locus-tag	class	description
GFH30_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GFH30_00010	COG0592	DNA-directed DNA polymerase activity
GFH30_00020	COG0187	DNA topoisomerase II activity
GFH30_00030	COG1063	alcohol dehydrogenase
GFH30_00035	COG0488	(ABC) transporter
GFH30_00095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GFH30_00130	COG2203	Gaf domain
GFH30_00130	COG4251	negative regulation of phosphorylation
GFH30_00130	COG5001	Diguanylate cyclase
GFH30_00130	COG3706	GGDEF domain
GFH30_00135	COG2133	pyrroloquinoline quinone binding
GFH30_00145	COG1047	Peptidyl-prolyl cis-trans
GFH30_00150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GFH30_00155	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GFH30_00160	COG0196	riboflavin kinase activity
GFH30_00175	COG1309	transcriptional regulator
GFH30_00180	COG1116	anion transmembrane transporter activity
GFH30_00185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFH30_00190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH30_00195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GFH30_00200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GFH30_00225	COG1028	Short-chain dehydrogenase reductase Sdr
GFH30_00230	COG0546	phosphoglycolate phosphatase activity
GFH30_00235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GFH30_00250	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GFH30_00265	COG3023	N-Acetylmuramoyl-L-alanine amidase
GFH30_00275	COG5487	UPF0391 membrane protein
GFH30_00280	COG2983	Belongs to the UPF0260 family
GFH30_00285	COG3300	MHYT domain
GFH30_00285	COG5001	Diguanylate cyclase
GFH30_00290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GFH30_00295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GFH30_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFH30_00310	COG2814	Major facilitator Superfamily
GFH30_00315	COG1335	isochorismatase
GFH30_00320	COG0385	Bile acid
GFH30_00330	COG0560	Phosphoserine phosphatase
GFH30_00330	COG3830	Belongs to the UPF0237 family
GFH30_00390	COG2733	membrane
GFH30_00405	COG2918	glutathione biosynthetic process
GFH30_00420	COG3150	esterase
GFH30_00445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFH30_00450	COG0410	ABC transporter
GFH30_00475	COG2205	protein histidine kinase activity
GFH30_00475	COG0784	Response regulator, receiver
GFH30_00480	COG3706	GGDEF domain
GFH30_00480	COG0745	RESPONSE REGULATOR receiver
GFH30_00535	COG1393	Belongs to the ArsC family
GFH30_00540	COG0708	Exodeoxyribonuclease III
GFH30_00570	COG1278	Cold shock
GFH30_00580	COG0189	ligase activity
GFH30_00600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GFH30_00610	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GFH30_00645	COG2119	membrane
GFH30_00650	COG0426	domain, Protein
GFH30_00650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFH30_00680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GFH30_00700	COG0640	Transcriptional regulator
GFH30_00705	COG1902	pentaerythritol trinitrate reductase activity
GFH30_00710	COG1519	Transferase
GFH30_00715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GFH30_00720	COG0668	transmembrane transport
GFH30_00725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFH30_00740	COG0307	riboflavin synthase, alpha
GFH30_00750	COG0431	NADPH-dependent FMN reductase
GFH30_00765	COG2205	protein histidine kinase activity
GFH30_00765	COG0784	Response regulator, receiver
GFH30_00770	COG3162	membrane
GFH30_00785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GFH30_00795	COG3706	GGDEF domain
GFH30_00820	COG2814	Major facilitator Superfamily
GFH30_00825	COG0629	single-stranded DNA binding
GFH30_00830	COG0450	alkyl hydroperoxide reductase
GFH30_00840	COG1335	isochorismatase
GFH30_00850	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
GFH30_00895	COG0582	viral genome integration into host DNA
GFH30_00905	COG1570	exodeoxyribonuclease VII activity
GFH30_00980	COG0305	Participates in initiation and elongation during chromosome replication
GFH30_01000	COG3646	Phage regulatory protein
GFH30_01015	COG0582	viral genome integration into host DNA
GFH30_01025	COG3158	transport of potassium into the cell
GFH30_01055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GFH30_01070	COG0697	spore germination
GFH30_01090	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GFH30_01095	COG0131	Imidazoleglycerol-phosphate dehydratase
GFH30_01150	COG1024	Enoyl-CoA hydratase
GFH30_01150	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFH30_01155	COG3706	GGDEF domain
GFH30_01180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GFH30_01190	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GFH30_01195	COG0165	Argininosuccinate lyase
GFH30_01200	COG3275	phosphorelay sensor kinase activity
GFH30_01210	COG0181	hydroxymethylbilane synthase activity
GFH30_01260	COG0546	phosphoglycolate phosphatase activity
GFH30_01305	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GFH30_01310	COG0081	regulation of translation
GFH30_01315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GFH30_01320	COG0222	ribosome binding
GFH30_01325	COG0085	RNA polymerase activity
GFH30_01355	COG2056	Na+-H+ antiporter family
GFH30_01370	COG0326	Molecular chaperone. Has ATPase activity
GFH30_01390	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GFH30_01395	COG0427	acetyl-CoA hydrolase
GFH30_01400	COG2205	protein histidine kinase activity
GFH30_01405	COG0745	RESPONSE REGULATOR receiver
GFH30_01430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GFH30_01460	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GFH30_01465	COG1074	ATP-dependent DNA helicase activity
GFH30_01470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFH30_01475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GFH30_01480	COG1185	polyribonucleotide nucleotidyltransferase activity
GFH30_01485	COG2841	Protein conserved in bacteria
GFH30_01490	COG0789	Transcriptional regulator
GFH30_01495	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GFH30_01505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GFH30_01525	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GFH30_01530	COG4535	Mg2 and Co2 transporter CorC
GFH30_01535	COG0425	Belongs to the sulfur carrier protein TusA family
GFH30_01540	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GFH30_01540	COG0644	oxidoreductase
GFH30_01550	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GFH30_01565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFH30_01570	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GFH30_01580	COG0493	'glutamate synthase
GFH30_01610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFH30_01635	COG0751	glycine-tRNA ligase activity
GFH30_01655	COG1983	PspC domain protein
GFH30_01685	COG0318	PFAM AMP-dependent synthetase and ligase
GFH30_01690	COG1530	ribonuclease E activity
GFH30_01695	COG0564	pseudouridine synthase activity
GFH30_01700	COG0546	phosphoglycolate phosphatase activity
GFH30_01705	COG3971	2-oxopent-4-enoate hydratase activity
GFH30_01710	COG4569	acetaldehyde dehydrogenase (acetylating) activity
GFH30_01730	COG0583	DNA-binding transcription factor activity
GFH30_01735	COG4638	Rieske (2fe-2S)
GFH30_01750	COG1028	Short-chain dehydrogenase reductase Sdr
GFH30_01755	COG3384	dioxygenase
GFH30_01760	COG0446	pyridine nucleotide-disulphide oxidoreductase
GFH30_01775	COG0753	catalase activity
GFH30_01795	COG0494	nUDIX hydrolase
GFH30_01800	COG0560	Phosphoserine phosphatase
GFH30_01835	COG0473	3-isopropylmalate dehydrogenase activity
GFH30_01860	COG0252	asparaginase activity
GFH30_01885	COG1560	Kdo2-lipid A biosynthetic process
GFH30_01925	COG0210	DNA helicase
GFH30_01945	COG4651	solute:proton antiporter activity
GFH30_01945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GFH30_01950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GFH30_01955	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GFH30_01970	COG0788	formyltetrahydrofolate deformylase activity
GFH30_02010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GFH30_02015	COG3040	lipid binding
GFH30_02070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GFH30_02080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GFH30_02080	COG2813	Specifically methylates the guanine in position
GFH30_02090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFH30_02100	COG4774	siderophore transport
GFH30_02110	COG0740	serine-type endopeptidase activity
GFH30_02135	COG0857	belongs to the CobB CobQ family
GFH30_02135	COG0280	phosphate acetyltransferase
GFH30_02140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GFH30_02165	COG0793	Belongs to the peptidase S41A family
GFH30_02175	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GFH30_02190	COG0084	hydrolase, TatD family'
GFH30_02215	COG1162	GTPase activity
GFH30_02220	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GFH30_02225	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GFH30_02235	COG1538	Outer membrane efflux protein
GFH30_02240	COG1136	(ABC) transporter
GFH30_02240	COG0577	efflux transmembrane transporter activity
GFH30_02245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFH30_02270	COG0028	Belongs to the TPP enzyme family
GFH30_02275	COG0440	acetolactate synthase activity
GFH30_02280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GFH30_02295	COG2975	iron-sulfur cluster assembly
GFH30_02315	COG1426	Protein conserved in bacteria
GFH30_02325	COG0124	histidyl-tRNA synthetase
GFH30_02355	COG0300	oxidoreductase activity
GFH30_02360	COG3956	TIGRFAM MazG family protein
GFH30_02365	COG1555	photosystem II stabilization
GFH30_02370	COG0617	tRNA 3'-terminal CCA addition
GFH30_02375	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GFH30_02390	COG1660	Displays ATPase and GTPase activities
GFH30_02395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFH30_02405	COG0784	Response regulator, receiver
GFH30_02405	COG2205	protein histidine kinase activity
GFH30_02405	COG5002	protein histidine kinase activity
GFH30_02410	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GFH30_02435	COG0438	transferase activity, transferring glycosyl groups
GFH30_02460	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GFH30_02490	COG3223	Belongs to the PsiE family
GFH30_02500	COG1960	acyl-CoA dehydrogenase activity
GFH30_02505	COG1960	acyl-CoA dehydrogenase activity
GFH30_02515	COG2205	protein histidine kinase activity
GFH30_02520	COG0745	RESPONSE REGULATOR receiver
GFH30_02525	COG0318	PFAM AMP-dependent synthetase and ligase
GFH30_02530	COG0069	glutamate synthase activity
GFH30_02535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GFH30_02540	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GFH30_02550	COG0625	glutathione transferase activity
GFH30_02560	COG1238	metal cluster binding
GFH30_02580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GFH30_02595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GFH30_02600	COG0072	phenylalanine-tRNA ligase activity
GFH30_02635	COG0037	tRNA processing
GFH30_02675	COG1764	response to oxidative stress
GFH30_02680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFH30_02695	COG2853	Lipoprotein
GFH30_02745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GFH30_02750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GFH30_02800	COG0494	nUDIX hydrolase
GFH30_02810	COG1214	PFAM Peptidase M22, glycoprotease
GFH30_02815	COG1968	undecaprenyl-diphosphatase activity
GFH30_02830	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GFH30_02835	COG4269	membrane
GFH30_02850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GFH30_02855	COG2076	Multidrug Resistance protein
GFH30_02860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GFH30_02870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GFH30_02895	COG4969	Belongs to the N-Me-Phe pilin family
GFH30_02910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GFH30_02915	COG3545	Serine hydrolase
GFH30_02930	COG0730	response to heat
GFH30_02940	COG1196	nuclear chromosome segregation
GFH30_02950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFH30_02955	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GFH30_02960	COG2193	ferroxidase activity
GFH30_02970	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GFH30_02975	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GFH30_02980	COG0009	L-threonylcarbamoyladenylate synthase
GFH30_02985	COG3101	peptidyl-lysine hydroxylation
GFH30_02990	COG1399	metal-binding, possibly nucleic acid-binding protein
GFH30_02995	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GFH30_03000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GFH30_03010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFH30_03015	COG1652	LysM domain
GFH30_03035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GFH30_03060	COG0456	acetyltransferase
GFH30_03070	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GFH30_03075	COG0492	ferredoxin-NADP+ reductase activity
GFH30_03080	COG1674	ftsk spoiiie
GFH30_03080	COG0531	amino acid
GFH30_03090	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GFH30_03100	COG0850	regulation of cytokinetic process
GFH30_03110	COG0204	Acyl-transferase
GFH30_03115	COG2885	chlorophyll binding
GFH30_03120	COG0210	DNA helicase
GFH30_03125	COG0756	dUTP diphosphatase activity
GFH30_03140	COG0121	glutamine amidotransferase
GFH30_03155	COG2914	Belongs to the UPF0125 (RnfH) family
GFH30_03160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GFH30_03165	COG0735	belongs to the Fur family
GFH30_03180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GFH30_03205	COG2050	protein possibly involved in aromatic compounds catabolism
GFH30_03215	COG2814	Major facilitator Superfamily
GFH30_03220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GFH30_03230	COG0582	viral genome integration into host DNA
GFH30_03245	COG3646	Phage regulatory protein
GFH30_03320	COG3177	Filamentation induced by cAMP protein fic
GFH30_03355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFH30_03370	COG2271	Major facilitator Superfamily
GFH30_03380	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GFH30_03395	COG0625	glutathione transferase activity
GFH30_03420	COG1846	Transcriptional regulator
GFH30_03430	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
GFH30_03470	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFH30_03480	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFH30_03485	COG1077	Cell shape determining protein MreB Mrl
GFH30_03490	COG1792	Involved in formation and maintenance of cell shape
GFH30_03495	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GFH30_03500	COG0424	maF-like protein
GFH30_03505	COG1530	ribonuclease E activity
GFH30_03510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFH30_03545	COG1113	amino acid transport
GFH30_03550	COG2828	Protein conserved in bacteria
GFH30_03555	COG0142	geranyltranstransferase activity
GFH30_03560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFH30_03575	COG1752	Esterase of the alpha-beta hydrolase superfamily
GFH30_03600	COG2323	membrane
GFH30_03630	COG0525	valine-tRNA ligase activity
GFH30_03640	COG0300	oxidoreductase activity
GFH30_03645	COG2066	Belongs to the glutaminase family
GFH30_03655	COG2376	Dihydroxyacetone kinase
GFH30_03670	COG0306	phosphate transporter
GFH30_03680	COG4607	ABC-type enterochelin transport system periplasmic component
GFH30_03695	COG4771	TonB-dependent receptor
GFH30_03720	COG4181	ATPase activity
GFH30_03725	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GFH30_03735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFH30_03750	COG0583	DNA-binding transcription factor activity
GFH30_03760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GFH30_03765	COG1773	rubredoxin
GFH30_03770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFH30_03790	COG2354	Protein conserved in bacteria
GFH30_03795	COG2321	neutral zinc metallopeptidase
GFH30_03830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFH30_03830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GFH30_03845	COG1028	Short-chain dehydrogenase reductase Sdr
GFH30_03850	COG2072	flavoprotein involved in K transport
GFH30_03860	COG2009	succinate dehydrogenase
GFH30_03865	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GFH30_03870	COG1053	succinate dehydrogenase
GFH30_03875	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GFH30_03890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFH30_03900	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GFH30_03910	COG2268	Band 7 protein
GFH30_03925	COG0175	sulfate reduction
GFH30_03975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GFH30_03990	COG0477	Major facilitator Superfamily
GFH30_04000	COG1597	lipid kinase activity
GFH30_04060	COG0742	ribosomal rna small subunit methyltransferase
GFH30_04065	COG0768	penicillin binding
GFH30_04090	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GFH30_04100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFH30_04110	COG3384	dioxygenase
GFH30_04125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GFH30_04175	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GFH30_04190	COG0546	phosphoglycolate phosphatase activity
GFH30_04220	COG4771	TonB-dependent receptor
GFH30_04225	COG0500	methyltransferase
GFH30_04250	COG0006	proline dipeptidase activity
GFH30_04260	COG2155	Conserved Protein
GFH30_04265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFH30_04270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFH30_04315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GFH30_04320	COG1388	LysM domain
GFH30_04320	COG0741	lytic transglycosylase activity
GFH30_04325	COG4166	transmembrane transport
GFH30_04330	COG4174	ABC transporter (Permease)
GFH30_04335	COG4239	(ABC) transporter, permease
GFH30_04340	COG4172	Belongs to the ABC transporter superfamily
GFH30_04375	COG0833	amino acid
GFH30_04385	COG0833	amino acid
GFH30_04390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GFH30_04395	COG0418	dihydroorotase activity
GFH30_04400	COG5001	Diguanylate cyclase
GFH30_04400	COG3706	GGDEF domain
GFH30_04400	COG4251	negative regulation of phosphorylation
GFH30_04400	COG2203	Gaf domain
GFH30_04415	COG0446	pyridine nucleotide-disulphide oxidoreductase
GFH30_04415	COG1902	pentaerythritol trinitrate reductase activity
GFH30_04425	COG1741	Belongs to the pirin family
GFH30_04440	COG3739	integral membrane protein
GFH30_04455	COG3706	GGDEF domain
GFH30_04470	COG0302	gtp cyclohydrolase
GFH30_04480	COG0134	indole-3-glycerol-phosphate synthase activity
GFH30_04485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GFH30_04490	COG0512	Glutamine amidotransferase of anthranilate synthase
GFH30_04505	COG3161	chorismate lyase activity
GFH30_04510	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GFH30_04550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GFH30_04555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GFH30_04560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFH30_04565	COG0596	Alpha beta hydrolase
GFH30_04570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH30_04575	COG1335	isochorismatase
GFH30_04580	COG0251	oxidation-reduction process
GFH30_04585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFH30_04590	COG2233	PERMEase
GFH30_04595	COG2084	Dehydrogenase
GFH30_04605	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GFH30_04610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFH30_04625	COG2175	clavaminate synthase activity
GFH30_04650	COG0556	nucleotide-excision repair
GFH30_04680	COG0702	epimerase
GFH30_04685	COG1733	regulation of RNA biosynthetic process
GFH30_04700	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GFH30_04705	COG0671	phosphoesterase, PA-phosphatase related
GFH30_04715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GFH30_04720	COG0076	glutamate decarboxylase activity
GFH30_04725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GFH30_04730	COG0573	inorganic phosphate transmembrane transporter activity
GFH30_04740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GFH30_04755	COG0616	signal peptide processing
GFH30_04790	COG0482	sulfurtransferase activity
GFH30_04805	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GFH30_04810	COG1686	Belongs to the peptidase S11 family
GFH30_04830	COG1388	LysM domain
GFH30_04830	COG4942	peptidase
GFH30_04835	COG0583	DNA-binding transcription factor activity
GFH30_04840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFH30_04845	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GFH30_04850	COG1067	ATP-dependent peptidase activity
GFH30_04890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GFH30_04895	COG1966	Carbon starvation protein
GFH30_04900	COG2879	small protein
GFH30_04915	COG0714	Associated with various cellular activities
GFH30_04950	COG3646	Phage regulatory protein
GFH30_04970	COG0582	viral genome integration into host DNA
GFH30_04975	COG0582	viral genome integration into host DNA
GFH30_05055	COG1765	OsmC-like protein
GFH30_05065	COG0667	Aldo Keto reductase
GFH30_05085	COG0540	Belongs to the ATCase OTCase family
GFH30_05115	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GFH30_05120	COG0659	secondary active sulfate transmembrane transporter activity
GFH30_05130	COG2363	Small membrane protein
GFH30_05150	COG0513	Belongs to the DEAD box helicase family
GFH30_05160	COG0778	Nitroreductase
GFH30_05165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GFH30_05185	COG0167	dihydroorotate dehydrogenase activity
GFH30_05215	COG4783	chaperone-mediated protein folding
GFH30_05220	COG1610	YqeY-like protein
GFH30_05225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GFH30_05250	COG2815	serine threonine protein kinase
GFH30_05250	COG0515	serine threonine protein kinase
GFH30_05270	COG2826	transposase and inactivated derivatives, IS30 family
GFH30_05305	COG2826	transposase and inactivated derivatives, IS30 family
GFH30_05330	COG0612	Peptidase, M16
GFH30_05365	COG0352	thiamine-phosphate diphosphorylase activity
GFH30_05460	COG2391	methyltransferase activity
GFH30_05470	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GFH30_05480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GFH30_05505	COG0519	Catalyzes the synthesis of GMP from XMP
GFH30_05505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GFH30_05530	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GFH30_05530	COG0517	IMP dehydrogenase activity
GFH30_05535	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GFH30_05545	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GFH30_05550	COG1137	ATPase activity
GFH30_05555	COG1538	Outer membrane efflux protein
GFH30_05560	COG1132	(ABC) transporter
GFH30_05595	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GFH30_05605	COG2203	Gaf domain
GFH30_05605	COG3706	GGDEF domain
GFH30_05605	COG5001	Diguanylate cyclase
GFH30_05605	COG4251	negative regulation of phosphorylation
GFH30_05645	COG2011	ABC-type metal ion transport system permease component
GFH30_05650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GFH30_05655	COG1464	Belongs to the NlpA lipoprotein family
GFH30_05670	COG0151	Belongs to the GarS family
GFH30_05675	COG0138	bifunctional purine biosynthesis protein purh
GFH30_05680	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GFH30_05725	COG3852	Histidine kinase
GFH30_05735	COG0528	UMP kinase activity
GFH30_05745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GFH30_05750	COG0575	Belongs to the CDS family
GFH30_05765	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GFH30_05775	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFH30_05780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFH30_05785	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFH30_05810	COG2137	regulation of response to DNA damage stimulus
GFH30_05815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GFH30_05820	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GFH30_05825	COG1011	Hydrolase
GFH30_05830	COG1218	3'(2'),5'-bisphosphate nucleotidase
GFH30_05850	COG0702	epimerase
GFH30_05855	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GFH30_05870	COG4585	Histidine kinase
GFH30_05875	COG2850	peptidyl-arginine hydroxylation
GFH30_05885	COG0424	maF-like protein
GFH30_05905	COG0191	fructose-bisphosphate aldolase activity
GFH30_05910	COG0697	spore germination
GFH30_05930	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFH30_05965	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GFH30_05965	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GFH30_05965	COG0506	proline dehydrogenase activity
GFH30_05985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GFH30_06015	COG0316	Belongs to the HesB IscA family
GFH30_06020	COG0822	iron-sulfur transferase activity
GFH30_06045	COG0776	regulation of translation
GFH30_06050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GFH30_06070	COG1585	Membrane protein implicated in regulation of membrane protease activity
GFH30_06080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFH30_06100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GFH30_06105	COG0569	domain protein
GFH30_06110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GFH30_06115	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GFH30_06135	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GFH30_06140	COG0542	response to heat
GFH30_06165	COG0372	Belongs to the citrate synthase family
GFH30_06195	COG3706	GGDEF domain
GFH30_06205	COG0439	Biotin carboxylase
GFH30_06240	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GFH30_06245	COG0582	viral genome integration into host DNA
GFH30_06280	COG5377	YqaJ viral recombinase family
GFH30_06505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFH30_06545	COG0596	Alpha beta hydrolase
GFH30_06555	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GFH30_06570	COG0500	methyltransferase
GFH30_06595	COG3706	GGDEF domain
GFH30_06615	COG0318	PFAM AMP-dependent synthetase and ligase
GFH30_06630	COG0804	urea catabolic process
GFH30_06650	COG0829	nickel cation binding
GFH30_06660	COG0830	nickel cation binding
GFH30_06665	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GFH30_06675	COG0427	acetyl-CoA hydrolase
GFH30_06680	COG0183	Belongs to the thiolase family
GFH30_06685	COG1960	acyl-CoA dehydrogenase activity
GFH30_06700	COG0789	Transcriptional regulator
GFH30_06710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFH30_06715	COG0640	Transcriptional regulator
GFH30_06735	COG3122	Protein conserved in bacteria
GFH30_06740	COG1132	(ABC) transporter
GFH30_06755	COG0509	glycine decarboxylation via glycine cleavage system
GFH30_06760	COG2814	Major facilitator Superfamily
GFH30_06770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GFH30_06780	COG1113	amino acid transport
GFH30_06785	COG1448	Aminotransferase
GFH30_06790	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GFH30_06795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GFH30_06850	COG0583	DNA-binding transcription factor activity
GFH30_06855	COG1525	nuclease
GFH30_06865	COG2814	Major facilitator Superfamily
GFH30_06870	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GFH30_06875	COG2207	Transcriptional regulator
GFH30_06880	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFH30_06885	COG0730	response to heat
GFH30_06890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GFH30_06950	COG1960	acyl-CoA dehydrogenase activity
GFH30_06955	COG1960	acyl-CoA dehydrogenase activity
GFH30_06995	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GFH30_07005	COG0552	protein localization to endoplasmic reticulum
GFH30_07010	COG0612	Peptidase, M16
GFH30_07015	COG0612	Peptidase, M16
GFH30_07040	COG0517	IMP dehydrogenase activity
GFH30_07045	COG0133	tryptophan synthase activity
GFH30_07055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFH30_07075	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GFH30_07105	COG0537	adenosine 5'-monophosphoramidase activity
GFH30_07125	COG1294	oxidase, subunit
GFH30_07130	COG4890	Cyd operon protein YbgT
GFH30_07150	COG0772	Belongs to the SEDS family
GFH30_07165	COG0148	phosphopyruvate hydratase activity
GFH30_07195	COG1902	pentaerythritol trinitrate reductase activity
GFH30_07195	COG0446	pyridine nucleotide-disulphide oxidoreductase
GFH30_07210	COG0583	DNA-binding transcription factor activity
GFH30_07215	COG0024	Methionine aminopeptidase
GFH30_07220	COG1114	Component of the transport system for branched-chain amino acids
GFH30_07240	COG0786	glutamate:sodium symporter activity
GFH30_07335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GFH30_07340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFH30_07345	COG2890	protein-(glutamine-N5) methyltransferase activity
GFH30_07365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH30_07385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GFH30_07395	COG1845	cytochrome c oxidase, subunit III
GFH30_07400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GFH30_07410	COG0360	Binds together with S18 to 16S ribosomal RNA
GFH30_07430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GFH30_07445	COG1305	Transglutaminase-like
GFH30_07455	COG2308	Evidence 4 Homologs of previously reported genes of
GFH30_07465	COG0069	glutamate synthase activity
GFH30_07485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFH30_07490	COG1454	alcohol dehydrogenase
GFH30_07495	COG0824	Thioesterase
GFH30_07500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GFH30_07520	COG1028	Short-chain dehydrogenase reductase Sdr
GFH30_07525	COG0183	Belongs to the thiolase family
GFH30_07545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GFH30_07560	COG0589	response to stress
GFH30_07575	COG0308	aminopeptidase N
GFH30_07610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GFH30_07615	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GFH30_07630	COG2431	L-lysine efflux transmembrane transporter activity
GFH30_07635	COG0284	orotidine-5'-phosphate decarboxylase activity
GFH30_07645	COG0776	regulation of translation
GFH30_07665	COG0590	tRNA wobble adenosine to inosine editing
GFH30_07675	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GFH30_07700	COG2165	general secretion pathway protein
GFH30_07705	COG1309	transcriptional regulator
GFH30_07710	COG0084	hydrolase, TatD family'
GFH30_07730	COG1663	tetraacyldisaccharide 4'-kinase activity
GFH30_07735	COG1132	(ABC) transporter
GFH30_07745	COG0811	peptide transport
GFH30_07750	COG1475	DNA binding
GFH30_07755	COG1192	Involved in chromosome partitioning
GFH30_07765	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GFH30_07770	COG3178	'Phosphotransferase
GFH30_07780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GFH30_07785	COG1923	regulation of RNA biosynthetic process
GFH30_07795	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GFH30_07800	COG0802	atpase or kinase
GFH30_07820	COG1187	pseudouridine synthase activity
GFH30_07830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFH30_07850	COG1643	Atp-dependent helicase
GFH30_07855	COG0450	alkyl hydroperoxide reductase
GFH30_07875	COG3634	alkyl hydroperoxide reductase activity
GFH30_07900	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GFH30_07905	COG1254	Belongs to the acylphosphatase family
GFH30_07910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GFH30_07910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GFH30_07935	COG0582	viral genome integration into host DNA
GFH30_07960	COG1203	CRISPR-associated helicase, Cas3
GFH30_07990	COG0582	viral genome integration into host DNA
GFH30_08015	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GFH30_08020	COG0732	type I restriction modification DNA specificity domain
GFH30_08025	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GFH30_08025	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GFH30_08030	COG3620	sequence-specific DNA binding
GFH30_08060	COG0204	Acyl-transferase
GFH30_08080	COG0012	GTP binding
GFH30_08100	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GFH30_08130	COG0386	Belongs to the glutathione peroxidase family
GFH30_08135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFH30_08155	COG2351	hydroxyisourate hydrolase activity
GFH30_08170	COG1686	Belongs to the peptidase S11 family
GFH30_08175	COG1252	NADH dehydrogenase
GFH30_08200	COG0501	Belongs to the peptidase M48B family
GFH30_08205	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GFH30_08230	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GFH30_08255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GFH30_08260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFH30_08265	COG0527	aspartate kinase activity
GFH30_08275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GFH30_08290	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GFH30_08295	COG2252	PERMEase
GFH30_08315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GFH30_08320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GFH30_08330	COG0693	protein deglycase activity
GFH30_08335	COG1960	acyl-CoA dehydrogenase activity
GFH30_08340	COG1301	dicarboxylic acid transport
GFH30_08350	COG3139	Protein of unknown function (DUF1315)
GFH30_08355	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GFH30_08360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFH30_08370	COG0494	nUDIX hydrolase
GFH30_08380	COG0642	Histidine kinase
GFH30_08385	COG0745	RESPONSE REGULATOR receiver
GFH30_08395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GFH30_08400	COG1720	tRNA m6t6A37 methyltransferase activity
GFH30_08415	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GFH30_08420	COG3634	alkyl hydroperoxide reductase activity
GFH30_08440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GFH30_08475	COG1944	ATP diphosphatase activity
GFH30_08485	COG0583	DNA-binding transcription factor activity
GFH30_08490	COG1027	Aspartate ammonia-lyase
GFH30_08505	COG0583	DNA-binding transcription factor activity
GFH30_08515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFH30_08520	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GFH30_08585	COG1053	succinate dehydrogenase
GFH30_08590	COG0583	DNA-binding transcription factor activity
GFH30_08610	COG1131	(ABC) transporter
GFH30_08615	COG0842	Transport permease protein
GFH30_08630	COG2951	lytic endotransglycosylase activity
GFH30_08655	COG0052	Belongs to the universal ribosomal protein uS2 family
GFH30_08660	COG0024	Methionine aminopeptidase
GFH30_08690	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GFH30_08705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GFH30_08710	COG0571	ribonuclease III activity
GFH30_08735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFH30_08765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GFH30_08770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFH30_08775	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GFH30_08780	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GFH30_08795	COG4208	sulfate ABC transporter
GFH30_08800	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GFH30_08805	COG0583	DNA-binding transcription factor activity
GFH30_08825	COG0602	queuosine metabolic process
GFH30_08830	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GFH30_08840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFH30_08845	COG1279	arginine transmembrane transporter activity
GFH30_08850	COG0583	DNA-binding transcription factor activity
GFH30_08855	COG2353	YceI-like domain
GFH30_08860	COG1051	belongs to the nudix hydrolase family
GFH30_08860	COG1056	cytidyltransferase-related domain
GFH30_08865	COG1024	Enoyl-CoA hydratase
GFH30_08870	COG0778	Nitroreductase
GFH30_08895	COG2234	aminopeptidase activity
GFH30_08910	COG2255	four-way junction helicase activity
GFH30_08930	COG0824	Thioesterase
GFH30_08935	COG0811	peptide transport
GFH30_08950	COG0823	Involved in the tonB-independent uptake of proteins
GFH30_08955	COG2885	chlorophyll binding
GFH30_08970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFH30_09005	COG0628	permease
GFH30_09015	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GFH30_09035	COG0658	competence protein
GFH30_09035	COG2333	competence protein COMEC
GFH30_09040	COG1136	(ABC) transporter
GFH30_09045	COG4591	ABC-type transport system involved in lipoprotein release permease component
GFH30_09055	COG0697	spore germination
GFH30_09060	COG1671	Belongs to the UPF0178 family
GFH30_09125	COG1280	lysine exporter protein (LysE YggA)
GFH30_09130	COG1522	sequence-specific DNA binding
GFH30_09140	COG0154	amidase activity
GFH30_09145	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GFH30_09155	COG0019	diaminopimelate decarboxylase activity
GFH30_09165	COG1113	amino acid transport
GFH30_09170	COG1115	amino acid carrier protein
GFH30_09195	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GFH30_09200	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GFH30_09205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GFH30_09230	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GFH30_09250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GFH30_09265	COG0037	tRNA processing
GFH30_09270	COG0739	heme binding
GFH30_09270	COG1196	nuclear chromosome segregation
GFH30_09270	COG0741	lytic transglycosylase activity
GFH30_09290	COG2239	Acts as a magnesium transporter
GFH30_09315	COG1253	flavin adenine dinucleotide binding
GFH30_09350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GFH30_09360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFH30_09385	COG0505	Belongs to the CarA family
GFH30_09390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GFH30_09420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GFH30_09445	COG0564	pseudouridine synthase activity
GFH30_09455	COG0358	DNA primase activity
GFH30_09470	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GFH30_09500	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GFH30_09505	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GFH30_09520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFH30_09560	COG0586	Pfam SNARE associated Golgi protein
GFH30_09580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFH30_09590	COG0321	lipoyl(octanoyl) transferase activity
GFH30_09605	COG0531	amino acid
GFH30_09615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GFH30_09620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GFH30_09620	COG1648	precorrin-2 dehydrogenase activity
GFH30_09630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GFH30_09635	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GFH30_09640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GFH30_09655	COG0671	phosphoesterase, PA-phosphatase related
GFH30_09660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFH30_09670	COG1538	Outer membrane efflux protein
GFH30_09675	COG0393	Putative heavy-metal-binding
GFH30_09685	COG0242	peptide deformylase activity
GFH30_09725	COG4681	YaeQ
GFH30_09730	COG0523	cobalamin synthesis protein
GFH30_09740	COG2814	Major facilitator Superfamily
GFH30_09745	COG1309	transcriptional regulator
GFH30_09750	COG1607	acyl-coa hydrolase
GFH30_09755	COG1752	Esterase of the alpha-beta hydrolase superfamily
GFH30_09760	COG1115	amino acid carrier protein
GFH30_09765	COG0786	glutamate:sodium symporter activity
GFH30_09775	COG2814	Major facilitator Superfamily
GFH30_09780	COG1289	transmembrane transporter activity
GFH30_09790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GFH30_09845	COG1376	ErfK ybiS ycfS ynhG family protein
GFH30_09850	COG2832	Protein of unknown function (DUF454)
GFH30_09865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFH30_09880	COG0840	transmembrane signaling receptor activity
GFH30_09905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFH30_09915	COG0442	prolyl-tRNA aminoacylation
GFH30_09945	COG0489	protein tyrosine kinase activity
GFH30_09965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFH30_09965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFH30_10000	COG2081	HI0933 family
GFH30_10010	COG0668	transmembrane transport
GFH30_10040	COG0640	Transcriptional regulator
GFH30_10050	COG0583	DNA-binding transcription factor activity
GFH30_10055	COG1278	Cold shock
GFH30_10065	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GFH30_10075	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH30_10080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFH30_10085	COG0713	ATP synthesis coupled electron transport
GFH30_10095	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH30_10110	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GFH30_10120	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH30_10120	COG0649	NAD binding
GFH30_10140	COG2205	protein histidine kinase activity
GFH30_10145	COG0745	RESPONSE REGULATOR receiver
GFH30_10155	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFH30_10160	COG4772	TonB-dependent receptor
GFH30_10235	COG0351	phosphomethylpyrimidine kinase
GFH30_10235	COG0352	thiamine-phosphate diphosphorylase activity
GFH30_10235	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GFH30_10245	COG2824	Alkylphosphonate utilization operon protein PhnA
GFH30_10260	COG0564	pseudouridine synthase activity
GFH30_10295	COG0354	folic acid binding
GFH30_10315	COG1902	pentaerythritol trinitrate reductase activity
GFH30_10345	COG2233	PERMEase
GFH30_10355	COG0833	amino acid
GFH30_10365	COG2885	chlorophyll binding
GFH30_10365	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GFH30_10375	COG0183	Belongs to the thiolase family
GFH30_10385	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GFH30_10395	COG2207	Transcriptional regulator
GFH30_10400	COG0183	Belongs to the thiolase family
GFH30_10405	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFH30_10405	COG1024	Enoyl-CoA hydratase
GFH30_10425	COG1272	protein, Hemolysin III
GFH30_10430	COG0477	Major facilitator Superfamily
GFH30_10440	COG1408	metallophosphoesterase
GFH30_10445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GFH30_10455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GFH30_10480	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GFH30_10485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GFH30_10490	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GFH30_10495	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GFH30_10500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GFH30_10505	COG0625	glutathione transferase activity
GFH30_10510	COG2969	positive regulation of protein catabolic process
GFH30_10600	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GFH30_10605	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GFH30_10620	COG0450	alkyl hydroperoxide reductase
GFH30_10635	COG0285	dihydrofolate synthase activity
GFH30_10675	COG0133	tryptophan synthase activity
GFH30_10685	COG4206	TonB-dependent receptor
GFH30_10690	COG2096	Adenosyltransferase
GFH30_10710	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GFH30_10715	COG2315	Protein conserved in bacteria
GFH30_10720	COG1113	amino acid transport
GFH30_10730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GFH30_10755	COG1862	Preprotein translocase
GFH30_10765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GFH30_10775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GFH30_10805	COG2084	Dehydrogenase
GFH30_10810	COG3622	Belongs to the hyi family
GFH30_10825	COG0004	ammonium transporteR
GFH30_10830	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GFH30_10835	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GFH30_10840	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GFH30_10845	COG2814	Major facilitator Superfamily
GFH30_10855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GFH30_10865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GFH30_10870	COG2003	Belongs to the UPF0758 family
GFH30_10875	COG3781	membrane
GFH30_10890	COG2350	Protein conserved in bacteria
GFH30_10925	COG1607	acyl-coa hydrolase
GFH30_10940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFH30_10940	COG3453	Protein conserved in bacteria
GFH30_10990	COG1183	phosphatidylcholine synthase activity
GFH30_10995	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GFH30_11030	COG0741	lytic transglycosylase activity
GFH30_11030	COG0739	heme binding
GFH30_11030	COG1196	nuclear chromosome segregation
GFH30_11040	COG1702	phosphate starvation-inducible protein PhoH
GFH30_11045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GFH30_11080	COG1295	ribonuclease BN
GFH30_11120	COG0557	exoribonuclease II activity
GFH30_11125	COG0339	signal peptide processing
GFH30_11130	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GFH30_11165	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GFH30_11170	COG1960	acyl-CoA dehydrogenase activity
GFH30_11175	COG2072	flavoprotein involved in K transport
GFH30_11180	COG0203	ribosomal protein L17
GFH30_11185	COG0202	RNA polymerase activity
GFH30_11190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GFH30_11195	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GFH30_11200	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GFH30_11205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GFH30_11225	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GFH30_11235	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GFH30_11240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GFH30_11285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GFH30_11290	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GFH30_11300	COG0089	rRNA binding
GFH30_11305	COG0088	Forms part of the polypeptide exit tunnel
GFH30_11325	COG0626	cystathionine gamma-synthase activity
GFH30_11330	COG0433	COG0433 Predicted ATPase
GFH30_11335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GFH30_11335	COG1017	nitric oxide dioxygenase activity
GFH30_11340	COG1959	2 iron, 2 sulfur cluster binding
GFH30_11355	COG1301	dicarboxylic acid transport
GFH30_11360	COG1946	Acyl-CoA thioesterase
GFH30_11365	COG2937	Belongs to the GPAT DAPAT family
GFH30_11375	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GFH30_11380	COG1040	competence protein
GFH30_11385	COG0494	nUDIX hydrolase
GFH30_11395	COG0598	Magnesium transport protein CorA
GFH30_11405	COG2854	intermembrane phospholipid transfer
GFH30_11410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GFH30_11415	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GFH30_11420	COG1127	ABC transporter
GFH30_11425	COG0513	Belongs to the DEAD box helicase family
GFH30_11445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFH30_11465	COG1960	acyl-CoA dehydrogenase activity
GFH30_11470	COG1278	Cold shock
GFH30_11480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFH30_11490	COG0534	Mate efflux family protein
GFH30_11500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GFH30_11505	COG0254	rRNA binding
GFH30_11510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GFH30_11525	COG2226	methyltransferase
GFH30_11540	COG1192	Involved in chromosome partitioning
GFH30_11545	COG0628	permease
GFH30_11550	COG2032	superoxide dismutase activity
GFH30_11580	COG0277	FAD linked oxidase domain protein
GFH30_11585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFH30_11590	COG5006	permease, DMT superfamily
GFH30_11595	COG5006	permease, DMT superfamily
GFH30_11610	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GFH30_11615	COG5380	lipid catabolic process
GFH30_11620	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GFH30_11630	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GFH30_11635	COG0335	large ribosomal subunit rRNA binding
GFH30_11645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GFH30_11650	COG0228	four-way junction DNA binding
GFH30_11660	COG2165	general secretion pathway protein
GFH30_11685	COG4968	Prepilin-type N-terminal cleavage methylation domain
GFH30_11695	COG0194	GDP metabolic process
GFH30_11700	COG1758	RNA polymerase activity
GFH30_11705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GFH30_11715	COG2906	2 iron, 2 sulfur cluster binding
GFH30_11725	COG3307	-O-antigen
GFH30_11735	COG3307	-O-antigen
GFH30_11740	COG4969	Belongs to the N-Me-Phe pilin family
GFH30_11755	COG1704	LemA family
GFH30_11765	COG0493	'glutamate synthase
GFH30_11770	COG0069	glutamate synthase activity
GFH30_11770	COG0067	glutamate synthase
GFH30_11770	COG0070	glutamate synthase
GFH30_11820	COG2226	methyltransferase
GFH30_11825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFH30_11830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFH30_11835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GFH30_11860	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GFH30_11865	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GFH30_11900	COG0488	(ABC) transporter
GFH30_11910	COG4221	oxidoreductase activity
GFH30_11915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GFH30_11930	COG2111	Na H antiporter
GFH30_11930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFH30_11935	COG1006	Multisubunit Na H antiporter MnhC subunit
GFH30_11950	COG2212	antiporter activity
GFH30_11960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GFH30_11965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GFH30_11970	COG0195	Participates in both transcription termination and antitermination
GFH30_12030	COG0237	dephospho-CoA kinase activity
GFH30_12035	COG0697	spore germination
GFH30_12040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFH30_12045	COG3123	guanosine phosphorylase activity
GFH30_12050	COG0497	DNA recombination
GFH30_12060	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GFH30_12075	COG1289	transmembrane transporter activity
GFH30_12090	COG1132	(ABC) transporter
GFH30_12095	COG0704	Plays a role in the regulation of phosphate uptake
GFH30_12100	COG1538	Outer membrane efflux protein
GFH30_12115	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GFH30_12120	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GFH30_12125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GFH30_12135	COG0772	Belongs to the SEDS family
GFH30_12160	COG4974	Belongs to the 'phage' integrase family
GFH30_12165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GFH30_12175	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GFH30_12180	COG1686	Belongs to the peptidase S11 family
GFH30_12185	COG2197	response regulator
GFH30_12190	COG3852	Histidine kinase
GFH30_12200	COG0793	Belongs to the peptidase S41A family
GFH30_12210	COG0795	lipopolysaccharide-transporting ATPase activity
GFH30_12215	COG0795	lipopolysaccharide-transporting ATPase activity
GFH30_12235	COG0586	Pfam SNARE associated Golgi protein
GFH30_12250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFH30_12250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFH30_12260	COG0004	ammonium transporteR
GFH30_12265	COG0347	Belongs to the P(II) protein family
GFH30_12275	COG0606	chelatase, subunit chli
GFH30_12290	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GFH30_12305	COG0318	PFAM AMP-dependent synthetase and ligase
GFH30_12315	COG0477	Major facilitator Superfamily
GFH30_12320	COG2860	membrane
GFH30_12330	COG1253	flavin adenine dinucleotide binding
GFH30_12355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GFH30_12360	COG0477	Major facilitator Superfamily
GFH30_12430	COG0758	DNA mediated transformation
GFH30_12440	COG0697	spore germination
GFH30_12445	COG0386	Belongs to the glutathione peroxidase family
GFH30_12480	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GFH30_12490	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GFH30_12520	COG0803	Belongs to the bacterial solute-binding protein 9 family
GFH30_12525	COG0735	belongs to the Fur family
GFH30_12530	COG1121	(ABC) transporter
GFH30_12535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GFH30_12545	COG0668	transmembrane transport
GFH30_12555	COG2837	iron assimilation
GFH30_12560	COG0436	Aminotransferase
GFH30_12565	COG0534	Mate efflux family protein
GFH30_12570	COG1116	anion transmembrane transporter activity
GFH30_12575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFH30_12580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFH30_12655	COG3706	GGDEF domain
GFH30_12660	COG0745	RESPONSE REGULATOR receiver
GFH30_12660	COG3706	GGDEF domain
GFH30_12680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GFH30_12680	COG0519	Catalyzes the synthesis of GMP from XMP
GFH30_12685	COG3111	PFAM Bacterial OB fold (BOF) protein
GFH30_12690	COG2259	Doxx family
GFH30_12695	COG0586	Pfam SNARE associated Golgi protein
GFH30_12710	COG1192	Involved in chromosome partitioning
GFH30_12720	COG0271	Belongs to the BolA IbaG family
GFH30_12735	COG4628	conserved protein (DUF2132)
GFH30_12755	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GFH30_12765	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GFH30_12770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GFH30_12780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFH30_12785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFH30_12795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFH30_12810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GFH30_12820	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GFH30_12820	COG0662	Cupin 2, conserved barrel domain protein
GFH30_12865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GFH30_12875	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GFH30_12880	COG0438	transferase activity, transferring glycosyl groups
GFH30_12885	COG0438	transferase activity, transferring glycosyl groups
GFH30_12890	COG0438	transferase activity, transferring glycosyl groups
GFH30_12915	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GFH30_12955	COG1194	a g-specific adenine glycosylase
GFH30_12960	COG0739	heme binding
GFH30_12970	COG2818	Glycosylase
GFH30_12975	COG1064	alcohol dehydrogenase
GFH30_12995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GFH30_13000	COG0583	DNA-binding transcription factor activity
GFH30_13030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFH30_13045	COG2233	PERMEase
GFH30_13080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFH30_13080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFH30_13090	COG0733	neurotransmitter:sodium symporter activity
GFH30_13095	COG0693	protein deglycase activity
GFH30_13110	COG2814	Major facilitator Superfamily
GFH30_13115	COG2814	Major facilitator Superfamily
GFH30_13150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GFH30_13155	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GFH30_13160	COG2951	lytic endotransglycosylase activity
GFH30_13165	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GFH30_13180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GFH30_13190	COG2388	GCN5-related N-acetyl-transferase
GFH30_13200	COG0861	Integral membrane protein TerC family
GFH30_13205	COG0402	S-adenosylhomocysteine deaminase activity
GFH30_13220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GFH30_13235	COG0706	membrane insertase activity
GFH30_13240	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GFH30_13245	COG0594	ribonuclease P activity
GFH30_13250	COG0230	Belongs to the bacterial ribosomal protein bL34 family