locus-tag	class	description
CDG68_00125	COG1192	Involved in chromosome partitioning
CDG68_00185	COG1196	nuclear chromosome segregation
CDG68_00185	COG0741	lytic transglycosylase activity
CDG68_00185	COG0739	heme binding
CDG68_00200	COG0739	heme binding
CDG68_00200	COG1196	nuclear chromosome segregation
CDG68_00200	COG0741	lytic transglycosylase activity
CDG68_00210	COG3451	type IV secretory pathway VirB4
CDG68_00565	COG4772	TonB-dependent receptor
CDG68_00605	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CDG68_00610	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CDG68_00615	COG3657	addiction module killer protein
CDG68_00630	COG1309	transcriptional regulator
CDG68_00710	COG2337	Toxic component of a toxin-antitoxin (TA) module
CDG68_00715	COG2336	PFAM SpoVT AbrB
CDG68_00750	COG3173	Aminoglycoside phosphotransferase
CDG68_00905	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CDG68_00910	COG3657	addiction module killer protein
CDG68_00995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CDG68_01155	COG2826	transposase and inactivated derivatives, IS30 family
CDG68_01165	COG2826	transposase and inactivated derivatives, IS30 family
CDG68_01205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CDG68_01240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDG68_01260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDG68_01265	COG0625	glutathione transferase activity
CDG68_01305	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CDG68_01315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CDG68_01335	COG2009	succinate dehydrogenase
CDG68_01520	COG1475	DNA binding
CDG68_01525	COG1192	Involved in chromosome partitioning
CDG68_01575	COG1061	Type III restriction enzyme res subunit
CDG68_01585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CDG68_01590	COG1192	Involved in chromosome partitioning
CDG68_01600	COG1061	Type III restriction enzyme res subunit
CDG68_01880	COG4783	chaperone-mediated protein folding
CDG68_01955	COG4372	Transposase
CDG68_01975	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CDG68_02000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CDG68_02005	COG2076	Multidrug Resistance protein
CDG68_02070	COG2801	Transposase and inactivated derivatives
CDG68_02100	COG3173	Aminoglycoside phosphotransferase
CDG68_02170	COG1660	Displays ATPase and GTPase activities
CDG68_02190	COG0860	N-Acetylmuramoyl-L-alanine amidase
CDG68_02305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CDG68_02345	COG3421	Type III restriction
CDG68_02350	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CDG68_02370	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CDG68_02435	COG3706	GGDEF domain
CDG68_02440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDG68_02445	COG0183	Belongs to the thiolase family
CDG68_02460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDG68_02465	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CDG68_02475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDG68_02540	COG1525	nuclease
CDG68_02595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CDG68_02600	COG2076	Multidrug Resistance protein
CDG68_02645	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
CDG68_02665	COG3328	transposase activity
CDG68_02675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDG68_02720	COG1192	Involved in chromosome partitioning
CDG68_02725	COG1475	DNA binding
CDG68_02755	COG2184	nucleotidyltransferase activity
CDG68_02930	COG0592	DNA-directed DNA polymerase activity
CDG68_02940	COG0187	DNA topoisomerase II activity
CDG68_02950	COG0488	(ABC) transporter
CDG68_02985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CDG68_02995	COG1061	Type III restriction enzyme res subunit
CDG68_03000	COG1002	Type II restriction enzyme, methylase subunits
CDG68_03015	COG4584	PFAM Integrase catalytic
CDG68_03020	COG1484	DNA-dependent DNA replication
CDG68_03030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CDG68_03035	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CDG68_03070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CDG68_03205	COG1309	transcriptional regulator
CDG68_03210	COG1116	anion transmembrane transporter activity
CDG68_03215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDG68_03220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CDG68_03225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDG68_03230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDG68_03235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CDG68_03235	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CDG68_03255	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_03260	COG0546	phosphoglycolate phosphatase activity
CDG68_03265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CDG68_03280	COG1309	transcriptional regulator
CDG68_03290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDG68_03290	COG1017	nitric oxide dioxygenase activity
CDG68_03325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDG68_03330	COG2814	Major facilitator Superfamily
CDG68_03335	COG1335	isochorismatase
CDG68_03340	COG0385	Bile acid
CDG68_03345	COG1683	Conserved Protein
CDG68_03355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CDG68_03390	COG3023	N-Acetylmuramoyl-L-alanine amidase
CDG68_03420	COG1596	polysaccharide export
CDG68_03430	COG1442	glycosyl transferase family 8
CDG68_03430	COG1216	Glycosyl transferase, family 2
CDG68_03440	COG0438	transferase activity, transferring glycosyl groups
CDG68_03450	COG1216	Glycosyl transferase, family 2
CDG68_03455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CDG68_03460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CDG68_03475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CDG68_03480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDG68_03505	COG1846	Transcriptional regulator
CDG68_03510	COG2309	aminopeptidase activity
CDG68_03515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDG68_03520	COG0596	Alpha beta hydrolase
CDG68_03525	COG3473	Maleate cis-trans isomerase
CDG68_03530	COG1335	isochorismatase
CDG68_03535	COG2271	Major facilitator Superfamily
CDG68_03550	COG0583	DNA-binding transcription factor activity
CDG68_03570	COG1012	belongs to the aldehyde dehydrogenase family
CDG68_03585	COG4628	conserved protein (DUF2132)
CDG68_03595	COG3209	COG3209 Rhs family protein
CDG68_03650	COG0271	Belongs to the BolA IbaG family
CDG68_03660	COG1192	Involved in chromosome partitioning
CDG68_03670	COG0586	Pfam SNARE associated Golgi protein
CDG68_03675	COG2259	Doxx family
CDG68_03685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CDG68_03685	COG0519	Catalyzes the synthesis of GMP from XMP
CDG68_03720	COG1902	pentaerythritol trinitrate reductase activity
CDG68_03725	COG1519	Transferase
CDG68_03730	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CDG68_03735	COG0668	transmembrane transport
CDG68_03745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDG68_03765	COG0431	NADPH-dependent FMN reductase
CDG68_03775	COG2814	Major facilitator Superfamily
CDG68_03805	COG4452	Inner membrane protein CreD
CDG68_03810	COG2205	protein histidine kinase activity
CDG68_03820	COG0745	RESPONSE REGULATOR receiver
CDG68_03845	COG0281	malic enzyme
CDG68_03850	COG3501	Rhs element vgr protein
CDG68_03895	COG2837	iron assimilation
CDG68_03900	COG1280	lysine exporter protein (LysE YggA)
CDG68_03905	COG1280	lysine exporter protein (LysE YggA)
CDG68_03910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CDG68_03915	COG1121	(ABC) transporter
CDG68_03925	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CDG68_03955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CDG68_03965	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CDG68_04000	COG0386	Belongs to the glutathione peroxidase family
CDG68_04015	COG2814	Major facilitator Superfamily
CDG68_04020	COG1309	transcriptional regulator
CDG68_04025	COG0697	spore germination
CDG68_04030	COG0009	L-threonylcarbamoyladenylate synthase
CDG68_04035	COG0758	DNA mediated transformation
CDG68_04040	COG1652	LysM domain
CDG68_04070	COG1309	transcriptional regulator
CDG68_04105	COG2133	pyrroloquinoline quinone binding
CDG68_04115	COG0655	NAD(P)H dehydrogenase (quinone) activity
CDG68_04140	COG2205	protein histidine kinase activity
CDG68_04140	COG0784	Response regulator, receiver
CDG68_04145	COG3162	membrane
CDG68_04150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CDG68_04160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CDG68_04180	COG3706	GGDEF domain
CDG68_04220	COG1253	flavin adenine dinucleotide binding
CDG68_04235	COG2860	membrane
CDG68_04240	COG0477	Major facilitator Superfamily
CDG68_04265	COG0318	PFAM AMP-dependent synthetase and ligase
CDG68_04280	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CDG68_04310	COG0606	chelatase, subunit chli
CDG68_04320	COG0347	Belongs to the P(II) protein family
CDG68_04325	COG0004	ammonium transporteR
CDG68_04335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDG68_04335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDG68_04350	COG0586	Pfam SNARE associated Golgi protein
CDG68_04360	COG0772	Belongs to the SEDS family
CDG68_04365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDG68_04370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CDG68_04375	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CDG68_04385	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CDG68_04415	COG0488	(ABC) transporter
CDG68_04445	COG2329	Antibiotic biosynthesis monooxygenase
CDG68_04450	COG0697	spore germination
CDG68_04485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CDG68_04530	COG0427	acetyl-CoA hydrolase
CDG68_04535	COG2205	protein histidine kinase activity
CDG68_04540	COG0745	RESPONSE REGULATOR receiver
CDG68_04555	COG4221	oxidoreductase activity
CDG68_04635	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CDG68_04660	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CDG68_04665	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CDG68_04670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CDG68_04675	COG2226	methyltransferase
CDG68_04725	COG0069	glutamate synthase activity
CDG68_04725	COG0067	glutamate synthase
CDG68_04725	COG0070	glutamate synthase
CDG68_04730	COG0493	'glutamate synthase
CDG68_04740	COG0307	riboflavin synthase, alpha
CDG68_04750	COG2212	antiporter activity
CDG68_04760	COG0651	ATP synthesis coupled electron transport
CDG68_04765	COG1006	Multisubunit Na H antiporter MnhC subunit
CDG68_04770	COG2111	Na H antiporter
CDG68_04770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CDG68_04800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CDG68_04825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CDG68_04855	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CDG68_04860	COG1074	ATP-dependent DNA helicase activity
CDG68_04865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CDG68_04890	COG0598	Magnesium transport protein CorA
CDG68_04900	COG0789	Transcriptional regulator
CDG68_04905	COG0484	heat shock protein binding
CDG68_04915	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CDG68_04925	COG2226	methyltransferase
CDG68_04970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CDG68_05035	COG0517	IMP dehydrogenase activity
CDG68_05040	COG1983	PspC domain protein
CDG68_05070	COG0318	PFAM AMP-dependent synthetase and ligase
CDG68_05075	COG1530	ribonuclease E activity
CDG68_05080	COG0564	pseudouridine synthase activity
CDG68_05085	COG0546	phosphoglycolate phosphatase activity
CDG68_05090	COG3971	2-oxopent-4-enoate hydratase activity
CDG68_05095	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CDG68_05110	COG1473	amidohydrolase
CDG68_05130	COG2161	toxin-antitoxin pair type II binding
CDG68_05140	COG0583	DNA-binding transcription factor activity
CDG68_05145	COG4638	Rieske (2fe-2S)
CDG68_05165	COG3384	dioxygenase
CDG68_05170	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDG68_05175	COG0456	acetyltransferase
CDG68_05205	COG3011	Protein conserved in bacteria
CDG68_05210	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CDG68_05225	COG1960	acyl-CoA dehydrogenase activity
CDG68_05240	COG1522	sequence-specific DNA binding
CDG68_05245	COG1280	lysine exporter protein (LysE YggA)
CDG68_05260	COG0494	nUDIX hydrolase
CDG68_05275	COG0583	DNA-binding transcription factor activity
CDG68_05290	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CDG68_05305	COG0473	3-isopropylmalate dehydrogenase activity
CDG68_05320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CDG68_05335	COG0101	tRNA pseudouridine synthase activity
CDG68_05340	COG0252	asparaginase activity
CDG68_05385	COG1560	Kdo2-lipid A biosynthetic process
CDG68_05445	COG1929	Belongs to the glycerate kinase type-1 family
CDG68_05455	COG0210	DNA helicase
CDG68_05475	COG4651	solute:proton antiporter activity
CDG68_05475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CDG68_05480	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CDG68_05485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CDG68_05500	COG0788	formyltetrahydrofolate deformylase activity
CDG68_05525	COG3453	Protein conserved in bacteria
CDG68_05525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDG68_05540	COG1607	acyl-coa hydrolase
CDG68_05575	COG2350	Protein conserved in bacteria
CDG68_05585	COG0613	PHP domain protein
CDG68_05595	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CDG68_05600	COG1702	phosphate starvation-inducible protein PhoH
CDG68_05605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CDG68_05610	COG1196	nuclear chromosome segregation
CDG68_05610	COG0739	heme binding
CDG68_05610	COG0741	lytic transglycosylase activity
CDG68_05645	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CDG68_05650	COG1183	phosphatidylcholine synthase activity
CDG68_05715	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CDG68_05720	COG3878	Protein conserved in bacteria
CDG68_05760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CDG68_05775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CDG68_05780	COG1063	alcohol dehydrogenase
CDG68_05790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CDG68_05790	COG2813	Specifically methylates the guanine in position
CDG68_05795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CDG68_05800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDG68_05810	COG3128	pkhd-type hydroxylase
CDG68_05815	COG4774	siderophore transport
CDG68_05820	COG4774	siderophore transport
CDG68_05825	COG4771	TonB-dependent receptor
CDG68_05835	COG0740	serine-type endopeptidase activity
CDG68_05885	COG0280	phosphate acetyltransferase
CDG68_05885	COG0857	belongs to the CobB CobQ family
CDG68_05890	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CDG68_05925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CDG68_05935	COG0726	polysaccharide deacetylase
CDG68_05940	COG0084	hydrolase, TatD family'
CDG68_05945	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CDG68_05955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CDG68_05990	COG2814	Major facilitator Superfamily
CDG68_06000	COG0789	Transcriptional regulator
CDG68_06015	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CDG68_06020	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CDG68_06025	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CDG68_06045	COG1862	Preprotein translocase
CDG68_06080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CDG68_06095	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CDG68_06120	COG0438	transferase activity, transferring glycosyl groups
CDG68_06145	COG2990	Protein conserved in bacteria
CDG68_06160	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CDG68_06190	COG3223	Belongs to the PsiE family
CDG68_06205	COG1960	acyl-CoA dehydrogenase activity
CDG68_06210	COG1960	acyl-CoA dehydrogenase activity
CDG68_06215	COG0318	PFAM AMP-dependent synthetase and ligase
CDG68_06250	COG0625	glutathione transferase activity
CDG68_06260	COG1238	metal cluster binding
CDG68_06280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CDG68_06285	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CDG68_06315	COG0072	phenylalanine-tRNA ligase activity
CDG68_06320	COG0776	regulation of translation
CDG68_06350	COG0037	tRNA processing
CDG68_06360	COG0762	integral membrane protein
CDG68_06380	COG0183	Belongs to the thiolase family
CDG68_06390	COG2885	chlorophyll binding
CDG68_06390	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CDG68_06395	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CDG68_06395	COG2885	chlorophyll binding
CDG68_06405	COG1690	Belongs to the RtcB family
CDG68_06410	COG0833	amino acid
CDG68_06420	COG2233	PERMEase
CDG68_06435	COG1970	mechanosensitive ion channel activity
CDG68_06450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDG68_06460	COG3659	wide pore channel activity
CDG68_06465	COG4772	TonB-dependent receptor
CDG68_06470	COG1902	pentaerythritol trinitrate reductase activity
CDG68_06485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CDG68_06495	COG0009	L-threonylcarbamoyladenylate synthase
CDG68_06500	COG3101	peptidyl-lysine hydroxylation
CDG68_06505	COG1399	metal-binding, possibly nucleic acid-binding protein
CDG68_06520	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_06525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDG68_06530	COG1652	LysM domain
CDG68_06535	COG0450	alkyl hydroperoxide reductase
CDG68_06550	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CDG68_06555	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CDG68_06585	COG2199	diguanylate cyclase activity
CDG68_06630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDG68_06630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDG68_06695	COG0489	protein tyrosine kinase activity
CDG68_06745	COG0644	oxidoreductase
CDG68_06750	COG0442	prolyl-tRNA aminoacylation
CDG68_06775	COG0840	transmembrane signaling receptor activity
CDG68_06805	COG2832	Protein of unknown function (DUF454)
CDG68_06870	COG1289	transmembrane transporter activity
CDG68_06875	COG2814	Major facilitator Superfamily
CDG68_06885	COG1090	epimerase
CDG68_06890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDG68_06900	COG2050	protein possibly involved in aromatic compounds catabolism
CDG68_06905	COG1566	PFAM secretion protein HlyD family protein
CDG68_06910	COG2814	Major facilitator Superfamily
CDG68_06955	COG0306	phosphate transporter
CDG68_06980	COG0175	sulfate reduction
CDG68_07045	COG2851	Citrate transporter
CDG68_07050	COG1253	flavin adenine dinucleotide binding
CDG68_07070	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CDG68_07075	COG2894	cell division
CDG68_07080	COG0850	regulation of cytokinetic process
CDG68_07090	COG0204	Acyl-transferase
CDG68_07095	COG2885	chlorophyll binding
CDG68_07100	COG0210	DNA helicase
CDG68_07105	COG0756	dUTP diphosphatase activity
CDG68_07110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDG68_07115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CDG68_07125	COG0121	glutamine amidotransferase
CDG68_07140	COG2914	Belongs to the UPF0125 (RnfH) family
CDG68_07145	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CDG68_07150	COG0735	belongs to the Fur family
CDG68_07195	COG0420	3'-5' exonuclease activity
CDG68_07225	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CDG68_07245	COG0786	glutamate:sodium symporter activity
CDG68_07250	COG2059	Chromate
CDG68_07255	COG1752	Esterase of the alpha-beta hydrolase superfamily
CDG68_07265	COG1607	acyl-coa hydrolase
CDG68_07275	COG1309	transcriptional regulator
CDG68_07280	COG2814	Major facilitator Superfamily
CDG68_07285	COG0583	DNA-binding transcription factor activity
CDG68_07300	COG2188	Transcriptional regulator
CDG68_07320	COG0523	cobalamin synthesis protein
CDG68_07325	COG4681	YaeQ
CDG68_07335	COG0726	polysaccharide deacetylase
CDG68_07335	COG1649	PFAM Uncharacterised BCR, COG1649
CDG68_07340	COG1215	transferase activity, transferring glycosyl groups
CDG68_07380	COG1024	Enoyl-CoA hydratase
CDG68_07395	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CDG68_07415	COG4771	TonB-dependent receptor
CDG68_07445	COG1113	amino acid transport
CDG68_07450	COG2828	Protein conserved in bacteria
CDG68_07460	COG0142	geranyltranstransferase activity
CDG68_07465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CDG68_07480	COG1752	Esterase of the alpha-beta hydrolase superfamily
CDG68_07515	COG2194	sulfuric ester hydrolase activity
CDG68_07520	COG0745	RESPONSE REGULATOR receiver
CDG68_07525	COG0642	Histidine kinase
CDG68_07535	COG0004	ammonium transporteR
CDG68_07570	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CDG68_07580	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CDG68_07585	COG1077	Cell shape determining protein MreB Mrl
CDG68_07590	COG1792	Involved in formation and maintenance of cell shape
CDG68_07595	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CDG68_07600	COG0424	maF-like protein
CDG68_07605	COG1530	ribonuclease E activity
CDG68_07610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDG68_07620	COG0560	Phosphoserine phosphatase
CDG68_07630	COG4181	ATPase activity
CDG68_07635	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CDG68_07640	COG0586	Pfam SNARE associated Golgi protein
CDG68_07655	COG1309	transcriptional regulator
CDG68_07665	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CDG68_07690	COG0193	aminoacyl-tRNA hydrolase activity
CDG68_07700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CDG68_07740	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CDG68_07750	COG0358	DNA primase activity
CDG68_07760	COG0564	pseudouridine synthase activity
CDG68_07780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CDG68_07790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDG68_07845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CDG68_07860	COG0477	Major facilitator Superfamily
CDG68_07880	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CDG68_07900	COG0459	protein refolding
CDG68_07905	COG2169	Transcriptional regulator
CDG68_07910	COG2223	nitrite transmembrane transporter activity
CDG68_07925	COG1840	ABC-type Fe3 transport system, periplasmic component
CDG68_07930	COG3842	ATPase activity
CDG68_07945	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CDG68_07950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CDG68_07975	COG0584	glycerophosphoryl diester phosphodiesterase
CDG68_07980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDG68_07985	COG2239	Acts as a magnesium transporter
CDG68_08025	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CDG68_08030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CDG68_08035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDG68_08050	COG1115	amino acid carrier protein
CDG68_08055	COG1113	amino acid transport
CDG68_08065	COG0019	diaminopimelate decarboxylase activity
CDG68_08070	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CDG68_08090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CDG68_08115	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
CDG68_08130	COG0833	amino acid
CDG68_08145	COG0833	amino acid
CDG68_08155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CDG68_08160	COG0418	dihydroorotase activity
CDG68_08180	COG0501	Belongs to the peptidase M48B family
CDG68_08185	COG0741	lytic transglycosylase activity
CDG68_08190	COG0037	tRNA processing
CDG68_08200	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CDG68_08210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CDG68_08305	COG0583	DNA-binding transcription factor activity
CDG68_08325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDG68_08335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CDG68_08340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CDG68_08350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CDG68_08355	COG1469	GTP cyclohydrolase I activity
CDG68_08360	COG0735	belongs to the Fur family
CDG68_08395	COG0523	cobalamin synthesis protein
CDG68_08400	COG0640	Transcriptional regulator
CDG68_08425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CDG68_08465	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CDG68_08470	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CDG68_08500	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CDG68_08505	COG4605	iron ion homeostasis
CDG68_08510	COG4604	ABC transporter, ATP-binding protein
CDG68_08515	COG4607	ABC-type enterochelin transport system periplasmic component
CDG68_08520	COG4774	siderophore transport
CDG68_08540	COG1595	DNA-templated transcription, initiation
CDG68_08545	COG3712	iron ion homeostasis
CDG68_08575	COG0412	Dienelactone hydrolase
CDG68_08580	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_08590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDG68_08605	COG0543	2 iron, 2 sulfur cluster binding
CDG68_08605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDG68_08610	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CDG68_08615	COG4638	Rieske (2fe-2S)
CDG68_08625	COG3706	GGDEF domain
CDG68_08625	COG0745	RESPONSE REGULATOR receiver
CDG68_08695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CDG68_08700	COG0183	Belongs to the thiolase family
CDG68_08705	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CDG68_08710	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CDG68_08715	COG4829	muconolactone delta-isomerase
CDG68_08720	COG4948	Mandelate Racemase Muconate Lactonizing
CDG68_08725	COG0583	DNA-binding transcription factor activity
CDG68_08730	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CDG68_08735	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CDG68_08740	COG3485	protocatechuate 3,4-dioxygenase
CDG68_08745	COG3135	benzoate transporter
CDG68_08750	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_08755	COG0633	Ferredoxin
CDG68_08755	COG0543	2 iron, 2 sulfur cluster binding
CDG68_08760	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CDG68_08765	COG4638	Rieske (2fe-2S)
CDG68_08770	COG0583	DNA-binding transcription factor activity
CDG68_08775	COG2814	Major facilitator Superfamily
CDG68_08780	COG3706	GGDEF domain
CDG68_08780	COG2203	Gaf domain
CDG68_08780	COG5001	Diguanylate cyclase
CDG68_08780	COG4251	negative regulation of phosphorylation
CDG68_08790	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CDG68_08815	COG2153	protein acetylation
CDG68_08825	COG0281	malic enzyme
CDG68_08825	COG0280	phosphate acetyltransferase
CDG68_08835	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CDG68_08845	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CDG68_08890	COG2050	protein possibly involved in aromatic compounds catabolism
CDG68_08895	COG1187	pseudouridine synthase activity
CDG68_08940	COG0583	DNA-binding transcription factor activity
CDG68_08945	COG0697	spore germination
CDG68_08955	COG2186	Transcriptional regulator
CDG68_08965	COG0277	FAD linked oxidase domain protein
CDG68_08980	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDG68_08980	COG1902	pentaerythritol trinitrate reductase activity
CDG68_09000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDG68_09005	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_09025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDG68_09025	COG1116	anion transmembrane transporter activity
CDG68_09030	COG0745	RESPONSE REGULATOR receiver
CDG68_09035	COG2223	nitrite transmembrane transporter activity
CDG68_09040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDG68_09040	COG2146	nitrite reductase [NAD(P)H] activity
CDG68_09050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDG68_09055	COG0243	molybdopterin cofactor binding
CDG68_09065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CDG68_09080	COG0521	Mo-molybdopterin cofactor biosynthetic process
CDG68_09080	COG0315	cyclic pyranopterin monophosphate synthase activity
CDG68_09085	COG0303	'Molybdopterin
CDG68_09090	COG0725	ABC transporter, periplasmic molybdate-binding protein
CDG68_09095	COG4149	molybdate abc transporter
CDG68_09110	COG3712	iron ion homeostasis
CDG68_09135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDG68_09145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDG68_09155	COG0582	viral genome integration into host DNA
CDG68_09180	COG0006	proline dipeptidase activity
CDG68_09190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDG68_09195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDG68_09205	COG0625	glutathione transferase activity
CDG68_09245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CDG68_09250	COG1388	LysM domain
CDG68_09250	COG0741	lytic transglycosylase activity
CDG68_09255	COG4166	transmembrane transport
CDG68_09260	COG4174	ABC transporter (Permease)
CDG68_09265	COG4239	(ABC) transporter, permease
CDG68_09270	COG4172	Belongs to the ABC transporter superfamily
CDG68_09280	COG2223	nitrite transmembrane transporter activity
CDG68_09285	COG3708	Transcriptional regulator
CDG68_09285	COG2207	Transcriptional regulator
CDG68_09295	COG0583	DNA-binding transcription factor activity
CDG68_09320	COG0024	Methionine aminopeptidase
CDG68_09325	COG0052	Belongs to the universal ribosomal protein uS2 family
CDG68_09380	COG2951	lytic endotransglycosylase activity
CDG68_09385	COG0772	Belongs to the SEDS family
CDG68_09400	COG0842	Transport permease protein
CDG68_09405	COG1131	(ABC) transporter
CDG68_09435	COG1301	dicarboxylic acid transport
CDG68_09440	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CDG68_09450	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CDG68_09485	COG2318	DinB family
CDG68_09490	COG2070	2-Nitropropane dioxygenase
CDG68_09540	COG0450	alkyl hydroperoxide reductase
CDG68_09565	COG1643	Atp-dependent helicase
CDG68_09600	COG2831	hemolysin activation secretion protein
CDG68_09610	COG2072	flavoprotein involved in K transport
CDG68_09615	COG4221	oxidoreductase activity
CDG68_09620	COG1280	lysine exporter protein (LysE YggA)
CDG68_09630	COG4591	ABC-type transport system involved in lipoprotein release permease component
CDG68_09635	COG1136	(ABC) transporter
CDG68_09640	COG0658	competence protein
CDG68_09640	COG2333	competence protein COMEC
CDG68_09665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CDG68_09670	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CDG68_09675	COG0628	permease
CDG68_09720	COG3634	alkyl hydroperoxide reductase activity
CDG68_09735	COG0583	DNA-binding transcription factor activity
CDG68_09740	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDG68_09750	COG0640	Transcriptional regulator
CDG68_09755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CDG68_09760	COG0798	PFAM Bile acid sodium symporter
CDG68_09780	COG1720	tRNA m6t6A37 methyltransferase activity
CDG68_09965	COG2011	ABC-type metal ion transport system permease component
CDG68_09970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CDG68_09975	COG1464	Belongs to the NlpA lipoprotein family
CDG68_10005	COG0138	bifunctional purine biosynthesis protein purh
CDG68_10010	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CDG68_10045	COG2814	Major facilitator Superfamily
CDG68_10055	COG2308	Evidence 4 Homologs of previously reported genes of
CDG68_10065	COG1305	Transglutaminase-like
CDG68_10075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CDG68_10090	COG0305	Participates in initiation and elongation during chromosome replication
CDG68_10100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CDG68_10105	COG0360	Binds together with S18 to 16S ribosomal RNA
CDG68_10125	COG0109	protoheme IX farnesyltransferase activity
CDG68_10130	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CDG68_10135	COG1845	cytochrome c oxidase, subunit III
CDG68_10140	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CDG68_10145	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CDG68_10170	COG4682	membrane
CDG68_10175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CDG68_10190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CDG68_10195	COG2890	protein-(glutamine-N5) methyltransferase activity
CDG68_10200	COG3781	membrane
CDG68_10205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDG68_10210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDG68_10230	COG1960	acyl-CoA dehydrogenase activity
CDG68_10235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDG68_10240	COG1741	Belongs to the pirin family
CDG68_10245	COG4771	TonB-dependent receptor
CDG68_10255	COG0204	Acyl-transferase
CDG68_10270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CDG68_10280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CDG68_10320	COG0477	Major facilitator Superfamily
CDG68_10325	COG0729	surface antigen
CDG68_10340	COG0318	PFAM AMP-dependent synthetase and ligase
CDG68_10360	COG4783	chaperone-mediated protein folding
CDG68_10370	COG1610	YqeY-like protein
CDG68_10375	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CDG68_10400	COG0436	Aminotransferase
CDG68_10405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDG68_10410	COG0386	Belongs to the glutathione peroxidase family
CDG68_10425	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CDG68_10445	COG0668	transmembrane transport
CDG68_10470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CDG68_10470	COG0519	Catalyzes the synthesis of GMP from XMP
CDG68_10475	COG1309	transcriptional regulator
CDG68_10495	COG0583	DNA-binding transcription factor activity
CDG68_10505	COG3284	Transcriptional regulator
CDG68_10515	COG4221	oxidoreductase activity
CDG68_10520	COG1454	alcohol dehydrogenase
CDG68_10525	COG0183	Belongs to the thiolase family
CDG68_10555	COG0824	Thioesterase
CDG68_10565	COG1454	alcohol dehydrogenase
CDG68_10570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CDG68_10660	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CDG68_10680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDG68_10690	COG0133	tryptophan synthase activity
CDG68_10705	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CDG68_10705	COG0517	IMP dehydrogenase activity
CDG68_10740	COG0612	Peptidase, M16
CDG68_10745	COG0552	protein localization to endoplasmic reticulum
CDG68_10760	COG2707	UPF0756 membrane protein
CDG68_10785	COG0802	atpase or kinase
CDG68_10790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CDG68_10800	COG1923	regulation of RNA biosynthetic process
CDG68_10805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDG68_10815	COG3178	'Phosphotransferase
CDG68_10820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CDG68_10830	COG1192	Involved in chromosome partitioning
CDG68_10835	COG1475	DNA binding
CDG68_10840	COG0811	peptide transport
CDG68_10850	COG1132	(ABC) transporter
CDG68_10855	COG1663	tetraacyldisaccharide 4'-kinase activity
CDG68_10875	COG0084	hydrolase, TatD family'
CDG68_10910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CDG68_10920	COG0590	tRNA wobble adenosine to inosine editing
CDG68_10965	COG0284	orotidine-5'-phosphate decarboxylase activity
CDG68_10975	COG2431	L-lysine efflux transmembrane transporter activity
CDG68_10990	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CDG68_10995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CDG68_11000	COG0569	domain protein
CDG68_11015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CDG68_11020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CDG68_11050	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CDG68_11060	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CDG68_11065	COG0542	response to heat
CDG68_11140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CDG68_11155	COG0308	aminopeptidase N
CDG68_11160	COG0582	viral genome integration into host DNA
CDG68_11330	COG4383	Mu-like prophage protein gp29
CDG68_11560	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CDG68_11560	COG0506	proline dehydrogenase activity
CDG68_11560	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CDG68_11575	COG1027	Aspartate ammonia-lyase
CDG68_11585	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CDG68_11610	COG0477	Major facilitator Superfamily
CDG68_11625	COG1902	pentaerythritol trinitrate reductase activity
CDG68_11625	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDG68_11650	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CDG68_11660	COG4115	mRNA cleavage
CDG68_11665	COG2161	toxin-antitoxin pair type II binding
CDG68_11670	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CDG68_11680	COG0772	Belongs to the SEDS family
CDG68_11685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDG68_11705	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CDG68_11710	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDG68_11725	COG3123	guanosine phosphorylase activity
CDG68_11730	COG0583	DNA-binding transcription factor activity
CDG68_11735	COG0667	Aldo Keto reductase
CDG68_11765	COG1309	transcriptional regulator
CDG68_11775	COG2937	Belongs to the GPAT DAPAT family
CDG68_11780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CDG68_11790	COG0424	maF-like protein
CDG68_11820	COG0583	DNA-binding transcription factor activity
CDG68_11825	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_11835	COG3196	Protein conserved in bacteria
CDG68_11875	COG0702	epimerase
CDG68_11880	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CDG68_11905	COG4589	Belongs to the CDS family
CDG68_11920	COG2453	phosphatase
CDG68_11920	COG0671	phosphoesterase, PA-phosphatase related
CDG68_11925	COG2267	carboxylic ester hydrolase activity
CDG68_11930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CDG68_11970	COG2223	nitrite transmembrane transporter activity
CDG68_11995	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CDG68_12015	COG3122	Protein conserved in bacteria
CDG68_12020	COG3619	membrane
CDG68_12035	COG0640	Transcriptional regulator
CDG68_12070	COG3300	MHYT domain
CDG68_12070	COG5001	Diguanylate cyclase
CDG68_12075	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CDG68_12090	COG2030	dehydratase
CDG68_12105	COG1960	acyl-CoA dehydrogenase activity
CDG68_12150	COG1546	Belongs to the CinA family
CDG68_12150	COG1058	Belongs to the CinA family
CDG68_12165	COG0589	response to stress
CDG68_12190	COG1944	ATP diphosphatase activity
CDG68_12210	COG0789	Transcriptional regulator
CDG68_12225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDG68_12230	COG0730	response to heat
CDG68_12240	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CDG68_12245	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CDG68_12255	COG2205	protein histidine kinase activity
CDG68_12270	COG0583	DNA-binding transcription factor activity
CDG68_12280	COG1346	cytolysis
CDG68_12285	COG2814	Major facilitator Superfamily
CDG68_12515	COG1484	DNA-dependent DNA replication
CDG68_12565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CDG68_12605	COG5377	YqaJ viral recombinase family
CDG68_12615	COG0210	DNA helicase
CDG68_12650	COG0596	Alpha beta hydrolase
CDG68_12660	COG4771	TonB-dependent receptor
CDG68_12670	COG1448	Aminotransferase
CDG68_12675	COG0488	(ABC) transporter
CDG68_12685	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CDG68_12690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CDG68_12705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDG68_12710	COG0697	spore germination
CDG68_12775	COG1294	oxidase, subunit
CDG68_12780	COG1271	oxidase subunit
CDG68_12815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CDG68_12860	COG3501	Rhs element vgr protein
CDG68_12870	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDG68_12875	COG2207	Transcriptional regulator
CDG68_12880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDG68_12885	COG0776	regulation of translation
CDG68_12900	COG1959	2 iron, 2 sulfur cluster binding
CDG68_12910	COG0822	iron-sulfur transferase activity
CDG68_12915	COG0316	Belongs to the HesB IscA family
CDG68_12945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CDG68_12960	COG2850	peptidyl-arginine hydroxylation
CDG68_12970	COG0069	glutamate synthase activity
CDG68_12985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDG68_12995	COG0372	Belongs to the citrate synthase family
CDG68_13030	COG1960	acyl-CoA dehydrogenase activity
CDG68_13035	COG0583	DNA-binding transcription factor activity
CDG68_13045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDG68_13050	COG0583	DNA-binding transcription factor activity
CDG68_13075	COG0511	ligase activity, forming carbon-carbon bonds
CDG68_13080	COG0439	Biotin carboxylase
CDG68_13090	COG2199	diguanylate cyclase activity
CDG68_13110	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CDG68_13120	COG1477	protein flavinylation
CDG68_13130	COG0730	response to heat
CDG68_13135	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CDG68_13165	COG1011	Hydrolase
CDG68_13170	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CDG68_13175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CDG68_13180	COG4221	oxidoreductase activity
CDG68_13185	COG0318	PFAM AMP-dependent synthetase and ligase
CDG68_13190	COG2137	regulation of response to DNA damage stimulus
CDG68_13205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDG68_13215	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDG68_13225	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CDG68_13240	COG0575	Belongs to the CDS family
CDG68_13245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CDG68_13265	COG3852	Histidine kinase
CDG68_13305	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDG68_13310	COG1304	FMN binding
CDG68_13315	COG1132	(ABC) transporter
CDG68_13320	COG1846	Transcriptional regulator
CDG68_13325	COG2814	Major facilitator Superfamily
CDG68_13330	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CDG68_13360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CDG68_13370	COG1585	Membrane protein implicated in regulation of membrane protease activity
CDG68_13385	COG1294	oxidase, subunit
CDG68_13390	COG4890	Cyd operon protein YbgT
CDG68_13395	COG3790	cyd operon protein YbgE
CDG68_13450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CDG68_13465	COG0583	DNA-binding transcription factor activity
CDG68_13470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CDG68_13480	COG3135	benzoate transporter
CDG68_13485	COG0024	Methionine aminopeptidase
CDG68_13490	COG1114	Component of the transport system for branched-chain amino acids
CDG68_13510	COG1253	flavin adenine dinucleotide binding
CDG68_13530	COG3220	belongs to the UPF0276 family
CDG68_13540	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CDG68_13550	COG0583	DNA-binding transcription factor activity
CDG68_13555	COG0786	glutamate:sodium symporter activity
CDG68_13565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDG68_13570	COG1113	amino acid transport
CDG68_13595	COG2807	transmembrane transport
CDG68_13600	COG0590	tRNA wobble adenosine to inosine editing
CDG68_13610	COG0583	DNA-binding transcription factor activity
CDG68_13660	COG1464	Belongs to the NlpA lipoprotein family
CDG68_13665	COG1464	Belongs to the NlpA lipoprotein family
CDG68_13670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CDG68_13675	COG2011	ABC-type metal ion transport system permease component
CDG68_13685	COG0012	GTP binding
CDG68_13700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDG68_13715	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CDG68_13735	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CDG68_13760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDG68_13780	COG1280	lysine exporter protein (LysE YggA)
CDG68_13810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CDG68_13810	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CDG68_13815	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CDG68_13865	COG0778	Nitroreductase
CDG68_13875	COG0513	Belongs to the DEAD box helicase family
CDG68_13880	COG1278	Cold shock
CDG68_13895	COG2363	Small membrane protein
CDG68_13915	COG0625	glutathione transferase activity
CDG68_13920	COG5295	Hep Hag repeat protein
CDG68_13930	COG3851	Histidine kinase
CDG68_13945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CDG68_13955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDG68_13985	COG0540	Belongs to the ATCase OTCase family
CDG68_14020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CDG68_14025	COG0542	response to heat
CDG68_14030	COG1045	serine acetyltransferase
CDG68_14040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDG68_14045	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CDG68_14055	COG1765	OsmC-like protein
CDG68_14065	COG0667	Aldo Keto reductase
CDG68_14080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CDG68_14095	COG1522	sequence-specific DNA binding
CDG68_14115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CDG68_14145	COG0527	aspartate kinase activity
CDG68_14155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CDG68_14165	COG3038	cytochrome b561
CDG68_14175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CDG68_14180	COG2252	PERMEase
CDG68_14200	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CDG68_14205	COG0583	DNA-binding transcription factor activity
CDG68_14250	COG0714	Associated with various cellular activities
CDG68_14260	COG2879	small protein
CDG68_14265	COG1966	Carbon starvation protein
CDG68_14270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CDG68_14275	COG1509	lysine 2,3-aminomutase activity
CDG68_14305	COG2211	Major facilitator Superfamily
CDG68_14310	COG1067	ATP-dependent peptidase activity
CDG68_14315	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CDG68_14320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CDG68_14335	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CDG68_14350	COG1686	Belongs to the peptidase S11 family
CDG68_14355	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CDG68_14360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CDG68_14370	COG0573	inorganic phosphate transmembrane transporter activity
CDG68_14410	COG1137	ATPase activity
CDG68_14415	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CDG68_14425	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CDG68_14430	COG0517	IMP dehydrogenase activity
CDG68_14430	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CDG68_14480	COG0427	acetyl-CoA hydrolase
CDG68_14485	COG0183	Belongs to the thiolase family
CDG68_14490	COG1960	acyl-CoA dehydrogenase activity
CDG68_14505	COG0583	DNA-binding transcription factor activity
CDG68_14550	COG1671	Belongs to the UPF0178 family
CDG68_14560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CDG68_14585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDG68_14600	COG1301	dicarboxylic acid transport
CDG68_14610	COG0047	phosphoribosylformylglycinamidine synthase activity
CDG68_14610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CDG68_14635	COG0632	four-way junction helicase activity
CDG68_14650	COG0824	Thioesterase
CDG68_14675	COG0823	Involved in the tonB-independent uptake of proteins
CDG68_14695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDG68_14745	COG0512	Glutamine amidotransferase of anthranilate synthase
CDG68_14750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDG68_14795	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_14800	COG1960	acyl-CoA dehydrogenase activity
CDG68_14820	COG3739	integral membrane protein
CDG68_14835	COG1741	Belongs to the pirin family
CDG68_14905	COG0352	thiamine-phosphate diphosphorylase activity
CDG68_14915	COG3022	response to hydroperoxide
CDG68_14925	COG4650	regulator
CDG68_14940	COG1234	tRNA 3'-trailer cleavage
CDG68_14950	COG1690	Belongs to the RtcB family
CDG68_14975	COG0430	RNA-3'-phosphate cyclase activity
CDG68_14990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CDG68_15000	COG0693	protein deglycase activity
CDG68_15005	COG1960	acyl-CoA dehydrogenase activity
CDG68_15010	COG0616	signal peptide processing
CDG68_15035	COG0482	sulfurtransferase activity
CDG68_15040	COG2915	High frequency lysogenization protein hflD homolog
CDG68_15060	COG1733	regulation of RNA biosynthetic process
CDG68_15065	COG0702	epimerase
CDG68_15095	COG0556	nucleotide-excision repair
CDG68_15105	COG3706	GGDEF domain
CDG68_15105	COG0745	RESPONSE REGULATOR receiver
CDG68_15170	COG3299	homolog of phage Mu protein gp47
CDG68_15225	COG4397	Mu-like prophage major head subunit gpT
CDG68_15245	COG2369	cell adhesion
CDG68_15250	COG4383	Mu-like prophage protein gp29
CDG68_15270	COG4373	Mu-like prophage FluMu protein gp28
CDG68_15305	COG1396	sequence-specific DNA binding
CDG68_15345	COG0776	regulation of translation
CDG68_15375	COG4382	Mu-like prophage protein Gp16
CDG68_15395	COG3501	Rhs element vgr protein
CDG68_15430	COG2871	sodium ion transport
CDG68_15445	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CDG68_15455	COG0076	glutamate decarboxylase activity
CDG68_15460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CDG68_15470	COG0671	phosphoesterase, PA-phosphatase related
CDG68_15475	COG4772	TonB-dependent receptor
CDG68_15500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDG68_15520	COG1022	Amp-dependent synthetase and ligase
CDG68_15525	COG2197	response regulator
CDG68_15560	COG4993	Dehydrogenase
CDG68_15590	COG0612	Peptidase, M16
CDG68_15595	COG0384	phenazine biosynthesis protein PhzF
CDG68_15610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDG68_15625	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CDG68_15640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CDG68_15670	COG3139	Protein of unknown function (DUF1315)
CDG68_15675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CDG68_15680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CDG68_15690	COG0494	nUDIX hydrolase
CDG68_15700	COG0642	Histidine kinase
CDG68_15705	COG0745	RESPONSE REGULATOR receiver
CDG68_15745	COG1203	CRISPR-associated helicase, Cas3
CDG68_15750	COG1518	maintenance of DNA repeat elements
CDG68_15760	COG3327	negative regulation of DNA-templated transcription, initiation
CDG68_15765	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CDG68_15770	COG0183	Belongs to the thiolase family
CDG68_15775	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDG68_15780	COG1024	Enoyl-CoA hydratase
CDG68_15785	COG1024	Enoyl-CoA hydratase
CDG68_15790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDG68_15795	COG2151	metal-sulfur cluster biosynthetic enzyme
CDG68_15800	COG3396	Phenylacetate-CoA oxygenase
CDG68_15805	COG3460	Phenylacetate-CoA oxygenase
CDG68_15810	COG3396	Phenylacetate-CoA oxygenase
CDG68_15815	COG2030	dehydratase
CDG68_15815	COG1012	belongs to the aldehyde dehydrogenase family
CDG68_15825	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CDG68_15830	COG0477	Major facilitator Superfamily
CDG68_15845	COG1116	anion transmembrane transporter activity
CDG68_15850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDG68_15860	COG0864	Transcriptional regulator
CDG68_15875	COG0439	Biotin carboxylase
CDG68_15890	COG1063	alcohol dehydrogenase
CDG68_15895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDG68_15900	COG0508	dehydrogenase complex catalyzes the overall conversion of
CDG68_15905	COG0022	dehydrogenase e1 component
CDG68_15910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CDG68_15915	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CDG68_15930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDG68_15935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CDG68_15950	COG1686	Belongs to the peptidase S11 family
CDG68_15955	COG1252	NADH dehydrogenase
CDG68_15960	COG1047	Peptidyl-prolyl cis-trans
CDG68_15965	COG0415	Belongs to the DNA photolyase family
CDG68_15985	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CDG68_16000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CDG68_16005	COG0571	ribonuclease III activity
CDG68_16035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDG68_16065	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CDG68_16070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CDG68_16075	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CDG68_16085	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CDG68_16090	COG4208	sulfate ABC transporter
CDG68_16095	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CDG68_16100	COG0583	DNA-binding transcription factor activity
CDG68_16120	COG0602	queuosine metabolic process
CDG68_16125	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CDG68_16140	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CDG68_16150	COG0583	DNA-binding transcription factor activity
CDG68_16165	COG1024	Enoyl-CoA hydratase
CDG68_16170	COG0778	Nitroreductase
CDG68_16180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CDG68_16180	COG3323	Protein of unknown function (DUF1653)
CDG68_16210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDG68_16230	COG1280	lysine exporter protein (LysE YggA)
CDG68_16265	COG2234	aminopeptidase activity
CDG68_16270	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CDG68_16275	COG3384	dioxygenase
CDG68_16300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CDG68_16305	COG2878	Part of a membrane complex involved in electron transport
CDG68_16310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CDG68_16340	COG0768	penicillin binding
CDG68_16345	COG0742	ribosomal rna small subunit methyltransferase
CDG68_16360	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_16365	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CDG68_16375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDG68_16390	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CDG68_16395	COG1053	succinate dehydrogenase
CDG68_16400	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CDG68_16405	COG2009	succinate dehydrogenase
CDG68_16415	COG3104	oligopeptide transport
CDG68_16430	COG2072	flavoprotein involved in K transport
CDG68_16435	COG0300	oxidoreductase activity
CDG68_16460	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CDG68_16460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CDG68_16485	COG2304	oxidoreductase activity
CDG68_16495	COG2304	oxidoreductase activity
CDG68_16500	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CDG68_16505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDG68_16510	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CDG68_16530	COG0505	Belongs to the CarA family
CDG68_16535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CDG68_16550	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CDG68_16570	COG1024	Enoyl-CoA hydratase
CDG68_16600	COG2321	neutral zinc metallopeptidase
CDG68_16605	COG2354	Protein conserved in bacteria
CDG68_16630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CDG68_16635	COG1773	rubredoxin
CDG68_16640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDG68_16645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CDG68_16650	COG0583	DNA-binding transcription factor activity
CDG68_16685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CDG68_16695	COG0321	lipoyl(octanoyl) transferase activity
CDG68_16710	COG0531	amino acid
CDG68_16720	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_16740	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CDG68_16745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CDG68_16745	COG1648	precorrin-2 dehydrogenase activity
CDG68_16750	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CDG68_16760	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CDG68_16765	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CDG68_16780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CDG68_16795	COG0671	phosphoesterase, PA-phosphatase related
CDG68_16800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDG68_16810	COG1538	Outer membrane efflux protein
CDG68_16815	COG0393	Putative heavy-metal-binding
CDG68_16840	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_16850	COG0525	valine-tRNA ligase activity
CDG68_16910	COG3590	peptidase
CDG68_16940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CDG68_16950	COG0582	viral genome integration into host DNA
CDG68_16990	COG3210	domain, Protein
CDG68_16995	COG2831	hemolysin activation secretion protein
CDG68_17150	COG0625	glutathione transferase activity
CDG68_17200	COG4372	Transposase
CDG68_17210	COG0582	viral genome integration into host DNA
CDG68_17230	COG0242	peptide deformylase activity
CDG68_17240	COG0477	Major facilitator Superfamily
CDG68_17245	COG3706	GGDEF domain
CDG68_17245	COG0745	RESPONSE REGULATOR receiver
CDG68_17290	COG1585	Membrane protein implicated in regulation of membrane protease activity
CDG68_17295	COG2268	Band 7 protein
CDG68_17310	COG0204	Acyl-transferase
CDG68_17320	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CDG68_17320	COG1674	ftsk spoiiie
CDG68_17325	COG0492	ferredoxin-NADP+ reductase activity
CDG68_17330	COG0500	methyltransferase
CDG68_17335	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CDG68_17345	COG0456	acetyltransferase
CDG68_17370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CDG68_17405	COG1113	amino acid transport
CDG68_17410	COG0251	oxidation-reduction process
CDG68_17440	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CDG68_17440	COG0351	phosphomethylpyrimidine kinase
CDG68_17440	COG0352	thiamine-phosphate diphosphorylase activity
CDG68_17460	COG2076	Multidrug Resistance protein
CDG68_17465	COG2076	Multidrug Resistance protein
CDG68_17480	COG2132	Multicopper oxidase
CDG68_17490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CDG68_17505	COG4269	membrane
CDG68_17510	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CDG68_17525	COG1968	undecaprenyl-diphosphatase activity
CDG68_17530	COG1214	PFAM Peptidase M22, glycoprotease
CDG68_17535	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CDG68_17540	COG0494	nUDIX hydrolase
CDG68_17580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CDG68_17590	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CDG68_17595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CDG68_17620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDG68_17625	COG0765	amino acid transport
CDG68_17630	COG0765	amino acid transport
CDG68_17635	COG1126	abc transporter atp-binding protein
CDG68_17655	COG4716	Myosin-crossreactive antigen
CDG68_17690	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CDG68_17695	COG3210	domain, Protein
CDG68_17705	COG2081	HI0933 family
CDG68_17710	COG0668	transmembrane transport
CDG68_17730	COG0583	DNA-binding transcription factor activity
CDG68_17760	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDG68_17765	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CDG68_17770	COG0713	ATP synthesis coupled electron transport
CDG68_17780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDG68_17785	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CDG68_17795	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CDG68_17815	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDG68_17825	COG2205	protein histidine kinase activity
CDG68_17830	COG0745	RESPONSE REGULATOR receiver
CDG68_17845	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CDG68_17855	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CDG68_17860	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CDG68_17880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDG68_17885	COG0601	transmembrane transport
CDG68_17895	COG4166	transmembrane transport
CDG68_17900	COG4166	transmembrane transport
CDG68_17930	COG2824	Alkylphosphonate utilization operon protein PhnA
CDG68_17960	COG1408	metallophosphoesterase
CDG68_17965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CDG68_17975	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CDG68_17985	COG1346	cytolysis
CDG68_18010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CDG68_18015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CDG68_18025	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CDG68_18030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CDG68_18035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CDG68_18045	COG0625	glutathione transferase activity
CDG68_18050	COG2969	positive regulation of protein catabolic process
CDG68_18125	COG0354	folic acid binding
CDG68_18160	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CDG68_18185	COG0285	dihydrofolate synthase activity
CDG68_18190	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CDG68_18235	COG0183	Belongs to the thiolase family
CDG68_18245	COG2207	Transcriptional regulator
CDG68_18250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDG68_18265	COG0494	nUDIX hydrolase
CDG68_18280	COG3422	double-strand break repair
CDG68_18300	COG4106	trans-aconitate 2-methyltransferase activity
CDG68_18315	COG2267	carboxylic ester hydrolase activity
CDG68_18320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CDG68_18325	COG2193	ferroxidase activity
CDG68_18360	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CDG68_18370	COG1196	nuclear chromosome segregation
CDG68_18390	COG0730	response to heat
CDG68_18410	COG3545	Serine hydrolase
CDG68_18415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CDG68_18465	COG3501	Rhs element vgr protein
CDG68_18480	COG2153	protein acetylation
CDG68_18490	COG1272	protein, Hemolysin III
CDG68_18495	COG0477	Major facilitator Superfamily
CDG68_18500	COG0564	pseudouridine synthase activity
CDG68_18510	COG1024	Enoyl-CoA hydratase
CDG68_18515	COG1960	acyl-CoA dehydrogenase activity
CDG68_18520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CDG68_18525	COG1028	Short-chain dehydrogenase reductase Sdr
CDG68_18535	COG1309	transcriptional regulator
CDG68_18555	COG1960	acyl-CoA dehydrogenase activity
CDG68_18560	COG1960	acyl-CoA dehydrogenase activity
CDG68_18565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CDG68_18615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CDG68_18625	COG1764	response to oxidative stress
CDG68_18690	COG3384	dioxygenase
CDG68_18705	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDG68_18715	COG0133	tryptophan synthase activity
CDG68_18730	COG4206	TonB-dependent receptor
CDG68_18760	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CDG68_18790	COG2315	Protein conserved in bacteria
CDG68_18795	COG0745	RESPONSE REGULATOR receiver
CDG68_18800	COG2205	protein histidine kinase activity
CDG68_18810	COG3028	Belongs to the UPF0307 family
CDG68_18815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CDG68_18820	COG1660	Displays ATPase and GTPase activities
CDG68_18825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CDG68_18835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CDG68_18840	COG0617	tRNA 3'-terminal CCA addition
CDG68_18845	COG1596	polysaccharide export
CDG68_18845	COG1555	photosystem II stabilization
CDG68_18850	COG3956	TIGRFAM MazG family protein
CDG68_18865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDG68_18885	COG5002	protein histidine kinase activity
CDG68_18885	COG0784	Response regulator, receiver
CDG68_18885	COG2205	protein histidine kinase activity
CDG68_18890	COG1024	Enoyl-CoA hydratase
CDG68_18895	COG2084	Dehydrogenase
CDG68_18900	COG3622	Belongs to the hyi family
CDG68_18910	COG0004	ammonium transporteR
CDG68_18925	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CDG68_18940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CDG68_18945	COG1426	Protein conserved in bacteria
CDG68_19010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CDG68_19015	COG0440	acetolactate synthase activity
CDG68_19020	COG0028	Belongs to the TPP enzyme family
CDG68_19045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDG68_19050	COG1136	(ABC) transporter
CDG68_19050	COG0577	efflux transmembrane transporter activity
CDG68_19055	COG1538	Outer membrane efflux protein
CDG68_19105	COG3501	Rhs element vgr protein
CDG68_19120	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CDG68_19125	COG1162	GTPase activity
CDG68_19170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CDG68_19175	COG2003	Belongs to the UPF0758 family
CDG68_19180	COG3781	membrane
CDG68_19210	COG1946	Acyl-CoA thioesterase
CDG68_19230	COG1295	ribonuclease BN
CDG68_19260	COG0179	Fumarylacetoacetate (FAA) hydrolase
CDG68_19285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDG68_19290	COG1126	abc transporter atp-binding protein
CDG68_19295	COG0765	amino acid transport
CDG68_19300	COG0765	amino acid transport
CDG68_19330	COG0557	exoribonuclease II activity
CDG68_19350	COG0339	signal peptide processing
CDG68_19355	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CDG68_19395	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CDG68_19400	COG1960	acyl-CoA dehydrogenase activity
CDG68_19420	COG2072	flavoprotein involved in K transport
CDG68_19425	COG0203	ribosomal protein L17
CDG68_19430	COG0202	RNA polymerase activity
CDG68_19440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CDG68_19450	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CDG68_19470	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CDG68_19480	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CDG68_19485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CDG68_19490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CDG68_19495	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CDG68_19505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CDG68_19525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CDG68_19535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CDG68_19550	COG0088	Forms part of the polypeptide exit tunnel
CDG68_19560	COG0051	transcription antitermination factor activity, RNA binding
CDG68_19570	COG0626	cystathionine gamma-synthase activity
CDG68_19575	COG0433	COG0433 Predicted ATPase
CDG68_19580	COG1017	nitric oxide dioxygenase activity
CDG68_19580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDG68_19585	COG1959	2 iron, 2 sulfur cluster binding
CDG68_19600	COG1301	dicarboxylic acid transport
CDG68_19605	COG1946	Acyl-CoA thioesterase
CDG68_19610	COG2937	Belongs to the GPAT DAPAT family
CDG68_19645	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CDG68_19650	COG1040	competence protein
CDG68_19655	COG0494	nUDIX hydrolase
CDG68_19665	COG0598	Magnesium transport protein CorA
CDG68_19675	COG2854	intermembrane phospholipid transfer
CDG68_19680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CDG68_19685	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CDG68_19690	COG1127	ABC transporter
CDG68_19695	COG0513	Belongs to the DEAD box helicase family
CDG68_19710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CDG68_19715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CDG68_19720	COG0408	coproporphyrinogen oxidase activity
CDG68_19740	COG1960	acyl-CoA dehydrogenase activity
CDG68_19750	COG2814	Major facilitator Superfamily
CDG68_19755	COG1733	regulation of RNA biosynthetic process
CDG68_19760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CDG68_19770	COG0534	Mate efflux family protein
CDG68_19780	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CDG68_19785	COG0254	rRNA binding
CDG68_19790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CDG68_19805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDG68_19815	COG0493	'glutamate synthase
CDG68_19815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDG68_19825	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CDG68_19840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDG68_19855	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CDG68_19865	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CDG68_19865	COG0644	oxidoreductase
CDG68_19880	COG3501	Rhs element vgr protein
CDG68_19885	COG0425	Belongs to the sulfur carrier protein TusA family
CDG68_19890	COG4535	Mg2 and Co2 transporter CorC
CDG68_19895	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CDG68_19920	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CDG68_19945	COG0628	permease
CDG68_19950	COG2032	superoxide dismutase activity
CDG68_19965	COG1289	transmembrane transporter activity
CDG68_19970	COG2814	Major facilitator Superfamily
CDG68_20005	COG0277	FAD linked oxidase domain protein
CDG68_20010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CDG68_20015	COG5006	permease, DMT superfamily
CDG68_20020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CDG68_20060	COG5380	lipid catabolic process
CDG68_20065	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CDG68_20075	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CDG68_20080	COG0335	large ribosomal subunit rRNA binding
CDG68_20090	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CDG68_20095	COG0228	four-way junction DNA binding
CDG68_20185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CDG68_20190	COG0194	GDP metabolic process
CDG68_20195	COG1758	RNA polymerase activity
CDG68_20200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDG68_20220	COG3307	-O-antigen
CDG68_20230	COG3307	-O-antigen
CDG68_20245	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CDG68_20250	COG1704	LemA family
CDG68_20260	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CDG68_20270	COG0195	Participates in both transcription termination and antitermination
CDG68_20275	COG0779	Required for maturation of 30S ribosomal subunits
CDG68_20325	COG0237	dephospho-CoA kinase activity
CDG68_20335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDG68_20340	COG3123	guanosine phosphorylase activity
CDG68_20350	COG0497	DNA recombination
CDG68_20375	COG1678	Uncharacterized ACR, COG1678
CDG68_20380	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CDG68_20400	COG1289	transmembrane transporter activity
CDG68_20410	COG2249	NAD(P)H dehydrogenase (quinone) activity
CDG68_20420	COG1132	(ABC) transporter
CDG68_20440	COG4974	Belongs to the 'phage' integrase family
CDG68_20445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CDG68_20455	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CDG68_20460	COG1686	Belongs to the peptidase S11 family
CDG68_20465	COG2197	response regulator
CDG68_20470	COG5002	protein histidine kinase activity
CDG68_20480	COG0793	Belongs to the peptidase S41A family
CDG68_20485	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CDG68_20490	COG0795	lipopolysaccharide-transporting ATPase activity
CDG68_20495	COG0795	lipopolysaccharide-transporting ATPase activity
CDG68_20525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CDG68_20555	COG1024	Enoyl-CoA hydratase
CDG68_20555	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDG68_20560	COG0183	Belongs to the thiolase family
CDG68_20580	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CDG68_20600	COG0326	Molecular chaperone. Has ATPase activity
CDG68_20620	COG2056	Na+-H+ antiporter family
CDG68_20650	COG0085	RNA polymerase activity
CDG68_20660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CDG68_20665	COG0081	regulation of translation
CDG68_20680	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CDG68_20770	COG0181	hydroxymethylbilane synthase activity
CDG68_20780	COG3275	phosphorelay sensor kinase activity
CDG68_20805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CDG68_20820	COG3158	transport of potassium into the cell
CDG68_20855	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CDG68_20865	COG0450	alkyl hydroperoxide reductase
CDG68_20915	COG0629	single-stranded DNA binding
CDG68_20935	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CDG68_20980	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CDG68_21055	COG2826	transposase and inactivated derivatives, IS30 family
CDG68_21085	COG1324	tolerance protein
CDG68_21090	COG0673	inositol 2-dehydrogenase activity
CDG68_21110	COG2826	transposase and inactivated derivatives, IS30 family
CDG68_21190	COG2814	Major facilitator Superfamily
CDG68_21200	COG0351	phosphomethylpyrimidine kinase
CDG68_21200	COG0352	thiamine-phosphate diphosphorylase activity
CDG68_21200	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CDG68_21240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CDG68_21245	COG0697	spore germination
CDG68_21290	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CDG68_21325	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CDG68_21350	COG0426	domain, Protein
CDG68_21350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDG68_21355	COG2119	membrane
CDG68_21380	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CDG68_21395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CDG68_21405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CDG68_21415	COG0189	ligase activity
CDG68_21440	COG0708	Exodeoxyribonuclease III
CDG68_21445	COG1393	Belongs to the ArsC family
CDG68_21465	COG3706	GGDEF domain
CDG68_21495	COG1247	-acetyltransferase
CDG68_21510	COG3150	esterase
CDG68_21530	COG2918	glutathione biosynthetic process
CDG68_21545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CDG68_21555	COG2733	membrane
CDG68_21575	COG0436	Aminotransferase
CDG68_21580	COG0534	Mate efflux family protein
CDG68_21650	COG3830	Belongs to the UPF0237 family
CDG68_21650	COG0560	Phosphoserine phosphatase
CDG68_21665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CDG68_21675	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CDG68_21680	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CDG68_21690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CDG68_21770	COG0514	ATP-dependent DNA helicase (RecQ)
CDG68_21795	COG2207	Transcriptional regulator
CDG68_21800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CDG68_21815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CDG68_21820	COG2819	hydrolase of the alpha beta superfamily
CDG68_21825	COG2983	Belongs to the UPF0260 family
CDG68_21830	COG5487	UPF0391 membrane protein
CDG68_21835	COG5487	UPF0391 membrane protein
CDG68_21850	COG1194	a g-specific adenine glycosylase
CDG68_21855	COG0739	heme binding
CDG68_21865	COG2818	Glycosylase
CDG68_21870	COG1064	alcohol dehydrogenase
CDG68_21875	COG0156	8-amino-7-oxononanoate synthase activity
CDG68_21885	COG0583	DNA-binding transcription factor activity
CDG68_21890	COG0656	L-ascorbic acid biosynthetic process
CDG68_21895	COG2814	Major facilitator Superfamily
CDG68_21935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDG68_21945	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CDG68_21950	COG2233	PERMEase
CDG68_21960	COG1228	amidohydrolase
CDG68_21970	COG0196	riboflavin kinase activity
CDG68_21975	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CDG68_21980	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CDG68_21985	COG1047	Peptidyl-prolyl cis-trans
CDG68_21995	COG3077	Addiction module antitoxin, RelB DinJ family
CDG68_22000	COG0583	DNA-binding transcription factor activity
CDG68_22010	COG0174	glutamine synthetase
CDG68_22050	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CDG68_22065	COG0733	neurotransmitter:sodium symporter activity
CDG68_22070	COG3738	Protein conserved in bacteria
CDG68_22075	COG1012	belongs to the aldehyde dehydrogenase family
CDG68_22090	COG2814	Major facilitator Superfamily
CDG68_22125	COG0737	Belongs to the 5'-nucleotidase family
CDG68_22135	COG2175	clavaminate synthase activity
CDG68_22140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDG68_22145	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CDG68_22150	COG4521	taurine ABC transporter
CDG68_22170	COG0443	Heat shock 70 kDa protein
CDG68_22175	COG0789	Transcriptional regulator
CDG68_22210	COG2951	lytic endotransglycosylase activity
CDG68_22220	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CDG68_22245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CDG68_22265	COG2388	GCN5-related N-acetyl-transferase
CDG68_22270	COG2388	GCN5-related N-acetyl-transferase
CDG68_22280	COG0861	Integral membrane protein TerC family
CDG68_22295	COG0754	glutathionylspermidine amidase activity
CDG68_22310	COG0402	S-adenosylhomocysteine deaminase activity
CDG68_22325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CDG68_22330	COG1230	cation diffusion facilitator family transporter
CDG68_22360	COG0706	membrane insertase activity
CDG68_22365	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CDG68_22375	COG0230	Belongs to the bacterial ribosomal protein bL34 family