locus-tag	class	description
HWI77_00010	COG0592	DNA-directed DNA polymerase activity
HWI77_00020	COG0187	DNA topoisomerase II activity
HWI77_00030	COG0586	Pfam SNARE associated Golgi protein
HWI77_00035	COG0488	(ABC) transporter
HWI77_00070	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HWI77_00075	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HWI77_00160	COG0583	DNA-binding transcription factor activity
HWI77_00165	COG1028	Short-chain dehydrogenase reductase Sdr
HWI77_00170	COG2233	PERMEase
HWI77_00180	COG1309	transcriptional regulator
HWI77_00185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWI77_00215	COG2814	Major facilitator Superfamily
HWI77_00220	COG0656	L-ascorbic acid biosynthetic process
HWI77_00225	COG0583	DNA-binding transcription factor activity
HWI77_00235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWI77_00240	COG1064	alcohol dehydrogenase
HWI77_00245	COG2818	Glycosylase
HWI77_00260	COG1194	a g-specific adenine glycosylase
HWI77_00270	COG5487	UPF0391 membrane protein
HWI77_00275	COG2983	Belongs to the UPF0260 family
HWI77_00280	COG2133	pyrroloquinoline quinone binding
HWI77_00290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HWI77_00300	COG0402	S-adenosylhomocysteine deaminase activity
HWI77_00305	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HWI77_00315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWI77_00320	COG1335	isochorismatase
HWI77_00335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HWI77_00345	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HWI77_00350	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HWI77_00355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HWI77_00375	COG0560	Phosphoserine phosphatase
HWI77_00375	COG3830	Belongs to the UPF0237 family
HWI77_00420	COG0583	DNA-binding transcription factor activity
HWI77_00455	COG0534	Mate efflux family protein
HWI77_00460	COG0436	Aminotransferase
HWI77_00470	COG2733	membrane
HWI77_00500	COG3150	esterase
HWI77_00575	COG3706	GGDEF domain
HWI77_00590	COG1393	Belongs to the ArsC family
HWI77_00595	COG0708	Exodeoxyribonuclease III
HWI77_00635	COG0386	Belongs to the glutathione peroxidase family
HWI77_00640	COG0189	ligase activity
HWI77_00660	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HWI77_00670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HWI77_00705	COG2119	membrane
HWI77_00710	COG4774	siderophore transport
HWI77_00715	COG0426	domain, Protein
HWI77_00715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWI77_00740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HWI77_00765	COG1902	pentaerythritol trinitrate reductase activity
HWI77_00770	COG1519	Transferase
HWI77_00775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HWI77_00780	COG0668	transmembrane transport
HWI77_00790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWI77_00795	COG1335	isochorismatase
HWI77_00800	COG1522	sequence-specific DNA binding
HWI77_00830	COG3706	GGDEF domain
HWI77_00860	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HWI77_00870	COG2814	Major facilitator Superfamily
HWI77_00885	COG1113	amino acid transport
HWI77_00895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HWI77_00900	COG1012	belongs to the aldehyde dehydrogenase family
HWI77_00910	COG1335	isochorismatase
HWI77_00920	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HWI77_00940	COG3152	Membrane
HWI77_01005	COG2329	Antibiotic biosynthesis monooxygenase
HWI77_01020	COG0659	secondary active sulfate transmembrane transporter activity
HWI77_01040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HWI77_01125	COG0583	DNA-binding transcription factor activity
HWI77_01135	COG0477	Major facilitator Superfamily
HWI77_01140	COG0789	Transcriptional regulator
HWI77_01145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWI77_01145	COG3320	Male sterility
HWI77_01160	COG4221	oxidoreductase activity
HWI77_01165	COG2873	o-acetylhomoserine
HWI77_01170	COG0488	(ABC) transporter
HWI77_01245	COG0833	amino acid
HWI77_01270	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HWI77_01290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HWI77_01295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HWI77_01305	COG2226	methyltransferase
HWI77_01355	COG0070	glutamate synthase
HWI77_01355	COG0067	glutamate synthase
HWI77_01355	COG0069	glutamate synthase activity
HWI77_01360	COG0493	'glutamate synthase
HWI77_01370	COG1704	LemA family
HWI77_01375	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HWI77_01400	COG4969	Belongs to the N-Me-Phe pilin family
HWI77_01410	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HWI77_01430	COG3307	-O-antigen
HWI77_01450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWI77_01460	COG0194	GDP metabolic process
HWI77_01470	COG4969	Belongs to the N-Me-Phe pilin family
HWI77_01505	COG0228	four-way junction DNA binding
HWI77_01510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HWI77_01520	COG0335	large ribosomal subunit rRNA binding
HWI77_01525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HWI77_01545	COG5006	permease, DMT superfamily
HWI77_01550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HWI77_01555	COG0277	FAD linked oxidase domain protein
HWI77_01575	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HWI77_01580	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWI77_01600	COG1289	transmembrane transporter activity
HWI77_01610	COG0628	permease
HWI77_01625	COG2226	methyltransferase
HWI77_01670	COG2072	flavoprotein involved in K transport
HWI77_01715	COG0471	metal ion transport
HWI77_01725	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HWI77_01725	COG0517	IMP dehydrogenase activity
HWI77_01725	COG0617	tRNA 3'-terminal CCA addition
HWI77_01730	COG1983	PspC domain protein
HWI77_01740	COG1960	acyl-CoA dehydrogenase activity
HWI77_01755	COG0406	alpha-ribazole phosphatase activity
HWI77_01760	COG0408	coproporphyrinogen oxidase activity
HWI77_01780	COG0513	Belongs to the DEAD box helicase family
HWI77_01785	COG1127	ABC transporter
HWI77_01790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HWI77_01795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HWI77_01800	COG2854	intermembrane phospholipid transfer
HWI77_01815	COG0598	Magnesium transport protein CorA
HWI77_01825	COG0494	nUDIX hydrolase
HWI77_01830	COG1040	competence protein
HWI77_01835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HWI77_01850	COG2937	Belongs to the GPAT DAPAT family
HWI77_01855	COG1946	Acyl-CoA thioesterase
HWI77_01865	COG1301	dicarboxylic acid transport
HWI77_01880	COG1959	2 iron, 2 sulfur cluster binding
HWI77_01900	COG0433	COG0433 Predicted ATPase
HWI77_01905	COG0626	cystathionine gamma-synthase activity
HWI77_01920	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HWI77_01940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HWI77_02005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HWI77_02070	COG1960	acyl-CoA dehydrogenase activity
HWI77_02075	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HWI77_02105	COG0697	spore germination
HWI77_02130	COG0339	signal peptide processing
HWI77_02140	COG0557	exoribonuclease II activity
HWI77_02185	COG0179	Fumarylacetoacetate (FAA) hydrolase
HWI77_02205	COG1295	ribonuclease BN
HWI77_02265	COG2813	Specifically methylates the guanine in position
HWI77_02265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HWI77_02275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HWI77_02285	COG4774	siderophore transport
HWI77_02295	COG0740	serine-type endopeptidase activity
HWI77_02315	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HWI77_02315	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HWI77_02320	COG1917	Cupin 2, conserved barrel domain protein
HWI77_02320	COG2207	Transcriptional regulator
HWI77_02325	COG0697	spore germination
HWI77_02330	COG0857	belongs to the CobB CobQ family
HWI77_02330	COG0280	phosphate acetyltransferase
HWI77_02335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HWI77_02345	COG2267	carboxylic ester hydrolase activity
HWI77_02360	COG0793	Belongs to the peptidase S41A family
HWI77_02385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HWI77_02400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWI77_02405	COG1408	metallophosphoesterase
HWI77_02410	COG2885	chlorophyll binding
HWI77_02415	COG2199	diguanylate cyclase activity
HWI77_02465	COG1960	acyl-CoA dehydrogenase activity
HWI77_02490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWI77_02495	COG1309	transcriptional regulator
HWI77_02510	COG1028	Short-chain dehydrogenase reductase Sdr
HWI77_02515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWI77_02520	COG1960	acyl-CoA dehydrogenase activity
HWI77_02575	COG2969	positive regulation of protein catabolic process
HWI77_02580	COG0625	glutathione transferase activity
HWI77_02590	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HWI77_02605	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HWI77_02610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HWI77_02615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HWI77_02630	COG2975	iron-sulfur cluster assembly
HWI77_02650	COG1426	Protein conserved in bacteria
HWI77_02670	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HWI77_02690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWI77_02695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWI77_02705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HWI77_02720	COG2986	histidine ammonia-lyase
HWI77_02760	COG1028	Short-chain dehydrogenase reductase Sdr
HWI77_02765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWI77_02785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HWI77_02795	COG1862	Preprotein translocase
HWI77_02820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HWI77_02845	COG2205	protein histidine kinase activity
HWI77_02850	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HWI77_02925	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HWI77_02965	COG1960	acyl-CoA dehydrogenase activity
HWI77_02970	COG1960	acyl-CoA dehydrogenase activity
HWI77_02980	COG2205	protein histidine kinase activity
HWI77_02985	COG0745	RESPONSE REGULATOR receiver
HWI77_02995	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HWI77_03015	COG2096	Adenosyltransferase
HWI77_03020	COG4206	TonB-dependent receptor
HWI77_03075	COG0285	dihydrofolate synthase activity
HWI77_03095	COG0450	alkyl hydroperoxide reductase
HWI77_03115	COG0477	Major facilitator Superfamily
HWI77_03120	COG1272	protein, Hemolysin III
HWI77_03155	COG0183	Belongs to the thiolase family
HWI77_03175	COG2207	Transcriptional regulator
HWI77_03180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HWI77_03195	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWI77_03215	COG0183	Belongs to the thiolase family
HWI77_03225	COG2885	chlorophyll binding
HWI77_03225	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HWI77_03235	COG1690	Belongs to the RtcB family
HWI77_03240	COG0833	amino acid
HWI77_03250	COG2233	PERMEase
HWI77_03255	COG1217	gtp-binding protein TYPA
HWI77_03275	COG4772	TonB-dependent receptor
HWI77_03285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWI77_03290	COG0354	folic acid binding
HWI77_03305	COG3189	MarR family transcriptional regulator
HWI77_03310	COG2824	Alkylphosphonate utilization operon protein PhnA
HWI77_03315	COG3422	double-strand break repair
HWI77_03345	COG0840	transmembrane signaling receptor activity
HWI77_03350	COG0643	Histidine kinase
HWI77_03350	COG2198	Histidine kinase
HWI77_03350	COG2198	Histidine kinase
HWI77_03350	COG0643	Histidine kinase
HWI77_03365	COG5510	response to toxic substance
HWI77_03375	COG2832	Protein of unknown function (DUF454)
HWI77_03435	COG1289	transmembrane transporter activity
HWI77_03440	COG2814	Major facilitator Superfamily
HWI77_03455	COG0786	glutamate:sodium symporter activity
HWI77_03460	COG1115	amino acid carrier protein
HWI77_03465	COG1752	Esterase of the alpha-beta hydrolase superfamily
HWI77_03470	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HWI77_03535	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HWI77_03545	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HWI77_03550	COG1077	Cell shape determining protein MreB Mrl
HWI77_03555	COG1792	Involved in formation and maintenance of cell shape
HWI77_03560	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HWI77_03565	COG0424	maF-like protein
HWI77_03570	COG1530	ribonuclease E activity
HWI77_03580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWI77_03590	COG0560	Phosphoserine phosphatase
HWI77_03610	COG2851	Citrate transporter
HWI77_03620	COG0671	phosphoesterase, PA-phosphatase related
HWI77_03680	COG1113	amino acid transport
HWI77_03690	COG0142	geranyltranstransferase activity
HWI77_03695	COG2814	Major facilitator Superfamily
HWI77_03710	COG1752	Esterase of the alpha-beta hydrolase superfamily
HWI77_03730	COG2194	sulfuric ester hydrolase activity
HWI77_03740	COG0642	Histidine kinase
HWI77_03755	COG0004	ammonium transporteR
HWI77_03775	COG0525	valine-tRNA ligase activity
HWI77_03790	COG1028	Short-chain dehydrogenase reductase Sdr
HWI77_03800	COG0393	Putative heavy-metal-binding
HWI77_03805	COG0393	Putative heavy-metal-binding
HWI77_03810	COG1538	Outer membrane efflux protein
HWI77_03815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWI77_03820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWI77_03825	COG0671	phosphoesterase, PA-phosphatase related
HWI77_03855	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HWI77_03860	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HWI77_03875	COG1648	precorrin-2 dehydrogenase activity
HWI77_03875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HWI77_03880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HWI77_03890	COG1733	regulation of RNA biosynthetic process
HWI77_03900	COG0531	amino acid
HWI77_03915	COG0321	lipoyl(octanoyl) transferase activity
HWI77_03925	COG2921	Belongs to the UPF0250 family
HWI77_03945	COG1280	lysine exporter protein (LysE YggA)
HWI77_03950	COG0583	DNA-binding transcription factor activity
HWI77_03955	COG0500	methyltransferase
HWI77_03960	COG0586	Pfam SNARE associated Golgi protein
HWI77_03965	COG1054	Belongs to the UPF0176 family
HWI77_03990	COG2009	succinate dehydrogenase
HWI77_03995	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HWI77_04000	COG1053	succinate dehydrogenase
HWI77_04005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HWI77_04020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWI77_04040	COG2268	Band 7 protein
HWI77_04045	COG1585	Membrane protein implicated in regulation of membrane protease activity
HWI77_04055	COG2354	Protein conserved in bacteria
HWI77_04060	COG2321	neutral zinc metallopeptidase
HWI77_04100	COG0589	response to stress
HWI77_04110	COG0110	maltose O-acetyltransferase activity
HWI77_04125	COG0505	Belongs to the CarA family
HWI77_04150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HWI77_04155	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HWI77_04160	COG2304	oxidoreductase activity
HWI77_04190	COG0584	glycerophosphoryl diester phosphodiesterase
HWI77_04195	COG2194	sulfuric ester hydrolase activity
HWI77_04215	COG0501	Belongs to the peptidase M48B family
HWI77_04220	COG0741	lytic transglycosylase activity
HWI77_04235	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HWI77_04240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HWI77_04275	COG3209	COG3209 Rhs family protein
HWI77_04310	COG4964	Belongs to the GSP D family
HWI77_04350	COG1607	acyl-coa hydrolase
HWI77_04360	COG0523	cobalamin synthesis protein
HWI77_04365	COG4681	YaeQ
HWI77_04380	COG0726	polysaccharide deacetylase
HWI77_04380	COG1649	PFAM Uncharacterised BCR, COG1649
HWI77_04385	COG1215	transferase activity, transferring glycosyl groups
HWI77_04415	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HWI77_04425	COG2388	GCN5-related N-acetyl-transferase
HWI77_04435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HWI77_04450	COG4773	Receptor
HWI77_04455	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HWI77_04460	COG1597	lipid kinase activity
HWI77_04465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HWI77_04540	COG1979	alcohol dehydrogenase
HWI77_04555	COG1012	belongs to the aldehyde dehydrogenase family
HWI77_04560	COG1902	pentaerythritol trinitrate reductase activity
HWI77_04570	COG1309	transcriptional regulator
HWI77_04575	COG2130	NADP-dependent
HWI77_04590	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HWI77_04595	COG0732	type I restriction modification DNA specificity domain
HWI77_04610	COG0582	viral genome integration into host DNA
HWI77_04655	COG4771	TonB-dependent receptor
HWI77_04680	COG4181	ATPase activity
HWI77_04685	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HWI77_04690	COG0457	Tetratricopeptide repeat
HWI77_04690	COG0705	Rhomboid family
HWI77_04710	COG1294	oxidase, subunit
HWI77_04715	COG1271	oxidase subunit
HWI77_04745	COG1215	transferase activity, transferring glycosyl groups
HWI77_04770	COG1252	NADH dehydrogenase
HWI77_04775	COG1686	Belongs to the peptidase S11 family
HWI77_04805	COG1187	pseudouridine synthase activity
HWI77_04825	COG0612	Peptidase, M16
HWI77_04860	COG0725	ABC transporter, periplasmic molybdate-binding protein
HWI77_04865	COG4149	molybdate abc transporter
HWI77_04870	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HWI77_04890	COG4521	taurine ABC transporter
HWI77_04895	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HWI77_04900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWI77_04905	COG2175	clavaminate synthase activity
HWI77_04940	COG0589	response to stress
HWI77_04960	COG0242	peptide deformylase activity
HWI77_04965	COG2852	Protein conserved in bacteria
HWI77_04980	COG0306	phosphate transporter
HWI77_04995	COG1115	amino acid carrier protein
HWI77_05005	COG1113	amino acid transport
HWI77_05015	COG0019	diaminopimelate decarboxylase activity
HWI77_05020	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HWI77_05030	COG1280	lysine exporter protein (LysE YggA)
HWI77_05035	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HWI77_05075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWI77_05100	COG1671	Belongs to the UPF0178 family
HWI77_05115	COG4591	ABC-type transport system involved in lipoprotein release permease component
HWI77_05120	COG1136	(ABC) transporter
HWI77_05125	COG2333	competence protein COMEC
HWI77_05125	COG0658	competence protein
HWI77_05135	COG0616	signal peptide processing
HWI77_05135	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HWI77_05145	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HWI77_05155	COG0628	permease
HWI77_05190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HWI77_05210	COG0823	Involved in the tonB-independent uptake of proteins
HWI77_05230	COG0824	Thioesterase
HWI77_05240	COG2255	four-way junction helicase activity
HWI77_05260	COG0047	phosphoribosylformylglycinamidine synthase activity
HWI77_05260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HWI77_05280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HWI77_05280	COG3323	Protein of unknown function (DUF1653)
HWI77_05285	COG0778	Nitroreductase
HWI77_05290	COG1024	Enoyl-CoA hydratase
HWI77_05295	COG1051	belongs to the nudix hydrolase family
HWI77_05295	COG1056	cytidyltransferase-related domain
HWI77_05300	COG0583	DNA-binding transcription factor activity
HWI77_05305	COG0625	glutathione transferase activity
HWI77_05310	COG1942	4-Oxalocrotonate Tautomerase
HWI77_05325	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HWI77_05340	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HWI77_05345	COG0602	queuosine metabolic process
HWI77_05360	COG0583	DNA-binding transcription factor activity
HWI77_05365	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HWI77_05370	COG4208	sulfate ABC transporter
HWI77_05375	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HWI77_05385	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HWI77_05390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWI77_05395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HWI77_05410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWI77_05420	COG0481	GTPase activity
HWI77_05435	COG0571	ribonuclease III activity
HWI77_05440	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HWI77_05455	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HWI77_05480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HWI77_05485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HWI77_05490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWI77_05500	COG2223	nitrite transmembrane transporter activity
HWI77_05510	COG0024	Methionine aminopeptidase
HWI77_05515	COG0052	Belongs to the universal ribosomal protein uS2 family
HWI77_05530	COG0280	phosphate acetyltransferase
HWI77_05530	COG0281	malic enzyme
HWI77_05540	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HWI77_05545	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HWI77_05550	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HWI77_05575	COG2011	ABC-type metal ion transport system permease component
HWI77_05580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HWI77_05585	COG1464	Belongs to the NlpA lipoprotein family
HWI77_05595	COG0138	bifunctional purine biosynthesis protein purh
HWI77_05600	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HWI77_05645	COG2252	PERMEase
HWI77_05650	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HWI77_05655	COG3038	cytochrome b561
HWI77_05670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HWI77_05680	COG0527	aspartate kinase activity
HWI77_05815	COG5410	chromosome segregation
HWI77_05820	COG3567	Phage-associated protein, HI1409 family
HWI77_05835	COG3566	protein conserved in bacteria
HWI77_05950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HWI77_06025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HWI77_06040	COG2308	Evidence 4 Homologs of previously reported genes of
HWI77_06050	COG1305	Transglutaminase-like
HWI77_06100	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HWI77_06105	COG1845	cytochrome c oxidase, subunit III
HWI77_06110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWI77_06140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWI77_06170	COG0802	atpase or kinase
HWI77_06175	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HWI77_06185	COG1923	regulation of RNA biosynthetic process
HWI77_06190	COG0697	spore germination
HWI77_06195	COG0778	Nitroreductase
HWI77_06210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HWI77_06215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HWI77_06215	COG0519	Catalyzes the synthesis of GMP from XMP
HWI77_06220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWI77_06225	COG4302	ethanolamine ammonia-lyase activity
HWI77_06230	COG4303	Ethanolamine ammonia lyase large subunit
HWI77_06235	COG0531	amino acid
HWI77_06245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HWI77_06295	COG1714	RDD family
HWI77_06300	COG0475	glutathione-regulated potassium exporter activity
HWI77_06300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWI77_06305	COG3135	benzoate transporter
HWI77_06315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HWI77_06330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HWI77_06360	COG0316	Belongs to the HesB IscA family
HWI77_06365	COG0822	iron-sulfur transferase activity
HWI77_06395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWI77_06410	COG2137	regulation of response to DNA damage stimulus
HWI77_06415	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HWI77_06420	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HWI77_06425	COG1011	Hydrolase
HWI77_06430	COG1218	3'(2'),5'-bisphosphate nucleotidase
HWI77_06445	COG0268	Binds directly to 16S ribosomal RNA
HWI77_06450	COG0702	epimerase
HWI77_06455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HWI77_06475	COG0183	Belongs to the thiolase family
HWI77_06485	COG2030	dehydratase
HWI77_06490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWI77_06510	COG0424	maF-like protein
HWI77_06535	COG0778	Nitroreductase
HWI77_06605	COG5295	Hep Hag repeat protein
HWI77_06625	COG5295	Hep Hag repeat protein
HWI77_06725	COG0436	Aminotransferase
HWI77_06735	COG0386	Belongs to the glutathione peroxidase family
HWI77_06755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWI77_06785	COG1942	4-Oxalocrotonate Tautomerase
HWI77_06795	COG1253	flavin adenine dinucleotide binding
HWI77_06800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWI77_06815	COG0012	GTP binding
HWI77_06820	COG2011	ABC-type metal ion transport system permease component
HWI77_06825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HWI77_06830	COG1464	Belongs to the NlpA lipoprotein family
HWI77_06995	COG0753	catalase activity
HWI77_07020	COG3539	Fimbrial protein
HWI77_07045	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HWI77_07045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HWI77_07055	COG0583	DNA-binding transcription factor activity
HWI77_07065	COG1278	Cold shock
HWI77_07100	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HWI77_07115	COG2353	YceI-like domain
HWI77_07125	COG3811	Belongs to the UPF0386 family
HWI77_07130	COG0590	tRNA wobble adenosine to inosine editing
HWI77_07140	COG3698	Phosphodiester glycosidase
HWI77_07150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HWI77_07155	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HWI77_07165	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HWI77_07165	COG0506	proline dehydrogenase activity
HWI77_07165	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HWI77_07175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWI77_07180	COG1027	Aspartate ammonia-lyase
HWI77_07200	COG1132	(ABC) transporter
HWI77_07235	COG0753	catalase activity
HWI77_07275	COG0640	Transcriptional regulator
HWI77_07295	COG2850	peptidyl-arginine hydroxylation
HWI77_07305	COG0824	Thioesterase
HWI77_07310	COG1454	alcohol dehydrogenase
HWI77_07315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWI77_07340	COG0069	glutamate synthase activity
HWI77_07380	COG2814	Major facilitator Superfamily
HWI77_07395	COG0439	Biotin carboxylase
HWI77_07410	COG1116	anion transmembrane transporter activity
HWI77_07410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWI77_07425	COG2146	nitrite reductase [NAD(P)H] activity
HWI77_07425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWI77_07430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWI77_07435	COG0243	molybdopterin cofactor binding
HWI77_07455	COG0243	molybdopterin cofactor binding
HWI77_07460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HWI77_07475	COG0521	Mo-molybdopterin cofactor biosynthetic process
HWI77_07475	COG0315	cyclic pyranopterin monophosphate synthase activity
HWI77_07480	COG0303	'Molybdopterin
HWI77_07490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWI77_07495	COG0697	spore germination
HWI77_07515	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HWI77_07520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HWI77_07565	COG2204	response regulator
HWI77_07570	COG3852	Histidine kinase
HWI77_07580	COG0528	UMP kinase activity
HWI77_07585	COG0233	cytoplasmic translational termination
HWI77_07590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HWI77_07595	COG0575	Belongs to the CDS family
HWI77_07610	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HWI77_07630	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HWI77_07635	COG2207	Transcriptional regulator
HWI77_07640	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWI77_07645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWI77_07650	COG1960	acyl-CoA dehydrogenase activity
HWI77_07655	COG1960	acyl-CoA dehydrogenase activity
HWI77_07735	COG0246	Mannitol dehydrogenase
HWI77_07750	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HWI77_07775	COG4772	TonB-dependent receptor
HWI77_07810	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HWI77_07835	COG0537	adenosine 5'-monophosphoramidase activity
HWI77_07870	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HWI77_07880	COG2226	methyltransferase
HWI77_07895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HWI77_07905	COG0133	tryptophan synthase activity
HWI77_07920	COG3706	GGDEF domain
HWI77_07930	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWI77_07945	COG1522	sequence-specific DNA binding
HWI77_08015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWI77_08045	COG1231	oxidoreductase activity
HWI77_08060	COG1309	transcriptional regulator
HWI77_08080	COG0583	DNA-binding transcription factor activity
HWI77_08095	COG0183	Belongs to the thiolase family
HWI77_08100	COG2814	Major facilitator Superfamily
HWI77_08115	COG0318	PFAM AMP-dependent synthetase and ligase
HWI77_08120	COG1309	transcriptional regulator
HWI77_08125	COG1960	acyl-CoA dehydrogenase activity
HWI77_08130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWI77_08135	COG1024	Enoyl-CoA hydratase
HWI77_08140	COG4770	biotin carboxylase activity
HWI77_08150	COG0583	DNA-binding transcription factor activity
HWI77_08170	COG4221	oxidoreductase activity
HWI77_08175	COG1944	ATP diphosphatase activity
HWI77_08180	COG3040	lipid binding
HWI77_08185	COG0833	amino acid
HWI77_08195	COG3724	N-succinylarginine dihydrolase activity
HWI77_08200	COG1012	belongs to the aldehyde dehydrogenase family
HWI77_08210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWI77_08215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWI77_08270	COG4829	muconolactone delta-isomerase
HWI77_08280	COG4638	Rieske (2fe-2S)
HWI77_08285	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HWI77_08290	COG0633	Ferredoxin
HWI77_08290	COG0543	2 iron, 2 sulfur cluster binding
HWI77_08295	COG1028	Short-chain dehydrogenase reductase Sdr
HWI77_08300	COG3135	benzoate transporter
HWI77_08305	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWI77_08310	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWI77_08315	COG0183	Belongs to the thiolase family
HWI77_08320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HWI77_08325	COG2814	Major facilitator Superfamily
HWI77_08335	COG1454	alcohol dehydrogenase
HWI77_08365	COG0604	alcohol dehydrogenase
HWI77_08365	COG3321	synthase
HWI77_08365	COG1028	Short-chain dehydrogenase reductase Sdr
HWI77_08370	COG2207	Transcriptional regulator
HWI77_08385	COG1802	Transcriptional regulator
HWI77_08405	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HWI77_08415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWI77_08455	COG4185	zeta toxin
HWI77_08475	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HWI77_08515	COG1902	pentaerythritol trinitrate reductase activity
HWI77_08515	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWI77_08525	COG2267	carboxylic ester hydrolase activity
HWI77_08530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HWI77_08535	COG0488	(ABC) transporter
HWI77_08545	COG0542	response to heat
HWI77_08550	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HWI77_08580	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HWI77_08585	COG0569	domain protein
HWI77_08590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HWI77_08635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWI77_08660	COG1294	oxidase, subunit
HWI77_08665	COG4890	Cyd operon protein YbgT
HWI77_08705	COG0552	protein localization to endoplasmic reticulum
HWI77_08730	COG0517	IMP dehydrogenase activity
HWI77_08735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWI77_08740	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HWI77_08780	COG1846	Transcriptional regulator
HWI77_08795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HWI77_08845	COG0776	regulation of translation
HWI77_08865	COG0590	tRNA wobble adenosine to inosine editing
HWI77_08910	COG0084	hydrolase, TatD family'
HWI77_08930	COG1663	tetraacyldisaccharide 4'-kinase activity
HWI77_08935	COG1132	(ABC) transporter
HWI77_08945	COG0811	peptide transport
HWI77_08950	COG1475	DNA binding
HWI77_08955	COG1192	Involved in chromosome partitioning
HWI77_08965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HWI77_08980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWI77_08990	COG0513	Belongs to the DEAD box helicase family
HWI77_09010	COG2363	Small membrane protein
HWI77_09055	COG4650	regulator
HWI77_09060	COG1234	tRNA 3'-trailer cleavage
HWI77_09070	COG1690	Belongs to the RtcB family
HWI77_09090	COG2195	Cleaves the N-terminal amino acid of tripeptides
HWI77_09095	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HWI77_09105	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HWI77_09125	COG1960	acyl-CoA dehydrogenase activity
HWI77_09130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HWI77_09140	COG3139	Protein of unknown function (DUF1315)
HWI77_09145	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HWI77_09150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWI77_09160	COG0494	nUDIX hydrolase
HWI77_09170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HWI77_09180	COG1720	tRNA m6t6A37 methyltransferase activity
HWI77_09215	COG0583	DNA-binding transcription factor activity
HWI77_09220	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HWI77_09230	COG2814	Major facilitator Superfamily
HWI77_09235	COG3647	Membrane
HWI77_09240	COG4607	ABC-type enterochelin transport system periplasmic component
HWI77_09245	COG4604	ABC transporter, ATP-binding protein
HWI77_09250	COG4605	iron ion homeostasis
HWI77_09255	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWI77_09260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWI77_09265	COG0471	metal ion transport
HWI77_09305	COG0729	surface antigen
HWI77_09335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HWI77_09355	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HWI77_09365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWI77_09405	COG0826	peptidase U32
HWI77_09410	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HWI77_09420	COG1116	anion transmembrane transporter activity
HWI77_09440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWI77_09445	COG0864	Transcriptional regulator
HWI77_09450	COG0439	Biotin carboxylase
HWI77_09495	COG1131	(ABC) transporter
HWI77_09500	COG0842	Transport permease protein
HWI77_09515	COG0772	Belongs to the SEDS family
HWI77_09520	COG2951	lytic endotransglycosylase activity
HWI77_09540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWI77_09545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HWI77_09560	COG1643	Atp-dependent helicase
HWI77_09580	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWI77_09585	COG2169	Transcriptional regulator
HWI77_09585	COG1917	Cupin 2, conserved barrel domain protein
HWI77_09600	COG3634	alkyl hydroperoxide reductase activity
HWI77_09620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HWI77_09670	COG1765	OsmC-like protein
HWI77_09680	COG0501	Belongs to the peptidase M48B family
HWI77_09685	COG4770	biotin carboxylase activity
HWI77_09695	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HWI77_09700	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HWI77_09705	COG2072	flavoprotein involved in K transport
HWI77_09725	COG1309	transcriptional regulator
HWI77_09735	COG2837	iron assimilation
HWI77_09740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HWI77_09745	COG0243	molybdopterin cofactor binding
HWI77_09780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWI77_09800	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWI77_09805	COG0010	Belongs to the arginase family
HWI77_09835	COG2188	Transcriptional regulator
HWI77_09845	COG0583	DNA-binding transcription factor activity
HWI77_09860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWI77_09865	COG1116	anion transmembrane transporter activity
HWI77_09870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWI77_09890	COG4266	Belongs to the allantoicase family
HWI77_09900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWI77_09905	COG1309	transcriptional regulator
HWI77_09925	COG1999	signal sequence binding
HWI77_09935	COG2233	PERMEase
HWI77_09940	COG2351	hydroxyisourate hydrolase activity
HWI77_09950	COG4993	Dehydrogenase
HWI77_09955	COG3659	wide pore channel activity
HWI77_09960	COG3420	alginic acid biosynthetic process
HWI77_09965	COG0710	3-dehydroquinate dehydratase activity
HWI77_09970	COG3485	protocatechuate 3,4-dioxygenase
HWI77_09975	COG3485	protocatechuate 3,4-dioxygenase
HWI77_09980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWI77_09985	COG2271	Major facilitator Superfamily
HWI77_09990	COG0596	Alpha beta hydrolase
HWI77_09995	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HWI77_10000	COG0183	Belongs to the thiolase family
HWI77_10005	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWI77_10010	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWI77_10015	COG1414	Transcriptional regulator
HWI77_10020	COG2985	domain, Protein
HWI77_10045	COG0745	RESPONSE REGULATOR receiver
HWI77_10050	COG0642	Histidine kinase
HWI77_10055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HWI77_10065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HWI77_10110	COG0523	cobalamin synthesis protein
HWI77_10120	COG1469	GTP cyclohydrolase I activity
HWI77_10125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HWI77_10140	COG3038	cytochrome b561
HWI77_10170	COG4104	PAAR repeat-containing protein
HWI77_10170	COG3209	COG3209 Rhs family protein
HWI77_10190	COG0582	viral genome integration into host DNA
HWI77_10200	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWI77_10245	COG2132	Multicopper oxidase
HWI77_10260	COG2205	protein histidine kinase activity
HWI77_10340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWI77_10340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWI77_10365	COG1111	helicase
HWI77_10365	COG1205	dead DEAH box helicase
HWI77_10375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HWI77_10400	COG1902	pentaerythritol trinitrate reductase activity
HWI77_10400	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWI77_10405	COG0697	spore germination
HWI77_10410	COG0583	DNA-binding transcription factor activity
HWI77_10425	COG1741	Belongs to the pirin family
HWI77_10435	COG4695	Portal protein
HWI77_10685	COG1063	alcohol dehydrogenase
HWI77_10690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWI77_10695	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWI77_10700	COG0022	dehydrogenase e1 component
HWI77_10705	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HWI77_10710	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HWI77_10735	COG0110	maltose O-acetyltransferase activity
HWI77_10740	COG0438	transferase activity, transferring glycosyl groups
HWI77_10855	COG0714	Associated with various cellular activities
HWI77_10860	COG2879	small protein
HWI77_10865	COG1966	Carbon starvation protein
HWI77_10870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HWI77_10945	COG1686	Belongs to the peptidase S11 family
HWI77_10950	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HWI77_10995	COG0028	Belongs to the TPP enzyme family
HWI77_11010	COG1028	Short-chain dehydrogenase reductase Sdr
HWI77_11025	COG2271	Major facilitator Superfamily
HWI77_11030	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWI77_11040	COG1028	Short-chain dehydrogenase reductase Sdr
HWI77_11060	COG1414	Transcriptional regulator
HWI77_11120	COG0697	spore germination
HWI77_11145	COG1610	YqeY-like protein
HWI77_11165	COG4783	chaperone-mediated protein folding
HWI77_11195	COG0583	DNA-binding transcription factor activity
HWI77_11240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWI77_11240	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HWI77_11250	COG1012	belongs to the aldehyde dehydrogenase family
HWI77_11265	COG0583	DNA-binding transcription factor activity
HWI77_11280	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HWI77_11290	COG4122	O-methyltransferase activity
HWI77_11300	COG0110	maltose O-acetyltransferase activity
HWI77_11320	COG1538	Outer membrane efflux protein
HWI77_11325	COG1137	ATPase activity
HWI77_11330	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HWI77_11340	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HWI77_11345	COG0517	IMP dehydrogenase activity
HWI77_11345	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HWI77_11360	COG0584	glycerophosphoryl diester phosphodiesterase
HWI77_11365	COG3015	lipoprotein NlpE involved in copper resistance
HWI77_11380	COG1253	flavin adenine dinucleotide binding
HWI77_11385	COG0222	ribosome binding
HWI77_11415	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HWI77_11425	COG1773	rubredoxin
HWI77_11430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWI77_11440	COG0583	DNA-binding transcription factor activity
HWI77_11460	COG3179	chitinase
HWI77_11590	COG3566	protein conserved in bacteria
HWI77_11790	COG0556	nucleotide-excision repair
HWI77_11810	COG0436	Aminotransferase
HWI77_11845	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HWI77_11850	COG3161	chorismate lyase activity
HWI77_11855	COG0174	glutamine synthetase
HWI77_11860	COG0512	Glutamine amidotransferase of anthranilate synthase
HWI77_11870	COG0633	Ferredoxin
HWI77_11870	COG3217	Mosc domain protein beta barrel domain protein
HWI77_11890	COG0302	gtp cyclohydrolase
HWI77_11910	COG3739	integral membrane protein
HWI77_12010	COG3107	peptidoglycan biosynthetic process
HWI77_12040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWI77_12045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWI77_12050	COG0006	proline dipeptidase activity
HWI77_12055	COG3079	Belongs to the UPF0149 family
HWI77_12080	COG2217	Heavy metal translocating P-type atpase
HWI77_12120	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HWI77_12135	COG3384	dioxygenase
HWI77_12145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWI77_12155	COG2878	Part of a membrane complex involved in electron transport
HWI77_12160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HWI77_12185	COG0768	penicillin binding
HWI77_12190	COG0742	ribosomal rna small subunit methyltransferase
HWI77_12215	COG0616	signal peptide processing
HWI77_12220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HWI77_12230	COG0573	inorganic phosphate transmembrane transporter activity
HWI77_12250	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HWI77_12295	COG0783	Belongs to the Dps family
HWI77_12330	COG0842	Transport permease protein
HWI77_12335	COG0842	Transport permease protein
HWI77_12340	COG1131	(ABC) transporter
HWI77_12375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWI77_12430	COG3052	prosthetic group binding
HWI77_12435	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HWI77_12445	COG0745	RESPONSE REGULATOR receiver
HWI77_12450	COG2205	protein histidine kinase activity
HWI77_12455	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HWI77_12460	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HWI77_12465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HWI77_12475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWI77_12480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWI77_12505	COG2814	Major facilitator Superfamily
HWI77_12510	COG1566	PFAM secretion protein HlyD family protein
HWI77_12515	COG2050	protein possibly involved in aromatic compounds catabolism
HWI77_12525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWI77_12530	COG3320	Male sterility
HWI77_12530	COG1022	Amp-dependent synthetase and ligase
HWI77_12550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWI77_12555	COG0420	3'-5' exonuclease activity
HWI77_12585	COG0735	belongs to the Fur family
HWI77_12590	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HWI77_12595	COG2914	Belongs to the UPF0125 (RnfH) family
HWI77_12610	COG0121	glutamine amidotransferase
HWI77_12630	COG0756	dUTP diphosphatase activity
HWI77_12635	COG0210	DNA helicase
HWI77_12640	COG2885	chlorophyll binding
HWI77_12645	COG0204	Acyl-transferase
HWI77_12665	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HWI77_12675	COG1280	lysine exporter protein (LysE YggA)
HWI77_12680	COG1674	ftsk spoiiie
HWI77_12685	COG0492	ferredoxin-NADP+ reductase activity
HWI77_12690	COG0500	methyltransferase
HWI77_12695	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HWI77_12705	COG0456	acetyltransferase
HWI77_12730	COG0049	tRNA binding
HWI77_12750	COG1981	membrane
HWI77_12765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HWI77_12765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HWI77_12790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HWI77_12815	COG0564	pseudouridine synthase activity
HWI77_12825	COG0358	DNA primase activity
HWI77_12840	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HWI77_12870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HWI77_12905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HWI77_12915	COG0352	thiamine-phosphate diphosphorylase activity
HWI77_12915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HWI77_12915	COG0351	phosphomethylpyrimidine kinase
HWI77_12920	COG0625	glutathione transferase activity
HWI77_12925	COG1652	LysM domain
HWI77_12935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWI77_12955	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HWI77_12960	COG1399	metal-binding, possibly nucleic acid-binding protein
HWI77_12965	COG3101	peptidyl-lysine hydroxylation
HWI77_12970	COG0009	L-threonylcarbamoyladenylate synthase
HWI77_12985	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HWI77_12990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HWI77_13010	COG0601	transmembrane transport
HWI77_13025	COG4166	transmembrane transport
HWI77_13070	COG4106	trans-aconitate 2-methyltransferase activity
HWI77_13080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HWI77_13080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HWI77_13085	COG0596	Alpha beta hydrolase
HWI77_13090	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HWI77_13110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HWI77_13120	COG1196	nuclear chromosome segregation
HWI77_13140	COG0730	response to heat
HWI77_13160	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HWI77_13175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HWI77_13200	COG0644	oxidoreductase
HWI77_13225	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HWI77_13230	COG0489	protein tyrosine kinase activity
HWI77_13255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWI77_13255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWI77_13265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWI77_13275	COG4716	Myosin-crossreactive antigen
HWI77_13280	COG2226	methyltransferase
HWI77_13305	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HWI77_13315	COG2081	HI0933 family
HWI77_13325	COG0668	transmembrane transport
HWI77_13340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWI77_13345	COG0583	DNA-binding transcription factor activity
HWI77_13350	COG1278	Cold shock
HWI77_13370	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWI77_13375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWI77_13380	COG0713	ATP synthesis coupled electron transport
HWI77_13390	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWI77_13405	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HWI77_13440	COG2205	protein histidine kinase activity
HWI77_13445	COG0745	RESPONSE REGULATOR receiver
HWI77_13460	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWI77_13470	COG3293	Transposase
HWI77_13495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWI77_13500	COG1309	transcriptional regulator
HWI77_13520	COG1063	alcohol dehydrogenase
HWI77_13560	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HWI77_13565	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HWI77_13570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWI77_13595	COG2132	Multicopper oxidase
HWI77_13605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HWI77_13630	COG1968	undecaprenyl-diphosphatase activity
HWI77_13635	COG1214	PFAM Peptidase M22, glycoprotease
HWI77_13645	COG0494	nUDIX hydrolase
HWI77_13695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HWI77_13710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HWI77_13715	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HWI77_13790	COG1846	Transcriptional regulator
HWI77_13795	COG1764	response to oxidative stress
HWI77_13820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWI77_13820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWI77_13835	COG0037	tRNA processing
HWI77_13870	COG0072	phenylalanine-tRNA ligase activity
HWI77_13885	COG1247	-acetyltransferase
HWI77_13910	COG1238	metal cluster binding
HWI77_13915	COG0625	glutathione transferase activity
HWI77_13935	COG0318	PFAM AMP-dependent synthetase and ligase
HWI77_13965	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HWI77_13970	COG0617	tRNA 3'-terminal CCA addition
HWI77_13975	COG1555	photosystem II stabilization
HWI77_13980	COG3956	TIGRFAM MazG family protein
HWI77_13990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWI77_14010	COG5002	protein histidine kinase activity
HWI77_14010	COG0784	Response regulator, receiver
HWI77_14010	COG2205	protein histidine kinase activity
HWI77_14020	COG2084	Dehydrogenase
HWI77_14025	COG3622	Belongs to the hyi family
HWI77_14040	COG0004	ammonium transporteR
HWI77_14070	COG0789	Transcriptional regulator
HWI77_14080	COG2814	Major facilitator Superfamily
HWI77_14085	COG5285	phytanoyl-CoA dioxygenase
HWI77_14090	COG1917	Cupin 2, conserved barrel domain protein
HWI77_14100	COG0456	acetyltransferase
HWI77_14110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HWI77_14125	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HWI77_14145	COG0084	hydrolase, TatD family'
HWI77_14160	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HWI77_14200	COG0431	NADPH-dependent FMN reductase
HWI77_14205	COG0798	PFAM Bile acid sodium symporter
HWI77_14215	COG0640	Transcriptional regulator
HWI77_14235	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HWI77_14240	COG0440	acetolactate synthase activity
HWI77_14245	COG0028	Belongs to the TPP enzyme family
HWI77_14275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWI77_14280	COG0577	efflux transmembrane transporter activity
HWI77_14280	COG1136	(ABC) transporter
HWI77_14285	COG1538	Outer membrane efflux protein
HWI77_14315	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HWI77_14320	COG1162	GTPase activity
HWI77_14365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HWI77_14375	COG3781	membrane
HWI77_14385	COG0613	PHP domain protein
HWI77_14415	COG1666	GTP binding
HWI77_14430	COG1956	GAF domain-containing protein
HWI77_14435	COG1607	acyl-coa hydrolase
HWI77_14490	COG1183	phosphatidylcholine synthase activity
HWI77_14495	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HWI77_14525	COG0739	heme binding
HWI77_14525	COG0741	lytic transglycosylase activity
HWI77_14525	COG1196	nuclear chromosome segregation
HWI77_14535	COG1702	phosphate starvation-inducible protein PhoH
HWI77_14580	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HWI77_14620	COG0788	formyltetrahydrofolate deformylase activity
HWI77_14645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWI77_14645	COG4651	solute:proton antiporter activity
HWI77_14665	COG0724	RNA recognition motif
HWI77_14695	COG1733	regulation of RNA biosynthetic process
HWI77_14705	COG2900	Belongs to the SlyX family
HWI77_14710	COG0488	(ABC) transporter
HWI77_14785	COG0473	3-isopropylmalate dehydrogenase activity
HWI77_14830	COG0494	nUDIX hydrolase
HWI77_14850	COG3011	Protein conserved in bacteria
HWI77_14865	COG0583	DNA-binding transcription factor activity
HWI77_14870	COG0625	glutathione transferase activity
HWI77_14880	COG0546	phosphoglycolate phosphatase activity
HWI77_14895	COG0318	PFAM AMP-dependent synthetase and ligase
HWI77_14920	COG0534	Mate efflux family protein
HWI77_14925	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HWI77_14985	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HWI77_14990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWI77_15025	COG1595	DNA-templated transcription, initiation
HWI77_15035	COG3220	belongs to the UPF0276 family
HWI77_15050	COG0425	Belongs to the sulfur carrier protein TusA family
HWI77_15055	COG4535	Mg2 and Co2 transporter CorC
HWI77_15060	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HWI77_15080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HWI77_15090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HWI77_15095	COG0583	DNA-binding transcription factor activity
HWI77_15100	COG0778	Nitroreductase
HWI77_15105	COG0697	spore germination
HWI77_15115	COG0789	Transcriptional regulator
HWI77_15120	COG0598	Magnesium transport protein CorA
HWI77_15135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWI77_15140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HWI77_15170	COG2226	methyltransferase
HWI77_15180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HWI77_15185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWI77_15195	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HWI77_15205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HWI77_15210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWI77_15210	COG2111	Na H antiporter
HWI77_15215	COG1006	Multisubunit Na H antiporter MnhC subunit
HWI77_15225	COG1863	multisubunit Na H antiporter MnhE subunit
HWI77_15230	COG2212	antiporter activity
HWI77_15235	COG1320	monovalent cation:proton antiporter activity
HWI77_15245	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HWI77_15255	COG0195	Participates in both transcription termination and antitermination
HWI77_15280	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HWI77_15305	COG0237	dephospho-CoA kinase activity
HWI77_15315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HWI77_15330	COG0497	DNA recombination
HWI77_15340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HWI77_15370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HWI77_15400	COG3706	GGDEF domain
HWI77_15445	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HWI77_15465	COG0326	Molecular chaperone. Has ATPase activity
HWI77_15485	COG2056	Na+-H+ antiporter family
HWI77_15530	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HWI77_15580	COG0546	phosphoglycolate phosphatase activity
HWI77_15585	COG1716	ATPase activity
HWI77_15630	COG0181	hydroxymethylbilane synthase activity
HWI77_15640	COG3275	phosphorelay sensor kinase activity
HWI77_15680	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HWI77_15685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HWI77_15715	COG4974	Belongs to the 'phage' integrase family
HWI77_15720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWI77_15730	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HWI77_15745	COG2197	response regulator
HWI77_15760	COG0793	Belongs to the peptidase S41A family
HWI77_15765	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HWI77_15770	COG0795	lipopolysaccharide-transporting ATPase activity
HWI77_15775	COG0795	lipopolysaccharide-transporting ATPase activity
HWI77_15810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWI77_15810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWI77_15820	COG0004	ammonium transporteR
HWI77_15825	COG0347	Belongs to the P(II) protein family
HWI77_15855	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HWI77_15870	COG0318	PFAM AMP-dependent synthetase and ligase
HWI77_15890	COG2860	membrane
HWI77_15900	COG1253	flavin adenine dinucleotide binding
HWI77_15915	COG2814	Major facilitator Superfamily
HWI77_15930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HWI77_15935	COG0745	RESPONSE REGULATOR receiver
HWI77_15940	COG2205	protein histidine kinase activity
HWI77_15945	COG4452	Inner membrane protein CreD
HWI77_15975	COG2814	Major facilitator Superfamily
HWI77_15995	COG0655	NAD(P)H dehydrogenase (quinone) activity
HWI77_16015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HWI77_16025	COG1283	sodium-dependent phosphate transmembrane transporter activity
HWI77_16060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWI77_16080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWI77_16085	COG3162	membrane
HWI77_16090	COG0784	Response regulator, receiver
HWI77_16090	COG2205	protein histidine kinase activity
HWI77_16115	COG1652	LysM domain
HWI77_16120	COG0758	DNA mediated transformation
HWI77_16135	COG1309	transcriptional regulator
HWI77_16150	COG0386	Belongs to the glutathione peroxidase family
HWI77_16170	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HWI77_16175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HWI77_16185	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HWI77_16225	COG1121	(ABC) transporter
HWI77_16230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWI77_16240	COG2837	iron assimilation
HWI77_16245	COG0281	malic enzyme
HWI77_16295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HWI77_16295	COG0519	Catalyzes the synthesis of GMP from XMP
HWI77_16300	COG4399	Belongs to the UPF0754 family
HWI77_16305	COG3111	PFAM Bacterial OB fold (BOF) protein
HWI77_16310	COG2259	Doxx family
HWI77_16315	COG0586	Pfam SNARE associated Golgi protein
HWI77_16330	COG1192	Involved in chromosome partitioning
HWI77_16340	COG0271	Belongs to the BolA IbaG family
HWI77_16355	COG0477	Major facilitator Superfamily
HWI77_16375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWI77_16400	COG1113	amino acid transport
HWI77_16405	COG0251	oxidation-reduction process
HWI77_16430	COG0456	acetyltransferase
HWI77_16435	COG0564	pseudouridine synthase activity
HWI77_16475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HWI77_16490	COG1802	Transcriptional regulator
HWI77_16500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HWI77_16505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HWI77_16520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HWI77_16530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HWI77_16540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HWI77_16555	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HWI77_16580	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HWI77_16585	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HWI77_16610	COG0545	Peptidyl-prolyl cis-trans isomerase
HWI77_16620	COG3023	N-Acetylmuramoyl-L-alanine amidase
HWI77_16645	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HWI77_16680	COG0546	phosphoglycolate phosphatase activity
HWI77_16685	COG1028	Short-chain dehydrogenase reductase Sdr
HWI77_16695	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HWI77_16695	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HWI77_16700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWI77_16705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWI77_16710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWI77_16715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWI77_16720	COG1116	anion transmembrane transporter activity
HWI77_16725	COG1309	transcriptional regulator
HWI77_16745	COG0196	riboflavin kinase activity
HWI77_16750	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HWI77_16760	COG1047	Peptidyl-prolyl cis-trans
HWI77_16800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HWI77_16805	COG0657	acetylesterase activity
HWI77_16840	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HWI77_16850	COG5549	protein import
HWI77_16850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWI77_16865	COG2951	lytic endotransglycosylase activity
HWI77_16870	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HWI77_16885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HWI77_16920	COG0861	Integral membrane protein TerC family
HWI77_16925	COG0402	S-adenosylhomocysteine deaminase activity
HWI77_16940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWI77_16955	COG0706	membrane insertase activity
HWI77_16975	COG2188	Transcriptional regulator
HWI77_16985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWI77_16990	COG0243	molybdopterin cofactor binding
HWI77_17010	COG4628	conserved protein (DUF2132)
HWI77_17025	COG0791	NLP P60 protein
HWI77_17040	COG0583	DNA-binding transcription factor activity
HWI77_17055	COG3023	N-Acetylmuramoyl-L-alanine amidase
HWI77_17080	COG1840	ABC-type Fe3 transport system, periplasmic component
HWI77_17085	COG1609	Transcriptional regulator
HWI77_17135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HWI77_17175	COG1741	Belongs to the pirin family
HWI77_17180	COG0583	DNA-binding transcription factor activity
HWI77_17200	COG1175	transmembrane transport
HWI77_17210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWI77_17215	COG3842	ATPase activity
HWI77_17220	COG0477	Major facilitator Superfamily
HWI77_17240	COG1063	alcohol dehydrogenase
HWI77_17290	COG2066	Belongs to the glutaminase family
HWI77_17295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HWI77_17305	COG3182	Iron-regulated membrane protein
HWI77_17310	COG1064	alcohol dehydrogenase
HWI77_17330	COG0583	DNA-binding transcription factor activity
HWI77_17340	COG3706	GGDEF domain
HWI77_17350	COG1349	DNA-binding transcription factor activity
HWI77_17355	COG2223	nitrite transmembrane transporter activity
HWI77_17395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWI77_17400	COG1309	transcriptional regulator
HWI77_17405	COG0251	oxidation-reduction process
HWI77_17425	COG0583	DNA-binding transcription factor activity
HWI77_17440	COG4974	Belongs to the 'phage' integrase family
HWI77_17455	COG2205	protein histidine kinase activity
HWI77_17460	COG0745	RESPONSE REGULATOR receiver
HWI77_17465	COG1276	copper resistance
HWI77_17475	COG3667	copper resistance
HWI77_17480	COG2132	Multicopper oxidase
HWI77_17500	COG2204	response regulator
HWI77_17505	COG2207	Transcriptional regulator
HWI77_17510	COG4221	oxidoreductase activity
HWI77_17515	COG0598	Magnesium transport protein CorA
HWI77_17525	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HWI77_17530	COG1396	sequence-specific DNA binding
HWI77_17535	COG2271	Major facilitator Superfamily
HWI77_17545	COG1012	belongs to the aldehyde dehydrogenase family
HWI77_17570	COG0561	phosphatase activity
HWI77_17580	COG1064	alcohol dehydrogenase
HWI77_17585	COG3706	GGDEF domain
HWI77_17590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HWI77_17595	COG3729	General stress protein
HWI77_17615	COG0024	Methionine aminopeptidase
HWI77_17635	COG1846	Transcriptional regulator
HWI77_17640	COG2135	peptidase activity
HWI77_17655	COG2200	EAL domain
HWI77_17690	COG1028	Short-chain dehydrogenase reductase Sdr
HWI77_17740	COG2207	Transcriptional regulator
HWI77_17745	COG4221	oxidoreductase activity
HWI77_17760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWI77_17775	COG1280	lysine exporter protein (LysE YggA)
HWI77_17785	COG4773	Receptor
HWI77_17805	COG4221	oxidoreductase activity
HWI77_17835	COG1082	Xylose isomerase domain protein TIM barrel
HWI77_17845	COG1120	ATPase activity
HWI77_17850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWI77_17860	COG0523	cobalamin synthesis protein
HWI77_17865	COG2211	Major facilitator Superfamily
HWI77_17880	COG1609	Transcriptional regulator
HWI77_17890	COG0583	DNA-binding transcription factor activity
HWI77_17895	COG1902	pentaerythritol trinitrate reductase activity
HWI77_17910	COG2916	Histone family protein nucleoid-structuring protein H-NS
HWI77_17915	COG1473	amidohydrolase
HWI77_17950	COG1271	oxidase subunit
HWI77_17960	COG3383	formate dehydrogenase (NAD+) activity
HWI77_17965	COG1028	Short-chain dehydrogenase reductase Sdr
HWI77_17970	COG3387	PFAM Glycoside hydrolase 15-related
HWI77_17975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HWI77_17995	COG0477	Major facilitator Superfamily
HWI77_18000	COG3237	CsbD-like
HWI77_18005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HWI77_18020	COG0840	transmembrane signaling receptor activity
HWI77_18035	COG0438	transferase activity, transferring glycosyl groups
HWI77_18040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWI77_18045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWI77_18060	COG0765	amino acid transport
HWI77_18065	COG1126	abc transporter atp-binding protein
HWI77_18075	COG2200	EAL domain
HWI77_18080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HWI77_18090	COG3141	response to X-ray
HWI77_18095	COG0840	transmembrane signaling receptor activity
HWI77_18100	COG3038	cytochrome b561
HWI77_18120	COG3122	Protein conserved in bacteria
HWI77_18130	COG1649	PFAM Uncharacterised BCR, COG1649
HWI77_18145	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HWI77_18155	COG0076	glutamate decarboxylase activity
HWI77_18160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HWI77_18185	COG0726	polysaccharide deacetylase
HWI77_18190	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HWI77_18195	COG2076	Multidrug Resistance protein
HWI77_18200	COG2076	Multidrug Resistance protein
HWI77_18210	COG0673	inositol 2-dehydrogenase activity
HWI77_18215	COG0814	amino acid
HWI77_18225	COG1902	pentaerythritol trinitrate reductase activity
HWI77_18245	COG3833	ABC-type maltose transport systems, permease component
HWI77_18250	COG1175	transmembrane transport
HWI77_18255	COG2182	Extracellular solute-binding protein
HWI77_18275	COG1640	4-alpha-glucanotransferase
HWI77_18280	COG0058	SHG alpha-glucan phosphorylase activity
HWI77_18300	COG3093	addiction module antidote protein HigA
HWI77_18320	COG3011	Protein conserved in bacteria
HWI77_18325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HWI77_18330	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HWI77_18335	COG2080	2 iron, 2 sulfur cluster binding
HWI77_18350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWI77_18355	COG1464	Belongs to the NlpA lipoprotein family
HWI77_18365	COG3158	transport of potassium into the cell
HWI77_18390	COG0583	DNA-binding transcription factor activity
HWI77_18395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWI77_18400	COG1288	antiporter activity
HWI77_18405	COG0840	transmembrane signaling receptor activity
HWI77_18410	COG4774	siderophore transport
HWI77_18430	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HWI77_18435	COG0076	glutamate decarboxylase activity
HWI77_18440	COG1278	Cold shock
HWI77_18445	COG1403	HNH endonuclease
HWI77_18460	COG2199	diguanylate cyclase activity
HWI77_18465	COG2885	chlorophyll binding
HWI77_18475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWI77_18515	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HWI77_18520	COG1012	belongs to the aldehyde dehydrogenase family
HWI77_18525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWI77_18530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWI77_18535	COG2267	carboxylic ester hydrolase activity
HWI77_18605	COG0583	DNA-binding transcription factor activity
HWI77_18685	COG0789	Transcriptional regulator
HWI77_18690	COG0531	amino acid
HWI77_18700	COG0840	transmembrane signaling receptor activity
HWI77_18705	COG1028	Short-chain dehydrogenase reductase Sdr
HWI77_18770	COG2807	transmembrane transport
HWI77_18775	COG2207	Transcriptional regulator
HWI77_18840	COG0583	DNA-binding transcription factor activity
HWI77_18845	COG2814	Major facilitator Superfamily
HWI77_18905	COG2161	toxin-antitoxin pair type II binding
HWI77_18920	COG2304	oxidoreductase activity
HWI77_18970	COG1358	cellular component organization or biogenesis
HWI77_18995	COG4993	Dehydrogenase
HWI77_19015	COG2026	Addiction module toxin, RelE StbE family
HWI77_19020	COG3077	Addiction module antitoxin, RelB DinJ family
HWI77_19035	COG5001	Diguanylate cyclase
HWI77_19035	COG3300	MHYT domain
HWI77_19040	COG5001	Diguanylate cyclase
HWI77_19080	COG1794	racemase activity, acting on amino acids and derivatives
HWI77_19100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWI77_19120	COG0366	Alpha amylase catalytic
HWI77_19130	COG2188	Transcriptional regulator
HWI77_19140	COG2222	sugar isomerase
HWI77_19320	COG0756	dUTP diphosphatase activity
HWI77_19655	COG2974	May be involved in recombination
HWI77_19700	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system