locus-tag	class	description
LSO59_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LSO59_00010	COG0592	DNA-directed DNA polymerase activity
LSO59_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LSO59_00020	COG0187	DNA topoisomerase II activity
LSO59_00030	COG0488	(ABC) transporter
LSO59_00050	COG0316	Belongs to the HesB IscA family
LSO59_00055	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LSO59_00060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LSO59_00095	COG0693	protein deglycase activity
LSO59_00110	COG1012	belongs to the aldehyde dehydrogenase family
LSO59_00115	COG0733	neurotransmitter:sodium symporter activity
LSO59_00125	COG0428	transporter
LSO59_00130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LSO59_00135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LSO59_00150	COG1252	NADH dehydrogenase
LSO59_00155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LSO59_00170	COG2233	PERMEase
LSO59_00175	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LSO59_00180	COG1309	transcriptional regulator
LSO59_00185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LSO59_00200	COG0484	heat shock protein binding
LSO59_00205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LSO59_00215	COG2814	Major facilitator Superfamily
LSO59_00220	COG0583	DNA-binding transcription factor activity
LSO59_00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSO59_00235	COG1064	alcohol dehydrogenase
LSO59_00240	COG2818	Glycosylase
LSO59_00255	COG1194	a g-specific adenine glycosylase
LSO59_00265	COG0412	Dienelactone hydrolase
LSO59_00270	COG5487	UPF0391 membrane protein
LSO59_00275	COG2983	Belongs to the UPF0260 family
LSO59_00290	COG2133	pyrroloquinoline quinone binding
LSO59_00300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LSO59_00305	COG2116	formate transmembrane transporter activity
LSO59_00310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LSO59_00320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LSO59_00325	COG1335	isochorismatase
LSO59_00330	COG0385	Bile acid
LSO59_00335	COG2388	GCN5-related N-acetyl-transferase
LSO59_00355	COG3188	usher protein
LSO59_00365	COG3121	Chaperone
LSO59_00380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LSO59_00390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LSO59_00395	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LSO59_00400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LSO59_00405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LSO59_00420	COG0560	Phosphoserine phosphatase
LSO59_00420	COG3830	Belongs to the UPF0237 family
LSO59_00440	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LSO59_00450	COG0688	phosphatidylethanolamine metabolic process
LSO59_00460	COG0300	oxidoreductase activity
LSO59_00495	COG0436	Aminotransferase
LSO59_00500	COG2733	membrane
LSO59_00515	COG2918	glutathione biosynthetic process
LSO59_00520	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LSO59_00530	COG3150	esterase
LSO59_00595	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
LSO59_00600	COG4266	Belongs to the allantoicase family
LSO59_00605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LSO59_00615	COG1247	-acetyltransferase
LSO59_00660	COG0625	glutathione transferase activity
LSO59_00665	COG3706	GGDEF domain
LSO59_00680	COG1393	Belongs to the ArsC family
LSO59_00685	COG0708	Exodeoxyribonuclease III
LSO59_00710	COG0189	ligase activity
LSO59_00715	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LSO59_00725	COG1181	Belongs to the D-alanine--D-alanine ligase family
LSO59_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LSO59_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LSO59_00775	COG2119	membrane
LSO59_00780	COG0426	domain, Protein
LSO59_00780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LSO59_00800	COG0259	pyridoxamine-phosphate oxidase activity
LSO59_00805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LSO59_00810	COG1476	TRANSCRIPTIONal
LSO59_00835	COG1902	pentaerythritol trinitrate reductase activity
LSO59_00845	COG1519	Transferase
LSO59_00855	COG0668	transmembrane transport
LSO59_00865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LSO59_00895	COG0004	ammonium transporteR
LSO59_00910	COG0784	Response regulator, receiver
LSO59_00910	COG2205	protein histidine kinase activity
LSO59_00915	COG3162	membrane
LSO59_00920	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LSO59_01050	COG1733	regulation of RNA biosynthetic process
LSO59_01055	COG2249	NAD(P)H dehydrogenase (quinone) activity
LSO59_01090	COG1192	Involved in chromosome partitioning
LSO59_01105	COG0586	Pfam SNARE associated Golgi protein
LSO59_01110	COG2259	Doxx family
LSO59_01115	COG3111	PFAM Bacterial OB fold (BOF) protein
LSO59_01120	COG0519	Catalyzes the synthesis of GMP from XMP
LSO59_01120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LSO59_01170	COG0018	arginyl-trna synthetase
LSO59_01180	COG0281	malic enzyme
LSO59_01195	COG1280	lysine exporter protein (LysE YggA)
LSO59_01200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LSO59_01205	COG1121	(ABC) transporter
LSO59_01255	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LSO59_01260	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LSO59_01290	COG0386	Belongs to the glutathione peroxidase family
LSO59_01300	COG2814	Major facilitator Superfamily
LSO59_01305	COG1309	transcriptional regulator
LSO59_01310	COG0697	spore germination
LSO59_01350	COG3845	ABC transporter
LSO59_01355	COG4603	Belongs to the binding-protein-dependent transport system permease family
LSO59_01360	COG1079	Belongs to the binding-protein-dependent transport system permease family
LSO59_01365	COG0009	L-threonylcarbamoyladenylate synthase
LSO59_01370	COG0758	DNA mediated transformation
LSO59_01375	COG1652	LysM domain
LSO59_01405	COG1309	transcriptional regulator
LSO59_01455	COG0477	Major facilitator Superfamily
LSO59_01460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LSO59_01480	COG1253	flavin adenine dinucleotide binding
LSO59_01490	COG2860	membrane
LSO59_01500	COG0477	Major facilitator Superfamily
LSO59_01510	COG0318	PFAM AMP-dependent synthetase and ligase
LSO59_01525	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LSO59_01540	COG0606	chelatase, subunit chli
LSO59_01550	COG0347	Belongs to the P(II) protein family
LSO59_01555	COG0004	ammonium transporteR
LSO59_01565	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LSO59_01565	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LSO59_01600	COG0795	lipopolysaccharide-transporting ATPase activity
LSO59_01605	COG0795	lipopolysaccharide-transporting ATPase activity
LSO59_01610	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LSO59_01615	COG0793	Belongs to the peptidase S41A family
LSO59_01630	COG2197	response regulator
LSO59_01640	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LSO59_01650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LSO59_01655	COG4974	Belongs to the 'phage' integrase family
LSO59_01675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LSO59_01680	COG0772	Belongs to the SEDS family
LSO59_01685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LSO59_01690	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LSO59_01695	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LSO59_01700	COG0494	nUDIX hydrolase
LSO59_01730	COG3275	phosphorelay sensor kinase activity
LSO59_01740	COG0181	hydroxymethylbilane synthase activity
LSO59_01790	COG1716	ATPase activity
LSO59_01825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LSO59_01845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LSO59_01850	COG0081	regulation of translation
LSO59_01865	COG0085	RNA polymerase activity
LSO59_01870	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LSO59_01905	COG0326	Molecular chaperone. Has ATPase activity
LSO59_01940	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LSO59_01965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LSO59_01970	COG1758	RNA polymerase activity
LSO59_01975	COG0194	GDP metabolic process
LSO59_02020	COG0228	four-way junction DNA binding
LSO59_02025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LSO59_02035	COG0335	large ribosomal subunit rRNA binding
LSO59_02040	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LSO59_02045	COG5380	lipid catabolic process
LSO59_02050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LSO59_02070	COG5006	permease, DMT superfamily
LSO59_02075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LSO59_02080	COG0277	FAD linked oxidase domain protein
LSO59_02105	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LSO59_02110	COG2249	NAD(P)H dehydrogenase (quinone) activity
LSO59_02120	COG2814	Major facilitator Superfamily
LSO59_02135	COG0628	permease
LSO59_02140	COG1192	Involved in chromosome partitioning
LSO59_02185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LSO59_02200	COG0583	DNA-binding transcription factor activity
LSO59_02220	COG0752	glycyl-tRNA synthetase alpha subunit
LSO59_02235	COG0517	IMP dehydrogenase activity
LSO59_02240	COG1983	PspC domain protein
LSO59_02250	COG1960	acyl-CoA dehydrogenase activity
LSO59_02265	COG2885	chlorophyll binding
LSO59_02275	COG0408	coproporphyrinogen oxidase activity
LSO59_02280	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LSO59_02285	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LSO59_02305	COG0513	Belongs to the DEAD box helicase family
LSO59_02315	COG1127	ABC transporter
LSO59_02320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LSO59_02340	COG0598	Magnesium transport protein CorA
LSO59_02350	COG0494	nUDIX hydrolase
LSO59_02355	COG1040	competence protein
LSO59_02360	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LSO59_02375	COG2937	Belongs to the GPAT DAPAT family
LSO59_02380	COG1946	Acyl-CoA thioesterase
LSO59_02385	COG1301	dicarboxylic acid transport
LSO59_02400	COG1959	2 iron, 2 sulfur cluster binding
LSO59_02405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LSO59_02405	COG1017	nitric oxide dioxygenase activity
LSO59_02410	COG0433	COG0433 Predicted ATPase
LSO59_02425	COG0051	transcription antitermination factor activity, RNA binding
LSO59_02430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LSO59_02435	COG0088	Forms part of the polypeptide exit tunnel
LSO59_02450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LSO59_02455	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LSO59_02465	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LSO59_02475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LSO59_02480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LSO59_02485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LSO59_02490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LSO59_02500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LSO59_02505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LSO59_02515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LSO59_02540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LSO59_02550	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LSO59_02555	COG0202	RNA polymerase activity
LSO59_02560	COG0203	ribosomal protein L17
LSO59_02565	COG2072	flavoprotein involved in K transport
LSO59_02570	COG1960	acyl-CoA dehydrogenase activity
LSO59_02575	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LSO59_02605	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LSO59_02610	COG0339	signal peptide processing
LSO59_02620	COG0557	exoribonuclease II activity
LSO59_02665	COG0179	Fumarylacetoacetate (FAA) hydrolase
LSO59_02675	COG2814	Major facilitator Superfamily
LSO59_02680	COG0583	DNA-binding transcription factor activity
LSO59_02695	COG1295	ribonuclease BN
LSO59_02730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LSO59_02735	COG1702	phosphate starvation-inducible protein PhoH
LSO59_02740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LSO59_02745	COG0739	heme binding
LSO59_02745	COG0741	lytic transglycosylase activity
LSO59_02745	COG1196	nuclear chromosome segregation
LSO59_02755	COG0039	L-malate dehydrogenase activity
LSO59_02775	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LSO59_02780	COG1183	phosphatidylcholine synthase activity
LSO59_02840	COG2969	positive regulation of protein catabolic process
LSO59_02845	COG0625	glutathione transferase activity
LSO59_02850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LSO59_02860	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LSO59_02865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LSO59_02870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LSO59_02890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LSO59_02905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LSO59_02910	COG1408	metallophosphoesterase
LSO59_02915	COG0477	Major facilitator Superfamily
LSO59_02920	COG1272	protein, Hemolysin III
LSO59_02930	COG2153	protein acetylation
LSO59_02940	COG4667	esterase of the alpha-beta hydrolase superfamily
LSO59_02955	COG0183	Belongs to the thiolase family
LSO59_02970	COG2207	Transcriptional regulator
LSO59_02990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LSO59_03000	COG0442	prolyl-tRNA aminoacylation
LSO59_03035	COG0840	transmembrane signaling receptor activity
LSO59_03040	COG0643	Histidine kinase
LSO59_03040	COG2198	Histidine kinase
LSO59_03055	COG1690	Belongs to the RtcB family
LSO59_03060	COG0833	amino acid
LSO59_03065	COG2813	Specifically methylates the guanine in position
LSO59_03070	COG2233	PERMEase
LSO59_03075	COG1217	gtp-binding protein TYPA
LSO59_03090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LSO59_03095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LSO59_03100	COG2094	Belongs to the DNA glycosylase MPG family
LSO59_03105	COG4772	TonB-dependent receptor
LSO59_03110	COG1902	pentaerythritol trinitrate reductase activity
LSO59_03145	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
LSO59_03200	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LSO59_03205	COG0154	amidase activity
LSO59_03210	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LSO59_03215	COG1077	Cell shape determining protein MreB Mrl
LSO59_03220	COG1792	Involved in formation and maintenance of cell shape
LSO59_03230	COG0424	maF-like protein
LSO59_03235	COG1530	ribonuclease E activity
LSO59_03245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LSO59_03255	COG0560	Phosphoserine phosphatase
LSO59_03270	COG2350	Protein conserved in bacteria
LSO59_03285	COG0583	DNA-binding transcription factor activity
LSO59_03290	COG0667	Aldo Keto reductase
LSO59_03295	COG3781	membrane
LSO59_03300	COG2003	Belongs to the UPF0758 family
LSO59_03305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LSO59_03310	COG3783	Cytochrome b(562)
LSO59_03320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LSO59_03330	COG1162	GTPase activity
LSO59_03335	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LSO59_03345	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LSO59_03345	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LSO59_03355	COG1335	isochorismatase
LSO59_03360	COG0857	belongs to the CobB CobQ family
LSO59_03360	COG0280	phosphate acetyltransferase
LSO59_03365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LSO59_03370	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LSO59_03375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LSO59_03390	COG0793	Belongs to the peptidase S41A family
LSO59_03410	COG0105	UTP biosynthetic process
LSO59_03435	COG0124	histidyl-tRNA synthetase
LSO59_03470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LSO59_03480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LSO59_03495	COG2986	histidine ammonia-lyase
LSO59_03515	COG0644	oxidoreductase
LSO59_03535	COG1028	Short-chain dehydrogenase reductase Sdr
LSO59_03540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LSO59_03570	COG1862	Preprotein translocase
LSO59_03580	COG1704	LemA family
LSO59_03590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LSO59_03670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LSO59_03675	COG1129	ABC transporter
LSO59_03675	COG0842	Transport permease protein
LSO59_03680	COG0842	Transport permease protein
LSO59_03685	COG1283	sodium-dependent phosphate transmembrane transporter activity
LSO59_03730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LSO59_03780	COG1477	protein flavinylation
LSO59_03790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LSO59_03805	COG0745	RESPONSE REGULATOR receiver
LSO59_03845	COG1230	cation diffusion facilitator family transporter
LSO59_03865	COG0789	Transcriptional regulator
LSO59_03870	COG0697	spore germination
LSO59_03900	COG3706	GGDEF domain
LSO59_03905	COG2205	protein histidine kinase activity
LSO59_03910	COG3293	Transposase
LSO59_03915	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LSO59_03930	COG0726	polysaccharide deacetylase
LSO59_03935	COG0438	transferase activity, transferring glycosyl groups
LSO59_03945	COG0438	transferase activity, transferring glycosyl groups
LSO59_03960	COG1442	glycosyl transferase family 8
LSO59_03975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LSO59_04025	COG1960	acyl-CoA dehydrogenase activity
LSO59_04030	COG1960	acyl-CoA dehydrogenase activity
LSO59_04040	COG2205	protein histidine kinase activity
LSO59_04045	COG0745	RESPONSE REGULATOR receiver
LSO59_04050	COG2315	Protein conserved in bacteria
LSO59_04070	COG3956	TIGRFAM MazG family protein
LSO59_04075	COG1555	photosystem II stabilization
LSO59_04080	COG0617	tRNA 3'-terminal CCA addition
LSO59_04085	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LSO59_04095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LSO59_04100	COG1660	Displays ATPase and GTPase activities
LSO59_04105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LSO59_04110	COG3028	Belongs to the UPF0307 family
LSO59_04115	COG0318	PFAM AMP-dependent synthetase and ligase
LSO59_04120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LSO59_04130	COG0625	glutathione transferase activity
LSO59_04135	COG1238	metal cluster binding
LSO59_04150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LSO59_04175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LSO59_04180	COG0072	phenylalanine-tRNA ligase activity
LSO59_04185	COG0776	regulation of translation
LSO59_04205	COG0248	Ppx GppA phosphatase
LSO59_04215	COG0037	tRNA processing
LSO59_04255	COG1846	Transcriptional regulator
LSO59_04260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LSO59_04320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LSO59_04325	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LSO59_04335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LSO59_04405	COG1214	PFAM Peptidase M22, glycoprotease
LSO59_04410	COG1968	undecaprenyl-diphosphatase activity
LSO59_04415	COG0742	ribosomal rna small subunit methyltransferase
LSO59_04430	COG4269	membrane
LSO59_04445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LSO59_04470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LSO59_04530	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LSO59_04550	COG0732	type I restriction modification DNA specificity domain
LSO59_04560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LSO59_04570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LSO59_04570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LSO59_04575	COG0745	RESPONSE REGULATOR receiver
LSO59_04580	COG2205	protein histidine kinase activity
LSO59_04590	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LSO59_04595	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LSO59_04600	COG0649	NAD binding
LSO59_04600	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LSO59_04610	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LSO59_04625	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LSO59_04635	COG0713	ATP synthesis coupled electron transport
LSO59_04640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LSO59_04645	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LSO59_04655	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LSO59_04670	COG0583	DNA-binding transcription factor activity
LSO59_04690	COG0668	transmembrane transport
LSO59_04700	COG2081	HI0933 family
LSO59_04705	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LSO59_04725	COG2226	methyltransferase
LSO59_04730	COG1280	lysine exporter protein (LysE YggA)
LSO59_04765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LSO59_04770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LSO59_04770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LSO59_04780	COG0489	protein tyrosine kinase activity
LSO59_04785	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LSO59_04800	COG0717	Belongs to the dCTP deaminase family
LSO59_04845	COG4372	Transposase
LSO59_04860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LSO59_04865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LSO59_04870	COG0628	permease
LSO59_04895	COG0583	DNA-binding transcription factor activity
LSO59_04905	COG1902	pentaerythritol trinitrate reductase activity
LSO59_04905	COG0446	pyridine nucleotide-disulphide oxidoreductase
LSO59_04915	COG0582	viral genome integration into host DNA
LSO59_05025	COG2814	Major facilitator Superfamily
LSO59_05040	COG1230	cation diffusion facilitator family transporter
LSO59_05080	COG0601	transmembrane transport
LSO59_05085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LSO59_05105	COG1132	(ABC) transporter
LSO59_05110	COG1132	(ABC) transporter
LSO59_05130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LSO59_05145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LSO59_05150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LSO59_05155	COG3328	transposase activity
LSO59_05160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LSO59_05165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LSO59_05200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LSO59_05210	COG0583	DNA-binding transcription factor activity
LSO59_05215	COG0596	Alpha beta hydrolase
LSO59_05245	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
LSO59_05250	COG2301	Belongs to the HpcH HpaI aldolase family
LSO59_05255	COG1960	acyl-CoA dehydrogenase activity
LSO59_05260	COG0583	DNA-binding transcription factor activity
LSO59_05265	COG0477	Major facilitator Superfamily
LSO59_05280	COG0725	ABC transporter, periplasmic molybdate-binding protein
LSO59_05285	COG4149	molybdate abc transporter
LSO59_05290	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LSO59_05295	COG0183	Belongs to the thiolase family
LSO59_05300	COG2031	fatty acid transporter
LSO59_05315	COG0583	DNA-binding transcription factor activity
LSO59_05330	COG1028	Short-chain dehydrogenase reductase Sdr
LSO59_05345	COG1595	DNA-templated transcription, initiation
LSO59_05355	COG1629	transport
LSO59_05370	COG1960	acyl-CoA dehydrogenase activity
LSO59_05380	COG1012	belongs to the aldehyde dehydrogenase family
LSO59_05385	COG1024	Enoyl-CoA hydratase
LSO59_05390	COG2814	Major facilitator Superfamily
LSO59_05400	COG1309	transcriptional regulator
LSO59_05415	COG2072	flavoprotein involved in K transport
LSO59_05420	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LSO59_05425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LSO59_05445	COG1113	amino acid transport
LSO59_05460	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LSO59_05470	COG2267	carboxylic ester hydrolase activity
LSO59_05475	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LSO59_05500	COG2217	Heavy metal translocating P-type atpase
LSO59_05520	COG1028	Short-chain dehydrogenase reductase Sdr
LSO59_05550	COG3079	Belongs to the UPF0149 family
LSO59_05555	COG0006	proline dipeptidase activity
LSO59_05560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LSO59_05565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LSO59_05580	COG3107	peptidoglycan biosynthetic process
LSO59_05585	COG0792	nuclease activity
LSO59_05610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LSO59_05615	COG0741	lytic transglycosylase activity
LSO59_05615	COG0741	lytic transglycosylase activity
LSO59_05615	COG1388	LysM domain
LSO59_05615	COG1388	LysM domain
LSO59_05620	COG4166	transmembrane transport
LSO59_05625	COG4174	ABC transporter (Permease)
LSO59_05630	COG4239	(ABC) transporter, permease
LSO59_05635	COG4172	Belongs to the ABC transporter superfamily
LSO59_05655	COG2351	hydroxyisourate hydrolase activity
LSO59_05665	COG1187	pseudouridine synthase activity
LSO59_05675	COG1823	symporter activity
LSO59_05680	COG0384	phenazine biosynthesis protein PhzF
LSO59_05685	COG0038	chloride channel
LSO59_05690	COG0612	Peptidase, M16
LSO59_05745	COG1522	sequence-specific DNA binding
LSO59_05765	COG1802	Transcriptional regulator
LSO59_05800	COG0174	glutamine synthetase
LSO59_05815	COG0436	Aminotransferase
LSO59_05825	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LSO59_05840	COG0556	nucleotide-excision repair
LSO59_05845	COG3040	lipid binding
LSO59_05850	COG2962	Rard protein
LSO59_05875	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LSO59_05925	COG5377	YqaJ viral recombinase family
LSO59_06050	COG3328	transposase activity
LSO59_06170	COG3179	chitinase
LSO59_06200	COG2070	2-Nitropropane dioxygenase
LSO59_06205	COG0531	amino acid
LSO59_06210	COG4303	Ethanolamine ammonia lyase large subunit
LSO59_06215	COG4302	ethanolamine ammonia-lyase activity
LSO59_06220	COG0632	four-way junction helicase activity
LSO59_06245	COG1764	response to oxidative stress
LSO59_06250	COG2985	domain, Protein
LSO59_06260	COG1960	acyl-CoA dehydrogenase activity
LSO59_06280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LSO59_06290	COG2195	Cleaves the N-terminal amino acid of tripeptides
LSO59_06295	COG3022	response to hydroperoxide
LSO59_06340	COG1643	Atp-dependent helicase
LSO59_06350	COG0243	molybdopterin cofactor binding
LSO59_06355	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LSO59_06365	COG0833	amino acid
LSO59_06375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LSO59_06380	COG0418	dihydroorotase activity
LSO59_06385	COG2203	Gaf domain
LSO59_06385	COG3706	GGDEF domain
LSO59_06385	COG4251	negative regulation of phosphorylation
LSO59_06385	COG5001	Diguanylate cyclase
LSO59_06405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LSO59_06425	COG0823	Involved in the tonB-independent uptake of proteins
LSO59_06445	COG0824	Thioesterase
LSO59_06450	COG2255	four-way junction helicase activity
LSO59_06465	COG4521	taurine ABC transporter
LSO59_06470	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LSO59_06475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LSO59_06480	COG2175	clavaminate synthase activity
LSO59_06485	COG4993	Dehydrogenase
LSO59_06490	COG4628	conserved protein (DUF2132)
LSO59_06525	COG1538	Outer membrane efflux protein
LSO59_06530	COG1132	(ABC) transporter
LSO59_06560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LSO59_06565	COG3550	peptidyl-serine autophosphorylation
LSO59_06590	COG3756	Protein conserved in bacteria
LSO59_06630	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LSO59_06640	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LSO59_06645	COG1137	ATPase activity
LSO59_06660	COG1538	Outer membrane efflux protein
LSO59_06690	COG4122	O-methyltransferase activity
LSO59_06700	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LSO59_06710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LSO59_06720	COG4968	Prepilin-type N-terminal cleavage methylation domain
LSO59_06755	COG4969	Belongs to the N-Me-Phe pilin family
LSO59_06775	COG4372	Transposase
LSO59_06835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LSO59_06845	COG2175	clavaminate synthase activity
LSO59_06860	COG0024	Methionine aminopeptidase
LSO59_06865	COG0052	Belongs to the universal ribosomal protein uS2 family
LSO59_06870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LSO59_06905	COG2951	lytic endotransglycosylase activity
LSO59_06910	COG0772	Belongs to the SEDS family
LSO59_06920	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LSO59_06920	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LSO59_06925	COG0842	Transport permease protein
LSO59_06930	COG1131	(ABC) transporter
LSO59_06940	COG0582	viral genome integration into host DNA
LSO59_07045	COG3586	endonuclease activity
LSO59_07055	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LSO59_07055	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LSO59_07060	COG1401	restriction endodeoxyribonuclease activity
LSO59_07075	COG3177	Filamentation induced by cAMP protein fic
LSO59_07080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LSO59_07100	COG1136	(ABC) transporter
LSO59_07105	COG0640	Transcriptional regulator
LSO59_07125	COG0730	response to heat
LSO59_07130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LSO59_07160	COG0640	Transcriptional regulator
LSO59_07170	COG0798	PFAM Bile acid sodium symporter
LSO59_07175	COG0431	NADPH-dependent FMN reductase
LSO59_07190	COG0737	Belongs to the 5'-nucleotidase family
LSO59_07200	COG1785	Belongs to the alkaline phosphatase family
LSO59_07305	COG0745	RESPONSE REGULATOR receiver
LSO59_07310	COG2194	sulfuric ester hydrolase activity
LSO59_07320	COG0671	phosphoesterase, PA-phosphatase related
LSO59_07330	COG0589	response to stress
LSO59_07340	COG1686	Belongs to the peptidase S11 family
LSO59_07350	COG0352	thiamine-phosphate diphosphorylase activity
LSO59_07360	COG3193	protein, possibly involved in utilization of glycolate and propanediol
LSO59_07365	COG0564	pseudouridine synthase activity
LSO59_07375	COG0783	Belongs to the Dps family
LSO59_07380	COG1309	transcriptional regulator
LSO59_07400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LSO59_07405	COG0076	glutamate decarboxylase activity
LSO59_07410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LSO59_07415	COG0573	inorganic phosphate transmembrane transporter activity
LSO59_07425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LSO59_07430	COG0616	signal peptide processing
LSO59_07445	COG2915	High frequency lysogenization protein hflD homolog
LSO59_07450	COG0482	sulfurtransferase activity
LSO59_07460	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LSO59_07465	COG1686	Belongs to the peptidase S11 family
LSO59_07480	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LSO59_07490	COG0583	DNA-binding transcription factor activity
LSO59_07495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LSO59_07500	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LSO59_07520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LSO59_07525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LSO59_07530	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LSO59_07545	COG4716	Myosin-crossreactive antigen
LSO59_07555	COG3706	GGDEF domain
LSO59_07565	COG1960	acyl-CoA dehydrogenase activity
LSO59_07570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LSO59_07630	COG0513	Belongs to the DEAD box helicase family
LSO59_07640	COG0778	Nitroreductase
LSO59_07665	COG0167	dihydroorotate dehydrogenase activity
LSO59_07670	COG1286	toxin biosynthetic process
LSO59_07695	COG4783	chaperone-mediated protein folding
LSO59_07705	COG1610	YqeY-like protein
LSO59_07725	COG0537	adenosine 5'-monophosphoramidase activity
LSO59_07755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LSO59_07765	COG3100	YcgL domain-containing protein
LSO59_07775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LSO59_07790	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LSO59_07795	COG0360	Binds together with S18 to 16S ribosomal RNA
LSO59_07805	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LSO59_07810	COG1845	cytochrome c oxidase, subunit III
LSO59_07815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LSO59_07820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LSO59_07835	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LSO59_07840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LSO59_07850	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LSO59_07855	COG2890	protein-(glutamine-N5) methyltransferase activity
LSO59_07870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LSO59_07875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LSO59_07910	COG3042	response to heat
LSO59_07915	COG1968	undecaprenyl-diphosphatase activity
LSO59_07940	COG2207	Transcriptional regulator
LSO59_07945	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LSO59_07955	COG1960	acyl-CoA dehydrogenase activity
LSO59_07960	COG1960	acyl-CoA dehydrogenase activity
LSO59_07985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LSO59_07995	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LSO59_08000	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LSO59_08010	COG2205	protein histidine kinase activity
LSO59_08015	COG0745	RESPONSE REGULATOR receiver
LSO59_08025	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LSO59_08035	COG0729	surface antigen
LSO59_08090	COG2204	response regulator
LSO59_08095	COG3852	Histidine kinase
LSO59_08105	COG0528	UMP kinase activity
LSO59_08110	COG0233	cytoplasmic translational termination
LSO59_08115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LSO59_08120	COG0575	Belongs to the CDS family
LSO59_08145	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LSO59_08155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LSO59_08170	COG2137	regulation of response to DNA damage stimulus
LSO59_08180	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LSO59_08185	COG1011	Hydrolase
LSO59_08190	COG1218	3'(2'),5'-bisphosphate nucleotidase
LSO59_08200	COG3594	Acyltransferase
LSO59_08205	COG0268	Binds directly to 16S ribosomal RNA
LSO59_08210	COG0702	epimerase
LSO59_08215	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LSO59_08230	COG0069	glutamate synthase activity
LSO59_08235	COG2850	peptidyl-arginine hydroxylation
LSO59_08245	COG0424	maF-like protein
LSO59_08255	COG0126	phosphoglycerate kinase activity
LSO59_08265	COG0191	fructose-bisphosphate aldolase activity
LSO59_08270	COG0697	spore germination
LSO59_08305	COG3698	Phosphodiester glycosidase
LSO59_08315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LSO59_08320	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LSO59_08325	COG0506	proline dehydrogenase activity
LSO59_08325	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LSO59_08325	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LSO59_08335	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LSO59_08340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LSO59_08345	COG0477	Major facilitator Superfamily
LSO59_08350	COG2267	carboxylic ester hydrolase activity
LSO59_08360	COG0446	pyridine nucleotide-disulphide oxidoreductase
LSO59_08360	COG1902	pentaerythritol trinitrate reductase activity
LSO59_08380	COG0504	CTP synthase activity
LSO59_08390	COG0148	phosphopyruvate hydratase activity
LSO59_08400	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LSO59_08405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LSO59_08415	COG1116	anion transmembrane transporter activity
LSO59_08415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LSO59_08420	COG0745	RESPONSE REGULATOR receiver
LSO59_08425	COG2223	nitrite transmembrane transporter activity
LSO59_08430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LSO59_08435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LSO59_08440	COG0243	molybdopterin cofactor binding
LSO59_08450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LSO59_08465	COG0315	cyclic pyranopterin monophosphate synthase activity
LSO59_08465	COG0521	Mo-molybdopterin cofactor biosynthetic process
LSO59_08470	COG0303	'Molybdopterin
LSO59_08475	COG0725	ABC transporter, periplasmic molybdate-binding protein
LSO59_08485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSO59_08490	COG0697	spore germination
LSO59_08510	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LSO59_08515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LSO59_08535	COG2194	sulfuric ester hydrolase activity
LSO59_08545	COG1960	acyl-CoA dehydrogenase activity
LSO59_08585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LSO59_08595	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LSO59_08605	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LSO59_08610	COG0509	glycine decarboxylation via glycine cleavage system
LSO59_08625	COG1132	(ABC) transporter
LSO59_08630	COG0668	transmembrane transport
LSO59_08635	COG3122	Protein conserved in bacteria
LSO59_08650	COG0640	Transcriptional regulator
LSO59_08695	COG1538	Outer membrane efflux protein
LSO59_08700	COG1595	DNA-templated transcription, initiation
LSO59_08710	COG1027	Aspartate ammonia-lyase
LSO59_08715	COG0583	DNA-binding transcription factor activity
LSO59_08720	COG1846	Transcriptional regulator
LSO59_08730	COG3676	manually curated
LSO59_08740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LSO59_08745	COG1414	Transcriptional regulator
LSO59_08750	COG4993	Dehydrogenase
LSO59_08755	COG3659	wide pore channel activity
LSO59_08760	COG3420	alginic acid biosynthetic process
LSO59_08765	COG0710	3-dehydroquinate dehydratase activity
LSO59_08770	COG3485	protocatechuate 3,4-dioxygenase
LSO59_08775	COG3485	protocatechuate 3,4-dioxygenase
LSO59_08780	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LSO59_08785	COG2271	Major facilitator Superfamily
LSO59_08790	COG0596	Alpha beta hydrolase
LSO59_08795	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LSO59_08800	COG0183	Belongs to the thiolase family
LSO59_08805	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LSO59_08810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LSO59_08835	COG0583	DNA-binding transcription factor activity
LSO59_08840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LSO59_08845	COG0235	Class ii aldolase
LSO59_08850	COG1024	Enoyl-CoA hydratase
LSO59_08855	COG1960	acyl-CoA dehydrogenase activity
LSO59_08865	COG2814	Major facilitator Superfamily
LSO59_08875	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LSO59_08885	COG2814	Major facilitator Superfamily
LSO59_08890	COG2814	Major facilitator Superfamily
LSO59_08895	COG1960	acyl-CoA dehydrogenase activity
LSO59_08900	COG1024	Enoyl-CoA hydratase
LSO59_08905	COG1028	Short-chain dehydrogenase reductase Sdr
LSO59_08910	COG1250	3-hydroxyacyl-CoA dehydrogenase
LSO59_08915	COG0183	Belongs to the thiolase family
LSO59_08930	COG2814	Major facilitator Superfamily
LSO59_08950	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LSO59_08950	COG0644	oxidoreductase
LSO59_09005	COG0583	DNA-binding transcription factor activity
LSO59_09010	COG1380	Effector of murein hydrolase LrgA
LSO59_09015	COG1346	cytolysis
LSO59_09030	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LSO59_09045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LSO59_09055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LSO59_09065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LSO59_09110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LSO59_09115	COG2814	Major facilitator Superfamily
LSO59_09120	COG1960	acyl-CoA dehydrogenase activity
LSO59_09125	COG0583	DNA-binding transcription factor activity
LSO59_09135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LSO59_09140	COG0583	DNA-binding transcription factor activity
LSO59_09145	COG0024	Methionine aminopeptidase
LSO59_09205	COG2814	Major facilitator Superfamily
LSO59_09210	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LSO59_09220	COG0667	Aldo Keto reductase
LSO59_09230	COG1053	succinate dehydrogenase
LSO59_09235	COG1053	succinate dehydrogenase
LSO59_09250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LSO59_09270	COG1309	transcriptional regulator
LSO59_09275	COG3659	wide pore channel activity
LSO59_09295	COG1414	Transcriptional regulator
LSO59_09300	COG1028	Short-chain dehydrogenase reductase Sdr
LSO59_09305	COG3328	transposase activity
LSO59_09315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LSO59_09345	COG0822	iron-sulfur transferase activity
LSO59_09350	COG0316	Belongs to the HesB IscA family
LSO59_09380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LSO59_09400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LSO59_09405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LSO59_09410	COG1454	alcohol dehydrogenase
LSO59_09415	COG0824	Thioesterase
LSO59_09440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LSO59_09445	COG2030	dehydratase
LSO59_09450	COG1028	Short-chain dehydrogenase reductase Sdr
LSO59_09480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LSO59_09490	COG3135	benzoate transporter
LSO59_09500	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LSO59_09515	COG0589	response to stress
LSO59_09525	COG0308	aminopeptidase N
LSO59_09540	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LSO59_09545	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
LSO59_09555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LSO59_09560	COG1454	alcohol dehydrogenase
LSO59_09580	COG0505	Belongs to the CarA family
LSO59_09590	COG2353	YceI-like domain
LSO59_09605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LSO59_09610	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LSO59_09640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LSO59_09640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LSO59_09650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LSO59_09665	COG0582	viral genome integration into host DNA
LSO59_09725	COG0582	viral genome integration into host DNA
LSO59_09855	COG2193	ferroxidase activity
LSO59_09860	COG4774	siderophore transport
LSO59_09875	COG0217	transcriptional regulatory protein
LSO59_09890	COG1126	abc transporter atp-binding protein
LSO59_09895	COG0765	amino acid transport
LSO59_09900	COG0765	amino acid transport
LSO59_09925	COG0542	response to heat
LSO59_09930	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LSO59_09940	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LSO59_09955	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LSO59_09960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LSO59_09965	COG0569	domain protein
LSO59_09970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LSO59_09985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LSO59_09995	COG1585	Membrane protein implicated in regulation of membrane protease activity
LSO59_10010	COG1294	oxidase, subunit
LSO59_10015	COG4890	Cyd operon protein YbgT
LSO59_10035	COG0552	protein localization to endoplasmic reticulum
LSO59_10070	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LSO59_10070	COG0517	IMP dehydrogenase activity
LSO59_10075	COG0305	Participates in initiation and elongation during chromosome replication
LSO59_10080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LSO59_10095	COG1305	Transglutaminase-like
LSO59_10105	COG2308	Evidence 4 Homologs of previously reported genes of
LSO59_10115	COG0445	tRNA wobble uridine modification
LSO59_10140	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LSO59_10145	COG0138	bifunctional purine biosynthesis protein purh
LSO59_10155	COG1464	Belongs to the NlpA lipoprotein family
LSO59_10160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LSO59_10165	COG2011	ABC-type metal ion transport system permease component
LSO59_10205	COG0515	serine threonine protein kinase
LSO59_10205	COG2815	serine threonine protein kinase
LSO59_10240	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LSO59_10265	COG0730	response to heat
LSO59_10270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LSO59_10280	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LSO59_10295	COG1253	flavin adenine dinucleotide binding
LSO59_10315	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LSO59_10335	COG0284	orotidine-5'-phosphate decarboxylase activity
LSO59_10350	COG0776	regulation of translation
LSO59_10360	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LSO59_10415	COG0084	hydrolase, TatD family'
LSO59_10435	COG1663	tetraacyldisaccharide 4'-kinase activity
LSO59_10440	COG1132	(ABC) transporter
LSO59_10450	COG0811	peptide transport
LSO59_10455	COG1475	DNA binding
LSO59_10460	COG1192	Involved in chromosome partitioning
LSO59_10465	COG0357	Ribosomal RNA small subunit methyltransferase G
LSO59_10470	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LSO59_10480	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LSO59_10485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LSO59_10490	COG1923	regulation of RNA biosynthetic process
LSO59_10495	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LSO59_10500	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LSO59_10505	COG0802	atpase or kinase
LSO59_10510	COG0564	pseudouridine synthase activity
LSO59_10540	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LSO59_10550	COG2707	UPF0756 membrane protein
LSO59_10560	COG0583	DNA-binding transcription factor activity
LSO59_10570	COG2814	Major facilitator Superfamily
LSO59_10575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LSO59_10580	COG0471	metal ion transport
LSO59_10585	COG1012	belongs to the aldehyde dehydrogenase family
LSO59_10610	COG1464	Belongs to the NlpA lipoprotein family
LSO59_10615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LSO59_10620	COG2011	ABC-type metal ion transport system permease component
LSO59_10625	COG0012	GTP binding
LSO59_10630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LSO59_10650	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LSO59_10655	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LSO59_10680	COG0386	Belongs to the glutathione peroxidase family
LSO59_10685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LSO59_10690	COG0436	Aminotransferase
LSO59_10730	COG3706	GGDEF domain
LSO59_10755	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LSO59_10760	COG0596	Alpha beta hydrolase
LSO59_10770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LSO59_10780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LSO59_10790	COG0714	Associated with various cellular activities
LSO59_10795	COG2879	small protein
LSO59_10800	COG1966	Carbon starvation protein
LSO59_10805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LSO59_10810	COG1509	lysine 2,3-aminomutase activity
LSO59_10825	COG4625	pathogenesis
LSO59_10835	COG0602	queuosine metabolic process
LSO59_10840	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LSO59_10850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LSO59_10855	COG2353	YceI-like domain
LSO59_10860	COG1056	cytidyltransferase-related domain
LSO59_10860	COG1051	belongs to the nudix hydrolase family
LSO59_10865	COG1024	Enoyl-CoA hydratase
LSO59_10875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LSO59_10875	COG3323	Protein of unknown function (DUF1653)
LSO59_10885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LSO59_10885	COG0047	phosphoribosylformylglycinamidine synthase activity
LSO59_10895	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LSO59_10895	COG3008	intermembrane lipid transfer
LSO59_10900	COG2995	paraquat-inducible protein a
LSO59_10930	COG0540	Belongs to the ATCase OTCase family
LSO59_10935	COG0116	Belongs to the methyltransferase superfamily
LSO59_10935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LSO59_10960	COG1765	OsmC-like protein
LSO59_10970	COG0667	Aldo Keto reductase
LSO59_10985	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LSO59_10990	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LSO59_11005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LSO59_11020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LSO59_11035	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LSO59_11040	COG2252	PERMEase
LSO59_11050	COG0659	secondary active sulfate transmembrane transporter activity
LSO59_11060	COG1301	dicarboxylic acid transport
LSO59_11065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LSO59_11070	COG3139	Protein of unknown function (DUF1315)
LSO59_11075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LSO59_11080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LSO59_11090	COG0494	nUDIX hydrolase
LSO59_11100	COG0642	Histidine kinase
LSO59_11110	COG3111	PFAM Bacterial OB fold (BOF) protein
LSO59_11115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LSO59_11120	COG3706	GGDEF domain
LSO59_11125	COG1720	tRNA m6t6A37 methyltransferase activity
LSO59_11135	COG1335	isochorismatase
LSO59_11140	COG3384	dioxygenase
LSO59_11145	COG0826	peptidase U32
LSO59_11150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LSO59_11175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LSO59_11180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LSO59_11200	COG1301	dicarboxylic acid transport
LSO59_11210	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LSO59_11230	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LSO59_11235	COG1381	Involved in DNA repair and RecF pathway recombination
LSO59_11245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LSO59_11250	COG0571	ribonuclease III activity
LSO59_11260	COG0681	Belongs to the peptidase S26 family
LSO59_11265	COG0481	GTPase activity
LSO59_11275	COG0174	glutamine synthetase
LSO59_11280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LSO59_11290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LSO59_11295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LSO59_11300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LSO59_11305	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LSO59_11315	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LSO59_11320	COG4208	sulfate ABC transporter
LSO59_11325	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LSO59_11330	COG0583	DNA-binding transcription factor activity
LSO59_11335	COG0254	rRNA binding
LSO59_11350	COG1067	ATP-dependent peptidase activity
LSO59_11355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LSO59_11360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LSO59_11365	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LSO59_11370	COG0512	Glutamine amidotransferase of anthranilate synthase
LSO59_11375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LSO59_11380	COG0134	indole-3-glycerol-phosphate synthase activity
LSO59_11395	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LSO59_11395	COG3608	succinylglutamate desuccinylase aspartoacylase
LSO59_11400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LSO59_11410	COG0302	gtp cyclohydrolase
LSO59_11415	COG0586	Pfam SNARE associated Golgi protein
LSO59_11425	COG3739	integral membrane protein
LSO59_11430	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LSO59_11440	COG1741	Belongs to the pirin family
LSO59_11470	COG1203	CRISPR-associated helicase, Cas3
LSO59_11480	COG0475	glutathione-regulated potassium exporter activity
LSO59_11480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LSO59_11495	COG1012	belongs to the aldehyde dehydrogenase family
LSO59_11500	COG4638	Rieske (2fe-2S)
LSO59_11505	COG0657	acetylesterase activity
LSO59_11515	COG0473	3-isopropylmalate dehydrogenase activity
LSO59_11520	COG0583	DNA-binding transcription factor activity
LSO59_11530	COG0842	Transport permease protein
LSO59_11535	COG0842	Transport permease protein
LSO59_11540	COG1131	(ABC) transporter
LSO59_11555	COG0583	DNA-binding transcription factor activity
LSO59_11565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LSO59_11570	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LSO59_11580	COG0037	tRNA processing
LSO59_11585	COG0739	heme binding
LSO59_11585	COG0741	lytic transglycosylase activity
LSO59_11585	COG1196	nuclear chromosome segregation
LSO59_11590	COG0501	Belongs to the peptidase M48B family
LSO59_11600	COG2239	Acts as a magnesium transporter
LSO59_11605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LSO59_11630	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LSO59_11635	COG2188	Transcriptional regulator
LSO59_11645	COG1045	serine acetyltransferase
LSO59_11650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LSO59_11655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LSO59_11660	COG0459	protein refolding
LSO59_11665	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LSO59_11680	COG1597	lipid kinase activity
LSO59_11685	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LSO59_11710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LSO59_11730	COG1929	Belongs to the glycerate kinase type-1 family
LSO59_11750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LSO59_11755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LSO59_11760	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LSO59_11780	COG0505	Belongs to the CarA family
LSO59_11800	COG0589	response to stress
LSO59_11810	COG0589	response to stress
LSO59_11820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LSO59_11830	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LSO59_11835	COG4181	ATPase activity
LSO59_11845	COG0288	reversible hydration of carbon dioxide
LSO59_11860	COG4771	TonB-dependent receptor
LSO59_11865	COG4771	TonB-dependent receptor
LSO59_11885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LSO59_11905	COG0306	phosphate transporter
LSO59_11915	COG0653	protein targeting
LSO59_11940	COG2852	Protein conserved in bacteria
LSO59_11950	COG3293	Transposase
LSO59_11965	COG2223	nitrite transmembrane transporter activity
LSO59_11975	COG2066	Belongs to the glutaminase family
LSO59_11980	COG0242	peptide deformylase activity
LSO59_11985	COG0561	phosphatase activity
LSO59_12000	COG0400	carboxylic ester hydrolase activity
LSO59_12030	COG1215	transferase activity, transferring glycosyl groups
LSO59_12035	COG1649	PFAM Uncharacterised BCR, COG1649
LSO59_12035	COG0726	polysaccharide deacetylase
LSO59_12050	COG4681	YaeQ
LSO59_12060	COG0523	cobalamin synthesis protein
LSO59_12075	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LSO59_12075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LSO59_12095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LSO59_12110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LSO59_12115	COG1773	rubredoxin
LSO59_12120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LSO59_12130	COG0583	DNA-binding transcription factor activity
LSO59_12165	COG1733	regulation of RNA biosynthetic process
LSO59_12175	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LSO59_12180	COG1648	precorrin-2 dehydrogenase activity
LSO59_12180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LSO59_12185	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LSO59_12195	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LSO59_12205	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LSO59_12210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LSO59_12225	COG0671	phosphoesterase, PA-phosphatase related
LSO59_12230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LSO59_12240	COG1538	Outer membrane efflux protein
LSO59_12245	COG0393	Putative heavy-metal-binding
LSO59_12250	COG0393	Putative heavy-metal-binding
LSO59_12255	COG1028	Short-chain dehydrogenase reductase Sdr
LSO59_12265	COG0525	valine-tRNA ligase activity
LSO59_12275	COG0004	ammonium transporteR
LSO59_12290	COG0745	RESPONSE REGULATOR receiver
LSO59_12295	COG2814	Major facilitator Superfamily
LSO59_12305	COG1752	Esterase of the alpha-beta hydrolase superfamily
LSO59_12320	COG0142	geranyltranstransferase activity
LSO59_12330	COG2828	Protein conserved in bacteria
LSO59_12335	COG1113	amino acid transport
LSO59_12355	COG2333	competence protein COMEC
LSO59_12355	COG0658	competence protein
LSO59_12360	COG1136	(ABC) transporter
LSO59_12380	COG1671	Belongs to the UPF0178 family
LSO59_12640	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LSO59_12650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LSO59_12680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LSO59_12695	COG3384	dioxygenase
LSO59_12705	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LSO59_12710	COG2878	Part of a membrane complex involved in electron transport
LSO59_12715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LSO59_12725	COG0563	adenylate kinase activity
LSO59_12740	COG0768	penicillin binding
LSO59_12745	COG0742	ribosomal rna small subunit methyltransferase
LSO59_12770	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LSO59_12775	COG0830	nickel cation binding
LSO59_12780	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LSO59_12785	COG0804	urea catabolic process
LSO59_12790	COG0832	Belongs to the urease beta subunit family
LSO59_12795	COG0831	urea catabolic process
LSO59_12800	COG0829	nickel cation binding
LSO59_12815	COG3015	lipoprotein NlpE involved in copper resistance
LSO59_12835	COG1253	flavin adenine dinucleotide binding
LSO59_12845	COG1116	anion transmembrane transporter activity
LSO59_12865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LSO59_12875	COG0864	Transcriptional regulator
LSO59_12885	COG0439	Biotin carboxylase
LSO59_12925	COG2851	Citrate transporter
LSO59_12935	COG0175	sulfate reduction
LSO59_12940	COG1492	cobalamin metabolic process
LSO59_12975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LSO59_12985	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LSO59_13015	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LSO59_13055	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LSO59_13065	COG0193	aminoacyl-tRNA hydrolase activity
LSO59_13075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LSO59_13085	COG1054	Belongs to the UPF0176 family
LSO59_13100	COG0586	Pfam SNARE associated Golgi protein
LSO59_13105	COG0500	methyltransferase
LSO59_13130	COG0321	lipoyl(octanoyl) transferase activity
LSO59_13145	COG0531	amino acid
LSO59_13150	COG2321	neutral zinc metallopeptidase
LSO59_13155	COG2354	Protein conserved in bacteria
LSO59_13165	COG1585	Membrane protein implicated in regulation of membrane protease activity
LSO59_13170	COG2268	Band 7 protein
LSO59_13185	COG1215	transferase activity, transferring glycosyl groups
LSO59_13190	COG1649	PFAM Uncharacterised BCR, COG1649
LSO59_13190	COG0726	polysaccharide deacetylase
LSO59_13210	COG0045	succinate-CoA ligase (ADP-forming) activity
LSO59_13215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LSO59_13230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LSO59_13235	COG1053	succinate dehydrogenase
LSO59_13240	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LSO59_13245	COG2009	succinate dehydrogenase
LSO59_13255	COG1607	acyl-coa hydrolase
LSO59_13265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LSO59_13270	COG1309	transcriptional regulator
LSO59_13275	COG1012	belongs to the aldehyde dehydrogenase family
LSO59_13280	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LSO59_13305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LSO59_13310	COG1120	ATPase activity
LSO59_13325	COG0028	Belongs to the TPP enzyme family
LSO59_13330	COG1012	belongs to the aldehyde dehydrogenase family
LSO59_13335	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
LSO59_13340	COG1028	Short-chain dehydrogenase reductase Sdr
LSO59_13355	COG2271	Major facilitator Superfamily
LSO59_13360	COG0446	pyridine nucleotide-disulphide oxidoreductase
LSO59_13370	COG1028	Short-chain dehydrogenase reductase Sdr
LSO59_13390	COG1414	Transcriptional regulator
LSO59_13410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LSO59_13430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LSO59_13440	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LSO59_13450	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LSO59_13460	COG0084	hydrolase, TatD family'
LSO59_13475	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LSO59_13490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LSO59_13500	COG0028	Belongs to the TPP enzyme family
LSO59_13525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LSO59_13530	COG0577	efflux transmembrane transporter activity
LSO59_13530	COG1136	(ABC) transporter
LSO59_13545	COG2223	nitrite transmembrane transporter activity
LSO59_13575	COG0583	DNA-binding transcription factor activity
LSO59_13580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LSO59_13585	COG0436	Aminotransferase
LSO59_13590	COG1301	dicarboxylic acid transport
LSO59_13595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LSO59_13605	COG2223	nitrite transmembrane transporter activity
LSO59_13610	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LSO59_13650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSO59_13655	COG2814	Major facilitator Superfamily
LSO59_13660	COG1566	PFAM secretion protein HlyD family protein
LSO59_13665	COG2050	protein possibly involved in aromatic compounds catabolism
LSO59_13690	COG0420	3'-5' exonuclease activity
LSO59_13710	COG1968	undecaprenyl-diphosphatase activity
LSO59_13730	COG0735	belongs to the Fur family
LSO59_13735	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LSO59_13740	COG2914	Belongs to the UPF0125 (RnfH) family
LSO59_13755	COG0121	glutamine amidotransferase
LSO59_13765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LSO59_13770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LSO59_13775	COG0756	dUTP diphosphatase activity
LSO59_13785	COG2885	chlorophyll binding
LSO59_13790	COG0204	Acyl-transferase
LSO59_13800	COG0850	regulation of cytokinetic process
LSO59_13805	COG2894	cell division
LSO59_13810	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LSO59_13820	COG1280	lysine exporter protein (LysE YggA)
LSO59_13830	COG1674	ftsk spoiiie
LSO59_13830	COG0531	amino acid
LSO59_13835	COG0492	ferredoxin-NADP+ reductase activity
LSO59_13840	COG0500	methyltransferase
LSO59_13845	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LSO59_13850	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LSO59_13855	COG0456	acetyltransferase
LSO59_13865	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LSO59_13870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LSO59_13895	COG1981	membrane
LSO59_13915	COG0351	phosphomethylpyrimidine kinase
LSO59_13915	COG0352	thiamine-phosphate diphosphorylase activity
LSO59_13915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LSO59_13920	COG1733	regulation of RNA biosynthetic process
LSO59_13930	COG1652	LysM domain
LSO59_13940	COG1028	Short-chain dehydrogenase reductase Sdr
LSO59_13955	COG1399	metal-binding, possibly nucleic acid-binding protein
LSO59_13960	COG3101	peptidyl-lysine hydroxylation
LSO59_13965	COG0009	L-threonylcarbamoyladenylate synthase
LSO59_13975	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LSO59_13980	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LSO59_14000	COG4106	trans-aconitate 2-methyltransferase activity
LSO59_14010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LSO59_14010	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LSO59_14025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LSO59_14040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LSO59_14050	COG1196	nuclear chromosome segregation
LSO59_14060	COG0730	response to heat
LSO59_14065	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LSO59_14065	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LSO59_14075	COG3545	Serine hydrolase
LSO59_14080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LSO59_14090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LSO59_14105	COG3422	double-strand break repair
LSO59_14110	COG0494	nUDIX hydrolase
LSO59_14115	COG2824	Alkylphosphonate utilization operon protein PhnA
LSO59_14130	COG1752	Esterase of the alpha-beta hydrolase superfamily
LSO59_14135	COG1115	amino acid carrier protein
LSO59_14140	COG0786	glutamate:sodium symporter activity
LSO59_14155	COG2814	Major facilitator Superfamily
LSO59_14160	COG1289	transmembrane transporter activity
LSO59_14170	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LSO59_14215	COG1376	ErfK ybiS ycfS ynhG family protein
LSO59_14220	COG2832	Protein of unknown function (DUF454)
LSO59_14230	COG5510	response to toxic substance
LSO59_14235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LSO59_14250	COG0183	Belongs to the thiolase family
LSO59_14280	COG1956	GAF domain-containing protein
LSO59_14285	COG1607	acyl-coa hydrolase
LSO59_14345	COG2199	diguanylate cyclase activity
LSO59_14350	COG2885	chlorophyll binding
LSO59_14375	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LSO59_14380	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LSO59_14390	COG0653	protein targeting
LSO59_14395	COG0450	alkyl hydroperoxide reductase
LSO59_14415	COG0285	dihydrofolate synthase activity
LSO59_14420	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LSO59_14460	COG4206	TonB-dependent receptor
LSO59_14465	COG2096	Adenosyltransferase
LSO59_14485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LSO59_14505	COG0784	Response regulator, receiver
LSO59_14505	COG5002	protein histidine kinase activity
LSO59_14505	COG2205	protein histidine kinase activity
LSO59_14520	COG3622	Belongs to the hyi family
LSO59_14545	COG0740	serine-type endopeptidase activity
LSO59_14550	COG0544	peptidyl-prolyl cis-trans isomerase activity
LSO59_14555	COG4774	siderophore transport
LSO59_14560	COG3128	pkhd-type hydroxylase
LSO59_14565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LSO59_14570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LSO59_14575	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LSO59_14575	COG2813	Specifically methylates the guanine in position
LSO59_14585	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LSO59_14620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LSO59_14630	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LSO59_14670	COG0788	formyltetrahydrofolate deformylase activity
LSO59_14675	COG1309	transcriptional regulator
LSO59_14695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LSO59_14695	COG4651	solute:proton antiporter activity
LSO59_14715	COG0210	DNA helicase
LSO59_14725	COG5001	Diguanylate cyclase
LSO59_14725	COG4251	negative regulation of phosphorylation
LSO59_14725	COG3706	GGDEF domain
LSO59_14725	COG2203	Gaf domain
LSO59_14755	COG2900	Belongs to the SlyX family
LSO59_14760	COG0488	(ABC) transporter
LSO59_14770	COG1560	Kdo2-lipid A biosynthetic process
LSO59_14775	COG0438	transferase activity, transferring glycosyl groups
LSO59_14780	COG1301	dicarboxylic acid transport
LSO59_14815	COG0101	tRNA pseudouridine synthase activity
LSO59_14820	COG1028	Short-chain dehydrogenase reductase Sdr
LSO59_14830	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LSO59_14840	COG0473	3-isopropylmalate dehydrogenase activity
LSO59_14855	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LSO59_14870	COG0583	DNA-binding transcription factor activity
LSO59_14885	COG0494	nUDIX hydrolase
LSO59_14895	COG1960	acyl-CoA dehydrogenase activity
LSO59_14905	COG0753	catalase activity
LSO59_14910	COG4993	Dehydrogenase
LSO59_14925	COG0583	DNA-binding transcription factor activity
LSO59_14940	COG0564	pseudouridine synthase activity
LSO59_14945	COG1530	ribonuclease E activity
LSO59_14950	COG0318	PFAM AMP-dependent synthetase and ligase
LSO59_14965	COG0450	alkyl hydroperoxide reductase
LSO59_14970	COG0583	DNA-binding transcription factor activity
LSO59_14975	COG4221	oxidoreductase activity
LSO59_14985	COG1595	DNA-templated transcription, initiation
LSO59_14995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LSO59_15005	COG0534	Mate efflux family protein
LSO59_15020	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LSO59_15025	COG0254	rRNA binding
LSO59_15040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LSO59_15060	COG0493	'glutamate synthase
LSO59_15060	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LSO59_15070	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LSO59_15080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LSO59_15085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LSO59_15095	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LSO59_15105	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LSO59_15105	COG0644	oxidoreductase
LSO59_15120	COG0425	Belongs to the sulfur carrier protein TusA family
LSO59_15125	COG4535	Mg2 and Co2 transporter CorC
LSO59_15130	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LSO59_15135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LSO59_15155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LSO59_15165	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LSO59_15170	COG0484	heat shock protein binding
LSO59_15185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LSO59_15190	COG0598	Magnesium transport protein CorA
LSO59_15195	COG2841	Protein conserved in bacteria
LSO59_15200	COG1185	polyribonucleotide nucleotidyltransferase activity
LSO59_15205	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LSO59_15210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LSO59_15215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LSO59_15220	COG1074	ATP-dependent DNA helicase activity
LSO59_15225	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LSO59_15250	COG2226	methyltransferase
LSO59_15260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LSO59_15285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LSO59_15285	COG2111	Na H antiporter
LSO59_15290	COG1006	Multisubunit Na H antiporter MnhC subunit
LSO59_15295	COG0651	ATP synthesis coupled electron transport
LSO59_15300	COG1863	multisubunit Na H antiporter MnhE subunit
LSO59_15305	COG2212	antiporter activity
LSO59_15310	COG1320	monovalent cation:proton antiporter activity
LSO59_15325	COG0195	Participates in both transcription termination and antitermination
LSO59_15330	COG0779	Required for maturation of 30S ribosomal subunits
LSO59_15355	COG0149	triose-phosphate isomerase activity
LSO59_15375	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LSO59_15380	COG0237	dephospho-CoA kinase activity
LSO59_15390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LSO59_15395	COG3123	guanosine phosphorylase activity
LSO59_15400	COG0497	DNA recombination
LSO59_15405	COG1678	Uncharacterized ACR, COG1678
LSO59_15410	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LSO59_15425	COG1289	transmembrane transporter activity
LSO59_15435	COG1132	(ABC) transporter
LSO59_15445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LSO59_15445	COG2169	Transcriptional regulator
LSO59_15450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LSO59_15475	COG1024	Enoyl-CoA hydratase
LSO59_15475	COG1250	3-hydroxyacyl-CoA dehydrogenase
LSO59_15505	COG3307	-O-antigen
LSO59_15515	COG3307	-O-antigen
LSO59_15550	COG2226	methyltransferase
LSO59_15555	COG1132	(ABC) transporter
LSO59_15560	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LSO59_15575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LSO59_15580	COG2226	methyltransferase
LSO59_15595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LSO59_15600	COG0662	Cupin 2, conserved barrel domain protein
LSO59_15600	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LSO59_15695	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LSO59_15700	COG1704	LemA family
LSO59_15710	COG1028	Short-chain dehydrogenase reductase Sdr
LSO59_15715	COG0493	'glutamate synthase
LSO59_15720	COG0069	glutamate synthase activity
LSO59_15720	COG0070	glutamate synthase
LSO59_15720	COG0067	glutamate synthase
LSO59_15730	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LSO59_15735	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LSO59_15770	COG2226	methyltransferase
LSO59_15775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LSO59_15780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LSO59_15785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LSO59_15800	COG0275	rRNA processing
LSO59_15815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LSO59_15865	COG0488	(ABC) transporter
LSO59_15870	COG0028	Belongs to the TPP enzyme family
LSO59_15880	COG4221	oxidoreductase activity
LSO59_15910	COG0427	acetyl-CoA hydrolase
LSO59_15915	COG0456	acetyltransferase
LSO59_15945	COG0131	Imidazoleglycerol-phosphate dehydratase
LSO59_15950	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LSO59_15960	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LSO59_15970	COG1132	(ABC) transporter
LSO59_15975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LSO59_15980	COG0531	amino acid
LSO59_16000	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LSO59_16040	COG3158	transport of potassium into the cell
LSO59_16050	COG0582	viral genome integration into host DNA
LSO59_16070	COG0732	type I restriction modification DNA specificity domain
LSO59_16135	COG3177	Filamentation induced by cAMP protein fic
LSO59_16160	COG4372	Transposase
LSO59_16205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LSO59_16215	COG0179	Fumarylacetoacetate (FAA) hydrolase
LSO59_16230	COG2814	Major facilitator Superfamily
LSO59_16240	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LSO59_16275	COG3706	GGDEF domain
LSO59_16295	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LSO59_16305	COG1335	isochorismatase
LSO59_16340	COG1538	Outer membrane efflux protein
LSO59_16365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LSO59_16370	COG1113	amino acid transport
LSO59_16385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LSO59_16410	COG0277	FAD linked oxidase domain protein
LSO59_16415	COG1304	FMN binding
LSO59_16420	COG2186	Transcriptional regulator
LSO59_16425	COG1620	l-lactate permease
LSO59_16430	COG0583	DNA-binding transcription factor activity
LSO59_16435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LSO59_16450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LSO59_16465	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LSO59_16470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LSO59_16475	COG1216	Glycosyl transferase, family 2
LSO59_16490	COG1216	Glycosyl transferase, family 2
LSO59_16495	COG1216	Glycosyl transferase, family 2
LSO59_16510	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LSO59_16515	COG1596	polysaccharide export
LSO59_16545	COG3023	N-Acetylmuramoyl-L-alanine amidase
LSO59_16565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LSO59_16595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LSO59_16600	COG0546	phosphoglycolate phosphatase activity
LSO59_16605	COG1028	Short-chain dehydrogenase reductase Sdr
LSO59_16625	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LSO59_16625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LSO59_16630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LSO59_16635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LSO59_16640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LSO59_16645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LSO59_16650	COG1116	anion transmembrane transporter activity
LSO59_16660	COG2233	PERMEase
LSO59_16665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LSO59_16670	COG0251	oxidation-reduction process
LSO59_16675	COG1335	isochorismatase
LSO59_16680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LSO59_16685	COG1309	transcriptional regulator
LSO59_16690	COG0596	Alpha beta hydrolase
LSO59_16705	COG0196	riboflavin kinase activity
LSO59_16710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LSO59_16715	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LSO59_16720	COG1047	Peptidyl-prolyl cis-trans
LSO59_16795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LSO59_16800	COG0657	acetylesterase activity
LSO59_16820	COG0583	DNA-binding transcription factor activity
LSO59_16825	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LSO59_16830	COG0443	Heat shock 70 kDa protein
LSO59_16845	COG2951	lytic endotransglycosylase activity
LSO59_16850	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LSO59_16865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LSO59_16890	COG0861	Integral membrane protein TerC family
LSO59_16900	COG0402	S-adenosylhomocysteine deaminase activity
LSO59_16915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LSO59_16925	COG0706	membrane insertase activity
LSO59_16930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LSO59_16935	COG0594	ribonuclease P activity
LSO59_17130	COG1192	Involved in chromosome partitioning
LSO59_17135	COG1475	DNA binding
LSO59_17310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LSO59_17435	COG4372	Transposase
LSO59_17510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LSO59_17585	COG2826	transposase and inactivated derivatives, IS30 family
LSO59_17725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LSO59_17775	COG1525	nuclease
LSO59_17785	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LSO59_17790	COG3421	Type III restriction
LSO59_17835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LSO59_17940	COG0860	N-Acetylmuramoyl-L-alanine amidase
LSO59_18010	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LSO59_18050	COG0488	(ABC) transporter
LSO59_18055	COG3173	Aminoglycoside phosphotransferase
LSO59_18070	COG2205	protein histidine kinase activity
LSO59_18075	COG0745	RESPONSE REGULATOR receiver
LSO59_18085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LSO59_18090	COG1538	Outer membrane efflux protein
LSO59_18100	COG5002	protein histidine kinase activity
LSO59_18165	COG1660	Displays ATPase and GTPase activities
LSO59_18330	COG2801	Transposase and inactivated derivatives
LSO59_18400	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LSO59_18470	COG5002	protein histidine kinase activity
LSO59_18490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LSO59_18500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LSO59_18500	COG0446	pyridine nucleotide-disulphide oxidoreductase
LSO59_18510	COG0004	ammonium transporteR
LSO59_18515	COG0004	ammonium transporteR
LSO59_18530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LSO59_18535	COG2218	PFAM glutamate synthase alpha subunit domain protein
LSO59_18540	COG0069	glutamate synthase activity
LSO59_18545	COG0582	viral genome integration into host DNA
LSO59_18790	COG0604	alcohol dehydrogenase
LSO59_18795	COG1309	transcriptional regulator
LSO59_18840	COG1570	exodeoxyribonuclease VII activity
LSO59_18855	COG1877	trehalose-phosphatase activity
LSO59_18860	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LSO59_18865	COG2223	nitrite transmembrane transporter activity
LSO59_18910	COG2323	membrane
LSO59_18930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LSO59_18995	COG1192	Involved in chromosome partitioning
LSO59_19000	COG1475	DNA binding
LSO59_19065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LSO59_19070	COG3850	Histidine kinase
LSO59_19075	COG2197	response regulator
LSO59_19095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LSO59_19105	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LSO59_19110	COG0347	Belongs to the P(II) protein family
LSO59_19230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LSO59_19265	COG2369	cell adhesion
LSO59_19270	COG0582	viral genome integration into host DNA
LSO59_19275	COG0697	spore germination
LSO59_19280	COG1113	amino acid transport
LSO59_19285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LSO59_19295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSO59_19330	COG3604	Transcriptional regulator
LSO59_19355	COG2144	transferase activity, transferring acyl groups
LSO59_19365	COG2072	flavoprotein involved in K transport
LSO59_19375	COG0542	response to heat
LSO59_19420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LSO59_19440	COG3264	Mechanosensitive ion channel
LSO59_19440	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LSO59_19480	COG2132	Multicopper oxidase
LSO59_19495	COG2205	protein histidine kinase activity
LSO59_19515	COG2217	Heavy metal translocating P-type atpase
LSO59_19600	COG0583	DNA-binding transcription factor activity
LSO59_19620	COG2233	PERMEase
LSO59_19630	COG0583	DNA-binding transcription factor activity
LSO59_19650	COG0492	ferredoxin-NADP+ reductase activity
LSO59_19655	COG0431	NADPH-dependent FMN reductase
LSO59_19660	COG0798	PFAM Bile acid sodium symporter
LSO59_19670	COG0640	Transcriptional regulator