locus-tag class description URS_0025 ENOG4108XTP Transcriptional regulator URS_0026 ENOG4105H40 URS_0038 ENOG4105MP0 transposase URS_0039 ENOG4105CHR reductase URS_0041 ENOG4108821 RND type efflux pump URS_0043 ENOG4105C59 p-type ATPase URS_0044 ENOG4105W1Y Transcriptional regulator URS_0045 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) URS_0046 ENOG4105C10 Electron transfer flavoprotein URS_0047 ENOG4105BZJ Electron transfer flavoprotein URS_0049 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) URS_0050 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) URS_0051 ENOG4105YYA enhanced serine sensitivity protein SseB URS_0052 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) URS_0053 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) URS_0055 ENOG4105C85 amino acid URS_0056 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) URS_0058 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) URS_0059 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) URS_0060 ENOG4105JQZ Methyltransferase URS_0061 ENOG4105F95 Monooxygenase URS_0066 ENOG4108SC4 )-transporter URS_0067 ENOG4108SC4 )-transporter URS_0068 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase URS_0072 ENOG4105C1G acyl-Coa dehydrogenase URS_0073 ENOG4105EPF Outer membrane porin URS_0075 ENOG4105X58 receptor URS_0076 ENOG4105X58 receptor URS_0078 ENOG4108SF5 RNA Polymerase URS_0079 ENOG4108YNN Heme oxygenase URS_0081 ENOG4105DTD Dehydrogenase URS_0082 ENOG4105CY2 Citrate transporter URS_0083 ENOG4107RSM transcriptional regulator URS_0086 ENOG4105CRW Short chain fatty acid transporter URS_0087 ENOG4105CHU acetyl-coa acetyltransferase URS_0088 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) URS_0089 ENOG4105E0C molybdate abc transporter URS_0090 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein URS_0094 ENOG4105CSH Transporter URS_0095 ENOG4108KB2 LysR family Transcriptional regulator URS_0096 ENOG4105C1G acyl-Coa dehydrogenase URS_0097 ENOG4105CI0 Citrate lyase URS_0098 ENOG4108M9J MaoC like domain protein URS_0100 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 URS_0103 ENOG4105EV9 Alpha Beta Hydrolase URS_0104 ENOG4106NZI LysR family Transcriptional regulator URS_0106 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) URS_0113 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase URS_0114 ENOG4108Q5Y Membrane URS_0115 ENOG4105EGI Transcriptional regulator URS_0121 ENOG4105C02 permease URS_0122 ENOG4105CXB phosphoribosylaminoimidazole synthetase URS_0123 ENOG4108V3E phosphoribosylglycinamide formyltransferase URS_0125 ENOG4105E5H Transposase URS_0136 ENOG4105DHP deoxycytidine triphosphate deaminase URS_0139 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) URS_0140 ENOG4105D1F ATP-binding protein URS_0142 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) URS_0143 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) URS_0147 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) URS_0151 ENOG4105F2W methyltransferase URS_0155 ENOG4105K6H D-cysteine desulfhydrase URS_0156 ENOG4105CBX hi0933 family URS_0161 ENOG4105DP0 ferredoxin-NADP reductase URS_0162 ENOG4105DUM transcriptional regulator, lysR family URS_0165 ENOG4105F9F transposase URS_0166 ENOG4105CNM Receptor URS_0167 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) URS_0169 ENOG4105C8S subunit m URS_0170 ENOG4105D65 subunit l URS_0171 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) URS_0172 ENOG4107UFS subunit j URS_0173 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) URS_0175 ENOG4108IEH NADH dehydrogenase subunit g URS_0176 ENOG4107QIZ NADH dehydrogenase URS_0177 ENOG4105GKE subunit e URS_0178 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) URS_0179 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) URS_0180 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain URS_0182 ENOG4105JJR Histidine kinase URS_0183 ENOG4107EXC regulatoR URS_0184 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) URS_0186 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) URS_0187 ENOG4107QKA exodeoxyribonuclease V beta URS_0192 ENOG4105TW1 Carbohydrate-selective porin OprB URS_0193 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) URS_0196 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) URS_0201 ENOG4105E3B Multicopper oxidase URS_0203 ENOG4105DJV ribulose-phosphate 3-epimerase URS_0207 ENOG4108M3P Membrane URS_0210 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) URS_0211 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) URS_0212 ENOG41072GX Peptidase M22 Glycoprotease URS_0213 ENOG4108Z0R Transferase URS_0224 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) URS_0226 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) URS_0227 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) URS_0240 ENOG4105K56 Transcriptional regulator URS_0241 ENOG4107QHF type ii secretion system protein e URS_0245 ENOG4105C2M dna polymerase I URS_0246 ENOG4108VIA integral membrane protein URS_0247 ENOG4105II7 pyrroline-5-carboxylate reductase URS_0248 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) URS_0250 ENOG4105C9X ppx gppa phosphatase URS_0252 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) URS_0254 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) URS_0255 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) URS_0256 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) URS_0260 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) URS_0261 ENOG41082NX 50s ribosomal protein l35 URS_0264 ENOG4105W39 Membrane URS_0265 ENOG4105CYM Glutathione S-transferase URS_0267 ENOG4105C22 threonyL-tRNA synthetase URS_0271 ENOG4105CEY Amp-dependent synthetase and ligase URS_0272 ENOG4105N42 UPF0307 protein URS_0273 ENOG41080Z8 PHOSPHOCARRIER protein URS_0274 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) URS_0275 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) URS_0277 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase URS_0278 ENOG4105DJ0 Poly(A) Polymerase URS_0279 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein URS_0280 ENOG4105DXN mazG family URS_0283 ENOG4105MSB protein, conserved in bacteria URS_0284 ENOG4105E3W Two component transcriptional regulator (Winged helix family URS_0285 ENOG4105EB3 Histidine kinase URS_0287 ENOG4105CSU acyl-Coa dehydrogenase URS_0288 ENOG4105CSU acyl-Coa dehydrogenase URS_0289 ENOG4108VY7 phosphate-starvation-inducible protein PsiE URS_0295 ENOG4105UGU tonB-dependent Receptor URS_0296 ENOG4105UGU tonB-dependent Receptor URS_0298 ENOG4105C9M aspartyl-trna synthetase URS_0301 ENOG4106AH0 Glycosyl Transferase URS_0302 ENOG4105K64 Glycosyl transferase, family 2 URS_0303 ENOG4108KMV Glycosyl transferase (Group 1 URS_0305 ENOG4107TYR Glycosyl Transferase URS_0306 ENOG4107BJW polysaccharide deacetylase URS_0308 ENOG4105CM2 brancheD-chain amino acid aminotransferase URS_0309 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) URS_0310 ENOG4105BZU Histidine kinase URS_0311 ENOG4105BZU Histidine kinase URS_0312 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH URS_0314 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) URS_0315 ENOG4105W8H transhydrogenase (subunit alpha URS_0316 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) URS_0317 ENOG4106UX7 integral membrane protein URS_0318 ENOG4108Z4X TRANSCRIPTIONal URS_0322 ENOG4105PGM cation diffusion facilitator family transporter URS_0325 ENOG4108ESX Receptor URS_0327 ENOG4105XJC Two component transcriptional regulator (Winged helix family URS_0328 ENOG4105DHQ Histidine kinase URS_0331 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) URS_0336 ENOG4107R3N Filamentation induced by cAMP protein fic URS_0337 ENOG4105DZR Type I site-specific deoxyribonuclease URS_0340 ENOG4105EKX Restriction modification system DNA (Specificity URS_0341 ENOG4105CB5 ATP-dependent DNA helicase recG URS_0342 ENOG4105CVR type I restriction-modification system URS_0359 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) URS_0361 ENOG4108V0P LemA family URS_0363 ENOG4105VIE preprotein translocase, subunit YajC URS_0364 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) URS_0365 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) URS_0369 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) URS_0370 ENOG4105C2D reductase URS_0374 ENOG4105P52 geranylgeranyl reductase URS_0378 ENOG4105C84 Histidine ammonia-lyase URS_0381 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) URS_0384 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) URS_0388 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) URS_0390 ENOG4105CUT histidyl-tRNA synthetase URS_0391 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) URS_0392 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) URS_0395 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) URS_0396 ENOG4105WVQ Fe-S assembly protein IscX URS_0399 ENOG4105CN1 protease URS_0402 ENOG4105DWV Homoserine O-trans-acetylase URS_0403 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) URS_0404 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) URS_0405 ENOG4108DNC Involved in acetate metabolism (By similarity) URS_0406 ENOG4105CHJ isochorismatase hydrolase URS_0408 ENOG4107GFK fumarate URS_0409 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) URS_0410 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) URS_0414 ENOG4108XVM Cytochrome b(562) URS_0415 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase URS_0416 ENOG4105W5Q DNA repair protein (RadC URS_0417 ENOG4105FFC UPF0187 protein URS_0418 ENOG4105CPC Aldo Keto reductase URS_0419 ENOG4105EJC lysr family transcriptional regulator URS_0422 ENOG4105K9H YciI-like protein URS_0425 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein URS_0427 ENOG4105D8T Acyltransferase URS_0429 ENOG4105C03 ribonuclease URS_0430 ENOG4108Z03 MAF-like protein URS_0432 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) URS_0433 ENOG4105DFF Rod shape-determining protein mreb URS_0434 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) URS_0435 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) URS_0436 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) URS_0449 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) URS_0451 ENOG4105T95 Thiol disulfide interChange protein URS_0454 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase URS_0455 ENOG4105CHB tonB-dependent Receptor URS_0456 ENOG4108VX5 3-methyladenine DNA glycosylase URS_0457 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) URS_0458 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) URS_0462 ENOG4105C2W permease URS_0463 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) URS_0464 ENOG4108IQI permease URS_0465 ENOG4105E0Y RtcB Protein URS_0468 ENOG4105CBS Chea signal transduction histidine kinase URS_0469 ENOG4105C8Q Methyl-accepting chemotaxis URS_0470 ENOG4108ZGA chew protein URS_0471 ENOG4105M3Z response regulator URS_0472 ENOG4108UNF response regulator URS_0476 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) URS_0478 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) URS_0479 ENOG4105DZG Dehydrogenase URS_0480 ENOG4105TW1 Carbohydrate-selective porin OprB URS_0482 ENOG4108R6W Transcriptional regulator, ARAC family URS_0485 ENOG4105CHU acetyl-coa acetyltransferase URS_0488 ENOG4108NRW Phospholipase, patatin family URS_0490 ENOG41082BV acetyltransferase URS_0492 ENOG4108UT2 hemolysin iii URS_0493 ENOG4105CSH Transporter URS_0495 ENOG4107RZC phospholipase d URS_0498 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) URS_0502 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) URS_0503 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) URS_0504 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) URS_0506 ENOG4108UJD 30S ribosomal protein S9 URS_0507 ENOG4107MKT Stringent starvation protein a URS_0508 ENOG4105KB2 stringent starvation protein b URS_0520 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase URS_0521 ENOG4105D6S protein involved in catabolism of external DNA URS_0525 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) URS_0527 ENOG4105E4C Lytic transglycosylase catalytic URS_0528 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) URS_0529 ENOG4105C9A Phoh family URS_0530 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) URS_0536 ENOG4105CS1 NAD(P)H quinone oxidoreductase URS_0537 ENOG4107S2Z UPF0761 membrane protein URS_0540 ENOG4106NZI LysR family Transcriptional regulator URS_0541 ENOG4105D94 Major Facilitator Superfamily URS_0542 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase URS_0543 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase URS_0552 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) URS_0554 ENOG4105DGW oligopeptidase A URS_0555 ENOG4105VKU nucleicacid-binding protein URS_0562 ENOG4105C1G acyl-Coa dehydrogenase URS_0563 ENOG4105CT3 Monooxygenase URS_0564 ENOG4108ZT0 50S ribosomal protein l17 URS_0565 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) URS_0566 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) URS_0567 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) URS_0568 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits URS_0569 ENOG41067V7 50S ribosomal protein L36 URS_0570 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) URS_0573 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) URS_0575 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) URS_0576 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) URS_0578 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits URS_0579 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) URS_0580 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) URS_0581 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal URS_0583 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) URS_0585 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) URS_0586 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) URS_0589 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) URS_0590 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) URS_0591 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) URS_0592 ENOG41089BK Glutamine amido-transferase URS_0594 ENOG4105D7A ATP-binding protein URS_0595 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) URS_0596 ENOG4105KPV Transcriptional regulator URS_0599 ENOG4105CK2 sodium dicarboxylate symporter URS_0600 ENOG4105C29 acyl-CoA thioesterase URS_0601 ENOG4105E55 glycerol-3-phosphate acyltransferase URS_0604 ENOG4105CB5 ATP-dependent DNA helicase recG URS_0605 ENOG4105MJ2 Competence protein URS_0606 ENOG4105M6F mutator MutT protein URS_0607 ENOG4108URH decarboxylase URS_0608 ENOG4107QUT magnesium and cobalt transport protein CorA URS_0612 ENOG4105CY3 ABC transporter, permease URS_0613 ENOG4105DHJ ABC, transporter URS_0615 ENOG4105C1J atp-dependent rna helicase URS_0618 ENOG4105ECY inositol monophosphatase URS_0619 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) URS_0620 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) URS_0621 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) URS_0623 ENOG4108ZG0 Ompa motb domain protein URS_0627 ENOG4105CSU acyl-Coa dehydrogenase URS_0629 ENOG41067S9 phage shock protein C, PspC URS_0630 ENOG4105W87 Cbs domain URS_0633 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit URS_0640 ENOG4105C5I Dehydrogenase URS_0650 ENOG4107SKI cobyrinic Acid a,c-diamide synthase URS_0651 ENOG4105IPI Membrane URS_0658 ENOG4105EM2 membrane URS_0659 ENOG4105VCH membrane URS_0660 ENOG4107QF7 multi-drug URS_0662 ENOG4105NF4 modulator of drug activity URS_0663 ENOG4105VRH Antibiotic biosynthesis monooxygenase URS_0666 ENOG4105CQB FAD linked oxidase domain protein URS_0667 ENOG4108JQ1 Dehydrogenase URS_0668 ENOG4107AQZ Membrane URS_0669 ENOG4107AQZ Membrane URS_0672 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) URS_0673 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) URS_0674 ENOG4107IFA Lipase (EC 3.1.1.3) URS_0675 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) URS_0677 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) URS_0678 ENOG4105K5M 30s ribosomal protein S16 URS_0685 ENOG4106855 Competence protein URS_0686 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) URS_0687 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) URS_0688 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) URS_0689 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) URS_0690 ENOG4105KME endoribonuclease L-psp URS_0691 ENOG4105W53 bacterioferritin-associated ferredoxin URS_0692 ENOG4108UQY Iron-storage protein URS_0694 ENOG4107ZXU DSBA oxidoreductase URS_0698 ENOG4105F9F transposase URS_0702 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) URS_0705 ENOG4105C85 amino acid URS_0709 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) URS_0710 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) URS_0713 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) URS_0714 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) URS_0715 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) URS_0716 ENOG4105PM1 preprotein translocase subunit SecE URS_0718 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) URS_0724 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) URS_0725 ENOG4105TV9 FHA Domain-Containing protein URS_0726 ENOG4105GVR general secretion pathway protein D URS_0729 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS URS_0734 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) URS_0735 ENOG4108NEV two component transcriptional regulator, LytTR family URS_0736 ENOG4108HRK Histidine kinase URS_0740 ENOG4108UTW Plays a role in the regulation of phosphate uptake URS_0743 ENOG41087AY ADP-Ribose pyrophosphatase URS_0744 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) URS_0745 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters URS_0746 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) URS_0747 ENOG4105CNI cell division protein FtsW URS_0748 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) URS_0751 ENOG4105CE1 Ferrous iron transport protein b URS_0753 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) URS_0754 ENOG4105T95 Thiol disulfide interChange protein URS_0755 ENOG4105D6E homoserine dehydrogenase URS_0757 ENOG41061WM D-Alanyl-D-Alanine URS_0759 ENOG4107TUY Histidine kinase URS_0760 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family URS_0761 ENOG4105CN1 protease URS_0762 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) URS_0763 ENOG4108K5H permease YjgP YjgQ family protein URS_0764 ENOG4108M8S permease YjgP YjgQ family protein URS_0771 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) URS_0773 ENOG4105BZU Histidine kinase URS_0774 ENOG4105BZU Histidine kinase URS_0778 ENOG4105C0P Mg chelatase subunit ChlI URS_0782 ENOG4105F0N pyrophosphate phospho-hydrolase URS_0785 ENOG4105CEY Amp-dependent synthetase and ligase URS_0786 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) URS_0787 ENOG41079KZ Major Facilitator Superfamily URS_0789 ENOG4105EN6 Membrane URS_0791 ENOG4105EE5 Membrane protein terC URS_0792 ENOG4108URH decarboxylase URS_0795 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) URS_0796 ENOG4105CSH Transporter URS_0799 ENOG4105CCT upf0313 protein URS_0806 ENOG4105Y7M Transcriptional regulator, TetR family URS_0812 ENOG4108WZM domain protein URS_0813 ENOG4105C79 DNA protecting protein DprA URS_0814 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) URS_0816 ENOG4105UIB (ABC) transporter URS_0817 ENOG4108JQ9 ABC transporter URS_0826 ENOG4108IND Tetr family transcriptional regulator URS_0827 ENOG4105F27 Major Facilitator URS_0829 ENOG4108V06 Glutathione peroxidase URS_0832 ENOG4105D5G Transposase URS_0834 ENOG4105DSB aldose 1-epimerase URS_0836 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) URS_0837 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) URS_0842 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) URS_0847 ENOG4105FDK ABC transporter URS_0848 ENOG4105FAV ABC, transporter URS_0849 ENOG410829K Lysine exporter protein (Lyse ygga) URS_0851 ENOG4107R1I NAD-dependent malic enzyme URS_0853 ENOG4105C75 arginyL-tRNA synthetase URS_0858 ENOG4105EUB pirin domain protein URS_0860 ENOG41090R7 Ferric uptake URS_0863 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) URS_0864 ENOG4105H4F exported protein URS_0865 ENOG4108VBZ doxx family URS_0866 ENOG4105DQR SNARE associated Golgi URS_0871 ENOG4107QJE Chromosome Partitioning Protein URS_0880 ENOG4105ZTP Protein of unknown function (DUF1376) URS_0882 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) URS_0897 ENOG4105C0D helicase URS_0899 ENOG4105DM4 PTS System URS_0900 ENOG4105DE4 1-phosphofructokinase URS_0901 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) URS_0909 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein URS_0914 ENOG4105C94 Transporter URS_0917 ENOG4107QN1 sodium solute URS_0918 ENOG41062QD Membrane URS_0919 ENOG4105BZU Histidine kinase URS_0922 ENOG4105BZU Histidine kinase URS_0924 ENOG4108UZX fmn reductase URS_0925 ENOG4105FBW Monooxygenase URS_0926 ENOG4105CNM Receptor URS_0927 ENOG4107T8P acyl-Coa dehydrogenase URS_0929 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) URS_0931 ENOG4105D64 Mechanosensitive ion channel URS_0933 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase URS_0935 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase URS_0937 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) URS_0940 ENOG4105VZ8 Transcriptional regulator URS_0941 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) URS_0942 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) URS_0944 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) URS_0949 ENOG4107QSN dihydrolipoamide acetyltransferase URS_0950 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) URS_0954 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) URS_0955 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) URS_0956 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) URS_0957 ENOG4105CPF Cell wall formation (By similarity) URS_0959 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) URS_0960 ENOG4105D7Z glutathione synthase URS_0965 ENOG4105CGK Exodeoxyribonuclease III URS_0969 ENOG4105BZU Histidine kinase URS_0970 ENOG4107MKT Stringent starvation protein a URS_0971 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) URS_0979 ENOG4108Z7F N-acetyltransferase URS_0981 ENOG41061H0 Monooxygenase URS_0982 ENOG41061H0 Monooxygenase URS_0983 ENOG4105DHG Allantoate amidinohydrolase URS_0984 ENOG4108Z2U ureidoglycolate hydrolase URS_0988 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) URS_0989 ENOG4105IPS esterase URS_0991 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) URS_0992 ENOG4105D9M gamma-glutamylcysteine synthetase URS_0995 ENOG4106BRA Membrane URS_0996 ENOG4105CHM Aminotransferase URS_0997 ENOG4107QJQ Mate efflux family protein URS_1001 ENOG4105CK6 Two component transcriptional regulator (Winged helix family URS_1002 ENOG4105BZU Histidine kinase URS_1004 ENOG4108IXY short-chain dehydrogenase reductase URS_1006 ENOG4105DJ4 phosphatidylserine decarboxylase URS_1007 ENOG4105KHC sulfurtransferase URS_1008 ENOG4107RH7 Nicotinate phosphoribosyltransferase URS_1012 ENOG4105EAC phosphoserine phosphatase URS_1014 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) URS_1015 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) URS_1016 ENOG4107YIM Involved in the transcription termination process (By similarity) URS_1017 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) URS_1018 ENOG4108ZAI phosphatidylglycerophosphatase a URS_1020 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) URS_1023 ENOG4105GQR Chaperone URS_1025 ENOG4105CW0 outer membrane usher protein URS_1026 ENOG4108VCD Chaperone URS_1029 ENOG410830R acetyltransferase URS_1030 ENOG4105C09 Bile acid URS_1031 ENOG4108RWI nicotinamidase URS_1032 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) URS_1034 ENOG4105C8V SAICAR synthetase URS_1036 ENOG4105S64 Formate nitrite transporter URS_1037 ENOG4105D1H recombination factor protein RarA URS_1042 ENOG4108ZZ3 UPF0260 protein URS_1046 ENOG4105CEN a g-specific adenine glycosylase URS_1049 ENOG4108R3E Dna-3-methyladenine glycosylase i URS_1050 ENOG4105DQ4 alcohol dehydrogenase URS_1053 ENOG4105HEI LysR family (Transcriptional regulator URS_1054 ENOG4105F27 Major Facilitator URS_1057 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) URS_1058 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) URS_1061 ENOG4105ENT Efflux transporter rnd family, mfp subunit URS_1062 ENOG4105J7D transcriptional regulator URS_1063 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) URS_1064 ENOG4105C2W permease URS_1067 ENOG4107RP9 extracellular solute-binding protein, family 3 URS_1069 ENOG4105CEP NADH dehydrogenase URS_1072 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) URS_1073 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B URS_1074 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) URS_1076 ENOG4105C8J )-transporter URS_1080 ENOG4107RKG DJ-1/PfpI family URS_1086 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) URS_1091 ENOG4105CBN LysR family transcriptional regulator URS_1092 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ URS_1093 ENOG4105CFG Acts as a chaperone (By similarity) URS_1096 ENOG4105CVE Lytic murein transglycosylase URS_1098 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit URS_1099 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) URS_1102 ENOG4105DFU Cell wall formation (By similarity) URS_1107 ENOG4105DU1 integral membrane protein, terc URS_1109 ENOG4107QUY Guanine deaminase URS_1111 ENOG4108UGV hypoxanthine phosphoribosyltransferase URS_1114 ENOG4105T95 Thiol disulfide interChange protein URS_1116 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins URS_1117 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) URS_1118 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) URS_1119 ENOG4105VG0 50S ribosomal protein l34 URS_1120 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) URS_1121 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) URS_1122 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) URS_1123 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) URS_1125 ENOG4105C5H ABC transporter URS_1126 ENOG4108821 RND type efflux pump URS_1127 ENOG4108821 RND type efflux pump URS_1128 ENOG4108821 RND type efflux pump URS_1129 ENOG4108YX9 iron--sulfur cluster insertion protein erpA URS_1130 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) URS_1131 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) URS_1145 ENOG4105MP0 transposase URS_1148 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase URS_1149 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) URS_1150 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) URS_1151 ENOG4105DTN riboflavin biosynthesis protein ribF URS_1154 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) URS_1155 ENOG4108R86 Transcriptional regulator URS_1156 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) URS_1157 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) URS_1158 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) URS_1159 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) URS_1160 ENOG4105C2W permease URS_1162 ENOG4108VM9 ABC, transporter URS_1163 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component URS_1164 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) URS_1165 ENOG4105GVF (ABC) transporter URS_1166 ENOG4105GVF (ABC) transporter URS_1167 ENOG4107QZM n-acetylglutamate synthase URS_1171 ENOG4105UBK short-chain dehydrogenase reductase URS_1172 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) URS_1173 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) URS_1175 ENOG41062JF Transcriptional regulator URS_1176 ENOG4105EJ2 Transcriptional regulator URS_1179 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) URS_1180 ENOG4105HSS phospholipase C URS_1182 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase URS_1183 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase URS_1184 ENOG4105CJR Integral membrane protein (MviN URS_1186 ENOG4108V1T peptidylprolyl cis-trans isomerase URS_1187 ENOG4108V1T peptidylprolyl cis-trans isomerase URS_1189 ENOG4105D75 Capsular exopolysaccharide family URS_1191 ENOG4105DAY polysaccharide export protein URS_1192 ENOG4107QQG Dehydrogenase URS_1193 ENOG4105C1B dTDP-glucose 4-6-dehydratase URS_1194 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase URS_1195 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) URS_1196 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase URS_1200 ENOG4107J0A lipopolysaccharide biosynthetic process URS_1201 ENOG410650X lipopolysaccharide core region biosynthetic process URS_1202 ENOG4105E2K Glycosyl transferase (Group 1 URS_1203 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) URS_1204 ENOG4105CJT Mannose-1-phosphate guanylyltransferase URS_1206 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase URS_1207 ENOG4105C6Y Udp-glucose 6-dehydrogenase URS_1209 ENOG4105CMR udp-glucose 4-epimerase URS_1210 ENOG4108MRJ URS_1212 ENOG4107QKV phosphomannomutase URS_1214 ENOG4105DAA L-lactate URS_1215 ENOG41073TP transcriptional regulator URS_1216 ENOG4105DMF Dehydrogenase URS_1217 ENOG4105CXG d-lactate dehydrogenase URS_1219 ENOG4105CGF Aromatic amino acid aminotransferase URS_1220 ENOG4105EW9 transcriptional regulator AsnC family URS_1221 ENOG4105MWK D-amino acid dehydrogenase, small subunit URS_1223 ENOG4105M4H endoribonuclease L-psp URS_1224 ENOG4105C85 amino acid URS_1226 ENOG4105F4R Transcriptional regulator mode URS_1229 ENOG4105DFG type I secretion outer membrane protein URS_1236 ENOG4105CHJ isochorismatase hydrolase URS_1237 ENOG4105EUB pirin domain protein URS_1242 ENOG4105BZU Histidine kinase URS_1244 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) URS_1247 ENOG4105RA2 Membrane URS_1249 ENOG4105ETU transcriptional activator (TenA URS_1251 ENOG4107RDB Major Facilitator URS_1252 ENOG4108UUM single-stranded DNA-binding protein URS_1256 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase URS_1272 ENOG4107R3N Filamentation induced by cAMP protein fic URS_1288 ENOG4105NI8 Cytosine-specific methyltransferase URS_1291 ENOG4105DFH Transport of potassium into the cell (By similarity) URS_1298 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) URS_1299 ENOG4105CUV Homoserine Kinase URS_1304 ENOG4105CUB amino acid URS_1305 ENOG4105CJP fad dependent oxidoreductase URS_1306 ENOG4105BZ1 (ABC) transporter URS_1307 ENOG4105CEY Amp-dependent synthetase and ligase URS_1309 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase URS_1311 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) URS_1312 ENOG4105ECC imidazole-glycerol-phosphate dehydratase URS_1318 ENOG4108R6G acetyltransferase URS_1319 ENOG4105CYC Transferase URS_1320 ENOG4105E0F Histidine kinase URS_1321 ENOG4105DPZ Two component transcriptional regulator (Winged helix family URS_1325 ENOG4105PDP Short chain dehydrogenase URS_1327 ENOG4105C7K acetolactate synthase URS_1328 ENOG4105C5H ABC transporter URS_1339 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) URS_1341 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein URS_1342 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) URS_1344 ENOG4105CJN penicillin-binding protein URS_1345 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) URS_1346 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) URS_1347 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) URS_1348 ENOG4105DHI Methyltransferase URS_1349 ENOG4108JQC penicillin-binding protein 1A URS_1354 ENOG4105E4G Type IV pilus URS_1355 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) URS_1356 ENOG4105D49 3-dehydroquinate synthase URS_1358 ENOG4105CBC glutamate synthase URS_1359 ENOG4105BZ8 glutamate synthase URS_1360 ENOG4106NZI LysR family Transcriptional regulator URS_1361 ENOG4105CSU acyl-Coa dehydrogenase URS_1362 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F URS_1363 ENOG4105CSH Transporter URS_1364 ENOG4105CHR reductase URS_1366 ENOG4108V0P LemA family URS_1367 ENOG4105HA9 of methanol dehydrogenase type URS_1380 ENOG4105KHS type IV fimbrial pilin protein URS_1381 ENOG4105KHS type IV fimbrial pilin protein URS_1382 ENOG4105GU8 O-Antigen Polymerase URS_1384 ENOG4108YSG O-Antigen polymerase URS_1385 ENOG4107R3N Filamentation induced by cAMP protein fic URS_1391 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) URS_1393 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase URS_1394 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) URS_1396 ENOG4105BZ1 (ABC) transporter URS_1399 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) URS_1402 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) URS_1403 ENOG4108UJU UPF0301 protein URS_1404 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) URS_1405 ENOG4105NBK UPF0345 protein URS_1406 ENOG4105C2N RNA methyltransferase TrmH family group 3 URS_1408 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) URS_1411 ENOG4107QHF type ii secretion system protein e URS_1412 ENOG4105CP7 Triose-phosphate isomerase URS_1413 ENOG4107EJC Preprotein translocase subunit SecG URS_1417 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) URS_1418 ENOG4105CHV Transcription elongation factor NusA URS_1421 ENOG4105KJM monovalent cation h antiporter subunit g URS_1422 ENOG4105W4C monovalent cation H antiporter subunit F URS_1423 ENOG4105SC1 monovalent cation H antiporter subunit E URS_1424 ENOG4107R4Z monovalent cation h antiporter subunit d URS_1425 ENOG4108ZE9 Monovalent cation H antiporter subunit C URS_1426 ENOG4105D65 subunit l URS_1431 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) URS_1433 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) URS_1435 ENOG4105CSR polyphosphate kinase 2 URS_1438 ENOG4105DSY exodeoxyribonuclease V, gamma URS_1439 ENOG4107QKA exodeoxyribonuclease V beta URS_1441 ENOG4107QYX exodeoxyribonuclease v alpha URS_1443 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) URS_1444 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) URS_1445 ENOG4105Z2P Protein of unknown function (DUF465) URS_1446 ENOG4107QUT magnesium and cobalt transport protein CorA URS_1447 ENOG4107Z6W Protein CrcB homolog URS_1450 ENOG4105DVC DnaJ domain protein URS_1451 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) URS_1453 ENOG4105C25 Primosomal protein n' URS_1454 ENOG4105D7Q type ii secretion system URS_1455 ENOG4108VAU general secretion pathway protein G URS_1457 ENOG4108Z7R Chaperone CsaA URS_1458 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) URS_1459 ENOG4108JU5 Magnesium and cobalt efflux protein URS_1460 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) URS_1463 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase URS_1465 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) URS_1467 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) URS_1468 ENOG4105C5X domain protein URS_1470 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) URS_1472 ENOG4105BZ8 glutamate synthase URS_1475 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) URS_1476 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) URS_1478 ENOG4105NRA 50s ribosomal protein l31 type b URS_1480 ENOG4107T8P acyl-Coa dehydrogenase URS_1483 ENOG4107QI1 Mate efflux family protein URS_1485 ENOG4105CSA Coproporphyrinogen iii oxidase URS_1487 ENOG4108SF5 RNA Polymerase URS_1489 ENOG4105EMU Dehydrogenase URS_1490 ENOG4105CBN LysR family transcriptional regulator URS_1491 ENOG4105D3R alkyl hydroperoxide reductase URS_1495 ENOG4107QQB Ribonuclease E URS_1497 ENOG4105EI2 Pseudouridine synthase URS_1500 ENOG4108W5M transcriptional regulator URS_1503 ENOG4105DZG Dehydrogenase URS_1504 ENOG4105CH6 catalase URS_1506 ENOG4105CSU acyl-Coa dehydrogenase URS_1507 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase URS_1508 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) URS_1515 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) URS_1518 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) URS_1520 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) URS_1522 ENOG4105CHR reductase URS_1523 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) URS_1527 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) URS_1530 ENOG4105CK2 sodium dicarboxylate symporter URS_1531 ENOG4105CPK Glycosyl transferase (Group 1 URS_1532 ENOG4105D1S lipid A biosynthesis URS_1534 ENOG4105C5H ABC transporter URS_1535 ENOG41069P5 Protein slyX homolog URS_1538 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) URS_1543 ENOG4105C4R Atp-dependent dna helicase URS_1547 ENOG4105CKD glutathione-regulated potassium-efflux system protein URS_1548 ENOG4105W0E 50S ribosomal protein L33 URS_1549 ENOG4107RGH Aldehyde dehydrogenase URS_1550 ENOG41062JF Transcriptional regulator URS_1551 ENOG4105CIY formyltetrahydrofolate deformylase URS_1559 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) URS_1562 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) URS_1569 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) URS_1571 ENOG4105DWV Homoserine O-trans-acetylase URS_1572 ENOG4105DWV Homoserine O-trans-acetylase URS_1573 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) URS_1574 ENOG4107E2E PKHD-type hydroxylase URS_1575 ENOG4108ESX Receptor URS_1576 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation URS_1577 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) URS_1582 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) URS_1585 ENOG4105BZU Histidine kinase URS_1586 ENOG4105C6T cysteine synthase URS_1589 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) URS_1593 ENOG4108WBT adenosyltransferase URS_1594 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) URS_1596 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) URS_1603 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) URS_1604 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase URS_1608 ENOG4105D3R alkyl hydroperoxide reductase URS_1609 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving URS_1611 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) URS_1612 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) URS_1617 ENOG4108ZG0 Ompa motb domain protein URS_1618 ENOG4108KHX Diguanylate cyclase URS_1625 ENOG4107QN2 dihydrolipoyl dehydrogenase URS_1627 ENOG4107QPB Beta-lactamase domain protein URS_1630 ENOG4105NAU thioesterase Superfamily protein URS_1634 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) URS_1640 ENOG4105CHU acetyl-coa acetyltransferase URS_1641 ENOG4108WHA ompa motb domain protein URS_1642 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) URS_1645 ENOG4105WD1 Membrane URS_1646 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein URS_1655 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) URS_1657 ENOG4105EM2 membrane URS_1658 ENOG4105C2C drug resistance transporter, Bcr CflA URS_1661 ENOG4105D6U Sodium Glutamate Symporter URS_1662 ENOG4105BZG amino acid carrier protein URS_1663 ENOG4105D78 K07001 NTE family protein URS_1664 ENOG4105D3G Pseudouridine synthase URS_1666 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA URS_1667 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) URS_1668 ENOG4105KWI UPF0339 protein URS_1671 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) URS_1673 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY URS_1674 ENOG4105MJ9 esterase URS_1676 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase URS_1677 ENOG4105HF0 Membrane URS_1679 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) URS_1681 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) URS_1683 ENOG4108UWD Iron-storage protein URS_1684 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen URS_1688 ENOG4105C8Y Acetylornithine aminotransferase URS_1689 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) URS_1690 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) URS_1693 ENOG4105FE9 pseudouridine synthase URS_1694 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) URS_1695 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) URS_1697 ENOG4107RTD sua5 ycio yrdc ywlc family protein URS_1698 ENOG4108BPE -transporting atpase URS_1699 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein URS_1701 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase URS_1702 ENOG4105CHR reductase URS_1704 ENOG4109066 lysm domain bon superfamily protein URS_1705 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF URS_1706 ENOG4105KVH Transcriptional regulator URS_1707 ENOG4105DWF phosphomethylpyrimidine kinase URS_1708 ENOG4107XGZ Hydrolase URS_1710 ENOG4105EXC Acyl-transferase URS_1711 ENOG4108YXA Membrane URS_1716 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) URS_1717 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) URS_1719 ENOG4105KEG ribosomal-protein-alanine acetyltransferase URS_1720 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate URS_1721 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) URS_1723 ENOG4105C3M thioredoxin reductase URS_1724 ENOG4105CNU cell division protein FtsK URS_1725 ENOG4105CSR polyphosphate kinase 2 URS_1729 ENOG4107QMS site-determining protein URS_1730 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) URS_1732 ENOG4106HNH Acyl-transferase URS_1733 ENOG4108ZG0 Ompa motb domain protein URS_1734 ENOG4105C4R Atp-dependent dna helicase URS_1735 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) URS_1736 ENOG4107QKV phosphomannomutase URS_1737 ENOG4105CAS nag kinase URS_1739 ENOG4105E7A Glutamine amidotransferase URS_1742 ENOG4105VDB UPF0125 protein URS_1744 ENOG41090R7 Ferric uptake URS_1745 ENOG4105CZX twitching motility protein URS_1746 ENOG4105CZX twitching motility protein URS_1747 ENOG4105DFA alanine racemase domain protein URS_1748 ENOG4108QM7 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) URS_1752 ENOG4105EYH Exonuclease URS_1753 ENOG4107RH8 nuclease SbcCD subunit D URS_1756 ENOG4105MWK D-amino acid dehydrogenase, small subunit URS_1757 ENOG4105D52 delta-aminolevulinic acid dehydratase URS_1758 ENOG4108VUY thioesterase Superfamily protein URS_1759 ENOG4105CW7 secretion protein, HlyD family URS_1760 ENOG4105C0R drug resistance transporter emrb qaca subfamily URS_1761 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family URS_1768 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase URS_1769 ENOG4106UW1 Major Facilitator superfamily URS_1771 ENOG4105D82 Glutamate dehydrogenase URS_1772 ENOG4105CK2 sodium dicarboxylate symporter URS_1773 ENOG4105CHM Aminotransferase URS_1774 ENOG4105JSC dimethylmenaquinone methyltransferase URS_1781 ENOG4105EYM Major Facilitator superfamily URS_1783 ENOG4105ENJ RND efflux system, outer membrane lipoprotein URS_1784 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) URS_1785 ENOG4105DJY efflux transporter, rnd family, mfp subunit URS_1791 ENOG4105C7K acetolactate synthase URS_1792 ENOG4108ZP8 Acetolactate synthase small subunit URS_1793 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase URS_1794 ENOG4105BZU Histidine kinase URS_1802 ENOG4105MP0 transposase URS_1809 ENOG4105UYK outer membrane protein a URS_1830 ENOG4105DZR Type I site-specific deoxyribonuclease URS_1831 ENOG4107R3N Filamentation induced by cAMP protein fic URS_1838 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) URS_1841 ENOG4105EYA deoxyribonuclease URS_1842 ENOG4107QM5 aconitate hydratase URS_1843 ENOG4105CUZ uba thif-type nad fad binding protein URS_1846 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) URS_1847 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) URS_1852 ENOG4105E3J oxidoreductase URS_1854 ENOG4105D2S major facilitator superfamily URS_1855 ENOG4105D2S major facilitator superfamily URS_1856 ENOG4105EPF Outer membrane porin URS_1857 ENOG41069M3 Transcriptional regulator URS_1861 ENOG4105CHR reductase URS_1863 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase URS_1864 ENOG4105DJB Major Facilitator Superfamily URS_1867 ENOG4105CHR reductase URS_1868 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) URS_1869 ENOG4105C26 Dehydrogenase URS_1870 ENOG4105C7K acetolactate synthase URS_1873 ENOG4105E0A ABC, transporter URS_1874 ENOG4105EHG Permease protein URS_1879 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) URS_1880 ENOG4105C26 Dehydrogenase URS_1881 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) URS_1882 ENOG4105C94 Transporter URS_1886 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit URS_1887 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein URS_1889 ENOG4105E33 succinate dehydrogenase URS_1890 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 URS_1891 ENOG4105C7S Dehydrogenase URS_1892 ENOG4107QN2 dihydrolipoyl dehydrogenase URS_1893 ENOG4105CMV Succinyl-CoA synthetase subunit beta URS_1894 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha URS_1896 ENOG4107BJW polysaccharide deacetylase URS_1897 ENOG4105CND Glycosyl transferase, family 2 URS_1900 ENOG4107S78 Band 7 protein URS_1901 ENOG4105PV3 Inner membrane protein yqiJ URS_1903 ENOG4105CKW Inner membrane protein yedI URS_1904 ENOG4105CGZ zinc metallopeptidase URS_1905 ENOG4105CUB amino acid URS_1906 ENOG4105C0A alcohol dehydrogenase URS_1908 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) URS_1910 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) URS_1913 ENOG4105FQ6 thiopurine methyltransferase URS_1914 ENOG4107T5V SNARE associated Golgi URS_1917 ENOG4105C72 UPF0176 protein URS_1919 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) URS_1921 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) URS_1923 ENOG4105C5T Phosphoribosyl pyrophosphate synthase URS_1931 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) URS_1932 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) URS_1933 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane URS_1934 ENOG4105C34 Pseudouridine synthase URS_1935 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase URS_1937 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) URS_1938 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) URS_1939 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding URS_1943 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) URS_1944 ENOG4105C11 sulfate adenylyltransferase), subunit 2 URS_1945 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) URS_1946 ENOG4105D4T Citrate transporter URS_1951 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase URS_1952 ENOG4105MRR Transcriptional regulator (By similarity) URS_1954 ENOG4108HW3 (ABC) transporter URS_1960 ENOG4105C37 (CBS) domain URS_1962 ENOG4107RET Isocitrate lyase URS_1963 ENOG4105EA8 2-Nitropropane dioxygenase URS_1964 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion URS_1966 ENOG4105CYX Short-chain dehydrogenase reductase Sdr URS_1967 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) URS_1968 ENOG4108YZ9 Urea amidohydrolase subunit gamma URS_1969 ENOG4105KI2 Urea amidohydrolase subunit beta URS_1970 ENOG4105CQM Urea amidohydrolase subunit alpha URS_1971 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) URS_1972 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) URS_1973 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) URS_1978 ENOG4106H78 methyltransferase URS_1979 ENOG4105CJN penicillin-binding protein URS_1982 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) URS_1984 ENOG4105CSM endonuclease III URS_1985 ENOG4108R3D Electron transport complex URS_1986 ENOG4105D82 Glutamate dehydrogenase URS_1988 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b URS_1991 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase URS_1997 ENOG4107KET secretion protein, HlyD family URS_1999 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) URS_2002 ENOG4108UPT UPF0178 protein URS_2006 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) URS_2008 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 URS_2012 ENOG4105C85 amino acid URS_2013 ENOG4105C7F AcnD-accessory protein PrpF URS_2015 ENOG4105CTB Polyprenyl synthetase URS_2018 ENOG4105D78 K07001 NTE family protein URS_2021 ENOG4105EYM Major Facilitator superfamily URS_2022 ENOG4105XJC Two component transcriptional regulator (Winged helix family URS_2023 ENOG4105DHQ Histidine kinase URS_2029 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) URS_2031 ENOG4105CHR reductase URS_2032 ENOG41083I7 UPF0145 protein URS_2033 ENOG4105K8R UPF0145 protein URS_2034 ENOG4105ENJ RND efflux system, outer membrane lipoprotein URS_2035 ENOG4105BZS acriflavin resistance protein URS_2036 ENOG4105C1P efflux transporter, rnd family, mfp subunit URS_2037 ENOG410841Q phosphoesterase PA-phosphatase related protein URS_2040 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) URS_2041 ENOG4105K46 50S ribosomal protein l27 URS_2042 ENOG4105EUB pirin domain protein URS_2043 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) URS_2045 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) URS_2046 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) URS_2047 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) URS_2049 ENOG4105KVH Transcriptional regulator URS_2052 ENOG4105EEQ Na H antiporter URS_2060 ENOG4105C5Q Transcriptional regulator URS_2062 ENOG4107QZF nitrite reductase NADPH large subunit URS_2063 ENOG4105VCQ rubredoxin URS_2065 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) URS_2068 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) URS_2072 ENOG4105C4K Nad synthetase URS_2075 ENOG4105CKI cobalamin synthesis protein URS_2077 ENOG4108VWS Yaeq family URS_2081 ENOG4107BJW polysaccharide deacetylase URS_2082 ENOG4105CND Glycosyl transferase, family 2 URS_2086 ENOG4107XDY Nicotinamide Mononucleotide Transporter URS_2091 ENOG4108HCJ Hydrolase URS_2092 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) URS_2093 ENOG4105CSV Glutaminase URS_2095 ENOG4105EU0 Major facilitator Superfamily URS_2100 ENOG4105WDY DNA (cytosine-5-)-methyltransferase URS_2102 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving URS_2103 ENOG4105C3R Methionine synthase URS_2104 ENOG4105CJ3 phosphate transporter URS_2108 ENOG4105E6M Sulphatase-modifying factor protein URS_2109 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) URS_2112 ENOG4105D05 Receptor URS_2113 ENOG4105D05 Receptor URS_2116 ENOG4108V9Q carbonic anhydrase URS_2117 ENOG4108UJV acyl-CoA thioesterase i URS_2118 ENOG4108I0Y (ABC) transporter URS_2119 ENOG4105CV6 ABC transporter, permease URS_2120 ENOG4107U91 Rhomboid family URS_2121 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase URS_2125 ENOG4107YZX Universal stress protein URS_2128 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain URS_2129 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain URS_2132 ENOG4105HBR Rna-binding protein URS_2133 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) URS_2134 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) URS_2135 ENOG4105EEI dihydropteroate synthase URS_2140 ENOG4105BZW Glycerate kinase URS_2143 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) URS_2146 ENOG4105C6V Glycerol-3-phosphate dehydrogenase URS_2148 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) URS_2152 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) URS_2153 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) URS_2154 ENOG4105C9B Cysteine desulfurase URS_2155 ENOG4105ESN nucleotide-binding protein URS_2156 ENOG4105D7W serine acetyltransferase URS_2158 ENOG4105FDP GntR family transcriptional regulator URS_2159 ENOG4108IYU L-aspartate oxidase URS_2163 ENOG41080IJ Diacylglycerol kinase URS_2165 ENOG4105BZS acriflavin resistance protein URS_2166 ENOG4105CJW magnesium transporter URS_2168 ENOG4105D0M Protease HtpX homolog URS_2169 ENOG4105E4C Lytic transglycosylase catalytic URS_2170 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) URS_2172 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) URS_2173 ENOG4108RRZ Transcription elongation factor GreB URS_2175 ENOG4105DEQ transcriptional regulator URS_2178 ENOG4105CJ1 ABC, transporter URS_2179 ENOG4107QWP ABC-2 type transporter URS_2180 ENOG4107QWP ABC-2 type transporter URS_2182 ENOG4105EJC lysr family transcriptional regulator URS_2183 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) URS_2184 ENOG4105C94 Transporter URS_2186 ENOG4105DVW rieske (2Fe-2S) URS_2187 ENOG4105C26 Dehydrogenase URS_2188 ENOG4105E3J oxidoreductase URS_2190 ENOG4105CKD glutathione-regulated potassium-efflux system protein URS_2192 ENOG4107IIZ CRISPR-associated helicase, Cas3 URS_2193 ENOG4105ENG CRISPR-associated protein, Csy1 family URS_2195 ENOG4105M6W Crispr-associated protein, Csy3 family URS_2196 ENOG4105F9F transposase URS_2235 ENOG4107J0C type IIi URS_2236 ENOG4107QMH DNA methylase URS_2249 ENOG4105C2I pirin domain protein URS_2251 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) URS_2252 ENOG4105NX3 Membrane URS_2254 ENOG4105DQR SNARE associated Golgi URS_2255 ENOG4105EUJ GTP cyclohydrolase i URS_2257 ENOG4105C7W Xanthine dehydrogenase URS_2258 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family URS_2260 ENOG4105F9F transposase URS_2262 ENOG4105DK0 Indole-3-glycerol phosphate synthase URS_2263 ENOG4107QYG anthranilate phosphoribosyltransferase URS_2264 ENOG4105DDQ anthranilate synthase URS_2265 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) URS_2266 ENOG4107QNR UPF0135 protein URS_2267 ENOG4105C0H protease URS_2268 ENOG4105DAN ATP-dependent protease URS_2270 ENOG4105DHU Bile acid URS_2271 ENOG4105VFB Binds the 23S rRNA (By similarity) URS_2272 ENOG4107R11 Transcriptional regulator URS_2273 ENOG4108IJ6 ABC transporter URS_2274 ENOG4105ECW sulfate abc transporter URS_2275 ENOG4108I5D sulfate abc transporter URS_2277 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein URS_2278 ENOG4105YAZ 4-amino-4-deoxychorismate lyase URS_2279 ENOG4105HHA aminodeoxychorismate lyase URS_2280 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) URS_2281 ENOG4108IYU L-aspartate oxidase URS_2282 ENOG4105C0H protease URS_2283 ENOG4105CFQ glutamine synthetase URS_2285 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) URS_2286 ENOG4105C3F Signal peptidase i URS_2288 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) URS_2289 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) URS_2291 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) URS_2292 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) URS_2293 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase URS_2296 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) URS_2298 ENOG4105CK2 sodium dicarboxylate symporter URS_2302 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) URS_2303 ENOG4105NXH GreA GreB family elongation factor URS_2307 ENOG4108JU3 Alkyl hydroperoxide reductase URS_2308 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding URS_2309 ENOG4105CFP Peptidase U32 URS_2310 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b URS_2311 ENOG4105CHJ isochorismatase hydrolase URS_2313 ENOG4105DP0 ferredoxin-NADP reductase URS_2314 ENOG4108R96 Methyltransferase, YaeB family URS_2315 ENOG4105BZU Histidine kinase URS_2316 ENOG4107QHF type ii secretion system protein e URS_2317 ENOG4105H4F exported protein URS_2318 ENOG4105XJC Two component transcriptional regulator (Winged helix family URS_2319 ENOG4105DHQ Histidine kinase URS_2321 ENOG4105M6F mutator MutT protein URS_2323 ENOG4105BZ4 penicillin-binding protein URS_2324 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) URS_2325 ENOG4105VUT cytoplasmic protein URS_2326 ENOG4108I0Q anthranilate phosphoribosyltransferase URS_2327 ENOG4105CK2 sodium dicarboxylate symporter URS_2328 ENOG4105E0K tonB-dependent siderophore receptor URS_2329 ENOG4105CHH sulfate transporter URS_2331 ENOG4105C7N Xanthine uracil vitamin C permease URS_2332 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) URS_2335 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) URS_2337 ENOG4105CFH Aspartokinase URS_2338 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) URS_2339 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase URS_2341 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) URS_2342 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis URS_2345 ENOG4105CPC Aldo Keto reductase URS_2346 ENOG4107RYR Transcriptional regulator, Crp Fnr family URS_2347 ENOG4108UKZ OsmC family URS_2351 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit URS_2353 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) URS_2354 ENOG4105CXT aspartate transcarbamylase URS_2355 ENOG4105CD3 dihydroorotase URS_2360 ENOG4105F1S paraquat-inducible protein a URS_2361 ENOG4105DY2 Paraquat-inducible protein b URS_2363 ENOG4108ETH Formylglycinamide ribotide synthetase URS_2368 ENOG4108UKI Enoyl-CoA hydratase URS_2370 ENOG4108YYC ycei family URS_2371 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen URS_2373 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) URS_2374 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) URS_2379 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein URS_2380 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) URS_2382 ENOG4105D22 carbon starvation protein URS_2383 ENOG4105VCD cytoplasmic protein URS_2384 ENOG4105C7R Atpase associated with various cellular activities aaa_3 URS_2386 ENOG4107Z6I Thiamine biosynthesis protein URS_2387 ENOG4105D7T ABC transporter URS_2388 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component URS_2390 ENOG4105EV9 Alpha Beta Hydrolase URS_2391 ENOG4105WPN DNA integration recombination invertion protein URS_2396 ENOG4105BZU Histidine kinase URS_2402 ENOG4105C0B DNA polymerase III (alpha subunit) URS_2404 ENOG4105CHM Aminotransferase URS_2405 ENOG4105E0X reductase URS_2406 ENOG4108V06 Glutathione peroxidase URS_2407 ENOG4105E7U AraC family transcriptional regulator URS_2412 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) URS_2413 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR URS_2418 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) URS_2419 ENOG4105C3G gtp-binding protein URS_2420 ENOG4108UMI ABC transporter, permease URS_2421 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) URS_2422 ENOG4105D01 (LipO)protein URS_2425 ENOG4107T8P acyl-Coa dehydrogenase URS_2428 ENOG4105F9F transposase URS_2429 ENOG4105C26 Dehydrogenase URS_2430 ENOG4107QPK )-transporter URS_2431 ENOG4105EYW Ion transport protein URS_2432 ENOG4105F27 Major Facilitator URS_2435 ENOG4105DZ2 Transcriptional regulator URS_2436 ENOG4105BZU Histidine kinase URS_2437 ENOG4108VMM UPF0756 membrane protein URS_2439 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) URS_2444 ENOG4105F9F transposase URS_2445 ENOG4105I08 Pseudouridine synthase URS_2448 ENOG4105EI2 Pseudouridine synthase URS_2449 ENOG4105K8N protein family UPF0079, ATPase URS_2450 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) URS_2451 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) URS_2452 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) URS_2453 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) URS_2454 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) URS_2455 ENOG4105EHM Aminoglycoside phosphotransferase URS_2456 ENOG4108S0S Nucleotidyl transferase URS_2457 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) URS_2458 ENOG4107QJE Chromosome Partitioning Protein URS_2459 ENOG4105FA0 parb-like partition protein URS_2462 ENOG4105BZ1 (ABC) transporter URS_2463 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) URS_2465 ENOG4107QRG dna polymerase iii URS_2467 ENOG4105F8V Hydrolase, tatD family URS_2471 ENOG4108WWZ General secretion pathway protein J URS_2472 ENOG4108RTD type II secretion system protein K URS_2476 ENOG4108Z6B deaminase URS_2478 ENOG4105CAT Cytidine monophosphate kinase URS_2479 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) URS_2480 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) URS_2483 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) URS_2485 ENOG4107RN6 Monooxygenase URS_2487 ENOG4105D6Z AFG1 family ATPase URS_2491 ENOG4105EE5 Membrane protein terC URS_2494 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) URS_2496 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) URS_2497 ENOG4107TSN permease URS_2501 ENOG4105CNM Receptor URS_2502 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) URS_2509 ENOG4105D9P serine threonine protein kinase URS_2517 ENOG4108UMI ABC transporter, permease URS_2518 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) URS_2520 ENOG4105C12 Phosphoribosylglycinamide synthetase URS_2521 ENOG4105DC1 bifunctional purine biosynthesis protein purh URS_2522 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) URS_2527 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) URS_2535 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) URS_2536 ENOG4105CDU Replicative dna helicase URS_2538 ENOG4105C2X Arabinose 5-phosphate isomerase URS_2544 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) URS_2549 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii URS_2550 ENOG4105C4M (Ubiquinol oxidase) subunit I URS_2551 ENOG4105PV3 Inner membrane protein yqiJ URS_2555 ENOG4105HDD phospholipase URS_2556 ENOG4105CZN Potassium uptake protein URS_2558 ENOG4105C7B Threonine dehydratase URS_2559 ENOG4105E66 phosphoriboisomerase A URS_2562 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase URS_2564 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) URS_2565 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit URS_2570 ENOG4105EAD ABC transporter URS_2571 ENOG4105DRP amino acid AbC transporter URS_2572 ENOG4105CDA abc transporter atp-binding protein URS_2575 ENOG4105CDY transcriptional regulatory protein URS_2578 ENOG4105E0K tonB-dependent siderophore receptor URS_2579 ENOG4108UQY Iron-storage protein URS_2598 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) URS_2599 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) URS_2600 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) URS_2606 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP URS_2607 ENOG4105CV1 Transketolase (EC 2.2.1.1) URS_2610 ENOG4108YYC ycei family URS_2612 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain URS_2614 ENOG4107RR1 TRANSCRIPTIONal URS_2616 ENOG4105C0A alcohol dehydrogenase URS_2617 ENOG4107QUV Domain protein URS_2619 ENOG4105F4I Transcriptional regulator URS_2620 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase URS_2623 ENOG4105CD8 aminopeptidase N URS_2628 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic URS_2630 ENOG4105DKK Benzoate URS_2631 ENOG4108NIW Leucine export protein LeuE URS_2632 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) URS_2633 ENOG4105DUM transcriptional regulator, lysR family URS_2636 ENOG4105F2M alpha beta hydrolase fold-3 domain protein URS_2638 ENOG4105CHR reductase URS_2644 ENOG4107QMP dna polymerase iii subunits gamma and tau URS_2646 ENOG4105C0A alcohol dehydrogenase URS_2648 ENOG4105D4A Cell wall formation (By similarity) URS_2652 ENOG4108JA2 transcriptioN-repair coupling factor URS_2653 ENOG4108JA2 transcriptioN-repair coupling factor URS_2655 ENOG4105F8J Adenylate Guanylate cyclase URS_2656 ENOG4108ZIT Ferredoxin, 2FE-2S URS_2659 ENOG4108Z4V iron-sulfur cluster assembly URS_2660 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins URS_2662 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family URS_2665 ENOG4105K70 DNA-binding protein URS_2666 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) URS_2667 ENOG4105D8G Major Facilitator superfamily URS_2670 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase URS_2671 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein URS_2678 ENOG4105CWM branched-chain amino acid transport system II carrier protein URS_2679 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) URS_2680 ENOG4105HEI LysR family (Transcriptional regulator URS_2681 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) URS_2683 ENOG4105ETT transcriptional Regulator, LysR family URS_2684 ENOG4105C1G acyl-Coa dehydrogenase URS_2686 ENOG4107RGD Major Facilitator superfamily URS_2687 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F URS_2695 ENOG4105C6T cysteine synthase URS_2697 ENOG4108Z66 YbaK ebsC protein URS_2699 ENOG4107VXZ Hydrolase URS_2701 ENOG4108YZT Adenosylcobinamide kinase URS_2702 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) URS_2705 ENOG41067MG lrgb family URS_2707 ENOG4105DUM transcriptional regulator, lysR family URS_2715 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase URS_2716 ENOG4107RGD Major Facilitator superfamily URS_2719 ENOG4107RGD Major Facilitator superfamily URS_2722 ENOG4105EQ0 Major Facilitator superfamily URS_2725 ENOG4105CHU acetyl-coa acetyltransferase URS_2726 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase URS_2727 ENOG4105CHR reductase URS_2728 ENOG4105E39 Enoyl-CoA hydratase URS_2729 ENOG4105C1G acyl-Coa dehydrogenase URS_2730 ENOG4107RGD Major Facilitator superfamily URS_2731 ENOG4107RGD Major Facilitator superfamily URS_2732 ENOG4107QP7 CoA-transferase subunit A URS_2733 ENOG4105D5G Transposase URS_2735 ENOG4107QNJ CoA-transferase subunit B URS_2739 ENOG4105CSU acyl-Coa dehydrogenase URS_2740 ENOG4108UKI Enoyl-CoA hydratase URS_2741 ENOG4105MP9 class II Aldolase URS_2742 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase URS_2746 ENOG4107HP6 Transcriptional regulator URS_2747 ENOG4107QP7 CoA-transferase subunit A URS_2748 ENOG4107QNJ CoA-transferase subunit B URS_2749 ENOG4105CHU acetyl-coa acetyltransferase URS_2750 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase URS_2751 ENOG4105F2Z 3-oxoadipate enol-lactonase URS_2752 ENOG4105D2S major facilitator superfamily URS_2753 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase URS_2754 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta URS_2755 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha URS_2756 ENOG4105FF2 Type I DHQase URS_2757 ENOG4106JPM 3-dehydroshikimate dehydratase URS_2758 ENOG4105TW1 Carbohydrate-selective porin OprB URS_2765 ENOG4108ZX5 transcriptional regulator URS_2766 ENOG4107RGH Aldehyde dehydrogenase URS_2771 ENOG4105FS7 Transcriptional regulator URS_2772 ENOG4108KB2 LysR family Transcriptional regulator URS_2773 ENOG4108IJ0 Aspartate ammonia-lyase URS_2778 ENOG4105CPQ Dehydrogenase URS_2782 ENOG41080HT Transcriptional regulator, arsr family URS_2785 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme URS_2786 ENOG4105CUY Mechanosensitive ion channel URS_2787 ENOG4105BZ1 (ABC) transporter URS_2789 ENOG4108ZX5 transcriptional regulator URS_2790 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) URS_2791 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) URS_2793 ENOG4105C5H ABC transporter URS_2796 ENOG4107RZC phospholipase d URS_2806 ENOG4105C1G acyl-Coa dehydrogenase URS_2808 ENOG4105F9F transposase URS_2809 ENOG4105DIJ Phosphoethanolamine transferase URS_2814 ENOG4105CMR udp-glucose 4-epimerase URS_2815 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) URS_2819 ENOG4105T38 integral membrane protein URS_2820 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family URS_2822 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein URS_2823 ENOG4105CVM Molybdenum cofactor synthesis domain protein URS_2824 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) URS_2830 ENOG4108IFG nitrite reductase, (NAD(P)H) URS_2831 ENOG4107QZF nitrite reductase NADPH large subunit URS_2832 ENOG4107RNU major facilitator superfamily MFS_1 URS_2833 ENOG4105CK6 Two component transcriptional regulator (Winged helix family URS_2836 ENOG4105MWK D-amino acid dehydrogenase, small subunit URS_2837 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) URS_2838 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) URS_2839 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) URS_2841 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) URS_2845 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase URS_2848 ENOG4105CSH Transporter URS_2849 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) URS_2850 ENOG4105CK7 Sodium proline symporter URS_2851 ENOG4105EW9 transcriptional regulator AsnC family URS_2852 ENOG4105C26 Dehydrogenase URS_2853 ENOG4105YGK Pfam:UPF0157 URS_2854 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) URS_2856 ENOG4108T58 Mg2 transport protein CorA URS_2863 ENOG4108RCM Nitroreductase URS_2865 ENOG4108TZV Membrane URS_2866 ENOG4105D2N Aldolase URS_2868 ENOG4105BZA Phosphoglycerate kinase URS_2870 ENOG4108UHJ MAF-like protein URS_2871 ENOG4107XNU peptidase URS_2872 ENOG4105EZE Cupin 4 family protein URS_2873 ENOG4105CBC glutamate synthase URS_2876 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) URS_2877 ENOG4105K4T epimerase URS_2878 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) URS_2879 ENOG4108TGC Acyltransferase URS_2881 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase URS_2882 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 URS_2883 ENOG4105VEJ Heat shock protein URS_2884 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) URS_2885 ENOG4105Y3E Modulates RecA activity (By similarity) URS_2887 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) URS_2889 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) URS_2891 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane URS_2892 ENOG4105DZP Membrane-associated zinc metalloprotease URS_2894 ENOG4105KNE Phosphatidate cytidylyltransferase URS_2895 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) URS_2896 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) URS_2897 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) URS_2899 ENOG4105CUX Signal transduction histidine kinase URS_2900 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family URS_2902 ENOG4108RVA ribokinase URS_2904 ENOG4105EW9 transcriptional regulator AsnC family URS_2908 ENOG4105D5G Transposase URS_2911 ENOG4107QIJ Aconitate hydratase 2 URS_2916 ENOG4105CFU surface antigen URS_2917 ENOG4107S74 Lysophospholipid transporter LplT URS_2918 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) URS_2920 ENOG4105EEX Two component transcriptional regulator (Winged helix family URS_2921 ENOG4105C08 Histidine kinase URS_2922 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) URS_2923 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) URS_2924 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) URS_2926 ENOG4105KRF dihydroneopterin aldolase URS_2928 ENOG4105D06 uba thif-type nad fad binding protein URS_2932 ENOG4105C1G acyl-Coa dehydrogenase URS_2933 ENOG4105C1G acyl-Coa dehydrogenase URS_2934 ENOG4108MJ3 acetyltransferase URS_2935 ENOG4105EEF Alkane 1-monooxygenase URS_2936 ENOG4105E7U AraC family transcriptional regulator URS_2941 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) URS_2942 ENOG4105UCG Domain of unknown function (DUF333) URS_2948 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) URS_2950 ENOG4108MEJ flavin reductase domain protein URS_2955 ENOG4105GVF (ABC) transporter URS_2956 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component URS_2957 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component URS_2958 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) URS_2959 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) URS_2961 ENOG4105DEN Luciferase family URS_2962 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) URS_2965 ENOG4105E2S oxidase) subunit II URS_2966 ENOG4105BZ9 Cytochrome C oxidase, subunit I URS_2967 ENOG4105CCU oxidase (Subunit III) URS_2968 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) URS_2971 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) URS_2976 ENOG4105VNG YcgL domain-containing protein URS_2978 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) URS_2980 ENOG4105C28 cystathionine URS_2984 ENOG4105K59 histidine triad (HIT) protein URS_2987 ENOG4105VCC 30S ribosomal protein S21 URS_2988 ENOG4105KTH gatB Yqey URS_2990 ENOG4105ERG peptidase m48, ste24p URS_2991 ENOG4105C5I Dehydrogenase URS_2994 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase URS_2996 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) URS_3000 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase URS_3002 ENOG41069NU Nitroreductase URS_3004 ENOG4105C1J atp-dependent rna helicase URS_3005 ENOG4105VEQ Cold shock protein URS_3007 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) URS_3012 ENOG4108K3A Glutathione S-transferase URS_3016 ENOG4105BZU Histidine kinase URS_3017 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) URS_3018 ENOG4107QPN acyl-Coa dehydrogenase URS_3020 ENOG4105BZU Histidine kinase URS_3021 ENOG4105CSH Transporter URS_3026 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) URS_3027 ENOG4105SYT Methylenetetrahydrofolate reductase URS_3028 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) URS_3029 ENOG4105BZU Histidine kinase URS_3030 ENOG4105C6K Malic enzyme URS_3032 ENOG4105M2J Glutaredoxin URS_3033 ENOG4105C8Y Acetylornithine aminotransferase URS_3034 ENOG4105EJC lysr family transcriptional regulator URS_3035 ENOG4108K5P (LipO)protein URS_3036 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) URS_3039 ENOG4105DZ1 carboxypeptidase URS_3040 ENOG4108Z0R Transferase URS_3042 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) URS_3043 ENOG41075W9 High frequency lysogenization protein HflD homolog URS_3044 ENOG4107QTF adenylosuccinate lyase URS_3046 ENOG4105ERU peptidase URS_3047 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) URS_3049 ENOG4105C8U phosphate abc transporter URS_3050 ENOG4105CVA phosphate URS_3051 ENOG4105DY8 decarboxylase URS_3052 ENOG4108JPW Aminotransferase URS_3056 ENOG4105EJ2 Transcriptional regulator URS_3057 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction URS_3058 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) URS_3059 ENOG4105D3G Pseudouridine synthase URS_3060 ENOG4108ZJF Glcg protein URS_3062 ENOG4107S5G Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) URS_3064 ENOG4105DZ1 carboxypeptidase URS_3065 ENOG4108YZY peptidylprolyl cis-trans isomerase URS_3066 ENOG41081QV Universal stress protein URS_3069 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase URS_3071 ENOG4105DIJ Phosphoethanolamine transferase URS_3072 ENOG4105XJC Two component transcriptional regulator (Winged helix family URS_3073 ENOG4105DHQ Histidine kinase URS_3076 ENOG4105D5G Transposase URS_3085 ENOG4107R3N Filamentation induced by cAMP protein fic URS_3087 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 URS_3091 ENOG4108HFV URS_3112 ENOG4105DFP Integrase URS_3114 ENOG4105DA5 (ABC) transporter URS_3115 ENOG4105E3A (ABC) transporter URS_3116 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) URS_3118 ENOG4105CNI cell division protein FtsW URS_3119 ENOG4105CVE Lytic murein transglycosylase URS_3126 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) URS_3127 ENOG4105CE9 30S ribosomal protein S2 URS_3128 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) URS_3132 ENOG4105E2B Taurine dioxygenase URS_3134 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) URS_3135 ENOG4105F8C transglutaminase domain-containing protein URS_3137 ENOG4105E5H Transposase URS_3145 ENOG4106855 Competence protein URS_3147 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) URS_3149 ENOG4108Z4U Ferredoxin URS_3157 ENOG4105DFG type I secretion outer membrane protein URS_3162 ENOG4108IUZ ABC transporter URS_3163 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA URS_3165 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase URS_3166 ENOG4105C2X Arabinose 5-phosphate isomerase URS_3169 ENOG4105DZG Dehydrogenase URS_3170 ENOG4105E2B Taurine dioxygenase URS_3171 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component URS_3172 ENOG4108IY8 ABC, transporter URS_3173 ENOG4106FTQ Taurine ABC transporter, periplasmic URS_3176 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) URS_3177 ENOG4107YD3 Thioesterase URS_3178 ENOG4105E02 MotA TolQ exbB proton channel URS_3179 ENOG4105M8F Biopolymer transport protein exbD tolR URS_3181 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) URS_3182 ENOG4105KCK Peptidoglycan-associated lipoprotein URS_3190 ENOG4105EKE dihydroorotase URS_3191 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) URS_3193 ENOG4108IQI permease URS_3195 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) URS_3196 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit URS_3198 ENOG4105CQ7 ATP-dependent helicase URS_3199 ENOG4105D3R alkyl hydroperoxide reductase URS_3203 ENOG4108JU3 Alkyl hydroperoxide reductase URS_3207 ENOG4105D1Q UPF0246 protein URS_3208 ENOG4105CIN aminoacyl-histidine dipeptidase URS_3210 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase URS_3211 ENOG4105CQC Prephenate dehydratase URS_3214 ENOG4105C1G acyl-Coa dehydrogenase URS_3215 ENOG4105CEB Aspartate aminotransferase URS_3218 ENOG4105EUZ Beta-lactamase domain protein URS_3223 ENOG4108ZHJ Organic hydroperoxide resistance protein URS_3228 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) URS_3229 ENOG4107FQ9 ethanolamine ammonia-lyase URS_3230 ENOG4105CPD ethanolamine ammonia-lyase URS_3231 ENOG4107R55 ethanolamine transporter URS_3233 ENOG4105EA8 2-Nitropropane dioxygenase URS_3235 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) URS_3236 ENOG4107QS8 (LipO)protein URS_3238 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) URS_3243 ENOG4105DTR rard protein URS_3244 ENOG4105QNF Outer membrane lipoprotein URS_3245 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) URS_3247 ENOG4105BZU Histidine kinase URS_3253 ENOG4105C5F glutamine synthetase URS_3258 ENOG4108I0Z Aconitate hydratase URS_3259 ENOG4105BZN citrate synthase URS_3261 ENOG4105CR4 methylisocitrate lyase URS_3262 ENOG4105DRR Transcriptional regulator, GntR family URS_3266 ENOG4108YXU transcriptional regulator AsnC family URS_3278 ENOG4107R4J Chloride channel URS_3279 ENOG4107TIF Phenazine biosynthesis protein, PhzF family URS_3280 ENOG4108ETY sodium dicarboxylate symporter URS_3282 ENOG4108R99 pseudouridine synthase URS_3284 ENOG4105E9K Isocitrate dehydrogenase URS_3285 ENOG4105VT2 5-hydroxyisourate hydrolase URS_3289 ENOG4108JQ5 ABC transporter URS_3290 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component URS_3291 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component URS_3292 ENOG4105E43 Extracellular solute-binding protein, family 5 URS_3293 ENOG4105E9H Lytic Murein transglycosylase URS_3293 ENOG4105E9H Lytic Murein transglycosylase URS_3294 ENOG4107RZZ dna polymerase iii epsilon subunit URS_3296 ENOG4105E09 nadh pyrophosphatase URS_3298 ENOG4105W4M Transport-associated protein URS_3299 ENOG41082RQ UPF0102 protein URS_3300 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) URS_3301 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) URS_3303 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family URS_3304 ENOG4105D0A hydroxylase URS_3305 ENOG4107RAQ aminopeptidase URS_3306 ENOG4105E07 UPF0149 protein URS_3330 ENOG41082YX Transcriptional regulator, arsr family URS_3332 ENOG4105D6J arsenicaL-resistance protein URS_3333 ENOG4105CAU Arsenical resistance protein, ArsH URS_3334 ENOG4105C3M thioredoxin reductase URS_3335 ENOG4105H3G oxidoreductase URS_3337 ENOG41061H0 Monooxygenase URS_3338 ENOG4105SKE transcriptional Regulator LysR family URS_3340 ENOG4105C2W permease URS_3341 ENOG4105DRB nucleoside-specific channel-forming protein URS_3344 ENOG4105RQF LysR family Transcriptional regulator URS_3361 ENOG4105GR3 Histidine kinase URS_3364 ENOG4105E3B Multicopper oxidase URS_3366 ENOG4105CE1 Ferrous iron transport protein b URS_3370 ENOG4108BUD transposase URS_3372 ENOG4105EGS Mechanosensitive ion channel URS_3377 ENOG4105D0M Protease HtpX homolog URS_3386 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit URS_3390 ENOG4105H3G oxidoreductase URS_3397 ENOG4108JUA Transcriptional regulator URS_3405 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family URS_3407 ENOG4105CJP fad dependent oxidoreductase URS_3408 ENOG4105C85 amino acid URS_3409 ENOG4108594 Permease of the drug metabolite transporter URS_3411 ENOG4108C66 Inherit from COG: DNA primase URS_3415 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) URS_3416 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) URS_3418 ENOG4105D5G Transposase URS_3421 ENOG4105D5G Transposase URS_3426 ENOG4105MZU cell filamentation protein URS_3432 ENOG4105G6Z alkaline phosphatase URS_3439 ENOG4107SKI cobyrinic Acid a,c-diamide synthase URS_3442 ENOG4108WQI RNA Polymerase URS_3444 ENOG4105E18 UPF0276 protein URS_3456 ENOG4108I6A alcohol dehydrogenase URS_3459 ENOG4105C26 Dehydrogenase URS_3460 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase URS_3462 ENOG4108WUH Transcriptional regulator, TetR family URS_3463 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein URS_3465 ENOG4108ZHJ Organic hydroperoxide resistance protein URS_3466 ENOG4105K56 Transcriptional regulator