NGC85_11480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NGC85_11485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NGC85_11520	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NGC85_11525	COG3161	chorismate lyase activity
NGC85_11530	COG0174	glutamine synthetase
NGC85_11535	COG0512	Glutamine amidotransferase of anthranilate synthase
NGC85_11540	COG1823	symporter activity
NGC85_11545	COG3217	Mosc domain protein beta barrel domain protein
NGC85_11545	COG0633	Ferredoxin
NGC85_11570	COG0302	gtp cyclohydrolase
NGC85_11595	COG3739	integral membrane protein
NGC85_11610	COG3706	GGDEF domain
NGC85_11610	COG4251	negative regulation of phosphorylation
NGC85_11610	COG5001	Diguanylate cyclase
NGC85_11610	COG2203	Gaf domain
NGC85_11620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NGC85_11630	COG0222	ribosome binding
NGC85_11650	COG0175	sulfate reduction
NGC85_11660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NGC85_11670	COG1773	rubredoxin
NGC85_11675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NGC85_11680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NGC85_11685	COG0583	DNA-binding transcription factor activity
NGC85_11710	COG4172	Belongs to the ABC transporter superfamily
NGC85_11715	COG4239	(ABC) transporter, permease
NGC85_11720	COG4174	ABC transporter (Permease)
NGC85_11725	COG4166	transmembrane transport
NGC85_11730	COG0741	lytic transglycosylase activity
NGC85_11730	COG1388	LysM domain
NGC85_11775	COG0583	DNA-binding transcription factor activity
NGC85_11790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NGC85_11795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NGC85_11800	COG3293	Transposase
NGC85_11805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NGC85_11820	COG3384	dioxygenase
NGC85_11830	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NGC85_11835	COG2878	Part of a membrane complex involved in electron transport
NGC85_11840	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NGC85_11865	COG0768	penicillin binding
NGC85_11870	COG0742	ribosomal rna small subunit methyltransferase
NGC85_11890	COG3647	Membrane
NGC85_11900	COG0616	signal peptide processing
NGC85_11905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NGC85_11915	COG0573	inorganic phosphate transmembrane transporter activity
NGC85_11925	COG3293	Transposase
NGC85_11935	COG0076	glutamate decarboxylase activity
NGC85_11940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NGC85_11975	COG1309	transcriptional regulator
NGC85_11985	COG0783	Belongs to the Dps family
NGC85_11995	COG0564	pseudouridine synthase activity
NGC85_12010	COG0352	thiamine-phosphate diphosphorylase activity
NGC85_12020	COG3025	triphosphatase activity
NGC85_12055	COG2175	clavaminate synthase activity
NGC85_12060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NGC85_12065	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NGC85_12070	COG4521	taurine ABC transporter
NGC85_12080	COG1230	cation diffusion facilitator family transporter
NGC85_12095	COG4149	molybdate abc transporter
NGC85_12100	COG0725	ABC transporter, periplasmic molybdate-binding protein
NGC85_12195	COG3046	protein related to deoxyribodipyrimidine photolyase
NGC85_12205	COG3040	lipid binding
NGC85_12210	COG1454	alcohol dehydrogenase
NGC85_12235	COG0625	glutathione transferase activity
NGC85_12280	COG2814	Major facilitator Superfamily
NGC85_12285	COG1566	PFAM secretion protein HlyD family protein
NGC85_12290	COG2050	protein possibly involved in aromatic compounds catabolism
NGC85_12300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NGC85_12305	COG1090	epimerase
NGC85_12335	COG0420	3'-5' exonuclease activity
NGC85_12380	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NGC85_12385	COG2914	Belongs to the UPF0125 (RnfH) family
NGC85_12400	COG0121	glutamine amidotransferase
NGC85_12420	COG0756	dUTP diphosphatase activity
NGC85_12425	COG0210	DNA helicase
NGC85_12430	COG2885	chlorophyll binding
NGC85_12435	COG0204	Acyl-transferase
NGC85_12445	COG0850	regulation of cytokinetic process
NGC85_12450	COG2894	cell division
NGC85_12455	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NGC85_12465	COG0531	amino acid
NGC85_12465	COG1674	ftsk spoiiie
NGC85_12470	COG0492	ferredoxin-NADP+ reductase activity
NGC85_12475	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NGC85_12485	COG0456	acetyltransferase
NGC85_12505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NGC85_12510	COG0049	tRNA binding
NGC85_12530	COG1981	membrane
NGC85_12545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NGC85_12545	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NGC85_12570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NGC85_12580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NGC85_12595	COG0564	pseudouridine synthase activity
NGC85_12620	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NGC85_12650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NGC85_12685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NGC85_12695	COG0351	phosphomethylpyrimidine kinase
NGC85_12695	COG0352	thiamine-phosphate diphosphorylase activity
NGC85_12695	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NGC85_12700	COG1652	LysM domain
NGC85_12710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NGC85_12730	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NGC85_12735	COG1399	metal-binding, possibly nucleic acid-binding protein
NGC85_12740	COG3101	peptidyl-lysine hydroxylation
NGC85_12745	COG0009	L-threonylcarbamoyladenylate synthase
NGC85_12755	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NGC85_12760	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NGC85_12765	COG1187	pseudouridine synthase activity
NGC85_12790	COG0747	negative chemotaxis
NGC85_12795	COG4166	transmembrane transport
NGC85_12840	COG4106	trans-aconitate 2-methyltransferase activity
NGC85_12855	COG0596	Alpha beta hydrolase
NGC85_12855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NGC85_12855	COG2226	methyltransferase
NGC85_12860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NGC85_12865	COG3293	Transposase
NGC85_12880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NGC85_12890	COG1196	nuclear chromosome segregation
NGC85_12910	COG0730	response to heat
NGC85_12930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NGC85_12940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NGC85_12985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NGC85_12990	COG0489	protein tyrosine kinase activity
NGC85_13020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NGC85_13020	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NGC85_13035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NGC85_13045	COG2226	methyltransferase
NGC85_13070	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NGC85_13080	COG2081	HI0933 family
NGC85_13090	COG0668	transmembrane transport
NGC85_13105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NGC85_13110	COG0583	DNA-binding transcription factor activity
NGC85_13115	COG1278	Cold shock
NGC85_13135	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NGC85_13140	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NGC85_13155	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NGC85_13170	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NGC85_13180	COG0649	NAD binding
NGC85_13180	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NGC85_13190	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NGC85_13195	COG3706	GGDEF domain
NGC85_13205	COG2205	protein histidine kinase activity
NGC85_13210	COG0745	RESPONSE REGULATOR receiver
NGC85_13230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NGC85_13260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NGC85_13265	COG1309	transcriptional regulator
NGC85_13285	COG1063	alcohol dehydrogenase
NGC85_13300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NGC85_13350	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NGC85_13355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NGC85_13360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NGC85_13385	COG2132	Multicopper oxidase
NGC85_13395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NGC85_13420	COG1968	undecaprenyl-diphosphatase activity
NGC85_13425	COG1214	PFAM Peptidase M22, glycoprotease
NGC85_13435	COG0494	nUDIX hydrolase
NGC85_13485	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NGC85_13490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NGC85_13495	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NGC85_13545	COG2853	Lipoprotein
NGC85_13560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NGC85_13570	COG1846	Transcriptional regulator
NGC85_13575	COG1764	response to oxidative stress
NGC85_13605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NGC85_13605	COG2755	lipolytic protein G-D-S-L family
NGC85_13620	COG0037	tRNA processing
NGC85_13630	COG0248	Ppx GppA phosphatase
NGC85_13655	COG0072	phenylalanine-tRNA ligase activity
NGC85_13700	COG1238	metal cluster binding
NGC85_13715	COG0625	glutathione transferase activity
NGC85_13735	COG0318	PFAM AMP-dependent synthetase and ligase
NGC85_13740	COG3028	Belongs to the UPF0307 family
NGC85_13765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NGC85_13770	COG0617	tRNA 3'-terminal CCA addition
NGC85_13775	COG1555	photosystem II stabilization
NGC85_13780	COG3956	TIGRFAM MazG family protein
NGC85_13790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NGC85_13810	COG5002	protein histidine kinase activity
NGC85_13810	COG2205	protein histidine kinase activity
NGC85_13810	COG0784	Response regulator, receiver
NGC85_13820	COG2084	Dehydrogenase
NGC85_13825	COG3622	Belongs to the hyi family
NGC85_13840	COG0004	ammonium transporteR
NGC85_13880	COG2814	Major facilitator Superfamily
NGC85_13900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NGC85_13910	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NGC85_13915	COG2814	Major facilitator Superfamily
NGC85_13930	COG0084	hydrolase, TatD family'
NGC85_13935	COG0726	polysaccharide deacetylase
NGC85_13945	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NGC85_13950	COG3293	Transposase
NGC85_13965	COG1473	amidohydrolase
NGC85_14025	COG0431	NADPH-dependent FMN reductase
NGC85_14030	COG0798	PFAM Bile acid sodium symporter
NGC85_14040	COG0640	Transcriptional regulator
NGC85_14065	COG0440	acetolactate synthase activity
NGC85_14070	COG0028	Belongs to the TPP enzyme family
NGC85_14090	COG1466	dna polymerase III delta subunit
NGC85_14095	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NGC85_14100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NGC85_14105	COG0577	efflux transmembrane transporter activity
NGC85_14105	COG1136	(ABC) transporter
NGC85_14110	COG1538	Outer membrane efflux protein
NGC85_14135	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NGC85_14140	COG1162	GTPase activity
NGC85_14150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NGC85_14190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NGC85_14200	COG3781	membrane
NGC85_14210	COG0587	DNA-directed DNA polymerase activity
NGC85_14220	COG2350	Protein conserved in bacteria
NGC85_14240	COG1666	GTP binding
NGC85_14255	COG1956	GAF domain-containing protein
NGC85_14260	COG1607	acyl-coa hydrolase
NGC85_14315	COG1183	phosphatidylcholine synthase activity
NGC85_14320	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NGC85_14350	COG1196	nuclear chromosome segregation
NGC85_14350	COG0741	lytic transglycosylase activity
NGC85_14350	COG0739	heme binding
NGC85_14360	COG1702	phosphate starvation-inducible protein PhoH
NGC85_14375	COG4773	Receptor
NGC85_14440	COG0788	formyltetrahydrofolate deformylase activity
NGC85_14465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NGC85_14465	COG4651	solute:proton antiporter activity
NGC85_14490	COG0724	RNA recognition motif
NGC85_14495	COG0210	DNA helicase
NGC85_14525	COG2900	Belongs to the SlyX family
NGC85_14530	COG0488	(ABC) transporter
NGC85_14540	COG1560	Kdo2-lipid A biosynthetic process
NGC85_14615	COG0473	3-isopropylmalate dehydrogenase activity
NGC85_14645	COG0583	DNA-binding transcription factor activity
NGC85_14670	COG0494	nUDIX hydrolase
NGC85_14685	COG0753	catalase activity
NGC85_14690	COG3011	Protein conserved in bacteria
NGC85_14700	COG0519	Catalyzes the synthesis of GMP from XMP
NGC85_14710	COG0583	DNA-binding transcription factor activity
NGC85_14715	COG0625	glutathione transferase activity
NGC85_14725	COG0546	phosphoglycolate phosphatase activity
NGC85_14740	COG1530	ribonuclease E activity
NGC85_14745	COG0318	PFAM AMP-dependent synthetase and ligase
NGC85_14760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NGC85_14770	COG0534	Mate efflux family protein
NGC85_14775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NGC85_14815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NGC85_14830	COG0493	'glutamate synthase
NGC85_14830	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NGC85_14840	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NGC85_14845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NGC85_14860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NGC85_14875	COG0644	oxidoreductase
NGC85_14875	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
NGC85_14885	COG1595	DNA-templated transcription, initiation
NGC85_14895	COG3220	belongs to the UPF0276 family
NGC85_14910	COG0425	Belongs to the sulfur carrier protein TusA family
NGC85_14915	COG4535	Mg2 and Co2 transporter CorC
NGC85_14940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NGC85_14945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NGC85_14945	COG0475	glutathione-regulated potassium exporter activity
NGC85_14960	COG0789	Transcriptional regulator
NGC85_14965	COG0598	Magnesium transport protein CorA
NGC85_14970	COG1301	dicarboxylic acid transport
NGC85_14975	COG1185	polyribonucleotide nucleotidyltransferase activity
NGC85_14980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NGC85_14985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NGC85_14990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NGC85_14995	COG1074	ATP-dependent DNA helicase activity
NGC85_15000	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NGC85_15020	COG2226	methyltransferase
NGC85_15035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NGC85_15045	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NGC85_15060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NGC85_15060	COG2111	Na H antiporter
NGC85_15065	COG1006	Multisubunit Na H antiporter MnhC subunit
NGC85_15070	COG0651	ATP synthesis coupled electron transport
NGC85_15075	COG1863	multisubunit Na H antiporter MnhE subunit
NGC85_15080	COG2212	antiporter activity
NGC85_15085	COG1320	monovalent cation:proton antiporter activity
NGC85_15090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NGC85_15100	COG0195	Participates in both transcription termination and antitermination
NGC85_15125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NGC85_15150	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NGC85_15155	COG0237	dephospho-CoA kinase activity
NGC85_15165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NGC85_15170	COG3123	guanosine phosphorylase activity
NGC85_15175	COG0497	DNA recombination
NGC85_15185	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NGC85_15215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NGC85_15240	COG3706	GGDEF domain
NGC85_15270	COG1132	(ABC) transporter
NGC85_15280	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NGC85_15305	COG0326	Molecular chaperone. Has ATPase activity
NGC85_15320	COG2056	Na+-H+ antiporter family
NGC85_15355	COG0222	ribosome binding
NGC85_15360	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NGC85_15365	COG0081	regulation of translation
NGC85_15370	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NGC85_15425	COG1716	ATPase activity
NGC85_15470	COG0181	hydroxymethylbilane synthase activity
NGC85_15480	COG3275	phosphorelay sensor kinase activity
NGC85_15520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NGC85_15525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NGC85_15530	COG0772	Belongs to the SEDS family
NGC85_15560	COG4974	Belongs to the 'phage' integrase family
NGC85_15565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NGC85_15575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NGC85_15590	COG2197	response regulator
NGC85_15605	COG0793	Belongs to the peptidase S41A family
NGC85_15610	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NGC85_15615	COG0795	lipopolysaccharide-transporting ATPase activity
NGC85_15620	COG0795	lipopolysaccharide-transporting ATPase activity
NGC85_15655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NGC85_15655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NGC85_15665	COG0004	ammonium transporteR
NGC85_15670	COG0347	Belongs to the P(II) protein family
NGC85_15700	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NGC85_15715	COG0318	PFAM AMP-dependent synthetase and ligase
NGC85_15730	COG2860	membrane
NGC85_15740	COG1253	flavin adenine dinucleotide binding
NGC85_15760	COG2814	Major facilitator Superfamily
NGC85_15775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NGC85_15780	COG0745	RESPONSE REGULATOR receiver
NGC85_15790	COG2205	protein histidine kinase activity
NGC85_15825	COG2814	Major facilitator Superfamily
NGC85_15845	COG0655	NAD(P)H dehydrogenase (quinone) activity
NGC85_15870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NGC85_15905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NGC85_15930	COG3162	membrane
NGC85_15935	COG0784	Response regulator, receiver
NGC85_15935	COG2205	protein histidine kinase activity
NGC85_15960	COG1652	LysM domain
NGC85_15965	COG0758	DNA mediated transformation
NGC85_15985	COG1309	transcriptional regulator
NGC85_16000	COG0386	Belongs to the glutathione peroxidase family
NGC85_16025	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NGC85_16030	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NGC85_16035	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NGC85_16075	COG1121	(ABC) transporter
NGC85_16080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NGC85_16090	COG2837	iron assimilation
NGC85_16095	COG0281	malic enzyme
NGC85_16135	COG0735	belongs to the Fur family
NGC85_16145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NGC85_16160	COG3676	manually curated
NGC85_16170	COG0519	Catalyzes the synthesis of GMP from XMP
NGC85_16170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NGC85_16180	COG3111	PFAM Bacterial OB fold (BOF) protein
NGC85_16185	COG2259	Doxx family
NGC85_16190	COG0586	Pfam SNARE associated Golgi protein
NGC85_16205	COG1192	Involved in chromosome partitioning
NGC85_16215	COG0271	Belongs to the BolA IbaG family
NGC85_16230	COG0477	Major facilitator Superfamily
NGC85_16235	COG1024	Enoyl-CoA hydratase
NGC85_16240	COG1024	Enoyl-CoA hydratase
NGC85_16245	COG1960	acyl-CoA dehydrogenase activity
NGC85_16250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NGC85_16270	COG1113	amino acid transport
NGC85_16275	COG0251	oxidation-reduction process
NGC85_16315	COG0564	pseudouridine synthase activity
NGC85_16330	COG3293	Transposase
NGC85_16390	COG1802	Transcriptional regulator
NGC85_16395	COG1448	Aminotransferase
NGC85_16400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NGC85_16405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NGC85_16420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NGC85_16430	COG0110	maltose O-acetyltransferase activity
NGC85_16435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NGC85_16445	COG1215	transferase activity, transferring glycosyl groups
NGC85_16465	COG2244	polysaccharide biosynthetic process
NGC85_16470	COG1083	cytidylyl-transferase
NGC85_16475	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NGC85_16480	COG1045	serine acetyltransferase
NGC85_16485	COG2089	acid synthase
NGC85_16490	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NGC85_16495	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NGC85_16535	COG3023	N-Acetylmuramoyl-L-alanine amidase
NGC85_16590	COG0546	phosphoglycolate phosphatase activity
NGC85_16595	COG1028	Short-chain dehydrogenase reductase Sdr
NGC85_16605	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NGC85_16605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NGC85_16610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NGC85_16615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NGC85_16620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NGC85_16625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NGC85_16630	COG1116	anion transmembrane transporter activity
NGC85_16635	COG1309	transcriptional regulator
NGC85_16645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NGC85_16655	COG0196	riboflavin kinase activity
NGC85_16660	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NGC85_16670	COG1047	Peptidyl-prolyl cis-trans
NGC85_16710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NGC85_16715	COG0657	acetylesterase activity
NGC85_16730	COG0583	DNA-binding transcription factor activity
NGC85_16745	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NGC85_16775	COG2951	lytic endotransglycosylase activity
NGC85_16780	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NGC85_16800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NGC85_16825	COG0583	DNA-binding transcription factor activity
NGC85_16835	COG0861	Integral membrane protein TerC family
NGC85_16845	COG0402	S-adenosylhomocysteine deaminase activity
NGC85_16870	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
NGC85_16880	COG0706	membrane insertase activity
NGC85_17060	COG0501	Belongs to the peptidase M48B family
NGC85_17065	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NGC85_17095	COG4974	Belongs to the 'phage' integrase family
NGC85_17125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NGC85_17190	COG1525	nuclease
NGC85_17315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NGC85_17395	COG0739	heme binding