locus-tag	class	description
URS_0036	COG2801	Transposase and inactivated derivatives
URS_0037	COG2801	Transposase and inactivated derivatives
URS_0039	COG1028	Short-chain dehydrogenase reductase Sdr
URS_0043	COG2217	Heavy metal translocating P-type atpase
URS_0050	COG2267	carboxylic ester hydrolase activity
URS_0052	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
URS_0055	COG1113	amino acid transport
URS_0059	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
URS_0060	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
URS_0061	COG2072	flavoprotein involved in K transport
URS_0064	COG1309	transcriptional regulator
URS_0066	COG2814	Major facilitator Superfamily
URS_0067	COG2814	Major facilitator Superfamily
URS_0068	COG1024	Enoyl-CoA hydratase
URS_0069	COG1012	belongs to the aldehyde dehydrogenase family
URS_0072	COG1960	acyl-CoA dehydrogenase activity
URS_0075	COG1629	transport
URS_0076	COG1629	transport
URS_0078	COG1595	DNA-templated transcription, initiation
URS_0081	COG1028	Short-chain dehydrogenase reductase Sdr
URS_0082	COG2610	gluconate transmembrane transporter activity
URS_0083	COG0583	DNA-binding transcription factor activity
URS_0086	COG2031	fatty acid transporter
URS_0088	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
URS_0089	COG4149	molybdate abc transporter
URS_0090	COG0725	ABC transporter, periplasmic molybdate-binding protein
URS_0094	COG0477	Major facilitator Superfamily
URS_0095	COG0583	DNA-binding transcription factor activity
URS_0096	COG1960	acyl-CoA dehydrogenase activity
URS_0097	COG2301	Belongs to the HpcH HpaI aldolase family
URS_0098	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
URS_0103	COG0596	Alpha beta hydrolase
URS_0104	COG0583	DNA-binding transcription factor activity
URS_0106	COG4974	Belongs to the 'phage' integrase family
URS_0113	COG1902	pentaerythritol trinitrate reductase activity
URS_0113	COG0446	pyridine nucleotide-disulphide oxidoreductase
URS_0114	COG0697	spore germination
URS_0115	COG0583	DNA-binding transcription factor activity
URS_0121	COG0628	permease
URS_0122	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
URS_0123	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
URS_0125	COG4372	Transposase
URS_0136	COG0717	Belongs to the dCTP deaminase family
URS_0139	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
URS_0140	COG0489	protein tyrosine kinase activity
URS_0142	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
URS_0142	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
URS_0143	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
URS_0150	COG1280	lysine exporter protein (LysE YggA)
URS_0151	COG2226	methyltransferase
URS_0155	COG2515	1-aminocyclopropane-1-carboxylate deaminase
URS_0156	COG2081	HI0933 family
URS_0158	COG0668	transmembrane transport
URS_0162	COG0583	DNA-binding transcription factor activity
URS_0165	COG2826	transposase and inactivated derivatives, IS30 family
URS_0167	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
URS_0169	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
URS_0170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
URS_0171	COG0713	ATP synthesis coupled electron transport
URS_0173	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
URS_0176	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
URS_0178	COG0649	NAD binding
URS_0178	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
URS_0179	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
URS_0180	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
URS_0182	COG2205	protein histidine kinase activity
URS_0183	COG0745	RESPONSE REGULATOR receiver
URS_0184	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
URS_0184	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
URS_0186	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
URS_0187	COG1074	ATP-dependent DNA helicase activity
URS_0189	COG2801	Transposase and inactivated derivatives
URS_0196	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
URS_0201	COG2132	Multicopper oxidase
URS_0203	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
URS_0207	COG4269	membrane
URS_0210	COG0742	ribosomal rna small subunit methyltransferase
URS_0211	COG1968	undecaprenyl-diphosphatase activity
URS_0212	COG1214	PFAM Peptidase M22, glycoprotease
URS_0224	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
URS_0226	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
URS_0227	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
URS_0239	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
URS_0240	COG1846	Transcriptional regulator
URS_0248	COG0037	tRNA processing
URS_0254	COG0776	regulation of translation
URS_0255	COG0072	phenylalanine-tRNA ligase activity
URS_0256	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
URS_0260	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
URS_0261	COG0291	Belongs to the bacterial ribosomal protein bL35 family
URS_0264	COG1238	metal cluster binding
URS_0265	COG0625	glutathione transferase activity
URS_0267	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
URS_0271	COG0318	PFAM AMP-dependent synthetase and ligase
URS_0272	COG3028	Belongs to the UPF0307 family
URS_0273	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
URS_0274	COG1660	Displays ATPase and GTPase activities
URS_0275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
URS_0277	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
URS_0278	COG0617	tRNA 3'-terminal CCA addition
URS_0279	COG1555	photosystem II stabilization
URS_0280	COG3956	TIGRFAM MazG family protein
URS_0283	COG2315	Protein conserved in bacteria
URS_0284	COG0745	RESPONSE REGULATOR receiver
URS_0285	COG2205	protein histidine kinase activity
URS_0287	COG1960	acyl-CoA dehydrogenase activity
URS_0288	COG1960	acyl-CoA dehydrogenase activity
URS_0289	COG3223	Belongs to the PsiE family
URS_0298	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
URS_0301	COG1442	glycosyl transferase family 8
URS_0302	COG1216	Glycosyl transferase, family 2
URS_0303	COG0438	transferase activity, transferring glycosyl groups
URS_0305	COG0438	transferase activity, transferring glycosyl groups
URS_0306	COG0726	polysaccharide deacetylase
URS_0309	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
URS_0310	COG2205	protein histidine kinase activity
URS_0311	COG3706	GGDEF domain
URS_0314	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
URS_0315	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
URS_0316	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
URS_0317	COG0697	spore germination
URS_0318	COG0789	Transcriptional regulator
URS_0320	COG2814	Major facilitator Superfamily
URS_0322	COG1230	cation diffusion facilitator family transporter
URS_0325	COG4774	siderophore transport
URS_0327	COG0745	RESPONSE REGULATOR receiver
URS_0331	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
URS_0337	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
URS_0340	COG0732	type I restriction modification DNA specificity domain
URS_0342	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
URS_0359	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
URS_0361	COG1704	LemA family
URS_0363	COG1862	Preprotein translocase
URS_0369	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
URS_0370	COG1028	Short-chain dehydrogenase reductase Sdr
URS_0374	COG0644	oxidoreductase
URS_0378	COG2986	histidine ammonia-lyase
URS_0383	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
URS_0384	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
URS_0390	COG0124	histidyl-tRNA synthetase
URS_0391	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
URS_0392	COG1426	Protein conserved in bacteria
URS_0395	COG0105	UTP biosynthetic process
URS_0399	COG0793	Belongs to the peptidase S41A family
URS_0402	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
URS_0403	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
URS_0404	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
URS_0405	COG0280	phosphate acetyltransferase
URS_0405	COG0857	belongs to the CobB CobQ family
URS_0406	COG1335	isochorismatase
URS_0408	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
URS_0408	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
URS_0409	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
URS_0410	COG1162	GTPase activity
URS_0412	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
URS_0414	COG3783	Cytochrome b(562)
URS_0415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
URS_0416	COG2003	Belongs to the UPF0758 family
URS_0417	COG3781	membrane
URS_0418	COG0667	Aldo Keto reductase
URS_0419	COG0583	DNA-binding transcription factor activity
URS_0422	COG2350	Protein conserved in bacteria
URS_0425	COG0560	Phosphoserine phosphatase
URS_0427	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
URS_0429	COG1530	ribonuclease E activity
URS_0430	COG0424	maF-like protein
URS_0432	COG1792	Involved in formation and maintenance of cell shape
URS_0433	COG1077	Cell shape determining protein MreB Mrl
URS_0434	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
URS_0435	COG0154	amidase activity
URS_0436	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
URS_0446	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
URS_0449	COG0354	folic acid binding
URS_0451	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
URS_0454	COG1902	pentaerythritol trinitrate reductase activity
URS_0455	COG4772	TonB-dependent receptor
URS_0456	COG2094	Belongs to the DNA glycosylase MPG family
URS_0457	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
URS_0462	COG2233	PERMEase
URS_0463	COG2813	Specifically methylates the guanine in position
URS_0464	COG0833	amino acid
URS_0465	COG1690	Belongs to the RtcB family
URS_0468	COG0643	Histidine kinase
URS_0468	COG2198	Histidine kinase
URS_0469	COG0840	transmembrane signaling receptor activity
URS_0476	COG0442	prolyl-tRNA aminoacylation
URS_0478	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
URS_0482	COG2207	Transcriptional regulator
URS_0485	COG0183	Belongs to the thiolase family
URS_0488	COG4667	esterase of the alpha-beta hydrolase superfamily
URS_0490	COG2153	protein acetylation
URS_0492	COG1272	protein, Hemolysin III
URS_0493	COG0477	Major facilitator Superfamily
URS_0494	COG1408	metallophosphoesterase
URS_0495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
URS_0498	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
URS_0502	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
URS_0503	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
URS_0504	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
URS_0506	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
URS_0507	COG0625	glutathione transferase activity
URS_0508	COG2969	positive regulation of protein catabolic process
URS_0520	COG1183	phosphatidylcholine synthase activity
URS_0521	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
URS_0525	COG0039	L-malate dehydrogenase activity
URS_0527	COG1196	nuclear chromosome segregation
URS_0527	COG0741	lytic transglycosylase activity
URS_0527	COG0739	heme binding
URS_0528	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
URS_0529	COG1702	phosphate starvation-inducible protein PhoH
URS_0530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
URS_0537	COG1295	ribonuclease BN
URS_0540	COG0583	DNA-binding transcription factor activity
URS_0541	COG2814	Major facilitator Superfamily
URS_0543	COG0179	Fumarylacetoacetate (FAA) hydrolase
URS_0552	COG0557	exoribonuclease II activity
URS_0554	COG0339	signal peptide processing
URS_0555	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
URS_0561	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
URS_0562	COG1960	acyl-CoA dehydrogenase activity
URS_0563	COG2072	flavoprotein involved in K transport
URS_0564	COG0203	ribosomal protein L17
URS_0565	COG0202	RNA polymerase activity
URS_0566	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
URS_0567	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
URS_0568	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
URS_0569	COG0257	Belongs to the bacterial ribosomal protein bL36 family
URS_0573	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
URS_0575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
URS_0576	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
URS_0578	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
URS_0579	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
URS_0580	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
URS_0581	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
URS_0583	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
URS_0585	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
URS_0586	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
URS_0589	COG0088	Forms part of the polypeptide exit tunnel
URS_0590	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
URS_0591	COG0051	transcription antitermination factor activity, RNA binding
URS_0594	COG0433	COG0433 Predicted ATPase
URS_0595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
URS_0595	COG1017	nitric oxide dioxygenase activity
URS_0596	COG1959	2 iron, 2 sulfur cluster binding
URS_0599	COG1301	dicarboxylic acid transport
URS_0600	COG1946	Acyl-CoA thioesterase
URS_0601	COG2937	Belongs to the GPAT DAPAT family
URS_0604	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
URS_0605	COG1040	competence protein
URS_0606	COG0494	nUDIX hydrolase
URS_0608	COG0598	Magnesium transport protein CorA
URS_0612	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
URS_0613	COG1127	ABC transporter
URS_0615	COG0513	Belongs to the DEAD box helicase family
URS_0619	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
URS_0620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
URS_0621	COG0408	coproporphyrinogen oxidase activity
URS_0623	COG2885	chlorophyll binding
URS_0627	COG1960	acyl-CoA dehydrogenase activity
URS_0629	COG1983	PspC domain protein
URS_0630	COG0517	IMP dehydrogenase activity
URS_0633	COG0752	glycyl-tRNA synthetase alpha subunit
URS_0637	COG0583	DNA-binding transcription factor activity
URS_0640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
URS_0650	COG1192	Involved in chromosome partitioning
URS_0651	COG0628	permease
URS_0653	COG3293	Transposase
URS_0655	COG2801	Transposase and inactivated derivatives
URS_0656	COG2963	transposase activity
URS_0658	COG1289	transmembrane transporter activity
URS_0659	COG2814	Major facilitator Superfamily
URS_0662	COG2249	NAD(P)H dehydrogenase (quinone) activity
URS_0663	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
URS_0666	COG0277	FAD linked oxidase domain protein
URS_0667	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
URS_0668	COG5006	permease, DMT superfamily
URS_0669	COG5006	permease, DMT superfamily
URS_0672	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
URS_0673	COG5380	lipid catabolic process
URS_0674	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
URS_0675	COG0335	large ribosomal subunit rRNA binding
URS_0677	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
URS_0678	COG0228	four-way junction DNA binding
URS_0685	COG4968	Prepilin-type N-terminal cleavage methylation domain
URS_0686	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
URS_0687	COG0194	GDP metabolic process
URS_0688	COG1758	RNA polymerase activity
URS_0689	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
URS_0691	COG2906	2 iron, 2 sulfur cluster binding
URS_0694	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
URS_0698	COG2826	transposase and inactivated derivatives, IS30 family
URS_0702	COG0326	Molecular chaperone. Has ATPase activity
URS_0709	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
URS_0710	COG0085	RNA polymerase activity
URS_0713	COG0081	regulation of translation
URS_0714	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
URS_0718	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
URS_0725	COG1716	ATPase activity
URS_0734	COG0181	hydroxymethylbilane synthase activity
URS_0736	COG3275	phosphorelay sensor kinase activity
URS_0743	COG0494	nUDIX hydrolase
URS_0744	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
URS_0745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
URS_0746	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
URS_0747	COG0772	Belongs to the SEDS family
URS_0748	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
URS_0753	COG4974	Belongs to the 'phage' integrase family
URS_0754	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
URS_0756	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
URS_0758	COG2197	response regulator
URS_0761	COG0793	Belongs to the peptidase S41A family
URS_0762	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
URS_0763	COG0795	lipopolysaccharide-transporting ATPase activity
URS_0764	COG0795	lipopolysaccharide-transporting ATPase activity
URS_0771	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
URS_0771	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
URS_0773	COG0004	ammonium transporteR
URS_0774	COG0004	ammonium transporteR
URS_0775	COG0347	Belongs to the P(II) protein family
URS_0778	COG0606	chelatase, subunit chli
URS_0782	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
URS_0785	COG0318	PFAM AMP-dependent synthetase and ligase
URS_0787	COG0477	Major facilitator Superfamily
URS_0789	COG2860	membrane
URS_0791	COG1253	flavin adenine dinucleotide binding
URS_0795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
URS_0796	COG0477	Major facilitator Superfamily
URS_0806	COG1309	transcriptional regulator
URS_0812	COG1652	LysM domain
URS_0813	COG0758	DNA mediated transformation
URS_0814	COG0009	L-threonylcarbamoyladenylate synthase
URS_0825	COG0697	spore germination
URS_0826	COG1309	transcriptional regulator
URS_0827	COG2814	Major facilitator Superfamily
URS_0829	COG0386	Belongs to the glutathione peroxidase family
URS_0832	COG3328	transposase activity
URS_0836	COG0355	proton-transporting ATP synthase activity, rotational mechanism
URS_0837	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
URS_0847	COG1121	(ABC) transporter
URS_0848	COG1108	ABC-type Mn2 Zn2 transport systems permease components
URS_0849	COG1280	lysine exporter protein (LysE YggA)
URS_0850	COG3501	Rhs element vgr protein
URS_0851	COG0281	malic enzyme
URS_0853	COG0018	arginyl-trna synthetase
URS_0863	COG0518	GMP synthase (glutamine-hydrolyzing) activity
URS_0863	COG0519	Catalyzes the synthesis of GMP from XMP
URS_0864	COG3111	PFAM Bacterial OB fold (BOF) protein
URS_0865	COG2259	Doxx family
URS_0866	COG0586	Pfam SNARE associated Golgi protein
URS_0871	COG1192	Involved in chromosome partitioning
URS_0880	COG3756	Protein conserved in bacteria
URS_0882	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
URS_0885	COG0753	catalase activity
URS_0896	COG3550	peptidyl-serine autophosphorylation
URS_0897	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
URS_0899	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
URS_0899	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
URS_0899	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
URS_0900	COG1105	Belongs to the carbohydrate kinase PfkB family
URS_0901	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
URS_0901	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
URS_0904	COG4716	Myosin-crossreactive antigen
URS_0909	COG2249	NAD(P)H dehydrogenase (quinone) activity
URS_0914	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
URS_0917	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
URS_0918	COG3162	membrane
URS_0919	COG0784	Response regulator, receiver
URS_0919	COG2205	protein histidine kinase activity
URS_0922	COG0004	ammonium transporteR
URS_0929	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
URS_0931	COG0668	transmembrane transport
URS_0933	COG1519	Transferase
URS_0935	COG1902	pentaerythritol trinitrate reductase activity
URS_0937	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
URS_0940	COG1476	TRANSCRIPTIONal
URS_0941	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
URS_0942	COG0259	pyridoxamine-phosphate oxidase activity
URS_0946	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
URS_0946	COG0426	domain, Protein
URS_0947	COG2119	membrane
URS_0954	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
URS_0956	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
URS_0957	COG1181	Belongs to the D-alanine--D-alanine ligase family
URS_0959	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
URS_0960	COG0189	ligase activity
URS_0965	COG0708	Exodeoxyribonuclease III
URS_0969	COG3706	GGDEF domain
URS_0970	COG0625	glutathione transferase activity
URS_0979	COG1247	-acetyltransferase
URS_0981	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
URS_0982	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
URS_0983	COG4266	Belongs to the allantoicase family
URS_0984	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
URS_0989	COG3150	esterase
URS_0991	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
URS_0992	COG2918	glutathione biosynthetic process
URS_0995	COG2733	membrane
URS_0996	COG0436	Aminotransferase
URS_0997	COG0534	Mate efflux family protein
URS_1004	COG0300	oxidoreductase activity
URS_1006	COG0688	phosphatidylethanolamine metabolic process
URS_1008	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
URS_1012	COG3830	Belongs to the UPF0237 family
URS_1012	COG0560	Phosphoserine phosphatase
URS_1015	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
URS_1016	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
URS_1017	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
URS_1018	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
URS_1020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
URS_1023	COG3121	Chaperone
URS_1025	COG3188	usher protein
URS_1029	COG2388	GCN5-related N-acetyl-transferase
URS_1030	COG0385	Bile acid
URS_1031	COG1335	isochorismatase
URS_1032	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
URS_1034	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
URS_1036	COG2116	formate transmembrane transporter activity
URS_1037	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
URS_1039	COG2133	pyrroloquinoline quinone binding
URS_1042	COG2983	Belongs to the UPF0260 family
URS_1043	COG5487	UPF0391 membrane protein
URS_1044	COG0412	Dienelactone hydrolase
URS_1046	COG1194	a g-specific adenine glycosylase
URS_1049	COG2818	Glycosylase
URS_1050	COG1064	alcohol dehydrogenase
URS_1051	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
URS_1053	COG0583	DNA-binding transcription factor activity
URS_1054	COG2814	Major facilitator Superfamily
URS_1057	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
URS_1058	COG0484	heat shock protein binding
URS_1061	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
URS_1062	COG1309	transcriptional regulator
URS_1063	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
URS_1064	COG2233	PERMEase
URS_1067	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
URS_1069	COG1252	NADH dehydrogenase
URS_1072	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
URS_1073	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
URS_1074	COG0428	transporter
URS_1076	COG0733	neurotransmitter:sodium symporter activity
URS_1077	COG1012	belongs to the aldehyde dehydrogenase family
URS_1080	COG0693	protein deglycase activity
URS_1086	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
URS_1091	COG0583	DNA-binding transcription factor activity
URS_1092	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
URS_1093	COG0443	Heat shock 70 kDa protein
URS_1096	COG2951	lytic endotransglycosylase activity
URS_1098	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
URS_1102	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
URS_1107	COG0861	Integral membrane protein TerC family
URS_1109	COG0402	S-adenosylhomocysteine deaminase activity
URS_1114	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
URS_1116	COG0706	membrane insertase activity
URS_1117	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
URS_1118	COG0594	ribonuclease P activity
URS_1119	COG0230	Belongs to the bacterial ribosomal protein bL34 family
URS_1120	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
URS_1121	COG0592	DNA-directed DNA polymerase activity
URS_1122	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
URS_1123	COG0187	DNA topoisomerase II activity
URS_1125	COG0488	(ABC) transporter
URS_1129	COG0316	Belongs to the HesB IscA family
URS_1130	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
URS_1131	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
URS_1144	COG2801	Transposase and inactivated derivatives
URS_1148	COG1047	Peptidyl-prolyl cis-trans
URS_1149	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
URS_1150	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
URS_1151	COG0196	riboflavin kinase activity
URS_1154	COG0596	Alpha beta hydrolase
URS_1155	COG1309	transcriptional regulator
URS_1156	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
URS_1157	COG1335	isochorismatase
URS_1158	COG0251	oxidation-reduction process
URS_1159	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
URS_1160	COG2233	PERMEase
URS_1162	COG1116	anion transmembrane transporter activity
URS_1163	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
URS_1164	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
URS_1165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
URS_1166	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
URS_1167	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
URS_1167	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
URS_1171	COG1028	Short-chain dehydrogenase reductase Sdr
URS_1172	COG0546	phosphoglycolate phosphatase activity
URS_1173	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
URS_1179	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
URS_1183	COG3023	N-Acetylmuramoyl-L-alanine amidase
URS_1191	COG1596	polysaccharide export
URS_1192	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
URS_1193	COG1088	dTDP-glucose 4,6-dehydratase activity
URS_1194	COG1091	dTDP-4-dehydrorhamnose reductase activity
URS_1201	COG4641	Protein conserved in bacteria
URS_1201	COG0438	transferase activity, transferring glycosyl groups
URS_1202	COG0438	transferase activity, transferring glycosyl groups
URS_1203	COG0297	glycogen (starch) synthase activity
URS_1206	COG1210	Utp--glucose-1-phosphate uridylyltransferase
URS_1209	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
URS_1212	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
URS_1213	COG0583	DNA-binding transcription factor activity
URS_1214	COG1620	l-lactate permease
URS_1215	COG2186	Transcriptional regulator
URS_1216	COG1304	FMN binding
URS_1217	COG0277	FAD linked oxidase domain protein
URS_1220	COG1522	sequence-specific DNA binding
URS_1221	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
URS_1223	COG0251	oxidation-reduction process
URS_1224	COG1113	amino acid transport
URS_1225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
URS_1229	COG1538	Outer membrane efflux protein
URS_1236	COG1335	isochorismatase
URS_1238	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
URS_1242	COG3706	GGDEF domain
URS_1249	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
URS_1251	COG2814	Major facilitator Superfamily
URS_1256	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
URS_1265	COG4372	Transposase
URS_1268	COG2433	Pfam Transposase IS66
URS_1272	COG3177	Filamentation induced by cAMP protein fic
URS_1289	COG0582	viral genome integration into host DNA
URS_1291	COG3158	transport of potassium into the cell
URS_1298	COG0107	imidazoleglycerol-phosphate synthase activity
URS_1299	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
URS_1304	COG0531	amino acid
URS_1305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
URS_1306	COG1132	(ABC) transporter
URS_1307	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
URS_1309	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
URS_1311	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
URS_1312	COG0131	Imidazoleglycerol-phosphate dehydratase
URS_1318	COG0456	acetyltransferase
URS_1319	COG0427	acetyl-CoA hydrolase
URS_1320	COG2205	protein histidine kinase activity
URS_1321	COG0745	RESPONSE REGULATOR receiver
URS_1325	COG4221	oxidoreductase activity
URS_1327	COG0028	Belongs to the TPP enzyme family
URS_1328	COG0488	(ABC) transporter
URS_1339	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
URS_1342	COG0275	rRNA processing
URS_1345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
URS_1346	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
URS_1347	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
URS_1348	COG2226	methyltransferase
URS_1355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
URS_1356	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
URS_1358	COG0070	glutamate synthase
URS_1358	COG0069	glutamate synthase activity
URS_1358	COG0067	glutamate synthase
URS_1359	COG0493	'glutamate synthase
URS_1360	COG0583	DNA-binding transcription factor activity
URS_1361	COG1960	acyl-CoA dehydrogenase activity
URS_1362	COG1804	L-carnitine dehydratase bile acid-inducible protein F
URS_1363	COG0477	Major facilitator Superfamily
URS_1364	COG1028	Short-chain dehydrogenase reductase Sdr
URS_1366	COG1704	LemA family
URS_1367	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
URS_1380	COG4969	Belongs to the N-Me-Phe pilin family
URS_1381	COG4969	Belongs to the N-Me-Phe pilin family
URS_1382	COG3307	-O-antigen
URS_1384	COG3307	-O-antigen
URS_1385	COG3177	Filamentation induced by cAMP protein fic
URS_1391	COG0322	excinuclease ABC activity
URS_1393	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
URS_1394	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
URS_1394	COG2169	Transcriptional regulator
URS_1396	COG1132	(ABC) transporter
URS_1399	COG1289	transmembrane transporter activity
URS_1402	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
URS_1403	COG1678	Uncharacterized ACR, COG1678
URS_1404	COG0497	DNA recombination
URS_1405	COG3123	guanosine phosphorylase activity
URS_1406	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
URS_1408	COG0237	dephospho-CoA kinase activity
URS_1412	COG0149	triose-phosphate isomerase activity
URS_1417	COG0779	Required for maturation of 30S ribosomal subunits
URS_1418	COG0195	Participates in both transcription termination and antitermination
URS_1422	COG2212	antiporter activity
URS_1424	COG0651	ATP synthesis coupled electron transport
URS_1425	COG1006	Multisubunit Na H antiporter MnhC subunit
URS_1426	COG2111	Na H antiporter
URS_1426	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
URS_1431	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
URS_1438	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
URS_1439	COG1074	ATP-dependent DNA helicase activity
URS_1441	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
URS_1443	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
URS_1444	COG1185	polyribonucleotide nucleotidyltransferase activity
URS_1445	COG2841	Protein conserved in bacteria
URS_1446	COG0598	Magnesium transport protein CorA
URS_1447	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
URS_1450	COG0484	heat shock protein binding
URS_1451	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
URS_1453	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
URS_1457	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
URS_1458	COG0815	Transfers the fatty acyl group on membrane lipoproteins
URS_1459	COG4535	Mg2 and Co2 transporter CorC
URS_1460	COG0425	Belongs to the sulfur carrier protein TusA family
URS_1463	COG0644	oxidoreductase
URS_1463	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
URS_1465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
URS_1467	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
URS_1468	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
URS_1470	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
URS_1472	COG0493	'glutamate synthase
URS_1472	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
URS_1476	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
URS_1478	COG0254	rRNA binding
URS_1479	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
URS_1483	COG0534	Mate efflux family protein
URS_1485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
URS_1487	COG1595	DNA-templated transcription, initiation
URS_1489	COG4221	oxidoreductase activity
URS_1490	COG0583	DNA-binding transcription factor activity
URS_1491	COG0450	alkyl hydroperoxide reductase
URS_1495	COG1530	ribonuclease E activity
URS_1497	COG0564	pseudouridine synthase activity
URS_1500	COG0583	DNA-binding transcription factor activity
URS_1503	COG4993	Dehydrogenase
URS_1504	COG0753	catalase activity
URS_1506	COG1960	acyl-CoA dehydrogenase activity
URS_1508	COG0494	nUDIX hydrolase
URS_1512	COG0583	DNA-binding transcription factor activity
URS_1515	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
URS_1518	COG0473	3-isopropylmalate dehydrogenase activity
URS_1520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
URS_1522	COG1028	Short-chain dehydrogenase reductase Sdr
URS_1523	COG0101	tRNA pseudouridine synthase activity
URS_1530	COG1301	dicarboxylic acid transport
URS_1531	COG0438	transferase activity, transferring glycosyl groups
URS_1532	COG1560	Kdo2-lipid A biosynthetic process
URS_1541	COG2203	Gaf domain
URS_1541	COG3706	GGDEF domain
URS_1541	COG4251	negative regulation of phosphorylation
URS_1541	COG5001	Diguanylate cyclase
URS_1543	COG0210	DNA helicase
URS_1547	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
URS_1547	COG4651	solute:proton antiporter activity
URS_1548	COG0267	Belongs to the bacterial ribosomal protein bL33 family
URS_1551	COG0788	formyltetrahydrofolate deformylase activity
URS_1559	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
URS_1562	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
URS_1569	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
URS_1571	COG2813	Specifically methylates the guanine in position
URS_1571	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
URS_1572	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
URS_1573	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
URS_1574	COG3128	pkhd-type hydroxylase
URS_1575	COG4774	siderophore transport
URS_1576	COG0544	peptidyl-prolyl cis-trans isomerase activity
URS_1577	COG0740	serine-type endopeptidase activity
URS_1582	COG3622	Belongs to the hyi family
URS_1585	COG0784	Response regulator, receiver
URS_1585	COG2205	protein histidine kinase activity
URS_1585	COG5002	protein histidine kinase activity
URS_1589	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
URS_1593	COG2096	Adenosyltransferase
URS_1594	COG4206	TonB-dependent receptor
URS_1596	COG0133	tryptophan synthase activity
URS_1603	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
URS_1604	COG0285	dihydrofolate synthase activity
URS_1608	COG0450	alkyl hydroperoxide reductase
URS_1609	COG0653	protein targeting
URS_1611	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
URS_1612	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
URS_1617	COG2885	chlorophyll binding
URS_1618	COG2199	diguanylate cyclase activity
URS_1625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
URS_1627	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
URS_1627	COG3453	Protein conserved in bacteria
URS_1630	COG1607	acyl-coa hydrolase
URS_1631	COG1956	GAF domain-containing protein
URS_1640	COG0183	Belongs to the thiolase family
URS_1641	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
URS_1641	COG2885	chlorophyll binding
URS_1642	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
URS_1645	COG2832	Protein of unknown function (DUF454)
URS_1646	COG1376	ErfK ybiS ycfS ynhG family protein
URS_1655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
URS_1657	COG1289	transmembrane transporter activity
URS_1658	COG2814	Major facilitator Superfamily
URS_1661	COG0786	glutamate:sodium symporter activity
URS_1662	COG1115	amino acid carrier protein
URS_1663	COG1752	Esterase of the alpha-beta hydrolase superfamily
URS_1666	COG2824	Alkylphosphonate utilization operon protein PhnA
URS_1667	COG0494	nUDIX hydrolase
URS_1668	COG3422	double-strand break repair
URS_1671	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
URS_1673	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
URS_1674	COG3545	Serine hydrolase
URS_1676	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
URS_1676	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
URS_1677	COG0730	response to heat
URS_1679	COG1196	nuclear chromosome segregation
URS_1681	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
URS_1684	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
URS_1688	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
URS_1688	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
URS_1690	COG4106	trans-aconitate 2-methyltransferase activity
URS_1694	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
URS_1695	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
URS_1697	COG0009	L-threonylcarbamoyladenylate synthase
URS_1698	COG3101	peptidyl-lysine hydroxylation
URS_1699	COG1399	metal-binding, possibly nucleic acid-binding protein
URS_1702	COG1028	Short-chain dehydrogenase reductase Sdr
URS_1704	COG1652	LysM domain
URS_1706	COG1733	regulation of RNA biosynthetic process
URS_1707	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
URS_1707	COG0351	phosphomethylpyrimidine kinase
URS_1707	COG0352	thiamine-phosphate diphosphorylase activity
URS_1716	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
URS_1717	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
URS_1719	COG0456	acetyltransferase
URS_1720	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
URS_1721	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
URS_1722	COG0500	methyltransferase
URS_1723	COG0492	ferredoxin-NADP+ reductase activity
URS_1724	COG0531	amino acid
URS_1724	COG1674	ftsk spoiiie
URS_1726	COG1280	lysine exporter protein (LysE YggA)
URS_1728	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
URS_1729	COG2894	cell division
URS_1730	COG0850	regulation of cytokinetic process
URS_1732	COG0204	Acyl-transferase
URS_1733	COG2885	chlorophyll binding
URS_1735	COG0756	dUTP diphosphatase activity
URS_1736	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
URS_1737	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
URS_1739	COG0121	glutamine amidotransferase
URS_1742	COG2914	Belongs to the UPF0125 (RnfH) family
URS_1743	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
URS_1744	COG0735	belongs to the Fur family
URS_1748	COG1968	undecaprenyl-diphosphatase activity
URS_1753	COG0420	3'-5' exonuclease activity
URS_1758	COG2050	protein possibly involved in aromatic compounds catabolism
URS_1759	COG1566	PFAM secretion protein HlyD family protein
URS_1760	COG2814	Major facilitator Superfamily
URS_1761	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
URS_1768	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
URS_1769	COG2223	nitrite transmembrane transporter activity
URS_1771	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
URS_1772	COG1301	dicarboxylic acid transport
URS_1774	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
URS_1775	COG0583	DNA-binding transcription factor activity
URS_1781	COG2223	nitrite transmembrane transporter activity
URS_1784	COG0577	efflux transmembrane transporter activity
URS_1784	COG1136	(ABC) transporter
URS_1785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
URS_1791	COG0028	Belongs to the TPP enzyme family
URS_1793	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
URS_1798	COG2801	Transposase and inactivated derivatives
URS_1830	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
URS_1838	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
URS_1841	COG0084	hydrolase, TatD family'
URS_1843	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
URS_1846	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
URS_1847	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
URS_1852	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
URS_1854	COG2814	Major facilitator Superfamily
URS_1855	COG2814	Major facilitator Superfamily
URS_1857	COG1414	Transcriptional regulator
URS_1861	COG1028	Short-chain dehydrogenase reductase Sdr
URS_1863	COG0446	pyridine nucleotide-disulphide oxidoreductase
URS_1864	COG2271	Major facilitator Superfamily
URS_1867	COG1028	Short-chain dehydrogenase reductase Sdr
URS_1868	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
URS_1869	COG1012	belongs to the aldehyde dehydrogenase family
URS_1870	COG0028	Belongs to the TPP enzyme family
URS_1873	COG1120	ATPase activity
URS_1879	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
URS_1880	COG1012	belongs to the aldehyde dehydrogenase family
URS_1881	COG1309	transcriptional regulator
URS_1882	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
URS_1884	COG1607	acyl-coa hydrolase
URS_1886	COG2009	succinate dehydrogenase
URS_1887	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
URS_1888	COG1053	succinate dehydrogenase
URS_1889	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
URS_1892	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
URS_1893	COG0045	succinate-CoA ligase (ADP-forming) activity
URS_1896	COG1649	PFAM Uncharacterised BCR, COG1649
URS_1896	COG0726	polysaccharide deacetylase
URS_1897	COG1215	transferase activity, transferring glycosyl groups
URS_1900	COG2268	Band 7 protein
URS_1901	COG1585	Membrane protein implicated in regulation of membrane protease activity
URS_1903	COG2354	Protein conserved in bacteria
URS_1904	COG2321	neutral zinc metallopeptidase
URS_1905	COG0531	amino acid
URS_1908	COG0321	lipoyl(octanoyl) transferase activity
URS_1913	COG0500	methyltransferase
URS_1914	COG0586	Pfam SNARE associated Golgi protein
URS_1919	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
URS_1921	COG0193	aminoacyl-tRNA hydrolase activity
URS_1923	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
URS_1931	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
URS_1937	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
URS_1938	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
URS_1939	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
URS_1943	COG1492	cobalamin metabolic process
URS_1944	COG0175	sulfate reduction
URS_1946	COG2851	Citrate transporter
URS_1951	COG0439	Biotin carboxylase
URS_1952	COG0864	Transcriptional regulator
URS_1954	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
URS_1958	COG1116	anion transmembrane transporter activity
URS_1960	COG1253	flavin adenine dinucleotide binding
URS_1964	COG3015	lipoprotein NlpE involved in copper resistance
URS_1966	COG1028	Short-chain dehydrogenase reductase Sdr
URS_1967	COG0829	nickel cation binding
URS_1968	COG0831	urea catabolic process
URS_1969	COG0832	Belongs to the urease beta subunit family
URS_1970	COG0804	urea catabolic process
URS_1971	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
URS_1972	COG0830	nickel cation binding
URS_1973	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
URS_1978	COG0742	ribosomal rna small subunit methyltransferase
URS_1979	COG0768	penicillin binding
URS_1982	COG0563	adenylate kinase activity
URS_1984	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
URS_1985	COG2878	Part of a membrane complex involved in electron transport
URS_1986	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
URS_1988	COG3384	dioxygenase
URS_1991	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
URS_1997	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
URS_1999	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
URS_2002	COG1671	Belongs to the UPF0178 family
URS_2006	COG1136	(ABC) transporter
URS_2008	COG0658	competence protein
URS_2008	COG2333	competence protein COMEC
URS_2012	COG1113	amino acid transport
URS_2013	COG2828	Protein conserved in bacteria
URS_2015	COG0142	geranyltranstransferase activity
URS_2018	COG1752	Esterase of the alpha-beta hydrolase superfamily
URS_2021	COG2814	Major facilitator Superfamily
URS_2022	COG0745	RESPONSE REGULATOR receiver
URS_2025	COG0004	ammonium transporteR
URS_2029	COG0525	valine-tRNA ligase activity
URS_2031	COG1028	Short-chain dehydrogenase reductase Sdr
URS_2032	COG0393	Putative heavy-metal-binding
URS_2033	COG0393	Putative heavy-metal-binding
URS_2034	COG1538	Outer membrane efflux protein
URS_2036	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
URS_2037	COG0671	phosphoesterase, PA-phosphatase related
URS_2040	COG0261	This protein binds to 23S rRNA in the presence of protein L20
URS_2041	COG0211	Belongs to the bacterial ribosomal protein bL27 family
URS_2043	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
URS_2045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
URS_2046	COG1648	precorrin-2 dehydrogenase activity
URS_2046	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
URS_2047	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
URS_2049	COG1733	regulation of RNA biosynthetic process
URS_2060	COG0583	DNA-binding transcription factor activity
URS_2062	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
URS_2063	COG1773	rubredoxin
URS_2065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
URS_2068	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
URS_2072	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
URS_2072	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
URS_2075	COG0523	cobalamin synthesis protein
URS_2077	COG4681	YaeQ
URS_2081	COG0726	polysaccharide deacetylase
URS_2081	COG1649	PFAM Uncharacterised BCR, COG1649
URS_2082	COG1215	transferase activity, transferring glycosyl groups
URS_2088	COG0400	carboxylic ester hydrolase activity
URS_2091	COG0561	phosphatase activity
URS_2092	COG0242	peptide deformylase activity
URS_2093	COG2066	Belongs to the glutaminase family
URS_2095	COG2223	nitrite transmembrane transporter activity
URS_2098	COG3293	Transposase
URS_2100	COG2852	Protein conserved in bacteria
URS_2102	COG0653	protein targeting
URS_2104	COG0306	phosphate transporter
URS_2108	COG1262	PFAM Formylglycine-generating sulfatase enzyme
URS_2112	COG4771	TonB-dependent receptor
URS_2113	COG4771	TonB-dependent receptor
URS_2116	COG0288	reversible hydration of carbon dioxide
URS_2118	COG4181	ATPase activity
URS_2119	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
URS_2121	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
URS_2123	COG0589	response to stress
URS_2125	COG0589	response to stress
URS_2129	COG0505	Belongs to the CarA family
URS_2133	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
URS_2134	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
URS_2135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
URS_2140	COG1929	Belongs to the glycerate kinase type-1 family
URS_2143	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
URS_2148	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
URS_2152	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
URS_2153	COG0459	protein refolding
URS_2154	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
URS_2155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
URS_2156	COG1045	serine acetyltransferase
URS_2159	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
URS_2165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
URS_2166	COG2239	Acts as a magnesium transporter
URS_2168	COG0501	Belongs to the peptidase M48B family
URS_2169	COG1196	nuclear chromosome segregation
URS_2169	COG0741	lytic transglycosylase activity
URS_2169	COG0739	heme binding
URS_2170	COG0037	tRNA processing
URS_2172	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
URS_2173	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
URS_2175	COG0583	DNA-binding transcription factor activity
URS_2178	COG1131	(ABC) transporter
URS_2179	COG0842	Transport permease protein
URS_2180	COG0842	Transport permease protein
URS_2182	COG0583	DNA-binding transcription factor activity
URS_2183	COG0473	3-isopropylmalate dehydrogenase activity
URS_2186	COG4638	Rieske (2fe-2S)
URS_2187	COG1012	belongs to the aldehyde dehydrogenase family
URS_2190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
URS_2190	COG0475	glutathione-regulated potassium exporter activity
URS_2192	COG1203	CRISPR-associated helicase, Cas3
URS_2196	COG2826	transposase and inactivated derivatives, IS30 family
URS_2235	COG3421	Type III restriction
URS_2236	COG2189	Belongs to the N(4) N(6)-methyltransferase family
URS_2249	COG1741	Belongs to the pirin family
URS_2251	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
URS_2252	COG3739	integral membrane protein
URS_2254	COG0586	Pfam SNARE associated Golgi protein
URS_2257	COG1529	Aldehyde oxidase and xanthine dehydrogenase
URS_2258	COG3608	succinylglutamate desuccinylase aspartoacylase
URS_2258	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
URS_2260	COG2826	transposase and inactivated derivatives, IS30 family
URS_2262	COG0134	indole-3-glycerol-phosphate synthase activity
URS_2263	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
URS_2264	COG0512	Glutamine amidotransferase of anthranilate synthase
URS_2265	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
URS_2266	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
URS_2267	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
URS_2268	COG1067	ATP-dependent peptidase activity
URS_2271	COG0254	rRNA binding
URS_2272	COG0583	DNA-binding transcription factor activity
URS_2273	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
URS_2274	COG4208	sulfate ABC transporter
URS_2275	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
URS_2277	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
URS_2278	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
URS_2279	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
URS_2280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
URS_2282	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
URS_2283	COG0174	glutamine synthetase
URS_2285	COG0481	GTPase activity
URS_2286	COG0681	Belongs to the peptidase S26 family
URS_2288	COG0571	ribonuclease III activity
URS_2289	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
URS_2291	COG1381	Involved in DNA repair and RecF pathway recombination
URS_2292	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
URS_2295	COG3161	chorismate lyase activity
URS_2296	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
URS_2298	COG1301	dicarboxylic acid transport
URS_2302	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
URS_2303	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
URS_2308	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
URS_2310	COG3384	dioxygenase
URS_2311	COG1335	isochorismatase
URS_2314	COG1720	tRNA m6t6A37 methyltransferase activity
URS_2315	COG3706	GGDEF domain
URS_2316	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
URS_2317	COG3111	PFAM Bacterial OB fold (BOF) protein
URS_2318	COG0745	RESPONSE REGULATOR receiver
URS_2319	COG0642	Histidine kinase
URS_2321	COG0494	nUDIX hydrolase
URS_2323	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
URS_2324	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
URS_2325	COG3139	Protein of unknown function (DUF1315)
URS_2326	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
URS_2327	COG1301	dicarboxylic acid transport
URS_2329	COG0659	secondary active sulfate transmembrane transporter activity
URS_2331	COG2252	PERMEase
URS_2332	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
URS_2335	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
URS_2338	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
URS_2341	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
URS_2342	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
URS_2345	COG0667	Aldo Keto reductase
URS_2347	COG1765	OsmC-like protein
URS_2353	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
URS_2353	COG0116	Belongs to the methyltransferase superfamily
URS_2354	COG0540	Belongs to the ATCase OTCase family
URS_2360	COG2995	paraquat-inducible protein a
URS_2361	COG3008	intermembrane lipid transfer
URS_2361	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
URS_2363	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
URS_2363	COG0047	phosphoribosylformylglycinamidine synthase activity
URS_2368	COG1024	Enoyl-CoA hydratase
URS_2369	COG1056	cytidyltransferase-related domain
URS_2369	COG1051	belongs to the nudix hydrolase family
URS_2370	COG2353	YceI-like domain
URS_2371	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
URS_2373	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
URS_2374	COG0602	queuosine metabolic process
URS_2376	COG4625	pathogenesis
URS_2379	COG1509	lysine 2,3-aminomutase activity
URS_2380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
URS_2382	COG1966	Carbon starvation protein
URS_2383	COG2879	small protein
URS_2384	COG0714	Associated with various cellular activities
URS_2386	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
URS_2388	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
URS_2390	COG0596	Alpha beta hydrolase
URS_2391	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
URS_2396	COG3706	GGDEF domain
URS_2404	COG0436	Aminotransferase
URS_2405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
URS_2406	COG0386	Belongs to the glutathione peroxidase family
URS_2412	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
URS_2413	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
URS_2419	COG0012	GTP binding
URS_2420	COG2011	ABC-type metal ion transport system permease component
URS_2421	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
URS_2422	COG1464	Belongs to the NlpA lipoprotein family
URS_2428	COG2826	transposase and inactivated derivatives, IS30 family
URS_2429	COG1012	belongs to the aldehyde dehydrogenase family
URS_2430	COG0471	metal ion transport
URS_2431	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
URS_2432	COG2814	Major facilitator Superfamily
URS_2435	COG0583	DNA-binding transcription factor activity
URS_2437	COG2707	UPF0756 membrane protein
URS_2439	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
URS_2444	COG2826	transposase and inactivated derivatives, IS30 family
URS_2448	COG0564	pseudouridine synthase activity
URS_2449	COG0802	atpase or kinase
URS_2450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
URS_2451	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
URS_2452	COG1923	regulation of RNA biosynthetic process
URS_2453	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
URS_2454	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
URS_2456	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
URS_2457	COG0357	Ribosomal RNA small subunit methyltransferase G
URS_2458	COG1192	Involved in chromosome partitioning
URS_2459	COG1475	DNA binding
URS_2460	COG0811	peptide transport
URS_2462	COG1132	(ABC) transporter
URS_2463	COG1663	tetraacyldisaccharide 4'-kinase activity
URS_2467	COG0084	hydrolase, TatD family'
URS_2476	COG0590	tRNA wobble adenosine to inosine editing
URS_2478	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
URS_2480	COG0776	regulation of translation
URS_2483	COG0284	orotidine-5'-phosphate decarboxylase activity
URS_2487	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
URS_2491	COG1253	flavin adenine dinucleotide binding
URS_2494	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
URS_2496	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
URS_2497	COG0730	response to heat
URS_2501	COG4773	Receptor
URS_2502	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
URS_2509	COG2815	serine threonine protein kinase
URS_2509	COG0515	serine threonine protein kinase
URS_2517	COG2011	ABC-type metal ion transport system permease component
URS_2518	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
URS_2519	COG1464	Belongs to the NlpA lipoprotein family
URS_2521	COG0138	bifunctional purine biosynthesis protein purh
URS_2522	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
URS_2527	COG0445	tRNA wobble uridine modification
URS_2530	COG2308	Evidence 4 Homologs of previously reported genes of
URS_2532	COG1305	Transglutaminase-like
URS_2535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
URS_2536	COG0305	Participates in initiation and elongation during chromosome replication
URS_2538	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
URS_2538	COG0517	IMP dehydrogenase activity
URS_2544	COG0552	protein localization to endoplasmic reticulum
URS_2549	COG1294	oxidase, subunit
URS_2551	COG1585	Membrane protein implicated in regulation of membrane protease activity
URS_2553	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
URS_2556	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
URS_2557	COG0569	domain protein
URS_2558	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
URS_2559	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
URS_2562	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
URS_2564	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
URS_2565	COG0542	response to heat
URS_2570	COG0765	amino acid transport
URS_2571	COG0765	amino acid transport
URS_2572	COG1126	abc transporter atp-binding protein
URS_2575	COG0217	transcriptional regulatory protein
URS_2578	COG4774	siderophore transport
URS_2579	COG2193	ferroxidase activity
URS_2598	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
URS_2600	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
URS_2600	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
URS_2606	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
URS_2607	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
URS_2610	COG2353	YceI-like domain
URS_2612	COG0505	Belongs to the CarA family
URS_2616	COG1454	alcohol dehydrogenase
URS_2617	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
URS_2619	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
URS_2620	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
URS_2623	COG0308	aminopeptidase N
URS_2625	COG0589	response to stress
URS_2628	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
URS_2630	COG3135	benzoate transporter
URS_2638	COG1028	Short-chain dehydrogenase reductase Sdr
URS_2645	COG0824	Thioesterase
URS_2646	COG1454	alcohol dehydrogenase
URS_2647	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
URS_2648	COG0812	UDP-N-acetylmuramate dehydrogenase activity
URS_2652	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
URS_2653	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
URS_2659	COG0316	Belongs to the HesB IscA family
URS_2660	COG0822	iron-sulfur transferase activity
URS_2666	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
URS_2667	COG2814	Major facilitator Superfamily
URS_2679	COG0024	Methionine aminopeptidase
URS_2680	COG0583	DNA-binding transcription factor activity
URS_2681	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
URS_2683	COG0583	DNA-binding transcription factor activity
URS_2684	COG1960	acyl-CoA dehydrogenase activity
URS_2686	COG2814	Major facilitator Superfamily
URS_2687	COG1804	L-carnitine dehydratase bile acid-inducible protein F
URS_2695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
URS_2697	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
URS_2699	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
URS_2702	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
URS_2705	COG1346	cytolysis
URS_2707	COG0583	DNA-binding transcription factor activity
URS_2715	COG0644	oxidoreductase
URS_2715	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
URS_2716	COG2814	Major facilitator Superfamily
URS_2719	COG2814	Major facilitator Superfamily
URS_2722	COG2814	Major facilitator Superfamily
URS_2725	COG0183	Belongs to the thiolase family
URS_2726	COG1250	3-hydroxyacyl-CoA dehydrogenase
URS_2727	COG1028	Short-chain dehydrogenase reductase Sdr
URS_2728	COG1024	Enoyl-CoA hydratase
URS_2729	COG1960	acyl-CoA dehydrogenase activity
URS_2730	COG2814	Major facilitator Superfamily
URS_2731	COG2814	Major facilitator Superfamily
URS_2732	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
URS_2733	COG3328	transposase activity
URS_2735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
URS_2737	COG2814	Major facilitator Superfamily
URS_2739	COG1960	acyl-CoA dehydrogenase activity
URS_2740	COG1024	Enoyl-CoA hydratase
URS_2741	COG0235	Class ii aldolase
URS_2742	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
URS_2743	COG0583	DNA-binding transcription factor activity
URS_2746	COG1414	Transcriptional regulator
URS_2747	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
URS_2748	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
URS_2749	COG0183	Belongs to the thiolase family
URS_2750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
URS_2751	COG0596	Alpha beta hydrolase
URS_2752	COG2271	Major facilitator Superfamily
URS_2753	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
URS_2754	COG3485	protocatechuate 3,4-dioxygenase
URS_2755	COG3485	protocatechuate 3,4-dioxygenase
URS_2756	COG0710	3-dehydroquinate dehydratase activity
URS_2757	COG3420	alginic acid biosynthetic process
URS_2758	COG3659	wide pore channel activity
URS_2771	COG1846	Transcriptional regulator
URS_2772	COG0583	DNA-binding transcription factor activity
URS_2773	COG1027	Aspartate ammonia-lyase
URS_2782	COG0640	Transcriptional regulator
URS_2785	COG3122	Protein conserved in bacteria
URS_2786	COG0668	transmembrane transport
URS_2787	COG1132	(ABC) transporter
URS_2790	COG0509	glycine decarboxylation via glycine cleavage system
URS_2791	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
URS_2794	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
URS_2796	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
URS_2806	COG1960	acyl-CoA dehydrogenase activity
URS_2808	COG2826	transposase and inactivated derivatives, IS30 family
URS_2809	COG2194	sulfuric ester hydrolase activity
URS_2814	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
URS_2815	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
URS_2819	COG0697	spore germination
URS_2820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
URS_2822	COG0725	ABC transporter, periplasmic molybdate-binding protein
URS_2823	COG0303	'Molybdopterin
URS_2824	COG0315	cyclic pyranopterin monophosphate synthase activity
URS_2824	COG0521	Mo-molybdopterin cofactor biosynthetic process
URS_2829	COG0243	molybdopterin cofactor binding
URS_2830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
URS_2831	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
URS_2831	COG2146	nitrite reductase [NAD(P)H] activity
URS_2832	COG2223	nitrite transmembrane transporter activity
URS_2833	COG0745	RESPONSE REGULATOR receiver
URS_2834	COG1116	anion transmembrane transporter activity
URS_2834	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
URS_2836	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
URS_2837	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
URS_2839	COG0148	phosphopyruvate hydratase activity
URS_2841	COG0504	CTP synthase activity
URS_2845	COG1902	pentaerythritol trinitrate reductase activity
URS_2845	COG0446	pyridine nucleotide-disulphide oxidoreductase
URS_2847	COG2267	carboxylic ester hydrolase activity
URS_2848	COG0477	Major facilitator Superfamily
URS_2849	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
URS_2850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
URS_2852	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
URS_2852	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
URS_2852	COG0506	proline dehydrogenase activity
URS_2853	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
URS_2854	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
URS_2856	COG3698	Phosphodiester glycosidase
URS_2865	COG0697	spore germination
URS_2866	COG0191	fructose-bisphosphate aldolase activity
URS_2868	COG0126	phosphoglycerate kinase activity
URS_2870	COG0424	maF-like protein
URS_2872	COG2850	peptidyl-arginine hydroxylation
URS_2873	COG0069	glutamate synthase activity
URS_2876	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
URS_2877	COG0702	epimerase
URS_2878	COG0268	Binds directly to 16S ribosomal RNA
URS_2879	COG3594	Acyltransferase
URS_2881	COG1218	3'(2'),5'-bisphosphate nucleotidase
URS_2882	COG1011	Hydrolase
URS_2883	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
URS_2884	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
URS_2885	COG2137	regulation of response to DNA damage stimulus
URS_2887	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
URS_2889	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
URS_2894	COG0575	Belongs to the CDS family
URS_2895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
URS_2896	COG0233	cytoplasmic translational termination
URS_2897	COG0528	UMP kinase activity
URS_2899	COG3852	Histidine kinase
URS_2900	COG2204	response regulator
URS_2902	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
URS_2906	COG2963	transposase activity
URS_2908	COG3328	transposase activity
URS_2909	COG2801	Transposase and inactivated derivatives
URS_2916	COG0729	surface antigen
URS_2918	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
URS_2920	COG0745	RESPONSE REGULATOR receiver
URS_2921	COG2205	protein histidine kinase activity
URS_2923	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
URS_2924	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
URS_2926	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
URS_2932	COG1960	acyl-CoA dehydrogenase activity
URS_2933	COG1960	acyl-CoA dehydrogenase activity
URS_2935	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
URS_2936	COG2207	Transcriptional regulator
URS_2941	COG1968	undecaprenyl-diphosphatase activity
URS_2942	COG3042	response to heat
URS_2950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
URS_2951	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
URS_2955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
URS_2956	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
URS_2957	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
URS_2958	COG2890	protein-(glutamine-N5) methyltransferase activity
URS_2959	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
URS_2961	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
URS_2962	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
URS_2965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
URS_2966	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
URS_2967	COG1845	cytochrome c oxidase, subunit III
URS_2968	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
URS_2970	COG0360	Binds together with S18 to 16S ribosomal RNA
URS_2971	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
URS_2974	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
URS_2976	COG3100	YcgL domain-containing protein
URS_2978	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
URS_2984	COG0537	adenosine 5'-monophosphoramidase activity
URS_2987	COG0828	Belongs to the bacterial ribosomal protein bS21 family
URS_2988	COG1610	YqeY-like protein
URS_2990	COG4783	chaperone-mediated protein folding
URS_2996	COG0167	dihydroorotate dehydrogenase activity
URS_3000	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
URS_3002	COG0778	Nitroreductase
URS_3004	COG0513	Belongs to the DEAD box helicase family
URS_3012	COG0625	glutathione transferase activity
URS_3017	COG0220	tRNA (guanine-N7-)-methyltransferase activity
URS_3018	COG1960	acyl-CoA dehydrogenase activity
URS_3020	COG3706	GGDEF domain
URS_3022	COG4716	Myosin-crossreactive antigen
URS_3026	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
URS_3027	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
URS_3028	COG1385	rRNA (uridine-N3-)-methyltransferase activity
URS_3032	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
URS_3033	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
URS_3034	COG0583	DNA-binding transcription factor activity
URS_3036	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
URS_3039	COG1686	Belongs to the peptidase S11 family
URS_3040	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
URS_3042	COG0482	sulfurtransferase activity
URS_3043	COG2915	High frequency lysogenization protein hflD homolog
URS_3046	COG0616	signal peptide processing
URS_3047	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
URS_3049	COG0573	inorganic phosphate transmembrane transporter activity
URS_3050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
URS_3051	COG0076	glutamate decarboxylase activity
URS_3052	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
URS_3056	COG1309	transcriptional regulator
URS_3057	COG0783	Belongs to the Dps family
URS_3059	COG0564	pseudouridine synthase activity
URS_3060	COG3193	protein, possibly involved in utilization of glycolate and propanediol
URS_3062	COG0352	thiamine-phosphate diphosphorylase activity
URS_3064	COG1686	Belongs to the peptidase S11 family
URS_3066	COG0589	response to stress
URS_3069	COG0671	phosphoesterase, PA-phosphatase related
URS_3072	COG0745	RESPONSE REGULATOR receiver
URS_3073	COG0642	Histidine kinase
URS_3075	COG2801	Transposase and inactivated derivatives
URS_3076	COG3328	transposase activity
URS_3085	COG3177	Filamentation induced by cAMP protein fic
URS_3087	COG1401	restriction endodeoxyribonuclease activity
URS_3089	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
URS_3089	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
URS_3091	COG3586	endonuclease activity
URS_3112	COG0582	viral genome integration into host DNA
URS_3114	COG1131	(ABC) transporter
URS_3115	COG0842	Transport permease protein
URS_3116	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
URS_3116	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
URS_3118	COG0772	Belongs to the SEDS family
URS_3119	COG2951	lytic endotransglycosylase activity
URS_3126	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
URS_3127	COG0052	Belongs to the universal ribosomal protein uS2 family
URS_3128	COG0024	Methionine aminopeptidase
URS_3132	COG2175	clavaminate synthase activity
URS_3134	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
URS_3137	COG4372	Transposase
URS_3145	COG4968	Prepilin-type N-terminal cleavage methylation domain
URS_3147	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
URS_3149	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
URS_3157	COG1538	Outer membrane efflux protein
URS_3162	COG1137	ATPase activity
URS_3163	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
URS_3165	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
URS_3169	COG4993	Dehydrogenase
URS_3170	COG2175	clavaminate synthase activity
URS_3171	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
URS_3172	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
URS_3173	COG4521	taurine ABC transporter
URS_3176	COG2255	four-way junction helicase activity
URS_3177	COG0824	Thioesterase
URS_3181	COG0823	Involved in the tonB-independent uptake of proteins
URS_3185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
URS_3189	COG5001	Diguanylate cyclase
URS_3189	COG4251	negative regulation of phosphorylation
URS_3189	COG3706	GGDEF domain
URS_3189	COG2203	Gaf domain
URS_3190	COG0418	dihydroorotase activity
URS_3191	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
URS_3193	COG0833	amino acid
URS_3195	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
URS_3196	COG0243	molybdopterin cofactor binding
URS_3198	COG1643	Atp-dependent helicase
URS_3199	COG0450	alkyl hydroperoxide reductase
URS_3207	COG3022	response to hydroperoxide
URS_3208	COG2195	Cleaves the N-terminal amino acid of tripeptides
URS_3210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
URS_3214	COG1960	acyl-CoA dehydrogenase activity
URS_3218	COG2015	COG2015, Alkyl sulfatase and related hydrolases
URS_3222	COG2985	domain, Protein
URS_3223	COG1764	response to oxidative stress
URS_3228	COG0632	four-way junction helicase activity
URS_3229	COG4302	ethanolamine ammonia-lyase activity
URS_3230	COG4303	Ethanolamine ammonia lyase large subunit
URS_3231	COG0531	amino acid
URS_3233	COG2070	2-Nitropropane dioxygenase
URS_3235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
URS_3238	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
URS_3243	COG2962	Rard protein
URS_3244	COG3040	lipid binding
URS_3245	COG0556	nucleotide-excision repair
URS_3247	COG0745	RESPONSE REGULATOR receiver
URS_3247	COG3706	GGDEF domain
URS_3248	COG0257	Belongs to the bacterial ribosomal protein bL36 family
URS_3262	COG1802	Transcriptional regulator
URS_3266	COG1522	sequence-specific DNA binding
URS_3277	COG0612	Peptidase, M16
URS_3278	COG0038	chloride channel
URS_3279	COG0384	phenazine biosynthesis protein PhzF
URS_3282	COG1187	pseudouridine synthase activity
URS_3285	COG2351	hydroxyisourate hydrolase activity
URS_3289	COG4172	Belongs to the ABC transporter superfamily
URS_3290	COG4239	(ABC) transporter, permease
URS_3291	COG4174	ABC transporter (Permease)
URS_3292	COG4166	transmembrane transport
URS_3293	COG1388	LysM domain
URS_3293	COG0741	lytic transglycosylase activity
URS_3293	COG1388	LysM domain
URS_3293	COG0741	lytic transglycosylase activity
URS_3294	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
URS_3299	COG0792	nuclease activity
URS_3300	COG3107	peptidoglycan biosynthetic process
URS_3303	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
URS_3304	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
URS_3305	COG0006	proline dipeptidase activity
URS_3306	COG3079	Belongs to the UPF0149 family
URS_3330	COG0640	Transcriptional regulator
URS_3332	COG0798	PFAM Bile acid sodium symporter
URS_3333	COG0431	NADPH-dependent FMN reductase
URS_3334	COG0492	ferredoxin-NADP+ reductase activity
URS_3336	COG3316	Transposase and inactivated derivatives
URS_3337	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
URS_3338	COG0583	DNA-binding transcription factor activity
URS_3340	COG2233	PERMEase
URS_3344	COG0583	DNA-binding transcription factor activity
URS_3353	COG3316	Transposase and inactivated derivatives
URS_3361	COG2205	protein histidine kinase activity
URS_3364	COG2132	Multicopper oxidase
URS_3372	COG3264	Mechanosensitive ion channel
URS_3372	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
URS_3376	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
URS_3377	COG0501	Belongs to the peptidase M48B family
URS_3385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
URS_3386	COG0542	response to heat
URS_3390	COG2072	flavoprotein involved in K transport
URS_3392	COG2144	transferase activity, transferring acyl groups
URS_3397	COG3604	Transcriptional regulator
URS_3405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
URS_3407	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
URS_3408	COG1113	amino acid transport
URS_3409	COG0697	spore germination
URS_3410	COG0582	viral genome integration into host DNA
URS_3411	COG2369	cell adhesion
URS_3415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
URS_3416	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
URS_3418	COG3328	transposase activity
URS_3421	COG3328	transposase activity
URS_3432	COG1785	Belongs to the alkaline phosphatase family
URS_3439	COG1192	Involved in chromosome partitioning
URS_3442	COG1595	DNA-templated transcription, initiation
URS_3444	COG3220	belongs to the UPF0276 family
URS_3454	COG3316	Transposase and inactivated derivatives
URS_3455	COG2963	transposase activity
URS_3456	COG1979	alcohol dehydrogenase
URS_3459	COG1012	belongs to the aldehyde dehydrogenase family
URS_3460	COG1902	pentaerythritol trinitrate reductase activity
URS_3462	COG1309	transcriptional regulator
URS_3463	COG2130	NADP-dependent
URS_3465	COG1764	response to oxidative stress
URS_3466	COG1846	Transcriptional regulator