locus-tag	class	description
I6I53_00050	COG0556	nucleotide-excision repair
I6I53_00105	COG0582	viral genome integration into host DNA
I6I53_00110	COG2369	cell adhesion
I6I53_00130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I53_00135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I53_00165	COG2184	nucleotidyltransferase activity
I6I53_00190	COG0697	spore germination
I6I53_00230	COG1475	DNA binding
I6I53_00235	COG1192	Involved in chromosome partitioning
I6I53_00270	COG0583	DNA-binding transcription factor activity
I6I53_00280	COG0371	Dehydrogenase
I6I53_00285	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_00290	COG0477	Major facilitator Superfamily
I6I53_00355	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I53_00380	COG2132	Multicopper oxidase
I6I53_00395	COG2205	protein histidine kinase activity
I6I53_00400	COG2217	Heavy metal translocating P-type atpase
I6I53_00440	COG0640	Transcriptional regulator
I6I53_00450	COG0798	PFAM Bile acid sodium symporter
I6I53_00455	COG0431	NADPH-dependent FMN reductase
I6I53_00465	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6I53_00475	COG0604	alcohol dehydrogenase
I6I53_00480	COG1309	transcriptional regulator
I6I53_00535	COG0583	DNA-binding transcription factor activity
I6I53_00555	COG2233	PERMEase
I6I53_00565	COG0583	DNA-binding transcription factor activity
I6I53_00595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I53_00600	COG2828	Protein conserved in bacteria
I6I53_00605	COG1113	amino acid transport
I6I53_00625	COG2333	competence protein COMEC
I6I53_00625	COG0658	competence protein
I6I53_00630	COG1136	(ABC) transporter
I6I53_00650	COG1671	Belongs to the UPF0178 family
I6I53_00660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I53_00670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I53_00695	COG2826	transposase and inactivated derivatives, IS30 family
I6I53_00705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I53_00720	COG3384	dioxygenase
I6I53_00730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I53_00735	COG2878	Part of a membrane complex involved in electron transport
I6I53_00740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I53_00750	COG0563	adenylate kinase activity
I6I53_00765	COG0768	penicillin binding
I6I53_00770	COG0742	ribosomal rna small subunit methyltransferase
I6I53_00795	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I53_00800	COG0830	nickel cation binding
I6I53_00805	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6I53_00810	COG0804	urea catabolic process
I6I53_00820	COG0832	Belongs to the urease beta subunit family
I6I53_00825	COG0831	urea catabolic process
I6I53_00830	COG0829	nickel cation binding
I6I53_00845	COG3015	lipoprotein NlpE involved in copper resistance
I6I53_00855	COG3676	manually curated
I6I53_00870	COG1253	flavin adenine dinucleotide binding
I6I53_00880	COG1116	anion transmembrane transporter activity
I6I53_00900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I53_00910	COG0864	Transcriptional regulator
I6I53_00920	COG0439	Biotin carboxylase
I6I53_00945	COG2851	Citrate transporter
I6I53_00955	COG0175	sulfate reduction
I6I53_00960	COG1492	cobalamin metabolic process
I6I53_00985	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I53_00995	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I53_01065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I53_01075	COG0193	aminoacyl-tRNA hydrolase activity
I6I53_01105	COG1054	Belongs to the UPF0176 family
I6I53_01115	COG0586	Pfam SNARE associated Golgi protein
I6I53_01120	COG0500	methyltransferase
I6I53_01145	COG0321	lipoyl(octanoyl) transferase activity
I6I53_01160	COG0531	amino acid
I6I53_01165	COG2321	neutral zinc metallopeptidase
I6I53_01170	COG2354	Protein conserved in bacteria
I6I53_01200	COG1215	transferase activity, transferring glycosyl groups
I6I53_01205	COG1649	PFAM Uncharacterised BCR, COG1649
I6I53_01205	COG0726	polysaccharide deacetylase
I6I53_01220	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I53_01225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I53_01240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I53_01245	COG1053	succinate dehydrogenase
I6I53_01250	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I53_01255	COG2009	succinate dehydrogenase
I6I53_01265	COG1607	acyl-coa hydrolase
I6I53_01275	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I53_01280	COG1309	transcriptional regulator
I6I53_01285	COG1012	belongs to the aldehyde dehydrogenase family
I6I53_01290	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I53_01315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I53_01320	COG1120	ATPase activity
I6I53_01335	COG0028	Belongs to the TPP enzyme family
I6I53_01340	COG1012	belongs to the aldehyde dehydrogenase family
I6I53_01345	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6I53_01350	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_01365	COG2271	Major facilitator Superfamily
I6I53_01370	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I53_01380	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_01400	COG1414	Transcriptional regulator
I6I53_01420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I53_01440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I53_01450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I53_01460	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I53_01470	COG0084	hydrolase, TatD family'
I6I53_01485	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I53_01500	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I53_01510	COG0028	Belongs to the TPP enzyme family
I6I53_01535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I53_01540	COG0577	efflux transmembrane transporter activity
I6I53_01540	COG1136	(ABC) transporter
I6I53_01555	COG2223	nitrite transmembrane transporter activity
I6I53_01585	COG0583	DNA-binding transcription factor activity
I6I53_01590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I53_01595	COG0436	Aminotransferase
I6I53_01600	COG1301	dicarboxylic acid transport
I6I53_01605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I53_01615	COG2223	nitrite transmembrane transporter activity
I6I53_01620	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6I53_01625	COG1877	trehalose-phosphatase activity
I6I53_01660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I53_01665	COG2814	Major facilitator Superfamily
I6I53_01670	COG1566	PFAM secretion protein HlyD family protein
I6I53_01675	COG2050	protein possibly involved in aromatic compounds catabolism
I6I53_01700	COG0420	3'-5' exonuclease activity
I6I53_01715	COG1968	undecaprenyl-diphosphatase activity
I6I53_01735	COG0735	belongs to the Fur family
I6I53_01740	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I53_01745	COG2914	Belongs to the UPF0125 (RnfH) family
I6I53_01760	COG0121	glutamine amidotransferase
I6I53_01770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I53_01775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I53_01780	COG0756	dUTP diphosphatase activity
I6I53_01790	COG2885	chlorophyll binding
I6I53_01795	COG0204	Acyl-transferase
I6I53_01805	COG0850	regulation of cytokinetic process
I6I53_01810	COG2894	cell division
I6I53_01815	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I53_01825	COG1280	lysine exporter protein (LysE YggA)
I6I53_01840	COG1674	ftsk spoiiie
I6I53_01840	COG0531	amino acid
I6I53_01845	COG0492	ferredoxin-NADP+ reductase activity
I6I53_01850	COG0500	methyltransferase
I6I53_01855	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I53_01860	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6I53_01865	COG0456	acetyltransferase
I6I53_01875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I53_01880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I53_01905	COG1981	membrane
I6I53_01925	COG0351	phosphomethylpyrimidine kinase
I6I53_01925	COG0352	thiamine-phosphate diphosphorylase activity
I6I53_01925	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I53_01930	COG1733	regulation of RNA biosynthetic process
I6I53_01940	COG1652	LysM domain
I6I53_01950	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_01965	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I53_01970	COG3101	peptidyl-lysine hydroxylation
I6I53_01975	COG0009	L-threonylcarbamoyladenylate synthase
I6I53_01985	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I53_01990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I53_02020	COG4106	trans-aconitate 2-methyltransferase activity
I6I53_02030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I53_02030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I53_02045	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I53_02060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I53_02070	COG1196	nuclear chromosome segregation
I6I53_02080	COG0730	response to heat
I6I53_02085	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6I53_02085	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6I53_02095	COG3545	Serine hydrolase
I6I53_02105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I53_02115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I53_02130	COG3422	double-strand break repair
I6I53_02135	COG0494	nUDIX hydrolase
I6I53_02140	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I53_02155	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I53_02160	COG1115	amino acid carrier protein
I6I53_02165	COG0786	glutamate:sodium symporter activity
I6I53_02180	COG2814	Major facilitator Superfamily
I6I53_02185	COG1289	transmembrane transporter activity
I6I53_02195	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I53_02240	COG1376	ErfK ybiS ycfS ynhG family protein
I6I53_02245	COG2832	Protein of unknown function (DUF454)
I6I53_02255	COG5510	response to toxic substance
I6I53_02260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I53_02275	COG0183	Belongs to the thiolase family
I6I53_02305	COG1956	GAF domain-containing protein
I6I53_02310	COG1607	acyl-coa hydrolase
I6I53_02370	COG2199	diguanylate cyclase activity
I6I53_02375	COG2885	chlorophyll binding
I6I53_02400	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I53_02405	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I53_02415	COG0653	protein targeting
I6I53_02420	COG0450	alkyl hydroperoxide reductase
I6I53_02440	COG0285	dihydrofolate synthase activity
I6I53_02445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I53_02485	COG4206	TonB-dependent receptor
I6I53_02490	COG2096	Adenosyltransferase
I6I53_02510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I53_02530	COG2205	protein histidine kinase activity
I6I53_02530	COG0784	Response regulator, receiver
I6I53_02530	COG5002	protein histidine kinase activity
I6I53_02545	COG3622	Belongs to the hyi family
I6I53_02570	COG0740	serine-type endopeptidase activity
I6I53_02575	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I53_02580	COG4774	siderophore transport
I6I53_02585	COG3128	pkhd-type hydroxylase
I6I53_02590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I53_02595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I53_02600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I53_02600	COG2813	Specifically methylates the guanine in position
I6I53_02610	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I53_02645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I53_02660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I53_02700	COG0788	formyltetrahydrofolate deformylase activity
I6I53_02705	COG1309	transcriptional regulator
I6I53_02725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I53_02725	COG4651	solute:proton antiporter activity
I6I53_02745	COG0210	DNA helicase
I6I53_02755	COG3706	GGDEF domain
I6I53_02755	COG5001	Diguanylate cyclase
I6I53_02755	COG4251	negative regulation of phosphorylation
I6I53_02755	COG2203	Gaf domain
I6I53_02780	COG2900	Belongs to the SlyX family
I6I53_02785	COG0488	(ABC) transporter
I6I53_02795	COG0405	Gamma-glutamyltransferase
I6I53_02800	COG1560	Kdo2-lipid A biosynthetic process
I6I53_02805	COG0438	transferase activity, transferring glycosyl groups
I6I53_02810	COG1301	dicarboxylic acid transport
I6I53_02845	COG0101	tRNA pseudouridine synthase activity
I6I53_02860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I53_02870	COG0473	3-isopropylmalate dehydrogenase activity
I6I53_02885	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I53_02895	COG3676	manually curated
I6I53_02900	COG0583	DNA-binding transcription factor activity
I6I53_02915	COG0494	nUDIX hydrolase
I6I53_02925	COG1960	acyl-CoA dehydrogenase activity
I6I53_02935	COG0753	catalase activity
I6I53_02940	COG4993	Dehydrogenase
I6I53_02955	COG0583	DNA-binding transcription factor activity
I6I53_02975	COG1530	ribonuclease E activity
I6I53_02980	COG0318	PFAM AMP-dependent synthetase and ligase
I6I53_02995	COG0450	alkyl hydroperoxide reductase
I6I53_03000	COG0583	DNA-binding transcription factor activity
I6I53_03005	COG4221	oxidoreductase activity
I6I53_03020	COG2826	transposase and inactivated derivatives, IS30 family
I6I53_03035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I53_03045	COG0534	Mate efflux family protein
I6I53_03060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I53_03065	COG0254	rRNA binding
I6I53_03075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I53_03095	COG0493	'glutamate synthase
I6I53_03095	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I53_03105	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6I53_03115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I53_03120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I53_03130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I53_03140	COG0644	oxidoreductase
I6I53_03140	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6I53_03155	COG0425	Belongs to the sulfur carrier protein TusA family
I6I53_03160	COG4535	Mg2 and Co2 transporter CorC
I6I53_03165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I53_03170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I53_03175	COG3676	manually curated
I6I53_03195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I53_03205	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I53_03210	COG0484	heat shock protein binding
I6I53_03225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I53_03230	COG0598	Magnesium transport protein CorA
I6I53_03235	COG2841	Protein conserved in bacteria
I6I53_03240	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I53_03245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I53_03250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I53_03255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I53_03260	COG1074	ATP-dependent DNA helicase activity
I6I53_03265	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6I53_03290	COG2226	methyltransferase
I6I53_03300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I53_03310	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I53_03325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I53_03325	COG2111	Na H antiporter
I6I53_03330	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I53_03335	COG0651	ATP synthesis coupled electron transport
I6I53_03340	COG1863	multisubunit Na H antiporter MnhE subunit
I6I53_03345	COG2212	antiporter activity
I6I53_03350	COG1320	monovalent cation:proton antiporter activity
I6I53_03365	COG0195	Participates in both transcription termination and antitermination
I6I53_03370	COG0779	Required for maturation of 30S ribosomal subunits
I6I53_03395	COG0149	triose-phosphate isomerase activity
I6I53_03415	COG0237	dephospho-CoA kinase activity
I6I53_03425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I53_03430	COG3123	guanosine phosphorylase activity
I6I53_03435	COG0497	DNA recombination
I6I53_03440	COG1678	Uncharacterized ACR, COG1678
I6I53_03445	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I53_03460	COG1289	transmembrane transporter activity
I6I53_03470	COG1132	(ABC) transporter
I6I53_03480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I53_03480	COG2169	Transcriptional regulator
I6I53_03485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I53_03495	COG0322	excinuclease ABC activity
I6I53_03515	COG1024	Enoyl-CoA hydratase
I6I53_03515	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I53_03525	COG3177	Filamentation induced by cAMP protein fic
I6I53_03530	COG3307	-O-antigen
I6I53_03540	COG3307	-O-antigen
I6I53_03545	COG4969	Belongs to the N-Me-Phe pilin family
I6I53_03620	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6I53_03625	COG1704	LemA family
I6I53_03635	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_03640	COG0477	Major facilitator Superfamily
I6I53_03645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I53_03650	COG1960	acyl-CoA dehydrogenase activity
I6I53_03655	COG0583	DNA-binding transcription factor activity
I6I53_03660	COG0493	'glutamate synthase
I6I53_03665	COG0070	glutamate synthase
I6I53_03665	COG0069	glutamate synthase activity
I6I53_03665	COG0067	glutamate synthase
I6I53_03675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I53_03680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I53_03715	COG2226	methyltransferase
I6I53_03720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I53_03725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I53_03730	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I53_03745	COG0275	rRNA processing
I6I53_03760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I53_03810	COG0488	(ABC) transporter
I6I53_03815	COG0028	Belongs to the TPP enzyme family
I6I53_03825	COG4221	oxidoreductase activity
I6I53_03855	COG0427	acetyl-CoA hydrolase
I6I53_03860	COG0456	acetyltransferase
I6I53_03890	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I53_03895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I53_03905	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I53_03915	COG1132	(ABC) transporter
I6I53_03920	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6I53_03920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I53_03925	COG0531	amino acid
I6I53_03945	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I53_03985	COG3158	transport of potassium into the cell
I6I53_04000	COG2814	Major facilitator Superfamily
I6I53_04010	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I53_04045	COG3706	GGDEF domain
I6I53_04065	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6I53_04075	COG1335	isochorismatase
I6I53_04110	COG1538	Outer membrane efflux protein
I6I53_04135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I53_04140	COG1113	amino acid transport
I6I53_04145	COG0251	oxidation-reduction process
I6I53_04155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I53_04175	COG0277	FAD linked oxidase domain protein
I6I53_04180	COG1304	FMN binding
I6I53_04185	COG2186	Transcriptional regulator
I6I53_04190	COG1620	l-lactate permease
I6I53_04195	COG0583	DNA-binding transcription factor activity
I6I53_04200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I53_04215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I53_04230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I53_04280	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6I53_04285	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I53_04290	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I53_04295	COG1596	polysaccharide export
I6I53_04325	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I53_04345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I53_04375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I53_04380	COG0546	phosphoglycolate phosphatase activity
I6I53_04385	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_04405	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I53_04405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I53_04410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I53_04415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I53_04420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I53_04425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I53_04430	COG1116	anion transmembrane transporter activity
I6I53_04440	COG2233	PERMEase
I6I53_04445	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I53_04450	COG0251	oxidation-reduction process
I6I53_04455	COG1335	isochorismatase
I6I53_04460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I53_04465	COG1309	transcriptional regulator
I6I53_04470	COG0596	Alpha beta hydrolase
I6I53_04485	COG0196	riboflavin kinase activity
I6I53_04490	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I53_04495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I53_04500	COG1047	Peptidyl-prolyl cis-trans
I6I53_04575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I53_04580	COG0657	acetylesterase activity
I6I53_04595	COG0583	DNA-binding transcription factor activity
I6I53_04600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I53_04605	COG0443	Heat shock 70 kDa protein
I6I53_04620	COG2951	lytic endotransglycosylase activity
I6I53_04625	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I53_04640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I53_04665	COG0861	Integral membrane protein TerC family
I6I53_04675	COG0402	S-adenosylhomocysteine deaminase activity
I6I53_04690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I53_04700	COG0706	membrane insertase activity
I6I53_04705	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I53_04710	COG0594	ribonuclease P activity
I6I53_04720	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I53_04725	COG0592	DNA-directed DNA polymerase activity
I6I53_04730	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I53_04735	COG0187	DNA topoisomerase II activity
I6I53_04745	COG0488	(ABC) transporter
I6I53_04765	COG0316	Belongs to the HesB IscA family
I6I53_04770	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6I53_04775	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I53_04810	COG0693	protein deglycase activity
I6I53_04825	COG1012	belongs to the aldehyde dehydrogenase family
I6I53_04830	COG0733	neurotransmitter:sodium symporter activity
I6I53_04840	COG0428	transporter
I6I53_04845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I53_04850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I53_04865	COG1252	NADH dehydrogenase
I6I53_04870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I53_04885	COG2233	PERMEase
I6I53_04890	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6I53_04895	COG1309	transcriptional regulator
I6I53_04900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I53_04915	COG0484	heat shock protein binding
I6I53_04920	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I53_04930	COG2814	Major facilitator Superfamily
I6I53_04935	COG0583	DNA-binding transcription factor activity
I6I53_04945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I53_04950	COG1064	alcohol dehydrogenase
I6I53_04955	COG2818	Glycosylase
I6I53_04985	COG5487	UPF0391 membrane protein
I6I53_04990	COG2983	Belongs to the UPF0260 family
I6I53_05005	COG2133	pyrroloquinoline quinone binding
I6I53_05015	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I53_05020	COG2116	formate transmembrane transporter activity
I6I53_05025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I53_05035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I53_05040	COG1335	isochorismatase
I6I53_05045	COG0385	Bile acid
I6I53_05050	COG2388	GCN5-related N-acetyl-transferase
I6I53_05085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I53_05095	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6I53_05100	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I53_05105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I53_05110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I53_05125	COG0560	Phosphoserine phosphatase
I6I53_05125	COG3830	Belongs to the UPF0237 family
I6I53_05145	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I53_05155	COG0688	phosphatidylethanolamine metabolic process
I6I53_05165	COG0300	oxidoreductase activity
I6I53_05195	COG0534	Mate efflux family protein
I6I53_05200	COG0436	Aminotransferase
I6I53_05205	COG2733	membrane
I6I53_05220	COG2918	glutathione biosynthetic process
I6I53_05235	COG3150	esterase
I6I53_05260	COG4266	Belongs to the allantoicase family
I6I53_05265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I53_05275	COG1247	-acetyltransferase
I6I53_05320	COG0625	glutathione transferase activity
I6I53_05325	COG3706	GGDEF domain
I6I53_05340	COG1393	Belongs to the ArsC family
I6I53_05345	COG0708	Exodeoxyribonuclease III
I6I53_05365	COG0189	ligase activity
I6I53_05370	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I53_05380	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I53_05385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I53_05395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I53_05430	COG2119	membrane
I6I53_05435	COG0426	domain, Protein
I6I53_05435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I53_05460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I53_05480	COG1902	pentaerythritol trinitrate reductase activity
I6I53_05495	COG0668	transmembrane transport
I6I53_05505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I53_05535	COG0004	ammonium transporteR
I6I53_05550	COG0784	Response regulator, receiver
I6I53_05550	COG2205	protein histidine kinase activity
I6I53_05555	COG3162	membrane
I6I53_05560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I53_05575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I53_05595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I53_05620	COG2826	transposase and inactivated derivatives, IS30 family
I6I53_05635	COG2175	clavaminate synthase activity
I6I53_05650	COG0519	Catalyzes the synthesis of GMP from XMP
I6I53_05650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I53_05655	COG3111	PFAM Bacterial OB fold (BOF) protein
I6I53_05660	COG2259	Doxx family
I6I53_05665	COG0586	Pfam SNARE associated Golgi protein
I6I53_05680	COG1192	Involved in chromosome partitioning
I6I53_05745	COG0018	arginyl-trna synthetase
I6I53_05755	COG0281	malic enzyme
I6I53_05760	COG1280	lysine exporter protein (LysE YggA)
I6I53_05765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I53_05770	COG1121	(ABC) transporter
I6I53_05790	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I53_05820	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I53_05825	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I53_05850	COG0386	Belongs to the glutathione peroxidase family
I6I53_05860	COG2814	Major facilitator Superfamily
I6I53_05865	COG1309	transcriptional regulator
I6I53_05870	COG0697	spore germination
I6I53_05910	COG3845	ABC transporter
I6I53_05915	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6I53_05920	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6I53_05925	COG0009	L-threonylcarbamoyladenylate synthase
I6I53_05930	COG0758	DNA mediated transformation
I6I53_05935	COG1652	LysM domain
I6I53_05965	COG1309	transcriptional regulator
I6I53_06015	COG0477	Major facilitator Superfamily
I6I53_06020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I53_06040	COG1253	flavin adenine dinucleotide binding
I6I53_06050	COG2860	membrane
I6I53_06060	COG0477	Major facilitator Superfamily
I6I53_06070	COG0318	PFAM AMP-dependent synthetase and ligase
I6I53_06085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I53_06110	COG0347	Belongs to the P(II) protein family
I6I53_06115	COG0004	ammonium transporteR
I6I53_06120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I53_06125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I53_06125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I53_06160	COG0795	lipopolysaccharide-transporting ATPase activity
I6I53_06165	COG0795	lipopolysaccharide-transporting ATPase activity
I6I53_06170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I53_06175	COG0793	Belongs to the peptidase S41A family
I6I53_06190	COG2197	response regulator
I6I53_06200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6I53_06210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I53_06215	COG4974	Belongs to the 'phage' integrase family
I6I53_06235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I53_06240	COG0772	Belongs to the SEDS family
I6I53_06245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I53_06250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I53_06255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I53_06260	COG0494	nUDIX hydrolase
I6I53_06290	COG3275	phosphorelay sensor kinase activity
I6I53_06300	COG0181	hydroxymethylbilane synthase activity
I6I53_06345	COG1716	ATPase activity
I6I53_06380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I53_06400	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I53_06405	COG0081	regulation of translation
I6I53_06420	COG0085	RNA polymerase activity
I6I53_06425	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I53_06455	COG2826	transposase and inactivated derivatives, IS30 family
I6I53_06470	COG0326	Molecular chaperone. Has ATPase activity
I6I53_06500	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I53_06525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I53_06530	COG1758	RNA polymerase activity
I6I53_06535	COG0194	GDP metabolic process
I6I53_06580	COG0228	four-way junction DNA binding
I6I53_06585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I53_06595	COG0335	large ribosomal subunit rRNA binding
I6I53_06600	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6I53_06605	COG5380	lipid catabolic process
I6I53_06610	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I53_06630	COG5006	permease, DMT superfamily
I6I53_06635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I53_06640	COG0277	FAD linked oxidase domain protein
I6I53_06655	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I53_06660	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I53_06670	COG2814	Major facilitator Superfamily
I6I53_06675	COG1289	transmembrane transporter activity
I6I53_06695	COG0628	permease
I6I53_06700	COG1192	Involved in chromosome partitioning
I6I53_06745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I53_06760	COG0583	DNA-binding transcription factor activity
I6I53_06785	COG0752	glycyl-tRNA synthetase alpha subunit
I6I53_06800	COG0517	IMP dehydrogenase activity
I6I53_06805	COG1983	PspC domain protein
I6I53_06815	COG1960	acyl-CoA dehydrogenase activity
I6I53_06825	COG2885	chlorophyll binding
I6I53_06835	COG0408	coproporphyrinogen oxidase activity
I6I53_06840	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I53_06845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I53_06860	COG0513	Belongs to the DEAD box helicase family
I6I53_06865	COG1127	ABC transporter
I6I53_06870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I53_06890	COG0598	Magnesium transport protein CorA
I6I53_06900	COG0494	nUDIX hydrolase
I6I53_06905	COG1040	competence protein
I6I53_06910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I53_06925	COG2937	Belongs to the GPAT DAPAT family
I6I53_06930	COG1946	Acyl-CoA thioesterase
I6I53_06935	COG1301	dicarboxylic acid transport
I6I53_06950	COG1959	2 iron, 2 sulfur cluster binding
I6I53_06955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I53_06955	COG1017	nitric oxide dioxygenase activity
I6I53_06960	COG0433	COG0433 Predicted ATPase
I6I53_06975	COG0051	transcription antitermination factor activity, RNA binding
I6I53_06980	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I53_06985	COG0088	Forms part of the polypeptide exit tunnel
I6I53_07000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I53_07005	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I53_07015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I53_07025	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I53_07030	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I53_07035	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I53_07040	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I53_07050	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I53_07055	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I53_07065	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I53_07090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I53_07100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I53_07105	COG0202	RNA polymerase activity
I6I53_07110	COG0203	ribosomal protein L17
I6I53_07115	COG2072	flavoprotein involved in K transport
I6I53_07120	COG1960	acyl-CoA dehydrogenase activity
I6I53_07125	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6I53_07155	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6I53_07160	COG0339	signal peptide processing
I6I53_07170	COG0557	exoribonuclease II activity
I6I53_07195	COG5002	protein histidine kinase activity
I6I53_07215	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I53_07225	COG2814	Major facilitator Superfamily
I6I53_07230	COG0583	DNA-binding transcription factor activity
I6I53_07245	COG1295	ribonuclease BN
I6I53_07280	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I53_07285	COG1702	phosphate starvation-inducible protein PhoH
I6I53_07290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I53_07295	COG1196	nuclear chromosome segregation
I6I53_07295	COG0741	lytic transglycosylase activity
I6I53_07295	COG0739	heme binding
I6I53_07305	COG0039	L-malate dehydrogenase activity
I6I53_07325	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I53_07330	COG1183	phosphatidylcholine synthase activity
I6I53_07390	COG2969	positive regulation of protein catabolic process
I6I53_07395	COG0625	glutathione transferase activity
I6I53_07400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I53_07410	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I53_07415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I53_07420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I53_07440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I53_07455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I53_07460	COG1408	metallophosphoesterase
I6I53_07465	COG0477	Major facilitator Superfamily
I6I53_07470	COG1272	protein, Hemolysin III
I6I53_07480	COG2153	protein acetylation
I6I53_07490	COG4667	esterase of the alpha-beta hydrolase superfamily
I6I53_07505	COG0183	Belongs to the thiolase family
I6I53_07520	COG2207	Transcriptional regulator
I6I53_07540	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I53_07550	COG0442	prolyl-tRNA aminoacylation
I6I53_07585	COG0840	transmembrane signaling receptor activity
I6I53_07590	COG0643	Histidine kinase
I6I53_07590	COG2198	Histidine kinase
I6I53_07605	COG1690	Belongs to the RtcB family
I6I53_07610	COG0833	amino acid
I6I53_07615	COG2813	Specifically methylates the guanine in position
I6I53_07620	COG2233	PERMEase
I6I53_07625	COG1217	gtp-binding protein TYPA
I6I53_07630	COG1970	mechanosensitive ion channel activity
I6I53_07645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I53_07650	COG2094	Belongs to the DNA glycosylase MPG family
I6I53_07655	COG4772	TonB-dependent receptor
I6I53_07660	COG1902	pentaerythritol trinitrate reductase activity
I6I53_07695	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6I53_07740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I53_07745	COG0154	amidase activity
I6I53_07750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I53_07755	COG1077	Cell shape determining protein MreB Mrl
I6I53_07760	COG1792	Involved in formation and maintenance of cell shape
I6I53_07770	COG0424	maF-like protein
I6I53_07775	COG1530	ribonuclease E activity
I6I53_07785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I53_07795	COG0560	Phosphoserine phosphatase
I6I53_07810	COG2350	Protein conserved in bacteria
I6I53_07825	COG0583	DNA-binding transcription factor activity
I6I53_07830	COG0667	Aldo Keto reductase
I6I53_07835	COG3781	membrane
I6I53_07840	COG2003	Belongs to the UPF0758 family
I6I53_07845	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I53_07850	COG3783	Cytochrome b(562)
I6I53_07860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I53_07870	COG1162	GTPase activity
I6I53_07875	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I53_07880	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I53_07880	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I53_07885	COG2226	methyltransferase
I6I53_07890	COG1335	isochorismatase
I6I53_07895	COG0857	belongs to the CobB CobQ family
I6I53_07895	COG0280	phosphate acetyltransferase
I6I53_07900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I53_07905	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I53_07910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I53_07925	COG0793	Belongs to the peptidase S41A family
I6I53_07945	COG0105	UTP biosynthetic process
I6I53_07960	COG1426	Protein conserved in bacteria
I6I53_08005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I53_08015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I53_08030	COG2986	histidine ammonia-lyase
I6I53_08050	COG0644	oxidoreductase
I6I53_08060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I53_08070	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_08075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I53_08105	COG1862	Preprotein translocase
I6I53_08115	COG1704	LemA family
I6I53_08125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I53_08140	COG4453	Protein conserved in bacteria
I6I53_08215	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I53_08235	COG2814	Major facilitator Superfamily
I6I53_08245	COG0789	Transcriptional regulator
I6I53_08250	COG0697	spore germination
I6I53_08280	COG3706	GGDEF domain
I6I53_08285	COG2205	protein histidine kinase activity
I6I53_08290	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I53_08305	COG0726	polysaccharide deacetylase
I6I53_08310	COG0438	transferase activity, transferring glycosyl groups
I6I53_08320	COG0438	transferase activity, transferring glycosyl groups
I6I53_08325	COG2826	transposase and inactivated derivatives, IS30 family
I6I53_08340	COG1442	glycosyl transferase family 8
I6I53_08355	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I53_08405	COG1960	acyl-CoA dehydrogenase activity
I6I53_08410	COG1960	acyl-CoA dehydrogenase activity
I6I53_08420	COG2205	protein histidine kinase activity
I6I53_08425	COG0745	RESPONSE REGULATOR receiver
I6I53_08430	COG2315	Protein conserved in bacteria
I6I53_08445	COG3956	TIGRFAM MazG family protein
I6I53_08450	COG1555	photosystem II stabilization
I6I53_08455	COG0617	tRNA 3'-terminal CCA addition
I6I53_08460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I53_08470	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I53_08475	COG1660	Displays ATPase and GTPase activities
I6I53_08480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I53_08485	COG3028	Belongs to the UPF0307 family
I6I53_08490	COG0318	PFAM AMP-dependent synthetase and ligase
I6I53_08495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I53_08510	COG0625	glutathione transferase activity
I6I53_08515	COG1238	metal cluster binding
I6I53_08530	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I53_08555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I53_08560	COG0072	phenylalanine-tRNA ligase activity
I6I53_08565	COG0776	regulation of translation
I6I53_08585	COG0248	Ppx GppA phosphatase
I6I53_08595	COG0037	tRNA processing
I6I53_08635	COG1846	Transcriptional regulator
I6I53_08640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I53_08700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I53_08705	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I53_08715	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I53_08770	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I53_08775	COG1214	PFAM Peptidase M22, glycoprotease
I6I53_08780	COG1968	undecaprenyl-diphosphatase activity
I6I53_08785	COG0742	ribosomal rna small subunit methyltransferase
I6I53_08805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I53_08820	COG2132	Multicopper oxidase
I6I53_08845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I53_08945	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I53_08960	COG0745	RESPONSE REGULATOR receiver
I6I53_08965	COG2205	protein histidine kinase activity
I6I53_08975	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I53_08980	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I53_08985	COG0649	NAD binding
I6I53_08985	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I53_08995	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6I53_09010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I53_09020	COG0713	ATP synthesis coupled electron transport
I6I53_09025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I53_09030	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I53_09040	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I53_09055	COG0583	DNA-binding transcription factor activity
I6I53_09075	COG0668	transmembrane transport
I6I53_09085	COG2081	HI0933 family
I6I53_09090	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I53_09115	COG1280	lysine exporter protein (LysE YggA)
I6I53_09150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I53_09165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I53_09165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I53_09175	COG0489	protein tyrosine kinase activity
I6I53_09180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I53_09195	COG0717	Belongs to the dCTP deaminase family
I6I53_09260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I53_09265	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I53_09270	COG0628	permease
I6I53_09295	COG0583	DNA-binding transcription factor activity
I6I53_09300	COG0697	spore germination
I6I53_09340	COG4983	Phage plasmid primase, P4 family domain protein
I6I53_09350	COG4974	Belongs to the 'phage' integrase family
I6I53_09360	COG0583	DNA-binding transcription factor activity
I6I53_09365	COG0596	Alpha beta hydrolase
I6I53_09385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I53_09390	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I6I53_09395	COG2301	Belongs to the HpcH HpaI aldolase family
I6I53_09400	COG1960	acyl-CoA dehydrogenase activity
I6I53_09410	COG0477	Major facilitator Superfamily
I6I53_09425	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I53_09430	COG4149	molybdate abc transporter
I6I53_09435	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6I53_09440	COG0183	Belongs to the thiolase family
I6I53_09445	COG2031	fatty acid transporter
I6I53_09460	COG0583	DNA-binding transcription factor activity
I6I53_09465	COG2610	gluconate transmembrane transporter activity
I6I53_09470	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_09485	COG1595	DNA-templated transcription, initiation
I6I53_09495	COG1629	transport
I6I53_09510	COG1960	acyl-CoA dehydrogenase activity
I6I53_09520	COG1012	belongs to the aldehyde dehydrogenase family
I6I53_09525	COG1024	Enoyl-CoA hydratase
I6I53_09530	COG2814	Major facilitator Superfamily
I6I53_09540	COG1309	transcriptional regulator
I6I53_09555	COG2072	flavoprotein involved in K transport
I6I53_09560	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6I53_09565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I53_09585	COG1113	amino acid transport
I6I53_09600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I53_09605	COG2267	carboxylic ester hydrolase activity
I6I53_09610	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I53_09635	COG2217	Heavy metal translocating P-type atpase
I6I53_09670	COG4383	Mu-like prophage protein gp29
I6I53_09680	COG5005	Phage virion morphogenesis
I6I53_09695	COG4397	Mu-like prophage major head subunit gpT
I6I53_09765	COG3299	homolog of phage Mu protein gp47
I6I53_09820	COG3079	Belongs to the UPF0149 family
I6I53_09825	COG0006	proline dipeptidase activity
I6I53_09830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I53_09835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I53_09850	COG3107	peptidoglycan biosynthetic process
I6I53_09855	COG0792	nuclease activity
I6I53_09880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I53_09885	COG1388	LysM domain
I6I53_09885	COG0741	lytic transglycosylase activity
I6I53_09885	COG1388	LysM domain
I6I53_09885	COG0741	lytic transglycosylase activity
I6I53_09890	COG4166	transmembrane transport
I6I53_09895	COG4174	ABC transporter (Permease)
I6I53_09900	COG4239	(ABC) transporter, permease
I6I53_09905	COG4172	Belongs to the ABC transporter superfamily
I6I53_09925	COG2351	hydroxyisourate hydrolase activity
I6I53_09935	COG1187	pseudouridine synthase activity
I6I53_09945	COG1823	symporter activity
I6I53_09950	COG0384	phenazine biosynthesis protein PhzF
I6I53_09955	COG0038	chloride channel
I6I53_09960	COG0612	Peptidase, M16
I6I53_10015	COG1522	sequence-specific DNA binding
I6I53_10035	COG1802	Transcriptional regulator
I6I53_10070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I53_10090	COG3676	manually curated
I6I53_10125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I53_10130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I53_10135	COG1045	serine acetyltransferase
I6I53_10150	COG2826	transposase and inactivated derivatives, IS30 family
I6I53_10160	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6I53_10185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I53_10190	COG2239	Acts as a magnesium transporter
I6I53_10200	COG0501	Belongs to the peptidase M48B family
I6I53_10205	COG1196	nuclear chromosome segregation
I6I53_10205	COG0741	lytic transglycosylase activity
I6I53_10205	COG0739	heme binding
I6I53_10210	COG0037	tRNA processing
I6I53_10220	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I53_10225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I53_10235	COG0583	DNA-binding transcription factor activity
I6I53_10245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I53_10245	COG0475	glutathione-regulated potassium exporter activity
I6I53_10280	COG1741	Belongs to the pirin family
I6I53_10290	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I53_10295	COG3739	integral membrane protein
I6I53_10305	COG0586	Pfam SNARE associated Golgi protein
I6I53_10310	COG0302	gtp cyclohydrolase
I6I53_10320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I53_10325	COG3608	succinylglutamate desuccinylase aspartoacylase
I6I53_10325	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6I53_10335	COG0134	indole-3-glycerol-phosphate synthase activity
I6I53_10340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I53_10345	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I53_10350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I53_10355	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I53_10360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I53_10365	COG1067	ATP-dependent peptidase activity
I6I53_10380	COG0254	rRNA binding
I6I53_10385	COG0583	DNA-binding transcription factor activity
I6I53_10390	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6I53_10395	COG4208	sulfate ABC transporter
I6I53_10400	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6I53_10410	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I53_10415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I53_10420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I53_10425	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I53_10435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I53_10440	COG0174	glutamine synthetase
I6I53_10450	COG0481	GTPase activity
I6I53_10455	COG0681	Belongs to the peptidase S26 family
I6I53_10465	COG0571	ribonuclease III activity
I6I53_10470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I53_10480	COG1381	Involved in DNA repair and RecF pathway recombination
I6I53_10485	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I53_10505	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I53_10510	COG1301	dicarboxylic acid transport
I6I53_10530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I53_10535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I53_10560	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I53_10565	COG0826	peptidase U32
I6I53_10570	COG3384	dioxygenase
I6I53_10575	COG1335	isochorismatase
I6I53_10590	COG1720	tRNA m6t6A37 methyltransferase activity
I6I53_10595	COG3706	GGDEF domain
I6I53_10600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I53_10605	COG3111	PFAM Bacterial OB fold (BOF) protein
I6I53_10615	COG0642	Histidine kinase
I6I53_10625	COG0494	nUDIX hydrolase
I6I53_10635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I53_10640	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I53_10645	COG3139	Protein of unknown function (DUF1315)
I6I53_10650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I53_10655	COG1301	dicarboxylic acid transport
I6I53_10665	COG0659	secondary active sulfate transmembrane transporter activity
I6I53_10675	COG2252	PERMEase
I6I53_10680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I53_10695	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I53_10710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I53_10725	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6I53_10730	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I53_10745	COG0667	Aldo Keto reductase
I6I53_10755	COG1765	OsmC-like protein
I6I53_10780	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I53_10780	COG0116	Belongs to the methyltransferase superfamily
I6I53_10785	COG0540	Belongs to the ATCase OTCase family
I6I53_10795	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I53_10800	COG1686	Belongs to the peptidase S11 family
I6I53_10815	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6I53_10825	COG0583	DNA-binding transcription factor activity
I6I53_10840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I53_10845	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I53_10865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I53_10870	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I53_10875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I53_10890	COG4716	Myosin-crossreactive antigen
I6I53_10900	COG3706	GGDEF domain
I6I53_10910	COG1960	acyl-CoA dehydrogenase activity
I6I53_10915	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I53_10935	COG0625	glutathione transferase activity
I6I53_10975	COG0513	Belongs to the DEAD box helicase family
I6I53_10985	COG0778	Nitroreductase
I6I53_11010	COG0167	dihydroorotate dehydrogenase activity
I6I53_11015	COG1286	toxin biosynthetic process
I6I53_11050	COG1610	YqeY-like protein
I6I53_11070	COG0537	adenosine 5'-monophosphoramidase activity
I6I53_11100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I53_11110	COG3100	YcgL domain-containing protein
I6I53_11120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I53_11135	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I53_11140	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I53_11150	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I53_11155	COG1845	cytochrome c oxidase, subunit III
I6I53_11160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I53_11165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I53_11180	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I53_11185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I53_11195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I53_11200	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I53_11215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I53_11220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I53_11255	COG3042	response to heat
I6I53_11260	COG3293	Transposase
I6I53_11265	COG1968	undecaprenyl-diphosphatase activity
I6I53_11290	COG2207	Transcriptional regulator
I6I53_11295	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I53_11305	COG1960	acyl-CoA dehydrogenase activity
I6I53_11310	COG1960	acyl-CoA dehydrogenase activity
I6I53_11335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I53_11345	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6I53_11350	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I53_11355	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6I53_11360	COG2205	protein histidine kinase activity
I6I53_11365	COG0745	RESPONSE REGULATOR receiver
I6I53_11375	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I6I53_11380	COG0477	Major facilitator Superfamily
I6I53_11385	COG0729	surface antigen
I6I53_11430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I53_11440	COG2204	response regulator
I6I53_11445	COG3852	Histidine kinase
I6I53_11455	COG0528	UMP kinase activity
I6I53_11460	COG0233	cytoplasmic translational termination
I6I53_11465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I53_11470	COG0575	Belongs to the CDS family
I6I53_11495	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I53_11505	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I53_11520	COG2137	regulation of response to DNA damage stimulus
I6I53_11530	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I53_11535	COG1011	Hydrolase
I6I53_11540	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6I53_11550	COG3594	Acyltransferase
I6I53_11555	COG0268	Binds directly to 16S ribosomal RNA
I6I53_11560	COG0702	epimerase
I6I53_11565	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I53_11580	COG0069	glutamate synthase activity
I6I53_11585	COG2850	peptidyl-arginine hydroxylation
I6I53_11595	COG0424	maF-like protein
I6I53_11605	COG0126	phosphoglycerate kinase activity
I6I53_11615	COG0191	fructose-bisphosphate aldolase activity
I6I53_11620	COG0697	spore germination
I6I53_11625	COG0778	Nitroreductase
I6I53_11655	COG3698	Phosphodiester glycosidase
I6I53_11665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I53_11670	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6I53_11675	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I53_11675	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I53_11675	COG0506	proline dehydrogenase activity
I6I53_11685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I53_11690	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I53_11695	COG0477	Major facilitator Superfamily
I6I53_11700	COG2267	carboxylic ester hydrolase activity
I6I53_11710	COG1902	pentaerythritol trinitrate reductase activity
I6I53_11710	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I53_11730	COG0504	CTP synthase activity
I6I53_11740	COG0148	phosphopyruvate hydratase activity
I6I53_11750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6I53_11755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I53_11765	COG1116	anion transmembrane transporter activity
I6I53_11765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I53_11770	COG0745	RESPONSE REGULATOR receiver
I6I53_11775	COG2223	nitrite transmembrane transporter activity
I6I53_11780	COG2146	nitrite reductase [NAD(P)H] activity
I6I53_11780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I53_11785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I53_11790	COG0243	molybdopterin cofactor binding
I6I53_11815	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I53_11815	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I53_11820	COG0303	'Molybdopterin
I6I53_11825	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I53_11835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I53_11840	COG0697	spore germination
I6I53_11860	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6I53_11865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I53_11895	COG1960	acyl-CoA dehydrogenase activity
I6I53_11935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I53_11945	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6I53_11950	COG0488	(ABC) transporter
I6I53_11955	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I53_11960	COG0509	glycine decarboxylation via glycine cleavage system
I6I53_11975	COG1132	(ABC) transporter
I6I53_11980	COG0668	transmembrane transport
I6I53_11985	COG3122	Protein conserved in bacteria
I6I53_12000	COG0640	Transcriptional regulator
I6I53_12050	COG1595	DNA-templated transcription, initiation
I6I53_12065	COG1027	Aspartate ammonia-lyase
I6I53_12070	COG0583	DNA-binding transcription factor activity
I6I53_12075	COG1846	Transcriptional regulator
I6I53_12110	COG3676	manually curated
I6I53_12125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I53_12135	COG4993	Dehydrogenase
I6I53_12140	COG3659	wide pore channel activity
I6I53_12145	COG3420	alginic acid biosynthetic process
I6I53_12150	COG0710	3-dehydroquinate dehydratase activity
I6I53_12155	COG3485	protocatechuate 3,4-dioxygenase
I6I53_12160	COG3485	protocatechuate 3,4-dioxygenase
I6I53_12165	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I53_12170	COG2271	Major facilitator Superfamily
I6I53_12175	COG0596	Alpha beta hydrolase
I6I53_12180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I53_12185	COG0183	Belongs to the thiolase family
I6I53_12190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I53_12195	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6I53_12200	COG1414	Transcriptional regulator
I6I53_12205	COG0477	Major facilitator Superfamily
I6I53_12210	COG0583	DNA-binding transcription factor activity
I6I53_12215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I53_12220	COG0235	Class ii aldolase
I6I53_12225	COG1024	Enoyl-CoA hydratase
I6I53_12230	COG1960	acyl-CoA dehydrogenase activity
I6I53_12240	COG2814	Major facilitator Superfamily
I6I53_12250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I53_12260	COG2814	Major facilitator Superfamily
I6I53_12265	COG2814	Major facilitator Superfamily
I6I53_12270	COG1960	acyl-CoA dehydrogenase activity
I6I53_12275	COG1024	Enoyl-CoA hydratase
I6I53_12280	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_12285	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I53_12290	COG0183	Belongs to the thiolase family
I6I53_12305	COG2814	Major facilitator Superfamily
I6I53_12320	COG2814	Major facilitator Superfamily
I6I53_12325	COG0644	oxidoreductase
I6I53_12325	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6I53_12375	COG0583	DNA-binding transcription factor activity
I6I53_12380	COG1380	Effector of murein hydrolase LrgA
I6I53_12385	COG1346	cytolysis
I6I53_12400	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I53_12415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I53_12425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I53_12435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I53_12445	COG3676	manually curated
I6I53_12475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I53_12480	COG2814	Major facilitator Superfamily
I6I53_12485	COG1960	acyl-CoA dehydrogenase activity
I6I53_12490	COG0583	DNA-binding transcription factor activity
I6I53_12500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I53_12505	COG0583	DNA-binding transcription factor activity
I6I53_12510	COG0024	Methionine aminopeptidase
I6I53_12575	COG2814	Major facilitator Superfamily
I6I53_12580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I53_12610	COG0822	iron-sulfur transferase activity
I6I53_12615	COG0316	Belongs to the HesB IscA family
I6I53_12645	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I53_12665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I53_12670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I53_12675	COG1454	alcohol dehydrogenase
I6I53_12680	COG0824	Thioesterase
I6I53_12705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I53_12710	COG2030	dehydratase
I6I53_12715	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_12745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I53_12755	COG3135	benzoate transporter
I6I53_12765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I53_12780	COG0589	response to stress
I6I53_12790	COG0308	aminopeptidase N
I6I53_12805	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6I53_12810	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6I53_12820	COG2826	transposase and inactivated derivatives, IS30 family
I6I53_12830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I53_12835	COG1454	alcohol dehydrogenase
I6I53_12855	COG0505	Belongs to the CarA family
I6I53_12865	COG2353	YceI-like domain
I6I53_12880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I53_12885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I53_12910	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I53_12915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I53_12915	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I53_12925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I53_12985	COG0776	regulation of translation
I6I53_13035	COG4373	Mu-like prophage FluMu protein gp28
I6I53_13050	COG4383	Mu-like prophage protein gp29
I6I53_13055	COG2369	cell adhesion
I6I53_13075	COG4397	Mu-like prophage major head subunit gpT
I6I53_13155	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6I53_13175	COG2193	ferroxidase activity
I6I53_13190	COG0217	transcriptional regulatory protein
I6I53_13205	COG1126	abc transporter atp-binding protein
I6I53_13210	COG0765	amino acid transport
I6I53_13215	COG0765	amino acid transport
I6I53_13240	COG0542	response to heat
I6I53_13245	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I53_13255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I53_13270	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I53_13275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I53_13280	COG0569	domain protein
I6I53_13285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I53_13300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I53_13310	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6I53_13325	COG1294	oxidase, subunit
I6I53_13330	COG4890	Cyd operon protein YbgT
I6I53_13350	COG0552	protein localization to endoplasmic reticulum
I6I53_13385	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I6I53_13390	COG0305	Participates in initiation and elongation during chromosome replication
I6I53_13395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I53_13410	COG1305	Transglutaminase-like
I6I53_13420	COG2308	Evidence 4 Homologs of previously reported genes of
I6I53_13430	COG0445	tRNA wobble uridine modification
I6I53_13455	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6I53_13460	COG0138	bifunctional purine biosynthesis protein purh
I6I53_13470	COG1464	Belongs to the NlpA lipoprotein family
I6I53_13475	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I53_13480	COG2011	ABC-type metal ion transport system permease component
I6I53_13520	COG0515	serine threonine protein kinase
I6I53_13520	COG2815	serine threonine protein kinase
I6I53_13555	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I53_13580	COG0730	response to heat
I6I53_13585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I53_13595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I53_13610	COG1253	flavin adenine dinucleotide binding
I6I53_13630	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I53_13650	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I53_13665	COG0776	regulation of translation
I6I53_13675	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I53_13730	COG0084	hydrolase, TatD family'
I6I53_13750	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I53_13755	COG1132	(ABC) transporter
I6I53_13765	COG0811	peptide transport
I6I53_13770	COG1475	DNA binding
I6I53_13775	COG1192	Involved in chromosome partitioning
I6I53_13780	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I53_13785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I53_13795	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I53_13800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I53_13805	COG1923	regulation of RNA biosynthetic process
I6I53_13810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I53_13815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I53_13820	COG0802	atpase or kinase
I6I53_13825	COG0564	pseudouridine synthase activity
I6I53_13855	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6I53_13865	COG2707	UPF0756 membrane protein
I6I53_13875	COG0583	DNA-binding transcription factor activity
I6I53_13885	COG2814	Major facilitator Superfamily
I6I53_13890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I53_13895	COG0471	metal ion transport
I6I53_13900	COG1012	belongs to the aldehyde dehydrogenase family
I6I53_13925	COG1464	Belongs to the NlpA lipoprotein family
I6I53_13930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I53_13935	COG2011	ABC-type metal ion transport system permease component
I6I53_13940	COG0012	GTP binding
I6I53_13945	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I53_13960	COG1942	4-Oxalocrotonate Tautomerase
I6I53_13965	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I53_13970	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I53_13995	COG0386	Belongs to the glutathione peroxidase family
I6I53_14000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I53_14005	COG0436	Aminotransferase
I6I53_14080	COG3539	Fimbrial protein
I6I53_14090	COG3706	GGDEF domain
I6I53_14115	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I53_14120	COG0596	Alpha beta hydrolase
I6I53_14130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I53_14140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I53_14150	COG0714	Associated with various cellular activities
I6I53_14155	COG2879	small protein
I6I53_14160	COG1966	Carbon starvation protein
I6I53_14165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I53_14170	COG1509	lysine 2,3-aminomutase activity
I6I53_14185	COG4625	pathogenesis
I6I53_14195	COG0602	queuosine metabolic process
I6I53_14200	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I53_14210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I53_14215	COG2353	YceI-like domain
I6I53_14220	COG1051	belongs to the nudix hydrolase family
I6I53_14220	COG1056	cytidyltransferase-related domain
I6I53_14225	COG1024	Enoyl-CoA hydratase
I6I53_14245	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I53_14245	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I53_14255	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I53_14255	COG3008	intermembrane lipid transfer
I6I53_14260	COG2995	paraquat-inducible protein a
I6I53_14285	COG0482	sulfurtransferase activity
I6I53_14290	COG2915	High frequency lysogenization protein hflD homolog
I6I53_14305	COG0616	signal peptide processing
I6I53_14310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I53_14320	COG0573	inorganic phosphate transmembrane transporter activity
I6I53_14325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I53_14330	COG0076	glutamate decarboxylase activity
I6I53_14335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I53_14360	COG1309	transcriptional regulator
I6I53_14365	COG0783	Belongs to the Dps family
I6I53_14375	COG0564	pseudouridine synthase activity
I6I53_14380	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6I53_14390	COG0352	thiamine-phosphate diphosphorylase activity
I6I53_14400	COG1686	Belongs to the peptidase S11 family
I6I53_14410	COG0589	response to stress
I6I53_14420	COG0671	phosphoesterase, PA-phosphatase related
I6I53_14430	COG2194	sulfuric ester hydrolase activity
I6I53_14435	COG0745	RESPONSE REGULATOR receiver
I6I53_14440	COG0642	Histidine kinase
I6I53_14475	COG1131	(ABC) transporter
I6I53_14480	COG0842	Transport permease protein
I6I53_14485	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I53_14485	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I53_14495	COG0772	Belongs to the SEDS family
I6I53_14500	COG2951	lytic endotransglycosylase activity
I6I53_14535	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I53_14540	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I53_14545	COG0024	Methionine aminopeptidase
I6I53_14560	COG2175	clavaminate synthase activity
I6I53_14570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I53_14590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I53_14600	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6I53_14610	COG3293	Transposase
I6I53_14615	COG4122	O-methyltransferase activity
I6I53_14635	COG1137	ATPase activity
I6I53_14640	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6I53_14650	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I53_14670	COG4993	Dehydrogenase
I6I53_14675	COG2175	clavaminate synthase activity
I6I53_14680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I53_14685	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6I53_14690	COG4521	taurine ABC transporter
I6I53_14705	COG2255	four-way junction helicase activity
I6I53_14710	COG0824	Thioesterase
I6I53_14730	COG0823	Involved in the tonB-independent uptake of proteins
I6I53_14750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I53_14770	COG2203	Gaf domain
I6I53_14770	COG4251	negative regulation of phosphorylation
I6I53_14770	COG3706	GGDEF domain
I6I53_14770	COG5001	Diguanylate cyclase
I6I53_14775	COG0418	dihydroorotase activity
I6I53_14780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I53_14790	COG0833	amino acid
I6I53_14800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I53_14805	COG0243	molybdopterin cofactor binding
I6I53_14815	COG1643	Atp-dependent helicase
I6I53_14855	COG3293	Transposase
I6I53_14860	COG3022	response to hydroperoxide
I6I53_14865	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I53_14875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I53_14895	COG1960	acyl-CoA dehydrogenase activity
I6I53_14905	COG2985	domain, Protein
I6I53_14910	COG1764	response to oxidative stress
I6I53_14935	COG0632	four-way junction helicase activity
I6I53_14940	COG4302	ethanolamine ammonia-lyase activity
I6I53_14945	COG4303	Ethanolamine ammonia lyase large subunit
I6I53_14950	COG0531	amino acid
I6I53_14955	COG2070	2-Nitropropane dioxygenase
I6I53_15215	COG5377	YqaJ viral recombinase family
I6I53_15250	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I53_15280	COG2962	Rard protein
I6I53_15285	COG3040	lipid binding
I6I53_15290	COG0556	nucleotide-excision repair
I6I53_15300	COG2199	diguanylate cyclase activity
I6I53_15305	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I53_15315	COG0436	Aminotransferase
I6I53_15330	COG0174	glutamine synthetase
I6I53_15365	COG1484	DNA-dependent DNA replication
I6I53_15370	COG0582	viral genome integration into host DNA
I6I53_15375	COG1074	ATP-dependent DNA helicase activity
I6I53_15395	COG1230	cation diffusion facilitator family transporter
I6I53_15410	COG2814	Major facilitator Superfamily
I6I53_15505	COG0459	protein refolding
I6I53_15510	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I53_15525	COG1597	lipid kinase activity
I6I53_15530	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6I53_15555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I53_15575	COG1929	Belongs to the glycerate kinase type-1 family
I6I53_15595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I53_15600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I53_15605	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6I53_15625	COG0505	Belongs to the CarA family
I6I53_15640	COG0589	response to stress
I6I53_15650	COG0589	response to stress
I6I53_15660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I53_15670	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I53_15675	COG4181	ATPase activity
I6I53_15685	COG0288	reversible hydration of carbon dioxide
I6I53_15700	COG4771	TonB-dependent receptor
I6I53_15725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6I53_15745	COG0306	phosphate transporter
I6I53_15755	COG3586	endonuclease activity
I6I53_15770	COG2223	nitrite transmembrane transporter activity
I6I53_15780	COG2066	Belongs to the glutaminase family
I6I53_15785	COG0242	peptide deformylase activity
I6I53_15790	COG0561	phosphatase activity
I6I53_15805	COG0400	carboxylic ester hydrolase activity
I6I53_15830	COG1215	transferase activity, transferring glycosyl groups
I6I53_15835	COG0726	polysaccharide deacetylase
I6I53_15835	COG1649	PFAM Uncharacterised BCR, COG1649
I6I53_15845	COG2826	transposase and inactivated derivatives, IS30 family
I6I53_15855	COG4681	YaeQ
I6I53_15865	COG0523	cobalamin synthesis protein
I6I53_15880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I53_15880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I53_15900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I53_15915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I53_15920	COG1773	rubredoxin
I6I53_15925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I53_15935	COG0583	DNA-binding transcription factor activity
I6I53_15955	COG1733	regulation of RNA biosynthetic process
I6I53_15965	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I53_15970	COG1648	precorrin-2 dehydrogenase activity
I6I53_15970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I53_15975	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I53_15985	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I53_15995	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I53_16000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I53_16015	COG0671	phosphoesterase, PA-phosphatase related
I6I53_16020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I53_16030	COG1538	Outer membrane efflux protein
I6I53_16035	COG0393	Putative heavy-metal-binding
I6I53_16040	COG0393	Putative heavy-metal-binding
I6I53_16045	COG1028	Short-chain dehydrogenase reductase Sdr
I6I53_16055	COG0525	valine-tRNA ligase activity
I6I53_16080	COG0745	RESPONSE REGULATOR receiver
I6I53_16085	COG2814	Major facilitator Superfamily
I6I53_16095	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I53_16110	COG0142	geranyltranstransferase activity
I6I53_16165	COG3328	transposase activity
I6I53_16170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I53_16230	COG3676	manually curated
I6I53_16235	COG0154	amidase activity
I6I53_16250	COG0431	NADPH-dependent FMN reductase
I6I53_16270	COG1192	Involved in chromosome partitioning
I6I53_16275	COG1475	DNA binding
I6I53_16320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I53_16325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I53_16355	COG4680	protein conserved in bacteria
I6I53_16370	COG1063	alcohol dehydrogenase
I6I53_16390	COG2323	membrane
I6I53_16435	COG2223	nitrite transmembrane transporter activity
I6I53_16440	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6I53_16445	COG1877	trehalose-phosphatase activity
I6I53_16465	COG1570	exodeoxyribonuclease VII activity
I6I53_16560	COG2336	PFAM SpoVT AbrB
I6I53_16565	COG2337	Toxic component of a toxin-antitoxin (TA) module