locus-tag	class	description
LA331_00035	COG0833	amino acid
LA331_00045	COG0833	amino acid
LA331_00060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LA331_00065	COG0418	dihydroorotase activity
LA331_00070	COG3706	GGDEF domain
LA331_00085	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA331_00085	COG1902	pentaerythritol trinitrate reductase activity
LA331_00105	COG1785	Belongs to the alkaline phosphatase family
LA331_00110	COG1785	Belongs to the alkaline phosphatase family
LA331_00155	COG0281	malic enzyme
LA331_00190	COG1741	Belongs to the pirin family
LA331_00205	COG3739	integral membrane protein
LA331_00220	COG3706	GGDEF domain
LA331_00235	COG0302	gtp cyclohydrolase
LA331_00255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LA331_00260	COG0512	Glutamine amidotransferase of anthranilate synthase
LA331_00270	COG0174	glutamine synthetase
LA331_00285	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LA331_00330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LA331_00335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LA331_00340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LA331_00350	COG0596	Alpha beta hydrolase
LA331_00355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LA331_00360	COG1335	isochorismatase
LA331_00365	COG0251	oxidation-reduction process
LA331_00370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LA331_00375	COG2233	PERMEase
LA331_00380	COG2084	Dehydrogenase
LA331_00390	COG1960	acyl-CoA dehydrogenase activity
LA331_00395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LA331_00410	COG2721	sulfolactate sulfo-lyase activity
LA331_00460	COG0556	nucleotide-excision repair
LA331_00465	COG3040	lipid binding
LA331_00480	COG1733	regulation of RNA biosynthetic process
LA331_00500	COG0671	phosphoesterase, PA-phosphatase related
LA331_00510	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LA331_00515	COG0076	glutamate decarboxylase activity
LA331_00530	COG1522	sequence-specific DNA binding
LA331_00535	COG3961	Belongs to the TPP enzyme family
LA331_00540	COG1113	amino acid transport
LA331_00545	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LA331_00550	COG0573	inorganic phosphate transmembrane transporter activity
LA331_00560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LA331_00570	COG0616	signal peptide processing
LA331_00600	COG0482	sulfurtransferase activity
LA331_00610	COG2755	lipolytic protein G-D-S-L family
LA331_00610	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LA331_00625	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LA331_00630	COG1686	Belongs to the peptidase S11 family
LA331_00655	COG0583	DNA-binding transcription factor activity
LA331_00660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LA331_00665	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LA331_00670	COG1067	ATP-dependent peptidase activity
LA331_00705	COG1509	lysine 2,3-aminomutase activity
LA331_00710	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LA331_00715	COG1966	Carbon starvation protein
LA331_00720	COG2879	small protein
LA331_00725	COG0714	Associated with various cellular activities
LA331_00755	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LA331_00760	COG1765	OsmC-like protein
LA331_00770	COG0667	Aldo Keto reductase
LA331_00795	COG0540	Belongs to the ATCase OTCase family
LA331_00810	COG2031	fatty acid transporter
LA331_00815	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LA331_00830	COG4770	biotin carboxylase activity
LA331_00835	COG1024	Enoyl-CoA hydratase
LA331_00840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LA331_00845	COG1960	acyl-CoA dehydrogenase activity
LA331_00850	COG1309	transcriptional regulator
LA331_00855	COG0318	PFAM AMP-dependent synthetase and ligase
LA331_00875	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LA331_00880	COG0659	secondary active sulfate transmembrane transporter activity
LA331_00890	COG2249	NAD(P)H dehydrogenase (quinone) activity
LA331_00915	COG2363	Small membrane protein
LA331_00935	COG0513	Belongs to the DEAD box helicase family
LA331_00945	COG0778	Nitroreductase
LA331_00995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LA331_01000	COG4783	chaperone-mediated protein folding
LA331_01010	COG1610	YqeY-like protein
LA331_01025	COG2203	Gaf domain
LA331_01025	COG2199	diguanylate cyclase activity
LA331_01095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LA331_01110	COG0612	Peptidase, M16
LA331_01130	COG3025	triphosphatase activity
LA331_01145	COG0352	thiamine-phosphate diphosphorylase activity
LA331_01190	COG2267	carboxylic ester hydrolase activity
LA331_01250	COG2391	methyltransferase activity
LA331_01270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LA331_01290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LA331_01290	COG0519	Catalyzes the synthesis of GMP from XMP
LA331_01295	COG0625	glutathione transferase activity
LA331_01340	COG0517	IMP dehydrogenase activity
LA331_01340	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LA331_01345	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LA331_01355	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LA331_01360	COG1137	ATPase activity
LA331_01395	COG4122	O-methyltransferase activity
LA331_01405	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LA331_01440	COG2011	ABC-type metal ion transport system permease component
LA331_01445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LA331_01450	COG1464	Belongs to the NlpA lipoprotein family
LA331_01465	COG0138	bifunctional purine biosynthesis protein purh
LA331_01470	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LA331_01500	COG0445	tRNA wobble uridine modification
LA331_01515	COG3852	Histidine kinase
LA331_01535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LA331_01540	COG0575	Belongs to the CDS family
LA331_01555	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA331_01570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LA331_01575	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LA331_01590	COG2137	regulation of response to DNA damage stimulus
LA331_01600	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LA331_01605	COG1011	Hydrolase
LA331_01625	COG0268	Binds directly to 16S ribosomal RNA
LA331_01630	COG0702	epimerase
LA331_01635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LA331_01650	COG4585	Histidine kinase
LA331_01655	COG2850	peptidyl-arginine hydroxylation
LA331_01660	COG0424	maF-like protein
LA331_01685	COG0697	spore germination
LA331_01720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LA331_01725	COG3781	membrane
LA331_01745	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LA331_01745	COG0506	proline dehydrogenase activity
LA331_01745	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LA331_01755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LA331_01760	COG1027	Aspartate ammonia-lyase
LA331_01770	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LA331_01800	COG0316	Belongs to the HesB IscA family
LA331_01805	COG0822	iron-sulfur transferase activity
LA331_01815	COG1959	2 iron, 2 sulfur cluster binding
LA331_01835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LA331_01855	COG1585	Membrane protein implicated in regulation of membrane protease activity
LA331_01865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA331_01885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LA331_01890	COG0569	domain protein
LA331_01895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LA331_01900	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LA331_01920	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LA331_01925	COG0542	response to heat
LA331_01955	COG0372	Belongs to the citrate synthase family
LA331_01985	COG4680	protein conserved in bacteria
LA331_01990	COG5499	transcription regulator containing HTH domain
LA331_02000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LA331_02040	COG4372	Transposase
LA331_02045	COG2814	Major facilitator Superfamily
LA331_02055	COG3706	GGDEF domain
LA331_02065	COG0439	Biotin carboxylase
LA331_02080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LA331_02115	COG0582	viral genome integration into host DNA
LA331_02150	COG3723	Recombinational DNA repair protein, rece pathway
LA331_02175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LA331_02230	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
LA331_02275	COG3728	DNA packaging
LA331_02280	COG1783	phage Terminase large subunit
LA331_02375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LA331_02415	COG0596	Alpha beta hydrolase
LA331_02455	COG0830	nickel cation binding
LA331_02485	COG0804	urea catabolic process
LA331_02505	COG2351	hydroxyisourate hydrolase activity
LA331_02510	COG2233	PERMEase
LA331_02525	COG4266	Belongs to the allantoicase family
LA331_02530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LA331_02540	COG0583	DNA-binding transcription factor activity
LA331_02555	COG2826	transposase and inactivated derivatives, IS30 family
LA331_02565	COG3845	ABC transporter
LA331_02575	COG1079	Belongs to the binding-protein-dependent transport system permease family
LA331_02580	COG0402	S-adenosylhomocysteine deaminase activity
LA331_02600	COG4772	TonB-dependent receptor
LA331_02630	COG1289	transmembrane transporter activity
LA331_02640	COG0583	DNA-binding transcription factor activity
LA331_02680	COG2132	Multicopper oxidase
LA331_02705	COG0640	Transcriptional regulator
LA331_02715	COG1028	Short-chain dehydrogenase reductase Sdr
LA331_02730	COG0318	PFAM AMP-dependent synthetase and ligase
LA331_02750	COG1960	acyl-CoA dehydrogenase activity
LA331_02760	COG1024	Enoyl-CoA hydratase
LA331_02765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LA331_02770	COG0235	Class ii aldolase
LA331_02780	COG0183	Belongs to the thiolase family
LA331_02785	COG1250	3-hydroxyacyl-CoA dehydrogenase
LA331_02795	COG2814	Major facilitator Superfamily
LA331_02805	COG2814	Major facilitator Superfamily
LA331_02810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LA331_02815	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LA331_02820	COG2814	Major facilitator Superfamily
LA331_02825	COG1960	acyl-CoA dehydrogenase activity
LA331_02830	COG1960	acyl-CoA dehydrogenase activity
LA331_02840	COG1944	ATP diphosphatase activity
LA331_02860	COG1309	transcriptional regulator
LA331_02865	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LA331_02890	COG1116	anion transmembrane transporter activity
LA331_02890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LA331_02895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA331_02900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LA331_02925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA331_02935	COG0864	Transcriptional regulator
LA331_02940	COG2026	Addiction module toxin, RelE StbE family
LA331_02965	COG0439	Biotin carboxylase
LA331_02980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA331_03000	COG0318	PFAM AMP-dependent synthetase and ligase
LA331_03010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LA331_03020	COG2814	Major facilitator Superfamily
LA331_03025	COG3293	Transposase
LA331_03030	COG0583	DNA-binding transcription factor activity
LA331_03035	COG4948	Mandelate Racemase Muconate Lactonizing
LA331_03040	COG4829	muconolactone delta-isomerase
LA331_03050	COG4638	Rieske (2fe-2S)
LA331_03055	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LA331_03060	COG0543	2 iron, 2 sulfur cluster binding
LA331_03060	COG0633	Ferredoxin
LA331_03065	COG1028	Short-chain dehydrogenase reductase Sdr
LA331_03070	COG3135	benzoate transporter
LA331_03075	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LA331_03080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LA331_03085	COG0183	Belongs to the thiolase family
LA331_03090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LA331_03120	COG0183	Belongs to the thiolase family
LA331_03125	COG1960	acyl-CoA dehydrogenase activity
LA331_03140	COG0789	Transcriptional regulator
LA331_03150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LA331_03155	COG0640	Transcriptional regulator
LA331_03175	COG3122	Protein conserved in bacteria
LA331_03185	COG0668	transmembrane transport
LA331_03190	COG1132	(ABC) transporter
LA331_03200	COG0509	glycine decarboxylation via glycine cleavage system
LA331_03205	COG2814	Major facilitator Superfamily
LA331_03220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LA331_03235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LA331_03290	COG1525	nuclease
LA331_03300	COG1294	oxidase, subunit
LA331_03305	COG1271	oxidase subunit
LA331_03320	COG1476	TRANSCRIPTIONal
LA331_03335	COG1960	acyl-CoA dehydrogenase activity
LA331_03340	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA331_03345	COG2207	Transcriptional regulator
LA331_03350	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LA331_03355	COG0730	response to heat
LA331_03360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LA331_03430	COG1960	acyl-CoA dehydrogenase activity
LA331_03435	COG1960	acyl-CoA dehydrogenase activity
LA331_03500	COG0552	protein localization to endoplasmic reticulum
LA331_03505	COG0612	Peptidase, M16
LA331_03535	COG0516	GMP reductase activity
LA331_03535	COG0517	IMP dehydrogenase activity
LA331_03540	COG0133	tryptophan synthase activity
LA331_03550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LA331_03570	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LA331_03620	COG1294	oxidase, subunit
LA331_03625	COG4890	Cyd operon protein YbgT
LA331_03640	COG0772	Belongs to the SEDS family
LA331_03655	COG0148	phosphopyruvate hydratase activity
LA331_03685	COG1902	pentaerythritol trinitrate reductase activity
LA331_03685	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA331_03700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LA331_03705	COG0583	DNA-binding transcription factor activity
LA331_03710	COG0024	Methionine aminopeptidase
LA331_03735	COG0786	glutamate:sodium symporter activity
LA331_03770	COG1570	exodeoxyribonuclease VII activity
LA331_03785	COG0729	surface antigen
LA331_03790	COG0477	Major facilitator Superfamily
LA331_03810	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LA331_03820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LA331_03835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LA331_03860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LA331_03865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LA331_03870	COG2890	protein-(glutamine-N5) methyltransferase activity
LA331_03875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LA331_03890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LA331_03915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LA331_03920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LA331_03925	COG1845	cytochrome c oxidase, subunit III
LA331_03930	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LA331_03940	COG0360	Binds together with S18 to 16S ribosomal RNA
LA331_03955	COG0305	Participates in initiation and elongation during chromosome replication
LA331_03960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LA331_03975	COG1305	Transglutaminase-like
LA331_03985	COG2308	Evidence 4 Homologs of previously reported genes of
LA331_03995	COG0069	glutamate synthase activity
LA331_04015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LA331_04020	COG1454	alcohol dehydrogenase
LA331_04025	COG0824	Thioesterase
LA331_04055	COG0183	Belongs to the thiolase family
LA331_04070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LA331_04080	COG3135	benzoate transporter
LA331_04090	COG3293	Transposase
LA331_04100	COG0589	response to stress
LA331_04105	COG0589	response to stress
LA331_04115	COG0308	aminopeptidase N
LA331_04130	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LA331_04135	COG3293	Transposase
LA331_04140	COG1253	flavin adenine dinucleotide binding
LA331_04160	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LA331_04165	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LA331_04180	COG2431	L-lysine efflux transmembrane transporter activity
LA331_04200	COG0776	regulation of translation
LA331_04230	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LA331_04260	COG1309	transcriptional regulator
LA331_04265	COG0084	hydrolase, TatD family'
LA331_04285	COG1663	tetraacyldisaccharide 4'-kinase activity
LA331_04290	COG1132	(ABC) transporter
LA331_04300	COG0811	peptide transport
LA331_04310	COG1475	DNA binding
LA331_04315	COG1192	Involved in chromosome partitioning
LA331_04325	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LA331_04330	COG3178	'Phosphotransferase
LA331_04340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LA331_04345	COG1923	regulation of RNA biosynthetic process
LA331_04355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LA331_04360	COG0802	atpase or kinase
LA331_04385	COG2707	UPF0756 membrane protein
LA331_04390	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LA331_04410	COG1643	Atp-dependent helicase
LA331_04435	COG3634	alkyl hydroperoxide reductase activity
LA331_04470	COG1254	Belongs to the acylphosphatase family
LA331_04475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LA331_04475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LA331_04565	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LA331_04570	COG0582	viral genome integration into host DNA
LA331_04585	COG0542	response to heat
LA331_04610	COG3293	Transposase
LA331_04625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LA331_04630	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LA331_04630	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LA331_04735	COG4372	Transposase
LA331_04745	COG2963	transposase activity
LA331_04825	COG1464	Belongs to the NlpA lipoprotein family
LA331_04830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LA331_04840	COG0012	GTP binding
LA331_04845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LA331_04855	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LA331_04875	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LA331_04890	COG0386	Belongs to the glutathione peroxidase family
LA331_04895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LA331_04900	COG0436	Aminotransferase
LA331_04910	COG2755	lipolytic protein G-D-S-L family
LA331_04910	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LA331_04930	COG1187	pseudouridine synthase activity
LA331_04950	COG2351	hydroxyisourate hydrolase activity
LA331_04965	COG1686	Belongs to the peptidase S11 family
LA331_04970	COG1252	NADH dehydrogenase
LA331_04995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LA331_05025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LA331_05030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LA331_05035	COG0527	aspartate kinase activity
LA331_05045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LA331_05060	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LA331_05065	COG2252	PERMEase
LA331_05095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LA331_05100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LA331_05110	COG0693	protein deglycase activity
LA331_05115	COG1960	acyl-CoA dehydrogenase activity
LA331_05120	COG1301	dicarboxylic acid transport
LA331_05130	COG3139	Protein of unknown function (DUF1315)
LA331_05135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LA331_05140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LA331_05150	COG0494	nUDIX hydrolase
LA331_05160	COG0642	Histidine kinase
LA331_05175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LA331_05190	COG1720	tRNA m6t6A37 methyltransferase activity
LA331_05200	COG4993	Dehydrogenase
LA331_05235	COG0826	peptidase U32
LA331_05240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LA331_05245	COG3634	alkyl hydroperoxide reductase activity
LA331_05265	COG2862	Uncharacterized protein family, UPF0114
LA331_05270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LA331_05465	COG5410	chromosome segregation
LA331_05515	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
LA331_05675	COG1131	(ABC) transporter
LA331_05680	COG0842	Transport permease protein
LA331_05695	COG2951	lytic endotransglycosylase activity
LA331_05720	COG0052	Belongs to the universal ribosomal protein uS2 family
LA331_05730	COG0436	Aminotransferase
LA331_05770	COG4372	Transposase
LA331_05780	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LA331_05785	COG1381	Involved in DNA repair and RecF pathway recombination
LA331_05795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LA331_05800	COG0571	ribonuclease III activity
LA331_05825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LA331_05845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LA331_05855	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LA331_05860	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LA331_05870	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LA331_05875	COG4208	sulfate ABC transporter
LA331_05880	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LA331_05885	COG0583	DNA-binding transcription factor activity
LA331_05905	COG0602	queuosine metabolic process
LA331_05910	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LA331_05920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LA331_05925	COG1279	arginine transmembrane transporter activity
LA331_05930	COG0583	DNA-binding transcription factor activity
LA331_05935	COG2353	YceI-like domain
LA331_05940	COG1051	belongs to the nudix hydrolase family
LA331_05940	COG1056	cytidyltransferase-related domain
LA331_05945	COG1024	Enoyl-CoA hydratase
LA331_05950	COG0778	Nitroreductase
LA331_05970	COG0583	DNA-binding transcription factor activity
LA331_05980	COG0047	phosphoribosylformylglycinamidine synthase activity
LA331_05980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LA331_06005	COG2255	four-way junction helicase activity
LA331_06010	COG1473	amidohydrolase
LA331_06015	COG0824	Thioesterase
LA331_06035	COG0823	Involved in the tonB-independent uptake of proteins
LA331_06055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LA331_06085	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LA331_06090	COG0628	permease
LA331_06095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LA331_06100	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LA331_06105	COG2267	carboxylic ester hydrolase activity
LA331_06120	COG2333	competence protein COMEC
LA331_06120	COG0658	competence protein
LA331_06125	COG1136	(ABC) transporter
LA331_06145	COG1671	Belongs to the UPF0178 family
LA331_06170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA331_06210	COG1280	lysine exporter protein (LysE YggA)
LA331_06215	COG1522	sequence-specific DNA binding
LA331_06225	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LA331_06230	COG0596	Alpha beta hydrolase
LA331_06250	COG1113	amino acid transport
LA331_06255	COG1115	amino acid carrier protein
LA331_06275	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LA331_06310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LA331_06315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LA331_06320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LA331_06325	COG5001	Diguanylate cyclase
LA331_06325	COG1716	ATPase activity
LA331_06345	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LA331_06355	COG1960	acyl-CoA dehydrogenase activity
LA331_06360	COG0583	DNA-binding transcription factor activity
LA331_06375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LA331_06380	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LA331_06390	COG0037	tRNA processing
LA331_06395	COG1196	nuclear chromosome segregation
LA331_06395	COG0741	lytic transglycosylase activity
LA331_06395	COG0739	heme binding
LA331_06400	COG0501	Belongs to the peptidase M48B family
LA331_06410	COG2239	Acts as a magnesium transporter
LA331_06420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA331_06435	COG1253	flavin adenine dinucleotide binding
LA331_06470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LA331_06480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LA331_06485	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LA331_06510	COG0505	Belongs to the CarA family
LA331_06525	COG1309	transcriptional regulator
LA331_06530	COG0251	oxidation-reduction process
LA331_06535	COG0110	maltose O-acetyltransferase activity
LA331_06575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LA331_06600	COG0564	pseudouridine synthase activity
LA331_06610	COG0358	DNA primase activity
LA331_06615	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LA331_06625	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LA331_06655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LA331_06685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LA331_06710	COG0586	Pfam SNARE associated Golgi protein
LA331_06730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LA331_06740	COG0321	lipoyl(octanoyl) transferase activity
LA331_06755	COG0531	amino acid
LA331_06765	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LA331_06770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LA331_06770	COG1648	precorrin-2 dehydrogenase activity
LA331_06775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LA331_06785	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LA331_06795	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LA331_06810	COG0671	phosphoesterase, PA-phosphatase related
LA331_06815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA331_06825	COG1538	Outer membrane efflux protein
LA331_06830	COG0393	Putative heavy-metal-binding
LA331_06835	COG0393	Putative heavy-metal-binding
LA331_06840	COG0242	peptide deformylase activity
LA331_06875	COG2203	Gaf domain
LA331_06875	COG2199	diguanylate cyclase activity
LA331_06885	COG1285	pathogenesis
LA331_06895	COG0523	cobalamin synthesis protein
LA331_06915	COG2814	Major facilitator Superfamily
LA331_06925	COG1607	acyl-coa hydrolase
LA331_06935	COG1752	Esterase of the alpha-beta hydrolase superfamily
LA331_06940	COG2059	Chromate
LA331_06945	COG1115	amino acid carrier protein
LA331_06950	COG0786	glutamate:sodium symporter activity
LA331_06960	COG2814	Major facilitator Superfamily
LA331_06965	COG1289	transmembrane transporter activity
LA331_06975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LA331_07035	COG2832	Protein of unknown function (DUF454)
LA331_07065	COG0840	transmembrane signaling receptor activity
LA331_07135	COG2358	TRAP transporter, solute receptor (TAXI family
LA331_07150	COG0489	protein tyrosine kinase activity
LA331_07165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LA331_07165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LA331_07175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LA331_07180	COG0004	ammonium transporteR
LA331_07205	COG2081	HI0933 family
LA331_07220	COG0668	transmembrane transport
LA331_07240	COG0583	DNA-binding transcription factor activity
LA331_07270	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LA331_07275	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LA331_07280	COG0713	ATP synthesis coupled electron transport
LA331_07285	COG0839	Belongs to the complex I subunit 6 family
LA331_07290	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LA331_07305	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LA331_07325	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LA331_07335	COG2205	protein histidine kinase activity
LA331_07340	COG0745	RESPONSE REGULATOR receiver
LA331_07350	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA331_07360	COG3152	Membrane
LA331_07400	COG0351	phosphomethylpyrimidine kinase
LA331_07420	COG2824	Alkylphosphonate utilization operon protein PhnA
LA331_07440	COG0564	pseudouridine synthase activity
LA331_07485	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LA331_07490	COG2132	Multicopper oxidase
LA331_07495	COG0354	folic acid binding
LA331_07505	COG0679	Auxin Efflux Carrier
LA331_07510	COG1902	pentaerythritol trinitrate reductase activity
LA331_07525	COG2963	transposase activity
LA331_07535	COG4372	Transposase
LA331_07550	COG1217	gtp-binding protein TYPA
LA331_07555	COG2233	PERMEase
LA331_07565	COG0833	amino acid
LA331_07585	COG0183	Belongs to the thiolase family
LA331_07605	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LA331_07610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LA331_07615	COG2207	Transcriptional regulator
LA331_07620	COG0183	Belongs to the thiolase family
LA331_07625	COG1024	Enoyl-CoA hydratase
LA331_07625	COG1250	3-hydroxyacyl-CoA dehydrogenase
LA331_07650	COG1272	protein, Hemolysin III
LA331_07655	COG0477	Major facilitator Superfamily
LA331_07665	COG1408	metallophosphoesterase
LA331_07670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LA331_07685	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LA331_07715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LA331_07720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LA331_07730	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LA331_07735	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LA331_07740	COG0625	glutathione transferase activity
LA331_07745	COG2969	positive regulation of protein catabolic process
LA331_07820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LA331_07825	COG1764	response to oxidative stress
LA331_07865	COG0037	tRNA processing
LA331_07875	COG0248	Ppx GppA phosphatase
LA331_07900	COG0072	phenylalanine-tRNA ligase activity
LA331_07905	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LA331_07930	COG1238	metal cluster binding
LA331_07940	COG0625	glutathione transferase activity
LA331_07985	COG0318	PFAM AMP-dependent synthetase and ligase
LA331_07995	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LA331_08005	COG1704	LemA family
LA331_08020	COG1862	Preprotein translocase
LA331_08030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA331_08040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LA331_08055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LA331_08060	COG5002	protein histidine kinase activity
LA331_08060	COG2205	protein histidine kinase activity
LA331_08060	COG0784	Response regulator, receiver
LA331_08065	COG1024	Enoyl-CoA hydratase
LA331_08070	COG2084	Dehydrogenase
LA331_08075	COG3622	Belongs to the hyi family
LA331_08100	COG2814	Major facilitator Superfamily
LA331_08110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LA331_08120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LA331_08125	COG2003	Belongs to the UPF0758 family
LA331_08130	COG3781	membrane
LA331_08145	COG2350	Protein conserved in bacteria
LA331_08175	COG1607	acyl-coa hydrolase
LA331_08200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA331_08235	COG1183	phosphatidylcholine synthase activity
LA331_08240	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LA331_08280	COG0739	heme binding
LA331_08280	COG1196	nuclear chromosome segregation
LA331_08280	COG0741	lytic transglycosylase activity
LA331_08285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LA331_08290	COG1702	phosphate starvation-inducible protein PhoH
LA331_08340	COG1295	ribonuclease BN
LA331_08350	COG0179	Fumarylacetoacetate (FAA) hydrolase
LA331_08390	COG0557	exoribonuclease II activity
LA331_08400	COG0339	signal peptide processing
LA331_08405	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LA331_08415	COG0697	spore germination
LA331_08440	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LA331_08445	COG1960	acyl-CoA dehydrogenase activity
LA331_08450	COG2072	flavoprotein involved in K transport
LA331_08455	COG0203	ribosomal protein L17
LA331_08460	COG0202	RNA polymerase activity
LA331_08465	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LA331_08475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LA331_08500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LA331_08510	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LA331_08515	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LA331_08520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LA331_08565	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LA331_08580	COG0088	Forms part of the polypeptide exit tunnel
LA331_08585	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LA331_08600	COG0626	cystathionine gamma-synthase activity
LA331_08615	COG1959	2 iron, 2 sulfur cluster binding
LA331_08635	COG1301	dicarboxylic acid transport
LA331_08640	COG1946	Acyl-CoA thioesterase
LA331_08645	COG2937	Belongs to the GPAT DAPAT family
LA331_08655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LA331_08660	COG1040	competence protein
LA331_08675	COG0598	Magnesium transport protein CorA
LA331_08685	COG2854	intermembrane phospholipid transfer
LA331_08690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LA331_08695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LA331_08700	COG1127	ABC transporter
LA331_08705	COG4372	Transposase
LA331_08715	COG2963	transposase activity
LA331_08720	COG0513	Belongs to the DEAD box helicase family
LA331_08730	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LA331_08740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LA331_08745	COG0408	coproporphyrinogen oxidase activity
LA331_08760	COG1960	acyl-CoA dehydrogenase activity
LA331_08765	COG1278	Cold shock
LA331_08780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LA331_08790	COG0534	Mate efflux family protein
LA331_08800	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LA331_08805	COG0254	rRNA binding
LA331_08810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LA331_08845	COG0628	permease
LA331_08855	COG1289	transmembrane transporter activity
LA331_08860	COG2814	Major facilitator Superfamily
LA331_08880	COG0277	FAD linked oxidase domain protein
LA331_08885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LA331_08915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LA331_08920	COG5380	lipid catabolic process
LA331_08925	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LA331_08935	COG0335	large ribosomal subunit rRNA binding
LA331_08945	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LA331_08950	COG0228	four-way junction DNA binding
LA331_09000	COG0194	GDP metabolic process
LA331_09005	COG1758	RNA polymerase activity
LA331_09010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LA331_09030	COG3307	-O-antigen
LA331_09035	COG4969	Belongs to the N-Me-Phe pilin family
LA331_09055	COG1704	LemA family
LA331_09060	COG0493	'glutamate synthase
LA331_09065	COG0069	glutamate synthase activity
LA331_09065	COG0070	glutamate synthase
LA331_09065	COG0067	glutamate synthase
LA331_09115	COG2226	methyltransferase
LA331_09120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LA331_09125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LA331_09130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LA331_09150	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LA331_09160	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LA331_09195	COG0488	(ABC) transporter
LA331_09205	COG4221	oxidoreductase activity
LA331_09210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LA331_09225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LA331_09225	COG2111	Na H antiporter
LA331_09230	COG1006	Multisubunit Na H antiporter MnhC subunit
LA331_09235	COG0651	ATP synthesis coupled electron transport
LA331_09240	COG1863	multisubunit Na H antiporter MnhE subunit
LA331_09245	COG2212	antiporter activity
LA331_09250	COG1320	monovalent cation:proton antiporter activity
LA331_09255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LA331_09265	COG0195	Participates in both transcription termination and antitermination
LA331_09270	COG0779	Required for maturation of 30S ribosomal subunits
LA331_09305	COG0149	triose-phosphate isomerase activity
LA331_09325	COG0237	dephospho-CoA kinase activity
LA331_09335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LA331_09340	COG3123	guanosine phosphorylase activity
LA331_09345	COG0497	DNA recombination
LA331_09360	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LA331_09370	COG1132	(ABC) transporter
LA331_09420	COG0494	nUDIX hydrolase
LA331_09425	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LA331_09430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LA331_09435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LA331_09445	COG0772	Belongs to the SEDS family
LA331_09470	COG4974	Belongs to the 'phage' integrase family
LA331_09475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA331_09485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LA331_09490	COG1686	Belongs to the peptidase S11 family
LA331_09495	COG2197	response regulator
LA331_09500	COG2205	protein histidine kinase activity
LA331_09510	COG0793	Belongs to the peptidase S41A family
LA331_09515	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LA331_09520	COG0795	lipopolysaccharide-transporting ATPase activity
LA331_09525	COG0795	lipopolysaccharide-transporting ATPase activity
LA331_09545	COG0586	Pfam SNARE associated Golgi protein
LA331_09560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LA331_09560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LA331_09570	COG0004	ammonium transporteR
LA331_09575	COG0347	Belongs to the P(II) protein family
LA331_09585	COG0606	chelatase, subunit chli
LA331_09600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LA331_09615	COG0318	PFAM AMP-dependent synthetase and ligase
LA331_09625	COG0477	Major facilitator Superfamily
LA331_09630	COG2860	membrane
LA331_09640	COG1253	flavin adenine dinucleotide binding
LA331_09655	COG0477	Major facilitator Superfamily
LA331_09665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LA331_09670	COG0477	Major facilitator Superfamily
LA331_09690	COG2814	Major facilitator Superfamily
LA331_09750	COG0697	spore germination
LA331_09755	COG0386	Belongs to the glutathione peroxidase family
LA331_09775	COG1012	belongs to the aldehyde dehydrogenase family
LA331_09795	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LA331_09845	COG1121	(ABC) transporter
LA331_09850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LA331_09855	COG1683	Conserved Protein
LA331_09865	COG2837	iron assimilation
LA331_09885	COG0436	Aminotransferase
LA331_09890	COG0534	Mate efflux family protein
LA331_09945	COG3706	GGDEF domain
LA331_09950	COG3706	GGDEF domain
LA331_09955	COG1715	Restriction endonuclease
LA331_09960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LA331_09960	COG0519	Catalyzes the synthesis of GMP from XMP
LA331_09965	COG0586	Pfam SNARE associated Golgi protein
LA331_09980	COG1192	Involved in chromosome partitioning
LA331_10025	COG3756	Protein conserved in bacteria
LA331_10035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LA331_10050	COG0753	catalase activity
LA331_10115	COG3550	peptidyl-serine autophosphorylation
LA331_10120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LA331_10130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA331_10130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA331_10130	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LA331_10135	COG1105	Belongs to the carbohydrate kinase PfkB family
LA331_10140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LA331_10140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA331_10160	COG0737	Belongs to the 5'-nucleotidase family
LA331_10175	COG3540	Alkaline phosphatase
LA331_10195	COG4628	conserved protein (DUF2132)
LA331_10220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LA331_10230	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LA331_10235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LA331_10245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LA331_10275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LA331_10280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LA331_10295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LA331_10305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LA331_10315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LA331_10325	COG0463	Glycosyl transferase, family 2
LA331_10345	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LA331_10390	COG1194	a g-specific adenine glycosylase
LA331_10395	COG0739	heme binding
LA331_10405	COG2818	Glycosylase
LA331_10410	COG1064	alcohol dehydrogenase
LA331_10415	COG0583	DNA-binding transcription factor activity
LA331_10420	COG0656	L-ascorbic acid biosynthetic process
LA331_10425	COG2814	Major facilitator Superfamily
LA331_10475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA331_10490	COG2233	PERMEase
LA331_10515	COG0129	dihydroxy-acid dehydratase activity
LA331_10525	COG0129	dihydroxy-acid dehydratase activity
LA331_10540	COG0428	transporter
LA331_10550	COG0733	neurotransmitter:sodium symporter activity
LA331_10555	COG1012	belongs to the aldehyde dehydrogenase family
LA331_10565	COG0693	protein deglycase activity
LA331_10570	COG0666	response to abiotic stimulus
LA331_10585	COG2814	Major facilitator Superfamily
LA331_10590	COG2814	Major facilitator Superfamily
LA331_10620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LA331_10630	COG0657	acetylesterase activity
LA331_10685	COG0488	(ABC) transporter
LA331_10690	COG1063	alcohol dehydrogenase
LA331_10700	COG0187	DNA topoisomerase II activity
LA331_10710	COG0592	DNA-directed DNA polymerase activity
LA331_10715	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LA331_10730	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LA331_10735	COG0706	membrane insertase activity
LA331_10745	COG0582	viral genome integration into host DNA
LA331_10810	COG4372	Transposase
LA331_10845	COG0675	Transposase, IS605 OrfB family
LA331_10870	COG0402	S-adenosylhomocysteine deaminase activity
LA331_10875	COG0861	Integral membrane protein TerC family
LA331_10880	COG2814	Major facilitator Superfamily
LA331_10925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LA331_10940	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LA331_10945	COG2951	lytic endotransglycosylase activity
LA331_10950	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LA331_10955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LA331_11000	COG5001	Diguanylate cyclase
LA331_11000	COG2203	Gaf domain
LA331_11000	COG3706	GGDEF domain
LA331_11000	COG4251	negative regulation of phosphorylation
LA331_11005	COG2133	pyrroloquinoline quinone binding
LA331_11025	COG1047	Peptidyl-prolyl cis-trans
LA331_11035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LA331_11040	COG0196	riboflavin kinase activity
LA331_11050	COG1309	transcriptional regulator
LA331_11055	COG1116	anion transmembrane transporter activity
LA331_11060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LA331_11065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LA331_11070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LA331_11075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LA331_11080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LA331_11080	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LA331_11110	COG1028	Short-chain dehydrogenase reductase Sdr
LA331_11115	COG0546	phosphoglycolate phosphatase activity
LA331_11120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LA331_11125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA331_11130	COG1309	transcriptional regulator
LA331_11135	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LA331_11145	COG3023	N-Acetylmuramoyl-L-alanine amidase
LA331_11155	COG5487	UPF0391 membrane protein
LA331_11160	COG2983	Belongs to the UPF0260 family
LA331_11165	COG3300	MHYT domain
LA331_11165	COG5001	Diguanylate cyclase
LA331_11170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LA331_11175	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LA331_11185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LA331_11195	COG1335	isochorismatase
LA331_11200	COG0385	Bile acid
LA331_11215	COG0560	Phosphoserine phosphatase
LA331_11215	COG3830	Belongs to the UPF0237 family
LA331_11235	COG0753	catalase activity
LA331_11275	COG2733	membrane
LA331_11290	COG2918	glutathione biosynthetic process
LA331_11295	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LA331_11305	COG3150	esterase
LA331_11355	COG3706	GGDEF domain
LA331_11365	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LA331_11385	COG0708	Exodeoxyribonuclease III
LA331_11395	COG3293	Transposase
LA331_11410	COG0189	ligase activity
LA331_11425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LA331_11435	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LA331_11445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LA331_11475	COG2119	membrane
LA331_11480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LA331_11480	COG0426	domain, Protein
LA331_11505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LA331_11530	COG1902	pentaerythritol trinitrate reductase activity
LA331_11535	COG1519	Transferase
LA331_11540	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LA331_11545	COG0668	transmembrane transport
LA331_11555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LA331_11570	COG0307	riboflavin synthase, alpha
LA331_11580	COG0431	NADPH-dependent FMN reductase
LA331_11595	COG2198	Histidine kinase
LA331_11595	COG2205	protein histidine kinase activity
LA331_11595	COG0784	Response regulator, receiver
LA331_11600	COG3162	membrane
LA331_11605	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LA331_11615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LA331_11625	COG3706	GGDEF domain
LA331_11630	COG0537	adenosine 5'-monophosphoramidase activity
LA331_11640	COG0351	phosphomethylpyrimidine kinase
LA331_11640	COG0352	thiamine-phosphate diphosphorylase activity
LA331_11640	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LA331_11650	COG2814	Major facilitator Superfamily
LA331_11655	COG0629	single-stranded DNA binding
LA331_11710	COG3158	transport of potassium into the cell
LA331_11745	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LA331_11775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LA331_11850	COG1024	Enoyl-CoA hydratase
LA331_11850	COG1250	3-hydroxyacyl-CoA dehydrogenase
LA331_11880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LA331_11895	COG3275	phosphorelay sensor kinase activity
LA331_11905	COG0181	hydroxymethylbilane synthase activity
LA331_11925	COG0824	Thioesterase
LA331_11955	COG0546	phosphoglycolate phosphatase activity
LA331_12015	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LA331_12030	COG0085	RNA polymerase activity
LA331_12035	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LA331_12055	COG2056	Na+-H+ antiporter family
LA331_12060	COG3047	cAMP biosynthetic process
LA331_12070	COG0326	Molecular chaperone. Has ATPase activity
LA331_12105	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LA331_12110	COG0427	acetyl-CoA hydrolase
LA331_12145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LA331_12155	COG2226	methyltransferase
LA331_12175	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LA331_12180	COG1074	ATP-dependent DNA helicase activity
LA331_12185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LA331_12190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LA331_12200	COG2841	Protein conserved in bacteria
LA331_12205	COG0789	Transcriptional regulator
LA331_12225	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LA331_12235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LA331_12260	COG4535	Mg2 and Co2 transporter CorC
LA331_12265	COG0425	Belongs to the sulfur carrier protein TusA family
LA331_12285	COG0644	oxidoreductase
LA331_12285	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LA331_12295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LA331_12310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LA331_12320	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LA331_12330	COG0644	oxidoreductase
LA331_12340	COG2226	methyltransferase
LA331_12355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LA331_12380	COG0751	glycine-tRNA ligase activity
LA331_12385	COG0752	glycyl-tRNA synthetase alpha subunit
LA331_12395	COG0517	IMP dehydrogenase activity
LA331_12395	COG0617	tRNA 3'-terminal CCA addition
LA331_12395	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LA331_12400	COG0471	metal ion transport
LA331_12410	COG1983	PspC domain protein
LA331_12435	COG0318	PFAM AMP-dependent synthetase and ligase
LA331_12440	COG1530	ribonuclease E activity
LA331_12450	COG0546	phosphoglycolate phosphatase activity
LA331_12455	COG3971	2-oxopent-4-enoate hydratase activity
LA331_12460	COG4569	acetaldehyde dehydrogenase (acetylating) activity
LA331_12480	COG0583	DNA-binding transcription factor activity
LA331_12485	COG4638	Rieske (2fe-2S)
LA331_12500	COG1028	Short-chain dehydrogenase reductase Sdr
LA331_12505	COG3384	dioxygenase
LA331_12510	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA331_12550	COG0753	catalase activity
LA331_12600	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LA331_12615	COG0473	3-isopropylmalate dehydrogenase activity
LA331_12680	COG1560	Kdo2-lipid A biosynthetic process
LA331_12685	COG0488	(ABC) transporter
LA331_12690	COG2900	Belongs to the SlyX family
LA331_12730	COG1929	Belongs to the glycerate kinase type-1 family
LA331_12735	COG0210	DNA helicase
LA331_12740	COG0724	RNA recognition motif
LA331_12755	COG4651	solute:proton antiporter activity
LA331_12755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LA331_12780	COG0788	formyltetrahydrofolate deformylase activity
LA331_12815	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LA331_12850	COG0784	Response regulator, receiver
LA331_12850	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LA331_12855	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LA331_12860	COG4372	Transposase
LA331_12890	COG4974	Belongs to the 'phage' integrase family
LA331_12900	COG3040	lipid binding
LA331_12950	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LA331_12950	COG2813	Specifically methylates the guanine in position
LA331_12955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LA331_12960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LA331_12970	COG4774	siderophore transport
LA331_12980	COG0740	serine-type endopeptidase activity
LA331_12995	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LA331_12995	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LA331_13005	COG0280	phosphate acetyltransferase
LA331_13005	COG0857	belongs to the CobB CobQ family
LA331_13010	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LA331_13035	COG0793	Belongs to the peptidase S41A family
LA331_13080	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LA331_13095	COG0084	hydrolase, TatD family'
LA331_13125	COG1162	GTPase activity
LA331_13130	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LA331_13140	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LA331_13150	COG1538	Outer membrane efflux protein
LA331_13155	COG0577	efflux transmembrane transporter activity
LA331_13155	COG1136	(ABC) transporter
LA331_13160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA331_13190	COG0028	Belongs to the TPP enzyme family
LA331_13210	COG2975	iron-sulfur cluster assembly
LA331_13230	COG1426	Protein conserved in bacteria
LA331_13240	COG0124	histidyl-tRNA synthetase
LA331_13280	COG3956	TIGRFAM MazG family protein
LA331_13285	COG1596	polysaccharide export
LA331_13285	COG1555	photosystem II stabilization
LA331_13290	COG0617	tRNA 3'-terminal CCA addition
LA331_13295	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LA331_13310	COG1660	Displays ATPase and GTPase activities
LA331_13325	COG2205	protein histidine kinase activity
LA331_13330	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LA331_13360	COG0438	transferase activity, transferring glycosyl groups
LA331_13375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LA331_13415	COG1960	acyl-CoA dehydrogenase activity
LA331_13420	COG1960	acyl-CoA dehydrogenase activity
LA331_13430	COG2205	protein histidine kinase activity
LA331_13435	COG0745	RESPONSE REGULATOR receiver
LA331_13445	COG1113	amino acid transport
LA331_13460	COG2315	Protein conserved in bacteria
LA331_13465	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LA331_13480	COG2096	Adenosyltransferase
LA331_13485	COG4206	TonB-dependent receptor
LA331_13530	COG0285	dihydrofolate synthase activity
LA331_13545	COG0450	alkyl hydroperoxide reductase
LA331_13560	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LA331_13565	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LA331_13650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LA331_13655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LA331_13705	COG0494	nUDIX hydrolase
LA331_13715	COG1214	PFAM Peptidase M22, glycoprotease
LA331_13720	COG1968	undecaprenyl-diphosphatase activity
LA331_13735	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LA331_13755	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LA331_13765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LA331_13780	COG2814	Major facilitator Superfamily
LA331_13785	COG1012	belongs to the aldehyde dehydrogenase family
LA331_13785	COG2030	dehydratase
LA331_13790	COG3396	Phenylacetate-CoA oxygenase
LA331_13795	COG3460	Phenylacetate-CoA oxygenase
LA331_13800	COG3396	Phenylacetate-CoA oxygenase
LA331_13805	COG2151	metal-sulfur cluster biosynthetic enzyme
LA331_13810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LA331_13815	COG1024	Enoyl-CoA hydratase
LA331_13820	COG0183	Belongs to the thiolase family
LA331_13825	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
LA331_13830	COG3327	negative regulation of DNA-templated transcription, initiation
LA331_13840	COG2226	methyltransferase
LA331_13850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LA331_13860	COG3545	Serine hydrolase
LA331_13875	COG0730	response to heat
LA331_13885	COG1196	nuclear chromosome segregation
LA331_13895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LA331_13900	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LA331_13905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LA331_13910	COG2193	ferroxidase activity
LA331_13930	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LA331_13940	COG4166	transmembrane transport
LA331_13950	COG0339	signal peptide processing
LA331_13980	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LA331_13985	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LA331_14000	COG0009	L-threonylcarbamoyladenylate synthase
LA331_14005	COG3101	peptidyl-lysine hydroxylation
LA331_14010	COG1399	metal-binding, possibly nucleic acid-binding protein
LA331_14015	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LA331_14025	COG1028	Short-chain dehydrogenase reductase Sdr
LA331_14030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LA331_14035	COG1652	LysM domain
LA331_14055	COG0251	oxidation-reduction process
LA331_14060	COG1113	amino acid transport
LA331_14065	COG1981	membrane
LA331_14080	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LA331_14105	COG0456	acetyltransferase
LA331_14115	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LA331_14120	COG0492	ferredoxin-NADP+ reductase activity
LA331_14125	COG1674	ftsk spoiiie
LA331_14125	COG0531	amino acid
LA331_14140	COG2894	cell division
LA331_14155	COG0204	Acyl-transferase
LA331_14160	COG2885	chlorophyll binding
LA331_14170	COG0756	dUTP diphosphatase activity
LA331_14190	COG0121	glutamine amidotransferase
LA331_14205	COG2914	Belongs to the UPF0125 (RnfH) family
LA331_14210	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA331_14215	COG0735	belongs to the Fur family
LA331_14245	COG0420	3'-5' exonuclease activity
LA331_14255	COG1090	epimerase
LA331_14260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LA331_14270	COG2050	protein possibly involved in aromatic compounds catabolism
LA331_14275	COG1566	PFAM secretion protein HlyD family protein
LA331_14280	COG2814	Major facilitator Superfamily
LA331_14285	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LA331_14300	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LA331_14300	COG0131	Imidazoleglycerol-phosphate dehydratase
LA331_14340	COG3293	Transposase
LA331_14380	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LA331_14400	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LA331_14410	COG0402	S-adenosylhomocysteine deaminase activity
LA331_14420	COG0277	FAD linked oxidase domain protein
LA331_14430	COG0583	DNA-binding transcription factor activity
LA331_14445	COG0657	acetylesterase activity
LA331_14450	COG4638	Rieske (2fe-2S)
LA331_14455	COG1012	belongs to the aldehyde dehydrogenase family
LA331_14475	COG0582	viral genome integration into host DNA
LA331_14485	COG2223	nitrite transmembrane transporter activity
LA331_14490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LA331_14495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LA331_14500	COG0243	molybdopterin cofactor binding
LA331_14510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LA331_14520	COG0314	molybdopterin synthase activity
LA331_14525	COG0521	Mo-molybdopterin cofactor biosynthetic process
LA331_14525	COG0315	cyclic pyranopterin monophosphate synthase activity
LA331_14530	COG0303	'Molybdopterin
LA331_14535	COG0725	ABC transporter, periplasmic molybdate-binding protein
LA331_14540	COG4149	molybdate abc transporter
LA331_14545	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LA331_14555	COG3706	GGDEF domain
LA331_14570	COG0783	Belongs to the Dps family
LA331_14595	COG0500	methyltransferase
LA331_14605	COG2223	nitrite transmembrane transporter activity
LA331_14610	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LA331_14625	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
LA331_14640	COG3590	peptidase
LA331_14645	COG3590	peptidase
LA331_14655	COG0697	spore germination
LA331_14670	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LA331_14680	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LA331_14685	COG1077	Cell shape determining protein MreB Mrl
LA331_14690	COG1792	Involved in formation and maintenance of cell shape
LA331_14695	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LA331_14700	COG0424	maF-like protein
LA331_14715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LA331_14725	COG0560	Phosphoserine phosphatase
LA331_14745	COG1113	amino acid transport
LA331_14750	COG2828	Protein conserved in bacteria
LA331_14755	COG0142	geranyltranstransferase activity
LA331_14760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LA331_14775	COG1752	Esterase of the alpha-beta hydrolase superfamily
LA331_14795	COG0546	phosphoglycolate phosphatase activity
LA331_14800	COG2323	membrane
LA331_14815	COG2852	Protein conserved in bacteria
LA331_14825	COG0525	valine-tRNA ligase activity
LA331_14835	COG1028	Short-chain dehydrogenase reductase Sdr
LA331_14840	COG2066	Belongs to the glutaminase family
LA331_14845	COG2376	Dihydroxyacetone kinase
LA331_14850	COG2852	Protein conserved in bacteria
LA331_14860	COG2826	transposase and inactivated derivatives, IS30 family
LA331_14870	COG0306	phosphate transporter
LA331_14880	COG4607	ABC-type enterochelin transport system periplasmic component
LA331_14895	COG4771	TonB-dependent receptor
LA331_14920	COG4181	ATPase activity
LA331_14925	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LA331_14935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LA331_14950	COG0583	DNA-binding transcription factor activity
LA331_14960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LA331_14965	COG1773	rubredoxin
LA331_14970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LA331_15000	COG2354	Protein conserved in bacteria
LA331_15005	COG2321	neutral zinc metallopeptidase
LA331_15025	COG0589	response to stress
LA331_15030	COG3293	Transposase
LA331_15045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LA331_15045	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LA331_15065	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LA331_15070	COG1053	succinate dehydrogenase
LA331_15075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LA331_15090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA331_15100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LA331_15105	COG2268	Band 7 protein
LA331_15150	COG3118	belongs to the thioredoxin family
LA331_15160	COG4221	oxidoreductase activity
LA331_15160	COG3321	synthase
LA331_15160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LA331_15160	COG0604	alcohol dehydrogenase
LA331_15185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LA331_15200	COG0477	Major facilitator Superfamily
LA331_15210	COG1597	lipid kinase activity
LA331_15225	COG0459	protein refolding
LA331_15230	COG2963	transposase activity
LA331_15240	COG4372	Transposase
LA331_15290	COG0742	ribosomal rna small subunit methyltransferase
LA331_15295	COG0768	penicillin binding
LA331_15320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LA331_15325	COG2878	Part of a membrane complex involved in electron transport
LA331_15330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LA331_15340	COG3384	dioxygenase
LA331_15345	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LA331_15350	COG2234	aminopeptidase activity
LA331_15360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LA331_15385	COG0006	proline dipeptidase activity
LA331_15395	COG2826	transposase and inactivated derivatives, IS30 family
LA331_15405	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LA331_15410	COG2826	transposase and inactivated derivatives, IS30 family
LA331_15415	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LA331_15425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LA331_15430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LA331_15445	COG3107	peptidoglycan biosynthetic process
LA331_15460	COG0657	acetylesterase activity
LA331_15465	COG2816	NAD+ diphosphatase activity
LA331_15480	COG1388	LysM domain
LA331_15480	COG0741	lytic transglycosylase activity
LA331_15485	COG4166	transmembrane transport
LA331_15490	COG4174	ABC transporter (Permease)
LA331_15495	COG4239	(ABC) transporter, permease
LA331_15525	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LA331_15555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LA331_15560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LA331_15565	COG0730	response to heat
LA331_15570	COG0583	DNA-binding transcription factor activity
LA331_15580	COG2194	sulfuric ester hydrolase activity
LA331_15585	COG0745	RESPONSE REGULATOR receiver
LA331_15590	COG0642	Histidine kinase
LA331_15610	COG1120	ATPase activity
LA331_15615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LA331_15620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LA331_15630	COG1802	Transcriptional regulator
LA331_15635	COG1063	alcohol dehydrogenase
LA331_15645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA331_15650	COG0508	dehydrogenase complex catalyzes the overall conversion of
LA331_15655	COG0022	dehydrogenase e1 component
LA331_15660	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LA331_15665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LA331_15680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LA331_15680	COG0475	glutathione-regulated potassium exporter activity
LA331_15725	COG1373	ATPase (AAA superfamily
LA331_15825	COG0604	alcohol dehydrogenase
LA331_15830	COG1309	transcriptional regulator
LA331_15835	COG0583	DNA-binding transcription factor activity
LA331_15840	COG1380	Effector of murein hydrolase LrgA
LA331_15845	COG1346	cytolysis
LA331_15880	COG1192	Involved in chromosome partitioning
LA331_15935	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LA331_15940	COG4774	siderophore transport
LA331_15960	COG1454	alcohol dehydrogenase
LA331_15985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA331_16005	COG2226	methyltransferase
LA331_16005	COG2267	carboxylic ester hydrolase activity
LA331_16050	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LA331_16055	COG3293	Transposase
LA331_16070	COG1215	transferase activity, transferring glycosyl groups
LA331_16100	COG4106	trans-aconitate 2-methyltransferase activity
LA331_16155	COG4221	oxidoreductase activity
LA331_16160	COG0583	DNA-binding transcription factor activity
LA331_16165	COG1064	alcohol dehydrogenase
LA331_16170	COG3321	synthase
LA331_16170	COG0604	alcohol dehydrogenase
LA331_16185	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LA331_16200	COG1979	alcohol dehydrogenase
LA331_16220	COG1309	transcriptional regulator
LA331_16225	COG2130	NADP-dependent
LA331_16250	COG0579	oxidoreductase
LA331_16275	COG1028	Short-chain dehydrogenase reductase Sdr
LA331_16295	COG2223	nitrite transmembrane transporter activity
LA331_16355	COG1373	ATPase (AAA superfamily
LA331_16440	COG2072	flavoprotein involved in K transport
LA331_16445	COG0431	NADPH-dependent FMN reductase
LA331_16450	COG0798	PFAM Bile acid sodium symporter
LA331_16460	COG0640	Transcriptional regulator
LA331_16470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LA331_16505	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
LA331_16535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA331_16580	COG2217	Heavy metal translocating P-type atpase
LA331_16585	COG3174	membrane
LA331_16590	COG2205	protein histidine kinase activity
LA331_16605	COG2132	Multicopper oxidase
LA331_16630	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA331_16695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LA331_16715	COG2369	cell adhesion
LA331_16770	COG1063	alcohol dehydrogenase
LA331_16860	COG0589	response to stress